A Chinese medicine composition and its preparation method and application

Abstract

The present invention provides a Chinese medicine composition and a preparation method and application thereof. The Chinese medicine composition comprises, by weight, 6-10 parts of emblica, 8-16 parts of euphorbia pulex, 3-6 parts of platycodon grandiflorum, 8-12 parts of horse thorn, 8-10 parts of fennel, 8-12 parts of vernonia scabra, and 6-10 parts of ginseng root. The present invention shows that the combination of emblica, euphorbia pulex, platycodon grandiflorum, horse thorn and fennel has a certain analgesic effect. After adding vernonia pulex and ginseng root, the analgesic effect is greatly increased, and the composition can be used to relieve throat pain.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] Sore throat is a common clinical disease, which belongs to the categories of acute pharyngitis, simple laryngitis, acute tonsillitis, peritonsillar abscess and other diseases in modern medicine, and belongs to the categories of "throat paralysis", "milk moth" and "throat carbuncle" in traditional Chinese medicine. The typical symptoms of acute sore throat are sudden redness, swelling and pain in the throat, which is aggravated when swallowing and can even radiate to the ears. It can be accompanied by cold and heat headache, floating pulse or dry throat, thirst, constipation, yellow urine, red tongue with yellow fur, and strong pulse.

[0003] At present, Western medicine mainly uses antibiotics or antiviral treatments to treat sore throats. Long-term use may cause gastrointestinal discomfort and easily lead to drug resistance. It is also ineffective for sore throats caused by non-bacterial or viral causes. Traditional Chinese medicine generally treats sore throats based on individual differences. There are also some traditional Chinese medicine products on the market for sore throats, and the treatment effects vary from person to person. Summary of the invention

[0004] In order to solve the above problems of the prior art, the present invention provides a Chinese medicine composition and a preparation method and application thereof. The Chinese medicine composition has obvious analgesic effect and can be used to treat sore throat with significant therapeutic effect.

[0005] The present invention is achieved through the following technical solutions:

[0006] A traditional Chinese medicine composition comprises, by weight, 6-10 parts of emblica emblica, 8-16 parts of scutellaria baicalensis, 3-6 parts of platycodon grandiflorum, 8-12 parts of horsetail, 8-10 parts of scutellaria baicalensis, 8-12 parts of vernonia salsa, and 6-10 parts of ginseng root.

[0007] Preferably, the composition comprises, by weight: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodiellae, 5 parts of Platycodon grandiflorus, 10 parts of Echinops strychnifolia, 8 parts of Herba Lycopodiellae, 10-12 parts of Vernonia scabra, and 8-10 parts of Glossy Ganoderma.

[0008] Preferably, the composition, calculated by weight, includes: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodiellae, 5 parts of Platycodon grandiflorus, 10 parts of Echinops strychnifolia, 8 parts of Vernonia ovatae, 8 parts of Vernonia obovatae, and 6 parts of Ginseng Root.

[0009] Preferably, the composition, calculated by weight, includes: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodii, 5 parts of Platycodon grandiflorum, 10 parts of Echinops strychnifolia, 8 parts of Vernonia ovata, 10 parts of Vernonia willowii, and 8 parts of Ginseng Root.

[0010] Preferably, the composition, calculated by weight, includes: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodii, 5 parts of Platycodon grandiflorus, 10 parts of Echinops strychnifolia, 8 parts of Herba Lycopodii, 12 parts of Vernonia scabra, and 10 parts of Glossy Ganoderma.

[0011] Preferably, the composition, calculated by weight, includes: 10 parts of emblica emblica, 16 parts of scutellaria baicalensis, 6 parts of platycodon grandiflorum, 12 parts of horsetail, 10 parts of scutellaria baicalensis, 8 parts of vernonia salsa, and 6 parts of ginseng root.

[0012] Preferably, the dosage form is tablet, granule, capsule or liquid preparation.

[0013] The preparation method of the traditional Chinese medicine composition comprises: taking the traditional Chinese medicine materials of emblica emblica, scutellaria baicalensis, platycodon grandiflorum, scutellaria baicalensis, horsethorn, vernonia oleracea and ginseng root, soaking them in water, heating and refluxing for extraction, repeating the extraction for several times, combining the filtrate, filtering, concentrating, drying and crushing to obtain the traditional Chinese medicine composition.

[0014] The application of the traditional Chinese medicine composition in preparing medicine for treating sore throat.

[0015] The application of the traditional Chinese medicine composition in the preparation of analgesic drugs.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The Chinese medicine composition of the invention comprises emblica fruit, dandelion, platycodon grandiflorum, horsethorn, fennel, vernonia scabra, and ginseng root.

[0018] Emblica emblica is the dried mature fruit of Phyllanthus emblica L., a plant of the Euphorbiaceae family. It has the effects of promoting fluid production and relieving cough, promoting digestion and strengthening the stomach, as well as clearing away heat and cooling blood. It is suitable for treating symptoms such as sore throat and dry mouth, cough, abdominal distension, indigestion and blood stasis.

[0019] Elephantopus scaber L. is the dried whole herb of the Asteraceae plant Elephantopus scaber L. It has the effects of clearing away heat and purging fire, cooling blood and detoxifying, and is used for colds and fever, sore throats, lung heat and coughs, etc.

[0020] Platycodon is the dried root of Platycodon grandiflorum (Jacq.) A.DC. of the Campanulaceae family. It has the effects of clearing the lungs, relieving sore throat, removing phlegm, and discharging pus. It is used for cough with excessive phlegm, chest tightness, sore throat and hoarseness, and lung abscess with pus.

[0021] Herba Cibotii is the dried whole herb of Anaphalis bulleyana (JFJeffr.) Chang, a plant of the Asteraceae family. It is a traditional medicine of the Yi ethnic group and has the effects of dispelling wind and cold, relieving cough and reducing phlegm, harmonizing the stomach and relieving diarrhea. It is used for colds, coughs with phlegm, sore throat, abdominal distension and pain, diarrhea, and dysentery.

[0022] Horse thorn is the root or above-ground part of Indigofera pseudotinctoria Matsum., a plant of the genus Indigofera in the Leguminosae family. It is a traditional medicine of the Yi ethnic group. It has the effects of cooling and detoxifying, promoting blood circulation and removing blood stasis. It is used to treat wind-heat colds, pneumonia and high fever.

[0023] Vernonia saligna is the root of Vernonia saligna (Wall.) DC., a plant of the Asteraceae family. It is a traditional medicine of the Yi ethnic group and has the effects of strengthening the spleen and digestion, moistening the lungs and relieving cough.

[0024] The fleshy root of Crepis napifera is the root or whole herb of Crepis napifera (Franch.) Babc. of the Asteraceae family. It has the effects of moistening the lungs, relieving cough, and anti-inflammatory and invigorating vitality.

[0025] The research of the present invention shows that the combination of emblica, elegans, platycodon, horsethorn and scutellaria has a certain analgesic effect. After adding Vernonia scabra and Glehnia littoralis, the analgesic effect is greatly increased, and the product can be used to relieve throat pain. DETAILED DESCRIPTION

[0026] In order to further understand the present invention, the present invention is described below in conjunction with embodiments. These descriptions are only to further explain the features and advantages of the present invention and are not intended to limit the claims of the present invention.

[0027] The Chinese medicine composition of the present invention comprises, by weight, 6-10 parts of emblica fruit, 8-16 parts of scutellaria baicalensis, 3-6 parts of platycodon grandiflorum, 8-12 parts of horsetail, 8-10 parts of scutellaria baicalensis, 8-12 parts of vernonia salsa, and 6-10 parts of ginseng root.

[0028] The Chinese medicine composition of the present invention preferably comprises, by weight, 8 parts of emblica emblica, 13 parts of scutellaria baicalensis, 5 parts of platycodon grandiflorum, 10 parts of horsetail, 8 parts of scutellaria baicalensis, 10-12 parts of vernonia salsa, and 8-10 parts of ginseng root.

[0029] The invention can be prepared into conventional dosage forms such as tablets, granules, capsules, liquid preparations, etc. according to conventional preparation processes, and can be used for analgesia, such as relieving sore throat.

[0030] The preparation method of the Chinese medicine composition of the present invention comprises:

[0031] Take Chinese medicinal materials such as emblica emblica, dandelion, platycodon, fennel, horsethorn, vernonia, and ginseng root, weigh the medicinal materials according to the above proportions, mix them evenly, soak them in water, heat and reflux to extract, repeat the extraction several times, combine the filtrate, filter, concentrate, dry and crush to obtain a Chinese medicine composition.

[0032] Example 1 Preparation of Chinese medicine composition

[0033] A. Weigh the emblica oleracea, dandelion, platycodon grandiflorum, scutellaria baicalensis, horsetail, vernonia oleracea, and ginseng root according to the components in the experimental groups and the comparative groups in Table 1, and mix them evenly.

[0034] B. Add 10 times the weight of water to the mixed medicinal materials in step A, soak for 0.5 hours, perform heat reflux extraction for 1 hour, repeat the extraction twice, combine the extracts, concentrate under reduced pressure, dry, and crush to obtain an extract powder.

[0035] Table 1 Composition of each Chinese medicine ingredient in the experimental group and the control group

[0036] Phyllanthus emblica Echinops spp. Platycodon grandiflorum Horsethorn Afternoon Vanilla Vernonia Ginseng root Experimental Group 1 8 servings 13 servings 5 servings 10 servings 8 servings 8 servings 6 servings Experimental Group 2 8 servings 13 servings 5 servings 10 servings 8 servings 10 servings 8 servings Experimental Group 3 8 servings 13 servings 5 servings 10 servings 8 servings 12 servings 10 servings Experimental Group 4 10 servings 16 servings 6 servings 12 servings 10 servings 8 servings 6 servings Comparison group 1 4 servings 4 servings 2 servings 4 servings 6 servings 8 servings 6 servings Comparison group 2 12 servings 20 servings 8 servings 20 servings 12 servings 8 servings 6 servings Comparison group 3 8 servings 13 servings 5 servings 10 servings 8 servings 6 servings 4 servings Comparison group 4 8 servings 13 servings 5 servings 10 servings 8 servings 14 servings 12 servings Comparison group 5 8 servings 13 servings 5 servings 10 servings 8 servings none none Comparison group 6 8 servings 13 servings 5 servings 10 servings 8 servings none 6 servings Comparison group 7 8 servings 13 servings 5 servings 10 servings 8 servings 8 servings none Comparison group 8 none none none none none 8 servings 6 servings

[0037] Example 2 Evaluation of analgesic effect in mice

[0038] Mouse grouping: Five-week-old male mice, 18-22 g, were selected. Experimental groups: 13 groups in total: control group, experimental groups 1-4 (corresponding to experimental groups 1-4 in Table 1), and comparison groups 1-8 (corresponding to comparison groups 1-8 in Table 1).

[0039] Dosage scheme: Prepare the Chinese medicine composition according to the formula in Table 1 and set aside. Use the gavage method to gavage the medicine once a day according to the set dose for 1 week; the gavage volume is 1.0 g / (kg·BW), and the control group is gavaged with 0.25 mL of normal saline per head, once a day, for 1 week.

[0040] Establishment of glacial acetic acid-induced writhing model in mice: 6 hours after the last administration, each group of mice was given 0.02 mL / (10 g·BW) of 20% glacial acetic acid solution by intragastric administration. After waiting for 10 minutes after intragastric administration, the body posture changes and the number of writhing times of the mice within 20 minutes were observed and recorded, and the analgesic percentage was calculated. The results are shown in Table 2.

[0041] Analgesia percentage = (number of writhings in the control group mice - number of writhings in the drug group mice) / number of writhings in the control group mice × 100%.

[0042] Table 2 The writhing times and analgesia percentage of mice in each group

[0043] Group Number of twists (times) Analgesia percentage (%) Control group 98.45±5.24 —— Experimental Group 1 52.51±4.32 46.66％ Experimental Group 2 40.18±3.19 59.19％ Experimental Group 3 34.61±3.39 64.85％ Experimental Group 4 55.85±5.30 43.27％ Comparison group 1 70.22±7.92 28.67％ Comparison group 2 67.16±8.38 31.78％ Comparison group 3 73.44±5.81 25.40％ Comparison group 4 69.01±9.85 29.90％ Comparison group 5 83.25±6.05 16.46％ Comparison group 6 80.47±10.55 18.26％ Comparison group 7 82.47±9.88 16.23％ Comparison group 8 94.67±11.75 3.84％

[0044] As shown in Table 2, the analgesic percentage of experimental group 1-3 increases with the increase of Vernonia oleracea and Radix Glehniae dosage. The analgesic percentage of comparison group 1-4 is significantly lower than that of experimental group 1-4, indicating that the drug flavor ratio is inappropriate. The analgesic percentage of comparison group 5 without Vernonia oleracea and Radix Glehniae is significantly lower than that of experimental group 1-4, and the comparison group 8 only with Vernonia oleracea and Radix Glehniae has no obvious analgesic effect, Vernonia oleracea and Radix Glehniae itself do not have obvious analgesic effect, but when used in conjunction with Fructus Phyllanthus, Herba Lycopodii, Radix Platycodonis, Herba Lycopodii, Echinops, the analgesic effect of Fructus Phyllanthus, Herba Lycopodii, Radix Platycodonis, Herba Lycopodii, Echinops can be significantly improved, indicating that Vernonia oleracea and Radix Glehniae have certain synergistic effect between Fructus Phyllanthus, Herba Lycopodii, Radix Platycodonis, Herba Lycopodii and Echinops. Although the analgesic percentage of the comparison group 6 is improved compared with that of the comparison group 5, it is not significant, indicating that Vernonia oleracea and Ginseng radix need to be used together to achieve a better synergistic effect. These indicate that the composition and ratio of the formula of the present invention have an important influence on the analgesic effect of the composition, and there is a synergistic effect between the components. The above experiments prove that the Chinese medicine composition of the present invention has a good analgesic effect, and can therefore be used for the treatment of various pains, such as sore throat.

[0045] Example 3 Clinical Application

[0046] 60 people with sore throat symptoms were recruited and randomly divided into 4 groups, 15 people in each group, where the control group took a placebo, the experimental group took the extract prepared by the formula of experimental group 3 in Example 1, the comparison group 1 took the extract prepared by the formula of comparison group 5 in Example 1, and the comparison group 2 took the extract prepared by the formula of comparison group 8 in Example 1. Each group dissolved the sample in warm water and swallowed it, 1 g each time, once a day, and 3 days as a course of treatment; the results are shown in Table 3.

[0047] Table 3 Statistics of treatment effects in each group

[0048] Group Number of people cured Cure rate% Control group 2 13.3％ Experimental Group 13 86.7％ Comparison group 1 7 46.7％ Comparison group 2 3 20.0％

[0049] The above experiments prove that the Chinese medicine composition of the present invention has a significant therapeutic effect on sore throat compared with the control group and the comparison group 1-2, and has a very high cure rate. That is, although the combination of Phyllanthus emblica, Herba Lycopodii, Radix Platycodonis, Herba Echinopteris, and Herba Lycopodii has a certain analgesic effect, the effect is relatively weak. After adding Vernonia salsa and Herba Lycopodii, the analgesic effect is greatly increased, and the therapeutic effect is significantly enhanced.

[0050] The above contents are only for explaining the technical idea of ​​the present invention and cannot be used to limit the protection scope of the present invention. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present invention shall fall within the protection scope of the claims of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: Calculated by weight, the composition comprises the following medicinal materials: 8-10 parts of emblica buds, 13-16 parts of scutellaria baicalensis, 5-6 parts of platycodon grandiflorum, 10-12 parts of horsetail, 8-10 parts of scutellaria baicalensis, 8-12 parts of vernonia ovata, and 6-10 parts of ginseng root.

2. The Chinese medicine composition according to claim 1, characterized in that: The composition is composed of the following medicinal materials in terms of weight: 8 parts of emblica emblica, 13 parts of scutellaria baicalensis, 5 parts of platycodon grandiflorum, 10 parts of horsetail, 8 parts of scutellaria baicalensis, 10-12 parts of vernonia salsa, and 8-10 parts of ginseng root.

3. The Chinese medicine composition according to claim 1, characterized in that The composition is composed of the following medicinal materials in terms of weight: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodiellae, 5 parts of Platycodon grandiflorum, 10 parts of Echinops paniculata, 8 parts of Herba Lycopodiellae, 8 parts of Vernonia ovatae, and 6 parts of Ginseng Root.

4. The Chinese medicine composition according to claim 1, characterized in that: The composition is composed of the following medicinal materials in terms of weight: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodiellae, 5 parts of Platycodon grandiflorum, 10 parts of Echinops strychnifolia, 8 parts of Vernonia ovata, 10 parts of Vernonia willowleaf, and 8 parts of Ginseng Root.

5. The Chinese medicine composition according to claim 1, characterized in that: The composition is composed of the following medicinal materials in terms of weight: 8 parts of Phyllanthus emblica, 13 parts of Herba Lycopodiellae, 5 parts of Platycodon grandiflorum, 10 parts of Echinops paniculata, 8 parts of Herba Lycopodiellae, 12 parts of Vernonia salsa, and 10 parts of Ganoderma lucidum.

6. The Chinese medicine composition according to claim 1, characterized in that: According to the weight percentage, the following medicinal materials are used: Composition: 10 parts of emblica emblica, 16 parts of scutellaria baicalensis, 6 parts of platycodon grandiflorum, 12 parts of horsethorn, 10 parts of scutellaria baicalensis, 8 parts of vernonia salsa, and 6 parts of ginseng root.

7. The Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The dosage form is tablet, granule, capsule or liquid preparation.

8. The method for preparing the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: include: Take Chinese medicinal materials such as emblica emblica, dandelion, platycodon, fennel, horsethorn, vernonia and ginseng root, soak them in water, heat and reflux to extract, repeat the extraction several times, combine the filtrate, filter, concentrate, dry and crush to obtain a Chinese medicine composition.

9. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicine for treating sore throat.

10. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of analgesics.