Choline amino acid ionic liquid microemulsions, their preparation methods and applications

CN116983261BActive Publication Date: 2026-05-26NORTHEASTERN UNIV CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHEASTERN UNIV CHINA
Filing Date
2023-08-02
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing ionic liquid microemulsions exhibit high biotoxicity and lack antibacterial activity in transdermal drug delivery, limiting their application in the pharmaceutical field.

Method used

An oil-in-oil ionic liquid choline amino acid ionic liquid microemulsion was prepared by reacting amino acids with choline in water or ethanol, adding the surfactant isopropyl myristate and the mixed surfactants Tween-80 and Span-20 to form a stable microemulsion system with good biocompatibility and antibacterial activity.

Benefits of technology

It achieves highly efficient transdermal drug delivery, significantly increases drug solubility, possesses strong antibacterial ability, and maintains good biocompatibility, making it suitable for transdermal drug delivery.

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Abstract

This invention relates to choline amino acid ionic liquid microemulsions, their preparation methods, and applications. It belongs to the fields of ionic liquid microemulsions and pharmaceutical formulations. The preparation method includes: dissolving amino acids and choline in water or ethanol, mixing them under heating with shaking, removing the solvent by rotary evaporation, filtering unreacted amino acids to obtain a choline amino acid ionic liquid; mixing a surfactant with isopropyl myristate in a specific ratio, adding the ionic liquid dropwise to the mixture while continuously stirring until the liquid becomes clear and transparent. The choline amino acid ionic liquid microemulsion provided by this invention has good transdermal absorption capacity and can significantly increase drug solubility. Compared to water, it increases the solubility of hydrophobic methotrexate by 3.2–10.5 times and the solubility of doxorubicin hydrochloride by 1.3–2 times. It also has strong inhibitory and bactericidal effects against Staphylococcus aureus, good biocompatibility, and can be used as a carrier for transdermal drug delivery.
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