An insecticide composition

Abstract

The present invention relates to an insecticidal composition, which contains active ingredients Compound I and Compound II, wherein Compound II is selected from at least one of spinosad, spinetoram, bromofenac, thiobencarb, sulfoxaflor, emamectin benzoate, cypermethrin, ethoprolin, and bifenthrin. The present invention also relates to the use of the insecticidal composition for preventing or controlling pests of the families Plutella xylostella, Tortricidae, Noctuidae, Delphacidae, Aleyrodidae, Tetranychus, Thripidae, Aphididae, and Cyprinococcidae. Compound I.

Description

[0001] This application is a divisional application of the patent application filed by the applicant on July 2, 2020, with patent number "2020106269426" and patent title "An Insecticidal Composition". Technical Field

[0002] The present invention relates to an insecticidal composition that is particularly effective in controlling agricultural and forestry pests. Background Technology

[0003] One of the most typical problems in agricultural and horticultural pest control is the need to reduce the dosage rate of active ingredients to minimize or avoid adverse environmental or toxicological effects while still providing effective pest control.

[0004] Another challenge in pest control lies in the fact that repeated and singular use of a single insecticidal active ingredient often leads to rapid selection by pests that develop natural or adaptive resistance to that active ingredient. Due to the multigenerational and adaptive nature of pests, resistance develops in a relatively short time. Therefore, there is a need for pest control agents that are effective against both the pest and its larvae and eggs.

[0005] Addressing at least one of the following issues—such as improving biological properties, providing synergistic effects, reducing dosage rates, broadening the spectrum of activity, combining knockout activity with long-lasting effects, and managing resistance to delay resistance development—is a long-term need for controlling agricultural or forestry pests.

[0006] Compound I is known from WO2006013896 and belongs to the quinoline derivatives.

[0007]

[0008] Compound I Summary of the Invention

[0009] The purpose of this invention is to address the aforementioned shortcomings by providing an insecticidal composition containing active ingredients compound I and compound II. The combination of compound I and compound II effectively prevents or controls animal pests, their larvae, and eggs. We have found that applying compound I and compound II in combination or separately, or sequentially, yields a higher control effect against pests compared to the control rates that may be achieved by applying the compounds individually. The combination of compound I and compound II exhibits high efficiency, reduces the dosage rate, and minimizes environmental impact.

[0010] The insecticidal composition of the present invention is achieved by the following technical solution:

[0011] An insecticidal composition comprising active ingredients compound I and compound II,

[0012]

[0013] Compound I

[0014] Compound II is selected from one of the following compounds: spinosad, ethyl spinosad, brofenoxam, thiofenoxam, flonicamid, abamectin, chlorfenapyr, permethrin, and bifenthrin.

[0015] The weight ratio of compound I and compound II is typically in the range of 500:1-1:500, more preferably 200:1-1:200, more preferably 100:1-1:100, more preferably 50:1-1:50, and more preferably 25:1-1:25, thus achieving a synergistic effect; compound II is selected from one of the following compounds: spinosad, ethyl spinosad, brofenoxam, thiophanate-methyl, flonicamid, abamectin, chlorfenapyr, permethrin, and bifenthrin.

[0016] Compound I and Compound II described in this invention have completely different mechanisms of action and modes of action. When combined, they have contact toxicity, stomach poisoning, ovicidal effects, and can reduce oviposition and hatching rates, making pests easier to kill and thus delaying the development of resistance.

[0017] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein the total weight of compound I and compound II accounts for 1%-90% by weight of the insecticidal composition, preferably 5%-80%, more preferably 5%-70%, even more preferably 5%-60%, more preferably 5%-50%, more preferably 10%-50%, and more preferably 10%-40%.

[0018] An insecticidal composition comprising active ingredients compound I and compound II, wherein the total weight of compound I and compound II constitutes, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, or 90% of the total weight of the insecticidal composition.

[0019] An insecticidal composition comprising active ingredients compound I and compound II, the insecticidal composition further comprising surfactants and / or fillers.

[0020] The insecticidal composition of the present invention is available in the following formulations: emulsifiable concentrate, aqueous suspension, oil suspension, seed-treated dry powder, seed-treated suspension, water-dispersible granules, wettable powder, suspension emulsion, water emulsion, microcapsule suspension, dry suspension, ultra-low volume liquid, microparticles, and microemulsion.

[0021] The insecticidal composition of the present invention can be applied undiluted or diluted with water.

[0022] The insecticidal composition of the present invention unexpectedly exhibits extremely high activity in preventing or controlling pests and their larvae and eggs when applied to plants, plant propagation materials, and soil in which plants grow.

[0023] The insecticidal composition of the present invention has excellent control efficacy against pests, their larvae, and eggs at low doses.

[0024] On the other hand, the present invention also provides the use of an insecticidal composition for the prevention or control of pests and their larvae and eggs.

[0025] In particular, the present invention provides an insecticidal composition for the prevention or control of pests belonging to the orders Lepidoptera, Hemiptera, Diptera, Thysanoptera, and Acari.

[0026] This invention provides an insecticidal composition for the prevention or control of pests belonging to the families Diamondback moth, Tocopheridae, Noctuidae, Planthopper, Whitefly, Tetranychidae, Thrips, Aphids, and Chrysalis, as well as their larvae and eggs.

[0027] More specifically, the present invention provides an insecticidal composition for the prevention or control of diamondback moth, beet leafminer, carmine spider mite, whitefly, tobacco thrips, tobacco aphid and their larvae and eggs.

[0028] The insecticidal composition of the present invention is used for treating seeds to prevent seed infestation by pests.

[0029] The insecticidal composition of the present invention can be applied to seeds, plants or fruits of plants or soil in which plants grow or soil suitable for plant growth.

[0030] On the other hand, the present invention also provides a method for preventing or controlling pests and their larvae and eggs, by applying the insecticidal composition of the present invention to a target useful plant, a target pest or its environment, or the propagation material of the target useful plant. The plant propagation material is seedlings, rhizomes, nursery seedlings, cuttings, or seeds.

[0031] A method for preventing or controlling pests and their larvae and eggs, comprising applying the insecticidal composition of the present invention to seeds, target useful plants, or soil in which plants grow or soil suitable for plant growth.

[0032] A method for preventing or controlling pests and their larvae and eggs, comprising applying the insecticidal composition of the present invention to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

[0033] A method for protecting seeds includes contacting the seeds with an insecticidally effective amount of the insecticidal composition of the present invention before sowing and / or after germination.

[0034] The plants mentioned can include: plant stems and leaves, plant flowers, plant fruits, etc.

[0035] The seeds mentioned are selected from soybean, wheat, barley, rye, sorghum, peanut, sunflower, sugarcane, tobacco, rice, rapeseed, bok choy, cabbage, beet, tomato, cowpea, carrot, cotton and corn seeds.

[0036] A method for preventing or controlling pests includes applying compound I and compound II separately, sequentially, or simultaneously.

[0037] The insecticidal composition of the present invention can be applied in any desired manner, such as seed coating, soil irrigation and / or direct furrow application and / or foliar spraying, and application before, after, or before and after germination.

[0038] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, which addresses at least one problem such as improving biological properties, providing synergistic properties, reducing dosage rate, broadening the activity spectrum, combining knockout activity and long-lasting effect, and managing resistance to delay resistance. Detailed Implementation

[0039] To facilitate understanding of the present invention, the following embodiments are provided. Those skilled in the art should understand that these embodiments are merely illustrative and should not be construed as limiting the scope of the invention.

[0040] This invention reveals that combining compound I and compound II can effectively prevent or control pests, their larvae, and eggs. Surprisingly, the insecticidal composition of this invention exhibits a significantly higher activity in controlling pests than the sum of the individual active compounds. This unexpected effect is a true synergistic effect, not merely an additive sum of activities.

[0041] As used herein, the term "synergistic effect" means that the insecticidal effect of the combination or composition of active compounds of the present invention is greater than the sum of the effects of the individual active compounds, or that its effect is superadditive.

[0042] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from one of the following compounds: spinosad, ethyl spinosad, brofenoxam, thiofenoxam, flonicamid, abamectin, chlorfenapyr, permethrin, and bifenthrin.

[0043] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from spinosad or ethyl spinosad.

[0044] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from bromonitrile diphenyl ether or thiophene.

[0045] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from flonicamid.

[0046] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from abamectin.

[0047] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from chlorfenapyr.

[0048] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein compound II is selected from ethoxyphen ...

[0049] The insecticidal composition of the present invention can be combined in the following ways:

[0050] (1) Compound I + bactericide;

[0051] (2) Compound I+Ethyl spinosad;

[0052] (3) Compound I + bromoxynil diamide;

[0053] (4) Compound I + Thionamide;

[0054] (5) Compound I + acaricide;

[0055] (6) Compound I + flonicamid;

[0056] (7) Compound I + abamectin;

[0057] (8) Compound I + Ethephon;

[0058] (9) Compound I + bifenthrin;

[0059] The weight ratio of compound I and compound II is typically in the range of 500:1-1:500, more preferably 200:1-1:200, more preferably 100:1-1:100, more preferably 50:1-1:50, and more preferably 25:1-1:25, thus achieving a synergistic effect.

[0060] The weight ratio of compound I and compound II described in this invention can also be, for example, 500:1, 250:1, 200:1, 150:1, 100:1, 50:1, 45:1, 40:1, 35:1, 30:1, 25:1, 20:1, 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1. 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:100, 1:150, 1:200, 1:250, 1:500.

[0061] Particularly preferred are insecticidal compositions comprising compound I and spinosad or ethyl spinosad; wherein, compound I and spinosad or ethyl spinosad are present in a synergistically effective amount; preferably, the weight ratio of compound I to spinosad or ethyl spinosad is 50:1-1:50, preferably 25:1-1:25, preferably 20:1-1:20, preferably 5:1-1:20, and more preferably 1:1-1:20.

[0062] It is also preferred to include an insecticidal composition comprising compound I and brofenoxam or thiofenoxam; wherein, compound I and brofenoxam or thiofenoxam are present in a synergistically effective amount; preferably, the weight ratio of compound I to brofenoxam or thiofenoxam is 50:1-1:50, preferably 25:1-1:25, preferably 20:1-1:20, preferably 10:1-1:10, and more preferably 5:1-1:5.

[0063] Furthermore, an insecticidal composition comprising compound I and chlorfenapyr is particularly preferred; wherein, compound I and chlorfenapyr are present in a synergistically effective amount; preferably, the weight ratio of compound I to chlorfenapyr is 50:1-1:50, preferably 25:1-1:50, preferably 20:1-1:50, preferably 10:1-1:50, and even more preferably 5:1-1:25.

[0064] Furthermore, an insecticidal composition comprising compound I and flonicamid is particularly preferred; wherein, compound I and flonicamid are present in a synergistically effective amount; preferably, the weight ratio of compound I to flonicamid is 50:1-1:50, preferably 25:1-1:25, preferably 20:1-1:20, preferably 10:1-1:10, and more preferably 5:1-1:5.

[0065] Furthermore, an insecticidal composition comprising compound I and emamectin benzoate is particularly preferred; wherein, compound I and emamectin benzoate are present in a synergistically effective amount; preferably, the weight ratio of compound I to emamectin benzoate is 500:1-1:200, preferably 250:1-1:100, preferably 250:1-1:50, and preferably 200:1-1:50.

[0066] Furthermore, an insecticidal composition comprising compound I and permethrin or bifenthrin is particularly preferred; wherein, compound I and permethrin or bifenthrin are present in a synergistically effective amount; preferably, the weight ratio of compound I to permethrin or bifenthrin is 50:1-1:50, preferably 25:1-1:25, preferably 20:1-1:20, preferably 10:1-1:10, and more preferably 5:1-1:5.

[0067] The preparation of compound II and its effects on pests are known. It can be found in The Pesticide Manual, 16th edition, and other publications.

[0068] The insecticidal composition of this invention exhibits good plant compatibility and favorable homeothermic animal toxicity, making it suitable for controlling pests encountered in agriculture, forestry, the protection of stored products and materials, and the sanitation sector, particularly insects, arachnids, and nematodes. It is active against both normally susceptible and resistant species, and against all or individual developmental stages, and also achieves a surprising "synergistic" effect in preventing or controlling pests.

[0069] This invention also provides the use of the insecticidal composition of this invention for the prevention or control of pests. As used herein, the term "pest" means any organism that can cause damage to the normal state of a plant. This includes insects (Insecta), arachnids (Arachnida), and nematodes (Nematoda).

[0070] The class Insecta includes Lepidoptera, Coleoptera, Diptera, Hemiptera, Homoptera, Hymenoptera, Thysanoptera, Isopoda, Diplopoda, Chilopoda, Syndrome, Thysanura, Collembola, Collembola, Orthoptera, Blattodea, Dermoptera, Isoptera, and Pseudocoptera.

[0071] Lepidoptera pests: Pyralidae (e.g., rice stem borer *Chilosuppressalis* (walker), rice leaf roller *Tryporyza incertulas* (walker)), rice leaf roller *Cnaphalocrocismedinalis* Guenee, Chinese cabbage leaf roller *Hellullaundalis*, peach fruit borer *Conogethes punctiferlis*); Pieridae (e.g., cabbage white butterfly *Pieris*). (rapae), Citrus Swallowtail (papilioxuthus), White-faced Butterfly (pierisrapaecrucivora), Straight-striped Rice Skipper (parnaraguttata); Arctiidae such as the American White Moth (hyphantriacunea); Noctuidae such as the Prickly-spotted Armyworm (trichoplusiani), Cabbage Armyworm (mamestrabrassicae), Beet Armyworm (spodopteraexigua), Spodopteral Itura, Cotton Bollworm (helicoverpaarmigera), Oriental Armyworm (Pseudaletia separate), Cutworm (Agrotis) ipsilon; Tortricidae, such as the tea leaf roller (adoxophyes oranafasciata), apricot yellow leaf roller (archipsfuscocureanus), and tea long leaf roller (homonamagnanima); Plutellidae, such as the diamondback moth (plutellaxylotella); Gelechiidae, such as the cotton bollworm (pectinophoragossypiella) and pink bollworm (Pink bollworm);

[0072] Hemiptera pests, such as those from the families Aphididae, Adelgidae, or Phylloxaceridae, including the tobacco aphid (Myzus persicae), cotton aphid (Aphis gossypii), black bean aphid (Aphis fabae), corn aphid (Aphis maidis) (corn leaf aphid), pea aphid (Acyrthosiphon pisum), eggplant webless aphid (Aulacorthum solani), bean aphid (Aphis craccivora), euphorbiae macrosiphumeuphorbiae, wheat webless aphid (Macrosiphum avenae), wheat webless aphid (Metopolophium dirhodum), rice webless aphid (Rhopalosiphum padi), wheat two-forked aphid (Schizaphis graminum), cabbage aphid (Brevicoryne brassicae), turnip aphid (Lipaphis erysimi), and spirea aphid (Aphis). The species include: citricola, rose apple aphid (Rosy apple aphid), apple woolly aphid (Eriosoma lanigerum), citrus two-forked aphid (Toxoptera aurantii), and large citrus aphid (Toxoptera citricidus); Cicadidae, such as black-tailed leafhopper (Nephotettix cincticeps); Delphacidae, such as gray planthopper (Laodelphax striatellus), brown planthopper (Nilaparvata lugens), and white-backed planthopper (Sogatella furcifera); Pentatomidae, such as white-spotted bug (Eysarcoris ventralis) and green rice bug (Nezara viridula); and Aleyrodidae, such as tobacco whitefly (Bemisia). The whitefly (Trialeurodesvaporariorum); Scale insects (Diaspididae, Margarodidae, Ortheziidae, Aclerdiae, Dactylopiidae, Kerridae, Pseudocoddidae); Coccidae; Eriococcidae; Asterolecaniidae; Lecanodiaspididae;Or Cerococcidae, such as Pseudococcus comstocki and Planococcus citri Risso; Psyllidae, such as pear psyllid (psyllapyrisuga) and citrus psyllid (diaphorinatabaci);

[0073] Coleoptera pests, such as: rice weevil (Sitophilus oryzaelinne), citrus leaf miner (Podagricomelanigricollis Che), corn weevil (S. zeamails), grain weevil (S. granarius), large ape leaf beetle (Cabbageleaf beetle), small ape leaf beetle (Daikon leaf beele), flea beetle (flea beetle), grape flea beetle (Altica chalybea), striped flea beetle (phyllotretastriolata), cucumber flea beetle (Epitrix cucumeris), tobacco flea beetle (Ehirtipennis), eggplant flea beetle (E. fuscula), cucumber beetle (Aula cophora ndica (Gemlin), mustard leaf beetle (Phaedon cochleariae), rice water weevil (Lissorhoptrus oryzophilus), Callosobruchuyschienensis, yellow mealworm (Tenebrio molitor), and corn root leaf beetle (Diabrotica). The following beetles are listed: *Vibriferavirgifera*, *Diabrotica undecimpunctata howardi*, *Anomalacuprea*, *Anomala rufocuprea*, *Phyllotreta striolata*, *Aulacophora femoralis*, *Leptinotarsa ​​decemlineata*, *Oulema oryzae*, *bostrychidae*, and *Cerambycidae*.

[0074] Diptera pests, such as: rice leafminer (Agromyza oryzae), barley water fly (Hydrilla agriseola), gerbera leafminer (Liriomyza trifolii), pea leafminer (Chromatomyia horticola), tomato leafminer (Liriomyza bryoniae), gray field fly (Delia platura), onion field fly (Delia antiqua), Mediterranean fruit fly (Ceratis capiata wiedgman), apple fruit fly (Rhagoletis pomonella), and cherry fruit fly (R. cingulata).

[0075] Coleoptera pests, such as rice water weevil (Lissorhoptrus oryzophilus), Callosobruchuys chienensis, yellow mealworm (Tenebrio molitor), corn root leaf beetle (Diabrotica virgifera virgifera), cucumber beetle (Diabrotica undecimpunctata howardi), green beetle (Anomala cuprea), red copper beetle (Anomala rufocuprea), yellow striped vegetable flea beetle (Phyllotretastriolata), cucumber beetle (Aulacophora femoralis), potato beetle (Leptinotarsadecemlineata), rice leaf beetle (Oulema oryzae), bostrychidae, and longhorn beetles (Cerambycidae);

[0076] Pests belonging to the order Acari. Examples include the citrus spider mite (panonychuscitri), the carmine spider mite (Tetranychuscinnabarinus), the apple spider mite (panonychusulmi), the two-spotted spider mite (tetranychusurticae), the hawthorn spider mite (tetranychusviennensis), the needle-leaved small spider mite (oligonychusununguis), the citrus leaf mite (eotetranychuskankitus), the purple short-haired mite (brevipalpusphoenicis), and the alfalfa moth (bryobi). *Aceriatulipae*, *colomerusvitis*, *calacaruscarinatus*, *polyphagotarsonemuslatus*, *rhizoglyphusrostochiensis*, *Acarussiro*, *Aceriasheldoni*, *Aculusschlechtendali*, *Tetranychus* spp., *Panonychus* spp., *Phyllocoptruta* spp., *Brevipalpus* spp., etc.

[0077] Thysanopteran pests, such as palm thrips, western flower thrips (Frankliniella occidentalis), tobacco thrips (Thrips alliorum (Priesner)), yellow-breasted thrips (Thrips hawaiiensis (Morgan), yellow tea thrips (Scirtothripsdorsalis Hood), and flower thrips (Frankliniella intonsa (Trybom)).

[0078] Orthoptera (Orthoptera) pests, such as Acrididae (Grasshoppers); stink bug (megacoptapunctatissimum), cabbage bug (eurydemarugosum), large-spined white-spotted bug (eysarcorislewisi), white-spotted bug (eysarcorisparvus), rice green bug (nezaraviridula), Plautiastali, stink bug (halymorphamista), rice thorny-edged bug (cletuspunctiger), Chinese rice thorny-edged bug (leptocorisachinensis), cuckoo lace bug (stephantispyrioides), and red-bearded mirid bug (trigonotyluscoelestialium).

[0079] Hymenoptera pests, such as the yellow-winged cabbage leaf bee (athaliarosaeruficornis), the rose leaf bee (argepagana), the black mountain ant (formica japonica), and the chestnut gall bee (dryocsmuskuriphilus).

[0080] Isopoda, for example, gardenia leech (Oniscus asellus), woodlice (Armadilliudium vulgare), and ball beetle (Porcellioscaber).

[0081] Diplopod pests, for example, Blaniulusguttulatus.

[0082] Chilopod pests, for example, centipedes (Geophilus carpophagus Scutigera spp.).

[0083] Syngenes pests, such as the white pine beetle (Scutigerella immaculata).

[0084] Pests of the order Thysanura, such as silverfish (Lepismasaccharina).

[0085] Collembola pests, such as the armed springtail (Onychiurus sarmatus).

[0086] Orthoptera pests, such as house crickets (Acheta domesticus), crickets (Gryllotalpa spp.), migratory locusts (Locustamigratoriamigratorioides), black locusts (Melanopluss pp.), and desert locusts (Schistocercagregaria).

[0087] Blattodea pests, such as the Oriental cockroach (Blatta orientalis), the American cockroach (Periplaneta americana), the Madeira cockroach (Leucophae amadeerae), and the German cockroach (Blattella germanica).

[0088] Dermaptera pests, such as the European ball cactus (Forficula auricularia).

[0089] Isoptera pests, such as species of the genus *Reticulitermes*.

[0090] The order Anoplura (Phthiraptera) includes genera such as Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., and Trichodectes spp.

[0091] Representative organisms of the class Nematoda include those selected from genera such as *Meloidogyne* spp., *Heterodera* spp., *Globodera* spp., *Radipoholus* spp., *Pratylenchus* spp., and *Longidorus* spp. Among these, *Heterodera* (soybean cyst nematode), *golboderarostochiensis* (potato golden nematode), and *meloidogyne incognita* (southern root-knot nematode) are preferred.

[0092] The insecticidal composition of the present invention is particularly effective against Lepidoptera, Hemiptera, Diptera, Thysanoptera, and Acari pests.

[0093] In particular, the insecticidal composition of the present invention is especially effective against the following pests; specifically including the following pests:

[0094] Noctuidae includes species such as Trichoplusiani, Mamestrabrassicae, Spodopteraexigua, Spodopteralitura, Helicoverpaarmigera, Pseudaletia separate, and Agrotisipsilon.

[0095] Examples of moths in the family Tortricidae include the tea leafroller (adoxophyes oranafasciata), the apricot leafroller (archipsfuscocureanus), and the tea long leafroller (homonamagnanima).

[0096] Plutellidae family, such as the diamondback moth (Plutellaxylotella);

[0097] Whiteflies include species such as the cabbage whitefly (Aleurodes brassicae), the tobacco whitefly (Bemisia tabaci), and the greenhouse whitefly (Trialeurodes vaporariorum);

[0098] Planthopper family (Delphacidae), such as the gray planthopper (Laodelphax striatellus), the brown planthopper (Nilaparvata lugens), and the white-backed planthopper (Sogatella furcifera);

[0099] Tetranychidae family includes species such as Tetranychuscinnabarinus, Tetranychusurticae, Tetranychusviennensis, Oligonychusununguis, and Eotetranychuskankitus.

[0100] Panonychus spp., such as the citrus panonychuscitri and the apple panonychusulmi.

[0101] Thripidae includes species such as palm thrips, western flower thrips (Frankliniella occidentalis), tobacco thrips (Thrips alliorum (Priesner)), yellow-breasted thrips (Thripshawaiiensis (Morgan), yellow tea thrips (Scirtothrips dorsalis Hood), and flower thrips (Frankliniella intonsa (Trybom)).

[0102] Aphids include the tobacco aphid (Myzus persicae), cotton aphid (Aphis gossypii), cabbage aphid (Brevicorynebrassicae), and rice constrictor aphid (Rhopalosiphum padi);

[0103] Cerococcidae, for example, Pseudococcus comstocki and Planococcus citri Risso.

[0104] In particular, the insecticidal composition of the present invention exhibits a surprising "synergistic" effect on the prevention or control of pests of the families Diamondback Moth, Tortricidae, Noctuidae, Planthopper, Whitefly, Tetranychidae, Thrips, Aphids, and Hydnoclidae, as well as their larvae and eggs.

[0105] The insecticidal composition of the present invention unexpectedly exhibits extremely high activity in preventing or controlling pests of the families Plutella, Helicoptera, Noctuidae, Planthoppers, Whiteflies, Tetranychidae, Thrips, Aphids, and Hydnoclidae, as well as their larvae and eggs, when applied to plants, plant propagation materials, or soil in which plants grow.

[0106] The insecticidal composition of the present invention exhibits excellent control efficacy against pests of the families Diamondback Moth, Tocopheridae, Noctuidae, Planthopper, Whitefly, Tetranychidae, Thrips, Aphids, and Chrysalis at low doses, as well as their larvae and eggs.

[0107] On the other hand, the present invention also provides the use of an insecticidal composition for the prevention or control of pests of the families Prunella vulgaris, Helicoptera, Noctuidae, Planthoppers, Whiteflies, Tetranychidae, Thrips, Aphids, and Chrysalis, as well as their larvae and eggs.

[0108] This invention provides an insecticidal composition for the prevention or control of pests such as diamondback moth, beet leafminer, carmine spider mite, whitefly, tobacco thrips, tobacco aphid, and their larvae and eggs.

[0109] The insecticidal composition of the present invention can be applied to any and all developmental stages of pests, such as eggs, larvae, pupae, and adults. Pests can be controlled by bringing the target pest, its food source, habitat, breeding ground, or other location into contact with an effective amount of the insecticidal composition of the present invention.

[0110] "Place" refers to the plant, plant propagation material, soil, area, material, or environment in which pests grow or may grow.

[0111] "Effective insecticidal dose" refers to the amount of the insecticidal composition of the present invention required to achieve an observable effect on growth, including effects of death, prevention or removal, destruction or reduction of the occurrence and activity of animal pests. The effective insecticidal dose of the various insecticidal compositions used in the present invention can vary. The effective insecticidal dose of the composition will also vary depending on key conditions such as the desired insecticidal effect and duration, weather, target species, location, and method of application.

[0112] According to the present invention, all plants and plant parts can be processed. "Plant" here should be understood to mean all plants and plant populations, such as desired and undesirable wild plants or crops (including naturally growing crops). Crops can be plants obtained through conventional breeding and selection methods, or plants obtained through biotechnology and genetic engineering methods or combinations thereof, including transgenic plants and plant cultivars that may or may not be protected by a plant breeder's certificate. Plant parts should be understood to mean all above-ground and underground parts and plant organs such as seedlings, leaves, flowers, and roots; examples that may be mentioned include leaves, needles, stems, trunks, flowers, fruiting bodies, fruits, and seeds, as well as roots, tubers, and rhizomes. Plant parts also include harvested plants and asexually and sexually propagated materials, such as seedlings, tubers, rhizomes, cuttings, and seeds.

[0113] As described above, the present invention can process all plants and their parts. The present invention is particularly preferred for processing plant cultivars that are commercially available or in use in all cases.

[0114] The insecticidal composition of the present invention shows particularly advantageous effects when used on, for example, the following plants:

[0115] Crops: corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, sugar beets, bok choy, cabbage, rapeseed, sunflower, sugarcane, tobacco, etc.

[0116] Vegetables: Solanaceae vegetables (eggplant, tomato, green pepper, chili pepper, potato, etc.), Cucurbitaceae vegetables (cucumber, pumpkin, summer squash, watermelon, cantaloupe, etc.), Brassica vegetables (rapeseed, radish, turnip, wasabi, turnip, cabbage, round cabbage, mustard greens, cauliflower, broccoli, etc.), Asteraceae vegetables (burdock, wormwood, artichoke, lettuce, etc.), Liliaceae vegetables (scallion, onion, garlic, asparagus, etc.), Umbelliferae vegetables (carrot, parsley, dry parsnip, parsnip, etc.), Chenopodiaceae vegetables (spinach, lettuce, etc.), labiate vegetables (perilla, mint, basil, etc.), strawberry, sweet potato, yam, taro, etc.

[0117] Fruit trees: pome fruits (apple, pear, Japanese pear, papaya), stone fruits (peach, plum, nectarine, plum, yellow peach, apricot, prune, etc.), citrus fruits (Senju mandarin orange, orange, lemon, lime, grapefruit, etc.), nuts (chestnut, walnut, hazelnut, almond, cashew, etc.), berries (red berries, blackberries), grapes, persimmons, olives, loquats, bananas, coffee, dates, coconuts, oil coconuts.

[0118] Trees other than fruit trees: tea, mulberry, flowering trees (rhododendron, camellia, hydrangea, oil tea, Japanese anise, cherry, crape myrtle, osmanthus, etc.), street trees (birch, ginkgo, lilac, maple, oak, poplar, bauhinia, sweetgum, sycamore, beech, Japanese cedar, fir, Japanese hemlock, juniper, pine, spruce, yew, elm, etc.), coral tree, podocarpus, cedar, Japanese cypress, croton, photinia, etc.

[0119] Turfgrasses include: Zoysia japonica (Zoysia japonica, Zoysia sulphurea, etc.), Bermuda grasses (Bermudagrass, etc.), Creeping bentgrass (Giant creeping bentgrass, creeping bentgrass, dryland bentgrass, etc.), Bluegrass (Kentucky bluegrass, birdgrass, etc.), Festuca (Tall festuca, red festuca, creeping red festuca, etc.), Ryegrass (Dysalis, Ryegrass, etc.), Wild grass, Tigrass, etc.

[0120] Other: Flowers (roses, carnations, chrysanthemums, bellflowers, pink carnations, dandelions, calendula, sage, petunia, verbena, tulips, gentians, lilies, pansies, cyclamen, orchids, lily of the valley, lavender, violets, kale, primroses, euphorbias, daisies, orchids, begonias, etc.), biofuel plants (jatropha, safflower, flaxseed, switchgrass, miscanthus, reed, kenaf, cassava, willow, etc.), ornamental plants, etc.

[0121] The insecticidal composition of this invention has good plant compatibility and is suitable for controlling pests, especially insects (Insecta), arachnids (Arachnida), nematodes (Nematoda), as well as fungi, rodents, and microorganisms; particularly pests of the families Plutella, Tocopheridae, Noctuidae, Planthoppers, Whiteflies, Tetranychidae, Thrips, Aphids, and Chrysalis, as well as their larvae and eggs. It is preferably suitable for foliar treatment, soil treatment, and seed treatment.

[0122] On the other hand, the present invention also provides a method for preventing or controlling pests and their larvae and eggs, by applying the insecticidal composition of the present invention to a target useful plant, a target pest or its environment, or the propagation material of the target useful plant. This can be done before or after the plant, plant propagation material, or environment is infested by the pest.

[0123] The term "plant propagation material" should be understood to refer to all reproductive plant parts, such as seeds, which can be used to propagate the latter, and plant materials such as cuttings or tubers (e.g., potatoes). Therefore, plant parts as used herein include plant propagation material. Examples that may be mentioned include, for instance, seeds, roots, fruits, tubers, bulbs, rhizomes, and plant parts. Germination and viable plants are suppressed after sprouting from the soil or after emergence. Young plants may be protected by whole or partial treatment with immersion before transplanting.

[0124] The plant propagation material is seedlings, rhizomes, nursery seedlings, cuttings, or seeds. Seeds are preferred.

[0125] The insecticidal composition of the present invention can be applied to seeds, plants or fruits of plants or soil in which plants grow or soil suitable for plant growth.

[0126] A method for protecting seeds includes contacting the seeds with an insecticidally effective amount of the insecticidal composition of the present invention before sowing and / or after germination.

[0127] The plants mentioned can include: plant stems and leaves, plant flowers, plant fruits, etc.

[0128] The seeds mentioned are selected from soybean, wheat, barley, rye, sorghum, peanut, sunflower, sugarcane, tobacco, rice, rapeseed, bok choy, cabbage, beet, tomato, cowpea, carrot, cotton and corn seeds.

[0129] Therefore, the present invention provides a method for protecting seeds, seedling roots and branches from soil and leaf insect infestation, comprising contacting the seeds with an effective amount of the insecticidal composition of the present invention before sowing and / or after germination.

[0130] The present invention also provides a method for controlling or preventing pests and their larvae and eggs in plant propagation material and subsequently growing plant organs, plant parts and / or plants, comprising applying the insecticidal composition of the present invention to the plant propagation material or its environment. Seeds are preferably the plant propagation material.

[0131] Most damage to crops caused by pests occurs as early as during seed development, storage, sowing, and germination. This stage is particularly critical because the roots and seedlings of growing plants are especially sensitive, and even minor damage can lead to the death of the entire plant. Therefore, protecting seeds and germinating plants using appropriate compositions is of particular importance.

[0132] This invention also specifically relates to a method for protecting seeds and germinating plants from pests and their larvae and eggs by treating seeds with the insecticidal composition of this invention. The method of protecting seeds and germinating plants from pests of the families Plutella, Tocopheridae, Noctuidae, Planthoppers, Whiteflies, Tetranychidae, Thrips, Aphids, and Gypsydae, as well as their larvae and eggs, comprises treating the seeds simultaneously with compound I and compound II. It also includes a method of treating the seeds with compound I and compound II at different times.

[0133] A method for preventing or controlling pests and their larvae and eggs involves treating seeds intended to grow into plants with a synergistically effective amount of the insecticidal composition of the present invention before sowing and / or after germination.

[0134] The present invention also relates to the use of the insecticidal composition of the present invention for treating seeds to protect said seeds and plants growing therefrom from pests and their larvae and eggs.

[0135] Furthermore, the present invention also relates to seeds treated with the insecticidal composition of the present invention to obtain seeds protected from pests and their larvae and eggs.

[0136] The present invention also relates to seeds treated simultaneously with compound I and compound II. The present invention also relates to seeds treated with compound I and compound II at different times. For seeds treated with compound I and compound II at different times, the various active compounds of the insecticidal composition of the present invention may be present in different layers on the seed. The layers containing compound I and compound II may optionally be separated by an intermediate layer. The present invention also relates to seeds in which compound I and compound II are applied as coating components or as one or more additional layers outside a coating.

[0137] The insecticidal composition of the present invention can be applied to seeds in any physiological state. Preferably, the seeds are in a sufficiently durable state to withstand treatment without damage. Generally, the seeds can be those harvested from the field, removed from the plant, or separated from any rachis, stem, outer skin, and surrounding pulp or other non-seed plant material. The seeds are also preferably biologically stable to the extent that treatment does not cause biological damage to them. Treatment can be applied to the seeds at any time between seed harvesting and sowing or during the sowing process. The seeds can also be pre-germinated before or after treatment.

[0138] Seeds treated with the insecticidal composition of the present invention can be stored, managed, sown, and cultivated.

[0139] Seed treatment occurs on unsown seeds, the term "unsown seeds" intended to include seeds at any stage between seed harvest and sowing in the ground for plant germination and growth purposes. Preferably, the treatment occurs before sowing, so that the sown seeds have been pretreated with the combination. In particular, seed coating or seed granulation is preferred in the treatment of the combinations of the present invention. After treatment, the components of each combination adhere to the seeds and are therefore useful for pest control.

[0140] Seed treatment methods include all methods known to those skilled in the art suitable for treating seeds, such as seed dressing, seed coating, seed soaking, seed coating, multi-layer seed coating, seed hulling, seed soaking, seed powdering, and seed granulation.

[0141] The composition of the present invention can be applied to seeds, plants or fruits of plants or soil in which plants grow or soil suitable for plant growth.

[0142] The present invention also provides a method for preventing or controlling pests and their larvae and eggs, comprising applying the insecticidal composition of the present invention to seeds, target useful plants, or soil in which plants grow or soil suitable for plant growth.

[0143] On the other hand, the present invention also provides a method for preventing or controlling pests and their larvae and eggs by applying the insecticidal composition of the present invention to the soil before, after, or before and after seed germination and / or directly to the soil in contact with the plant roots or to soil suitable for plant growth.

[0144] This invention also provides a method for protecting plants from pests and their larvae and eggs, comprising applying the insecticidal composition of this invention to the environment, habitat, or storage area where the useful plant grows. The plant growing environment and habitat refer to the support structure that enables crops to take root and grow, such as soil and water. Specific raw materials can include, for example, sand, pumice, vermiculite, diatomaceous earth, agar, gels, polymers, asbestos, sawdust, bark, etc. Soil is preferred.

[0145] This invention also provides a method for protecting plants from pests of the families Prunella vulgaris, Helicoptera, Noctuidae, Planthoppers, Whiteflies, Tetranychidae, Thrips, Aphids, and Chrysalis, as well as their larvae and eggs, comprising applying active components Compound I and Compound II in combination, separately, or sequentially. When applied separately, the order generally has no effect on the outcome of the control measure.

[0146] A method for preventing or controlling pests and their larvae and eggs, comprising applying compound I and compound II separately, sequentially or simultaneously.

[0147] The present invention also provides a method for protecting useful plants from pests and their larvae and eggs, comprising applying a combination comprising compound I and compound II in any desired order or simultaneously to the target useful plant or its environment, the target pest or its environment, and the propagation material of the target useful plant.

[0148] The insecticidal compositions of the present invention include not only ready-to-use compositions that can be applied to plants or plant propagation materials using suitable devices, but also commercially available concentrates that must be diluted with water before application.

[0149] The insecticidal composition of the present invention can be applied undiluted or diluted with water.

[0150] This invention provides a method for preventing or controlling pests and their larvae and eggs, wherein the insecticidal composition of this invention is applied to a target useful plant or its environment, or to the reproductive material of the target useful plant. Other pesticides may be applied independently of each other before, simultaneously with, or after the application of compounds I and II, or when compounds I and II are applied separately.

[0151] The insecticidal compositions of the present invention are commonly and advantageously applied at the following dosages:

[0152] For foliar treatment: 0.1-10000 g / ha, preferably 10-1000 g / ha, more preferably 10-500 g / ha, and even more preferably 10-300 g / ha;

[0153] For seed treatment: 1-1000g / 100kg of seeds, preferably 100-1000g / 100kg of seeds;

[0154] For soil treatment: 1-10000 g / ha, preferably 10-1000 g / ha.

[0155] The above dosage is only a general exemplary dosage. In actual application, those skilled in the art will adjust the application rate according to the actual situation and needs, especially according to the nature of the plant or crop to be treated and the pest situation.

[0156] Methods of treating target pests, target useful plants, or seeds, or soil with the insecticidal composition of the present invention include, for example, spreading treatment, soil treatment, surface treatment, and fumigation treatment. Spreading treatment includes, for example, spreading, spraying, misting, atomizing, or granular application. Soil treatment includes, for example, soil irrigation and soil mixing. Surface treatment includes, for example, coating or covering. Fumigation treatment includes, for example, covering the soil with a polyethylene film after injection.

[0157] Applicants typically use the insecticidal compositions of the present invention in backpack sprayers, spray cans, spray aircraft, or irrigation systems. The insecticidal compositions of the present invention are usually formulated with water, buffers, and / or other adjuvants to the desired application concentration to obtain a ready-to-use spray.

[0158] The total amount of active ingredient in the insecticidal composition of the present invention can be selected according to specific factors to achieve the desired effect. These factors include, for example, the formulation, the target organism, and the method of application.

[0159] The present invention provides an insecticidal composition containing active ingredients compound I and compound II, wherein the total weight of compound I and compound II accounts for 1%-90% by weight of the insecticidal composition, preferably 5%-80%, more preferably 5%-70%, even more preferably 5%-60%, more preferably 5%-50%, more preferably 10%-50%, and more preferably 10%-40%.

[0160] An insecticidal composition comprising active ingredients compound I and compound II, wherein the total weight of compound I and compound II constitutes, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, or 90% of the total weight of the insecticidal composition.

[0161] The insecticidal composition of the present invention may optionally contain agronomically acceptable adjuvants such as surfactants and / or fillers. Preferably, the adjuvants are one or a mixture of dispersants, wetting agents, antifreeze agents, thickeners, defoamers, disintegrants, binders, and auxiliary carriers.

[0162] According to the present invention, the term "filler" refers to a natural or synthetic organic or inorganic compound that can be combined or combined with an active compound to make it easier to apply to an object (e.g., a plant, crop, or grass). Therefore, the filler is preferably inert and should at least be agronomically acceptable. The filler may be a solid or a liquid.

[0163] The inactive filler used in this invention can be either solid or liquid.

[0164] Examples of solid fillers that can be used include: talc, bentonite, clay, kaolin, diatomaceous earth, silica, calcium carbonate, acid clay, silica, zeolite, magnesia, pumice, ammonium sulfate, sodium sulfate, and urea.

[0165] Materials that can be used as liquid fillers include, for example, water, isopropanol, butanol, tetrahydrofuran, ethylene glycol, propylene glycol, ethyl acetate, methyl oleate, dimethylformamide, dimethylacetamide, dimethyl sulfoxide, and vegetable oils.

[0166] Surfactants can be used to emulsify, disperse, solubilize, and / or wet the active ingredient compound. Examples of surfactants include fatty alcohol polyoxyethylene ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene higher fatty acid esters, phosphate esters of polyoxyethylene alcohols or phenols, fatty acid esters of polyols, naphthalene sulfonic acid polymers, lignin sulfonates, branched copolymers of polymeric combs, butyl naphthalene sulfonates, alkyl aryl sulfonates, alkyl sulfosuccinates, oils, fatty alcohols and ethylene oxide condensates, polyacrylates of alkyl naphthalene sulfonates, protein hydrolysates, suitable oligosaccharides, or polymers, such as those based on ethylene monomers, acrylic acid, polyoxyethylene and / or polyoxypropylene, or combinations thereof with, for example, (poly)ols or (poly)amines.

[0167] To disperse, stabilize, and adhere the active ingredient compounds, auxiliary agents such as xanthan gum, magnesium aluminum silicate, gelatin, starch, cellulose methyl ether, polyvinyl alcohol, polyvinyl acetate, and natural phospholipids (such as cephalin and lecithin), as well as synthetic phospholipids, bentonite, and sodium lignosulfonate can be used.

[0168] Antifreeze agents can include ethylene glycol, propylene glycol, glycerol, and sorbitol. For antiflocculation in suspended products, additives such as naphthalene sulfonic acid polymers and polyphosphates can be used. For defoaming, silicone defoamers can be used. To improve the flowability of solid products, additives such as paraffin wax, stearates, and alkyl phosphates can be used.

[0169] Colorants that can be used include inorganic pigments such as iron oxide, titanium dioxide, and Prussian blue; organic pigments / dyes such as alizarin dyes, azo dyes, and metallic phthalocyanine dyes; and trace elements such as iron salts, manganese salts, boron salts, copper salts, cobalt salts, molybdenum salts, and zinc salts.

[0170] Optionally, it may also contain other additional components, such as protective colloids, adhesives, thickeners, thixotropic agents, penetrants, stabilizers, and masking agents.

[0171] The insecticidal compositions of the present invention can be used on their own, or in formulation or preparation form according to their respective physical and / or chemical properties, such as aerosols, microcapsule suspensions, cold fogging agents, hot fogging agents, microcapsule granules, fine granules, seed treatment suspensions, ready-to-use solutions, powders, emulsifiable concentrates, oil-in-water emulsions, water-in-oil emulsions, large granules, microparticles, oil-dispersible powders, oil suspensions, oils, foaming agents, pastes, seed coating agents, colloidal suspensions, suspension emulsions, water-soluble solvents, suspensions, wettable powders, soluble powders, powders and granules, water-soluble granules or tablets, water-soluble powders for seed treatment, wettable powders, natural and synthetic products impregnated with active ingredients, microcapsules in polymeric materials and seed coating materials, and ultra-low volume cold fogging agents and hot fogging formulations.

[0172] The preferred formulations of the insecticidal composition of the present invention are emulsifiable concentrates, aqueous suspensions, oil suspensions, seed-treated dry powders, seed-treated suspensions, water-dispersible granules, wettable powders, suspension emulsions, water-in-oil emulsions, microcapsule suspensions, dry suspensions, ultra-low volume liquids, microparticles, and microemulsions.

[0173] The insecticidal composition of the present invention can also be used in combination with other active ingredients, such as fungicides, bactericides, attractants, insecticides, acaricides, nematicides, growth regulators, herbicides, safeners, fertilizers, or chemical pheromones.

[0174] The formulations described in this invention can be prepared by mixing the active ingredient with conventional additives in a known manner. These conventional additives include conventional fillers, solvents or diluents, emulsifiers, dispersants, and / or binders or fixatives, wetting agents, waterproofing agents, and, if desired, driers, colorants, stabilizers, pigments, defoamers, preservatives, thickeners, water, and other processing aids.

[0175] The insecticidal compositions of the present invention include not only those that can be immediately applied to the object to be treated using suitable equipment such as spraying or dusting equipment, but also concentrated commercial compositions that need to be diluted before application to the object.

[0176] The insecticidal composition of the present invention can be formulated as an application-suitable preparation in the form of a composition of its active ingredient compounds, or in the form of a combination of appropriate doses of a commercially available formulation.

[0177] Formulation Examples

[0178] Example 1 Wettable Powder

[0179] Compound I 5%

[0180] Spinosad 2.5%

[0181] Sodium lauryl sulfate 1%

[0182] Sodium lignin sulfate 9%

[0183] Kaolin content increased to 100%.

[0184] The above components are mixed in proportion, and then ground and pulverized to prepare a wettable powder.

[0185] Example 2: Aqueous Suspension

[0186] Compound I 10%

[0187] 10% chlorfenapyr

[0188] 5% polystyrene phenyl ether sulfate

[0189] 1% xanthan gum aqueous solution 1%

[0190] 1.5% bentonite

[0191] 5% propylene glycol

[0192] Polysiloxane defoamer 0.05%

[0193] Replenish water to 100%.

[0194] All ingredients except the 1% xanthan gum aqueous solution were premixed with an appropriate amount of water, and the mixture was then ground using a wet mill. Finally, the 1% xanthan gum aqueous solution and the remaining water were added to the ground product to prepare an aqueous suspension.

[0195] Example 3: Emulsifiable Oil

[0196] Compound I 3%

[0197] Bifenthrin 3%

[0198] 8% ethoxylated fatty alcohols

[0199] Calcium dodecylbenzenesulfonate 5%

[0200] N,N-Dimethylformamide 20%

[0201] SOLVESSO 200 replenished to 100%

[0202] The above components are mixed and dissolved evenly to obtain an emulsion.

[0203] Example 4 Water-dispersible granules

[0204] Compound I 25%

[0205] 5% abamectin

[0206] 2% Modified sodium lignosulfonate

[0207] 10% talc

[0208] Fill the clay to 100%.

[0209] The above ingredients are mixed and ground evenly, then a certain amount of water is added, mixed, extruded and shaped, and dried and sieved to obtain water-dispersible granules.

[0210] Example 5: Aqueous Suspension

[0211] Compound I 10%

[0212] 10% Ethephon

[0213] 3% Polyoxyethylene styrene phenyl ether

[0214] 3% sodium alkylnaphthalene sulfonate formaldehyde condensate

[0215] 1% xanthan gum aqueous solution 1%

[0216] 0.35% bentonite

[0217] Propylene glycol 7%

[0218] Polysiloxane defoamer 0.03%

[0219] Replenish water to 100%.

[0220] All ingredients except the 1% xanthan gum aqueous solution were premixed with an appropriate amount of water, and the mixture was then ground using a wet mill. Finally, the 1% xanthan gum aqueous solution and the remaining water were added to the ground product to prepare an aqueous suspension.

[0221] Example 6 Aqueous Suspension

[0222] Compound I 4%

[0223] Flupyradifonil 20%

[0224] Sodium lignin sulfate 8%

[0225] 1% xanthan gum aqueous solution 1%

[0226] 0.35% bentonite

[0227] Propylene glycol 7%

[0228] Polysiloxane defoamer 0.05%

[0229] Replenish water to 100%.

[0230] All ingredients except the 1% xanthan gum aqueous solution were premixed with an appropriate amount of water, and the mixture was then ground using a wet mill. Finally, the 1% xanthan gum aqueous solution and the remaining water were added to the ground product to prepare an aqueous suspension.

[0231] The above proportions are by weight percentage.

[0232] Biological test cases

[0233] The expected effect of a specific combination of two active components can be calculated using the so-called "Colby formula" (see SRColby, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15, 20-22):

[0234]

[0235] X represents the control effect when the active ingredient of compound I is used at a dosage of mg / ha or a concentration of m ppm, expressed as a percentage of the untreated control.

[0236] Y represents the control effect when active ingredient compound II is used at a dosage of ng / ha or a concentration of nppm, expressed as a percentage of the untreated control.

[0237] E represents the control efficacy when active ingredient compounds of formula I and II are used at dosages of m and ng / ha or concentrations of m and n ppm, expressed as a percentage of the untreated control.

[0238] If the actual control effect exceeds the calculated value, then the lethal effect of the composition is superadditive, that is, there is a synergistic effect.

[0239] Experimental Example 1: Diamondback Moth Experiment

[0240] Drug solution preparation: Prepare a stock solution of compound I and compound II using acetone, and then dilute it with 0.1% Tween-80 aqueous solution to the required concentration.

[0241] Select second-instar diamondback moth larvae that have been continuously reared indoors and are in the same physiological state. Select cabbage leaves of uniform growth to make suitable leaf saucers.

[0242] Immerse the leaf disc in the test solution for 10 seconds, then remove and air dry. Place the leaf disc in a petri dish containing moisturizing filter paper, and inoculate with test insects. Inoculate approximately 10 test insects per replicate. Each treatment is repeated 4 times. A blank control is provided, consisting of a treatment without the test solution (containing organic solvent and emulsifier).

[0243] The treated test insects were covered and placed in a container at 25±1°C. o They were raised and observed in a constant temperature incubator with a relative humidity of 60%-80% and a light cycle of L:D=(16:8)h.

[0244] The results were checked after 48 hours in the incubator. The criterion for determining death was: the worm was considered dead if it did not react at all or could not react normally when gently touched with a needle.

[0245] During the experiment, the preparation of the drug solution must be accurate to minimize errors; the operation should be skillful and quick, and the experimental operation procedures should be followed to ensure the accuracy of the experiment. If the mortality rate of the blank control experiment exceeds 20%, the experiment must be repeated.

[0246] Calculation method:

[0247] Mortality rate (%) = (Number of live worms before treatment - Number of live worms after treatment) / Number of live worms before treatment × 100

[0248] Prevention and control efficacy % = ((mortality rate of treatment group - mortality rate of control group) / (100 - mortality rate of control group)) × 100

[0249] Table 1. Effects of the combination of compound I and compound II on diamondback moth.

[0250]

[0251] Experimental Example 2: Thrips Experiment

[0252] Drug solution preparation: Prepare a stock solution of compound I and compound II using acetone, and then dilute it with 0.1% Tween-80 aqueous solution to the required concentration.

[0253] Tobacco thrips was used as the test pest. Collected tobacco thrips were inoculated into potted eggplants in a greenhouse for long-term rearing. Before the experiment, tobacco thrips were selected by microscopic examination and reared on greenhouse-grown eggplant plants (no other thrips species were present). Rearing conditions included a glass mesh house, natural light, and a cycle of approximately 16 (L):8 (D). The maximum temperature was 28°C. o C, minimum is 15 o C. Humidity ranged from a maximum of 95% to a minimum of 65%. F1 generation adults were selected for testing. Indoor experiments were conducted in groups of 20-40 insects, following the immersion method (NY / T 1154.6-2006).

[0254] Cut eggplant leaves containing adult thrips, immerse them in the pesticide solution for 5-10 seconds, then remove them. Use filter paper to absorb excess pesticide from the leaves and thrips. Use a fine brush to transfer the thrips to fresh, non-toxic young eggplant leaves. Place the mixture in a culture jar, cover it, and ensure good ventilation. Use small, damp cotton balls to maintain humidity. Place the culture jar containing the treated thrips at 25±1°C. o C. The animals were raised and observed in a constant temperature incubator with a relative humidity of 60%-80%. Each treatment was replicated four times. A blank control was set up, containing no drugs (but containing organic solvents and emulsifiers).

[0255] After 24 hours of treatment, investigate the mortality of the test insects. The criterion for determining mortality is no obvious crawling reaction when lightly touched with a soft, fine brush. Record the total number of insects and the number of dead insects. Calculate the mortality rate and control efficacy.

[0256] During the experiment, the preparation of the drug solution must be accurate to minimize errors; the operation should be skillful and quick, and the experimental operation procedures should be followed to ensure the accuracy of the experiment. If the mortality rate of the blank control experiment exceeds 20%, the experiment must be repeated.

[0257] Calculation method:

[0258] Mortality rate (%) = (Number of dead test insects / Number of test insects before drug administration) × 100

[0259] Efficacy % = ((mortality rate in treatment group - mortality rate in control group) / (100 - mortality rate in control group)) × 100

[0260] Table 2. Tests on thrips using the combination of compound I and compound II.

[0261]

[0262] Experiment 3: Tomato Whitefly Experiment

[0263] Drug solution preparation: Prepare a stock solution of compound I and compound II using acetone, and then dilute it with 0.1% Tween-80 aqueous solution to the required concentration.

[0264] Before the experiment, whiteflies were inoculated onto insect-free potted tomato seedlings grown in an indoor greenhouse with insect-proof netting. After the whiteflies laid eggs, hatched, and developed into 2nd-3rd instar nymphs of the F1 generation, tomato leaves were cut off, and non-experimental insect stages such as eggs were removed under a microscope. Each leaf contained 30-50 experimental nymphs for testing.

[0265] Whiteflies and tomato leaves were soaked together in the prepared pesticide solution for 5 seconds, then removed, excess solution was blotted with absorbent paper, and the mixture was placed in a plastic beaker with a diameter of 6 cm and a height of 10 cm. After the experiment, the mixture was transferred to a container at 25±1°C. o C. They were raised in a constant temperature incubator with a relative humidity of 60%-80%. Each treatment was replicated four times. A blank control was set up, containing no drugs (but containing organic solvents and emulsifiers).

[0266] 72 hours after treatment, examine the mortality of the test insects under a microscope. The criteria for judging mortality are shriveled bodies and a yellowish-brown color. If the mortality rate of the control group is greater than 20%, the experiment should be repeated. Record the total number of insects and the number of dead insects. Calculate the mortality rate and the control effect.

[0267] During the experiment, the preparation of the drug solution must be accurate to minimize errors; the operation should be skillful and quick, and the experimental operation procedures should be followed to ensure the accuracy of the experiment. If the mortality rate of the blank control experiment exceeds 20%, the experiment must be repeated.

[0268] Calculation method:

[0269] Mortality rate (%) = (Number of dead test insects / Number of test insects before drug administration) × 100

[0270] Efficacy % = (Morality rate in treatment group - Mortality rate in control group) / (100 - Mortality rate in control group) × 100

[0271] Table 3. Tests of the combination of compound I and compound II on tomato whiteflies.

[0272]

[0273] Experiment 4: Cotton Red Spider Mite Experiment

[0274] Drug solution preparation: Prepare a stock solution of compound I and compound II using acetone, and then dilute it with 0.1% Tween-80 aqueous solution to the required concentration.

[0275] The red spider mite was tested in the laboratory using cotton seedlings through continuous generations of rearing. Adult mites were selected for testing. Female adult mites with consistent physiological states and reared indoors were chosen. Double-sided tape was cut into 2cm lengths and attached to one end of a glass slide. Healthy female adult mites were then selected, and their backs were attached to the tape (avoiding the legs, antennae, and mouthparts). 30 mites were placed on each slide and placed in a container lined with a damp sponge. The container was then covered and incubated at 25±1°C. o Under condition C, microscopic examination was performed 2 hours later to remove dead and injured individuals, and to replenish each piece with 30 individuals.

[0276] The spider mite slide immersion method (NY / T 1154.12-2008) was used. Slides contaminated with spider mites were immersed in the pesticide solution, gently agitated for 5 seconds, then removed. Excess pesticide was absorbed with absorbent paper, and the slides were placed on a white dish lined with a damp sponge. The dish was covered with translucent plastic wrap, and small holes were punctured with an insect needle to ensure ventilation. Each treatment was repeated four times. A blank control was provided, containing no pesticide (but containing organic solvents and emulsifiers).

[0277] Place the white disk containing the red spider treatment material at a temperature of 25±1℃. oC. They were raised and observed in a constant temperature incubator with a relative humidity of 60%-80%.

[0278] After 48 hours of treatment, mites were considered dead if they showed no obvious reaction when their legs, antennae, or palps were gently touched with a soft brush under a stereoscope. The number of dead mites was recorded.

[0279] During the experiment, the preparation of the drug solution must be accurate to minimize errors; the operation should be skillful and quick, and the experimental operation procedures should be followed to ensure the accuracy of the experiment. If the mortality rate of the blank control experiment exceeds 20%, the experiment must be repeated.

[0280] Calculation method:

[0281] Mortality rate (%) = Number of dead mites / Number of test mites before drug administration × 100

[0282] Prevention and control efficacy % = (mortality rate of treatment group - mortality rate of control group) / (100 - mortality rate of control group) × 100

[0283] Table 4. Tests of the combination of compound I and compound II on the carmine spider mite.

[0284]

[0285] The experimental results in Tables 1-4 show that the combination of compound I and compound II achieved an unexpected synergistic effect in controlling diamondback moth, thrips, whitefly, and spider mite.

Claims

1. A use of an insecticide composition for preventing or controlling Tetranychus cinnabarinus and Thrips tabaci, characterized in that: The insecticide composition contains active ingredients Compound I and Compound II, Compound I The compound II is selected from chlorfenapyr, and the weight ratio of the compound I to the compound II is 10:1-1:

50.

2. The use according to claim 1, characterized in that The weight ratio of the compound I to the compound II is 5:1-1:

25.

3. The use according to claim 1, characterized in that The insecticide composition further comprises a surfactant and / or a filler.

4. The use according to claim 1, characterized in that The weight of the compound I and the compound II together accounts for 1% to 90% by weight of the insecticide composition.

5. The use according to claim 1, characterized in that: The weight of the compound I and the compound II together accounts for 5% to 80% by weight of the insecticide composition.

6. The use according to claim 1, characterized in that: The insecticide composition has the following dosage forms: emulsifiable concentrate, water suspension, oil suspension, seed treatment dry powder, seed treatment suspension, water dispersible granules, wettable powder, suspoemulsion, water emulsion, microcapsule suspension, dry suspension, ultra-low volume liquid, microgranules and microemulsion.

7. The use according to claim 1, characterized in that The insecticidal composition according to claim 1 is applied to target useful plants, target pests or their environment, or propagation materials of target useful plants.

8. The use according to claim 1, characterized in that The insecticidal composition according to claim 1 is applied to seeds, target useful plants or soil where plants grow or soil suitable for plant growth.

9. The use according to claim 1, characterized in that The insecticide composition of claim 1 is applied to the soil before, after or before or after germination of seeds and / or directly applied to the soil in contact with plant roots or soil suitable for plant growth.

10. The use according to claim 1, characterized in that The seeds are contacted with an insecticidal effective amount of the insecticidal composition according to claim 1 before sowing and / or after germination.

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