Medicaments for the prevention and treatment of hyperpigmentation

Abstract

Olfactory receptor agonists are presented that exhibit (i) a molecular weight of about 50 to about 300 Daltons and (ii) a relative evaporation rate to butyl acetate of about 3 to about 15 for use as a medicament for the prevention and / or treatment of hyperpigmentation of human skin.

Description

Invention Field

[0001] This invention relates to the field of pharmaceutical compositions, and specifically to pharmaceutical compositions for the prevention and / or treatment of hyperpigmentation of human skin. Background of the Invention

[0003] Tyrosinase is a copper-containing enzyme that catalyzes the oxidation of phenols, such as tyrosine. It is widely distributed in almost all organisms. In animals and humans, tyrosinase (along with Tyrp1 and Dct enzymes) participates in the synthesis of melanin on the melanocyte membrane, and is therefore essential for protection against ultraviolet radiation. In some organisms with albinism, this enzyme is altered or completely absent.

[0004] Tyrosinase production increases with increasing UVB radiation. Then, the following chemical reactions occur more intensely on the melanocyte membrane.

[0005]

[0006] In the first step, tyrosine is oxidized to L-DOPA:

[0007]

[0008] L-DOPA is further oxidized to dopaquinone, which is independently oxidized to dopachrome in two steps. From here, a two-step reaction pathway for melanin production becomes possible with the help of TYRP1 and DCT enzymes. However, tyrosinase can also produce melanin from dopachrome itself:

[0009]

[0010] Dopachrome undergoes decarboxylation and rearrangement to yield 5,6-dihydroxy-indole (DHI):

[0011]

[0012] Subsequently, DHI is oxidized to indole-5,6-quinone, which eventually polymerizes into melanin with the help of oxygen.

[0013] While sufficiently high tyrosinase activity is necessary for tanning human skin by producing melanin to protect it from the harmful effects of excessive UV radiation, overproduction can lead to undesirable results, particularly the formation of brown spots on the skin known as hyperpigmentation, a skin pathology condition that can be caused by factors such as sun damage, inflammation, or other skin lesions—including lesions associated with acne vulgaris ("Hyperpigmentation". Dermatalogic Disease Database. American Osteopathic College of Dermatology. Retrieved 2006-03-08.). Hyperpigmentation is also often associated with other conditions, such as insulin resistance.

[0014] Beyond this clinical situation, there is also a cosmetic market, particularly in Asia, that restricts tyrosinase activity with the aim of giving the skin a particularly bright appearance. In this context, skin whitening agents have been discussed.

[0015] Related existing technologies

[0016] Numerous examples of tyrosinase inhibitors are known in the prior art, as shown in the following examples:

[0017] Kojic acid and its derivatives, for example, are disclosed in US 4,278,656A (SANSHO), US 5,523,421 A (PACIFIC CO), WO 2000 056270A1 (PFIZER), WO 2002 053562A1 (AMOREPACIFIC) or WO 2019194769A1 (AYSE);

[0018] Resorcinol derivatives, such as phenylethyl resorcinol or butyl resorcinol, are disclosed, for example, in FR2993775A1 (SISLEY) or US2002 114770AA (WARNER LAMBERT).

[0019] Superoxide dismutase, for example, disclosed in JP 59 065022A (TOYO);

[0020] Benzoamidazole derivatives, for example, disclosed in US2002 044914AA (MEDIQUEST);

[0021] Hydantoin derivatives, for example, disclosed in DE 10342839 A2 (SYMRISE);

[0022] Sphingosine, for example, is disclosed in WO 2004 045573A1 (DOOSAN):

[0023] Protocatechuic aldehydes, for example, are disclosed in WO 2002 045680A1 (GENOMINE);

[0024] N-hydroxysuccinimide, for example, is disclosed in JP 2006 248913A2 (KOSE);

[0025] Salicylic acid, for example, disclosed in US 5,723,109 A (L'OREAL);

[0026] Extracts derived from plants belonging to, for example, the following families:

[0027] Aronia (JP 2013 139399A2, POLA);

[0028] ·Desmodium (WO 2019 009645A1, KOREA RES).

[0029] ·Diterocar Desmodium pus(WO 2017 086692A1,GYEONGGI);

[0030] ·Ecklonia (WO 2010 098533A2, UNIV PUKYONG);

[0031] • Licorice (Glyzyrrhiza) (JP 01 149706A2, MARUZEN);

[0032] Grape seed (JP 2000 159681A2, HAETAE);

[0033] • Labiatae (FR 2895678 A1, L'OREAL);

[0034] Magnolia (US2011 318288AA, COREANA);

[0035] • Polyporus (JP 03 109319A2, NARISU);

[0036] • Prunus (JP 03 127714A2, KOBAYASHI);

[0037] Invention Theme

[0038] Therefore, the object of this invention is to identify compounds capable of reducing melanin production by inhibiting or limiting the activity of tyrosinase. In other words, there is a need, on the one hand, for medicines that can be used to prevent or treat hyperpigmentation of human skin, and on the other hand, for skin whitening agents for non-therapeutic cosmetic applications.

[0039] Another task is to find molecules that are already on the market and are known for their toxicological safety. Summary of the Invention

[0040] The first object of the present invention relates to an olfactory receptor agonist having a molecular weight of about 50 to about 300 Daltons, preferably about 75 to about 250 Daltons, and an evaporation rate relative to butyl acetate of about 3 to about 15, preferably about 5 to about 10, for use as a medicament for preventing or treating hyperpigmentation by inhibiting tyrosinase activity.

[0041] Surprisingly, a small, volatile molecule found in human skin that activates olfactory receptors solved the aforementioned problem. In tests on B16 melanoma cells, tyrosinase activity was reduced by up to 45%.

[0042] Another advantage is that these molecules are already known as cosmetic additives, especially as fragrances. They are readily available and can be formulated into cosmetic or pharmaceutical preparations without any problems.

[0043] olfactory receptors

[0044] Olfactory receptors (ORs), also known as odorant receptors, are expressed in the cell membranes of olfactory receptor neurons and are responsible for detecting odor molecules carried by air entering the nasal cavity. Activation of olfactory receptors triggers nerve impulses that transmit odor information to the brain. These receptors are members of the rhodopsin-like family of G protein-coupled receptors (GPCRs). Human olfactory receptors constitute a multigene family of approximately 800 genes. Specifically, the human nose has approximately 400 odorant receptors, capable of detecting at least one trillion different odors.

[0045] Olfactory receptors do not bind to specific ligands; instead, they exhibit affinity for a range of odor molecules. In fact, a single odor molecule can bind to many olfactory receptors with varying affinities, depending on the molecule's physiochemical properties, such as its size. Once an odorant binds to an odor receptor, the receptor undergoes a structural change, binding to and activating olfactory G proteins within the olfactory receptor neuron. G proteins (G...) olf and / or G sIn turn, it activates the lyase adenylate cyclase, which converts ATP into cyclic AMP (cAMP). cAMP opens cyclic nucleotide-gated ion channels, allowing calcium and sodium ions to enter the cell, depolarizing olfactory receptor neurons, and initiating action potentials that transmit information to the brain.

[0046] A naming system has been designed for the olfactory receptor family and forms the basis of the official Human Genome Project (HUGO) notation for the genes encoding these receptors. The names of each member of the olfactory receptor family follow the format "ORnXm", where:

[0047] OR stands for root name (olfactory receptor superfamily).

[0048] • n = an integer representing a family (e.g., 1-56) whose members share more than 40% sequence identity.

[0049] • X = a single letter (A, B, C, ...) representing a subfamily (>60% sequence identity), and

[0050] ·m = an integer representing a single family member (subtype).

[0051] For example, OR1A1 is the first subtype of subfamily A of the olfactory receptor family. An overview of olfactory receptors can be found in Gaillard I, Rouquier S, Giorgi:D "Olfactory receptors". Cellular and Molecular Life Sciences. 61(4):456–69 (2004).

[0052] The evaporation rate is the rate at which the material evaporates (evaporates from liquid to vapor) compared to the evaporation rate of butyl acetate—which is set to 1. This quantity is a ratio and therefore dimensionless.

[0053] olfactory receptor agonists

[0054] Suitable agonists according to the present invention are selected from the group comprising:

[0055] ·(-)CBG;

[0056] • C12 aldehyde;

[0057] ·Allyl phenoxyacetate;

[0058] · Benzaldehyde;

[0059] ·Benzylacetone;

[0060] Claritone (2,4,4,7-tetramethyloct-6-en-3-one, CAS-No. 74338-72-0);

[0061] • Cyclogalbanate;

[0062] Cyclohexylmagnol;

[0063] · 8-Cyclohexadecene-1-one (Globanone) ((cis / trans)cyclohexadecene-8-en-1-one, CAS-No. 3100-36-5);

[0064] • 3,3,5-Trimethylacetic acid cyclohexyl ester (Mintonat) (=High-menthol ester acetate CAS-No. 67859-96-5);

[0065] ·Phenylacetal;

[0066] ·4-(3-methylbutyl)cyclohexyl-1-ol (CAS-No. 830322-14-0);

[0067] • Tagetes oil;

[0068] and its mixtures.

[0069] The agonist can be administered at a concentration of 0.1 to 100 μg / ml, preferably 0.5 to 10 μg / ml.

[0070] Cosmetic and pharmaceutical compositions

[0071] Another object of the present invention relates to a cosmetic or pharmaceutical composition comprising an agonist as defined above, preferably in an amount of 0.0001 to about 1% by weight, more preferably about 0.001 to about 0.1% by weight.

[0072] The composition may be a lotion, cream, emulsion, ointment, or any other form applied topically to the skin.

[0073] carrier or solvent

[0074] In a preferred embodiment, the composition may comprise a cosmetic or pharmaceutically acceptable carrier or solvent, such as water, ethanol, isopropanol, butanol, glycerin, ethylene glycol, propylene glycol, and diethylene glycol, or mixtures thereof. The carrier may be present in an amount of 99% by weight, preferably 99.9% by weight or more.

[0075] Biologics, antioxidants and other skin whitening agents

[0076] In another preferred embodiment, the composition may comprise at least one biological agent or antioxidant. Bioactive substances include, for example, tocopherol, tocopheryl acetate, tocopheryl palmitate, ascorbic acid, (deoxy)ribonucleic acid and its fragmented products, β-glucan, retinol, bisabolol, allantoin, phytanetriol, panthenol, AHA acid, amino acids, ceramides, pseudoceramides, essential oils, plant extracts such as plum extracts, bambaranus extracts, and vitamin complexes.

[0077] Antioxidants block the photochemical reaction chain triggered when ultraviolet light penetrates the skin. Typical examples include amino acids (such as glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (such as uric acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (such as anserine), carotenoids, carotenoids (such as α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (such as dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (such as thioredoxin, glutathione, cysteine, cystine, cystamine and its glycosyl groups, N-acetyl groups). Methyl, ethyl, propyl, pentyl, butyl, lauryl, palmitoyl, oleylenyl, α-linoleyl, cholesterol, and their glycerides) and their salts, dilaurate thiodipropionate, dioctadecyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides, and salts), and sulfonylimine compounds at very low resistance levels (e.g., pmol to mol / kg) (e.g., sulfonyl butyrate, sulfonyl homocysteine, sulfonyl butyrate, pentyl, hexa-, and hepta-thionine sulfonylimine), and (metal) chelating agents (e.g., hydroxyaliphatic acid). Acids, palmitic acid, phytic acid, lactoferrin), hydroxy acids (e.g., citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g., linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and panthenol and their derivatives, vitamin C and its derivatives (e.g., ascorbate palmitate, ascorbate magnesium phosphate, ascorbate acetate), tocopherol and its derivatives (e.g., vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), and benzene from benzoin resin. Formate, rutin and its derivatives, saccharorutin, ferulic acid, furfuryl sorbitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiacol, nordihydroguaiacol, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, zinc and its derivatives (e.g., ZnO, ZnSO4), selenium and its derivatives (e.g., methionine selenium), stilbenes and their derivatives (e.g., stilbene oxide, trans-stilbene oxide), and derivatives of these active compounds suitable for the purposes of this invention (salts, esters, ethers, sugars, etc.).

[0078] The agonist according to the invention can also be combined with other skin whitening agents and / or tyrosinase inhibitors (different from the agonist), such as kojic acid and resorcinol derivatives such as phenylethyl resorcinol or butyl resorcinol, preferably in a weight ratio of about 10:90 to about 90:10, more preferably about 25:75 to about 75:25, and most preferably about 40:60 to about 60:40. Such mixtures can also be provided in packaged form.

[0079] Other additives for cosmetic and pharmaceutical compositions

[0080] When the agonist according to the invention is incorporated into or delivered to human skin through a cosmetic or pharmaceutical composition, it may contain other additives commonly used in skin care applications, such as:

[0081] surfactants

[0082] Preferred auxiliaries and additives are anionic and / or amphoteric or zwitterionic surfactants. Nonionic and cationic surfactants may also be present in the composition. Suitable examples are mentioned in the paragraphs concerning emulsifiers.

[0083] Typical examples of anionic and amphoteric surfactants include: amygdalinamide propylamine oxide, amygdalinamide propyl betaine, aminopropyl lauryl glutamine, C12-15 alkanol sulfate ammonium, C12-16 alkanol sulfate ammonium, octanol polyether sulfate ammonium, glyceryl monocolate sulfate ammonium, cocoyl alcohol sulfate ammonium, cocoyl hydroxyethanesulfonate ammonium, cocoyl sarcosine ammonium, C12-15 alkanol polyether sulfate ammonium, C9-10 perfluoroalkyl sulfonate ammonium, dinonyl sulfosuccinate ammonium, dodecylbenzene sulfonate ammonium, isostearate ammonium, lauryl ether-6 carboxylate ammonium, lauryl ether-8 carboxylate ammonium, lauryl ether-5 sulfate ammonium, lauryl ether-7 sulfate ammonium, lauryl ether-9... Ammonium sulfate, ammonium lauryl ether-12 sulfate, ammonium lauroyl sarcosine, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myristyl ether sulfate, ammonium myristyl sulfate, ammonium nonylphenol polyether-4 sulfate, ammonium nonylphenol polyether-30 sulfate, ammonium oleate, ammonium palm kernel oil sulfate, ammonium stearate, ammonium tallowate, ammonium isostearyl hydrolyzed collagen AMPD salt, rosin (acyl) hydrolyzed collagen AMPD salt, isostearyl hydrolyzed collagen AMP salt, isostearyl hydrolyzed keratin AMP salt, isostearyl hydrolyzed soybean protein AMP salt, isostearyl hydrolyzed wheat protein AMP salt, apricot oleamidopropyl betaine, arachidic acid, hexyldecyl phosphate arginine salt, avocado oleamidopropyl betaine, avocado oil glyceryl polyether -8 esters, babassu seed oil acid, babassu oleamidopropylamine oxide, babassu oleamidopropyl betaine, beeswax acid, behenamidopropyl betaine, behenamine oxide, behenyl alcohol polyether-25, behenyl alcohol polyether-30, behenic acid, behenyl betaine, bis-butyldimethylsiloxane polyglycerol-3, butylphenol polyether-5 carboxylic acid, butylphenol polyether-19 carboxylic acid, butyl dimethyl (hydroxypropyl butyl glucoside) ammonium chloride, butyl dimethyl (hydroxypropyl lauryl glucoside) ammonium chloride, butyl glucoside, butyl glucoside decanoate, butyl glucoside hydroxypropyl trimethyl ammonium chloride, butyl octanoic acid, C18-36 acid, C20-40 acid, C30-50 acid, C16-22 acid amide MEA, calcium dodecylbenzenesulfonate. Calcium lauroyl taurate, C9-16 alkyl / cycloalkanes, C10-14 alkylbenzene sulfonic acid, C12-14 alkyl di(aminoethyl)glycine HCl, C9-15 alcohol phosphate esters, Candida albicans / glucose / rapeseed oil methyl ester fermentation products, low erucic acid rapeseed oil amamidopropyl betaine, decanoic acid, hexanoic acid, hexanoyl ethyl glucoside, octanoyl / decanoyl aminopropyl betaine, octanoyl polyether-4 carboxylic acid, octanoyl polyether-6 carboxylic acid, octanoyl polyether-9 carboxylic acid, octanoic acid, octanoyl collagen amino acids, octanoyl glycine, octanoyl hydrolyzed collagen, octanoyl hydrolyzed keratin, octanoyl keratin amino acids, octanoyl silk amino acids, octyl / decyl glucoside, octyl / decyl wheat bran / straw glycosides, octyl glucoside, octyl glyceryl ether, octylpyrrolidone, carnitine.Cetearyl alcohol polyether-20, cetearyl alcohol polyether-23, cetearyl alcohol polyether-24, cetearyl alcohol polyether-25, cetearyl alcohol polyether-27, cetearyl alcohol polyether-28, cetearyl alcohol polyether-29, cetearyl alcohol polyether-30, cetearyl alcohol polyether-33, cetearyl alcohol polyether-34, cetearyl alcohol polyether-40, cetearyl alcohol polyether-50, cetearyl alcohol polyether-55, cetearyl alcohol polyether-60, cetearyl alcohol polyether-80, cetearyl alcohol polyether-100, cetearyl alcohol polyether-25 carboxylic acid, cetearyl alcohol polyether-2 phosphate ester, cetearyl alcohol Cetearyl ether-4 phosphate, cetearyl alcohol polyether-5 phosphate, dicetearyl alcohol polyether-10 phosphate, cetearyl alcohol polyether-20, cetearyl alcohol polyether-23, cetearyl alcohol polyether-24, cetearyl alcohol polyether-25, cetearyl alcohol polyether-30, cetearyl alcohol polyether-40, cetearyl alcohol polyether-45, cetearyl alcohol polyether-150, cetearyl alcohol polyether-8 phosphate, cetearyl alcohol polyether-10 phosphate, cetearyl alcohol polyether-20 phosphate, cetearyl oil alcohol polyether-22, cetearyl oil alcohol polyether-24, cetearyl oil alcohol polyether-25, cetearyl oil alcohol polyether-30, cetyl betaine, Chrysanthemum SINENSE flower extract, C12-14 hydroxyalkyl hydroxyethyl β-alanine, C12-14 hydroxyalkyl hydroxyethyl sarcosine, cocamidoethyl betaine, cocamidopropylamine oxide, cocamidopropyl betaine amide MEA chloride, cocamidopropyl betaine, cocamidopropyl hydroxysulfonate betaine, cocamidoamine oxide, cocoaminobutyric acid, cocoaminopropionic acid, cocoal alcohol polyether-7 carboxylic acid, cocoal alcohol polyether Ether-4 glucoside, cocoamphopropionic acid, cocobetaine amide amphoteric propionate, cocobetaine, cocodimethylammonium hydroxypropyl hydrolyzed rice protein, cocodimethylammonium hydroxypropyl hydrolyzed soybean protein, cocodimethylammonium hydroxypropyl hydrolyzed wheat protein, cocoglucoside, cocoglucoside hydroxypropyltrimethylammonium chloride, cocodihydroxysulfonate betaine, cocodimorpholine oxide, coconut oil acid, coconut oil glycerol polyether-8 Esters, cocamidopropyl betaine, cocoyl-sulfobetaine, (coconut oil / sunflower oil) amamidopropyl betaine, cocoylcholine methyl sulfate, cocoyl glutamate, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, cocoyl hydrolyzed oat protein, cocoyl hydrolyzed rice protein, cocoyl hydrolyzed silk, cocoyl hydrolyzed soybean protein, cocoyl hydrolyzed wheat protein, cocoyl sarcosine, corn oleic acid, cotton Cottonseed oil acid, cottonseed oil glycerol polyether-8 esters, C10-16 alkanol polyether-1, C10-16 alkanol polyether-2, C11-13 alkanol polyether-6, C11-13 alkanol polyether-9, C11-13 alkanol polyether-10, C11-15 alkanol polyether-30, C11-15 alkanol polyether-40, C12-13 alkanol polyether-1, C12-13 alkanol polyether-23C12-14 Alkyl Polyether-5, C12-14 Alkyl Polyether-9, C13-15 Alkyl Polyether-21, C14-15 Alkyl Polyether-8, C20-22 Alkyl Polyether-30, C20-40 Alkyl Polyether-40, C20-40 Alkyl Polyether-95, C22-24 Alkyl Polyether-33, C30-50 Alkyl Polyether-40, C9-11 Alkyl Polyether-6 Carboxylic Acid, C9-11 Alkyl Polyether-8 Carboxylic Acid, C11-15 Alkyl Polyether-7 Carboxylic acids, C12-13 alkanol polyether-5 carboxylic acid, C12-13 alkanol polyether-7 carboxylic acid, C12-13 alkanol polyether-8 carboxylic acid, C12-13 alkanol polyether-12 carboxylic acid, C12-15 alkanol polyether-7 carboxylic acid, C12-15 alkanol polyether-8 carboxylic acid, C12-15 alkanol polyether-12 carboxylic acid, C14-15 alkanol polyether-8 carboxylic acid, C6-10 alkanol polyether-4 phosphate, C12-13 alkanol polyether-2 phosphate, C12-13 alkanol C12-15 Alkyl Polyether-6 Phosphate, C12-15 Alkyl Polyether-8 Phosphate, C12-15 Alkyl Polyether-10 Phosphate, C12-16 Alkyl Polyether-6 Phosphate, C4-18 Perfluoroalkyl Ethyl Mercaptopropyl Trimethylammonium Chloride, Cocoa Fatty Acid Aminopropyl Betaine, C12-13 Alcohol Sulfate DEA Salt, C12-15 Alcohol Sulfate DEA Salt, Cetearyl Alcohol Polyether-2 Phosphate DEA Salt, Cetyl Alcohol Sulfate DEA Salt, Cocoyl Amphoteric dipropionic acid DEA salt, C12-13 alkanol polyether-3 sulfate DEA salt, cyclocarboxypropyl oleic acid DEA salt, dodecylbenzene sulfonic acid DEA salt, isostearic acid DEA salt, lauryl ether sulfate DEA salt, lauryl sulfate DEA salt, linoleic acid DEA salt, methyl myristate sulfonic acid DEA salt, myristyl ether sulfate DEA salt, myristic acid DEA salt, myristyl sulfate DEA salt, oleyl alcohol polyether-5 phosphate DEA salt, oleyl alcohol polyether-20 phosphate DEA salt, DEA PG-Oleate, Decanol Polyether-7 Carboxylic Acid, Decanol Polyether-7 Glucoside, Decanol Polyether-9 Phosphate, Decylamine Oxide, Decyl Betaine, Undecyl Glucoside, Decyl Tetradecyl Polyether-30, Decyl Tetradecylamine Oxide, Laurylamide-MEA Sulfosuccinate Diammonium, Lauryl Sulfosuccinate Diammonium, Oleamide-based PEG-2 Sulfosuccinate Diammonium, Dibutoxymethane, DiC12-15 Alkyl Alkyl Polyether-2 Phosphate DiC12-15 alkanol polyether-4 phosphate, DiC12-15 alkanol polyether-6 phosphate, DiC12-15 alkanol polyether-8 phosphate, DiC12-15 alkanol polyether-10 phosphate, Di-dodecyl butane tetracarboxylate, Lauryl ether sulfate diethylamine salt, Sodium diethylhexyl sulfosuccinate, Di(hydroxyethyl)C8-10 alkoxypropylamine oxide, Di(hydroxyethyl)C9-11 alkoxypropylamine oxideDi(hydroxyethyl)C12-15 alkoxypropylamine oxide, Di(hydroxyethyl)cocoamine oxide, Di(hydroxyethyl)laurylamine oxide, Di(hydroxyethyl)stearylamine oxide, Di(hydroxyethyl)tallowylamine oxide, Polydimethylsiloxane PEG-7 phosphate, Polydimethylsiloxane PEG-10 phosphate, Polydimethylsiloxane PEG / PPG-7 / 4 phosphate, Polydimethylsiloxane PEG / PPG-12 / 4 phosphate, Polydimethylsiloxane / polyglycerol-3 crosspolymer, Polydimethylsiloxane propyl PG-betaine, Dimyroxymethyl phosphate, Dioleoamide ethylhydroxyethyl Methylammonium methyl sulfate, hydrogenated coconut oil acid DIPA salt, lanolin acid DIPA salt, myristic acid DIPA salt, dipotassium capryloyl glutamate, dipotassium lauryl sulfosuccinate, dipotassium undecenoyl glutamate, disodium babassulamamide MEA-sulfosuccinate, disodium decanoyl amphoteric acid diacetate, disodium decanoyl amphoteric acid dipropionate, disodium capryloyl amphoteric acid diacetate, disodium capryloyl amphoteric acid dipropionate, disodium capryloyl glutamate, disodium cetearyl sulfosuccinate, disodium cetyl phenyl ether disulfonic acid, disodium cetyl sulfosuccinate, disodium cocamidoyl MEA-sulfosuccinate, disodium cocamidoyl MIPA Disodium PEG-4 sulfosuccinate, disodium cocamido-MIPA-sulfosuccinate, disodium cocamido-PEG-3 sulfosuccinate, disodium cocoyl alcohol polyether-3 sulfosuccinate, disodium cocoamphoyl carboxyethyl hydroxypropyl sulfonate, disodium cocoamphoyl diacetate, disodium cocoamphoyl dipropionate, disodium cocoyl glucoside sulfosuccinate, disodium cocoyl sulfosuccinate, disodium cocoyl... Butyl glucetol polyether-10 disodium sulfosuccinate, disodium cocoyl glutamate, C12-14 alkanol polyether-1 disodium sulfosuccinate, C12-14 alkanol polyether-2 disodium sulfosuccinate, C12-15 alkanol polyether sulfosuccinate, C12-14 secondary alkanol polyether-3 disodium sulfosuccinate, C12-14 secondary alkanol polyether-5 disodium sulfosuccinate, C12-1 Disodium 4-Second-Alkyl Ether-7 Sulfosuccinate, Disodium 9-Second-Alkyl Ether-9 Sulfosuccinate, Disodium 12-Second-Alkyl Ether-12 Sulfosuccinate, Disodium 5-Decanol Ether-5 Sulfosuccinate, Disodium 6-Decanol Ether-6 Sulfosuccinate, Disodium decylphenyl ether disulfonate, Disodium dihydroxyethyl sulfosuccinoyl undecenoate, Disodium dicocoyl ethylenediamine PEG-15 disulfate, Disodium hydrogenated cottonseed oil glyceride sulfosuccinate, disodium hydrogenated tallow glutamate, disodium hydroxydecyl sorbitan citrate, disodium isodecyl sulfosuccinate, disodium isostearamide MEA-sulfosuccinate, disodium isostearamide MIPA-MEA-sulfosuccinate, disodium isostearidine diacetate, disodium isostearidine dipropionate, disodium isostearyl sulfosuccinate, disodium lanolin alcohol ether-5 sulfosuccinate.Disodium lauramide MEA-sulfosuccinate, disodium lauramide MIPA ethylene glycol sulfosuccinate, disodium lauramide PEG-2 sulfosuccinate, disodium lauramide PEG-5 sulfosuccinate, disodium lauryl ether-5 carboxyamphodiacetate, disodium lauryl ether-7 citrate, disodium lauryl ether sulfosuccinate, disodium lauryl ether-6 sulfosuccinate, disodium lauryl ether-9 sulfosuccinate, disodium lauryl ether-12 sulfosuccinate, disodium lauryliminobis(hydroxypropyl)sulfonate, disodium lauryliminodiacetate, disodium lauryliminodiapropionate, disodium lauryliminodiapropionate tocopherol phosphate salt, disodium lauroylamphodiacetate, disodium lauroylamphodiapropionate. Disodium N-lauroyl aspartate, disodium lauroyl glutamate, disodium lauryl phenyl ether disulfonic acid, diammonium lauryl sulfosuccinate, disodium myristamide MEA-sulfosuccinate, disodium nonylphenol polyether-10 sulfosuccinate, disodium oleamide MEA sulfosuccinate, disodium oleamide MIPA sulfosuccinate, disodium oleamide PEG-2 sulfosuccinate, disodium oleoyl amphoteric dipropionate, disodium oleyl alcohol polyether-3 sulfosuccinate, disodium oleyl alcohol phosphate, disodium oleyl alcohol sulfosuccinate, disodium palmitamide PEG-2 sulfosuccinate, disodium palmitamide-based PEG-2 sulfosuccinate, disodium PEG-4 cocoamide MIPA-sulfosuccinate, disodium PEG-12 polydimethylsiloxane sulfonate Disodium sulfosuccinate, disodium PEG-8 palmitoleic acid glyceride sulfosuccinate, disodium PPG-2-isodecyl alcohol polyether-7 carboxyamphodiacetate, disodium ricinoleic acid amide MEA sulfosuccinate, disodium sitosterol polyether-14 sulfosuccinate, disodium soybean oil amphoteric diacetate, disodium stearamide MEA sulfosuccinate, disodium stearyl iminodipropionate, disodium stearyl amphoteric diacetate, disodium stearyl glutamate, disodium sulfosuccinate monoacyl stearamide, disodium stearyl alcohol sulfosuccinate, disodium 2-sulfolarate, disodium 2-sulfopalatate, disodium tallow oleamide MEA sulfosuccinate, disodium tallow amide MEA sulfosuccinate, disodium tallow amphoteric diacetate, disodium tallow iminodipropionate Sodium, disodium sulfosuccinate monoacyl tallowamine, disodium tridecyl sulfosuccinate, disodium undecenoamide MEA sulfosuccinate, disodium undecenoamide PEG-2 sulfosuccinate, disodium undecenoyl glutamate, disodium monowheat germ oleoyl MEA sulfosuccinate, disodium monowheat germ oleoyl PEG-2 sulfosuccinate, disodium wheat germ oleoyl amphoteric diacetate, cocamidoacetic acid di-TEA salt, oleamide PEG-2 sulfosuccinate di-TEA salt, palmitoyl aspartate di-TEA salt, sodium didecyl sulfosuccinate, dodecylbenzene sulfonic acid, erucamide propyl hydroxysulfobetaine, ethylhexyl alcohol polyether-3 carboxylic acid, ethyl PEG-15 cocoamine sulfate salt, octyl glyceryl ether, hexyl decanoic acidHydrogenated coconut oil acid, hydrogenated lanolin alcohol polyether-25, hydrogenated herring oil fatty acids, hydrogenated palm oil acid, hydrogenated palm kernel oil amine oxide, hydrogenated tallow acid, hydrogenated tallow amine oxide, hydrogenated tallow betaine, hydrogenated tallow alcohol polyether-25, hydrogenated tallow glutamic acid, hydrogenated Candida albicans extract, hydroxycetyl alcohol polyether-60, hydroxyethyl acetoxymethyl ammonium PG-polydimethylsiloxane, lauryl ether sulfate hydroxyethyl butylamine salt, hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl hydroxypropyl C12-15 alkoxypropylamine oxide, hydroxylauryl / hydroxymyristyl betaine, hydroxystearic acid, amide hydroxysuccinimide C10-40 ethylhexyl isoalkylate, amide hydroxysuccinimide C21-22 ethylhexyl isoalkylate, hydroxy Sulfobetine, IPDI / PEG-15 soybean oil amine oxide, IPDI / PEG-15 soybean oil amine ethanol sulfate methyl ester copolymer, IPDI / PEG-15 soybean oil glycine ester copolymer, lsoceteth-30, isolaurate-4 phosphate, isoglycerol-3 polydimethylsiloxane, isoglycerol-3 polydimethylsiloxane, isopropanolamine lanolinate, isopropanolamine dodecylbenzenesulfonate, isostearamide propylamine oxide, isostearamide propyl betaine, isostearamide propyl morpholine oxide, isostearyl alcohol polyether-8, isostearyl alcohol polyether-16, isostearyl alcohol polyether-22, isostearyl alcohol polyether-25, isostearyl alcohol polyether-50, isostearic acid, isostearyl hydrolyzed collagen, jojoba oil PEG-150 esters, jojoba wax PEG-80 esters, jojoba wax PEG-120 esters, lanolin alcohol polyether-20, lanolin alcohol polyether-25, lanolin alcohol polyether-40, lanolin alcohol polyether-50, lanolin alcohol polyether-60, lanolin alcohol polyether-75, lanolin acid, lauramide propylamine oxide, lauramide propyl betaine, lauramide propyl hydroxysulfonyl betaine, laurylamine oxide, lauryl aminopropionic acid, lauryl dimethyl hydroxypropyl decyl glucoside ammonium chloride, lauryl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, lauryl alcohol polyether-16, lauryl alcohol polyether-20, lauryl alcohol polyether-21, lauryl alcohol polyether-23, lauryl alcohol polyether-25, lauryl alcohol polyether-30, lauryl alcohol polyether-38 Lauryl ether-40, Lauryl ether-3 carboxylic acid, Lauryl ether-4 carboxylic acid, Lauryl ether-5 carboxylic acid, Lauryl ether-6 carboxylic acid, Lauryl ether-8 carboxylic acid, Lauryl ether-10 carboxylic acid, Lauryl ether-11 carboxylic acid, Lauryl ether-12 carboxylic acid, Lauryl ether-13 carboxylic acid, Lauryl ether-14 carboxylic acid, Lauryl ether-17 carboxylic acid, Lauryl ether-6 citrate, Lauryl ether-7 citrate, Lauryl ether-1 phosphate, Lauryl ether-2 phosphate, Lauryl ether-3 phosphate, Lauryl ether-4 phosphate, Lauryl ether-7 phosphate, Lauryl ether-8 phosphate, Lauryl ether-7 tartrate, Lauric acid, Lauryl imino dipropylene glycol, Lauryl imino dipropionic acid,Lauroyl amphoteric dipropionic acid, lauroyl β-aminopropionic acid, lauroyl collagen amino acid, lauroyl ethyltrimethylammonium methyl sulfate salt, lauroyl hydrolyzed collagen, lauroyl hydrolyzed elastin, lauroyl methyl glucamide, lauroyl sarcosine, lauroyl silk amino acid, lauryl betaine, lauroyl polydimethylsiloxane / polyglycerol-3 crosspolymer, lauroyl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, lauroyl glucoside, lauroyl glucoside hydroxypropyltrimethylammonium chloride, lauryl glycol hydroxypropyl ether, lauroyl hydroxysulfonyl betaine, lauroyl malic acid, lauroyl methyl glucosamine, (lauroyl / nutmeg)yl glycol hydroxypropyl ether, (lauroyl / nutmeg)yl wheat bran / straw glycosides, lauroyl polyglycerol-3 polydimethylsiloxane ethyl polydimethylsiloxane Methylsiloxane, laurylpyrrolidone, lauryl dimethyl sulfobetaine, linoleic acid, linolenic acid, linolenic acid, lysine cocoate, macadamia seed oil glyceryl polyether-8 esters, magnesium cocoyl alcohol polyether sulfate, magnesium cocoyl alcohol sulfate, magnesium isododecyl phenyl sulfonate, magnesium lauryl alcohol polyether-11 carboxylate, magnesium lauryl alcohol polyether sulfate, magnesium lauryl alcohol polyether-5 sulfate, magnesium lauryl alcohol polyether-8 sulfate, magnesium lauryl alcohol polyether-16 sulfate, magnesium lauryl alcohol polyether-3 sulfosuccinate, magnesium lauryl hydroxypropyl sulfonate, magnesium lauryl sulfate, magnesium methyl cocoyl taurate, magnesium myristyl alcohol polyether sulfate, magnesium oleyl alcohol polyether sulfate, magnesium cocoyl alcohol sulfate / TEA salt, Mannequin glacial mud, MEA salt of cocoyl oleate, magnesium lauryl alcohol polyether-6 carboxylate MEA salts, laurate sulfate MEA salts, PPG-6-laurate ether-7-carboxylic acid MEA salts, PPG-8-stearyl ether-7-carboxylic acid MEA salts, undecenoic acid MEA salts, meroxaprol 108, meroxaprol 174, meroxaprol 178, meroxaprol 254, meroxaprol 255, meroxaprol 258, meroxaprol 314, methoxyPEG-450 amide glutaryl succinamide, methoxyPEG-450 amide hydroxy succinimide succinate, methoxyPEG-450 maleimide, methylmorpholine oxide, milk amamidopropylamine oxide, milk amamidopropyl betaine, mink oleamidopropylamine oxide, mink oleamidopropyl betaine, C12 -15 Alkyl alcohol polyether sulfate MIPA salt, dodecylbenzene sulfonic acid MIPA salt, lauryl alcohol polyether sulfate MIPA salt, lauryl sulfate MIPA salt, mixed isopropanolamine lanolinate, mixed isopropanolamine lauryl sulfate, mixed isopropanolamine myristate, morpholine oleate, morpholine stearate, myristyl alcohol polyether-3 carboxylic acid, myristyl alcohol polyether-5 carboxylic acid, myristyl benzyl dimethyl ammonium chloride, myristamidopropylamine oxide, myristamidopropyl betaine, myristamidopropyl dimethylamine phosphate, myristamidopropyl hydroxysulfonyl betaine, myristamidopropyl PG-dimethyl ammonium chloride phosphate, myristamine oxide, myristaminopropionic acid, myristic acid, myristoyl ethyl trimethylammonium methyl sulfate saltMyristoyl glutamic acid, myristoyl hydrolyzed collagen, myristoyl sarcosine, myristyl betaine, myristyl / cetylamine oxide, myristoyl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, myristoyl glucoside, myristyl phosphate, nonylphenol polyether-20, nonylphenol polyether-23, nonylphenol polyether-25, nonylphenol polyether-30, nonylphenol polyether-35, nonylphenol polyether-40, nonylphenol polyether-44, nonylphenol polyether-50, nonylphenol polyether-100, nonylphenol polyether-120, nonylphenol polyether-5 carboxylic acid, nonylphenol polyether-8 carboxylic acid, nonylphenol polyether-10 carboxylic acid, nonylphenol polyether-3 phosphate, nonylphenol polyether-4 phosphate, nonylphenol polyether-6 phosphate, nonylphenol polyether-9 phosphate Ester, Nonylphenol Polyether-10 Phosphate, Dinonylphenol Polyether-30, Dinonylphenol Polyether-49, Dinonylphenol Polyether-100, Dinonylphenol Polyether-150, Dinonylphenol Polyether-7 Phosphate, Dinonylphenol Polyether-8 Phosphate, Dinonylphenol Polyether-9 Phosphate, Dinonylphenol Polyether-10 Phosphate, Dinonylphenol Polyether-11 Phosphate, Dinonylphenol Polyether-15 Phosphate, Dinonylphenol Polyether-24 Phosphate, Oat Oleamidopropyl Betaine, Octylphenol Polyether-16, Octylphenol Polyether-25, Octylphenol Polyether-30, Octylphenol Polyether-33, Octylphenol Polyether-40, Octylphenol Polyether-70, Octylphenol Polyether-20 Carboxylic Acid, Octyldodecyl Alcohol Polyether-20, Octyldodecyl Alcohol Polyether-25, Octyldodecyl Alcohol Polyether-30, oleamidopropylamine oxide, oleamidopropyl betaine, oleamidopropyl (hydroxysulfonyl)propyl dimethylammonium, oleylamine oxide, oleic acid, oleoyl hydrolyzed collagen, oleoyl sarcosine, oleyl alcohol polyether-20, oleyl alcohol polyether-23, oleyl alcohol polyether-24, oleyl alcohol polyether-25, oleyl alcohol polyether-30, oleyl alcohol polyether-35, oleyl alcohol polyether-40, oleyl alcohol polyether-44, oleyl alcohol polyether-50, oleyl alcohol polyether-3 carboxylic acid, oleyl alcohol polyether-6 carboxylic acid, oleyl alcohol polyether-10 carboxylic acid, oleoyl betaine, olive oil amide propylamine oxide, olive oil amide propyl betaine, olive oil acid, olive oil acyl hydrolyzed wheat protein, stearate of Ophiopogon japonicus extract, ozonated oleyl alcohol polyether-10, ozonated PEG-10 oleate, ozonated PEG-14 oleate, ozonated polysorbate 80, palmitoleic acid, palmitamide propyl betaine, palmitole alcohol polyether-2 phosphate, palmitamide propylamine oxide, palmitamide propyl betaine, palmitamine oxide, palmitic acid, palmitoyl collagen amino acids, palmitoyl glycine, palmitoyl hydrolyzed collagen, palmitoyl hydrolyzed milk protein, palmitoyl hydrolyzed wheat protein, palmitoyl keratin amino acids, palmitoyl oligopeptide, palmitoyl silk amino acids, palm kernel oil, palm kernel oil oleamide propyl betaine, peach kernel oil glycerol polyether-8 ester, arachidic acid, PEG-10 castor oil, PEG-40 castor oil, PEG-44 castor oil, PEG-50 castor oil, PEG-54 castor oil, PEG-55 castor oilPEG-60 castor oil, PEG-80 castor oil, PEG-100 castor oil, PEG-200 castor oil, PEG-11 cocamide, PEG-6 cocamide phosphate, PEG-4 cocoamine, PEG-8 cocoamine, PEG-12 cocoamine, PEG-150 disorbate, PEG-90 diisostearate, PEG-75 dilaurate, PEG-150 dilaurate, PEG-75 dioleate, PEG-150 dioleate, PEG-75 distearate, PEG-120 distearate, PEG-150 distearate, PEG-175 distearate, PEG-190 distearate, PEG-250 distearate, PEG- PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-30 glyceryl isostearate, PEG-40 glyceryl isostearate, PEG-50 glyceryl isostearate, PEG-60 glyceryl isostearate, PEG-90 glyceryl isostearate, PEG-23 glyceryl laurate, PEG-30 glyceryl laurate, PEG-25 glyceryl oleate, PEG-30 glyceryl oleate, PEG-30 glyceryl soybean oleate, PEG-25 glyceryl stearate, PEG-30 glyceryl stearate, PEG-40 glyceryl stearate, PEG-120 glyceryl stearate, PEG-200 glyceryl stearate, P EG-28 glyceryl shea butter, PEG-80 glyceryl shea butter, PEG-82 glyceryl shea butter, PEG-130 glyceryl shea butter, PEG-200 glyceryl shea butter, PEG-45 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-54 hydrogenated castor oil, PEG-55 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-200 hydrogenated castor oil, PEG-30 hydrogenated lanolin, PEG-70 hydrogenated lanolin, PEG-50 hydrogenated palmitamide, PEG-2 isostearate, PEG-3 isostearate, PEG-4 isostearate, PEG-6 isostearate PEG-8 isostearate, PEG-10 isostearate, PEG-12 isostearate, PEG-20 isostearate, PEG-30 isostearate, PEG-40 isostearate, PEG-26 jojoba acid, PEG-40 jojoba acid, PEG-15 jojoba alcohol, PEG-26 jojoba alcohol, PEG-40 jojoba alcohol, PEG-35 lanolin, PEG-40 lanolin, PEG-50 lanolin, PEG-55 lanolin, PEG-60 lanolin, PEG-70 lanolin, PEG-75 lanolin, PEG-85 lanolin, PEG-100 lanolin, PEG-150 lanolin, PEG-75 lanolin oil, PEG-2 laurylamide,PEG-3 laurylamine oxide, PEG-20 laurate, PEG-32 laurate, PEG-75 laurate, PEG-150 laurate, PEG-70 mango seed oil glycerides, PEG-20 mannitol laurate, PEG-8 methyl ether polydimethylsiloxane, PEG-120 methyl glucoside dioleate, PEG-80 methyl glucoside laurate, PEG-120 methyl glucoside trioleate, PEG-4 lignite, PEG-30 oleylamine, PEG-20 oleate, PEG-23 oleate, PEG-32 oleate, PEG-36 oleate, PEG-75 oleate, PEG-150 oleate, PEG-20 palmitate, PEG-15 0 polyglycerol-2 tristearate, PEG / PPG-28 / 21 acetate polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-3 / 17 copolymer, PEG / PPG-5 / 35 copolymer, PEG / PPG-8 / 55 copolymer, PEG / PPG-10 / 30 copolymer, PEG / PPG-10 / 65 copolymer, PEG / PPG-12 / 35 copolymer, PEG / PPG-16 / 17 copolymer, PEG / PPG-20 / 9 copolymer, PEG / PPG-20 / 20 copolymer, PEG / PPG-20 / 60 copolymer, PEG / PPG-20 / 65 copolymer, PEG / PPG PEG / PPG-22 / 25 copolymer, PEG / PPG-28 / 30 copolymer, PEG / PPG-30-35 copolymer, PEG / PPG-30 / 55 copolymer, PEG / PPG-35 / 40 copolymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copolymer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copolymer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copolymer, PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG-26-PPG-30 phosphate ester, PEG / PPG-4 / 2 propyl heptyl ether, PEG / PPG PEG-6 / 2-propylheptane ether, PEG-7 / PPG-2-propylheptane ether, PEG / PPG-8 / 2-propylheptane ether, PEG / PPG-10 / 2-propylheptane ether, PEG / PPG-14 / 2-propylheptane ether, PEG / PPG-40 / 2-propylheptane ether, PEG / PPG-10 / 2-ricinoleate, PEG / PPG-32 / 3-ricinoleate, PEG-55-propylene glycol oleate, PEG-25-propylene glycol stearate, PEG-75-propylene glycol stearate, PEG-120-propylene glycol stearate, PEG-5-rapeseed sterol, PEG-10-rapeseed sterol, PEG-40-ricinoleamide, PEG-75-sheath glycerides, PEG-75-saloyl bisacrylate glyceridesPEG-20 Sorbitan Cocoate, PEG-20 Sorbitan Isostearate, PEG-40 Sorbitan Lanolinate, PEG-75 Sorbitan Lanolinate, PEG-10 Sorbitan Laurate, PEG-40 Sorbitan Laurate, PEG-44 Sorbitan Laurate, PEG-75 Sorbitan Laurate, PEG-80 Sorbitan Laurate, PEG-20 Sorbitan Oleate, PEG-80 Sorbitan Palmitate, PEG-40 Sorbitan Stearate, PEG-60 Sorbitan Stearate, PEG-160 Sorbitan Triisostearate, PEG-40 Soy Sterol, PEG-2 Stearylamide Carboxylic acid, PEG-9 stearamide carboxylic acid, PEG-20 stearate, PEG-23 stearate, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate, PEG-35 stearate, PEG-36 stearate, PEG-40 stearate, PEG-45 stearate, PEG-50 stearate, PEG-55 stearate, PEG-75 stearate, PEG-90 stearate, PEG-100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 stearate phosphate, PEG-20 stearate, PEG-50 tallow amide, PEG-2 tallow amide DEA, PEG -20 Tallow Ester, PEG-66 Tristalpicillin, PEG-200 Tristalpicillin, PEG-60 Camellia Oil Ester Glycerides, Nonanoic Acid, Pentadecylphenol Polyether-200, Phenolic Polyether-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer 217, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 288, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamer 908, Poloxamer 1508, Polydimethylsiloxane PEG / PPG-24 / 19 Butyl Ether Silsesquioxane, Polydimethylsiloxane PPG-13 Butyl Ether Silsesquioxane, Polyglycerol-6 Decanoate, Polyglycerol-10 Dilaurate, Polyglycerol-20 Heptacaprate, Polyglycerol-20 Hexacaprate, Polyglycerol-2 Lauryl Ether, Polyglycerol-10 Lauryl Ether, Polyglyceryl-20 Octaisononanoate, Polyglycerol-6 Pentacaprate, Polyglycerol-10 Pentacaprate, Lauryl Polyglycerol-3 Polydimethylsiloxane, Polyglycerol-6 Tetracaprate, Polyglycerol-10 Tetracaprate, Polyglycerol-6 Tricaprate, Polyglycerol-10 Tricaprate, Polyquaternium-77, Polyquaternium-78, Polyquaternium-79, Polyquaternium-80, Polyquaternium-81, Polyquaternium-82Flower / leaf extracts of Pomaderris kumerahou, Poria cocos COCOS extract, abietic hydrolyzed collagen potassium, babassu oil potassium, behenate potassium, C9-15 phosphate potassium, C11-15 phosphate potassium, C12-13 phosphate potassium, C12-14 phosphate potassium, decanoate potassium, dipotassium octanoyl glutamate, octanoyl hydrolyzed rice protein potassium, ricinoleate potassium, cocoate potassium, cocoyl glutamate potassium, cocoyl glycine potassium, cocoyl hydrolyzed casein potassium, cocoyl hydrolyzed collagen potassium, cocoyl hydrolyzed corn protein potassium, cocoyl hydrolyzed keratin potassium, cocoyl hydrolyzed oat protein potassium, cocoyl hydrolyzed potato protein potassium, cocoyl hydrolyzed rice bran protein potassium, cocoyl hydrolyzed rice protein potassium, cocoyl hydrolyzed silk potassium, cocoyl hydrolyzed soybean protein potassium, cocoyl hydrolyzed... Potassium wheat protein, potassium cocoyl hydrolyzed yeast protein, potassium cocoyl PCA, potassium cocoyl sarcosinate, potassium cocoyl taurate, potassium corn oleate, potassium cyclocarboxypropyl oleate, potassium dihydroxyethyl cocoylamine oxide phosphate, potassium polydimethylsiloxane PEG-7 phosphate, potassium dodecylbenzene sulfonate, potassium hemp seed oil, potassium hydrogenated cocoate, potassium hydrogenated palm oil, potassium hydrogenated tallow, potassium hydroxystearate, potassium hydroxystearate, potassium lanolinate, potassium lauryl ether-3 carboxylate, potassium lauryl ether-4 carboxylate, potassium lauryl ether-5 carboxylate, potassium lauryl ether-6 carboxylate, potassium lauryl ether-10 carboxylate, potassium lauryl ether phosphate, potassium lauroyl collagen amino acid, potassium lauroyl glutamate, potassium lauroyl water Potassium oleate, potassium lauroyl hydrolyzed pea protein, potassium lauroyl hydrolyzed soybean protein, potassium lauroyl PCA, potassium lauroyl pea amino acids, potassium lauroyl sarcosine, potassium lauroyl silk amino acids, potassium lauroyl wheat amino acids, potassium lauryl phosphate, potassium lauryl sulfate, potassium linoleate, potassium metaphosphate, potassium methyl cocoyl taurate, potassium myristate, potassium myristoyl glutamate, potassium myristoyl hydrolyzed collagen, potassium octylphenol polyether-12 phosphate, potassium oleate, potassium oleyl hydrolyzed collagen, potassium olive oil, potassium olive oil yl hydrolyzed oat protein, potassium olive oil yl hydrolyzed wheat protein, potassium olive oil yl / lauroyl wheat amino acids, potassium olive oil yl PCA, potassium palmitate, potassium palmitate, potassium palmitate, potassium palmitate hydrolyzed corn protein, potassium palmitate, potassium palmitate Palmitoyl hydrolyzed oat protein potassium, palmitoyl hydrolyzed rice protein potassium, palmitoyl hydrolyzed sweet almond protein potassium, palmitoyl hydrolyzed wheat protein potassium, palm kernel oleate potassium, peanut oleate potassium, rapeseed oleate potassium, castor oil potassium, safflower oleate potassium, soybean oleate potassium, stearate potassium, stearoyl hydrolyzed collagen potassium, tallow potassium, potassium tallowate, taurine potassium, taurine potassium laurate, tridecyl alcohol polyether-3 carboxylate potassium, tridecyl alcohol polyether-4 carboxylate potassium, tridecyl alcohol polyether-7 carboxylate potassium, tridecyl alcohol polyether-15 carboxylate potassium, tridecyl alcohol polyether-19 carboxylate potassium, tridecyl alcohol polyether-6 phosphate potassium, tridecyl alcohol polyether-7 phosphate potassium, camellia oil potassium, undecenoic acid potassium, undecenoic acid hydrolyzed collagen potassium, undecenoic acid hydrolyzed rice protein potassiumPPG-30-Butanol Polyether-30, PPG-36-Butanol Polyether-36, PPG-38-Butanol Polyether-37, PPG-30-Octanol Polyether-4 Phosphate, PPG-10 Cetyl Ether Phosphate, PPG-2C9-11 Alcohol Polyether-8, PPG-1-Decanol Polyether-5, PPG-3-Decanol Polyether-2 Carboxylic Acid, PPG-30-Ethylhexanol Polyether-4 Phosphate, PPG-20-Glyceryl Polyether-30, PPG-2 Hydroxyethyl Coconut Oil / Isostearin Amides, PPG-2-isodecyl alcohol polyether-8, PPG-2-isodecyl alcohol polyether-10, PPG-2-isodecyl alcohol polyether-18, PPG-2-decyl alcohol polyether-25, PPG-4-decyl alcohol polyether-10, propyltrimethylammonium hydrolyzed collagen, quaternary ammonium salt-24, quaternary ammonium salt-52, quaternary ammonium salt-87, rapeseed oil acid, rice bran acid, rice bran oil glycerol polyether-8 esters, ricinoleic acid amyl betaine, ricinoleic acid, castor oil alcohol polyether-40, safflower oleic acid, Sapindus Oa-huensis fruit extract, Saponaria OFFICI-NALIS root powder, saponins, potassium soap, sodium / potassium soap, soap base, potassium soap base, sesame oil glyceryl polyether-8 esters, sesame oil amamidopropylamine oxide, sesame amamidopropyl betaine, shea butter amamidopropyl betaine, shea butter glyceryl polyether-8 esters, sodium arachidate, sodium Arga-nampohoacetate, Sodium aurum palm oil, Sodium avocado oil, Sodium babassu oleoyl amphoteric acid, Sodium babassu oleate, Sodium babassu oleate sulfate, Sodium behenate, Sodium diethylene glycol ricinoleic acid sulfosuccinate, Sodium dihydroxyethyl glycinate cocoyl glucoside cross-linked copolymer, Sodium dihydroxyethyl glycinate lauryl glucoside cross-linked copolymer, Sodium borage oleamidopropyl PG-dimethylammonium chloride phosphate, Sodium butylphenol polyether-12 sulfate, Sodium butyl glucoside hydroxypropyl phosphate, Sodium C13-17 alkyl sulfonate, Sodium C14-18 alkyl sulfonate, Sodium C12-15 alkyloxypropyliminodipropionate, Sodium C10-16 alcohol sulfate, Sodium C11-15 alkyl sulfate, Sodium C12-13 alkyl sulfate, Sodium C12-15 alkyl sulfate Sodium, C12-18 alkyl sulfate sodium, C16-20 alkyl sulfate sodium, C9-22 secondary alkyl sulfonate sodium, C14-17 secondary alkyl sulfonate sodium, sodium decanoate, sodium decanoamphoacetate, sodium decanoamphohydroxypropyl sulfonate, sodium decanoamphopropionate, sodium decanomethyl taurate, sodium octanoate, sodium octyl ether-2 carboxylate, sodium octyl ether-9 carboxylate, sodium octylamphoacetate, sodium octylamphohydroxypropyl sulfonate, sodium octylamphopropionate, disodium octyl glutamate, sodium octyl hydrolyzed wheat protein, sodium octyl PG-sulfonate, sodium octyl sulfonate, sodium ricinoleate, sodium cetearyl alcohol polyether-13 carboxylate, sodium cetearyl alcohol sulfate, sodium cetearyl alcohol polyether-13 carboxylate, sodium cetearyl alcohol sulfate, sodium cocamidopropyl PG-dimethylammonium chloride phosphate, sodium cocoaminopropionate.Sodium cocoyl ether sulfate, sodium cocoyl ether-30 sulfate, sodium cocoa butter amphoteric acid, sodium cocoa butter ester, sodium cocoa butter amphoteric acid, sodium cocoa butter amphoteric hydroxypropyl sulfonate, sodium cocoa butter amphoteric propionate, sodium cocoate, sodium cocoyl alcohol / babassu oil / adirabal alcohol sulfate, sodium cocoyl alcohol / babassu oil sulfate, sodium cocoyl glucoside hydroxypropyl phosphate, sodium cocoyl glucoside hydroxypropyl sulfonate, sodium cocoyl glucoside tartrate, sodium cocoyl alcohol glyceryl ether sulfonate, sodium cocoyl alcohol / hydrogenated tallow alcohol sulfate, sodium cocoyl iminodiacetic acid, sodium cocoyl monoglyceride sulfate, sodium cocoyl monoglyceride sulfonate, sodium cocoyl PG-dimethylammonium chloride phosphate, sodium cocoyl alcohol sulfate, sodium cocoyl alcohol sulfoacetate, coconut oil Sodium Cocoyl Amino Acid, Sodium Cocoyl Collagen Amino Acid, Disodium Cocoyl Glutamate, Sodium Cocoyl Glutamate, Sodium Cocoyl Glycinate, Sodium Cocoyl / Hydrogenated Tallow Glutamate, Sodium Cocoyl Hydrolyzed Collagen, Sodium Cocoyl Hydrolyzed Keratin, Sodium Cocoyl Hydrolyzed Rice Protein, Sodium Cocoyl Hydrolyzed Silk, Sodium Cocoyl Hydrolyzed Soy Protein, Sodium Cocoyl Hydrolyzed Sweet Almond Protein, Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium Cocoyl Ethylsulfonate, Sodium Cocoyl Methylaminopropionate, Sodium Cocoyl Oat Amino Acid, Sodium Sodium Cocoyl / Palmyl / Sunfloweroyl Glutamate, Sodium Cocoyl Proline, Sodium Cocoyl Sarcosinate, Sodium Cocoyl Taurate, Sodium Cocoyl Threonine, etc. Sodium oleoyl wheat amino acids, sodium C12-14 olefin sulfonate, sodium C14-16 olefin sulfonate, sodium C14-18 olefin sulfonate, sodium C16-18 olefin sulfonate, sodium corn oleoyl amphoteric propionate, sodium cottonseed oil oleoyl amphoteric acetate, sodium C13-15 alkanol polyether-8 butanol phosphate, sodium C9-11 alkanol polyether-6 carboxylate, sodium C11-15 alkanol polyether-7 carboxylate, sodium C12-13 alkanol polyether-5 carboxylate, sodium C12-13 alkanol polyether-8 carboxylate, sodium C12-13 alkanol polyether-12 carboxylate, sodium C12-15 alkanol polyether-6 carboxylate, sodium C12-15 alkanol polyether-7 carboxylate, sodium C12-15 alkanol polyether-8 carboxylate, sodium C14-15 alkanol polyether-8 carboxylate, sodium C12-14... Sodium secondary alkanol polyether-8 carboxylate, sodium C14-15 alkanol polyether-PG sulfonate, sodium C12-13 alkanol polyether-2 phosphate, sodium C13-15 alkanol polyether-8 phosphate, sodium C9-15 alkanol polyether-3 sulfate, sodium C10-15 alkanol polyether sulfate, sodium C10-16 alkanol polyether-2 sulfate, sodium C12-13 alkanol polyether sulfate, sodium C12-15 alkanol polyether sulfate, sodium C12-15 alkanol polyether-3 sulfate, sodium C13-15 alkanol polyether-3 sulfate, sodium C12-14 secondary alkanol polyether-3 sulfate, sodium C12-15 alkanol polyether-3 sulfonate, sodium C12-15 alkanol polyether-7 sulfonate, sodium C12-15 alkanol polyether-15 sulfonate, sodium decanol polyether-2 carboxylate, sodium decanol polyether sulfate.Sodium decylbenzenesulfonate, sodium decyl glucoside hydroxypropyl phosphate, sodium decyl glucoside hydroxypropyl sulfonate, sodium di(lauroyl ether-7) citrate, sodium di(lauroyl ether-10) phosphate, sodium dilinoleamide propyl PG-dimethylammonium chloride phosphate, sodium dimer linoleate, sodium di(oleyl ether-8) phosphate, sodium dodecylbenzenesulfonate, sodium ethyl 2-sulfolarate, sodium glycerol oleate phosphate, sodium grape seed oil amide propyl PG-dimethylammonium chloride phosphate, sodium grape seed oil acylamphoacetate, sodium grape seed oil, sodium hemp seed oil acylamphoacetate, sodium hexyl ether-4 carboxylate, hydrogenated sodium cocoate, hydrogenated sodium cocoyl methyl hydroxyethyl sulfonate, sodium hydrogenated palmitate, sodium hydrogenated tallow, sodium hydrogenated tallow glutamate. Sodium hydroxylauryl dimethylammonium ethyl phosphate, sodium hydroxypropyl palm kernel oil sulfonate, sodium hydroxypropyl phosphate decyl glucoside crosspolymer, sodium hydroxypropyl phosphate lauryl glucoside crosspolymer, sodium hydroxypropyl sulfonate cocoyl glucoside crosspolymer, sodium hydroxypropyl sulfonate decyl glucoside crosspolymer, sodium hydroxypropyl sulfonate lauryl glucoside crosspolymer, sodium hydroxystearate, sodium isostearate, sodium isostearate, sodium isostearyl alcohol polyether-6 carboxylate, sodium isostearyl alcohol polyether-11 carboxylate, sodium isostearoamphoacetate, sodium isostearoamphopropionate, sodium N-isostearoyl methyl taurate, sodium lanolin alcohol polyether sulfate, sodium lanolinate, sodium lardate, sodium lauramide diacetate, sodium lauryl aminopropionate, sodium lauryl acid, sodium lauryl alcohol polyether-3 carboxylate, sodium lauryl alcohol polyether Sodium lauryl ether-4 carboxylate, sodium lauryl ether-5 carboxylate, sodium lauryl ether-6 carboxylate, sodium lauryl ether-8 carboxylate, sodium lauryl ether-11 carboxylate, sodium lauryl ether-12 carboxylate, sodium lauryl ether-13 carboxylate, sodium lauryl ether-14 carboxylate, sodium lauryl ether-16 carboxylate, sodium lauryl ether-17 carboxylate, sodium lauryl ether sulfate, sodium lauryl ether-5 sulfate, sodium lauryl ether-7 sulfate, sodium lauryl ether-8 sulfate, sodium lauryl ether-12 sulfate, sodium lauryl ether-40 sulfate, sodium lauryl ether-7 tartrate, disodium lauryliminodipropionate, disodium lauryliminodipropionate, sodium lauroyl amphoteric hydroxypropyl sulfonate, sodium lauroyl amphoteric PG-acetate phosphate. Sodium lauroyl amphoteric propionate, sodium lauroyl aspartate, sodium lauroyl collagen amino acid, sodium lauroyl glycine propionate, sodium lauroyl hydrolyzed collagen, sodium lauroyl hydrolyzed silk, sodium lauroyl hydroxypropyl sulfonate, sodium lauroyl hydroxyethanesulfonate, sodium lauroyl methylaminopropionate, sodium lauroyl methyl hydroxyethyl sulfonate, sodium lauroyl Millet amino acid, sodium lauroyl / myristoyl aspartate, sodium lauroyl oat amino acid, sodium lauroyl sarcosine, sodium lauroyl silk amino acid, sodium lauroyl taurate, sodium lauroyl wheat amino acid, sodium lauryl di(ethylenediamino)aminoacetate, sodium lauryl glucoside carboxylate, sodium lauryl glucoside hydroxypropyl phosphate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauryl glycol carboxylate, sodium lauryl hydroxyacetamide sulfate.Disodium lauryl phosphate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium linoleate, sodium macadamia seed oil oleate, sodium mango oleoyl amphoteric acid ester, sodium mango seed oil ester, sodium laureth-2 sulfosuccinate / MEA, sodium methoxyPPG-2 acetate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, sodium methyl oleoyl taurate, sodium methyl palmitoyl taurate, sodium methyl stearyl taurate, sodium methyl 2-sulfolanoate, sodium methyl 2-sulfopalmitoate, sodium isopalmitoyl methyl taurate, sodium methyl taurate cocoyl methyl taurate. Sodium myristyl ether sulfate, sodium myristate, sodium myristoyl amphoteric acid, sodium myristoyl glutamate, sodium myristoyl hydrolyzed collagen, sodium myristoyl ethanesulfonate, sodium myristoyl sarcosine, sodium myristyl sulfate, sodium nonylphenol polyether-6 phosphate, sodium nonylphenol polyether-9 phosphate, sodium nonylphenol polyether-1 sulfate, sodium nonylphenol polyether-3 sulfate, sodium nonylphenol polyether-4 sulfate, sodium nonylphenol polyether-6 sulfate, sodium nonylphenol polyether-8 sulfate, sodium nonylphenol polyether-10 sulfate, sodium nonylphenol polyether-25 sulfate, sodium octylphenol polyether-2 ethanesulfonate, sodium octylphenol polyether... Sodium oleate-2, sodium octylphenol polyether-6, sodium octylphenol polyether-9, sodium oleate, sodium oleoyl amphoteric acid, sodium oleoyl amphoteric hydroxypropyl sulfonate, sodium oleoyl amphoteric propionate, sodium oleoyl hydrolyzed collagen, sodium oleoyl ethanesulfonate, sodium oleyl alcohol polyether sulfate, sodium oleoyl methyl hydroxyethanesulfonate, sodium oleyl alcohol sulfate, sodium oleoyl amphoteric acid, sodium oleoyl glutamate, sodium palmitoleoyl amphoteric acid, sodium palmitate, sodium palmitate glyceryl palmitate sulfonate, sodium palmitate, sodium palmitoyl hydrolyzed collagen, sodium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosinate, sodium palm kernel oleate. Sodium palmitoyl ethanesulfonate, sodium palmitoyl glutamate, sodium passionflower seed oil, sodium arachidonic acid, sodium arachidonic acid, PEG-6 sodium cocoamide carboxylate, PEG-8 sodium cocoamide carboxylate, PEG-4 sodium cocoamide sulfate, PEG-3 sodium lauramide carboxylate, PEG-4 sodium lauramide carboxylate, PEG-8 sodium palm oil glyceride carboxylate, pentaerythritol hydroxypropyl iminodiacetic acid sodium resin, propoxylated PPG-2 sodium acetate, sodium rapeseed oil, sodium rice bran oleoyl amphoteric acid, sodium ricinoleate, sodium ricinoleoyl amphoteric acid, Sodium Rose Hipsamphoacetate, Sodium Rosinate, Sodium Safflower Oil, Sodium Saffloweroyl Hydrolyzed Soybean Protein, Sodium Sesame Seed Oil, Sodium Sesame Amphoteric Acetate, Sodium Butyl Amphoteric Acetate, Sodium Soybean Oil, Sodium Soybean Oil Hydrolyzed Collagen, Sodium Stearate, Sodium Stearyl Amphoteric Acetate, Sodium Stearyl Hydroxypropyl Sulfonate, Sodium Stearyl Amphoteric Propionate, Sodium Stearyl Casein, Sodium Stearyl Glutamate, Sodium Stearyl Hyaluronic Acid, Sodium Stearyl Hydrolyzed Collagen, Sodium Stearyl Hydrolyzed Corn Protein, Sodium Stearyl Hydrolyzed Silk.Sodium stearoyl hydrolyzed soybean protein, sodium stearoyl hydrolyzed wheat protein, sodium stearoyl whey protein, sodium sodium stearoyl methyl hydroxyethanesulfonate, sodium stearoyl oat protein, sodium stearoyl pea protein, sodium stearoyl soybean protein, sodium stearoyl dimethyl glycinate, sodium stearyl alcohol sulfate, sodium sunflower seed oleoyl amphotericin, sodium subtilis lipopeptide, sodium sweet almond oleoyl amphotericin, sodium sweet almond oil, sodium tallow oleoyl amphotericin, sodium tallowate, sodium tallow oleoyl amphotericin, sodium tallow alcohol sulfate, Callophyllum Inophyllium (INOPHYLLUM) Sodium seed oil, Sodium taurate, Sodium cocoyl methyl taurate, Sodium lauroyl taurate, Sodium lauroyl collagen amino acid / TEA salt, Sodium lauroyl hydrolyzed collagen / TEA salt, Sodium lauroyl hydrolyzed keratin salt / TEA salt, Sodium lauroyl keratin amino acid / TEA salt, Sodium undecenoyl collagen amino acid / TEA salt, Sodium undecenoyl hydrolyzed collagen / TEA salt, Sodium undecenoyl hydrolyzed corn gluten / TEA salt, Sodium undecenoyl hydrolyzed soybean gluten / TEA salt, Sodium undecenoyl hydrolyzed wheat gluten / TEA salt, Theobroma (Coccoa macrophylla) GRANDIFLORUM) Sodium seed oil, sodium tridecyl alcohol polyether-3 carboxylate, sodium tridecyl alcohol polyether-4 carboxylate, sodium tridecyl alcohol polyether-6 carboxylate, sodium tridecyl alcohol polyether-7 carboxylate, sodium tridecyl alcohol polyether-8 carboxylate, sodium tridecyl alcohol polyether-12 carboxylate, sodium tridecyl alcohol polyether-15 carboxylate, sodium tridecyl alcohol polyether-19 carboxylate, sodium tridecyl alcohol polyether sulfate, sodium tridecylbenzene sulfonate, sodium tridecyl alcohol sulfate, sodium trimethylolpropane hydroxypropyl iminodiacetic acid (TAPHA) resin, sodium undecyl alcohol polyether-5 carboxylate, sodium undecenoate, sodium undecenoyl amphoteric acid, sodium undecenoyl amphoteric propionate, disodium undecenoyl glutamate, sodium wheat germ oil amphoteric acid, sorbitol polyether-160 tristearate, soybean oleic acid, soybean oleamide propylamine oxide, soybean oleamide propyl betaine, soybean glyceryl polyether-8 ester, isostearamide propylamine oxide Stearoamide propyl betaine, stearamide oxide, stearyl alcohol polyether-15, stearyl alcohol polyether-16, stearyl alcohol polyether-20, stearyl alcohol polyether-21, stearyl alcohol polyether-25, stearyl alcohol polyether-27, stearyl alcohol polyether-30, stearyl alcohol polyether-40, stearyl alcohol polyether-50, stearyl alcohol polyether-80, stearyl alcohol polyether-100, stearyl alcohol polyether-2 phosphate, stearyl alcohol polyether-3 phosphate, stearic acid, stearoxypropyltrimethyl Stearoyl glutamic acid, stearoyl sarcosine, stearyl betaine, stearyl dimethyl butyl glucoside hydroxypropyl ammonium chloride, stearyl dimethyl decyl glucoside hydroxypropyl ammonium chloride, stearyl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, sulfated castor oil, sulfated coconut oil, sulfated glyceryl oleate, sulfated olive oil, sulfated peanut oil, sunflower oil oleamide MEA, sunflower seed oleic acid, sunflower seed oleamide propyl hydroxyethyl dimethyl ammonium chloride,Sunflower seed oil glyceryl polyether-8 esters, tallow acid, tallow acid, tallow amamidopropylamine oxide, tallow amamidopropyl betaine, tallow amamidopropyl hydroxysulfonyl betaine, tallow amamidoamine oxide, tallow betaine, tallow dihydroxyethyl betaine, tallow ethyl glucoside, abietic hydrolyzed collagen TEA salt, C12-14 alcohol phosphate TEA salt, C10-15 alkyl sulfate TEA salt, C11-15 alcohol sulfate TEA salt, C12-13 alkyl sulfate TEA salt, TEA-C12-14 alkyl sulfate TEA salt, TEA-C12-15 alkyl sulfate TEA salt, TEA C14-17 secondary alkyl sulfonic acid TEA salt, low erucic acid rapeseed oil TEA salt, cocamidodiacetic acid TEA salt, coconut oil acid TEA salt, coconut oil alcohol sulfate TEA salt, cocoyl alanine TEA salt, cocoyl glutamic acid TEA salt, cocoyl glutamine TEA salt, cocoyl glycine TEA salt, cocoyl hydrolyzed collagen TEA salt, cocoyl hydrolyzed soy protein TEA salt, cocoyl sarcosine TEA salt, polydimethylsiloxane PEG-7 phosphate TEA salt, dodecylbenzene sulfonic acid TEA salt, hydrogenated coconut oil acid TEA salt, hydrogenated tallow glutamic acid TEA salts, isostearic acid TEA salts, TEA-isostearoyl hydrolyzed collagen TEA salts, lauryl aminopropionic acid TEA salts, lauric acid TEA salts, lauric acid / myristic acid TEA salts, lauryl polyether sulfate TEA salts, lauroyl collagen amino acid TEA salts, lauroyl glutamate TEA salts, lauroyl hydrolyzed collagen TEA salts, lauroyl keratin amino acid TEA salts, lauroyl methylaminopropionic acid TEA salts, lauroyl / myristoyl aspartic acid TEA salts, lauroyl sarcosine TEA salts, lauryl phosphate TEA salts, lauryl sulfate TEA salts, and more. Myristic acid TEA salt, myristic acid TEA salt, myristoyl hydrolyzed collagen TEA salt, oleic acid TEA salt, oleoyl hydrolyzed collagen TEA salt, oleoyl sarcosine TEA salt, oleyl alcohol sulfate TEA salt, palmitic acid TEA salt, palm kernel sarcosine TEA salt, PEG-3 cocamidosulfate TEA salt, rosinic acid TEA salt, stearic acid TEA salt, tall acid TEA salt, tridecylbenzenesulfonic acid TEA salt, undecenoic acid TEA salt, undecenoyl hydrolyzed collagen TEA salt, tetramethyldecynyl glycol, tetrasodium dicarboxyethyl stearyl sulfosuccinate, lauryl... TiPaeonia succinate (TIPA), Lauryl sulfate (TIPA), Myristic acid (TIPA), Stearic acid (TIPA), Tocopheryl phosphate, Trehalose undecenoate, TM-C12-15 Alkyl ether-2 phosphate, TM-C12-15 Alkyl ether-6 phosphate, TM-C12-15 Alkyl ether-8 phosphate, TM-C12-15 Alkyl ether-10 phosphate, Tridecyl alcohol polyether-20, Tridecyl alcohol polyether-50, Tridecyl alcohol polyether-3 carboxylic acid, Tridecyl alcohol polyether-4 carboxylic acid, Tridecyl alcohol polyether-7 carboxylic acid, Tridecyl alcohol polyether-8 carboxylic acidTridecyl alcohol polyether-15 carboxylic acid, tridecyl alcohol polyether-19 carboxylic acid, tridecyl alcohol polyether-10 phosphate, tridecylbenzene sulfonic acid, tris(lauroyl polyether-9) citrate, trimethylolpropane hydroxypropyl dihydroxyethylamine resin, tris(lauroyl amphoteric PG-acetic acid sodium chloride) phosphate, undecanoic acid, undecyl alcohol polyether-5 carboxylic acid, undecenoyl ammonium amine oxide, undecenoyl ammonium betaine, undecenoic acid, undecenoyl collagen amino acid, undecenoyl glycine, undecenoyl hydrolyzed collagen, undecenoyl wheat amino acids, undecyl glucoside, wheat germ fatty acid, wheat germ oleamide propylamine oxide, wheat germ oleamide propyl betaine, Yucca schidigera leaf / root / stem extract, Yucca schidigera stem extract, zinc cocoyl alcohol polyether sulfate and zinc cocoyl alcohol sulfate.

[0084] Preferably, it is selected from one or more compounds including sodium lauryl ether sulfate, cocamidopropyl betaine, sodium coamphoacetate, cocoyl glucoside and ammonium lauryl sulfosuccinate.

[0085] The percentage content of the surfactant in the formulation can be from 0.1 to 10% by weight, and preferably from 0.5 to 5% by weight, based on the formulation.

[0086] oil body

[0087] A suitable oil body, which is a component of an O / W emulsion, is, for example, an ester of a straight-chain C6-C22-fatty acid and a straight-chain or branched C6-C22-aliphatic alcohol containing 6 to 18, preferably 8 to 10, Guerbet alcohols, or a branched C6-C13-carboxylic acid and a straight-chain or branched C6-C13-carboxylic acid. Esters of 22-aliphatic alcohols, such as, for example, tetradecyl myristate, tetradecyl palmitate, tetradecyl stearate, tetradecyl isostearate, tetradecyl oleate, tetradecyl behenate, tetradecyl erucate, hexadecyl myristate, hexadecyl palmitate, hexadecyl stearate, hexadecyl isostearate, hexadecyl oleate, hexadecyl behenate, hexadecyl erucate, octadecyl myristate, octadecyl palmitate, octadecyl stearate, octadecyl isostearate, octadecyl oleate, octadecyl behenate, octadecyl erucate, isooctadecyl myristate, isooctadecyl palmitate, stearate Isooctadecyl isostearate, isostearate, isostearate oleate, isostearate behenate, isostearate oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, behenate oleyl oleate, oleyl erucic acid, myristate docosyl ester, palmitate docosyl ester, stearate docosyl ester, isostearate docosyl ester, oleate docosyl ester, behenate docosyl ester, myristate mustard ester, palmitate mustard ester, stearate mustard ester, isostearate mustard ester, oleate mustard ester, behenate mustard ester and mustard mustard ester. Additionally, suitable options include esters of straight-chain C6-C22-fatty acids with branched-chain alcohols, particularly 2-ethylhexanol; esters of C18-C38-alkylhydroxycarboxylic acids with straight-chain or branched C6-C22-aliphatic alcohols, particularly dioctyl malate; esters of straight-chain and / or branched-chain fatty acids with polyols (such as, for example, propylene glycol, dimerdiol, or trimertriol) and / or Guerbet alcohol; and glycerols based on C6-C10-fatty acids. Esters, mixtures of liquid mono- / di- / triglycerides based on C6-C18 fatty acids, esters of C6-C22-aliphatic alcohols and / or Guerbet alcohols with aromatic carboxylic acids, particularly benzoic acid, esters of C2-C12-dicarboxylic acids with straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, carbonates of straight-chain and branched C6-C22-aliphatic alcohols, such as, for example, dioctyl carbonate ( CC), Guerbet carbonates based on aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms, and esters of benzoic acid with straight-chain and / or branched C6-C22-ols (e.g., C6-C22-ols). TN), straight-chain or branched, symmetrical or asymmetrical dialkyl ethers, each alkyl group having 6 to 22 carbon atoms, such as, for example, dioctyl ether (TN). OE), ring-opening products of epoxidized fatty acid esters and polyols, silicone oils (cyclodimethylsiloxane, silicone methyl silicone oil grade, etc.) and / or aliphatic hydrocarbons or cycloalkanes, such as squalane, squalene or dialkylcyclohexane.

[0088] emulsifier

[0089] Other nonionic or cationic surfactants can also be added to formulations as emulsifiers, including, for example:

[0090] • 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with straight-chain C 8-22 Aliphatic alcohols, and C 12-22 Addition products of fatty acids and alkylphenols having 8-15 carbon atoms in the alkyl group;

[0091] • The C10 of the addition products of 1 to 30 moles of ethylene oxide to glycerol 12 / 18 Fatty acid monoesters and diesters;

[0092] • Saturated and unsaturated fatty acid mono- and diesters containing 6 to 22 carbon atoms and dehydrated sorbitol mono- and diesters and their ethylene oxide addition products;

[0093] • Addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil;

[0094] • Polyol esters, especially polyglycerol esters, such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate, or polyglycerol dimeric oleoisostearate. Mixtures of several such compounds are also applicable;

[0095] • Addition products of 2 to 15 moles of ethylene oxide with castor oil and / or hydrogenated castor oil;

[0096] • Based on straight chain, branched chain, unsaturated or saturated C 6 / 22 Fatty acids, ricinoleic acid, 12-hydroxystearic acid, and glycerol

[0097] Esters of oils, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g., sorbitol), alkyl glucosides (e.g., methyl glucoside, butyl glucoside, lauryl glucoside), and polyglucosides (e.g., cellulose);

[0098] • Mono-, di-, and trialkyl phosphates, as well as mono-, di-, and / or tri-PEG alkyl phosphates and their salts;

[0099] • Lanolin alcohols;

[0100] • Polysiloxane / polyalkyl polyether copolymers and their derivatives;

[0101] • A mixture of pentaerythritol, fatty acids, citric acid, and aliphatic alcohols and / or C 6-22 Fatty acids, methyl glucose and polyols, preferably a mixture of glycerol or polyglycerol;

[0102] Polydiols and

[0103] • Glyceryl carbonate.

[0104] The addition products of ethylene oxide and / or propylene oxide with aliphatic alcohols, fatty acids, and alkylphenols, as well as glycerol mono- and diesters and anhydrous sorbitol mono- and diesters of fatty acids or castor oil, are commercially available products. Here, we refer to homologous mixtures whose average degree of alkoxylation corresponds to the ratio of ethylene oxide and / or propylene oxide to the matrix in the addition reaction. The C1 of the ethylene oxide-glycerol addition product... 12 / 18 Fatty acid monoesters and diesters are known to be used as fat enriching agents in cosmetic formulations. Preferred emulsifiers are listed in detail below:

[0105] Metaglycerides. Typical examples of suitable metaglycerides are glyceryl monohydroxystearate, glyceryl dihydroxystearate, glyceryl isostearate, glyceryl isostearate, glyceryl monooleate, glyceryl dioleate, glyceryl ricinoleate, glyceryl ricinoleate, glyceryl linoleate, glyceryl dioleate, glyceryl monooleate, glyceryl linoleate, glyceryl erucic acid, glyceryl dioleucic acid, glyceryl tartrate, glyceryl tartrate, glyceryl monocitrate, glyceryl citrate, glyceryl malate, glyceryl malate, and technical mixtures thereof that still contain small amounts of triglycerides derived from the production process. Addition products of 1 to 30, preferably 5 to 10 moles of ethylene oxide with the above-mentioned metaglycerides are also suitable.

[0106] Sorbitol esters. Suitable sorbitol esters include sorbitol monoisostearate, sorbitol sesquiisostearate, sorbitol diisostearate, sorbitol triisostearate, sorbitol monooleate, sorbitol sesquioleate, sorbitol dioleate, sorbitol trioleate, sorbitol monoerucic acid ester, sorbitol sesquierucic acid ester, sorbitol dierucic acid ester, sorbitol trierucic acid ester, sorbitol monoricinoleate, sorbitol sesquirucic acid ester, sorbitol diricinoleate, sorbitol triricinoleate, and sorbitol monoricinoleate. Sorbitol monohydroxy stearate, sorbitan sesquihydroxy stearate, sorbitan dihydroxy stearate, sorbitan trihydroxy stearate, sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate, and mixtures thereof. Addition products of 1 to 30, preferably 5 to 10 moles of ethylene oxide with the above-mentioned sorbitan esters are also suitable.

[0107] Polyglycerol esters. A typical example of a suitable polyglycerol ester is polyglycerol-2-dimeric hydroxystearate (…). PGPH), polyglycerol-3-diisostearate ( TGI), polyglycerol-4 isostearate ( GI 34), polyglycerol-3 oleate, polyglycerol-3 diisostearate ( PDI), polyglycerol-3-methylglucose distearate (Tego) 450), polyglycerol-3 beeswax (Cera) ), polyglycerol-4-decanoate (polyglycerol decanoate T2010 / 90), polyglycerol-3-ceryl ether ( NL), polyglycerol-3 distearate ( GS 32) and polyglycerol polyricinoleate ( WOL 1403), polyglyceryl diisostearate esters, and mixtures thereof. Other suitable examples of polyol esters are monoesters, diesters, and trimers of lauric acid, coconut oil acid, tartrate, palmitic acid, stearic acid, oleic acid, behenic acid, etc., reacted with 1 to 30 moles of ethylene oxide with trimethylolpropane or pentaerythritol.

[0108] Tetraalkyl quaternary ammonium salts. Cationic surfactants in aqueous solution contain hydrophobic polymer groups required for the surface activity of the dissociated cation. An important representative of cationic surfactants is the general formula (R...).1 R 2 R 3 R 4 N + )X - A tetraalkyl quaternary ammonium salt. Where R1 represents a C1-C8 alkyl (alkene) group, R... 2 ,R 3 and R 4 Each of these groups independently represents an alkyl (alkene) group containing 1 to 22 carbon atoms. X is a counterion, preferably from halogens, alkyl sulfates, and alkyl carbonates. Cationic surfactants are particularly preferred, wherein the nitrogen atom is replaced by two long acyl groups and two short alkyl (alkene) groups.

[0109] Ester quaternary ammonium salts. A group of cationic surfactants, particularly used as co-surfactants in this invention, are so-called ester quaternary ammonium salts. Ester quaternary ammonium salts generally refer to quaternized fatty acid triethanolamine esters. They are known compounds that can be obtained by methods related to preparative organic chemistry. Reference is made in this regard to International Patent Application WO 91 / 01295A1, in which triethanolamine is partially esterified with a fatty acid in the presence of hypophosphite, air is passed through the reaction mixture, and subsequently the entire mixture is quaternized with dimethyl sulfate or ethylene oxide. Furthermore, German Patent DE 4308794 C1 discloses a method for preparing solid ester quaternary ammonium salts, wherein the quaternization of triethanolamine esters is carried out in the presence of a suitable dispersant, preferably a fatty alcohol.

[0110] A typical example of an ester quaternary ammonium salt suitably used according to the invention is a product whose acyl group is derived from a monocarboxylic acid corresponding to the formula RCOOH, wherein RCO is an acyl group containing 6 to 10 carbon atoms, and the amino group is triethanolamine (TEA). Examples of such monocarboxylic acids are hexanoic acid, octanoic acid, decanoic acid, and technical mixtures thereof, such as, for example, so-called head fractionated fatty acids. Preferred ester quaternary ammonium salts are those whose acyl group is derived from a monocarboxylic acid containing 8 to 10 carbon atoms. Other ester quaternary ammonium salts are those products whose acyl group is derived from dicarboxylic acids such as malonic acid, succinic acid, maleic acid, fumaric acid, glutaric acid, sorbic acid, pimelic acid, azelaic acid, sebacic acid, and / or dodecanoic acid, but adipic acid is preferred. In summary, preferred ester quaternary ammonium salts are those whose acyl group is derived from a mixture of monocarboxylic acids and adipic acid containing 6 to 22 carbon atoms. In the final ester quaternary ammonium salt, the molar ratio of monocarboxylic acid to dicarboxylic acid is 1:99 to 99:1, and preferably 50:50 to 90:10, and particularly 70:30 to 80:20. Besides quaternized fatty acid triethanolamine esters, other suitable ester quaternary ammonium salts are mixtures of mono / dicarboxylic acids with diethanolalkylamine or 1,2-dihydroxypropyldialkylamine. Esters can be obtained by mixing fatty acids and the corresponding triglycerides with the corresponding dicarboxylic acids. One such method, which can be considered representative of the relevant prior art, is described in European Patent EP 0750606 B1. For the production of quaternized esters, the molar ratio of the mixture of mono and dicarboxylic acids and triethanolamine—based on the available carboxyl group functions—can be 1.1:1 to 3:1. Considering the properties of ester quaternary ammonium salts, ratios that have proven particularly advantageous are 1.2:1 to 2.2:1, and preferably 1.5:1 to 1.9:1. Preferred ester quaternary ammonium salts are technical mixtures of mono-, di-, and tri-esters with an average degree of esterification of 1.5 to 1.9.

[0111] Fat enrichment agents and consistency factors

[0112] The fat enrichment agent can be selected from substances such as lanolin and lecithin, as well as polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides, among which fatty acid alkanolamides can also be used as foam stabilizers.

[0113] The main consistency factors used are aliphatic alcohols or hydroxyaliphatic alcohols containing 12 to 22, preferably 16 to 18, carbon atoms, as well as glyceryl esters, fatty acids, or hydroxy fatty acids. These substances are preferably used in combination with alkyl oligoglucosides and / or fatty acids of the same chain length, N-methylglucamide, and / or polyglycerol poly-12-hydroxystearate.

[0114] Thickeners and rheology modifiers

[0115] Suitable thickeners are polymeric thickeners, such as... Hydrophilic silica, polysaccharides, especially xanthan gum, guar gum, agar, alginate and tyloses, carboxymethyl cellulose and hydroxyethyl and hydroxypropyl cellulose, and relatively high molecular weight polyethylene glycol monoesters and diesters, polyacrylates (e.g.) [Goodrich] or [Sigma]), polyacrylamide, polyvinyl alcohol and polyvinylpyrrolidone, surfactants such as ethoxylated fatty acid glycerides, fatty acids and polyols such as pentaerythritol or trimethylolpropane esters, aliphatic alcohol ethoxylates with narrow homologue distributions, and electrolytes such as sodium chloride and ammonium chloride.

[0116] polymer

[0117] Suitable cationic polymers are, for example, cationic cellulose derivatives, such as those available from Amerchol.

[0118] Polymer JR The names obtained are quaternized hydroxyethyl cellulose, cationic starch, diallyl ammonium salt and acrylamide copolymers, quaternized vinylpyrrolidone / vinylimidazol polymers, for example (BASF), condensates of polyethylene glycol and amines, quaternized collagen peptides, such as lauryl diammonium hydroxypropyl hydrolyzed collagen ( L, Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic organosilicon polymers, such as amino polydimethylsiloxane, adipic acid and a copolymer of dimethylaminohydroxypropyl diethylenetriamine ( Sandoz), a copolymer of acrylic acid and dimethyl diallyl ammonium chloride ( 550, Chemviron), polyamino polyamides and their crosslinked water-soluble polymers, cationic chitin derivatives, such as quaternized chitosan, optionally with microcrystalline distribution, dihaloalkanes, such as dibromobutane, condensation products with dialkylamines, such as dimethylamino-1,3-propane, cationic guar gum, such as Celanese CBS C-17 C-16, quaternary ammonium salt polymers, such as Miranol. A-15 AD-1, AZ-1, and can be marketed under the trade name CC or 300 found various polyquaternium salt types (e.g., 6, 7, 32, or 37).

[0119] Suitable anionic, amphoteric, amphoteric, and nonionic polymers are, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked and polyol-crosslinked polyacrylic acid, acrylamide propyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinylcaprolactam terpolymers, and optionally derived cellulose ethers and organosilicones.

[0120] Pearl wax

[0121] Suitable pearlescent waxes are, for example, alkyl glycol esters, especially ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamides; glyceryl esters, especially monoglycerides of stearate; esters of poly(substituted carboxylic acids) with aliphatic alcohols having 6-22 carbon atoms, especially long-chain esters of tartaric acid; aliphatic substances having a total of at least 24 carbon atoms, such as aliphatic alcohols, aliphatic ketones, aliphatic aldehydes, aliphatic ethers and aliphatic carbonates, especially lauryl ketones and distearates; fatty acids such as stearic acid, hydroxystearic acid or behenic acid; ring-opening products of epoxyolefins having 12-22 carbon atoms and aliphatic alcohols having 12-22 carbon atoms and / or polyols having 2-15 carbon atoms and 2-10 hydroxyl groups, and mixtures thereof.

[0122] silicone

[0123] Suitable silicones are selected from the group including: theophylline methylsilanol mannouronate, acetyl methionyl methylsilanol elastomeric ester, acrylates / behenol acrylate, acrylates / behenol methacrylate / polydimethylsiloxane methacrylate copolymer, acrylates / behenol methacrylate / polydimethylsiloxane methacrylate copolymer, acrylates / dihydroxypropyl polydimethylsiloxane crosspolymer, acrylates / polydimethylsiloxane copolymer, acrylates / polydimethylsiloxane methacrylate / ethylhexyl acrylate copolymer, acrylates / polydimethylsiloxane alcohol acrylate copolymer, acrylates / ethylhexyl acrylate / polydimethylsiloxane crosspolymer. Methylsiloxane methacrylate copolymer, acrylates / octylacrylamide / diphenylamino-terminated polydimethylsiloxane copolymer, acrylates / polytrimethylsiloxane methacrylate copolymer, acrylates / propyl polytrimethylsiloxane methacrylate copolymer, acrylates / stearyl acrylate / polydimethylsiloxane methacrylate copolymer, acrylates / tridecyl acrylate / triethoxysilylpropanol methacrylate / polydimethylsiloxane methacrylate copolymer, acrylates / trifluoropropyl methacrylate / polytrimethylsiloxane methacrylate copolymer, aminodipropylpolydimethylsiloxane, aminoethylaminopropylpolydimethylsiloxane, aminopropylpolydimethylsiloxane... Dimethylsiloxane, aminopropylphenyl polytrimethylsiloxane, aminopropyltriethoxysilane, polydimethylsiloxane PEG-7 ammonium sulfate, amino-terminated polydimethylsiloxane, amino-terminated polydimethylsiloxane hydroxystearate, amino-terminated polydimethylsiloxane / silsesquioxane copolymer, ascorbic acid carboxydecyl trisiloxane, ascorbic acid methylsilanol pectate, behenoxy polydimethylsiloxane, behenyltrimethylammonium polydimethylsiloxane PEG-8 phthalate, behenyl polydimethylsiloxane, diaminoPEG / PPG-41 / 3 aminoethyl PG-propyl polydimethylsiloxane, bis-aminopropyl / ethoxyaminopropyl polydimethylsiloxane, bis(butyl benzoate) diaminotriazine aminopropyltrisiloxane, bis-butyl polydimethylsiloxane Oxyalkyl polyglycerol-3, bis-butoxyamino-terminated polydimethylsiloxane / PEG-60 copolymer, bis(C13-15alkoxy)hydroxybutamidoamino-terminated polydimethylsiloxane, bis(C13-15alkoxy)PG-amino-terminated polydimethylsiloxane, bis-(C1-8 alkyllauroyl lysine decyl formamide) polydimethylsiloxane, bis-cetylcetyl polydimethylsiloxane, bis-cetyl / PEG-8cetyl PEG-8 dimethylsiloxane, bis-diphenylethyl dipolysiloxane, bis-ethylethyl polymethylsiloxane, bis-glucamide ethyl-aminopropyl dipolysiloxane, bis-hydrogen polydimethylsiloxane, bis-hydroxyethoxypropyl dipolysiloxane, bis-hydroxylauryl, polydimethylsiloxane / IPDI copolymerBis-hydroxy / methoxyamine-terminated polydimethylsiloxane, bis-hydroxypropyl dimethylsiloxane behenate, bis-hydroxypropyl polydimethylsiloxane / SMDI copolymer, bis-isobutyl PEG-14 / polydimethylsiloxane copolymer, bis-isobutyl PEG-15 / polydimethylsiloxane copolymer, bis-isobutyl PEG / PPG-20 / 35 / polydimethylsiloxane copolymer, bis-isobutyl PEG / PPG-10 / 7 / polydimethylsiloxane copolymer, bis-isobutyl PEG-24 / PPG-7 / didimethylsiloxane copolymer, bis-PEG-1 polydimethylsiloxane, bis-PEG-4 polydimethylsiloxane, bis-PEG-8 polydimethylsiloxane, bis-PEG-12 polydimethylsiloxane Methylsiloxane, bis-PEG-20 polydimethylsiloxane, bis-PEG-12 polydimethylsiloxane beeswax ester, bis-PEG-12 polydimethylsiloxane candelilla wax ester, bis-PEG-15 polydimethylsiloxane / IPDI copolymer, bis-PEG-15 methyl ether polydimethylsiloxane, bis-PEG-18 methyl ether dimethylsiloxane, bis-PEG / PPG-14 / 14 polydimethylsiloxane, bis-PEG / PPG-15 / 5 polydimethylsiloxane, bis-PEG / PPG-18 / 6 polydimethylsiloxane, bis-PEG / PPG-20 / 20 polydimethylsiloxane, bis-PEG / PPG-16 / 16PEG / PPG-16 / 16 polydimethylsiloxane Bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 polydimethylsiloxane, bisphenylhexamethylsiloxane, bis-phenylpropyl polydimethylsiloxane, bispolyethylene polydimethylsiloxane, bis(polyglycerol-3-hydroxyphenylpropyl) polydimethylsiloxane, bis(polyglycerol-7-hydroxyphenylpropyl) polydimethylsiloxane, bis-PPG-15 polydimethylsiloxane / IPDI copolymer, bis(PPG-7 undecenol polyether-21) polydimethylsiloxane, bis-stearyl polydimethylsiloxane, bis-trimethoxysilylethyltetramethyldisiloxyl polydimethylsiloxane, bis-vinyl polydimethylsiloxane, bis-vinyl polydimethylsiloxane / polydimethylsiloxane copolymer, borage seed oil PEG- 7. Polydimethylsiloxane esters, butyl acrylate / C6-14 perfluoroalkyl ethanol acrylate / mercaptopropyl polydimethylsiloxane copolymer, butyl acrylate / hydroxypropyl polydimethylsiloxane acrylate copolymer, butyl polydimethylsiloxane acrylate / cyclohexyl methacrylate / ethylhexyl acrylate copolymer, butyl polydimethylsiloxane methacrylate / methyl methacrylate crosspolymer, tert-butyldimethylsiloxane grape seed extract, butyl polydimethylsiloxane ethylene / propylene / ethylene norbornene copolymer, C6-8 alkylC3-6 alkyl glucoside polydimethylsiloxane, C20-24 alkyl polydimethylsiloxane, C24-28 alkyl polydimethylsiloxane, C26-28 alkyl polydimethylsiloxane,C30-45 alkyl polydimethylsiloxane, C30-60 alkyl polydimethylsiloxane, C32 alkyl polydimethylsiloxane, C30-45 alkyl polydimethylsiloxane / polycyclohexene oxide crosslinked polymer, C26-28 alkanol dimethylsilane polypropylsilsesquioxane, C30-45 alkanol dimethylsilane polypropylsilsesquioxane, C20-24 alkyl polymethylsiloxane, C24-28 alkyl polymethylsiloxane, C26-28 alkyl polymethylsiloxane, C30-45 alkyl polymethylsiloxane, C20-28 alkyl polymethylsiloxane Fluorodecylethoxy polydimethylsiloxane, C26-54 alkyltetradecane polydimethylsiloxane, octyl polydimethylsiloxane, octyl polydimethylsiloxane ethoxyglucoside, octyl polymethylsiloxane, octyl polytrimethylsiloxane, carboxydecyltrisiloxane, castor oil bis-hydroxypropyl polydimethylsiloxane esters, wax-based polydimethylsiloxane, cetearyl polydimethylsiloxane crosspolymer, cetearyl polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, cetearyl polymethylsiloxane, cetrimonium carboxydecyl PEG-8 polydimethylsiloxane Cetyl alkyl salts, cetrimonium polydimethylsiloxane PEG-7 phthalate salts, cetyl behenyl alcohol polydimethylsiloxane salts, cetyl polydimethylsiloxane, cetyl polydimethylsiloxane / bisvinyl polydimethylsiloxane crosspolymer, cetyl hexadecyl polydimethylsiloxane, cetyloxy polydimethylsiloxane, cetyl PEG-8 polydimethylsiloxane, cetyl PEG / PPG-15 / 15 butyl ether polydimethylsiloxane, cetyl PEG / PPG-7 / 3 polydimethylsiloxane, cetyl PEG / PPG-10 / 1 polydimethylsiloxane Methylsiloxane, cetyltriethylammonium polydimethylsiloxane PEG-8 phthalate, cetyltriethylammonium polydimethylsiloxane PEG-8 succinate, acetyltyrosine copper methylsilanol, PCA methylsilanol copper, C4-14 perfluoroalkyl ethoxy polydimethylsiloxane, cycloethoxy polymethylsiloxane, cycloheptane, cyclohexylsiloxane, cyclopolydimethylsiloxane, cyclopentamethoxysiloxane, cyclophenyl polymethylsiloxane, cyclotetramethylsiloxane, cyclovinyl polymethoxysilane, cystine bis-PG-propylsilanetriol, DEA PG-propyl PEG / PPG-18 / 21 polydimethylsiloxane, diisostearoyl trimethylolpropane siloxysilicate, dilauroyl trimethylolpropane siloxane alkylsilicate, di-linoleamide propyl dimethylamine polydimethylsiloxane PEG-7 phosphate, polydimethylsiloxane, polydimethylsiloxane crosspolymer, polydimethylsiloxane crosspolymer-3, polydimethylsiloxane / divinyl polydimethylsiloxane / silsesquioxane crosspolymer, polydimethylsiloxane ethoxyglucoside, polydimethylsiloxane hydroxypropyltrimethylammonium chloride, polydimethylsiloxane / mercaptopropyl polymethylsiloxane copolymer, polydimethylsiloxane PEG-15 acetate.Polydimethylsiloxane PEG-8 adipate, polydimethylsiloxane PEG-7 avocado oleate, polydimethylsiloxane PEG-8 avocado oleate, polydimethylsiloxane PEG-8 beeswax ester, polydimethylsiloxane PEG-8 benzoate, polydimethylsiloxane PEG-8 borage oleate, polydimethylsiloxane PEG-7 cocoate, polydimethylsiloxane / PEG-10 crosspolymer, polydimethylsiloxane.

[0124] PEG-10 / 15 cross-linked polymer, polydimethylsiloxane PEG-15 cross-linked polymer, polydimethylsiloxane PEG-7 isostearate, polydimethylsiloxane PEG-8 isostearate, polydimethylsiloxane PEG-7 lactate, polydimethylsiloxane PEG-8 lanolinate, polydimethylsiloxane PEG-8 laurate, polydimethylsiloxane PEG-8 meadowfoam seed oleate, polydimethylsiloxane PEG-7 octyl dodecyl citrate, polydimethylsiloxane PEG-7 olive oil ester, polydimethylsiloxane PEG-8 olive oil ester, polydimethylsiloxane PEG-7 phosphate, polydimethylsiloxane PEG-8 phosphate, polydimethylsiloxane PEG-10 phosphate. Polydimethylsiloxane PEG-7 phthalate, polydimethylsiloxane PEG-8 phthalate, polydimethylsiloxane PEG-8 polyacrylate, polydimethylsiloxane PEG / PPG-20 / 23 benzoate, polydimethylsiloxane PEG / PPG-7 / 4 phosphate, polydimethylsiloxane PEG / PPG-12 / 4 phosphate, polydimethylsiloxane PEG-7 succinate, polydimethylsiloxane PEG-8 succinate, polydimethylsiloxane PEG-7 sulfate, polydimethylsiloxane PEG-7 undecanoate, polydimethylsiloxane PG-diethylmethylammonium chloride, polydimethylsiloxane / phenylvinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane / polyglycerol- 3. Crosslinked polymers, polydimethylsiloxane / PPG-20 crosslinked polymer, polydimethylsiloxane propyl ethylenediamine behenate, polydimethylsiloxane propyl PG-betaine, polydimethylsiloxane / silsesquioxane copolymer, silylated polydimethylsiloxane, polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer, polydimethylsiloxane / vinyltrimethylsiloxysilicate crosslinked polymer, polydimethylsiloxane alcohol, polydimethylsiloxane alcohol arginine, polydimethylsiloxane alcohol beeswax ester, polydimethylsiloxane alcohol behenate, polydimethylsiloxane alcohol hygroserate, polydimethylsiloxane alcohol candelilla ester, polydimethylsiloxane alcohol brassinate, polydimethylsiloxane alcohol cysteine, polydimethylsiloxane alcohol... Dimethylsiloxane alcohol derupa ester, polydimethylsiloxane alcohol fluoroalcohol di-linoleic acid polyester, polydimethylsiloxane alcohol hydroxystearate, polydimethylsiloxane alcohol Indian hematite resin ester, polydimethylsiloxane alcohol / IPDI copolymer, polydimethylsiloxane alcohol isostearate, polydimethylsiloxane alcohol pine oleate, polydimethylsiloxane alcohol lactate, polydimethylsiloxane alcohol meadowfoam seed oleate, polydimethylsiloxane alcohol methionine, polydimethylsiloxane alcohol / methylsiloxane alcohol / silica ester crosspolymer, polydimethylsiloxane alcohol longleaf limonene lignan ester, polydimethylsiloxane alcohol panthenol, polydimethylsiloxane alcohol salicylate, polydimethylsiloxane / silica crosspolymer, polydimethylsiloxane alcohol / silsesquioxane copolymerPolydimethylsiloxane stearate, polydimethylsiloxane / stearyl polymethylsiloxane / phenyl polytrimethylsiloxane copolymer, dimethoxysilyl ethylene diaminopropyl polydimethylsiloxane, dimethylaminopropionamide PCA polydimethylsiloxane, dimethyloxobenzodioxane, dimethylsilanol hyaluronic acid ester, dioleoyl tocopherol methylsilanol, diphenylamino-terminated polydimethylsiloxane, diphenyl polydimethylsiloxane crosspolymer, diphenyl polydimethylsiloxane / vinyl diphenyl polydimethylsiloxane / silsesquioxane crosspolymer Diphenylethylbenzyloxydimethyldisiloxane, diphenylisopropylpolydimethylsiloxane, diphenylsiloxyphenyl / propylpolytrimethylsiloxane, diphenylsiloxyphenylpolytrimethylsiloxane, dipolysiloxane, ammonia-terminated polydimethylsiloxane / disuccinimid disodium, PEG-12 polydimethylsiloxane sulfosuccinate disodium, PEG-8 lauryl polydimethylsiloxane sulfosuccinate disodium, divinyl polydimethylsiloxane / polydimethylsiloxane copolymer, divinyl polydimethylsiloxane / polydimethylsiloxane crosspolymer, cresoltrazol trisiloxane Ethylhexyl acrylate / VP / polydimethylsiloxane methacrylate copolymer, ethyl polymethylsiloxane, ethyl trisiloxane, fluoroC2-8 alkyl polydimethylsiloxane, glucamipropropyl aminopropyl polydimethylsiloxane, 4-(2-β-pyranose glucomethoxy)propoxy-2-hydroxybenzophenone, glyceryl undecyl polydimethylsiloxane, glycidoxy polydimethylsiloxane, polyhexylmethylsiloxane, hexyl polydimethylsiloxane, hexyl trimethoxysilane, hydrogenated polydimethylsiloxane, hydrogenated polydimethylsiloxane / octylsiloxane Semi-oxane copolymers, hydrolyzed collagen PG-propyl polydimethylsiloxane alcohol, hydrolyzed collagen PG-propyl methylsilane diol, hydrolyzed collagen PG-propyl silane triol, hydrolyzed keratin PG-propyl methylsilane diol, hydrolyzed sesame protein PG-propyl methylsilane diol, hydrolyzed silk PG-propyl methylsilane diol, hydrolyzed silk PG-propyl methylsilane diol crosspolymer, hydrolyzed soybean protein / polydimethylsiloxane PEG-7 acetate, hydrolyzed soybean protein PG-propyl methylsilane diol, hydrolyzed plant protein PG-propyl silane triol, hydrolyzed wheat (TRITICUM) VULGARE protein / cystine bis-PG-propylsilane triol copolymer, hydrolyzed wheat protein / polydimethylsiloxane PEG-7 acetate, hydrolyzed wheat protein / polydimethylsiloxane PEG-7 phosphate copolymer, hydrolyzed wheat protein PG-propylmethylsilane diol, hydrolyzed wheat protein PG-propylsilane triol, hydroxyethyl acetoxymethyl ammonium PG-polydimethylsiloxane, hydroxypropyl polydimethylsiloxane, hydroxypropyl polydimethylsiloxane behenate, hydroxypropyl polydimethylsiloxane isostearate, hydroxypropyl polydimethylsiloxane stearateIsobutyl methacrylate / bis-hydroxypropyl polydimethylsiloxane acrylate copolymer, Isobutyl methacrylate / trifluoroethyl methacrylate / bis-hydroxypropyl polydimethylsiloxane acrylate copolymer, Isoamyl trimethoxycinnamate trisiloxane, Isopolyglycerol-3 polydimethylsiloxane, Isopolyglycerol-3 polydimethylsiloxane alcohol, Isopropyl titanium triisostearate / triethoxysilyl ethyl, Polydimethylsiloxane crosspolymer, Isostearyl carboxydecyl PEG-8 polydimethylsiloxane, Lactoyl methylsilanol elastomeric ester, Lauryl polydimethylsiloxane, Lauryl polydimethylsiloxane PEG-15 crosspolymer, Lauryl polydimethylsiloxane PEG-10 phosphate ester, Lauryl polydimethylsiloxane Siloxane / polyglycerol-3 crosspolymer, lauryl polymethylsiloxane, lauryl PEG-8 polydimethylsiloxane, lauryl PEG-10 methyl ether polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxane-ethyl polydimethylsiloxane, lauryl PEG / PPG-18 / 18 polymethylsiloxane, lauryl phenylisopropyl polymethylsiloxane, lauryl phenylpropyl polymethylsiloxane, lauryl polydimethylsiloxane-ethyl polydimethylsiloxane / divinyl polydimethylsiloxane crosspolymer, lauryl polyglycerol-3 polydimethylsiloxane-ethyl polydimethylsiloxane, lauryl polytrimethylsiloxane, linoleamide-propyl PG-dimethylammonium chloride phosphate polydimethylsiloxane, methacrylpropyltrimethoxysilane, polymethylsiloxane.

[0125] Methoxyamine-terminated polydimethylsiloxane / silsesquioxane copolymer, methoxycinnamoamide propyl polysilsesquioxane, methoxycinnamoyl propyl silsesquioxane silicate, methoxy PEG-13 ethyl polysilsesquioxane, methoxy

[0126] PEG / PPG-7 / 3 aminopropyl polydimethylsiloxane, methoxy PEG / PPG-25 / 4 polydimethylsiloxane, methoxy PEG-10 propyltrimethoxysilane, methyl eugenol PEG-8 polydimethylsiloxane, methyl polysiloxane emulsion, methyl silanol acetylmethionine ester, methyl silanol acetyltyrosine ester, methyl silanol ascorbic acid, methyl silanol carboxymethyl theophylline, methyl silanol carboxymethyl theophylline alginate, methyl silanol elastin ester, methyl silanol glycyrrhizate, methyl silanol hydroxyproline ester, methyl silanol hydroxyproline ester aspartate ester, methyl silanol mannouronate, methyl silanol PCA ester, methyl silanol PEG-7 glyceryl cocoate, methyl silanol / silicate crosslinking Polymers, Methylsilanol Spirulina Protein Ester, Methylsilanol Tri-PEG-8 Glyceryl Cocoate, Methyl Trimethylsiloxane, Methyltrimethoxysilane, Myristamidopropyl Dimethylamine Polydimethylsiloxane PEG-7 Phosphate, Myristyl Polymethylsiloxane, Myristyl Trisiloxane, Nylon-611 / Polydimethylsiloxane Copolymer, PCA Polydimethylsiloxane, PEG-7 Ammonia-Terminated Polydimethylsiloxane, PEG-8 Ammonia-Terminated Polydimethylsiloxane, PEG-8 Cetyl Polydimethylsiloxane, PEG-3 Polydimethylsiloxane, PEG-6 Polydimethylsiloxane, PEG-7 Polydimethylsiloxane, PEG-8 Polydimethylsiloxane, PEG-9 Polydimethylsiloxane, PEG-10 Polydimethylsiloxane, PEG-12 polydimethylsiloxane, PEG-14 polydimethylsiloxane, PEG-polydimethylsiloxane, PEG-10 polydimethylsiloxane cross-linked polymer, PEG-12 polydimethylsiloxane cross-linked polymer, PEG-8 polydimethylsiloxane dimer linoleate, PEG-8 dimer linoleate / di-linoleic acid copolymer, PEG-10 polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, PEG-8 distearate methyl ammonium chloride PG-polydimethylsiloxane, PEG-10 / lauryl polydimethylsiloxane cross-linked polymer, PEG-15 / lauryl polydimethylsiloxane cross-linked polymer, PEG-15 / lauryl polydimethylsiloxane ethyl polydimethylsiloxane PEG-8 polymethylsiloxane, PEG-6 polymethylsiloxane acetate, PEG-6 methyl ether polydimethylsiloxane, PEG-7 methyl ether polydimethylsiloxane, PEG-8 methyl ether polydimethylsiloxane, PEG-9 methyl ether polydimethylsiloxane, PEG-10 methyl ether polydimethylsiloxane, PEG-11 methyl ether polydimethylsiloxane, PEG-32 methyl ether polydimethylsiloxane, PEG-8 methyl ether triethoxysilane, PEG-10 nonafluorohexyl polydimethylsiloxane copolymer, PEG-4 PEG-12 polydimethylsiloxane, PEG-8PG cocoyl glucoside polydimethylsiloxane, PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane.PEG / PPG-20 / 22 butyl ether polydimethylsiloxane, PEG / PPG-22 / 22 butyl ether polydimethylsiloxane, PEG / PPG-23 / 23 butyl ether polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-27 / 9 butyl ether polydimethylsiloxane, PEG / PPG-3 / 10 polydimethylsiloxane, PEG / PPG-4 / 12 polydimethylsiloxane, PEG / PPG-6 / 4 polydimethylsiloxane, PEG / PPG-6 / 11 polydimethylsiloxane, PEG / PPG-8 / 14 polydimethylsiloxane, PEG / PPG-8 / 26 polydimethylsiloxane, PEG / PPG-10 / 2 polydimethylsiloxane PEG / PPG-12 / 16 polydimethylsiloxane, PEG / PPG-12 / 18 polydimethylsiloxane, PEG / PPG-14 / 4 polydimethylsiloxane, PEG / PPG-15 / 5 polydimethylsiloxane, PEG / PPG-15 / 15 polydimethylsiloxane, PEG / PPG-16 / 2 polydimethylsiloxane, PEG / PPG-16 / 8 polydimethylsiloxane, PEG / PPG-17 / 18 polydimethylsiloxane, PEG / PPG-18 / 6 polydimethylsiloxane, PEG / PPG-18 / 12 polydimethylsiloxane, PEG / PPG-18 / 18 polydimethylsiloxane, PEG / PPG-19 / 19 polydimethylsiloxane PEG / PPG-20 / 6 polydimethylsiloxane, PEG / PPG-20 / 15 polydimethylsiloxane, PEG / PPG-20 / 20 polydimethylsiloxane, PEG / PPG-20 / 23 polydimethylsiloxane, PEG / PPG-20 / 29 polydimethylsiloxane, PEG / PPG-22 / 23 polydimethylsiloxane, PEG / PPG-22 / 24 polydimethylsiloxane, PEG / PPG-23 / 6 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane, PEG / PPG-27 / 27 polydimethylsiloxane, PEG / PPG-30 / 10 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG / PPG-24 / 24 methyl ether epoxypropoxy polydimethylsiloxane, PEG / PPG-10 / 3 oil-based ether polydimethylsiloxane, PEG / PPG-5 / 3 trisiloxane, PEG-4 trifluoropropyl polydimethylsiloxane copolymer, PEG-8 trifluoropropyl polydimethylsiloxane copolymer, PEG-10 trifluoropropyl polydimethylsiloxane copolymer, PEG-8 trisiloxane, perfluorooctyltriethoxysilylethyl polymethylsiloxane, perfluorononyl polydimethylsiloxane, perfluorononyl polydimethylsiloxane / polymethylsiloxane / ammonia-terminated polydimethylsiloxane crosslinked polymerPerfluorononylethylcarboxydecylbenzyl polydimethylsiloxane, Perfluorononylethylcarboxydecylhexadecyl polydimethylsiloxane, Perfluorononylethylcarboxydecyllauryl / benzyl polydimethylsiloxane, Perfluorononylethylcarboxydecyllauryl polydimethylsiloxane, Perfluorononylethylcarboxydecyl PEG-8 polydimethylsiloxane, Perfluorononylethylcarboxydecyl PEG-10 polydimethylsiloxane, Perfluorononylethyl polydimethylsiloxane / polymethylsiloxane copolymer, Perfluorononylethyl PEG-8 polydimethylsiloxane, Perfluorononylethyl stearyl polydimethylsiloxane, Perfluorooctylethyl / diphenyl polydimethylsiloxane copolymer, Perfluorooctylethyltriethoxysilane, Perfluorooctylethanoltrimethoxysilane, Perfluorooctylethyltrisiloxane Perfluorooctyltriethoxysilane, PG-ammonia-terminated polydimethylsiloxane, phenethyl polydimethylsiloxane, phenethyl disiloxane, diphenyl polydimethylsiloxane, diphenylisopropyl polydimethylsiloxane, phenyl polymethylsiloxane, phenyl polymethylsiloxane alcohol, phenethyl dimethylsiloxysilicate, phenethyl polymethylsiloxane, phenylpropyl polytrimethylsiloxane, phenylpropyl polytrimethylsiloxane / diphenyl polymethylsiloxane, phenyl polytrimethylsiloxane, divinyldisiloxane platinum, polyacrylate-6, polydiethylsiloxane, polydimethylsiloxyethyl polydimethylsiloxane / divinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane ethyl polydimethylsiloxane / polymethylsiloxane copolymer, polydimethylsiloxane PE G / PPG-24 / 19 Butyl Ether Silsesquioxane, Polydimethylsiloxane PPG-13 Butyl Ether Silsesquioxane, Polyglycerol-3 Disiloxane Polydimethylsiloxane, Polyglycerol-3 / Lauryl Polydimethylsiloxane Ethyl Polydimethylsiloxane Crosspolymer, Polyglycerol-3 Polydimethylsiloxyethyl Polydimethylsiloxane, Poly(ethylene glycol adipate) / Dihydroxyethoxypropyl Polydimethylsiloxane Copolymer, Polymethylsilsesquioxane, Polymethylsilsesquioxane / Trimethylsiloxysilicate, Polyphenylsilsesquioxane, Polypropylsilsesquioxane, Polysiloxane-1, Polysiloxane-2, Polysiloxane-3, Polysiloxane-4, Polysiloxane-5, Polysiloxane-6, Polysiloxane-7, Polysiloxane-8, Polysiloxane-9, Polysiloxane Polysiloxane-10, Polysiloxane-11, Polysiloxane-12, Polysiloxane-13, Polysiloxane-14, Polysiloxane-15, Polysiloxane-16, Polysiloxane-17, Polysiloxane-18, Polysiloxane-19, Polysiloxane-20, Polysiloxane-21, Polysiloxane-18 Cetyl Phosphate, Polysiloxane-1 Crosspolymer, Polysiloxane-18 Stearate Polyurethane-10, Methylsiloxane PEG-7 Panthenol Phosphate Potassium, Polydimethylsiloxane PEG-7 Phosphate Potassium, PPG-12 Butyl Ether Polydimethylsiloxane, PPG-2 Polydimethylsiloxane, PPG-12 Polydimethylsiloxane, PPG-27 Polydimethylsiloxane, PPG-4 Oleyl Alcohol Polyether-10 PolydimethylsiloxanePropoxytetramethylpiperidinyl polydimethylsiloxane, propyl polytrimethylsiloxane, Quaternary ammonium salt-80, retinoxytrimethylsilane, silanediol salicylate, silanetriol, silanetriol arginine ester, silanetriol glutamate ester, silanetriol lysine ester, silanetriol melanin ester, silanetriol trehalose ether, silica, polydimethylsiloxane silylated silica, dimethyl silylated silica, silylated silica, silicon carbide, polysiloxane quaternary ammonium salt-1, polysiloxane quaternary ammonium salt-2, polysiloxane quaternary ammonium salt-2 panthenol succinate, polysiloxane quaternary ammonium salt-3, polysiloxane quaternary ammonium salt-4, polysiloxane quaternary ammonium salt-5, polysiloxane quaternary ammonium salt-6, polysiloxane quaternary ammonium salt-7, polysiloxane quaternary ammonium salt-8, polysiloxane quaternary ammonium Salt-9, Polysiloxane Quaternary Ammonium Salt-10, Polysiloxane Quaternary Ammonium Salt-11, Polysiloxane Quaternary Ammonium Salt-12, Polysiloxane Quaternary Ammonium Salt-15, Polysiloxane Quaternary Ammonium Salt-16, Polysiloxane Quaternary Ammonium Salt-16 / Epoxypropoxy polydimethylsiloxane crosspolymer, Polysiloxane Quaternary Ammonium Salt-17, Polysiloxane Quaternary Ammonium Salt-18, Polysiloxane Quaternary Ammonium Salt-19, Polysiloxane Quaternary Ammonium Salt-20, Polysiloxane Quaternary Ammonium Salt-21, Polysiloxane Quaternary Ammonium Salt-22, Polysiloxane Quaternary Ammonium Salt-24, Polysiloxane Quaternary Ammonium Salt-25, Siloxane Triol Alginate, Siloxane Triol Phytate, Organosilicon Resin, Carboxydecyl PEG-8 Sodium Dimethylsiloxane, Polydimethylsiloxane PEG-7 Sodium Acetylmethyl Taurate, Dimethylsilanol Hyaluronic Acid Sodium ester, sodium lactate methylsilanol, sodium mannuronate methylsilanol, sodium PCA methylsilanol, sodium PG-propyl polydimethylsiloxane thiosulfate copolymer, sodium PG-propyl thiosulfate polydimethylsiloxane, sodium propoxyhydroxypropyl thiosulfate silica, sorbitol silanediol, soybean triethoxysilylpropyl dimethylammonium chloride, silachlorammonium polydimethylsiloxane PEG-8 phthalate salt, stearamide propyl polydimethylsiloxane, stearyl dimethylammonium hydroxypropyl panthenol PEG-7 polydimethylsiloxane phosphate chloride, stearyl dimethylammonium hydroxypropyl PEG-7 polydimethylsiloxane phosphate chloride, stearyloxy polydimethylsiloxane, stearyloxy polymethoxysiloxane / polydimethylsiloxane copolymer, stearyl Oxytrimethylsilane, stearylaminopropyl polymethylsiloxane, stearyl polydimethylsiloxane, stearyl alcohol / lauryl methacrylate crosspolymer, stearyl polymethylsiloxane, stearyl triethoxysilane, stearyl polytrimethylsiloxane, styrene / acrylate / polydimethylsiloxane acrylate crosspolymer, styrene / acrylate / polydimethylsiloxane copolymer, polydimethylsiloxane PEG-7 phosphate TEA salt, (tetrabutoxy)propyltrisiloxane, tetramethylhexaphenyltetrasiloxane, tetramethyltetraphenyltrisiloxane, tocopheroxypropyltrisiloxane, tridecyl alcohol polyether-9PG-amino-terminated polydimethylsiloxane, triethoxyoctylsilane, polydimethylsiloxane / polymethylsiloxane copolymerTriethoxysilyl ethyl polydimethylsiloxane, Triethoxysilyl ethyl polydimethylsiloxane, Triethoxysilyl ethyl polydimethylsiloxane, Triethoxysilyl propylcarbamoylethoxypropylbutyl polydimethylsiloxane, Trifluoromethyl C1-4 alkyl polydimethylsiloxane, Trifluoropropylcyclopentasiloxane, Trifluoropropylcyclotetrasiloxane, Trifluoropropyl polydimethylsiloxane, Trifluoropropyl polydimethylsiloxane / PEG-10 crosslinked polymer, Trifluoropropyl polydimethylsiloxane / Trifluoropropyl divinyl polydimethylsiloxane crosslinked polymer, Trifluoro Propyl polydimethylsiloxane / vinyltrifluoropropyl polydimethylsiloxane / silsesquioxane crosslinked polymer, trifluoropropyl polydimethylsiloxane alcohol, trifluoropropyl dimethyl / trimethylsiloxysilicate, trifluoropropyl polymethylsiloxane, trimethoxyoctylsilane, trimethoxysilyl polydimethylsiloxane, trimethylpentaphenyltrisiloxane, trimethylsiloxyamino-terminated polydimethylsiloxane, trimethylsiloxaneoxyphenyl polydimethylsiloxane, trimethylsiloxysilicate, trimethylsiloxysilicate / polydimethylsiloxane crosslinked copolymer, trimethylsiloxysilicate / Polydimethylsiloxane crosspolymer, trimethylsiloxysilyl carbamoyl amylopectin, trimethylsilyl hydrolyzed conchiolin PG-propylmethylsilanediol crosspolymer, trimethylsilyl hydrolyzed silk PG-propylmethylsilanediol crosspolymer, trimethylsilyl hydrolyzed wheat protein PG-propylmethylsilanediol crosspolymer, trimethylsilyl amylopectin, trimethylsilanol trisilylated glycolate, trimethylsilanol trisilylated lactate, trimethylsilanol trisilylated salicylate, polytriphenyltrimethyl Siloxanes, trisiloxanes, tris(tributoxysiloxy)methylsilanes, undecene polydimethylsiloxanes, vinyl polydimethylsiloxanes, vinyl polydimethylsiloxane / lauryl polydimethylsiloxane crosspolymers, vinyl polydimethylsiloxane / polymethylsiloxane silsesquioxane crosspolymers, vinyl dimethyl / trimethylsiloxysilicate / stearyl polydimethylsiloxane crosspolymers, VP / dimethylaminoethyl methacrylate / polyurethane, carboxydecyltrisiloxane zinc and polydimethylsiloxane PEG-8 zinc succinate and mixtures thereof.

[0127] The organosilicones contained in the mixtures according to the invention are more preferably polydimethylsiloxane, cyclodimethylsiloxane, phenyltrimethylsiloxane, cyclohexylsiloxane, and cyclopentadimethylsiloxane. A detailed description of suitable volatile siloxane compounds can be found in Todd et al. in Cosm. Toil. 91, 27 (1976).

[0128] waxes and stabilizers

[0129] In addition to the natural oils used, the formulation may also contain waxes, especially natural waxes such as candelilla wax, carnauba wax, Japanese wax, escargot wax, cork wax, guaruma wax, rice bran wax, sugarcane wax, ourculry wax, lignite wax, beeswax, shellac wax, whale wax, lanolin wax, uropygial fat, (pure) ceresin, ceresin (paraffin), petroleum jelly, petroleum wax, and microwaxes; chemically modified waxes (hard waxes) such as, for example, montana ester waxes, sasol waxes, hydrogenated jojoba waxes; and synthetic waxes such as, for example, polyalkylene waxes and polyethylene glycol waxes.

[0130] Metal salts of fatty acids, such as stearic acid or magnesium ricinoleate, aluminum and / or zinc salts, can be used as stabilizers.

[0131] Main sunscreen agents

[0132] The main sunscreen agent in this invention is, for example, an organic substance (light-filtering substance) that is liquid or crystalline at room temperature, which can absorb ultraviolet radiation and release the absorbed energy, such as heat, in the form of long-wave radiation.

[0133] The formulations according to the invention advantageously contain at least one UV-A filter and / or at least one UV-B filter and / or a broadband filter and / or at least one inorganic dye. The formulations according to the invention preferably contain at least one UV-B filter or a broadband filter, more particularly at least one UV-A filter and at least one UV-B filter.

[0134] Preferred cosmetic compositions, preferably topical formulations according to the present invention, contain one, two, three, or more sunscreen agents selected from the group consisting of 4-aminobenzoic acid and its derivatives, salicylic acid derivatives, benzophenone derivatives, dibenzoylmethane derivatives, diphenyl acrylate, 3-imidazolyl-4-ylacrylic acid and its esters, benzofuran derivatives, benzyl malonate derivatives, polymeric UV absorbers containing one or more organosilicon radicals, cinnamic acid derivatives, camphor derivatives, triphenylamino-S-triazine derivatives, 2-hydroxyphenylbenzotriazole derivatives, phenylbenzimidazole sulfonic acid derivatives and their salts, menthyl anthranilate, benzotriazole derivatives, and indole derivatives.

[0135] Furthermore, it is advantageous to combine the compound of formula (I) with an active ingredient that penetrates the skin and protects skin cells from sun-induced damage from within, while reducing the level of skin matrix metalloproteinases. A preferred ingredient, a so-called aryl hydrocarbon receptor antagonist, is described in WO 2007 / 128723, which is incorporated herein by reference. Preferably, 2-benzyl-5,6-dimethoxy-3,3-dimethylindanone is preferred.

[0136] The UV filter materials cited below that can be used in this invention are preferred, but not limited to these materials.

[0137] The preferred UV filter material is selected from the group including:

[0138] para-aminobenzoic acid

[0139] • Ethoxylated (25 mol) ethyl p-aminobenzoate (INCI name: PEG-25PABA)

[0140] ·2-Ethylhexyl p-dimethylaminobenzoate

[0141] N-propoxylated (2 mol) ethyl p-aminobenzoate

[0142] • p-Aminobenzoic acid glyceride

[0143] • High-menthol salicylate (Homosalyl) (Neo) HMS)

[0144] · 2-Ethylhexyl salicylate (Neo OS)

[0145] Triethanolamine salicylate

[0146] 4-Isopropylbenzyl salicylate

[0147] • Menthol ester of anthranilate (Neo MA)

[0148] Ethyl diisopropylcinnamate

[0149] · 2-Ethylhexyl p-methoxycinnamate (Neo AV)

[0150] Methyl diisopropylcinnamate

[0151] • Isoamyl p-methoxycinnamate (Neo E 1000)

[0152] • diethanolamine p-methoxycinnamate

[0153] Isopropyl p-methoxycinnamate

[0154] ·2-Phenylenol benzimidazole sulfonic acid and salt (Neo Hydro)

[0155] ·Methyl 3-(4'-trimethylammonium)-benzylidene-camphyl-2-one sulfate

[0156] ·β-Imidazole-4(5)-Acrylic acid (uric acid)

[0157] ·3-(4'-sulfonyl)benzylidene-camphyl-2-one and its salt

[0158] ·3-(4'-Methylbenzyl)-D,L-camphor (Neo MBC)

[0159] ·3-Benzylene-D,L-Camphor

[0160] ·N-[(2 and 4)-[2-(oxoborneol-3-yl)methyl]benzyl]-acrylamide polymer

[0161] ·4,4'-[(6-[4-(1,1-dimethyl)-aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]-di-(phenylene)

[0162] 2-Ethylhexyl formate)( HEB)

[0163] • Benzyl malonate-polysiloxane ( SLX)

[0164] · Glyceryl ethylhexanoate dimethoxycinnamate

[0165] Dipropylene glycol salicylate

[0166] ·4,4',4”-(1,3,5-triazine-2,4,6-triyltriimino)-tri-benzoic acid tris(2-ethylhexyl ester) (=2,4,6-triphenylamino-(p-carbonyl-2'-ethylhexyl-1'-oxy)-1,3,5-triazine)( T150)

[0167] In the formulations according to the invention, the broadband filtering material preferably combined with one or more compounds of formula (I) is selected from the group comprising:

[0168] ·2-Cyano-3,3-diphenylacrylate-2-ethylhexyl ester (Neo 303)

[0169] ·Ethyl 2-cyano-3,3'-diphenylacrylate

[0170] ·2-Hydroxy-4-methoxybenzophenone (Neo BB)

[0171] ·2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

[0172] Dihydroxy-4-methoxybenzophenone

[0173] ·2,4-Dihydroxybenzophenone

[0174] Tetrahydroxybenzophenone

[0175] ·2,2'-Dihydroxy-4,4'-Dimethoxybenzophenone

[0176] ·2-Hydroxy-4-n-Octyloxybenzophenone

[0177] 2-Hydroxy-4-methoxy-4'-methylbenzophenone

[0178] Sodium hydroxymethoxybenzophenone sulfonate

[0179] Disodium 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfo-benzophenone

[0180] Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3(1,3,3,3-tetramethyl-1-(trimethylsilane))

[0181] (-O)-dimethsiloxy)-propyl) XL)

[0182] ·2,2 ′ -methylene-di-(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)-phenol)( M)

[0183] ·2,4-Di-[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-1,3,5-triazine

[0184] ·2,4-Di-[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine ( S)·2,4-Di-[{(4-(3-sulfonic acid)-2-hydroxypropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine sodium salt·2,4-Di-[{(3-(2-propoxy)-2-hydroxypropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine

[0185] · 2,4 - bis - [{4 - (2 - ethylhexyloxy) - 2 - hydroxy}phenyl] - 6 - [4 - (2 - methoxyethylcarbonyl)phenylamino] - 1,3,5 - triazine · 2,4 - bis - [{4 - (3 - (2 - propoxy) - 2 - hydroxypropoxy) - 2 - hydroxy}phenyl] - 6 - [4 - (2 - ethylcarbonyl)phenylamino] - 1,3,5 - triazine

[0186] · 2,4 - bis - [{4 - (2 - ethylhexyloxy) - 2 - hydroxy}phenyl] - 6 - (1 - methylpyrrol - 2 - yl) - 1,3,5 - triazine

[0187] · 2,4 - bis - [{4 - tris - (trimethylsilyloxymethylsilylpropoxy) - 2 - hydroxy}phenyl] - 6 - (4 - methoxyphenyl) - 1,3,5 - triazine

[0188] · 2,4 - bis - [{4 - (2 ″ - methylpropoxyenyl) - 2 - hydroxy}phenyl] - 6 - (4 - methoxyphenyl) - 1,3,5 - triazine

[0189] · 2,4 - bis - [{4 - (1 ′ ,1 ′ ,1 ′ ,3 ′ ,5 ′ ,5 ′ ,5 ′ - heptamethylsilyloxy - 2 ″ - methylpropoxy) - 2 - hydroxy}phenyl] - 6 - (4 - methoxyphenyl) - 1,3,5 - triazine

[0190] The composition may contain other typical cleaning and washing composition ingredients such as UV - A filtering substances, which are preferably combined with one or more compounds of formula (I) in the preparation according to the invention and are selected from the group including

[0191] · 4 - isopropyldibenzoylmethane

[0192] · p - phenylenedimethylene - dicyclohexanesulfonic acid and salts ( SX)

[0193] · 4 - tert - butyl - 4 ′ - methoxydibenzoylmethane (avobenzone) / (Neo 357)

[0194] · phenyl - di - benzimidazolyl - tetrasulfonic acid disodium salt (Neo AP)

[0195] · 2,2 ′ -(1,4 - phenylene) - bis - (1H - benzimidazole - 4,6 - disulfonic acid), monosodium salt

[0196] ·2-(4-Diethylamino-2-hydroxybenzoyl)-hexyl benzoate ( A Plus)

[0197] • Indane subunit compounds according to DE 100 55 940A1 (=WO 2002038537)

[0198] The composition may contain other typical cleaning and washing composition components such as UV filter materials, which are preferably combined with one or more compounds of formula (I) and selected from the group comprising, in the formulation according to the invention.

[0199] para-aminobenzoic acid

[0200] ·Methyl 3-(4'-trimethylammonium)-benzylidene camphene-2-one sulfate

[0201] • High-menthol salicylic acid ester (Neo HMS)

[0202] ·2-Hydroxy-4-methoxybenzophenone (Neo BB)

[0203] ·2-Phenylenimazole sulfonic acid (Neo Hydro)

[0204] • Terephthalimide-dicamphenesulfonic acid and its salt ( SX)

[0205] ·4-tert-butyl-4'-methoxydibenzoylmethane (Neo 357)

[0206] ·3-(4'-sulfonyl)benzylidene-camphyl-2-one and its salt

[0207] ·2-Cyano-3,3-diphenylacrylate-2-ethylhexyl ester (Neo 303)

[0208] ·N-[(2 and 4)-[2-(oxoborneol-3-yl)methyl]benzyl]-acrylamide polymer

[0209] · 2-Ethylhexyl p-methoxycinnamate (Neo AV)

[0210] • Ethoxylated (25 mol) ethyl p-aminobenzoate (INCI name: PEG-25PABA)

[0211] • Isoamyl p-methoxycinnamate (Neo E1000)

[0212] ·2,4,6-Triphenylamino-(p-carbonyl-2'-ethylhexyl-1'-oxy)-1,3,5-triazine ( T150)

[0213] Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3(1,3,3,3-tetramethyl-1-(trimethylsilane))

[0214] (-O)-dimethsiloxy)-propyl) XL)

[0215] ·4,4'-[(6-[4-(1,1-dimethyl)-aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]-di-(phenylene)

[0216] 2-Ethylhexyl formate (Uvasorb HEB)

[0217] ·3-(4'-Methylbenzyl)-D,L-camphor (Neo MBC)

[0218] ·3-Benzylene-camphor

[0219] · 2-Ethylhexyl salicylate (Neo OS)

[0220] ·2-Ethylhexyl 4-dimethylaminobenzoate (Padimate O)

[0221] • Hydroxy-4-methoxybenzophenone-5-sulfonic acid and its sodium salt

[0222] ·2,2'-Methylene-bis-(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)-phenol)( M)·Neophenylene di-benzimidazolyl tetrasulfonic acid disodium salt (Neo AP)

[0223] ·2,4-Di-[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine ( S)·Benzyl malonate-polysiloxane ( SLX)

[0224] • Menthol ester of anthranilate (Neo MA)

[0225] ·2-(4-Diethylamino-2-hydroxybenzoyl)-hexyl benzoate ( A Plus)

[0226] • Indane subunit compounds according to DE 100 55 940 (=WO 02 / 38537).

[0227] Advantageous primary and secondary sunscreen agents are described in WO 2005 123101A1. Advantageously, these formulations contain at least one UVA filter and / or at least one UVB filter and / or at least one inorganic pigment. The formulations in this invention can be present in various forms, such as those commonly used in sunscreen formulations. Therefore, they can be in the form of solutions, water-in-oil (W / O) or oil-in-water (O / W) emulsions or multiple emulsions, such as water-in-oil-in-water (W / O / W) emulsions, gels, aqueous dispersions, solid rods, or aerosols.

[0228] In another preferred embodiment, the formulation of the present invention contains a light-blocking agent, specifically, the total amount of UV-filtering material and / or inorganic pigment (UV-filtering pigment) is sufficient to give the formulation of the present invention a light protection factor greater than or equal to 2 (preferably greater than or equal to 5). This formulation of the present invention is particularly suitable for protecting skin and hair.

[0229] Secondary sunscreen

[0230] In addition to the main sunscreen groups mentioned above, secondary sunscreens with antioxidants can also be used. Antioxidant-based secondary sunscreens block the photochemical reaction chain that occurs when ultraviolet rays penetrate the skin. Typical examples include amino acids (e.g., glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g., uric acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g., anserine), carotenoids, carotenoids (e.g., α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g., dihydrolipoic acid), aurora thioglycosides, propylthiouracil, and other thiols (e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and its glycosyl, N-acetyl, methyl groups, etc.). Ethyl, propyl, pentyl, butyl, lauryl, palmitoyl, oleylenyl, α-linoleyl, cholesterol, and their glycerides) and their salts, dilaurate thiodipropionate, dioctadecyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides, and salts), and sulfonylimine compounds with very low resistance doses (e.g., sulfonyl butyrate, sulfocysteine, sulfonyl butyrate, pentyl, hexa-, and hepta-thionine sulfonylimine), as well as (metal) chelating agents (e.g., α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids Characteristic compounds (e.g., citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g., linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and panthenol and their derivatives, vitamin C and its derivatives (e.g., ascorbate palmitate, ascorbate magnesium phosphate, ascorbate acetate), tocopherol and its derivatives (e.g., vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), as well as benzoic acid resins such as benzoyl benzoate, rutin and its derivatives, glycosylrutin, ferulic acid, and fenestrations. Sorbitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiacol, lignan, trihydroxybutyrylbenzene, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, titanium dioxide (e.g., dispersions in ethanol), zinc and its derivatives (e.g., ZnO, ZnSO4), selenium and its derivatives (e.g., selenomethionine), stilbenes and their derivatives (e.g., stilbene oxide, trans-stilbene oxide), and derivatives of these active compounds suitable for the purposes of this invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides, and lipids).

[0231] Advantageous inorganic secondary photoprotective pigments are finely dispersed metal oxides and metal salts, which are also mentioned in WO2005 123101A1. In the finished cosmetic formulations according to the invention, the total amount of inorganic pigments, particularly hydrophobic inorganic micropigments, is advantageously 0.1 to 30% by weight, preferably 0.5 to 10.0% by weight, based on the total weight of the formulation in each case.

[0232] Also preferred are particulate UV filters or inorganic pigments, which may optionally be hydrophobic and may be oxides of, for example, titanium (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium (e.g., Ce2O3) and / or mixtures thereof.

[0233] anti-inflammatory agents

[0234] Suitable anti-inflammatory agents particularly include corticosteroids, such as hydrocortisone, dexamethasone, dexamethasone phosphate, methyldehydrocortisone, or cortisone, which can be advantageously used as anti-inflammatory active ingredients or active ingredients to relieve redness and itching. This list can be expanded by adding other steroidal anti-inflammatory drugs. Nonsteroidal anti-inflammatory drugs (NSAIDs) can also be used. More specifically:

[0235] (i) Corticosteroid anti-inflammatory substances, especially hydrocortisone, hydrocortisone derivatives such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone,

[0236] (ii) Nonsteroidal anti-inflammatory drugs (NSAIDs), especially oxacins such as piroxicam or tenoxacin, salicylates such as aspirin, disalicylate, solprin or fendusal, acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tomatine or clindanac, methyl esters such as mefenamic acid, meclofenamic acid, flufenamic acid or niflufenic acid, propionic acid derivatives such as ibuprofen, methoxynaphthylpropionic acid or benzoxalofen, and pyrazoles such as...

[0237] Phenylacetylbutazone, hydroxyphenylbutazone, febrazone, or azathioprine

[0238] (iii) Natural or naturally occurring anti-inflammatory substances or substances that relieve redness and / or itching, especially extracts or fractions of chamomile, aloe vera, myrrh, madder, willow, willow grass, oats, calendula, arnica, St. John's wort, honeysuckle, rosemary, passionflower (Passiflora incarnata), witch hazel, ginger, or purple daisy, or their single components.

[0239] An active compound,

[0240] (iv) Histamine receptor antagonists, serine protease inhibitors (e.g., soybean extract), TRPV1 antagonists (e.g.)

[0241] Examples include 4-tert-butylcyclohexanol, NK1 antagonists (e.g., aprepitant, hydroxyphenylpropionamide benzoic acid), cannabinoid receptor agonists (e.g., palmitoylethanolamine), and TRPV3 antagonists.

[0242] Examples cited herein include oxacins such as piroxicam or tenoxacin; salicylates such as aspirin, disalcid, solprin, or fendusal; acetic acid derivatives such as diclofenac, clofenac, indomethacin, sulindac, tometidine, or clindanac; methyl esters such as mefenamic acid, meclofenamic acid, flufenamic acid, or niflufenac; propionic acid derivatives such as ibuprofen, naproxen, benzylprofen; or pyrazoles such as phenylbutazone, hydroxypropyl methylphenidate, febrazone, or azaprozin. Anthranilic acid derivatives, particularly avenanthramides described in WO 2004047833A1, are preferred components in the compositions of this invention.

[0243] Also useful are mixtures of natural or naturally occurring anti-inflammatory substances or mixtures of the following substances, such as α-bisabolol, apigenin, apigenin-7-glucoside, gingerols, shogaols, gingerenes, gingerols, dehydroshogacones, paradols, natural or naturally occurring amaranthramides, preferably tranilast, amaranthramide A, amaranthramide B, amaranthramide C, and non-natural or non-naturally occurring amaranthramides, preferably dihydroamaranthramide D, dihydroamaranthramide E, amaranthramide D, amaranthramide E, amaranthramide F, boswellic acid, phytosterols, glycyrrhizin, glycyrrhizin, and glycyrrhizin. Chalcone A; preferably, selected from the group comprising α-bisabolol, natural avemental amide, non-natural avemental amide, preferably dihydroavemental amide D (as described in WO2004047833A1) and / or allantoin, panthenol, lanolin, (pseudo-)ceramides [preferably ceramide 2, hydroxypropyl bispalmitamide MEA, hexadecyloxypropylglyceromethoxypropyltetradecanoamide, N-(1-hexadecyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethylpalmitoyloxyhydroxypropylpalmitamide], glycosphingolipids, phytosterols, chitosan, mannose, lactose and β-glucan, especially 1,3-1,4-β-glucan from oats.

[0244] When bisabolol is used in this invention, it can be a natural or synthetic source, and α-bisabolol is preferred. Preferably, the bisabolol used is synthesized or is a synthetic mixture of natural (-)-α-bisabolol and / or α-bisabolol isomers. If natural (-)-α-bisabolol is used, it can be used as a component of essential oils or plant extracts or their fractions, for example, as a component of oils or extracts (fractions) of chamomile or vanillosmopsis (especially vanillosmopsis erythropappa or vanillosmopsis arborea). Synthetic α-bisabolol can be obtained, for example, from the Symrise name "Dragosantol".

[0245] If ginger extract is used in this invention, fresh or dried ginger root extract is preferred, which is prepared by extraction using methanol, ethanol, isopropanol, acetone, ethyl acetate, carbon dioxide (CO2), hexane, dichloromethane, chloroform, or other solvents or mixtures of solvents of similar polarity. The extract is characterized by the presence of components that reduce skin irritation, such as gingerol, shogaol, ginger glycol, dehydroshogazone, and / or paradols.

[0246] physiological cooling agent

[0247] The composition may also contain one or more substances (cooling agents) with physiological cooling effects, preferably from the following list: menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, isomenthol, neoisomenthol, neomenthol), menthyl ethers (e.g., (I-menthoxy)-1,2-propanediol, (I-menthoxy)-2-methyl-1,2-propanediol, I-menthyl-methyl ether), menthyl esters (e.g., menthyl formate, menthyl acetate, menthyl isobutyrate, menthyl lactate, L-lactic acid, D-menthyl ester ... - L-menthyl lactate, (2-methoxy)-menthyl acetate, (2-methoxyethoxy)-menthyl acetate, pyroglutamic acid menthyl), menthyl carbonate (e.g., propylene glycol menthyl carbonate, ethylene glycol menthyl carbonate, glyceryl menthyl carbonate or mixtures thereof), half-esters of menthol with dicarboxylic acids or their derivatives (e.g., menthyl succinate, menthyl glutarate, menthyl malonic acid, O-menthyl succinate-N,N-(dimethyl)amide, O-menthyl succinate amide), menthyl carboxylic acid amide (preferably such as US in this case). Menthane carboxylic acid-N-acetamide [WS3] or Nα-(menthane carbonyl) glycine ethyl ester [WS5] as described in WO2005049553A1, menthane carboxylic acid-N-(4-cyanophenyl)amide or menthane carboxylic acid-N-(4-cyanomethylphenyl)amide, methane carboxylic acid-N-(alkoxyalkyl)amides, menthone and menthone derivatives (e.g., L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyric acid-N-formamide [WS23]), isoprene alcohol or its esters (I-(-)-isomenthane alcohol, I-(-)-isomenthane alcohol). Formamides include: phenoxyacetic acid esters, menthol derivatives (e.g., p-menthol-3,8-diol), piperazine alcohol or synthetic or natural mixtures containing piperazine alcohol, pyrrolidone derivatives of cycloalkyl diones (e.g., 3-methyl-2(1-pyrrolyl)-2-cyclopenten-1-one) or tetrahydropyrimidin-2-one (e.g., iciline or related compounds described in WO2004 / 026840), other formamides (e.g., N-(2-(pyridin-2-yl)ethyl)-3-p-menthol formamide or related compounds), (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-isopropyl)cyclohexane-formamide [WS12], and oxaloacetic acid esters (preferably described in EP 2033688A2).

[0248] antimicrobial agents

[0249] A suitable antimicrobial agent is theoretically any substance capable of resisting Gram-positive bacteria, such as 4-hydroxybenzoic acid and its salts and esters, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan), 4-chloro-3,5-dimethylphenol, 2,2'-methylenebis(6-bromo-4-chlorophenol), 3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4-chlorophenol, 3-( 4-Chlorophenoxy)-1,2-propanediol, butyl 3-iodo-2-propynylcarbamate, chlorhexidine, 3,4,4'-trichlorocarbamate (TTC), antibacterial fragrance, thymol, thymol oil, eugenol, clove oil, menthol, peppermint oil, farnesol, phenoxyethanol, glyceryl monodecanoate, glyceryl monocaprylate, glyceryl monolaurate (GML), diglyceryl monodecanoate (DMC), N-alkylamine salicylate, such as n-octylsalicylate or n-decylsalicylate.

[0250] preservative

[0251] Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentylene glycol or sorbic acid, and other classes of compounds listed in Annex 6, Parts A and B of the Cosmetics Directive.

[0252] preparation

[0253] The preferred compositions according to the invention are selected from products for treating, protecting, caring for and cleansing skin and / or hair, or as cosmetic products, preferably as leave-on products (meaning that one or more compounds of formula (I) remain on the skin and / or hair for a longer time than rinse-off products, thus making their moisturizing and / or anti-aging and / or wound-healing effects more pronounced).

[0254] The formulations of the present invention are preferably in the form of emulsions, such as W / O (water-in-oil), O / W (oil-in-water), W / O / W (oil-in-water), O / W / O (oil-in-water-in-oil), PIT emulsions, Pickling emulsions, low-oil-content emulsions, microemulsions or nanoemulsions, solutions, such as solutions in oils (fatty oils or fatty acid esters, especially C6-C32 fatty acid C2-C30 esters) or silicone oils, dispersions, suspensions, creams, emulsions or milks, depending on the preparation method and ingredients, gels (including hydrogels, aqueous dispersions, oleogels), sprays (e.g., pump sprays or sprays containing propellants) or foams or impregnation solutions for wiping cosmetics, detergents, such as soaps, synthetic detergents, washes, shower and bath formulations, bath products (capsules, oils, tablets, salts, bath salts, soaps, etc.); effervescent formulations, skin care products such as emulsions (as described above), ointments, pastes Agents, gels (as described above), oils, sesame oils, whey, powders (such as face powder, body powder), perfumes, eau de toilette, aftershave, face masks, eyebrow pencils, lipsticks, roll-ons, pump dispensers, aerosols (foaming, non-foaming, or post-foaming), deodorants and / or antiperspirants, mouthwash and oral cleansers, foot care products (including exfoliants and deodorants), insect repellents, sunscreens, after-sun products, shaving products, aftershave creams, pre- and post-shave washes, depilatory agents, hair care products Products such as shampoos (including 2-in-1 shampoos, anti-dandruff shampoos, baby shampoos, dry hair shampoos, concentrated shampoos), conditioners, hair growth oils, hair growth solutions, hair dyes, styling creams, hair oils, perming and curling solutions, hair gels, styling aids (such as gels or waxes), hair smoothing agents (conditioners, relaxants), hair dyes such as short-term direct hair dyes, semi-permanent hair dyes, permanent hair dyes, conditioners, hair mousses, eye care products, cosmetics, makeup removers, or baby products.

[0255] The formulations according to the invention are particularly preferred in emulsion form, especially W / O, O / W, W / O / W, O / W / O emulsions, PIT emulsions, Pickering emulsions, low-oil-content emulsions, microemulsions or nanoemulsions, gels (including hydrogels, aqueous dispersions, oleogels), solutions, such as solutions in oils (fatty oils or fatty acid esters, especially C6-C32 fatty acid C2-C30 esters) or silicone oils, or aerosols (e.g., pump-jet aerosols or aerosols containing propellants).

[0256] The content of excipients and additives can be 5 to 99% by weight, preferably 10 to 80% by weight, based on the total weight of the formulation. Those skilled in the art can readily determine the amount of cosmetic or dermatological adjuvants and additives, as well as fragrances, used in each case through simple, iterative testing, depending on the nature of the specific product.

[0257] The formulation may also contain up to 99% by weight, preferably 5 to 80% by weight, of water, based on the total weight of the formulation.

[0258] Industrial applications

[0259] Another object of the present invention relates to a non-therapeutic cosmetic method for whitening human skin, comprising or consisting of the following steps:

[0260] (a) Provide an agonist as defined above, optionally dissolved in a pharmaceutically acceptable carrier.

[0261] (b) Applying agonists or compositions containing them topically to the skin of an individual.

[0262] Finally, this invention covers the use of agonists as defined above for the whitening of human skin.

[0263] Finally, the present invention also relates to the use of the olfactory receptor agonist as a cosmetic ingredient. For the sake of good order, it is emphasized that all preferred embodiments, scopes, combinations, and compositions described above are also valid for the claimed industrial applications. Therefore, any repetition is redundant.

[0264] Examples 1 to 24

[0265] Tyrosinase is an oxidase that is the rate-limiting enzyme controlling melanin production. This enzyme is primarily involved in two different reactions in melanin synthesis: first, the hydroxylation of monophenols; and second, the conversion of ortho-diphenols to their corresponding ortho-quinones. The ortho-quinones undergo various reactions to ultimately form melanin. Tyrosinase is a copper-containing enzyme found in plant and animal tissues that catalyzes the oxidation of tyrosine to produce melanin and other pigments. It is present in melanosomes synthesized by melanocytes in the skin. In humans, tyrosinase is encoded by the TYR gene.

[0266] To measure cellular tyrosinase activity, B16 cells treated with several doses of the compound for 3 days were lysed by incubation at 4°C for 30 min in a lysis buffer containing a mixture of protease inhibitors (20 mM sodium phosphate, pH 6.8, 1% Triton X-100, 1 mM PMSF, 1 mM EDTA). The lysates were centrifuged at 15,000 × g for 10 min to obtain the supernatant as a source of tyrosinase. The reaction mixture contained 20 mM phosphate buffer, pH 6.8, and 1.25 mM L-DOPA (Sigma-Aldrich). After incubation at 37°C for 2 hours, dopachrome formation was monitored by measuring absorbance at 475 nm using a TECAN microplate reader. Kojic acid was used as a positive control. The results are shown in Table 1.

[0267] Table 1. Effects of the test substances on tyrosinase activity in B16 melanoma cells.

[0268]

[0269]

Claims

1. Use of an olfactory receptor agonist exhibiting (i) a molecular weight of 50 to 300 Dalton and (ii) an evaporation rate relative to butyl acetate of 3 to 15, for the manufacture of a medicament for the prevention and / or treatment of hyperpigmentation of human skin, wherein the agonist is selected from the group comprising C12 aldehyde; allyl phenoxyacetate; benzylacetone; carvone (2,4,4,7-tetramethyloct-6-en-3-one, CAS-No. 74338-72-0); cyclogalbanate; cyclohexylmagnol; 8-cyclohexadecen-1-one ((cis / trans) cyclohexadec-8-en-1-one, CAS-No. 3100-36-5); 3,3,5-trimethylcyclohexyl acetate (acetic acid homopinol, CAS-No. 67859-96-5); benzaldehyde dimethyl acetal; 4-(3-methylbutyl)cyclohexan-1-ol (CAS-No. 830322-14-0); and mixtures thereof.

2. Use according to claim 1, wherein the agonist exhibits a molecular weight of 75 to 200 Dalton.

3. Use according to claim 1, wherein the agonist exhibits an evaporation rate of 5 to 10.

4. Use according to claim 1, wherein the agonist is applied in a concentration of 0.1 to 100 pg / ml.

5. Use according to claim 1, wherein the agonist is applied in a concentration of 0.5 to 10 pg / ml.

6. Use of an olfactory receptor agonist as described in claim 1 for the manufacture of a cosmetic or pharmaceutical composition for the prevention and / or treatment of hyperpigmentation of human skin.

7. Use according to claim 6, wherein the composition is a lotion, cream, emulsion or ointment.

8. Use according to claim 6, wherein the composition further comprises a cosmetically or pharmaceutically acceptable carrier.

9. Use according to claim 8, wherein the carrier is selected from the group comprising water, ethanol, isopropanol, butanol, glycerol, ethylene glycol, propylene glycol and diethylene glycol or mixtures thereof.

10. Use according to claim 6, wherein the composition further comprises at least one biological agent, antioxidant and / or skin lightening agent.

11. Use according to claim 10, wherein the biological agent or antioxidant is selected from the group comprising tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, ribonucleic acid, deoxyribonucleic acid and fragmented products thereof, beta-glucan, retinol, bisabalol, allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides, pseudoceramides, essential oils, plant extracts, vitamin complexes, amino acids, peptides and mixtures thereof.

12. Use according to claim 10, wherein the skin lightening agent is selected from the group comprising kojic acid and resorcinols.

13. A non-therapeutic cosmetic method for lightening human skin, comprising or consisting of the following steps: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ (a) providing an olfactory receptor agonist as described in claim 1, optionally dissolved in a pharmaceutically acceptable carrier, (b) topically applying said agonist or a composition comprising the same to the skin.

14. Non-therapeutic use of an olfactory receptor agonist as described in claim 1 for lightening the skin.

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