A device and method for eliminating artifacts of a helicobacter pylori detector

Abstract

The application discloses a kind of H. pylori detector artifact elimination device and method, the device includes detection unit, measurement unit, control system and sample sending unit;Control system includes receiving unit, processing unit and reaction unit;When H. pylori detector artifact elimination device detects that there is no gas collection card in the card slot, the air in the detection bin is measured by the measurement unit, the measurement result is processed by the processing unit and the artifact state is determined, the reaction unit makes corresponding reaction operation according to the artifact state and eliminates the residual high-speed ions in the air, and the prompt unit makes corresponding prompt according to the corresponding reaction operation of the reaction unit;The above-mentioned device can eliminate the residual high-speed ions in the detection bin, thereby eliminating the artifact state of H. pylori detector, avoiding the influence of artifact phenomenon on the detection result of gas collection card, improving the accuracy of instrument detection, and avoiding misjudgment of sample positive and negative.

Description

Technical Field

[0001] This invention relates to the field of medical testing device technology, specifically to a device and method for eliminating artifacts in a Helicobacter pylori detector. Background Technology

[0002] Helicobacter pylori is a Gram-negative bacterium mainly distributed in the gastric mucosa. It is strongly associated with the occurrence of gastric and duodenal ulcers and is listed as a Group 1 carcinogen. The metabolic activity of Helicobacter pylori (Hp) can produce highly active urease. Since urease is not present in mammalian cells, the presence of urease in the human stomach can serve as evidence of Helicobacter pylori (Hp) infection. 14 The C-urea breath test is a commonly used clinical method for detecting Helicobacter pylori. Patients take oral... 14 After C-urea is administered, if Helicobacter pylori is present in the stomach, the urease produced by it can rapidly decompose urea into carbon dioxide and ammonia. The carbon dioxide enters the lungs via the bloodstream and is expelled from the body; the patient's exhaled... 14 CO2 is collected and measured on a Helicobacter pylori detector to diagnose whether there is Helicobacter pylori infection in the stomach. This is a safe, cost-effective, and non-invasive testing method. 14 The C-urea breath test for Helicobacter pylori involves testing a gas collection card containing a labeled sample, providing a basis for medical personnel to diagnose stomach diseases.

[0003] During testing, when high-speed particles are injected into the Geiger-Müller tube from the gas collection card, the energy of the particles ionizes and conducts electricity within the tube, creating a rapid gas discharge between the wire electrode and the tube wall. This generates a pulse current signal, which the software counts to determine the positive or negative result of the gas collection card. However, after the gas collection card is removed, some high-speed particles remain in the measuring chamber, resulting in residual radiation. This residual radiation also generates a pulse current signal, creating a detection artifact. This artifact can cause false positives for negative samples, leading to misjudgments of the sample's positive or negative result and affecting the accuracy of the test. Summary of the Invention

[0004] To avoid misinterpretation of detection results due to artifacts caused by residual radiation, the present invention aims to provide an artifact elimination device for a Helicobacter pylori detector. The detector is equipped with a detection chamber with a gas collection slot. The device includes: a detection unit, a measurement unit, a control system, and a sample delivery unit; the control system includes a receiving unit, a processing unit, and a reaction unit; wherein:

[0005] The detection unit is used to detect whether there is a gas collection card on the gas collection card position of the detection chamber, and to send the detection result to the receiving unit;

[0006] The measurement unit includes a first measurement unit and a second measurement unit. The first measurement unit is used to measure the intensity of radiation generated by radioactive ions in the air inside the detection chamber and send the measurement data to the receiving unit. The second measurement unit is used to detect Helicobacter pylori on the gas collection card.

[0007] The receiving unit is used to receive the detection results sent by the detection unit and the measurement data transmitted by the first measurement unit;

[0008] The processing unit is used to call the detection unit or the measurement unit according to the detection result. The processing unit is also used to analyze the measurement data and make an artifact state according to the numerical range of the measurement data. At the same time, based on the artifact state judgment result, it issues an artifact state elimination command to the reaction unit.

[0009] The reaction unit is used to perform corresponding artifact removal reaction operations according to the artifact state removal command issued by the processing unit.

[0010] The sample delivery unit is used to deliver the gas collection card into the testing chamber.

[0011] Furthermore, it also includes a prompting unit, which is used to display the reaction status of the reaction unit and is electrically connected to the reaction unit.

[0012] Furthermore, it also includes a ventilation unit, which is used to replace the air in the detection chamber, and the ventilation unit is electrically connected to the reaction unit.

[0013] Furthermore, the detection unit includes a reflective sensor, which is disposed in a slot within the detection chamber.

[0014] Furthermore, the measuring unit includes a Geiger-Müller counter tube, a counter tube probe, and an automatic calibrator connected in sequence; the Geiger-Müller counter tube is disposed in the cavity of the detection chamber, and the automatic calibrator is connected to the receiving unit.

[0015] This invention also provides a method for eliminating artifacts in a Helicobacter pylori detector, which utilizes the aforementioned artifact elimination device for Helicobacter pylori detectors. The method includes the following steps:

[0016] S1. The Helicobacter pylori detector performs a self-test upon power-on, and the detection unit, measurement unit, control system, and sample delivery unit are all in normal working condition.

[0017] S2. The detection unit detects whether there is a gas collecting card in the gas collecting card position and transmits the detection result to the control system. The receiving unit of the control system makes a judgment based on the detection result received from the detection unit. If there is no gas collecting card, proceed to S3; if there is a gas collecting card, proceed to S5.

[0018] S3. The processing unit of the control system calls the first measurement unit of the measurement unit to measure the nuclear pulse value in the detection chamber. The measurement unit transmits the nuclear pulse value to the processing unit for artifact state determination. The artifact state is divided into strong artifact state, medium artifact state, weak artifact state and no artifact state. The processing unit of the control system transmits the artifact state determination result signal to the response unit of the control system.

[0019] S4. The control system's reaction unit performs the corresponding artifact elimination reaction operation based on the received artifact status judgment result signal and then returns to S2.

[0020] S5. The control system's reaction unit calls the second measurement unit of the measurement unit to perform Helicobacter pylori positive and negative tests on the gas collection card at the gas collection card position.

[0021] Furthermore, the artifact elimination reaction operation in step S4 specifically includes:

[0022] Strong artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 4 minutes to complete the cooling process;

[0023] Artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 2 minutes to complete the cooling process;

[0024] Weak artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 0.5 minutes to complete the cooling process;

[0025] When there are no artifacts or after the cooling is complete, the control unit sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device on it to open the detection chamber and then put the gas collection card to be tested into the gas collection card position.

[0026] Furthermore, the artifact elimination reaction operation in S4 specifically includes:

[0027] Strong artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 1 to the ventilation unit, the ventilation unit starts, ventilation lasts for 2 minutes, and ventilation is completed.

[0028] Artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 2 to the ventilation unit, the ventilation unit starts, ventilation lasts for 1 minute, and ventilation is completed.

[0029] Weak artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 3 to the ventilation unit, the ventilation unit starts, ventilation lasts for 0.25 minutes, and ventilation is completed;

[0030] When there are no artifacts or after the air exchange is completed, the reaction unit of the control system sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device set on it to open the detection chamber and then put the gas collection card to be tested into the gas collection card position.

[0031] Furthermore, it also includes step S6, which is performed synchronously with step S4, and the control system's reaction unit calls the prompting unit, which provides a corresponding status prompt for the artifact elimination operation response made by the reaction unit.

[0032] Furthermore, the notification unit is set as an indicator light or a countdown display.

[0033] The present invention has the following beneficial effects:

[0034] The artifact elimination device for the Helicobacter pylori detector of the present invention includes a detection unit, a measurement unit, a control system, and a sample delivery unit. The control system includes a receiving unit, a processing unit, and a reaction unit. When the device detects no gas collection card in the card slot through the detection unit, the measurement unit measures the radiation intensity of the air in the detection chamber. The measurement result is processed by the processing unit and the artifact status is determined. The reaction unit performs different reaction operations according to the artifact status to eliminate residual high-speed ions in the air. The prompting unit makes corresponding prompts according to the different reaction operations of the reaction unit. Through the above device, the residual high-speed ions in the detection chamber are eliminated, the artifact status of the Helicobacter pylori detector is eliminated, the influence of artifact phenomenon on the detection results of the gas collection card is avoided, the accuracy of instrument detection is improved, and misjudgment of positive and negative samples is avoided. Attached Figure Description

[0035] Figure 1 This is a schematic block diagram of the structure of the present invention.

[0036] Figure 2 This is a flowchart of the artifact elimination method of the present invention. Detailed Implementation

[0037] To more clearly and completely describe the technical solution of the present invention, the present invention will be further described in detail below through specific embodiments. It should be understood that the specific embodiments described herein are only for explaining the present invention and are not intended to limit the present invention. Various changes can be made within the scope of the claims of the present invention.

[0038] like Figure 1 As shown, the Helicobacter pylori detection instrument artifact elimination device provided by the present invention includes a detection unit, a measurement unit, a control system, and a sample delivery unit; the control system includes a receiving unit, a processing unit, and a reaction unit;

[0039] The detection unit is used to detect whether there is a gas collection card on the gas collection slot of the detection chamber and send the detection result to the receiving unit. The detection unit includes a reflective sensor installed in the slot of the detection chamber. The reflective sensor detects whether there is a gas collection card on the gas collection slot of the detection chamber and sends the detection result to the receiving unit.

[0040] The measurement unit includes a first measurement unit and a second measurement unit. The first measurement unit is used to measure the intensity of radiation generated by radioactive ions in the air inside the detection chamber and send the measurement data to the receiving unit. The second measurement unit is used to detect Helicobacter pylori on the gas collection card. The measurement unit includes a Geiger-Müller counter tube, a counter tube probe, and an automatic calibrator connected in sequence. The Geiger-Müller counter tube is placed inside the cavity of the detection chamber. The Geiger-Müller counter tube measures the intensity of radiation generated by radioactive ions in the air inside the detection chamber and sends the measurement results to the receiving unit through the automatic calibrator.

[0041] The receiving unit of the control system receives the detection results sent by the detection unit and the detection data transmitted by the first measurement unit;

[0042] The control system's processing unit calls either the first or second measurement unit based on the detection results. When a gas collection card is present in the gas collection slot within the detection chamber, the processing unit calls the second measurement unit to perform a Helicobacter pylori positive / negative test on the gas collection card. When no gas collection card is present in the gas collection slot within the detection chamber, the processing unit calls the first measurement unit to measure the radiation intensity of the air within the detection chamber. The first measurement unit transmits the radiation intensity measurement data C of the air within the detection chamber to the receiving unit of the control system. The control system's processing unit analyzes the detection data and processes it according to the data's numerical values. The system determines the artifact state: C>300 indicates a strong artifact state, 100≤C≤300 indicates a medium artifact state, 50≤C<100 indicates a weak artifact state, and C<50 indicates no artifact state. The processing unit of the control system issues different artifact elimination commands to the reaction unit according to the different artifact states. The reaction unit of the control system performs different artifact elimination reaction operations according to the artifact elimination commands given by the processing unit. The sample delivery unit includes an opening and closing device, which is controlled by the reaction unit. When the opening and closing device is opened, the gas collection card is sent into the detection chamber through the sample delivery unit.

[0043] like Figure 2 As shown, a method for eliminating artifacts in a Helicobacter pylori detector is described, which utilizes the aforementioned artifact elimination device for the Helicobacter pylori detector. The artifact elimination method includes the following steps:

[0044] S1. The Helicobacter pylori detector performs a self-test upon power-on, and the detection unit, measurement unit, control system, and sample delivery unit are all in normal working condition.

[0045] S2. The detection unit detects whether there is a gas collecting card in the gas collecting card position and transmits the detection result to the control system. The receiving unit of the control system makes a judgment based on the detection result received from the detection unit. If there is no gas collecting card, proceed to S3; if there is a gas collecting card, proceed to S5.

[0046] S3. The processing unit of the control system calls the first measurement unit of the measurement unit to measure the nuclear pulse value in the detection chamber. The measurement unit transmits the nuclear pulse value to the processing unit for artifact state determination. The artifact state is divided into strong artifact state, medium artifact state, weak artifact state and no artifact state. The processing unit of the control system transmits the artifact state determination result signal to the response unit of the control system.

[0047] S4. The control system's reaction unit performs the corresponding artifact elimination reaction operation based on the received artifact status judgment result signal and then returns to S2.

[0048] S5. The control system's reaction unit calls the second measurement unit of the measurement unit to perform a positive or negative test for Helicobacter pylori on the gas collection card.

[0049] Simultaneously with step S4, step S6 is performed, whereby the control system's reaction unit calls the prompting unit, which provides a corresponding status prompt for the artifact elimination reaction made by the reaction unit.

[0050] In one embodiment, the artifact removal reaction operation performed by the reaction unit in step S4 is cooling. Depending on the artifact state, the reaction unit performs strong artifact removal, medium artifact removal, weak artifact removal, and no artifact removal operations, respectively.

[0051] Strong artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, the device stops detection, and cools for 4 minutes to complete the cooling process;

[0052] Artifact elimination reaction operation: The sample delivery unit controls the opening and closing device to close the detection chamber, the device stops detection, and cools for 2 minutes to complete the cooling process;

[0053] Weak artifact elimination reaction operation: The sample delivery unit controls the opening and closing device to close the detection chamber, the device stops detection, and cools for 0.5 minutes to complete the cooling process;

[0054] During the artifact-free elimination reaction operation, i.e., when there is no artifact and after cooling is complete, the reaction unit sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device to open the detection chamber and the gas collection card to be tested is placed in.

[0055] Simultaneously, step S6 is performed concurrently with step S4. The control system's reaction unit calls the prompting unit, which provides a corresponding status prompt for the artifact elimination reaction performed by the reaction unit. The prompting unit displays the reaction operation status of the reaction unit and is set as an indicator light. The corresponding states of the indicator light are: red during artifact elimination reaction operation; green when there are no artifacts or when cooling is complete; or the indicator light states can be set as follows: solid red during strong artifact elimination reaction operation; flashing red during medium artifact elimination reaction operation; flashing green during weak artifact elimination reaction operation; solid green when there is no artifact elimination reaction or when ventilation is complete.

[0056] At this point, the artifact elimination device of the Helicobacter pylori detector has eliminated the artifact state. Correspondingly, the opening and closing device of the sample delivery unit is opened, the detection chamber is opened, and the gas collection card to be tested can be placed into the detection chamber for Helicobacter pylori positive and negative detection.

[0057] In another embodiment, the artifact elimination device for the Helicobacter pylori detector further includes a ventilation unit. The ventilation unit includes a blower pipe fixed inside the detection chamber. The blower pipe has an air outlet on one side of the detection chamber, and a strip-shaped air outlet is formed on the side wall of the detection chamber opposite to the air outlet. The blower pipe is connected to an air pump, and the reaction unit controls the air pump. In step S4, the reaction unit controls the ventilation unit to perform an artifact elimination operation. The artifact elimination reaction operation specifically includes:

[0058] Strong artifact elimination reaction operation: The reaction unit sends a ventilation command 1 to the ventilation unit, the ventilation unit starts, ventilation lasts for 2 minutes, and ventilation is completed.

[0059] Artifact elimination reaction operation: The reaction unit sends a ventilation command 2 to the ventilation unit, the ventilation unit starts, ventilation lasts for 1 minute, and ventilation is completed;

[0060] Weak artifact elimination reaction operation: The reaction unit sends a ventilation command 3 to the ventilation unit, the ventilation unit starts, ventilation lasts for 0.25 minutes, and ventilation is completed;

[0061] During the artifact-free elimination reaction operation, i.e., when there is no artifact and after the gas exchange is completed, the reaction unit sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device to open the detection chamber and insert the gas collection card to be tested.

[0062] In this embodiment, in step S6, the prompting unit for displaying the reaction operation status of the reaction unit is set as a countdown display. During the strong artifact elimination reaction operation, the countdown display counts down for 2 minutes; during the medium artifact elimination reaction operation, the countdown display counts down for 1 minute; during the weak artifact elimination reaction operation, the countdown display counts down for 0.25 minutes; and during the no-artifact elimination reaction operation and after the ventilation is completed, the countdown display counts down for 0 minutes.

[0063] At this point, the artifact elimination device of the Helicobacter pylori detector has eliminated the artifact state, and the gas collection card to be tested can be placed into the detection chamber for positive and negative detection of Helicobacter pylori.

[0064] The above embodiments are merely preferred technical solutions of the present invention and should not be considered as limitations on the present invention. The scope of protection of the present invention should be limited to the technical solutions described in the claims, including equivalent substitutions of the technical features described in the claims. That is, equivalent substitutions and improvements within this scope are also within the scope of protection of the present invention.

Claims

1. A device for eliminating artifacts in a Helicobacter pylori detector, wherein the Helicobacter pylori detector is equipped with a detection chamber for collecting gas, characterized in that, include: The system comprises a detection unit, a measurement unit, a control system, and a sample delivery unit; the control system includes a receiving unit, a processing unit, and a reaction unit; wherein: The detection unit is used to detect whether there is a gas collection card on the gas collection card position of the detection chamber, and to send the detection result to the receiving unit; The measurement unit includes a first measurement unit and a second measurement unit. The first measurement unit is used to measure the intensity of radiation generated by radioactive ions in the air inside the detection chamber and send the measurement data to the receiving unit. The second measurement unit is used to detect Helicobacter pylori on the gas collection card. The receiving unit is used to receive the detection results sent by the detection unit and the measurement data transmitted by the first measurement unit; The processing unit is used to call the measurement unit according to the detection results. The processing unit is also used to analyze the measurement data and make an artifact state according to the numerical range of the measurement data. At the same time, based on the artifact state judgment result, it issues an artifact state elimination command to the reaction unit. The reaction unit is used to perform corresponding artifact elimination reaction operations according to the artifact state elimination command issued by the processing unit. Artifact elimination refers to cooling or air exchange operations based on the artifact state in the detection chamber. The sample delivery unit is used to deliver the gas collection card into the testing chamber.

2. The artifact elimination device for a Helicobacter pylori detector as described in claim 1, characterized in that, It also includes a prompting unit, which is used to display the reaction status of the reaction unit and is electrically connected to the reaction unit.

3. The artifact elimination device for a Helicobacter pylori detector as described in claim 1, characterized in that, It also includes a ventilation unit, which is used to replace the air in the detection chamber. The ventilation unit is electrically connected to the reaction unit.

4. The artifact elimination device for a Helicobacter pylori detector as described in claim 1, characterized in that, The detection unit includes a reflective sensor, which is installed in a slot within the detection chamber.

5. The artifact elimination device for a Helicobacter pylori detector as described in claim 1, characterized in that, The measuring unit includes a Geiger-Müller counter tube, a counter tube probe, and an automatic calibrator connected in sequence; the Geiger-Müller counter tube is set inside the cavity of the detection chamber, and the automatic calibrator is connected to the receiving unit.

6. A method for eliminating artifacts in a Helicobacter pylori detection instrument, characterized in that, The method for artifact elimination using the artifact elimination device of the Helicobacter pylori detector according to any one of claims 1-5 includes the following steps: S1. The Helicobacter pylori detector performs a self-test upon power-on, and the detection unit, measurement unit, control system, and sample delivery unit are all in normal working condition. S2. The detection unit detects whether there is a gas collecting card in the gas collecting card position and transmits the detection result to the control system. The receiving unit of the control system makes a judgment based on the detection result received from the detection unit. If there is no gas collecting card, proceed to S3; if there is a gas collecting card, proceed to S5. S3. The processing unit of the control system calls the first measurement unit of the measurement unit to measure the nuclear pulse value in the detection chamber. The measurement unit transmits the nuclear pulse value to the processing unit for artifact state determination. The artifact state is divided into strong artifact state, medium artifact state, weak artifact state and no artifact state. The processing unit of the control system transmits the artifact state determination result signal to the response unit of the control system. S4. The control system's reaction unit performs the corresponding artifact elimination reaction operation based on the received artifact status judgment result signal and then returns to S2. S5. The control system's reaction unit calls the second measurement unit of the measurement unit to perform Helicobacter pylori positive and negative tests on the gas collection card at the gas collection card position.

7. The method for eliminating artifacts in a Helicobacter pylori detector as described in claim 6, characterized in that, The artifact elimination reaction operation in step S4 specifically includes: Strong artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 4 minutes to complete the cooling process; Artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 2 minutes to complete the cooling process; Weak artifact elimination reaction operation: The sample delivery unit controls the opening and closing device on it to close the detection chamber, stop the detection, and cool for 0.5 minutes to complete the cooling process; When there are no artifacts or after the cooling is complete, the control unit sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device on it to open the detection chamber and then put the gas collection card to be tested into the gas collection card position.

8. The method for eliminating artifacts in a Helicobacter pylori detector as described in claim 6, characterized in that, The artifact elimination reaction operation in S4 specifically includes: Strong artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 1 to the ventilation unit, the ventilation unit starts, ventilation lasts for 2 minutes, and ventilation is completed. Artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 2 to the ventilation unit, the ventilation unit starts, ventilation lasts for 1 minute, and ventilation is completed. Weak artifact elimination reaction operation: The reaction unit of the control system sends a ventilation command 3 to the ventilation unit, the ventilation unit starts, ventilation lasts for 0.25 minutes, and ventilation is completed; When there are no artifacts or after the air exchange is completed, the reaction unit of the control system sends an opening command to the sample delivery unit. The sample delivery unit controls the opening and closing device set on it to open the detection chamber and then put the gas collection card to be tested into the gas collection card position.

9. A method for eliminating artifacts in a Helicobacter pylori detector as described in claim 7 or 8, characterized in that, It also includes step S6, which is performed synchronously with step S4, and the control system's reaction unit calls the prompting unit, which provides a corresponding status prompt for the artifact elimination reaction operation performed by the reaction unit.

10. The method for eliminating artifacts in a Helicobacter pylori detector as described in claim 9, characterized in that, The notification unit is set as an indicator light or a countdown display.

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