Low-irritation soothing botanical toner and method of making same

Abstract

The present application relates to the field of cosmetic technology, and particularly relates to a low-irritation soothing plant cosmetic lotion and a preparation method thereof.The low-irritation soothing plant cosmetic lotion comprises 80-95 parts of a solvent, 0.1-10 parts of a skin conditioning agent, 0.5-10 parts of a humectant, 0.01-1 parts of a chelating agent and 0.001-1 parts of a pH regulator; the skin conditioning agent comprises an active ingredient and a cactus extract compound in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid and glycolic acid; the cactus extract compound comprises an aggregate of cactus extract and cerium oxide particles doped with each other; and the cactus extract compound is prepared from cerium oxide and cactus extract in a mass ratio of 1:(1-50). The present application adds a specific skin conditioning agent, which can effectively reduce the irritation of active ingredients such as whitening agents and acids in the lotion to the skin.

Description

Low-irritant soothing plant-based toner and its preparation method Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a low-irritation soothing plant-based toner and its preparation method. Background Technology

[0002] Sensitive skin refers to a hyperresponsive state of the skin under physiological or pathological conditions. When stimulated by physical, chemical, or psychological factors, the skin is more prone to subjective symptoms such as burning, stinging, itching, and tightness, with or without objective signs such as erythema, scaling, and telangiectasia. The etiology and pathogenesis of sensitive skin are complex, with poor skincare habits and irritating substances added to cosmetics playing a major role. Surfactants, preservatives, fragrances, acids, and whitening agents in cosmetics are among the main factors inducing skin barrier dysfunction, skin irritation, and skin sensitivity. Irritants first damage the barrier function through the stratum corneum, simultaneously inducing the production of primary irritant factors in epidermal cells, which then activate dermal cells to produce a cascade amplification reaction, increasing sensory signal transmission and ultimately leading to various clinical symptoms such as dry skin, erythema, rashes, edema, itching, and pain.

[0003] Based on market research on soothing products, the demand for products for sensitive skin has increased significantly. However, product quality varies greatly, and many soothing products work after irritation has occurred, rarely addressing the protective effect against the irritant itself. Therefore, there is an urgent need to develop a toner that soothes the skin and reduces the irritation caused by cosmetic irritants.

[0004] In view of this, the present invention is hereby proposed. Summary of the Invention

[0005] One object of the present invention is to provide a low-irritant, soothing plant-based toner that can reduce the irritation of cosmetics themselves.

[0006] Another object of the present invention is to provide a method for preparing a low-irritant, soothing plant-based facial toner.

[0007] To achieve the above-mentioned objectives of the present invention, one aspect of the present invention provides a low-irritant soothing plant-based facial toner, comprising the following components in parts by weight:

[0008] The ingredients include 80-95 parts solvent, 0.1-10 parts skin conditioning agent, 0.5-10 parts moisturizer, 0.01-1 part chelating agent, and 0.001-1 part pH adjuster.

[0009] The skin conditioning agent comprises an active ingredient and a cactus extract complex in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid and glycolic acid; the cactus extract complex comprises aggregates of cactus extract and cerium oxide particles doped with the aggregates.

[0010] The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-50).

[0011] In a specific embodiment of the present invention, the mass ratio of the active ingredient to the cactus extract complex is (50-60):1.

[0012] In a specific embodiment of the present invention, the cactus extract complex is mainly prepared by the cactus extract in a mass ratio of 1:(1-20) of cerium oxide and cactus extract, preferably 1:(5-15).

[0013] In a specific embodiment of the present invention, the method for preparing the skin conditioning agent includes:

[0014] (a) Cerium oxide and cactus extract were co-precipitated, and the precipitate was collected; the precipitate was dissolved in water and freeze-dried to obtain freeze-dried powder;

[0015] (b) Mix the freeze-dried powder with the active ingredient in a certain proportion.

[0016] In a specific embodiment of the present invention, a cerium oxide dispersion is added to a solution of cactus extract to perform the coprecipitation.

[0017] In a specific embodiment of the present invention, the cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one selected from ethanol, methanol, and acetone. Further, in the cerium oxide dispersion, the mass ratio of cerium oxide to the solvent is 1:(1-500).

[0018] In a specific embodiment of the present invention, in step (a), the mass ratio of the precipitate to the water is 1:(8-12).

[0019] In a specific embodiment of the present invention, the solid content of the cactus extract solution is 3% to 5%. Further, the preparation of the cactus extract solution includes:

[0020] (1) The cactus was extracted with water. After the extraction was completed, the cactus was allowed to stand and age, and the supernatant was collected.

[0021] (2) Neutral protease and α-amylase were added to the supernatant for enzymatic extraction. After extraction, the enzymes were inactivated by heating.

[0022] (3) The enzyme-inactivated solution is decolorized and filtered, and then concentrated to obtain the cactus extract solution.

[0023] In a specific embodiment of the present invention, in step (1), the mass ratio of the water to the cactus is (20-50):1.

[0024] In a specific embodiment of the present invention, the amount of neutral protease used is 0.05% to 0.5% of the mass of the cactus in step (1).

[0025] In a specific embodiment of the present invention, the amount of α-amylase used is 0.05% to 0.5% of the mass of the supernatant.

[0026] In a specific embodiment of the present invention, step (2) includes: extracting at 40-80°C for 0.5-3 hours, and then heating to 50-85°C for 0.5-3 hours.

[0027] In a specific embodiment of the present invention, the solvent includes water.

[0028] In a specific embodiment of the present invention, the moisturizer includes butylene glycol and / or glycerin.

[0029] In a specific embodiment of the present invention, the chelating agent includes disodium EDTA.

[0030] In a specific embodiment of the present invention, the pH adjuster includes at least one of arginine, sodium hydroxide, and sodium citrate.

[0031] In a specific embodiment of the present invention, the lotion further includes a preservative. More specifically, it includes 0.1 to 5 parts by weight of preservative.

[0032] In a specific embodiment of the present invention, the preservative includes at least one selected from capryloyl hydroxamic acid, glyceryl caprylate, and 1,3-propanediol.

[0033] Another aspect of the present invention provides a method for preparing any of the above-described low-irritation soothing plant-based cosmetic waters, comprising the following steps:

[0034] (1) Mix the chelating agent with the solvent and heat to 82-85°C, then keep warm to obtain a chelating agent solution;

[0035] (2) When the chelating agent solution cools down to below 45°C, add skin conditioning agent and moisturizer, stir evenly, and then add pH adjuster to adjust pH to 5.5-6.5.

[0036] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0037] (1) The low-irritant soothing plant-based facial lotion of the present invention contains a specific skin conditioning agent, which can effectively reduce the irritation of the skin caused by active ingredients such as whitening agents and acids.

[0038] (2) The preparation method of the low-irritant soothing plant-based cosmetic water of the present invention is mild, easy to operate, and suitable for large-scale production. Attached Figure Description

[0039] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0040] Figure 1 shows SEM images of the skin conditioning agent (left) prepared in Example 1 of the present invention and the skin conditioning agent (right) prepared in Comparative Example 8.

[0041] Figure 2 shows the skin feel evaluation results of the toners provided in different embodiments and comparative examples of the present invention;

[0042] Figure 3 shows the skin itching sensation evaluation results of the toners provided in different embodiments and comparative examples of the present invention;

[0043] Figure 4 shows the skin stinging sensation evaluation results of the toners provided in different embodiments and comparative examples of the present invention;

[0044] Figure 5 shows the skin thermal sensation evaluation results of the toners provided in different embodiments and comparative examples of the present invention;

[0045] Figure 6 shows the evaluation results of skin itching sensation of the toners provided in different embodiments and comparative examples of the present invention;

[0046] Figure 7 shows the skin irritation evaluation results of the toners provided in different embodiments and comparative examples of the present invention. Detailed Implementation

[0047] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings and specific embodiments. However, those skilled in the art will understand that the embodiments described below are some embodiments of the present invention, but not all embodiments, and are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall be followed. Where the manufacturers of reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0048] This invention provides a low-irritant, soothing plant-based toner, comprising the following components by weight:

[0049] The ingredients include 80-95 parts solvent, 0.1-10 parts skin conditioning agent, 0.5-10 parts moisturizer, 0.01-1 part chelating agent, and 0.001-1 part pH adjuster.

[0050] The skin conditioning agent comprises an active ingredient and a cactus extract complex in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid and glycolic acid; the cactus extract complex comprises aggregates of cactus extract and cerium oxide particles inter-doped with the aggregates.

[0051] The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-50).

[0052] The skin conditioning agent used in the toner of this invention contains a cactus extract complex. The cactus extract encapsulates cerium oxide particles to form co-doped aggregates, which are then combined with active ingredients to reduce the irritation of the active ingredients to the skin. The cactus extract and cerium oxide form a dense protective film on the cell surface, which can encapsulate irritants and reduce their damage to cells.

[0053] In different embodiments, the mass ratio of the active ingredient to the cactus extract complex in the skin conditioning agent can be 40:1, 45:1, 50:1, 55:1, 60:1, 65:1, 70:1, or any combination thereof.

[0054] In different embodiments, the mass ratio of cerium oxide to cactus extract can be 1:1, 1:5, 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, or any combination thereof.

[0055] In the preparation of the cactus extract complex, the calculation of the mass ratio of cerium oxide to cactus extract is based on the solid content of cerium oxide and cactus extract, respectively.

[0056] In different implementation methods, the amounts of each component in the lotion, by weight, can be as follows:

[0057] The amount of solvent can be 80 parts, 82 parts, 85 parts, 88 parts, 90 parts, 92 parts, 95 parts, or any combination thereof;

[0058] The dosage of the skin conditioning agent can be 0.1 parts, 0.5 parts, 1 part, 2 parts, 5 parts, 8 parts, 10 parts, or any combination thereof;

[0059] The amount of moisturizer used can be 0.5 parts, 1 part, 2 parts, 5 parts, 8 parts, 10 parts, or any combination thereof;

[0060] The amount of chelating agent can be 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 part, or any combination thereof;

[0061] The amount of pH adjuster can be 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 part, or any combination thereof.

[0062] In a specific embodiment of the present invention, the mass ratio of the active ingredient to the cactus extract complex is (50-60):1.

[0063] In a specific embodiment of the present invention, the cactus extract complex is mainly prepared by cerium oxide and cactus extract in a mass ratio of 1:(1-20), preferably 1:(5-15).

[0064] In the cactus extract complex, cerium oxide particles may be partially doped on the surface of the aggregates. In the complex, cerium oxide particles are mainly doped inside the aggregates of cactus extract, such as ≥80%, ≥85%, ≥90%, or ≥95% of cerium oxide particles are doped inside the aggregates of cactus extract.

[0065] In a specific embodiment of the present invention, the method for preparing the skin conditioning agent includes:

[0066] (a) Cerium oxide and cactus extract were co-precipitated, and the precipitate was collected; the precipitate was dissolved in water and freeze-dried to obtain freeze-dried powder;

[0067] (b) Mix the freeze-dried powder with the active ingredient in a certain proportion.

[0068] In practice, in step (b), the lyophilized powder and active ingredient can be mixed by mechanical grinding or by stirring. The mixing time can be 5–20 minutes, but is not limited to this. Furthermore, the lyophilization process can be carried out in a conventional lyophilizer.

[0069] In a specific embodiment of the present invention, a cerium oxide dispersion is added to a solution of cactus extract for co-precipitation.

[0070] In a specific embodiment of the present invention, the cerium oxide dispersion comprises cerium oxide and a solvent; the solvent comprises at least one selected from ethanol, methanol, and acetone. Further, in the cerium oxide dispersion, the mass ratio of cerium oxide to solvent is 1:(1-500).

[0071] A cerium oxide dispersion is obtained by uniformly dispersing cerium oxide particles in a corresponding solvent. In different embodiments, the mass ratio of cerium oxide to solvent in the cerium oxide dispersion can be 1:1, 1:10, 1:50, 1:80, 1:100, 1:150, 1:200, 1:250, 1:300, 1:350, 1:400, 1:450, 1:500, or any combination thereof.

[0072] In a specific embodiment of the present invention, in step (a), the mass ratio of precipitate to water is 1:(8-12).

[0073] In different embodiments, in step (a), the mass ratio of precipitate to water can be 1:8, 1:9, 1:10, 1:11, 1:12, or any combination thereof.

[0074] In a specific embodiment of the present invention, the temperature of the cactus extract solution is 40–80°C; the temperature of the cerium oxide dispersion is 40–80°C.

[0075] In different embodiments, the cactus extract solution and cerium oxide dispersion can be preheated to 40°C, 45°C, 50°C, 55°C, 60°C, 65°C, 70°C, 75°C, 80°C, etc., before a mixed co-precipitation reaction is carried out.

[0076] In practice, the cactus extract solution is ultrasonically treated during the addition of the cerium oxide dispersion to ensure uniform mixing. The cerium oxide dispersion is preferably added dropwise.

[0077] In a specific embodiment of the present invention, the solid content in the cactus extract solution is 3% to 5%.

[0078] In different embodiments, the solid content in the cactus extract solution can be a range of 3%, 3.5%, 4%, 4.5%, 5%, or any combination thereof.

[0079] In a specific embodiment of the present invention, the preparation of the cactus extract solution includes:

[0080] (1) The cactus was extracted with water. After the extraction was completed, the cactus was allowed to stand and age, and the supernatant was collected.

[0081] (2) Add neutral protease and α-amylase to the supernatant for enzymatic extraction. After extraction, raise the temperature to inactivate the enzymes.

[0082] (3) The enzyme-inactivated solution was decolorized and filtered, and then concentrated to obtain a solution of cactus extract.

[0083] In a specific embodiment of the present invention, in step (1), the mass ratio of water to cactus is (20-50):1.

[0084] In different implementations, in step (1), the mass ratio of water to cactus can be 20:1, 25:1, 30:1, 35:1, 40:1, 45:1, 50:1, or any combination thereof.

[0085] In a specific embodiment of the present invention, step (1) includes: stirring and extracting at 40-80°C for 1-4 hours, and heating to 80-95°C and keeping warm for 10-40 minutes.

[0086] In different implementations, in step (1), the sample can be stirred and extracted at 40°C, 50°C, 60°C, 70°C or 80°C for 1h, 2h, 3h or 4h, and then heated to 80°C, 85°C, 90°C or 95°C and kept warm for 10min, 20min, 30min or 40min.

[0087] In a specific embodiment of the present invention, the settling and aging time is 12 to 18 hours.

[0088] In different implementation methods, the settling and aging time can be 12h, 14h, 15h, 16h, 18h, or any combination thereof. Settling and aging allows starchy components in the system to crystallize and precipitate, removing starchy components from the extract and improving the stability of the extract.

[0089] In a specific embodiment of the present invention, the amount of neutral protease used is 0.05% to 0.5% of the mass of the cactus in step (1); the amount of α-amylase used is 0.05% to 0.5% of the mass of the supernatant.

[0090] In different embodiments, the amount of neutral protease can be 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% of the mass of the plant material in step (1), or any combination thereof; the amount of α-amylase can be 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% of the mass of the supernatant, or any combination thereof.

[0091] In a specific embodiment of the present invention, step (2) includes: extracting at 40-80°C for 0.5-3 hours, and then heating to 50-85°C for 0.5-3 hours.

[0092] In different embodiments, step (2) of enzymatic extraction may include: first, stirring and extracting at 40℃, 50℃, 60℃, 70℃ or 80℃ for 0.5h, 1h, 2h or 3h, and then heating to 50℃, 60℃, 70℃, 80℃ or 85℃ for 0.5h, 1h, 2h or 3h. The extraction temperature after heating is higher than the previous extraction temperature.

[0093] In a specific embodiment of the present invention, the enzyme inactivation by heating includes: treating at 95-100°C for 30-40 minutes.

[0094] In a specific embodiment of the present invention, activated carbon is used for decolorization. Further, the decolorization includes: cooling the enzyme-inactivated solution to 65-70°C, adding 0.1wt%-10wt% activated carbon to the enzyme-inactivated solution, continuing to heat to 80-85°C and holding for 1-1.5 hours, and then cooling to 60-65°C.

[0095] In different embodiments, the amount of activated carbon used can be 0.1 wt%, 0.5 wt%, 1 wt%, 2 wt%, 5 wt%, 8 wt%, 10 wt%, or any combination thereof, of the enzyme-inactivated solution.

[0096] In a specific embodiment of the present invention, the filtration process includes: filtering the decolorized material through paperboard and / or diatomaceous earth. For example, 0.3-50μm paperboard and / or diatomaceous earth BS10# can be used for filtration.

[0097] In a specific embodiment of the present invention, the solvent includes water.

[0098] In a specific embodiment of the present invention, the moisturizer includes butylene glycol and / or glycerin.

[0099] In a specific embodiment of the present invention, the chelating agent includes disodium EDTA.

[0100] In a specific embodiment of the present invention, the pH adjuster includes at least one of arginine, sodium hydroxide, and sodium citrate.

[0101] In a specific embodiment of the present invention, the lotion further includes a preservative. More specifically, it includes 0.1 to 5 parts by weight of preservative.

[0102] In a specific embodiment of the present invention, the preservative includes at least one selected from capryloyl hydroxamic acid, glyceryl caprylate, and 1,3-propanediol.

[0103] Another aspect of the present invention provides a method for preparing any of the above-described low-irritation soothing plant-based cosmetic waters, comprising the following steps:

[0104] (1) Mix the chelating agent with the solvent and heat to 82-85°C, then keep warm to obtain a chelating agent solution;

[0105] (2) When the chelating agent solution cools down to below 45°C, add skin conditioning agent and moisturizer, stir evenly, and then add pH adjuster to adjust pH to 5.5-6.5.

[0106] If a toner contains preservatives, the preservatives can be added after the moisturizer.

[0107] Example 1

[0108] This embodiment provides a method for preparing a low-irritation, soothing plant-based toner, comprising the following steps:

[0109] (1) Mix 0.05 parts by weight of disodium EDTA and 88.336 parts by weight of water, stir and heat to 82-85°C, stir until completely transparent, keep warm for 20-30 minutes to sterilize, defoam and cool down;

[0110] (2) When the solution in step (1) cools down to below 45°C, add 6.1 parts by weight of skin conditioning agent, 5 parts by weight of butylene glycol, and 0.5 parts by weight of preservative in sequence, stir thoroughly, and then add 0.014 parts by weight of arginine to adjust the pH to 5.5-6.5. The preservative includes capryloyl hydroxamic acid, glyceryl caprylate, and 1,3-propanediol in a mass ratio of 0.03:0.02:0.45.

[0111] The preparation methods for skin conditioning agents include:

[0112] (a) Take the stem of the Prunus persica and crush it, then pass it through a 60-mesh sieve; then take the crushed Prunus persica stem powder, add purified water at a material-to-liquid ratio of 1:20 (m:m), heat to 50-55℃ and stir to extract for 2 hours, then heat to 82±2℃ and keep warm for 20 minutes, turn off the stirring and let it stand for 15 hours to age.

[0113] (b) Take the supernatant of the material after standing and aging in step (a) and weigh it. Add 0.2 wt% of neutral protease based on the weight of the Prickly Pear Cactus stem powder used in step (a) and 0.1 wt% of α-amylase based on the weight of the supernatant. Then heat to 52±2℃ and stir to extract for 1 h, and then heat to 82±2℃ and stir to extract for 1 h.

[0114] (c) Heat the material extracted in step (b) to 95-100°C and stir for 30 minutes to complete enzyme inactivation; then cool down to 70°C, start stirring, add activated carbon at 1 wt% of the material mass, then heat to 82±2°C and keep warm for 1 hour, then cool down to 62±2°C.

[0115] (d) The material processed in step (3) is added to diatomaceous earth BS10# for filtration to obtain coarse filtrate; then, conventional vacuum concentration is used to concentrate it to a solid content of 5% to obtain a cactus extract solution.

[0116] (e) Weigh cerium oxide according to the mass ratio of cerium oxide to cactus extract obtained in step (d) (calculated based on the solid content of the solution obtained in step (4) being 5%), and then add anhydrous ethanol with a mass of 400 times that of cerium oxide to the cerium oxide and stir evenly to obtain cerium oxide ethanol dispersion.

[0117] (f) Heat the cactus extract solution from step (d) and the cerium oxide ethanol dispersion from step (e) to 60°C. Under ultrasonic conditions (ultrasonic power of 100W and ultrasonic temperature of 60°C), add the cerium oxide ethanol dispersion dropwise to the cactus extract solution at 60°C. After the addition is complete, the addition rate is 2-3 drops / s. Centrifuge at 5000 rpm for 20 min and collect the lower precipitate. Dissolve the precipitate in 10 times its weight of purified water and then perform conventional freeze-drying to obtain the cactus extract complex.

[0118] (g) Weigh out glycolic acid and cactus extract complex at a mass ratio of 60:1, mix and grind them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0119] Example 2

[0120] Example 2 is the same as Example 1, except that the skin conditioning agent and the dosage are different.

[0121] The amount of skin conditioning agent used is 5.1 parts by weight, and the amount of water used is 89.336 parts by weight.

[0122] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 1, except that step (g) is different.

[0123] Step (g) of this embodiment includes: weighing nicotinamide and cactus extract complex at a mass ratio of 50:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0124] Example 3

[0125] Example 3 is the same as Example 2, except that the skin conditioning agent is different.

[0126] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 2, except that step (g) is different.

[0127] Step (g) of this embodiment includes: weighing 377 and cactus extract complex at a mass ratio of 50:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0128] Example 4

[0129] Example 4 is the same as Example 2, except that the skin conditioning agent is different.

[0130] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 2, except that step (g) is different.

[0131] Step (g) of this embodiment includes: weighing arbutin and cactus extract complex at a mass ratio of 50:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0132] Example 5

[0133] Example 5 is the same as Example 2, except that the skin conditioning agent is different.

[0134] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 2, except that step (g) is different.

[0135] Step (g) of this embodiment includes: weighing kojic acid and cactus extract complex at a mass ratio of 50:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0136] Example 6

[0137] Example 6 is the same as Example 1, except that the skin conditioning agent is different.

[0138] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 1, except that step (g) is different.

[0139] Step (g) of this embodiment includes: weighing glycolic acid and cactus extract complex at a mass ratio of 40:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0140] Example 7

[0141] Example 7 is the same as Example 1, except that the skin conditioning agent is different.

[0142] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 1, except that step (g) is different.

[0143] Step (g) of this embodiment includes: weighing glycolic acid and cactus extract complex at a mass ratio of 70:1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain a skin conditioning agent.

[0144] Example 8

[0145] Example 8 is the same as Example 1, except that the skin conditioning agent is different.

[0146] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 1, except that step (e) is different.

[0147] Step (e) of this embodiment includes: weighing cerium oxide according to a mass ratio of cerium oxide to cactus extract obtained in step (d) of 1:1, then adding anhydrous ethanol at a mass of 400 times the mass of cerium oxide to the cerium oxide, and stirring evenly to obtain a cerium oxide ethanol dispersion.

[0148] Example 9

[0149] Example 9 is the same as Example 1, except that the skin conditioning agent is different.

[0150] The preparation of the skin conditioning agent in this embodiment is the same as that in Example 1, except that step (e) is different.

[0151] Step (e) of this embodiment includes: weighing cerium oxide according to a mass ratio of cerium oxide to cactus extract obtained in step (d) of 1:50, then adding anhydrous ethanol at a mass of 400 times the mass of cerium oxide to the cerium oxide, and stirring evenly to obtain a cerium oxide ethanol dispersion.

[0152] Examples 10-13

[0153] This embodiment provides a method for preparing a low-irritation, soothing plant-based toner, comprising the following steps:

[0154] (1) Mix the chelating agent and water, heat to 82-85°C, stir until completely transparent, keep warm for 20-30 minutes for disinfection, defoaming and cooling;

[0155] (2) When the solution in step (1) cools down to below 45°C, add skin conditioning agent, moisturizer and preservative in sequence, stir thoroughly, and then add pH adjuster to adjust pH to 5.5 to 6.5.

[0156] The types and amounts of each component are shown in Table 1.

[0157] Table 1. Raw material composition (parts by weight) of different toners

[0158]

[0159] Comparative Example 1

[0160] Comparative Example 1 uses the same preparation method as Example 1, except that the skin conditioning agent is different and the amount used is different.

[0161] The amount of skin conditioning agent used is 6 parts by weight, and the amount of water used is 88.436 parts by weight.

[0162] The skin conditioning agent in Comparative Example 1 was glycolic acid.

[0163] Comparative Example 2

[0164] Comparative Example 2 uses the same preparation method as Example 2, except that the skin conditioning agent is different and the amount used is different.

[0165] The amount of skin conditioning agent used is 5 parts by weight, and the amount of water used is 89.436 parts by weight.

[0166] The skin conditioning agent in Comparative Example 2 was niacinamide.

[0167] Comparative Example 3

[0168] Comparative Example 3 was prepared using the same method as Example 1, except that it did not include a skin conditioning agent and the amount of water used was 94.436 parts by weight.

[0169] Comparative Example 4

[0170] Comparative Example 4 uses the same preparation method as Example 1, except that the skin conditioning agent is different.

[0171] The preparation of the skin conditioning agent includes: weighing glycolic acid and cactus extract at a mass ratio of 6.6:0.1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain the skin conditioning agent.

[0172] The preparation of cactus extract includes:

[0173] (1) Take the stem of the Prunus persica and crush it, then pass it through a 60-mesh sieve. Then take the crushed Prunus persica stem powder, add purified water at a material-to-liquid ratio of 1:20 (m:m), heat to 50-55℃ and stir to extract for 2 hours, then heat to 82±2℃ and keep warm for 20 minutes, turn off the stirring and let it stand for 15 hours to age.

[0174] (2) Take the supernatant of the material after standing and aging in step (1) and weigh it. Add 0.2wt% of neutral protease based on the weight of the Prunus persica stem powder used in step (1) and 0.1wt% of α-amylase based on the weight of the supernatant. Then heat to 52±2℃ and stir to extract for 1h, and then heat to 82±2℃ and stir to extract for 1h.

[0175] (3) Heat the material extracted in step (2) to 95-100℃, heat and stir for 30 minutes to complete enzyme inactivation; then cool down to 70℃, start stirring, add activated carbon at 1wt% of the material mass, then heat to 82±2℃ and keep warm for 1 hour, then cool down to 62±2℃.

[0176] (4) Add the material processed in step (3) to diatomaceous earth BS10# filter to obtain coarse filtrate; then use conventional vacuum concentration operation to concentrate to a solid content of 5% to obtain a cactus extract solution.

[0177] (5) Add 95% ethanol aqueous solution to the cactus extract solution in step (4) until the mass fraction of ethanol in the mixed system reaches 80%, then centrifuge to collect the lower precipitate and dry it.

[0178] (6) Dissolve the solid obtained by drying in step (5) in 10 times its weight of purified water, and then freeze-dry it to obtain cactus extract.

[0179] Comparative Example 5

[0180] Comparative Example 5 was prepared using the same method as Example 1, except that the skin conditioning agent was different.

[0181] The preparation of the skin conditioning agent includes: weighing glycolic acid and cerium oxide particles at a mass ratio of 6.6:0.01, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain the skin conditioning agent.

[0182] Comparative Example 6

[0183] Comparative Example 6 uses the same preparation method as Example 1, except that the skin conditioning agent is different and the amounts of skin conditioning agent and water are different.

[0184] The amount of skin conditioning agent used is 5.1 parts by weight, and the amount of water used is 89.336 parts by weight.

[0185] The preparation of the skin conditioning agent includes: weighing nicotinamide and cactus extract at a mass ratio of 5.5:0.1, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain the skin conditioning agent.

[0186] The preparation of cactus extract was the same as in comparative example 4.

[0187] Comparative Example 7

[0188] Comparative Example 7 was prepared using the same method as Example 1, except that the skin conditioning agent was different and the amounts of skin conditioning agent and water were different.

[0189] The amount of skin conditioning agent used is 5.1 parts by weight, and the amount of water used is 89.336 parts by weight.

[0190] The preparation of the skin conditioning agent includes: weighing nicotinamide and cerium oxide particles at a mass ratio of 5.5:0.01, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain the skin conditioning agent.

[0191] Comparative Example 8

[0192] Comparative Example 8 was prepared using the same method as Example 1, except that the skin conditioning agent was different.

[0193] The preparation of the skin conditioning agent includes: weighing glycolic acid, cactus extract obtained from Comparative Example 4, and cerium oxide particles in a mass ratio of 6.6:0.1:0.01, mixing and grinding them in a mortar for 10 minutes at room temperature to obtain the skin conditioning agent.

[0194] Experimental Example 1

[0195] Figure 1 shows SEM images of the skin conditioning agent of Example 1 and the skin conditioning agent of Comparative Example 8. As can be seen from the figure, in the skin conditioning agent prepared by the method of Comparative Example 8 (left), cerium oxide particles are distributed on the outer side of the cactus extract aggregates and are scattered on its surface; while in the skin conditioning agent prepared by the method of Example 1 of this invention (right), cerium oxide particles can be well aggregated inside the cactus extract aggregates, resulting in a stable co-doped skin conditioning agent.

[0196] Experiment Example 2

[0197] The system stability of the toners prepared in different embodiments and comparative examples was observed.

[0198] The skin feel evaluation results of the toners prepared in different embodiments and comparative examples are shown in Figure 2. The skin feel evaluation method included: selecting 6 volunteers, applying the toners of Embodiment 1, Comparative Example 1, Comparative Example 5, and Comparative Example 8 to the left and right sides of the subjects respectively, and having the subjects subjectively evaluate the moisturizing, soft, refreshing, smooth, and sticky feeling, and scoring them on a 5-point scale (0 points for no feeling, 1 point for slight feeling, 2 points for mild feeling, 3 points for moderate feeling, and 4 points for severe feeling). The test results are shown in Figure 2.

[0199] Experimental Example 3

[0200] Simultaneously, masks soaked in 50 μL of the following masks (Examples 1, 1, 4, 5, and 8) were applied to both sides of the nasolabial folds of the subjects (cut into squares, approximately 1.5 cm in length and width). Subjects subjectively evaluated the itching and stinging sensations in the nasolabial folds at 0 min, 1 min, 3 min, 5 min, 8 min, 10 min, 15 min, and 30 min after use. The test results, comparing the degree of stimulation between samples (scoring dimensions: 0-3 points, minimum scoring unit 0.1 points, no sensation: 0 points, slight sensation: 1 point, noticeable sensation: 2 points, severe stimulation: 3 points), are shown in Figures 3 and 4.

[0201] As can be seen from the figure, Embodiment 1 of the present invention can effectively antagonize the skin irritation caused by glycolic acid and has a significant soothing effect.

[0202] 0.2g of the sample from Examples 2, 2, 6, and 7 was applied to the left and right sides of the subjects' faces, respectively. Timing was started, and the subjects were asked to subjectively evaluate the sensations of heat, itching, and tingling at 0 min, 1 min, 3 min, 5 min, 8 min, 15 min, and 30 min after stimulation. The scores were given using a 4-point scale (0 points for no sensation, 1 point for mild sensation, 2 points for moderate sensation, and 3 points for severe sensation). The experimental results are shown in Figures 5 to 7.

[0203] As can be seen from the figure, Example 2 of the present invention can significantly alleviate the skin irritation caused by niacinamide and has a good soothing effect.

[0204] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A low-irritation, soothing plant-based toner, characterized in that: The product comprises, by weight, the following components: 80-95 parts solvent, 0.1-10 parts skin conditioning agent, 0.5-10 parts moisturizer, 0.01-1 part chelating agent, and 0.001-1 part pH adjuster; the skin conditioning agent comprises an active ingredient and a cactus extract complex in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid, and glycolic acid; the cactus extract complex comprises aggregates of cactus extract and cerium oxide particles doped with the aggregates; the cactus extract complex is mainly prepared from cerium oxide and cactus extract in a mass ratio of 1:(1-50); The preparation of the cactus extract complex includes: adding a cerium oxide dispersion to a cactus extract solution for co-precipitation and collecting the precipitate; dissolving the precipitate in water, freeze-drying it, and collecting the freeze-dried powder; during the addition of the cerium oxide dispersion, the cactus extract solution is subjected to ultrasonic treatment; the temperature of the cactus extract solution is 40-80℃, and the temperature of the cerium oxide dispersion is 40-80℃; the cerium oxide dispersion includes cerium oxide and a solvent in a mass ratio of 1:(1-500), and the solvent includes at least one of ethanol, methanol, and acetone; the preparation of the cactus extract solution includes: (1) extracting the cactus with water, allowing it to stand and age after extraction, and collecting the supernatant; (2) adding neutral protease and α-amylase to the supernatant for enzymatic extraction, and heating to inactivate the enzymes after extraction; (3) decolorizing and filtering the enzyme-inactivated solution, and then concentrating it to obtain the cactus extract solution.

2. The low-irritation soothing plant-based toner according to claim 1, characterized in that, The mass ratio of the active ingredient to the cactus extract complex is (50-60):

1.

3. The low-irritation soothing plant-based toner according to claim 1, characterized in that, The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(1-20).

4. The low-irritation soothing plant-based toner according to claim 1, characterized in that, The cactus extract complex is mainly prepared by combining cerium oxide and cactus extract in a mass ratio of 1:(5-15).

5. The low-irritation soothing plant-based toner according to claim 1, characterized in that, The preparation method of the skin conditioning agent includes: mixing the freeze-dried powder with the active ingredients in a certain proportion.

6. The low-irritation soothing plant-based toner according to claim 1, characterized in that, The precipitate is dissolved in water, and the mass ratio of the precipitate to the water is 1:(8-12); and / or, the solid content in the solution of the cactus extract is 3%-5%.

7. The low-irritation soothing plant-based toner according to claim 1, characterized in that, In step (1), the mass ratio of water to cactus is (20-50):1; and / or, the amount of neutral protease used is 0.05%-0.5% of the mass of cactus in step (1); and / or, the amount of α-amylase used is 0.05%-0.5% of the mass of the supernatant; and / or, in step (2), the enzymatic extraction includes: extraction at 40-80℃ for 0.5-3h, and extraction at 50-85℃ for 0.5-3h.

8. The low-irritation soothing plant-based toner according to claim 1, characterized in that, It has at least one of the following characteristics: (1) the solvent includes water; (2) the humectant includes butylene glycol and / or glycerin; (3) the chelating agent includes disodium EDTA; and (4) the pH adjuster includes at least one of arginine, sodium hydroxide and sodium citrate.

9. The low-irritation soothing plant-based toner according to claim 1, characterized in that, It also includes preservatives.

10. The low-irritation soothing plant-based toner according to claim 9, characterized in that, It includes 0.1 to 5 parts by weight of preservative; said preservative includes at least one of capryloyl hydroxamic acid, glyceryl caprylate and 1,3-propanediol.

11. A method for preparing the low-irritation soothing plant-based facial toner according to any one of claims 1 to 10, characterized in that, The process includes the following steps: (1) mixing the chelating agent with the solvent and heating to 82-85°C, and keeping warm to obtain a chelating agent solution; (2) when the chelating agent solution cools down to below 45°C, adding a skin conditioning agent and a moisturizing agent, stirring evenly, and then adding a pH adjuster to adjust the pH to 5.5-6.5.

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