Multi-beam vector orthogonal type ultrasonic penetration system

Abstract

The application provides a multi-sound beam vector orthogonal type ultrasonic penetration promoting system, belonging to the field of ultrasonic penetration promotion, and the system comprises a treatment head, a control component, an ultrasonic transducer base, a central ultrasonic transducer and a plurality of edge ultrasonic transducers; the plurality of edge ultrasonic transducers are distributed at edge positions of the ultrasonic transducer base; the central ultrasonic transducer is located at a central position of the plurality of edge ultrasonic transducers; the central ultrasonic transducer is used for emitting a first ultrasonic wave to a target medium; each edge ultrasonic transducer is used for emitting a second ultrasonic wave to the target medium; the direction of the first ultrasonic wave is orthogonal to the direction of the second ultrasonic wave, and the frequency of the first ultrasonic wave is smaller than the frequency of the second ultrasonic wave; and the control component is used for controlling the duty cycle and the working sequence of the central ultrasonic transducer and each edge ultrasonic transducer according to a penetration promoting mode selected by a user. The application improves the penetration promoting effect, avoids the damage of the target medium, and improves the safety of ultrasonic penetration promotion.

Description

Technical Field

[0001] This invention relates to the field of ultrasonic permeation, and in particular to a multi-beam vector orthogonal ultrasonic permeation system. Background Technology

[0002] Sound waves with frequencies higher than 20kHz are called ultrasound. Ultrasound has excellent directionality and penetrating power, making it particularly useful in medicine for imaging, ablation procedures, and cell massage. Ultrasonic cavitation is a common injection method in the medical drug delivery industry, and ultrasound-assisted transdermal drug delivery has been studied for decades. Initially, research in this field focused on using high-frequency ultrasound (specifically, ultrasound with frequencies greater than 0.7MHz) to allow active drug components to penetrate the skin. Ultrasonic cavitation refers to the dynamic process of micro-cavitation bubbles in a liquid vibrating under the influence of sound waves, and then growing and collapsing when the sound pressure reaches a certain value. When ultrasound acts on a liquid, it can generate a large number of small bubbles. One reason is that local tensile stress in the liquid creates negative pressure, causing the gas originally dissolved in the liquid to become supersaturated and escape as small bubbles. Another reason is that the strong tensile stress "tears" the liquid open, creating a cavity, a process known as cavitation.

[0003] In the early 1990s, low-frequency ultrasound (specifically, frequencies less than 100 kHz) was also extensively studied in the field of transdermal drug delivery. Under the influence of high-frequency ultrasound, the key to drug penetration through the skin lies in the cavitation effect of ultrasound within the skin tissue. Simultaneously, the micro-fluidic action of low-frequency ultrasound on the skin surface can increase its permeability and deliver various drugs. Low-frequency ultrasound can enhance the transdermal transport efficacy of various low-molecular-weight drugs and high-molecular-weight protein drugs.

[0004] In the medical field, among technologies involving transdermal penetration of active ingredients, ultrasonic cavitation technology is a mature and effective method for promoting the transdermal penetration of small molecule components. However, when promoting deep penetration of large molecule active ingredients, the methods often involve extending the duration of ultrasound or increasing the sound pressure intensity. This single-frequency ultrasonic cavitation cannot accurately deliver large molecule active ingredients to the required depth. Furthermore, extending or intensifying the ultrasound action can cause skin heating, leading to irreversible skin damage and a poor user experience. Summary of the Invention

[0005] The purpose of this invention is to provide a multi-beam vector orthogonal ultrasonic permeation system that can improve the permeation effect while enhancing the safety of permeation.

[0006] To achieve the above objectives, the present invention provides the following solution:

[0007] A multi-beam vector orthogonal ultrasound permeation enhancement system includes: a treatment head, a control unit, an ultrasound transducer base, a central ultrasound transducer, and multiple peripheral ultrasound transducers;

[0008] Multiple peripheral ultrasound transducers are distributed at the edge of the ultrasound transducer base; the central ultrasound transducer is located at the center of the multiple peripheral ultrasound transducers, and both the central ultrasound transducer and each peripheral ultrasound transducer are fixed to the treatment head.

[0009] The central ultrasonic transducer is used to emit a first ultrasonic wave toward the target medium; each edge ultrasonic transducer is used to emit a second ultrasonic wave toward the target medium; the direction of the first ultrasonic wave is orthogonal to the direction of the second ultrasonic wave, and the frequency of the first ultrasonic wave is less than the frequency of the second ultrasonic wave.

[0010] The control unit is connected to the central ultrasonic transducer and each edge ultrasonic transducer respectively. The control unit is used to control the duty cycle and working sequence of the central ultrasonic transducer and each edge ultrasonic transducer according to the permeation mode selected by the user.

[0011] Optionally, the treatment head is filled with an acoustic coupling medium.

[0012] Optionally, the direction of the first ultrasound wave is parallel to the treatment head; the direction of the second ultrasound wave is perpendicular to the extension of the tangent of the treatment head.

[0013] Optionally, the frequency range of the first ultrasonic wave is 20kHz to 40kHz; the frequency range of the second ultrasonic wave is 1MHz to 3MHz.

[0014] Optionally, the ultrasonic energy range of the first ultrasonic wave is 0.1–0.3 mW / cm². 2 The second ultrasonic wave has an ultrasonic energy range of 0.2–0.5 mW / cm². 2 .

[0015] Optionally, the control component includes:

[0016] The central processing unit is used to generate central control signals and edge control signals according to the permeation mode selected by the user;

[0017] A central ultrasound control module is connected to the central processor and the central ultrasound transducer respectively, and is used to control the duty cycle of the central ultrasound transducer according to the central control signal.

[0018] The edge ultrasound control module is connected to the central processing unit and each edge ultrasound transducer, and is used to control the duty cycle and working sequence of each edge ultrasound transducer according to the edge control signal.

[0019] Optionally, the number of edge ultrasonic transducers is four, namely: a first edge ultrasonic transducer, a second edge ultrasonic transducer, a third edge ultrasonic transducer, and a fourth edge ultrasonic transducer; the four edge ultrasonic transducers are arranged counterclockwise along the edge of the ultrasonic transducer base as the first edge ultrasonic transducer, the second edge ultrasonic transducer, the fourth edge ultrasonic transducer, and the third edge ultrasonic transducer.

[0020] Optionally, the infiltration-enhancing mode includes a first infiltration-enhancing mode, a second infiltration-enhancing mode, and a third infiltration-enhancing mode;

[0021] When the first permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer to be 0, and sequentially controls the first edge ultrasonic transducer, the second edge ultrasonic transducer, the third edge ultrasonic transducer, and the fourth edge ultrasonic transducer to work according to a set time interval; the duty cycle of each edge ultrasonic transducer is 25%.

[0022] When the second permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer to be 0, and sequentially controls the first group of edge ultrasonic transducers and the second group of edge ultrasonic transducers to work according to a set time interval; the duty cycle of each group of edge ultrasonic transducers is 50%; the first group of edge ultrasonic transducers includes a first edge ultrasonic transducer and a third edge ultrasonic transducer; the second group of edge ultrasonic transducers includes a second edge ultrasonic transducer and a fourth edge ultrasonic transducer;

[0023] When the third permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer and each peripheral ultrasonic transducer to be 0.

[0024] Optionally, when selecting the first permeation-enhancing mode, the energy transferred by the multi-beam vector orthogonal ultrasonic permeation-enhancing system to the target medium is:

[0025] When the second permeation-enhancing mode is selected, the energy transferred to the target medium by the multi-beam vector orthogonal ultrasonic permeation-enhancing system is:

[0026] When selecting the third infiltration enhancement mode, the energy transferred to the target medium by the multi-beam vector orthogonal ultrasonic infiltration enhancement system is:

[0027] Where E is the energy transferred from the multi-beam vector orthogonal ultrasonic permeation system to the target medium, and P L0 P represents the acoustic pressure energy amplitude of the central ultrasonic transducer. H0 The amplitude of the acoustic pressure energy of each edge ultrasonic transducer.

[0028] According to specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0029] This invention places multiple edge ultrasonic transducers (high-frequency ultrasonic transducers) at the edges of the ultrasonic transducer base, and places a central ultrasonic transducer (low-frequency ultrasonic transducer) at the center of the multiple edge ultrasonic transducers. The control unit controls the duty cycle and working sequence of the central ultrasonic transducer and each edge ultrasonic transducer according to the permeation mode selected by the user, so that the central ultrasonic transducer and each edge ultrasonic transducer emit low-frequency and high-frequency ultrasonic waves in orthogonal directions towards the target medium, thereby improving the permeation effect, avoiding damage to the target medium, and improving the safety of ultrasonic permeation. Attached Figure Description

[0030] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0031] Figure 1 A schematic diagram of the multi-beam vector orthogonal ultrasonic permeation enhancement system provided by the present invention;

[0032] Figure 2 A three-dimensional schematic diagram showing the positional relationship of the ultrasonic transducers;

[0033] Figure 3 This is a planar schematic diagram showing the positional relationship of the ultrasonic transducers;

[0034] Figure 4 This is a schematic diagram illustrating the working process of the multi-beam vector orthogonal ultrasonic permeation system provided by the present invention.

[0035] Symbol explanation:

[0036] 1-Treatment surface, 2-Treatment head, 3-Ultrasonic transducer base, 4-Central ultrasonic transducer, 5-Edge ultrasonic transducer, 6-Central processor, 7-Central ultrasonic control module, 8-Edge ultrasonic control module, 9-Power supply equipment, 10-First edge ultrasonic transducer, 11-Second edge ultrasonic transducer, 12-Third edge ultrasonic transducer, 13-Fourth edge ultrasonic transducer. Detailed Implementation

[0037] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] The purpose of this invention is to provide a multi-beam vector orthogonal ultrasound penetration-enhancing system that combines the advantages of high-frequency and low-frequency ultrasound. During cosmetic procedures, the frequency of high-frequency ultrasound is adjusted according to the specific active ingredient to create suitable cavitation bubbles. Simultaneously, low-frequency ultrasound provides micro-fluidic penetration enhancement to the skin surface. By adaptively and continuously adjusting the duration and range of low-frequency ultrasound, the microbubbles cavitated by high-frequency ultrasound are further enhanced by low-frequency flow, increasing the skin's ability to transport specific low-molecular-weight drugs or high-molecular-weight proteins, thereby improving the absorption of active ingredients at the target site and forming a combined penetration enhancement. Without prolonging the ultrasound's duration and intensity, this significantly improves the penetration ability of ultrasound technology for active ingredients on the skin surface. It not only reduces the harmful and uncomfortable effects of prolonged ultrasound exposure and biothermal effects, avoiding irreversible damage to the skin surface, but also enhances the absorption of active ingredients at the target site, greatly improving the cosmetic effect.

[0039] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] like Figure 1 As shown, the multi-beam vector orthogonal ultrasound permeation system provided by the present invention includes: a treatment head 2, a control component, an ultrasound transducer base 3, a central ultrasound transducer 4, and multiple peripheral ultrasound transducers 5.

[0041] The treatment head 2 is filled with an acoustic coupling medium. During operation, the treatment surface 1 on the treatment head 2 contacts the target medium. The central ultrasound transducer 4 is the low-frequency ultrasound transducer, and the peripheral ultrasound transducer 5 is the high-frequency ultrasound transducer.

[0042] Multiple peripheral ultrasound transducers 5 are distributed at the edges of the ultrasound transducer base 3. The central ultrasound transducer 4 is located at the center of the multiple peripheral ultrasound transducers 5, and both the central ultrasound transducer 4 and each peripheral ultrasound transducer 5 are fixed to the treatment head 2.

[0043] The central ultrasonic transducer 4 is used to emit a first ultrasonic wave toward the target medium. Each peripheral ultrasonic transducer 5 is used to emit a second ultrasonic wave toward the target medium. The direction of the first ultrasonic wave is orthogonal to the direction of the second ultrasonic wave, and the frequency of the first ultrasonic wave is less than the frequency of the second ultrasonic wave. The target medium is skin.

[0044] In one specific implementation, the direction of the first ultrasonic wave is parallel to the treatment head 2. The direction of the second ultrasonic wave is perpendicular to the extension of the tangent of the treatment head 2, thereby achieving orthogonality between the low-frequency and high-frequency ultrasonic waves.

[0045] In one specific implementation, the central ultrasound transducer 4 is used to emit low-frequency ultrasound waves perpendicular to the tissue surface, and each peripheral ultrasound transducer 5 is used to emit high-frequency ultrasound waves parallel to the tissue surface.

[0046] The first ultrasonic wave has a frequency range of 20 kHz to 40 kHz. The second ultrasonic wave has a frequency range of 1 MHz to 3 MHz. The ultrasonic energy of the first ultrasonic wave ranges from 0.1 to 0.3 mW / cm². 2 The second ultrasonic wave has an ultrasonic energy range of 0.2–0.5 mW / cm². 2 .

[0047] In this embodiment, as Figure 2 and Figure 3 As shown, there are four edge ultrasonic transducers 5, namely: a first edge ultrasonic transducer 10, a second edge ultrasonic transducer 11, a third edge ultrasonic transducer 12, and a fourth edge ultrasonic transducer 13. The four edge ultrasonic transducers 5 are arranged counterclockwise along the edge of the ultrasonic transducer base 3 as the first edge ultrasonic transducer 10, the second edge ultrasonic transducer 11, the fourth edge ultrasonic transducer 13, and the third edge ultrasonic transducer 12.

[0048] The control unit is connected to the central ultrasonic transducer 4 and each edge ultrasonic transducer 5 respectively. The control unit is used to control the duty cycle and working sequence of the central ultrasonic transducer 4 and each edge ultrasonic transducer 5 according to the permeation mode selected by the user.

[0049] Specifically, the control components include: a central processing unit 6, a central ultrasound control module 7, and an edge ultrasound control module 8.

[0050] The central processing unit 6 is used to generate central control signals and edge control signals according to the permeation mode selected by the user.

[0051] The central ultrasound control module 7 is connected to the central processor 6 and the central ultrasound transducer 4 respectively. The central ultrasound control module 7 is used to control the duty cycle of the central ultrasound transducer 4 according to the central control signal.

[0052] The edge ultrasound control module 8 is connected to the central processing unit 6 and each edge ultrasound transducer 5 respectively. The edge ultrasound control module 8 is used to control the duty cycle and working sequence of each edge ultrasound transducer 5 according to the edge control signal.

[0053] Specifically, both the central ultrasonic control module 7 and the peripheral ultrasonic control module 8 are fixed to the ultrasonic transducer base 3.

[0054] As one specific implementation method, the permeation-enhancing modes include a first permeation-enhancing mode, a second permeation-enhancing mode, and a third permeation-enhancing mode. This invention achieves different degrees of permeation-enhancing effects through these three permeation-enhancing modes.

[0055] When the first permeation-enhancing mode is selected, the control component controls the working duty cycle of the central ultrasonic transducer 4 to be 0, and controls the first edge ultrasonic transducer 10, the second edge ultrasonic transducer 11, the third edge ultrasonic transducer 12 and the fourth edge ultrasonic transducer 13 to work sequentially according to the set time interval; the working duty cycle of each edge ultrasonic transducer 5 is 25%.

[0056] In the first permeation-enhancing mode, the central ultrasonic transducer 4 works continuously, while the four peripheral ultrasonic transducers 5 work alternately to generate microbubbles with a mild permeation-enhancing effect.

[0057] At this point, the energy transferred by the multi-beam vector orthogonal ultrasonic permeation system to the target medium is:

[0058]

[0059] When the second permeation-enhancing mode is selected, the control unit controls the central ultrasonic transducer 4 to have a duty cycle of 0, and sequentially controls the first group of edge ultrasonic transducers and the second group of edge ultrasonic transducers to operate according to a set time interval. The duty cycle of each group of edge ultrasonic transducers is 50%. The first group of edge ultrasonic transducers includes a first edge ultrasonic transducer 10 and a third edge ultrasonic transducer 12. The second group of edge ultrasonic transducers includes a second edge ultrasonic transducer 11 and a fourth edge ultrasonic transducer 13.

[0060] In the second permeation-enhancing mode, the central ultrasonic transducer 4 works continuously, while the peripheral ultrasonic transducers 5 work in groups of two adjacent units, with the two groups working alternately to generate microbubbles with a moderate permeation-enhancing effect.

[0061] At this point, the energy transferred by the multi-beam vector orthogonal ultrasonic permeation system to the target medium is:

[0062]

[0063] When the third permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer 4 and each peripheral ultrasonic transducer 5 to be 0.

[0064] In the third permeation-enhancing mode, the central ultrasonic transducer 4 and the four peripheral ultrasonic transducers 5 work simultaneously and continuously to generate microbubbles with a strong permeation-enhancing effect.

[0065] At this point, the energy transferred by the multi-beam vector orthogonal ultrasonic permeation system to the target medium is:

[0066]

[0067] Where E is the energy transferred from the multi-beam vector orthogonal ultrasonic permeation system to the target medium, and P L0 P represents the acoustic pressure energy amplitude of the central ultrasonic transducer. H0 The amplitude of the acoustic pressure energy of each edge ultrasonic transducer.

[0068] In addition, the multi-beam vector orthogonal ultrasonic permeation system also includes a power supply device 9. The power supply device 9 is connected to the central processing unit 6.

[0069] This invention uses a microprocessor to calculate the emission voltage and emission time of ultrasound, and controls ultrasound transducers with different positions to output high and low frequency ultrasound with orthogonal sound beams, low energy and short working time. By superimposing the ultrasound cavitation effect through high frequency ultrasound (second ultrasound) and low frequency ultrasound (first ultrasound), the transdermal penetration of skin care active ingredients is improved. Moreover, the dual-frequency ultrasound will produce better ultrasound cavitation effect and shorter ultrasound action time at multiple target points.

[0070] To better understand the solution of the present invention, the following is combined with... Figure 4 This paper introduces the working process of a multi-beam vector orthogonal ultrasonic permeation enhancement system.

[0071] Step 1: Power on, instrument self-test, central processor 6 performs status detection on central ultrasonic control module 7 and edge ultrasonic control module 8 and completes initialization.

[0072] Step 2: Select the penetration enhancement mode and place the treatment head 2 firmly against the area to be treated.

[0073] Step 3: When the first permeation enhancement mode is selected, the central processor 6 controls the operation of the central ultrasound control module 7 and the edge ultrasound control module 8 respectively. The central ultrasound control module 7 controls the central ultrasound transducer 4 to work continuously, while the edge ultrasound control module 8 controls the four edge ultrasound high-frequency transducers 5 to work alternately in sequence at equal time intervals, thereby generating initial state ultrasound microbubbles in the liquid required for treatment.

[0074] Step 4: When the second permeation-enhancing mode is selected, the central processing unit 6 controls the operation of the central ultrasound control module 7 and the edge ultrasound control module 8 respectively. The central ultrasound control module 7 controls the central ultrasound transducer 4 to work continuously. The first edge ultrasound transducer 10 and the third edge ultrasound transducer 12 form one group, and the second edge ultrasound transducer 11 and the fourth edge ultrasound transducer 13 form another group. The edge ultrasound control module 8 controls the two edge ultrasound transducers 5 in each group to work simultaneously. The two groups work alternately at equal time intervals, so that the microbubbles are superimposed in the initial state.

[0075] Step 5: When the third permeation-enhancing mode is selected, the central processor 6 controls the operation of the central ultrasound control module 7 and the edge ultrasound control module 8 respectively. The central ultrasound control module 7 controls the central ultrasound transducer 4 to work continuously, and the edge ultrasound control module 8 controls the four edge ultrasound high-frequency transducers 5 to work continuously at the same time, so that the microbubbles generated under the action of low-frequency ultrasound enter the complex state under the action of high-frequency ultrasound from all directions.

[0076] Among them, the high-frequency operating sound intensity P H for:

[0077] Low-frequency operating sound intensity P L for:

[0078] Among them, P H0 P represents the acoustic pressure energy amplitude of a single edge ultrasonic transducer. L0 f represents the acoustic pressure energy amplitude of a single central ultrasonic transducer. H f is the frequency of the second ultrasound wave. L The frequency of the first ultrasound wave. For phase.

[0079] Step 6: If the treatment is complete, shut down the system and equipment; if not, repeat steps 2 through 5.

[0080] This invention calculates the emitted energy of ultrasound and controls the working time and amplitude of ultrasound transducers arranged in different positions to achieve adaptive and continuously adjustable ultrasound energy. It also achieves the superposition of ultrasound cavitation effects, thereby solving the problem of continuous heat generation in traditional ultrasound beauty ingredient penetration enhancement devices under continuous and strong cavitation penetration enhancement conditions. At the same time, based on single low-frequency or high-frequency ultrasound cavitation penetration enhancement, it achieves the superposition of cavitation penetration enhancement effects, and the generated microbubble morphology has a stronger penetration enhancement ability at the moment of destruction.

[0081] The multi-beam vector orthogonal ultrasound permeation enhancement system provided by this invention is a semi-automatic device. Treatment can be completed simply by selecting the permeation enhancement mode and placing it close to the treatment site. It is simple to operate, safe and reliable, highly integrated, easy to carry, and meets home use requirements. Furthermore, it can improve the efficiency of the acoustic coupling medium in reaching the desired location on the skin with less time and less consumables.

[0082] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A multi-beam vector orthogonal ultrasonic permeation enhancement system, characterized in that, The multi-beam vector orthogonal ultrasound permeation system includes: a treatment head, a control unit, an ultrasound transducer base, a central ultrasound transducer, and multiple peripheral ultrasound transducers. Multiple peripheral ultrasound transducers are distributed at the edge of the ultrasound transducer base; the central ultrasound transducer is located at the center of the multiple peripheral ultrasound transducers, and both the central ultrasound transducer and each peripheral ultrasound transducer are fixed to the treatment head. The central ultrasonic transducer is used to emit a first ultrasonic wave toward the target medium; each edge ultrasonic transducer is used to emit a second ultrasonic wave toward the target medium; the direction of the first ultrasonic wave is orthogonal to the direction of the second ultrasonic wave, and the frequency of the first ultrasonic wave is less than the frequency of the second ultrasonic wave. The control unit is connected to the central ultrasonic transducer and each edge ultrasonic transducer respectively. The control unit is used to control the duty cycle and working sequence of the central ultrasonic transducer and each edge ultrasonic transducer according to the permeation mode selected by the user. The number of edge ultrasonic transducers is four, namely: a first edge ultrasonic transducer, a second edge ultrasonic transducer, a third edge ultrasonic transducer, and a fourth edge ultrasonic transducer; the four edge ultrasonic transducers are arranged counterclockwise along the edge of the ultrasonic transducer base as the first edge ultrasonic transducer, the second edge ultrasonic transducer, the fourth edge ultrasonic transducer, and the third edge ultrasonic transducer. The infiltration-promoting modes include a first infiltration-promoting mode, a second infiltration-promoting mode, and a third infiltration-promoting mode; When the first permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer to be 0, and sequentially controls the first edge ultrasonic transducer, the second edge ultrasonic transducer, the third edge ultrasonic transducer, and the fourth edge ultrasonic transducer to work according to a set time interval; the duty cycle of each edge ultrasonic transducer is 25%; in the first permeation-enhancing mode, the central ultrasonic transducer works continuously, and the four edge ultrasonic transducers work alternately in turn to generate microbubbles with a mild permeation-enhancing effect; When the second permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer to 0, and sequentially controls the first group of edge ultrasonic transducers and the second group of edge ultrasonic transducers to work according to a set time interval; the duty cycle of each group of edge ultrasonic transducers is 50%; the first group of edge ultrasonic transducers includes a first edge ultrasonic transducer and a third edge ultrasonic transducer; the second group of edge ultrasonic transducers includes a second edge ultrasonic transducer and a fourth edge ultrasonic transducer; in the second permeation-enhancing mode, the central ultrasonic transducer works continuously, and the edge ultrasonic transducers work in groups of two adjacent units, with the two groups working alternately to generate microbubbles with a moderate permeation-enhancing effect; When the third permeation-enhancing mode is selected, the control component controls the duty cycle of the central ultrasonic transducer and each edge ultrasonic transducer to be 0. In the third permeation-enhancing mode, the central ultrasonic transducer and the four edge ultrasonic transducers work continuously at the same time to generate microbubbles with a strong permeation-enhancing effect.

2. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, The treatment head is filled with an acoustic coupling medium.

3. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, The direction of the first ultrasound wave is parallel to the treatment head; the direction of the second ultrasound wave is perpendicular to the extension of the tangent of the treatment head.

4. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, The frequency range of the first ultrasonic wave is 20kHz to 40kHz; the frequency range of the second ultrasonic wave is 1MHz to 3MHz.

5. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, The ultrasonic energy range of the first ultrasound wave is 0.1–0.3 mW / cm². 2 The second ultrasonic wave has an ultrasonic energy range of 0.2–0.5 mW / cm². 2 .

6. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, The control component includes: The central processing unit is used to generate central control signals and edge control signals according to the permeation mode selected by the user; A central ultrasound control module is connected to the central processor and the central ultrasound transducer respectively, and is used to control the duty cycle of the central ultrasound transducer according to the central control signal. The edge ultrasound control module is connected to the central processing unit and each edge ultrasound transducer, and is used to control the duty cycle and working sequence of each edge ultrasound transducer according to the edge control signal.

7. The multi-beam vector orthogonal ultrasonic permeation system according to claim 1, characterized in that, When the first permeation-enhancing mode is selected, the energy transferred to the target medium by the multi-beam vector orthogonal ultrasonic permeation-enhancing system is: When the second permeation-enhancing mode is selected, the energy transferred to the target medium by the multi-beam vector orthogonal ultrasonic permeation-enhancing system is: When selecting the third infiltration enhancement mode, the energy transferred to the target medium by the multi-beam vector orthogonal ultrasonic infiltration enhancement system is: Where E is the energy transferred from the multi-beam vector orthogonal ultrasonic permeation system to the target medium, and P L0 P represents the acoustic pressure energy amplitude of the central ultrasonic transducer. H0 The amplitude of the acoustic pressure energy of each edge ultrasonic transducer.

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