A Chinese medicine composition with marrow-opening and rehabilitation effects, and its preparation method and application

Abstract

The present invention discloses a Chinese medicine composition with a marrow-opening and rehabilitation effect, and the Chinese medicine composition is made of the following raw materials: red ginseng, astragalus, angelica, salvia miltiorrhiza, chuanxiong, white peony, Poria, Atractylodes macrocephala, Eucommia ulmoides, Cistanche deserticola, Morinda officinalis, Rhizoma Achyranthis Bidentatae, Carthamus tinctorius, Radix Dipsaci, Radix Notoginseng, Radix Puerariae, Citron, Cardamom, Acorus calamus, Rhizoma Alismatis, Semen Sinapis, Fructus Corni, Ophiopogon japonicus, Radix Rehmanniae, Lilium, Fructus Lycii, dried ginger, red dates, and Radix Glycyrrhizae Preparata. The present invention also provides a preparation method and use of the Chinese medicine composition. The Chinese medicine composition of the present invention has an excellent marrow-opening and rehabilitation effect, can effectively prevent, alleviate and / or treat, and rehabilitate spinal strain degenerative lesions, and improve the quality of life and function of patients as a whole, improve physical fitness, and enhance resistance.

Description

Technical Field

[0001] The present invention relates to the technical field of medicine and health care, and in particular to a Chinese medicine composition with marrow-opening and rehabilitation effects, and a preparation method and application thereof. Background Art

[0002] According to the principles and laws of life science and the holistic concept of traditional Chinese medicine, the formation and occurrence of a certain disease in the human body (except for traumatic diseases) is not independent and single, and there will be related overall damage and manifestations, as well as the long-term impact of early spinal strain degeneration. Therefore, conventional medication, syndrome differentiation and medication for a certain main symptom, can only improve symptoms to a limited extent, and it is difficult to achieve overall improvement and continuous recovery from the root.

[0003] The spine is the most load-bearing part of the human body. The human body cannot stand, sit or walk without the support of the spine. Due to different understandings of the disease, people generally believe that the main symptoms of spinal osteoarthritis are caused by trauma, cold and dampness and other pathogenic factors that aggravate the strain and degeneration of the spine, causing cervical and lumbar spondylosis, intervertebral disc herniation, etc., which cause pain, limited movement, and involve neck, shoulder, arm, waist and leg pain. Treatment is mainly to improve and relieve symptoms, but it is difficult to control the degenerative lesions of the spine, the progressive development and aggravation of the damage of fibrosis and adhesion of related bones and joints, and the formation of related diseases.

[0004] In fact, the spine is most susceptible to strain and degeneration. The surrounding nerves and blood vessels are compressed, causing damage to the tissue cells of the related skin, flesh, bones, internal organs, and gradually forming degenerative lesions and malignant changes, causing various sub-health, three highs, obesity, metabolic syndrome, hypertension, diabetes and other chronic diseases, difficult diseases, cardiovascular and cerebrovascular diseases, tumors and other diseases.

[0005] For example, for sudden tinnitus and deafness, the conventional treatment is to receive intravenous infusion and hyperbaric oxygen in the ENT department of the hospital. However, some patients have not seen any effect after repeated treatment for two weeks to a month or even longer, and cannot be cured by taking Chinese medicine or acupuncture. The reason why some tinnitus and deafness cannot be cured is that it is related to the poor overall condition of the whole body, long-term strain and degeneration of the spine, insufficient blood supply to the heart and brain, and dysfunction of the internal organs. Therefore, these patients are accompanied by dizziness, palpitations, chest tightness, irritability, poor sleep, decreased energy and physical strength, forgetfulness, or other symptoms, such as neck and waist pain, fever in the head and face, sweating, cold legs, etc. The general conventional traditional dialectical medication only targets the main symptoms of tinnitus and deafness and a series of related symptoms, which will inevitably fail to cure them.

[0006] At present, there are no Chinese patent medicines in clinical practice that have the effect of marrow rehabilitation, such as spinal rehabilitation, cardiopulmonary rehabilitation, cardio-cerebral rehabilitation, and bone injury rehabilitation. They are all aimed at improving a series of symptoms in a certain local lesion site, with the purpose of relieving and improving symptoms.

[0007] 1. Background of Chinese patent medicine for spinal rehabilitation

[0008] For example, Jingfukang granules, the main ingredients are Chuanxiong, Atractylodes, White Peony, Safflower, Astragalus, Semen Cassiae, Phellodendron, etc. The main function is to promote blood circulation and dredge collaterals, dispel wind and relieve pain. It is used for cervical spondylosis caused by rheumatism and blood stasis, and relieves symptoms such as dizziness, stiff neck, shoulder and back pain, and numbness of arms. However, these are only temporary improvements in symptoms. When taking Jingfukang, it is necessary to combine the specific symptoms and take it under the guidance of a professional doctor. It is not recommended to use it privately on a daily basis.

[0009] For example, Qiangyao Jianshen Pills, the main ingredients are Cibotium barometz, Black Tiger, Tripterygium wilfordii, Morus alba (steamed), Millettia reticulata, Golden Rosacea, Ligustrum lucidum (steamed), Rhizoma Cynoglossi, Cuscuta australis, and Cuscuta australis (made with salt water), and the auxiliary materials are sucrose and talcum powder. It has the effects of strengthening the waist and kidney, dispelling wind and activating collaterals. It is used for kidney deficiency and low back pain, weak knees, neurasthenia, frequent urination, rheumatic bone pain, and is suitable for relieving symptoms such as low back pain and arthritis. However, these are only temporary improvements in symptoms. It is important to note that if the symptoms do not improve after taking the medicine for two weeks or during the medication period, or if the symptoms worsen, or if new serious symptoms appear, the medicine should be stopped immediately and go to the hospital for treatment.

[0010] 2. The same is true for Chinese patent medicines for cardiopulmonary, cardiocerebral rehabilitation, and (bone injury rehabilitation)

[0011] For example, the main ingredients of Bufei Pills are Rehmannia glutinosa, Codonopsis pilosula, Astragalus membranaceus, Morus alba bark, Aster tataricus, Schisandra chinensis, and the auxiliary ingredient is honey. From its ingredients, we can see that its main function is to nourish the lungs and replenish qi, relieve cough and relieve asthma, so it can only be used clinically for some lung qi deficiency, shortness of breath, cough and asthma, dry cough and sticky sputum, dry throat and tongue, etc. It has the effects of nourishing the lungs and replenishing qi, relieving cough and relieving asthma, but it can only temporarily improve symptoms, and the sustained recovery effect is limited.

[0012] For example, Bawei Qingxin Chenxiang Powder is a heat-clearing agent, which contains ingredients such as agarwood, safflower, and rhubarb. It has the effects of regulating qi, calming the mind, and clearing the heart and lungs. This medicine can only treat discomfort such as excessive heart and lung fire, chest tightness, palpitations and shortness of breath, and it is also a temporary improvement of symptoms.

[0013] Overall, the above-mentioned Chinese patent medicines have failed to improve the overall functions of the human body, truly improve the body's metabolism, promote cell detoxification, regeneration and repair, and improve the quality of life and function of the human body. Therefore, it is generally difficult to achieve long-term stable control and recovery effects of the disease. Summary of the invention

[0014] In view of the above problems, the purpose of the present invention is to provide a Chinese medicine composition with marrow-opening and rehabilitation effects, as well as a preparation method and application thereof, to fundamentally repair spinal strain and degenerative lesions, and to enhance local rehabilitation effects by promoting the overall health of patients.

[0015] In one aspect, the present invention provides a Chinese medicine composition having a marrow-opening and rehabilitation effect, wherein the Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0016] 3-20 parts of red ginseng, 10-50 parts of astragalus, 5-30 parts of angelica, 5-30 parts of salvia, 5-30 parts of chuanxiong, 5-30 parts of white peony, 5-30 parts of tuckahoe, 5-30 parts of atractylodes, 5-20 parts of eucommia, 3-20 parts of cistanche, 3-20 parts of morinda officinalis, 5-20 parts of oxalis, 5-30 parts of safflower, 5-30 parts of chuanxiong, 3-15 parts of panax notoginseng, 5-30 parts of Pueraria root, 5-15 parts of bergamot, 5-15 parts of citron, 5-15 parts of cardamom, 5-30 parts of calamus, 5-30 parts of oriental rhizome, 5-15 parts of white mustard seeds, 5-30 parts of cornus officinalis, 5-20 parts of ophiopogon, 5-20 parts of rehmannia, 5-20 parts of lily, 5-30 parts of wolfberry, 5-20 parts of dried ginger, 5-30 parts of red dates, and 5-20 parts of roasted liquorice.

[0017] Optionally, the Chinese medicine composition is made from the following raw materials in parts by weight:

[0018] 5-10 parts of red ginseng, 25-35 parts of astragalus, 7-15 parts of angelica, 10-20 parts of salvia, 10-20 parts of chuanxiong, 10-20 parts of white peony, 10-20 parts of tuckahoe, 7-15 parts of atractylodes, 7-15 parts of eucommia, 3-10 parts of cistanche, 3-10 parts of morinda officinalis, 7-15 parts of oxalis, 7-15 parts of safflower, 10-20 parts of chuanxiong, 7-15 parts of panax notoginseng, 10-20 parts of Pueraria root, 7-12 parts of bergamot, 7-12 parts of citron, 7-12 parts of cardamom, 10-20 parts of calamus, 10-20 parts of oriental rhizome, 7-12 parts of white mustard seeds, 10-20 parts of cornus officinalis, 5-10 parts of ophiopogon, 5-10 parts of rehmannia, 5-10 parts of lily, 7-15 parts of wolfberry, 7-15 parts of dried ginger, 10-20 parts of red dates, and 7-15 parts of roasted liquorice.

[0019] Optionally, the Chinese medicine composition is made from the following raw materials in parts by weight:

[0020] 7 parts of red ginseng, 30 parts of astragalus, 10 parts of angelica, 15 parts of salvia miltiorrhiza, 10 parts of chuanxiong, 15 parts of white peony root, 15 parts of tuckahoe, 10 parts of atractylodes, 10 parts of eucommia, 5 parts of cistanche, 5 parts of morinda officinalis, 10 parts of oxalis, 10 parts of safflower, 15 parts of chuanxiong, 10 parts of notoginseng, 15 parts of kudzu root, 10 parts of citron, 10 parts of cardamom, 15 parts of calamus, 15 parts of oriental rhizome, 10 parts of white mustard seeds, 15 parts of cornus officinalis, 7 parts of ophiopogon, 7 parts of rehmannia, 10 parts of lily, 10 parts of wolfberry, 10 parts of dried ginger, 15 parts of red dates, and 10 parts of roasted liquorice.

[0021] Optionally, the Chinese medicine composition is in oral dosage form.

[0022] Optionally, the oral dosage form is a pill, tablet, capsule, granule, powder or oral solution.

[0023] In another aspect, the present invention provides a method for preparing a Chinese medicine composition, comprising:

[0024] The raw materials are pulverized separately and then mixed, or the raw materials are mixed and then pulverized to obtain a mixture;

[0025] Alternatively, the raw materials are mixed and then extracted to obtain an extract.

[0026] Optionally, the preparation method further comprises:

[0027] The mixture or the extract is added with pharmaceutically acceptable excipients to prepare an oral dosage form.

[0028] On the other hand, the present invention provides the use of the Chinese medicine composition in the preparation of a medicament for preventing, alleviating and / or treating degenerative lesions caused by spinal strain.

[0029] On the other hand, the present invention provides a drug for preventing, alleviating and / or treating degenerative lesions caused by spinal strain, wherein the active ingredient of the drug comprises the above-mentioned Chinese medicine composition.

[0030] It can be seen from the above technical scheme that the Chinese medicine composition with marrow-opening and rehabilitation effect of the present invention and its preparation method and application have at least the following beneficial effects:

[0031] The Chinese medicine composition of the present invention uses natural plant-based Chinese herbal medicines as raw materials, all of which are tonic and mainly improve human body function components, without any toxic side effects or adverse reactions to the human body.

[0032] However, it should be noted that for various hemorrhagic diseases, pregnant women and women during menstruation, as well as various critical stages of diseases, it should be used after the condition has been relieved and stabilized.

[0033] The Chinese medicine composition of the present invention can improve the overall metabolic environment of the human body, especially improve the metabolic environment of the spinal bone structure and bone marrow, enhance physical fitness, fundamentally restore spinal strain and degenerative lesions, promote overall health, and enhance local rehabilitation effects. DETAILED DESCRIPTION

[0034] In order to fully understand the purpose, features and effects of the present invention, the present invention is described in detail through the following specific embodiments. Except for the following contents, the process method of the present invention adopts conventional methods or devices in the art. Unless otherwise specified, the technical terms in the present invention have the meanings commonly understood by those skilled in the art.

[0035] Many diseases, such as obesity, deafness, tinnitus, functional constipation or cancer, are difficult to achieve long-term stable control and rehabilitation effects. The reason is that the current treatment methods only improve the symptoms of local lesions, but fail to improve the overall function of the human body. Therefore, they can only temporarily relieve and improve symptoms, but cannot truly improve the body's metabolism, promote cell detoxification and regeneration and repair, eliminate and reduce substantial damage, and continuously recover from the root. Improve the quality of life and function of the human body.

[0036] In view of the above problems, the inventors, in clinical treatment practice, based their use of TCM drugs on the Eight-Principle Syndrome Differentiation and Zang-Fu Dialectics, while constantly recognizing and understanding human life sciences, exploring the principles and laws of life operation, disease causes and disease repair, and based on cellular pathology and microcirculation theory, deeply realized that the damage caused by each disease is not independent, but is caused by metastatic damage to tissue cells in connected parts and progressive damage of early spinal strain degeneration, and gradually realized that spinal strain degeneration is the source of all diseases.

[0037] The strain and degeneration of the spine not only causes damage to the skin, flesh, tendons, and bone structures (periosteum, bone, and bone marrow) of all parts of the body, but also gradually penetrates into the internal organs, tissues, and cells to cause various comprehensive diseases, and the final result is the overall decline of the functions of all systems in the human body. In fact, the essence is the deficiency of qi, blood, yin and yang in the body and the deficiency of internal organs, as well as the partial prosperity and decline of yin and yang. All of these are caused by the stagnation of qi and blood in the body, especially the blockage of microcirculation, metabolic disorders, and accumulation of toxins in the bone structure and internal organs, which lead to various diseases. Therefore, the essence of Chinese medicine dialectics is deficiency and stasis. Long-term stasis will lead to deficiency, and stasis will turn into fire. Deficiency should be supplemented, and stasis should be dispersed. Therefore, the basis and principle of medication are further determined, with the general principles of greatly replenishing qi and blood, nourishing yin and strengthening yang, promoting blood circulation and removing stasis, and improving the functions of internal organs. It really improves metabolism in the body, promotes cell detoxification and regeneration and repair, improves the quality and function of human life, and enables the disease to recover and heal itself from the root.

[0038] Chinese medicine composition

[0039] Based on the research of the inventor, the present invention provides a Chinese medicine composition having a marrow-opening and rehabilitation effect, wherein the Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0040] 3-20 parts of red ginseng, 10-50 parts of astragalus, 5-30 parts of angelica, 5-30 parts of salvia, 5-30 parts of chuanxiong, 5-30 parts of white peony, 5-30 parts of tuckahoe, 5-30 parts of atractylodes, 5-20 parts of eucommia, 3-20 parts of cistanche, 3-20 parts of morinda officinalis, 5-20 parts of oxalis, 5-30 parts of safflower, 5-30 parts of chuanxiong, 3-15 parts of panax notoginseng, 5-30 parts of Pueraria root, 5-15 parts of bergamot, 5-15 parts of citron, 5-15 parts of cardamom, 5-30 parts of calamus, 5-30 parts of oriental rhizome, 5-15 parts of white mustard seeds, 5-30 parts of cornus officinalis, 5-20 parts of ophiopogon, 5-20 parts of rehmannia, 5-20 parts of lily, 5-30 parts of wolfberry, 5-20 parts of dried ginger, 5-30 parts of red dates, and 5-20 parts of roasted liquorice.

[0041] Preferably, the Chinese medicine composition is made from the following raw materials in parts by weight:

[0042] 5-10 parts of red ginseng, 25-35 parts of astragalus, 7-15 parts of angelica, 10-20 parts of salvia, 10-20 parts of chuanxiong, 10-20 parts of white peony, 10-20 parts of tuckahoe, 7-15 parts of atractylodes, 7-15 parts of eucommia, 3-10 parts of cistanche, 3-10 parts of morinda officinalis, 7-15 parts of oxalis, 7-15 parts of safflower, 10-20 parts of chuanxiong, 7-15 parts of panax notoginseng, 10-20 parts of Pueraria root, 7-12 parts of bergamot, 7-12 parts of citron, 7-12 parts of cardamom, 10-20 parts of calamus, 10-20 parts of oriental rhizome, 7-12 parts of white mustard seeds, 10-20 parts of cornus officinalis, 5-10 parts of ophiopogon, 5-10 parts of rehmannia, 5-10 parts of lily, 7-15 parts of wolfberry, 7-15 parts of dried ginger, 10-20 parts of red dates, and 7-15 parts of roasted liquorice.

[0043] More preferably, the Chinese medicine composition is made from the following raw materials in parts by weight:

[0044] 7 parts of red ginseng, 30 parts of astragalus, 10 parts of angelica, 15 parts of salvia miltiorrhiza, 10 parts of chuanxiong, 15 parts of white peony root, 15 parts of tuckahoe, 10 parts of atractylodes, 10 parts of eucommia, 5 parts of cistanche, 5 parts of morinda officinalis, 10 parts of oxalis, 10 parts of safflower, 15 parts of chuanduan, 10 parts of notoginseng, 15 parts of kudzu root, 10 parts of citron, 10 parts of cardamom, 15 parts of calamus, 15 parts of oriental rhizome, 10 parts of white mustard seeds, 15 parts of cornus officinalis, 7 parts of ophiopogon, 7 parts of rehmannia, 10 parts of lily, 10 parts of wolfberry, 10 parts of dried ginger, 15 parts of red dates, and 10 parts of roasted liquorice.

[0045] The various raw materials used in the present invention are all included in the Chinese Pharmacopoeia (2020 edition). It should be noted that the raw materials referred to in the present invention also include their water extracts, and granules made from their water extracts according to conventional processes, or commercially available Chinese medicine granules.

[0046] The Chinese medicine composition of the present invention can be in any conventional oral dosage form, for example, pills, tablets, capsules, granules, powders or oral liquids.

[0047] Compared with existing Chinese medicine prescriptions, the Chinese medicine composition of the present invention is a brand-new Chinese medicine component, which can greatly replenish qi and blood, balance yin and yang, promote blood circulation and remove blood stasis, penetrate into the periosteum and collaterals, improve microcirculation, improve the overall metabolic environment in the human body, enhance the functions of the skin, flesh, bones, internal organs, and tissue cells related to the spine, strengthen the tendons and bones, promote cell metabolism, detoxification and regeneration, thereby fundamentally recovering the strain and degeneration of the spine and rehabilitating the degenerative lesions.

[0048] Specifically, the effects (formula explanation) of each raw material of the Chinese medicine composition of the present invention are as follows:

[0049] 1. Among the first eight ingredients in the formula, red ginseng and astragalus are matched with angelica, salvia and chuanxiong. Red ginseng greatly replenishes vital energy, and astragalus helps red ginseng to replenish the qi of the lungs and spleen; angelica, salvia and chuanxiong replenish blood, activate blood circulation and promote qi circulation, replenishing without stagnation;

[0050] White peony root nourishes blood and restrains yin;

[0051] Atractylodes macrocephala and Poria cocos can strengthen the spleen and eliminate dampness, and assist ginseng in replenishing qi and strengthening the spleen.

[0052] 2. Eucommia bark, Cistanche deserticola, Morinda officinalis - tonify the kidney and strengthen yang, invigorate yang energy, and enhance life force. Tonify the kidney and replenish essence, essence and blood have the same origin, and essence is full of blood.

[0053] 3. Calamus, Rhizoma Alismatis, and Sinapis alba can dispel dampness and resolve phlegm. The three herbs are used together, and with the cooperation of other herbs in the prescription such as nourishing, promoting blood circulation and promoting qi, they can enhance the effect of eliminating phlegm, dampness, and toxic evil.

[0054] Traditional Chinese medicine believes that all diseases are caused by phlegm. Various pathogenic factors affect the functional activities of internal organs, which can gather moisture into phlegm, which flows between the internal organs and tissues, forming toxin accumulation. Removing dampness and resolving phlegm can help reduce the accumulation of toxins and eliminate them.

[0055] 4. Pueraria root, bergamot, cinnamon bark, and cardamom can soothe the liver, relieve depression, promote qi circulation, raise yang energy, promote overall blood circulation and remove blood stasis, and dissipate stasis.

[0056] 5. Cornus officinalis and wolfberry are good for nourishing the liver and kidneys, and improving eyesight.

[0057] 6. Ophiopogon japonicus, Radix Rehmanniae, and Lilium bulbs nourish the liver and kidneys, and nourish the yin of the lungs and stomach. They nourish without being dry, nourish yin and blood, and warm and nourish the kidney yang in the prescription, helping yin and yang, balancing yin and yang, and maintaining balance.

[0058] 6. Dried ginger and red dates: warming the spleen and stomach

[0059] 7. Roasted licorice root harmonizes all the medicines, replenishes qi and harmonizes the stomach.

[0060] 8. Niuxi, Safflower, Chuanduan and Panax notoginseng can promote blood circulation, remove qi and blood stasis, dredge meridians and activate collaterals, and unblock blood vessels. On the basis of the main medicines replenishing qi and blood, nourishing yin and strengthening yang, they strengthen blood circulation, remove blood stasis and dredge collaterals, penetrate deep into microcirculation to promote cell metabolism, and continuously detoxify and renew.

[0061] In short, the Chinese medicine composition of the present invention is used together to greatly replenish qi and blood, nourish yin and strengthen yang, and raise yang. On the basis of soothing the liver, strengthening the spleen and stomach, removing dampness and resolving phlegm, it promotes qi and blood circulation, removes blood stasis and dredges the collaterals, and dredges the blood vessels, so that qi and blood circulate deeply into the spinal bone structure, into the bones, into the marrow, and into the tiny collaterals, so that the skin, flesh, tendons, bones, bone structures, and tissue cells of the viscera and organs in the bone structure related to the spine are full of qi and blood, promotes microcirculation and circulation, enhances metabolism, especially promotes metabolic detoxification of the bone marrow, and promotes cell regeneration and repair; thereby, the fibrotic adhesions caused by strain and degeneration of the tissue cells of the spine and related bone structures throughout the body are continuously loosened and separated, repaired and regenerated, and the quality of life and function are enhanced, and the tendons and veins are truly unblocked, the bones are strong, the spine is upright, all diseases are difficult to occur, and the body is healthy.

[0062] Preparation method

[0063] The Chinese medicine composition of the present invention can be prepared into a conventional oral dosage form according to conventional methods with reference to relevant schemes in the prior art.

[0064] For example, the preparation method of the Chinese medicine composition of the present invention includes: a composition formed by crushing the above-mentioned raw materials separately and then mixing them; or, a composition obtained by mixing the above-mentioned raw materials and then crushing them; or, the above-mentioned raw materials are mixed and then extracted according to a conventional extraction method to obtain an extract, and the extract is further subjected to a refining and purification process to obtain an effective part, or the above-mentioned extract and effective part are further prepared according to a conventional preparation process to obtain a conventional oral dosage form.

[0065] The above-mentioned conventional extraction methods include maceration extraction, decoction extraction, reflux extraction, percolation extraction, ultrasonic extraction, microwave extraction, etc.; the extraction solvent includes water or conventional organic solvents, such as ethanol, methanol, ethyl acetate, petroleum ether, isopropanol, etc.; the refining and purification process includes extraction, column chromatography separation, high performance liquid chromatography separation, etc.

[0066] The conventional oral dosage forms include pills, tablets, capsules, granules, powders or oral liquids, etc. When preparing the above dosage forms, it is necessary to add common pharmaceutically acceptable excipients, including: fillers, disintegrants, lubricants, suspending agents, adhesives, sweeteners, flavoring agents, preservatives, bases, etc. Fillers include: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; disintegrants include: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, etc.; lubricants include: magnesium stearate, sodium lauryl sulfate, talc, silicon dioxide, etc.; suspending agents include: polyvinyl pyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, etc.; adhesives include starch slurry, polyvinyl pyrrolidone, hydroxypropyl methylcellulose, etc.

[0067] application

[0068] The Chinese medicine composition of the present invention has a marrow-opening and rehabilitation effect, and is suitable for spinal diseases and various related sub-health, metabolic syndrome and various chronic diseases and difficult diseases. The medication principle and effect are the same, and the ingredients are consistent, but there are certain differences in dosage according to different physical constitutions and different degrees of lesions. For example, for adults, when taking it at the beginning, 2 to 3 times a day, 2 grams to 5 grams each time, after taking the medicine for about a week, the dosage is gradually increased to 5 grams to 10 grams each time. At the same time, massage and stretching exercises are combined to continuously dredge the qi and blood meridians of the whole body.

[0069] The Chinese medicine composition of the present invention can also be prepared into medicine for the prevention, health care, relief and / or treatment of degenerative lesions of spinal strain. The specific preparation process can refer to the relevant schemes in the prior art and will not be described in detail here.

[0070] Example

[0071] The present invention is further described below by way of examples, but the present invention is not limited to the scope of the examples. The experimental methods in the following examples without specifying specific conditions are selected in accordance with national standards or industry standards, or according to conventional methods and conditions, or according to instrument operating instructions.

[0072] Example 1

[0073] Prescription: 7 grams of red ginseng, 30 grams of astragalus, 10 grams of angelica, 15 grams of salvia miltiorrhiza, 10 grams of chuanxiong, 15 grams of white peony, 15 grams of poria, 10 grams of atractylodes, 10 grams of eucommia, 5 grams of cistanche, 5 grams of morinda officinalis, 10 grams of nymphaeaceae, 10 grams of safflower, 15 grams of chuanduan, 10 grams of panax notoginseng, 15 grams of kudzu root, 10 grams of citron, 10 grams of cardamom, 15 grams of calamus, 15 grams of oriental water plantain, 10 grams of white mustard, 15 grams of cornus officinalis, 7 grams of ophiopogon, 7 grams of rehmannia, 10 grams of lily, 10 grams of wolfberry, 10 grams of dried ginger, 15 grams of red dates, and 10 grams of roasted licorice.

[0074] Preparation method (conventional water pill preparation process):

[0075] (1) Material preparation: drying, crushing, mixing, and grinding the raw materials through a 40-mesh sieve to obtain drug powder;

[0076] (2) Molding: The wet powder granulation molding method is used to make the molding powder into granules, and then the granules are rubbed and rotated to remove the edges and corners to form a pill mold;

[0077] (3) Molding: Similar to demolding, add water and drug powder alternately into the qualified pellet mold, and repeat the operation until the pellets are of appropriate size;

[0078] (4) Covering: cover with clean water;

[0079] (5) Drying: 60℃~70℃.

[0080] Example 2

[0081] Prescription: 5 grams of red ginseng, 25 grams of astragalus, 7 grams of angelica, 10 grams of salvia miltiorrhiza, 10 grams of chuanxiong, 10 grams of white peony, 10 grams of poria, 7 grams of atractylodes, 7 grams of eucommia, 3 grams of cistanche, 3 grams of morinda officinalis, 7 grams of nymphaeaceae, 7 grams of safflower, 10 grams of chuanduan, 7 grams of panax notoginseng, 10 grams of pueraria, 7 grams of citron, 7 grams of cardamom, 10 grams of calamus, 10 grams of oriental water plantain, 7 grams of white mustard, 10 grams of cornus officinalis, 5 grams of ophiopogon, 5 grams of rehmannia, 5 grams of lily, 7 grams of wolfberry, 7 grams of dried ginger, 10 grams of red dates, and 7 grams of roasted licorice.

[0082] The preparation method is the same as that in Example 1.

[0083] Example 3

[0084] Prescription: 10 grams of red ginseng, 35 grams of astragalus, 15 grams of angelica, 20 grams of salvia miltiorrhiza, 20 grams of chuanxiong, 20 grams of white peony, 20 grams of poria, 15 grams of atractylodes, 15 grams of eucommia, 10 grams of cistanche, 10 grams of morinda officinalis, 15 grams of nymphaeaceae, 15 grams of safflower, 20 grams of chuanduan, 15 grams of panax notoginseng, 20 grams of pueraria, 12 grams of citron, 12 grams of cardamom, 20 grams of calamus, 20 grams of oriental water plantain, 12 grams of white mustard, 20 grams of cornus officinalis, 10 grams of ophiopogon, 10 grams of rehmannia, 10 grams of lily, 15 grams of wolfberry, 15 grams of dried ginger, 20 grams of red dates, and 15 grams of roasted licorice.

[0085] The preparation method is the same as that in Example 1.

[0086] Example 4

[0087] Prescription: 6 grams of red ginseng, 28 grams of astragalus, 10 grams of angelica, 11 grams of salvia miltiorrhiza, 16 grams of chuanxiong, 16 grams of white peony, 14 grams of poria, 9 grams of atractylodes, 9 grams of eucommia, 4 grams of cistanche, 4 grams of morinda officinalis, 9 grams of nymphaeaceae, 8 grams of safflower, 16 grams of chuanduan, 9 grams of panax notoginseng, 16 grams of kudzu root, 9 grams of citron, 9 grams of cardamom, 13 grams of calamus, 13 grams of oriental water plantain, 8 grams of white mustard, 17 grams of cornus, 6 grams of ophiopogon, 6 grams of rehmannia, 6 grams of lily, 8 grams of wolfberry, 8 grams of dried ginger, 12 grams of red dates, and 8 grams of roasted licorice.

[0088] The preparation method is the same as that in Example 1.

[0089] Example 5

[0090] Prescription: 9 grams of red ginseng, 33 grams of astragalus, 12 grams of angelica, 18 grams of salvia miltiorrhiza, 18 grams of chuanxiong, 18 grams of white peony, 18 grams of poria, 9 grams of atractylodes, 9 grams of eucommia, 7 grams of cistanche, 7 grams of morinda officinalis, 10 grams of nymphaeaceae, 10 grams of safflower, 14 grams of chuanduan, 12 grams of panax notoginseng, 18 grams of kudzu root, 8 grams of citron, 8 grams of cardamom, 16 grams of calamus, 16 grams of oriental water plantain, 9 grams of white mustard, 16 grams of cornus, 7 grams of ophiopogon, 7 grams of rehmannia, 7 grams of lily, 12 grams of wolfberry, 12 grams of dried ginger, 18 grams of red dates, and 12 grams of roasted licorice.

[0091] Preparation method: Take each raw material medicine in proportion, add water and boil twice, and combine the decoctions.

[0092] Example 6

[0093] Prescription: 3 grams of red ginseng, 10 grams of astragalus, 5 grams of angelica, 5 grams of salvia miltiorrhiza, 5 grams of chuanxiong, 5 grams of white peony, 5 grams of poria, 5 grams of atractylodes, 5 grams of eucommia, 3 grams of cistanche, 3 grams of morinda officinalis, 5 grams of oxalis, 5 grams of safflower, 5 grams of chuanduan, 3 grams of panax notoginseng, 5 grams of pueraria, 5 grams of bergamot, 5 grams of citron, 5 grams of cardamom, 5 grams of calamus, 5 grams of oriental orientalis, 5 grams of white mustard, 5 grams of cornus officinalis, 5 grams of ophiopogon, 5 grams of rehmannia, 5 grams of lily, 5 grams of wolfberry, 5 grams of dried ginger, 5 grams of red dates, and 5 grams of roasted licorice.

[0094] The preparation method is the same as that of Example 5.

[0095] Example 7

[0096] Prescription: 20 grams of red ginseng, 50 grams of astragalus, 30 grams of angelica, 30 grams of salvia miltiorrhiza, 30 grams of Chuanxiong, 30 grams of white peony, 30 grams of Poria, 30 grams of Atractylodes, 20 grams of Eucommia, 20 grams of Cistanche, 20 grams of Morinda officinalis, 20 grams of Rhizoma Cynomorii, 30 grams of Safflower, 30 grams of Chuanduan, 15 grams of Panax notoginseng, 30 grams of Pueraria, 15 grams of Citron, 15 grams of Cardamom, 30 grams of Calamus, 30 grams of Alisma, 15 grams of White Sinapis, 30 grams of Cornus, 20 grams of Ophiopogon, 20 grams of Rehmannia, 20 grams of Lilium, 30 grams of Lycium barbarum, 20 grams of dried ginger, 30 grams of red dates, and 20 grams of roasted licorice.

[0097] The preparation method is the same as that of Example 5.

[0098] Example 8

[0099] Prescription: 4 grams of red ginseng, 23 grams of astragalus, 6 grams of angelica, 8 grams of salvia miltiorrhiza, 8 grams of chuanxiong, 8 grams of white peony, 8 grams of poria, 6 grams of atractylodes, 6 grams of eucommia, 4 grams of cistanche, 4 grams of morinda officinalis, 6 grams of nymphaeaceae, 6 grams of safflower, 4 grams of chuanduan, 4 grams of panax notoginseng, 8 grams of pueraria, 6 grams of citron, 6 grams of cardamom, 8 grams of calamus, 8 grams of oriental water plantain, 6 grams of white mustard, 8 grams of cornus officinalis, 6 grams of ophiopogon, 6 grams of rehmannia, 6 grams of lily, 6 grams of wolfberry, 6 grams of dried ginger, 8 grams of red dates, and 6 grams of roasted licorice.

[0100] Preparation method:

[0101] (1) Take each raw material drug in proportion, add water and boil twice, filter, take the decoction, concentrate, and prepare an extract;

[0102] (2) The extract is prepared into granules according to conventional granule preparation technology.

[0103] Example 9

[0104] Prescription: 18 grams of red ginseng, 45 grams of astragalus, 25 grams of angelica, 25 grams of salvia miltiorrhiza, 25 grams of chuanxiong, 25 grams of white peony, 25 grams of poria, 20 grams of atractylodes, 18 grams of eucommia, 18 grams of cistanche, 15 grams of morinda officinalis, 18 grams of nymphaeaceae, 20 grams of safflower, 25 grams of chuanduan, 14 grams of panax notoginseng, 25 grams of kudzu root, 14 grams of citron, 14 grams of cardamom, 25 grams of calamus, 25 grams of oriental water plantain, 14 grams of white mustard, 25 grams of cornus officinalis, 18 grams of ophiopogon, 18 grams of rehmannia, 18 grams of lily, 25 grams of wolfberry, 18 grams of dried ginger, 25 grams of red dates, and 18 grams of roasted licorice.

[0105] The preparation method is the same as that of Example 8.

[0106] Test Example 1

[0107] 1. Research purpose: Clinical observation on improving obesity and reducing body weight

[0108] 2. Research content and methods

[0109] 1. Sample Source

[0110] The cases came from the outpatient department of Beijing Yanhuang Hospital of Traditional Chinese Medicine (July 2013-December 2019).

[0111] Obesity was diagnosed according to the diagnostic criteria established in the Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes. 40 patients, including 18 males and 22 females, were included. The oldest patient was 68 years old, the youngest was 26 years old, the average age was 38 years old, the oldest onset age was 52 years old, the youngest onset age was 21 years old, and the average onset age was 32 years old. The longest course of the disease was 22 years, and the shortest was 3 years. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, and living and working environment among the patients (P>0.05), and the overall comparability was achieved. All patients or their legal guardians signed informed consent.

[0112] (II) Diagnostic criteria: The following diagnostic criteria are formulated based on the “Criteria for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes”.

[0113] 1. Western medicine diagnostic criteria

[0114] First, calculate the standard weight, which is equal to height (cm) minus 105. The measured weight is normal if it is within 10% of the standard weight, overweight if it is more than 10% but less than 20%, and obesity if the measured weight is more than 20% of the standard weight. For example, if the height is 170cm, the standard weight is 170cm minus 105, which is 65kg. 10% of more than 65kg is 71.5kg, so people who weigh more than 71.5kg are overweight. 20% of more than the standard weight of 65kg is 78kg, and people who weigh more than 78kg are obese. Medically, obesity is diagnosed using the body mass index, or BMI. BMI is the golden indicator for measuring obesity, which is equal to weight divided by the square of height. The normal BMI is between 18-24, if the BMI is between 24-28, it is overweight, and if it is more than 28, it is obese. Obesity can also be determined by measuring waist circumference. A waist circumference of >90cm for men and >85cm for women are the diagnostic criteria for abdominal obesity. The diagnostic criteria for obesity are mainly based on calculating BMI.

[0115] 2. Inclusion criteria

[0116] (1) Meet the above diagnostic criteria and age (18-60 years old)

[0117] (2) Patients who can cooperate with treatment and complete the prescribed course of treatment

[0118] 3. Exclusion criteria

[0119] (1) Those who were not treated according to the prescribed treatment, whose efficacy could not be determined, or whose data were incomplete or who were out of observation;

[0120] (2) Other related treatments may affect the observation of indicators;

[0121] (3) Patients with other diseases that may affect obesity, such as hypothyroidism, hypothalamic or pituitary diseases, pancreatic islet-related diseases, etc. Pregnant and lactating women and mentally ill patients.

[0122] (III) Treatment methods

[0123] 1. The Chinese medicine composition (water pill) prepared in Example 1 is 5 grams per bag. 5 grams at a time, twice a day, accompanied by massage techniques and stretching exercises, and gradually increased to 10 grams at a time, two to three times a day within two weeks; one month is one course of treatment, and three months is one cycle.

[0124] 2. Massage techniques to clear the Ren and Du meridians, the Jiaji points on both sides of the spine, and the two bladder meridians on the back. Frequency (twice to three times a week, 30-45 minutes each time)

[0125] 3. Stretching exercises, through upper and lower limb stretching activities to stimulate the whole body, two to three times a day, 20-30 minutes each time, at least 60 minutes a day.

[0126] (IV) Observation indicators

[0127] 1. Baseline data

[0128] 2. Weight loss

[0129] The patients' body weight was measured and recorded using the same standard weighing scale before and after treatment.

[0130] 3. Overall efficacy

[0131] (V) Efficacy standards

[0132] Obviously effective: within one to three months, weight loss of 5-10 kg or slightly more.

[0133] Generally effective: within one to three months, weight loss is within 3kg-5Kg.

[0134] Minor improvement: Weight loss within 1Kg-3Kg within one month.

[0135] Ineffective: No change in body weight within one month.

[0136] 6. Statistical methods

[0137] 1. Use SPSS20.0 software and Excel for statistical processing

[0138] 2. Paired sample t test was used for normal distribution data of count data, χ2 test was used for measurement data, and non-parametric test was used for non-normal distribution data. The results were expressed as mean ± standard deviation (ˋx±s), and P < 0.05 was considered statistically significant.

[0139] 3. Results

[0140] A total of 40 obese patients were included in this study, including 18 males and 22 females. The oldest patient was 68 years old, the youngest was 26 years old, the average age was 38 years old, the oldest onset age was 52 years old, the youngest onset age was 21 years old, the average onset age was 34 years old, the longest course of the disease was 22 years, and the shortest was 3 years. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, living and working environment among the patients (P>0.05), and the overall comparability was achieved.

[0141] Obviously effective: within one to three months, the weight loss was 5-10 kg or slightly more. 8 males, 7 females;

[0142] Generally effective: within one to three months, weight loss is within 3kg-5Kg. 6 males and 12 females;

[0143] Minor improvement: Weight loss within 1kg-3kg within one to three months. 4 males and 3 females.

[0144] Ineffective: no weight change within one month, 0 people;

[0145] Overall efficacy: According to the concept of TCM rehabilitation prescription, it can greatly replenish qi and blood, balance yin and yang, activate blood circulation and remove blood stasis, increase the function of internal organs, strengthen metabolism and eliminate phlegm, dampness, toxins and various toxins. The patient's overall physical fitness is enhanced, metabolism and detoxification are increased, and weight is naturally reduced.

[0146] Test Example 2

[0147] 1. Research purpose: Clinical observation on the improvement of recovery of cancer patients after postoperative radiotherapy and chemotherapy

[0148] 2. Research content and methods

[0149] 1. Sample Source

[0150] For general information, the cases were sourced from Beijing Yanhuang Hospital of Traditional Chinese Medicine and Xiaolu Traditional Chinese Medicine Online Clinic (March 2017 - November 2022).

[0151] According to the diagnostic criteria established by the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes", patients diagnosed with advanced cancer had obvious physical weakness after surgery, radiotherapy and chemotherapy, especially low neutrophil counts in blood routine. 19 patients, including 9 males and 10 females, aged 44-84 years old. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, living and working environment (P>0.05), and the overall comparability was achieved. All patients or their legal guardians signed informed consent.

[0152] (II) Diagnostic criteria: The following diagnostic criteria are formulated based on the “Criteria for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes”.

[0153] 1. Western medicine diagnostic standards: Routine blood test is a commonly used examination indicator in clinical practice, and the focus is generally on the values ​​of white blood cells, red blood cells, platelets, hemoglobin, etc.

[0154] Normal range of four items of blood routine test:

[0155] (1) The normal value of white blood cell count is (4-10)×10^9 / L.

[0156] (2) The red blood cell count in males is (4-5.5)×10^12 cells / L, and in females is (3.5-5.0)×10^12 cells / L.

[0157] (3) Hemoglobin concentration measurement: the range for men is 120-160 g / L and for women is 110-150 g / L

[0158] (4) The normal range of platelet count is (100-300)×10^9 / L.

[0159] In this clinical observation, the patients' blood, lymphatic, immune, and digestive systems were severely damaged after postoperative radiotherapy and chemotherapy for cancer. Their physical condition was obviously weak, and the four indicators of blood routine were all below the normal range. After supplementation with Western medicine such as white blood cell and platelet-raising drugs, they reached the lower normal line, or white blood cells were above 2×10^9 / L, red blood cells were above 2.5×10^12 / L, hemoglobin was above 80g / L, and platelets were above 50×10^9 / L.

[0160] 2. Inclusion criteria

[0161] (1) Meet the above diagnostic criteria and age (44-78 years old)

[0162] (2) Patients who can cooperate with treatment and complete the prescribed course of treatment

[0163] 3. Exclusion criteria

[0164] (1) Those who were not treated according to the prescribed treatment and whose efficacy cannot be determined or whose data are incomplete or who have dropped out of observation.

[0165] (2) Other related treatments may affect the observation of indicators;

[0166] (3) Combination with other diseases that may affect this condition, such as hemorrhagic diseases, mental illness, etc.

[0167] (III) Treatment methods

[0168] 1. The Chinese medicine composition (water pills) prepared in Example 1, 5 grams per bag.

[0169] 2. Usage, dosage and course of treatment

[0170] In the first week, take 2-5 grams each time, two to three times a day, and gradually increase to 5-10 grams, three to four times a day. One month is a course of treatment, and three months is a cycle. The dosage for health care and rehabilitation should be continuously increased.

[0171] 3. Massage techniques to clear the Ren and Du meridians, the Jiaji points on both sides of the spine, and the two bladder meridians on the back. The frequency is (twice to three times a week, 30-45 minutes each time). 4. Gradually increase the muscle stretching activities from 10-20 minutes a day, twice a day, gradually increase to 20-40 minutes a day, twice a day, upper and lower limb activities, and whole body activities.

[0172] (IV) Observation indicators

[0173] 1. Baseline data

[0174] 2. Increase in the four main indicators of blood routine

[0175] Patients' blood routine examination records before treatment

[0176] 3. Overall efficacy

[0177] (V) Efficacy standards

[0178] Obviously effective: within one to three months, all four top indicators are improved or return to normal, or increase by more than one unit.

[0179] Generally effective: within one to three months, all four indicators will improve, or reach normal, or one of them will improve by less than one unit.

[0180] Small amounts of results will be seen: within one to three months, all four indicators will be improved, or reach normal, or two of them will increase by less than one unit.

[0181] Invalid: No changes in the four indicators within one month.

[0182] 6. Statistical methods

[0183] 1. Use SPSS20.0 software and Excel for statistical processing

[0184] 2. The paired sample t test was used for the normally distributed data of count data, the chi-square test was used for the measurement data, and the non-parametric test was used for the non-normally distributed data. The results were expressed as mean ± standard deviation (`x ± s), and P < 0.05 was considered statistically significant.

[0185] 3. Results

[0186] 1. General

[0187] A total of 19 patients with this disease were included in this study, including 9 males and 10 females. The oldest patient was 84 years old and the youngest was 44 years old. The oldest onset age was 77 years old and the youngest onset age was 43 years old. The longest course of the disease was 7 years and the shortest was 1 year. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, living and working environment among the patients (P>0.05), and the overall comparability was achieved.

[0188] Obviously effective: Within one to three months, all four indicators have improved or returned to normal, or increased by more than one unit. Male 6 Female 7

[0189] Generally effective: Within one to three months, all four indicators will be improved, or reach normal, or one of them will be improved by less than one unit.

[0190] Small amount of treatment will be effective: within one to three months, all four indicators will be improved, or return to normal, or two of them will be improved by less than one unit.

[0191] Invalid: No change in the four indicators within one month.

[0192] Overall efficacy: According to the concept of TCM rehabilitation prescription, it can replenish qi and blood, balance yin and yang, activate blood circulation and remove stasis, increase the function of internal organs, strengthen metabolism and eliminate phlegm, dampness, toxins and various toxins. The overall function of the major systems of the patient is improved, immunity is enhanced, and recurrence and metastasis are fundamentally controlled.

[0193] Test Example 3

[0194] 1. Research purpose: Clinical observation on the improvement and recovery of various functional constipation

[0195] 2. Research content and methods

[0196] 1. Sample Source

[0197] The cases were from Beijing Yanhuang Hospital of Traditional Chinese Medicine (March 2003 - October 2022)

[0198] Patients diagnosed with constipation according to the diagnostic criteria established in the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes". 30 patients, including 17 males and 13 females, the oldest patient was 83 years old and the youngest patient was 20 years old. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, living and working environment among the patients (P>0.05), and the overall comparability was achieved. All patients or their legal guardians signed informed consent.

[0199] (II) Diagnostic criteria: The following diagnostic criteria are formulated based on the “Diagnosis and Efficacy Criteria of Traditional Chinese Medicine Diseases and Syndromes”.

[0200] 1. Western medicine diagnostic criteria: If constipation symptoms began six months ago, loose stools rarely occur without the use of laxatives, and the patient does not meet the diagnostic criteria for irritable bowel syndrome, functional constipation can be diagnosed if two or more of the following symptoms are met in the past three months:

[0201] (1) At least 25% of bowel movements are labored;

[0202] (2) At least 25% of the stools are dry or hard;

[0203] (3) Feeling of incomplete defecation in at least 25% of cases;

[0204] (4) Anorectal obstruction or blockage in at least 25% of bowel movements;

[0205] (5) At least 25% of bowel movements require manual assistance;

[0206] (6) Bowel movements less than 3 times per week.

[0207] 2. Inclusion criteria

[0208] (1) Meet the above diagnostic criteria and age (20-83 years old)

[0209] (2) Patients who can cooperate with treatment and complete the prescribed course of treatment

[0210] 3. Exclusion criteria

[0211] (1) Those who were not treated according to the prescribed treatment, whose efficacy could not be determined, or whose data were incomplete or who were out of observation;

[0212] (2) Other related treatments may affect the observation of indicators;

[0213] (3) Patients with other diseases that may affect this condition, excluding constipation caused by organic diseases of the colon, rectum and anus, and other endocrine diseases (such as diabetes), nervous system diseases (such as peripheral neuropathy) and certain drugs (such as antidepressants).

[0214] (III) Treatment methods

[0215] 1. The Chinese medicine composition (water pills) prepared in Example 2, 5 grams per bag.

[0216] 2. Usage, dosage and course of treatment

[0217] In the first week, start with 2-5 grams each time, two to three times a day, and gradually increase to 5-10 grams, three to four times a day. One course of treatment is one month, one cycle is three months, and a total of two to four cycles or longer.

[0218] 3. Massage techniques to clear the Ren and Du meridians, the Jiaji points on both sides of the spine, and the two bladder meridians on the back. Frequency (twice to three times a week, 30-45 minutes each time)

[0219] 4. Stretching exercises, 10-20 minutes each time, two to three times a day, at least 40-60 minutes a day, including upper and lower limb activities, and whole body activities.

[0220] (IV) Observation indicators

[0221] 1. Baseline data

[0222] 2. Six characteristics of functional constipation

[0223] Six characteristics and frequency of constipation in patients before treatment

[0224] 3. Overall efficacy

[0225] (V) Efficacy standards

[0226] Obviously effective: Within three to six months, the six characteristics of constipation are improved and the number of bowel movements is no less than five times.

[0227] Generally effective: within three to six months, six characteristics of constipation are restored and bowel movements are no less than four times a week.

[0228] Effective with a small amount: within three to six months, all six constipation symptoms will improve. Bowel movements should be no less than three times a week.

[0229] 6. Statistical methods

[0230] 1. Use SPSS20.0 software and Excel for statistical processing

[0231] 2. Paired sample t test was used for normal distribution data of count data, χ2 test was used for measurement data, and non-parametric test was used for non-normal distribution data. The results were expressed as mean ± standard deviation (ˋx±s), and P < 0.05 was considered statistically significant.

[0232] 3. Results

[0233] 1. General

[0234] A total of 30 patients with this disease were included in this study, including 17 males and 13 females. The oldest patient was 83 years old and the youngest was 20 years old. The oldest onset age was 78 years old and the youngest onset age was 15 years old. The longest course of the disease was 20 years and the shortest was 1 year. After statistical testing, there was no statistical difference in general clinical data such as age, gender, living and working environment.

[0235] Significantly effective: Within three to six months, all six constipation characteristics were improved, and the number of bowel movements was no less than five times.

[0236] Generally effective: within three to six months, six constipation characteristics are restored, and the number of bowel movements per week is no less than four times. Male 8, Female 7

[0237] Small amount of treatment will be effective: within three to six months, all six constipation symptoms will be improved. Defecation should be no less than three times a week.

[0238] Test Example 4

[0239] 1. Research purpose: Clinical observation on the improvement and recovery of deafness

[0240] 2. Research content and methods

[0241] (I) Sample source: Cases were from Beijing Yanhuang Hospital of Traditional Chinese Medicine (March 2003 - October 2022)

[0242] According to the Diagnosis and Efficacy Standards of TCM Diseases and Syndromes, 35 patients were diagnosed with sudden deafness within one month to six months, including 19 males and 16 females, with the oldest being 83 years old and the youngest being 13 years old. After statistical testing, there was no statistically significant difference in general clinical data such as age, gender, and living and working environment among the patients (P>0.05), and the overall comparability was achieved. All patients or their legal guardians signed informed consent.

[0243] (II) Diagnostic criteria: The following diagnostic criteria are formulated based on the “Criteria for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes”.

[0244] 1. Western medicine diagnostic standards: If sudden deafness does not recover after various treatments of Chinese and Western medicine, it can be diagnosed mainly through hearing tests. If the hearing is within 25 decibels, it is within the normal range. If the hearing is 26-40 decibels, it is mild deafness. If the hearing is 41-55 decibels, it is moderate deafness. If the hearing is 56-70 decibels, it is moderate to severe deafness. If the hearing is more than 70 decibels, it is severe or extremely severe deafness.

[0245] 2. Inclusion criteria

[0246] (1) Meet the above diagnostic criteria and age (14-84 years old)

[0247] (2) Patients who can cooperate with treatment and complete the prescribed course of treatment

[0248] 3. Exclusion criteria

[0249] (1) Those who were not treated according to the prescribed treatment, whose efficacy could not be determined, or whose data were incomplete or who were out of observation;

[0250] (2) Other related treatments may affect the observation of indicators;

[0251] (3) Combination with other diseases that may affect this condition.

[0252] (III) Treatment methods

[0253] 1. The Chinese medicine composition (water pills) prepared in Example 3, 5 grams per bag.

[0254] 2. Usage, dosage and course of treatment

[0255] In the first week, start with 2-5 grams each time, two to three times a day, and after two weeks gradually increase to 5-10 grams, three to four times a day.

[0256] 3. Massage techniques to clear the Ren and Du meridians, the Jiaji points on both sides of the spine, and the two bladder meridians on the back. Frequency (twice to three times a week, 30-45 minutes each time)

[0257] 4. Stretching exercises, 10-20 minutes each time, two to three times a day, at least 40 to 60 minutes a day, including upper and lower limb activities, and whole body activities.

[0258] (IV) Observation indicators

[0259] 1. Baseline data

[0260] 2. The patients are all deaf on one side

[0261] The patients had an electrical audiometry test record before treatment.

[0262] (V) Efficacy standards

[0263] Significantly effective: Hearing improved by 40 decibels or more to normal within one to three months

[0264] Generally effective: within one to three months, hearing will improve by less than 30 decibels

[0265] Effective with a small amount: within one to three months, hearing will improve by less than 20 decibels

[0266] Ineffective: There is no improvement in hearing within three months, but with continued rehabilitation, there will be gradual overall improvement, improved physical fitness, improved overall function, and hearing will gradually improve, and recovery is expected.

[0267] 6. Statistical methods

[0268] 1. Use SPSS20.0 software and Excel for statistical processing

[0269] 2. Paired sample t test was used for normal distribution data of count data, χ2 test was used for measurement data, and non-parametric test was used for non-normal distribution data. The results were expressed as mean ± standard deviation (ˋx±s), and P < 0.05 was considered statistically significant.

[0270] 2. Results

[0271] 1. General

[0272] A total of 35 patients with this disease were included in this study, including 19 males and 16 females. The oldest patient was 83 years old and the youngest was 13 years old. The oldest onset age was 76 years old and the youngest onset age was 6 years old. The longest course of the disease was six months and the shortest was one month. After statistical testing, there was no statistical difference in general clinical data such as age, gender, living and working environment.

[0273] Significantly effective: hearing improved by 40 decibels in one to three months, 9 males and 7 females

[0274] Generally effective: within one to three months, hearing will improve by less than 30 decibels, 8 for males and 7 for females

[0275] Effective with a small amount: within one to three months, hearing will improve by less than 20 decibels, 2 males and 2 females

[0276] Overall efficacy: According to the concept of TCM rehabilitation prescription, it can replenish qi and blood, balance yin and yang, activate blood circulation and remove stasis, increase the function of internal organs, strengthen metabolism and eliminate phlegm, dampness, toxins and various toxins. The patient's overall physical fitness is enhanced, the overall function is improved, and the hearing function is naturally improved.

[0277] Clinical Case 1

[0278] Basic situation: The patient, Ms. Yin, 42 years old, came to the clinic on September 25, 2022. In January, she was diagnosed with the most malignant signet ring cell carcinoma of the stomach, which was close to the late stage (stage III). She had surgery after chemotherapy and is undergoing chemotherapy after surgery. General status: diet, sleep, defecation, etc., are difficult to maintain, sometimes diarrhea, often increased to five or six times a day, extremely weak body, fatigue, cold legs, afraid of wind, easy to catch a cold, hair loss, face full of spots, amenorrhea for more than half a year. The patient is depressed, sad, tearful, fearful, and worried. In terms of test indicators, the white blood cells and red blood cells in the blood are low. He takes Licojun, compound soap alum tablets, etc., which are still at the normal low line. In the past, he often had dizziness since childhood, and secretory otitis media had recurred. This time he had gastritis and stomach discomfort a few years ago. Various treatments did not fundamentally improve, but suddenly worsened.

[0279] Dosage: Take the Chinese medicine composition (water pill) prepared in Example 1, starting with 3 grams once, three times a day, gradually increasing to 5 to 10 grams once, three to four times a day. With rehabilitation therapy, the general condition is basically normal within two weeks, and the blood routine is also significantly improved. After three months, the recovery and improvement are significant, the living condition is completely normal, the mood naturally improves, and normal work is resumed.

[0280] The patient was infected with the new coronavirus in December 2022. After recovery, he suffered a recurrence of secretory otitis media, fluid accumulation in the ear, stuffiness, and pain in the ear. After more than a month of Western medicine infusion and medication, the symptoms did not improve.

[0281] Dosage: After taking the Chinese medicine composition (water pills) prepared in Example 1, and taking the corresponding heat-clearing and detoxifying Chinese medicine twice, the recovery was significantly improved. On February 1, 2023, he came to the outpatient clinic to further strengthen his rehabilitation. His condition changed significantly compared with the initial diagnosis, and he recovered comprehensively as a whole. Continue to take the Chinese medicine composition (water pills) prepared in Example 1 according to the rehabilitation cycle, 5-10 grams at a time, two to three times a day, with massage and stretching exercises, and continue to recover for at least one year or longer. The overall functions of various systems of the body are improved, the immune system is enhanced, and the recurrence and metastasis are effectively controlled. Now I firmly believe in a long-term healthy and happy life, and have been working normally for more than three months. This is also a process of preventive health care and rehabilitation.

[0282] The patient underwent blood cell analysis on September 25, 2022, January 17, 2023, and February 25, 2023. The test results on September 25, 2022 were: white blood cell count was 3.54, red blood cell count was 4.03, hemoglobin was 127, and platelet count was 224 (he had taken drugs to increase white blood cell count and platelet count before). The test results on January 17, 2023 were: white blood cell count was 4.40, red blood cell count was 4.90, hemoglobin was 148, and platelet count was 221. The test results on February 25, 2023 were: white blood cell count was 5.45, red blood cell count was 4.09, hemoglobin was 127, and platelet count was 224.

[0283] Clinical Case 2

[0284] Basic situation: Mr. Liu came to the clinic on October 25, 2022, 44 years old. He was diagnosed with osteosarcoma in June, in the middle and late stages, and underwent surgery to replace the prosthesis. He underwent chemotherapy 6 times after surgery and was cured. In general, he had difficulty maintaining diet, sleep, and defecation, was weak, tired, had stomach discomfort, had severe oral ulcers, which affected his eating, had bitter mouth and yellow urine, and had all kinds of discomfort in his body. The white blood cell, red blood cell, and platelet indexes in the blood routine were low. He had a good physical condition in the past, did not pay attention to rest, overdrawn, had leg pain for more than half a year before the onset of the disease, and repeated treatment did not improve, which worsened.

[0285] Dosage: Take the Chinese medicine composition (water pill) prepared in Example 1, 3 grams at a time, three times a day, gradually increase to 5 grams to 10 grams at a time, twice to three times a day, and basically return to normal within two weeks in the early stage. Blood routine tests all improve to normal. Resume work after more than two months. Adhere to continuous recovery and live a long and healthy life. Compared with the patients who received Western medicine treatment at the same time, the body function, life status, and quality of life have obviously recovered and improved the fastest.

[0286] The patient's blood routine before the visit was 1.95 white blood cells, 3.41 red blood cells, 105 hemoglobin, 146 platelets, and even as low as 8 platelets. He has been using drugs to increase white blood cells and platelets, but it is unstable. He was treated according to the above medication method and tested on November 20, 2022 and January 26, 2023. The test results on November 20, 2022 were: 3.50 white blood cells, 3.99 red blood cells, 132 hemoglobin, and 167 platelets. The test results on January 26, 2023 were: 4.09 white blood cells, 5.09 red blood cells, 161 hemoglobin, and 171 platelets.

[0287] Clinical Case 3

[0288] Basic information: Ms. Li, 78 years old, came to the clinic on March 11, 2018.

[0289] Liver cancer was discovered in October 2017. After receiving Gold Standard Radiotherapy at the 301 Hospital, there were still residual tumors and severe physical damage. Blood count was low, and platelets dropped to 46,000. Subcutaneous bruises appeared continuously on the legs and upper limbs. Coughing and wheezing occurred, and blood-streaked sputum appeared. Lung CT examination showed metastasis to both lungs. Diet and sleep were poor, physical weakness, general edema, palpitations, chest tightness, dizziness, difficulty walking, and very poor quality of life.

[0290] Medication method: Take the Chinese medicine for hemostasis in the early stage, and it will be stable after one week. Start to take the Chinese medicine composition (water pill) prepared in Example 1, 3 grams to 5 grams at a time, two to three times a day, and gradually increase to 5 to 10 grams at a time, two to three times a day. Within two weeks, the patient's general condition has improved significantly, diet and sleep, general edema, lung symptoms, subcutaneous bruises, etc. have fully recovered, and the quality of life is basically normal. At three months, the lung CT review is the same as before, and the residual tumor in the liver has disappeared. Continue to visit again, more than a year, health care recovery, control recurrence and metastasis, stable condition, overall comprehensive recovery, various biochemical indicators have improved significantly, and no physical examination is done again. The living status is still normal, and it has been the seventh year so far.

[0291] This case is a case of liver cancer after radiotherapy. The overall damage is large, lung metastasis occurs, and pancytopenia, severe thrombocytopenia, and subcutaneous bleeding occur. The patient is a critically ill patient, and his life is in danger. After the acute symptoms are relieved, the long-term use of the Chinese medicine composition of the present invention has achieved fundamental and comprehensive recovery. It should be a breakthrough case, and it also proves the substantial efficacy of the Chinese medicine composition of the present invention.

[0292] Clinical Case 4

[0293] Basic information: Male patient, 62 years old, came to the clinic on June 28, 2018.

[0294] The patient was diagnosed at the end of April 2017 and underwent gastric cancer surgery on May 1. The patient was in the late stage of gastric cancer and had ascites due to liver cirrhosis. He was weak and emaciated. He had repeated drainage 4 times in more than half a year, each time weighing about 15 pounds. The patient stopped chemotherapy immediately after the gastric cancer surgery and was diagnosed with ascites due to liver cirrhosis.

[0295] Dosage: Early application of the Chinese medicine composition (water pills) prepared in Example 1, 3-5 grams at a time, three to four times a day, plus Chinese medicine for diuresis and dampness. Within a week, the mental state and physical strength improved significantly. The dosage was increased to 5-10 grams at a time, two to three times a day. The recovery lasted for nearly half a year, and the ascites gradually decreased. After the water was drained on November 1, no ascites was produced again, and the weight increased by 15 pounds. Adhere to intermittent use of this rehabilitation water pill, and stretching exercises, the physical condition and living state are completely restored to normal. Healthy and happy life, it has been six years.

[0296] This case is a patient with advanced gastric cancer and ascites due to liver cirrhosis. The patient is in critical condition. The Chinese medicine composition of the present invention and other diuretic Chinese medicines, combined with rehabilitation therapy, after the condition is relieved, long-term use of the Chinese medicine composition of the present invention is also a breakthrough case of overall and comprehensive recovery from the root, further proving the substantial effect of the rehabilitation pills. It is also difficult to achieve with other various medications.

[0297] Clinical Case 5

[0298] Basic information: Male patient, 33 years old, came to the clinic on November 13, 2017.

[0299] Due to fatigue from moving, he suddenly developed cervical pain, which radiated to his right shoulder and arm, as if cut by a knife or electroshocked. The pain was extreme, taking him half an hour to lie down and half an hour to get up. He had to use a straw to drink water. He took a taxi to the Tibetan hospital for treatment. The bumpy ride on the road made the pain unbearable. An MRI examination showed cervical disc herniation and he needed hospitalization for surgery. He was advised to take stronger painkillers, such as acetaminophen and codeine tablets, but the pain did not subside.

[0300] Dosage: After consulting and asking about the medical history, first make the patient take 3 grams of the Chinese medicine composition (water pills) prepared in Example 1. The patient is required to lie down. If the patient cannot lie down, he will stand up with a blanket (the patient cannot cooperate with the massage technique in a lying position for treatment, and can only lean on the blanket to lie in a semi-lying position) for massage treatment. With the effect of the medicine and massage, the patient's pain is relieved and he can continue the treatment in a lying position for three consecutive hours. After the treatment, the patient is asked to take 3 grams of water pills again. The patient gets up to eat and goes out without obvious obstacles. Then continue to take water pills, 3 grams at a time, three times a day. After the second treatment, stop taking painkillers, and increase the dose of this pill to 3 grams at a time, four times a day. The patient can move normally for the third time and returns to normal within a week. One week later, take 5 grams of this pill two to three times a day, in conjunction with stretching activities, to gradually improve the overall metabolism of the whole body and continuously recover from the root,

[0301] The recovery cycle of the human body is three months. You can take the medicine for long-term recovery, or you can reduce the dosage and maintain it at 2-5 grams each time, once or twice a day, or take it intermittently for recovery. It plays a role in preventive health care, controlling the development and aggravation of the disease, and recurrence. Cervical disc herniation is mainly caused by the protruding part, which compresses the peripheral nerves and blood vessels of the relevant segments of the cervical spine, causing tissue cell ischemia, hypoxia, degeneration and necrosis, fibrosis and adhesion. With age, it progresses and aggravates degeneration, spreads to local and related parts, and increases damage. It affects local and overall functions, especially when it aggravates to a certain extent, the local attack will definitely be aggravated, and the consequences are serious.

[0302] Clinical Case 6

[0303] Basic information: Mr. Lin, 78 years old, came to the clinic on March 2, 2015.

[0304] The patient suffered sudden deafness and aphonia in both ears for more than two weeks. After the onset of the disease, he received intravenous drip in Beijing Hospital for two weeks, but there was no improvement. He also had poor sleep and took sleeping pills, but his general condition was acceptable.

[0305] Dosage: Take the Chinese medicine composition (water pill) prepared in Example 1, 3-5 grams at a time, two to three times a day, and you can hear the sound on the second day, and you can communicate normally after five times. The dosage is increased to 5-10 grams at a time, two to three times a day. Adhere to taking this rehabilitation pill, cooperate with rehabilitation therapy, and the overall recovery is complete. Stop taking sleeping pills for three months, and re-examine for 8 months. Continue to take the medicine for a long time or intermittently, and the hearing is still good so far.

[0306] This case should be considered a breakthrough in deafness rehabilitation. Generally, sudden deafness in the elderly does not improve in the early stages and is difficult to recover, and most cases result in irreversible permanent deafness.

[0307] Clinical Case 7

[0308] Basic information: Ms. Tang, female, 55 years old, came to the clinic on January 13, 2017.

[0309] The right side of the face is paralyzed for nearly four months. The left eye cannot be closed, tears flow, eyes are dazed, air leaks from the corner of the mouth, chewing is weak, speech is difficult, etc. After various acupuncture, moxibustion and plastering treatments, there is no improvement in four months. It has turned into a chronic disease, the muscles are stiff and dead. There are also severe metabolic syndrome, high blood lipids, cervical spondylosis, dizziness, easy to drop objects held in the right hand, and back pain for more than 20 years.

[0310] Dosage: Take the Chinese medicine composition (water pill) prepared in Example 1 once 3-5 grams, two to three times a day, and the condition is significantly improved after one treatment, and all facial muscles feel active. Continuous rehabilitation method, increase the dosage to 5-10 grams, two to three times a day, the facial nerve function is significantly improved, closing eyes, chewing, tearing, and language are significantly improved, long-term use of Benkangfu pills for continuous recovery, local basic recovery, overall comprehensive improvement, back pain is also restored.

[0311] This case is a sequela of facial paralysis, which should be irreversible and difficult to recover. It is also a breakthrough case of the application of the Chinese medicine composition of the present invention, which is difficult to achieve with other therapies.

Claims

1. A Chinese medicine composition having a marrow-opening and rehabilitation effect, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 3-20 parts of red ginseng, 10-50 parts of astragalus, 5-30 parts of angelica, 5-30 parts of salvia, 5-30 parts of chuanxiong, 5-30 parts of white peony, 5-30 parts of tuckahoe, 5-30 parts of atractylodes, 5-20 parts of eucommia, 3-20 parts of cistanche, 3-20 parts of morinda officinalis, 5-20 parts of oxalis, 5-30 parts of safflower, 5-30 parts of chuanxiong, 3-15 parts of panax notoginseng, 5-30 parts of Pueraria root, 5-15 parts of bergamot, 5-15 parts of citron, 5-15 parts of cardamom, 5-30 parts of calamus, 5-30 parts of oriental rhizome, 5-15 parts of white mustard seeds, 5-30 parts of cornus officinalis, 5-20 parts of ophiopogon, 5-20 parts of rehmannia, 5-20 parts of lily, 5-30 parts of wolfberry, 5-20 parts of dried ginger, 5-30 parts of red dates, and 5-20 parts of roasted liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 5-10 parts of red ginseng, 25-35 parts of astragalus, 7-15 parts of angelica, 10-20 parts of salvia, 10-20 parts of chuanxiong, 10-20 parts of white peony, 10-20 parts of tuckahoe, 7-15 parts of atractylodes, 7-15 parts of eucommia, 3-10 parts of cistanche, 3-10 parts of morinda officinalis, 7-15 parts of oxalis, 7-15 parts of safflower, 10-20 parts of chuanxiong, 7-15 parts of panax notoginseng, 10-20 parts of Pueraria root, 7-12 parts of bergamot, 7-12 parts of citron, 7-12 parts of cardamom, 10-20 parts of calamus, 10-20 parts of oriental rhizome, 7-12 parts of white mustard seeds, 10-20 parts of cornus officinalis, 5-10 parts of ophiopogon, 5-10 parts of rehmannia, 5-10 parts of lily, 7-15 parts of wolfberry, 7-15 parts of dried ginger, 10-20 parts of red dates, and 7-15 parts of roasted liquorice.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition is made of the following raw materials in parts by weight: 7 parts of red ginseng, 30 parts of astragalus, 10 parts of angelica, 15 parts of salvia miltiorrhiza, 10 parts of chuanxiong, 15 parts of white peony root, 15 parts of tuckahoe, 10 parts of atractylodes, 10 parts of eucommia, 5 parts of cistanche, 5 parts of morinda officinalis, 10 parts of oxalis, 10 parts of safflower, 15 parts of chuanduan, 10 parts of notoginseng, 15 parts of kudzu root, 10 parts of citron, 10 parts of cardamom, 15 parts of calamus, 15 parts of oriental rhizome, 10 parts of white mustard seeds, 15 parts of cornus, 7 parts of ophiopogon, 7 parts of rehmannia, 10 parts of lily, 10 parts of wolfberry, 10 parts of dried ginger, 15 parts of red dates, and 10 parts of roasted liquorice.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The Chinese medicine composition is in oral dosage form.

5. The Chinese medicine composition according to claim 4, characterized in that: The oral dosage form is pill, tablet, capsule, granule, powder or oral solution.

6. The method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: include: The raw materials are pulverized separately and then mixed, or the raw materials are mixed and then pulverized to obtain a mixture; Alternatively, the raw materials are mixed and then extracted to obtain an extract.

7. The preparation method according to claim 6, characterized in that: Also includes: The mixture or the extract is added with pharmaceutically acceptable excipients to prepare an oral dosage form.

8. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for preventing, alleviating and / or treating degenerative lesions caused by spinal strain.

9. A drug for preventing, alleviating and / or treating spinal strain degenerative lesions, characterized in that: The active ingredients thereof include the traditional Chinese medicine composition according to any one of claims 1 to 5.