A sebum-biomimetic composition, its preparation method and use

Abstract

The present application belongs to the technical field of daily chemical products, and discloses a sebum biomimetic composition, a preparation method and application thereof.The sebum biomimetic composition comprises components: squalane, PEG-80 sorbitan laurate, glycerol, a sugar isomer and glyceryl oleate.The sebum biomimetic composition obtained by reasonable collocation of squalane, PEG-80 sorbitan laurate, glycerol, a sugar isomer and glyceryl oleate has synergistic effects among the components, has the effects of moisturizing and enhancing skin barrier function, is non-irritating and safe and mild to infant skin, and can be applied to washing and caring products, especially infant washing and caring products, so as to reduce the irritation of infant washing and caring products, form a biomimetic sebum layer on the skin surface, and thus enhance the skin barrier function, fundamentally solving the problem of great irritation of infant washing and caring products.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of daily chemical products, and particularly relates to a sebum biomimetic composition, a preparation method and application thereof. BACKGROUND

[0002] With the increasing distinction between baby and adult washing and caring products, baby washing and caring products are more and more abundant, such as baby shampoo and body wash, baby bubble shampoo, boy and girl shampoo, bubble body wash, etc. However, the skin of babies is more delicate, and is more sensitive to product irritation. At present, the main components of most baby washing and caring products are surfactants and natural plant extracts. Too much surfactant has great irritation and can easily cause the skin of babies to become less resistant, thereby damaging the sebum film of babies and damaging the skin barrier.

[0003] Therefore, it is necessary to develop a washing and caring product which is mild and non-irritating and can enhance the skin barrier of babies. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a sebum biomimetic composition, a preparation method and application thereof. The sebum biomimetic composition can reduce the irritation of washing and caring products, strengthen the lipid layer of the skin, and enhance the skin barrier. It is suitable for use in baby washing and caring products.

[0005] The present application provides a sebum biomimetic composition in the first aspect, which comprises the following components: squalane, PEG-80 sorbitan laurate, glycerol, sugar isomer and glyceryl oleate.

[0006] According to some embodiments of the present application, the sebum biomimetic composition comprises the following components: squalane 5-20 parts, PEG-80 sorbitan laurate 20-40 parts, glycerol 20-40 parts, sugar isomer 20-40 parts and glyceryl oleate 5-20 parts by mass fraction.

[0007] According to some embodiments of the present application, the sebum biomimetic composition comprises the following components: squalane 10-20 parts, PEG-80 sorbitan laurate 30-40 parts, glycerol 30-40 parts, sugar isomer 25-40 parts and glyceryl oleate 9-20 parts by mass fraction.

[0008] The present application provides a preparation method of the sebum biomimetic composition in the second aspect, which comprises the following steps:

[0009] The squalane, PEG-80 sorbitan laurate, glycerol, sugar isomer and glyceryl oleate are mixed to obtain the sebum biomimetic composition.

[0010] The third aspect of the present application provides a washing and caring product comprising the sebum biomimetic composition of the present application.

[0011] According to some embodiments of the present application, the sebum biomimetic composition is added in an amount of 0.01-50wt%.

[0012] According to some embodiments of the present application, the sebum biomimetic composition is added in an amount of 5-50wt%.

[0013] According to some embodiments of the present application, the washing and caring product is a baby washing and caring product.

[0014] According to some embodiments of the present application, the baby washing and caring product comprises any one of baby shampoo, bubble bath, baby shampoo and bubble bath.

[0015] The fourth aspect of the present application provides a bubble bath comprising the sebum biomimetic composition of the present application and cosmetically acceptable adjuvants.

[0016] According to some embodiments of the present application, the adjuvants comprise at least one of surfactants, pH regulators, preservatives, chelating agents.

[0017] Compared with the prior art, the present application has the following advantages:

[0018] The sebum biomimetic composition of the present application, which is obtained by reasonable collocation of squalane, PEG-80 sorbitan laurate, glycerol, sugar isomer and glyceryl oleate, has synergistic effect among the components, has the effects of moisturizing and enhancing skin barrier function, is non-irritating and safe and mild to baby skin; when applied to washing and caring products, especially baby washing and caring products, it can reduce the irritation of baby washing and caring products, forms a biomimetic sebum layer on the skin surface, thereby enhancing the skin barrier function, and fundamentally solves the problem of high irritation of baby washing and caring products. DETAILED DESCRIPTION

[0019] The content of the present application is further described in detail through specific examples. The raw materials, reagents or devices used in the examples, unless otherwise specified, can be obtained from conventional commercial channels or can be obtained by prior art methods. Unless otherwise specified, the test or test method is a conventional method in the art.

[0020] In the following examples, the sugar isomer is selected from the following products of DSM Nutritional Products Ltd.:

[0021] The components of the commercially available bubble bath include sodium laureth sulfate, cocamidopropyl betaine, glycerin, hydroxypropyl methylcellulose, polyquaternium-7, persea gratissima (avocado) fruit oil, simmondsia chinensis (jojoba) seed oil, etc.

[0022] Example 1

[0023] A sebum biomimetic composition includes the following components in mass fractions:

[0024]

[0025] The preparation method of the sebum biomimetic composition of the present embodiment is to uniformly mix squalane, PEG-80 sorbitan laurate, glycerin, sugar isomer, and glyceryl oleate in proportion to obtain the sebum biomimetic composition.

[0026] Example 2

[0027] A sebum biomimetic composition includes the following components in mass fractions:

[0028]

[0029] Example 3

[0030] A sebum biomimetic composition includes the following components in mass fractions:

[0031]

[0032] Example 4

[0033] A sebum biomimetic composition includes the following components in mass fractions:

[0034]

[0035]

[0036] Example 5

[0037] A sebum biomimetic composition includes the following components in mass fractions:

[0038] Example 6

[0039] A sebum biomimetic composition includes the following components in mass fractions:

[0040] Example 7

[0041] A sebum biomimetic composition includes the following components in mass fractions:

[0042] Example 8

[0043] A sebum mimicking composition comprising the following components in mass parts:

[0044]

[0045]

[0046] Example 9

[0047] A sebum mimicking composition comprising the following components in mass parts:

[0048]

[0049] The sebum mimicking composition of Examples 2-9 above were prepared in the same manner as Example 1.

[0050] Comparative Example 1

[0051] The only difference compared to Example 2 is that squalane is not included in the sebum mimicking composition of this comparative example, and the other components, amounts and preparation method are the same as in Example 2.

[0052] Comparative Example 2

[0053] The only difference compared to Example 2 is that PEG-80 sorbitan laurate is not included in the sebum mimicking composition of this comparative example, and the other components, amounts and preparation method are the same as in Example 2.

[0054] Comparative Example 3

[0055] The only difference compared to Example 2 is that glycerol is not included in the sebum mimicking composition of this comparative example, and the other components, amounts and preparation method are the same as in Example 2.

[0056] Comparative Example 4

[0057] The only difference compared to Example 2 is that the sugar isomer is not included in the sebum mimicking composition of this comparative example, and the other components, amounts and preparation method are the same as in Example 2.

[0058] Comparative Example 5

[0059] The only difference compared to Example 2 is that glyceryl oleate is not included in the sebum mimicking composition of this comparative example, and the other components, amounts and preparation method are the same as in Example 2.

[0060] Comparative Example 6

[0061] The difference between the present comparative example and Example 2 is that squalane is replaced by Glycine Soja oil in the sebum biomimetic composition of the present comparative example, and other components, amounts and preparation method are the same as those of Example 2.

[0062] Comparative Example 7

[0063] The difference between the present comparative example and Example 2 is that PEG-80 sorbitan laurate is replaced by disodium cocoyl glutamate in the sebum biomimetic composition of the present comparative example, and other components, amounts and preparation method are the same as those of Example 2.

[0064] Comparative Example 8

[0065] The difference between the present comparative example and Example 2 is that glycerin is replaced by propylene glycol in the sebum biomimetic composition of the present comparative example, and other components, amounts and preparation method are the same as those of Example 2.

[0066] Comparative Example 9

[0067] The difference between the present comparative example and Example 2 is that saccharide isomerate is replaced by sodium hyaluronate in the sebum biomimetic composition of the present comparative example, and other components, amounts and preparation method are the same as those of Example 2.

[0068] Comparative Example 10

[0069] The difference between the present comparative example and Example 2 is that glyceryl oleate is replaced by caprylic / capric triglyceride in the sebum biomimetic composition of the present comparative example, and other components, amounts and preparation method are the same as those of Example 2.

[0070] Application Example 1

[0071] A bubble bath, the formula of which is shown in Table 1.

[0072] Table 1 Bubble bath formula

[0073]

[0074]

[0075] The preparation method of the bubble bath of Application Example 1 is as follows:

[0076] S1. Add water of A phase and D phase into an emulsifying kettle, homogenously stir and disperse uniformly;

[0077] S2. Add PEG-80 sorbitan laurate, glycerin and glyceryl oleate of B phase into the mixture of step S1, add disodium EDTA of D phase at high temperature of 80-85℃, homogenously stir for about 20 min, keep warm for about 10 min, stir uniformly and start to cool down;

[0078] S3. The material of step S2 is cooled to about 60°C, and C phase (previously mixed and dissolved) is added, and the cooling is continued;

[0079] S4. The material of step S3 is cooled to about 38°C, and the squalane and sugar isomer of B phase are added, then the essence of D phase is added, and the pH is adjusted to 5-6 with pH adjuster (citric acid and sodium citrate).

[0080] Application Example 2

[0081] Compared with application example 1, the difference is that the sebum biomimetic composition prepared in example 1 is replaced by the sebum biomimetic composition prepared in example 2, and the addition amount of the sebum biomimetic composition prepared in example 2 is 20wt%, and other components, amounts and preparation methods are the same as application example 1.

[0082] Application Example 3

[0083] Compared with application example 1, the difference is that the sebum biomimetic composition prepared in example 1 is replaced by the sebum biomimetic composition prepared in example 3, and the addition amount of the sebum biomimetic composition prepared in example 3 is 13wt%, and other components, amounts and preparation methods are the same as application example 1.

[0084] Application Example 4

[0085] Compared with application example 1, the difference is that the sebum biomimetic composition prepared in example 1 is replaced by the sebum biomimetic composition prepared in example 4, and the addition amount of the sebum biomimetic composition prepared in example 4 is 50wt%, and other components, amounts and preparation methods are the same as application example 1.

[0086] Application Example 5

[0087] Compared with application example 1, the difference is that the sebum biomimetic composition prepared in example 1 is replaced by the sebum biomimetic composition prepared in example 4, and the addition amount of the sebum biomimetic composition prepared in example 4 is 5wt%, and other components, amounts and preparation methods are the same as application example 1.

[0088] Application Comparative Example 1

[0089] Compared with application example 2, the difference is only that the sebum biomimetic composition prepared in example 2 is removed, and other components, amounts and preparation methods are the same as application example 2.

[0090] Application Comparative Example 2

[0091] Compared with application example 2, the difference is only that the sebum biomimetic composition prepared in example 2 is replaced by the sebum biomimetic composition prepared in comparative example 1, and other components, amounts and preparation methods are the same as application example 2.

[0092] Application Comparative Example 3

[0093] Comparative Example 3 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 2.

[0094] Application Comparative Example 4

[0095] Comparative Example 4 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 3.

[0096] Application Comparative Example 5

[0097] Comparative Example 5 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 4.

[0098] Application Comparative Example 6

[0099] Comparative Example 6 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 5.

[0100] Application Comparative Example 7

[0101] Comparative Example 7 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 6.

[0102] Application Comparative Example 8

[0103] Comparative Example 8 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 7.

[0104] Application Comparative Example 9

[0105] Comparative Example 9 was prepared in the same manner as Application Example 2, except that the sebum biomimetic composition prepared in Example 2 was replaced with the sebum biomimetic composition prepared in Comparative Example 8.

[0106] Application Comparative Example 10

[0107] The difference between the application example 2 and the application example 3 is that the sebum mimicking composition prepared in the application example 2 is replaced by the sebum mimicking composition prepared in the comparative example 9, and other components, amounts and preparation methods are the same as those in the application example 2.

[0108] The application comparative example 11

[0109] The difference between the application example 2 and the application example 3 is that the sebum mimicking composition prepared in the application example 2 is replaced by the sebum mimicking composition prepared in the comparative example 9, and other components, amounts and preparation methods are the same as those in the application example 2.

[0110] Mildness test

[0111] Human patch test

[0112] 1. Test substance: the bubble bath of the application examples 1-5 and the bubble bath of the application comparative examples 1-11;

[0113] 2. Test subject: 60 people in total, 27 males and 33 females, aged 20-55 years old, randomly divided into two groups (30 people in each group), meeting the voluntary selection criteria of the test subject;

[0114] 3. Test method: using a closed test method, the test substance is placed in a suitable patch tester, and is attached to the curved side of the arm of the test subject with a low-sensitization adhesive tape, and is evenly attached to the skin with a palm, and is continuously attached for 24 hours; the blank control group does not use the product;

[0115] 4. Observation result: the test device is removed after 24 hours, and the skin reaction is observed after 0.5 hours, 24 hours and 48 hours, and the reaction result is recorded. The skin adverse reaction grade is shown in Table 2, and the test result is shown in Table 3.

[0116] Table 2 Skin reaction grading standard of skin closed patch test

[0117]

[0118]

[0119] Table 3 Results of human skin patch test

[0120]

[0121]

[0122]

[0123] As can be seen from Table 3, among the 30 subjects, there were 0 cases of skin adverse reactions in the application example 1, the application example 2, the application example 3, the application example 4, the application example 5, the application comparative example 2, the application comparative example 3, the application comparative example 5, the application comparative example 6, the application comparative example 7, the application comparative example 9, the application comparative example 10 and the application comparative example 11, and there was 1 case of 1-grade adverse reaction in the application comparative example 1, the application comparative example 4 and the application comparative example 8.

[0124] Compared with the application comparative example 1, the application comparative example 4 and the application comparative example 8, the application example 1, the application example 2, the application example 3, the application example 4 and the application example 5 have no adverse reaction, and there is 1 case of 1-grade adverse reaction in the application comparative example 1, the application comparative example 4 and the application comparative example 8, and the bubble bath formula added with the sebum biomimetic composition of the application is more mild. It is shown that the sebum biomimetic composition of the application has a synergistic effect after being combined scientifically, and is suitable for infant and child washing and caring products.

[0125] Performance test

[0126] Preservative challenge experiment

[0127] The preservative challenge experiment (the experiment is carried out according to the method of European Pharmacopoeia (EP7.0), and the test results are shown in Table 4).

[0128] Table 4 Preservative challenge experiment

[0129]

[0130]

[0131]

[0132] As can be seen from Table 4, the bubble bath of the application examples 1-5 of the application all pass the preservative challenge test, simulate the microbial pollution in the process of cosmetic production and use, so as to avoid the harm that may be caused to consumers in the process of using the product. It is shown that the safety of the bubble bath of the application is good.

[0133] Stability test

[0134] The bubble bath of the application examples 1-5 is subjected to the stability test, and the results are shown in Table 5 and Table 6.

[0135] Table 5

[0136]

[0137]

[0138] Table 6

[0139]

[0140] From the data in Table 5, Table 6, it can be seen that the products of application examples 1-5 can pass the stability test under the conditions of -15℃, 5℃, room temperature (22℃±2℃), light, 48℃, respectively.

[0141] Efficacy evaluation

[0142] Acute eye irritation test

[0143] 1. Experimental animals: 48 New Zealand white rabbits of ordinary level, weighing 1.80 kg to 2.20 kg, the animals were quarantined for at least 3 days before the test, and were used after passing the test.

[0144] 2. Test method:

[0145] 2.1 Check the two eyes of the experimental rabbits 24 hours before the start of the test (including the use of fluorescein sodium), and use the qualified rabbits for the test.

[0146] 2.2 Gently pull the lower eyelid of one side of the rabbit's eye, and drop 0.1 mL of the test substance into the conjunctival sac, so that the upper and lower eyelids are passively closed for 1 s, and then use a sufficient amount of water flow with a faster flow rate but without causing eye damage to the animal to flush for 30 s. The other side of the eye is flushed with pure water for 30 s as a self-control.

[0147] 2.3 Check the eyes of the animals at 1 h, 24 h, 48 h and 72 h after the test substance is dropped. After the 24 h observation and recording is completed, further check the eyes of all animals with fluorescein sodium. In each check, record the integral of eye irritation reaction according to the scoring standard of Table 1 of acute eye irritation / corrosion test in the Cosmetic Safety Technical Specification (2015 edition). The highest integral average of the irritation reaction of the cornea, iris or conjunctiva of the animals after being given the test substance at the 24 h, 48 h or 72 h observation time points and the recovery time are evaluated, and the irritation intensity of the test substance to the eye is determined according to Table 3 of the acute eye irritation / corrosion test in the Cosmetic Safety Technical Specification (2015 edition).

[0148] 3. Test results

[0149] Application examples 1-5 and application comparative examples 1-11 were used as samples for testing, and the test results are shown in Tables 7-10.

[0150] Table 7 Results of acute eye irritation test of test substance on rabbits (application example 1)

[0151]

[0152] Acute eye irritation to rabbits: Under the test conditions, the 30 s flush test result was non-irritating; the test results for Test Examples 2-5 were the same as for Test Example 1 and are not listed here.

[0153] Table 8 Test results for acute eye irritation to rabbits (Test Comparative Example 1)

[0154]

[0155] Acute eye irritation to rabbits: Under the test conditions, the 30 s flush test result was slightly irritating; the test results for Test Comparative Example 4, Test Comparative Example 8, and Test Comparative Example 9 were the same as for Test Comparative Example 1 and are not listed here.

[0156] Table 9 Test results for acute eye irritation to rabbits (Test Comparative Example 2)

[0157]

[0158]

[0159] Acute eye irritation to rabbits: Under the test conditions, the 30 s flush test result was slightly irritating; the test results for Test Comparative Example 4, Test Comparative Example 8, and Test Comparative Example 9 were the same as for Test Comparative Example 1 and are not listed here.

[0160] Table 10 Test results for acute eye irritation to rabbits (Test Comparative Example 3)

[0161]

[0162] Acute eye irritation to rabbits: Under the test conditions, the 30 s flush test result was slightly irritating; the test results for Test Comparative Example 4, Test Comparative Example 8, and Test Comparative Example 9 were the same as for Test Comparative Example 1 and are not listed here.

[0163] From the above results of the acute eye irritation test to rabbits, it can be seen that:

[0164] Test Example 1, Test Example 2, Test Example 3, Test Example 4, and Test Example 5 were compared with Test Comparative Example 1, which did not contain the sebum mimicking composition, and the result was slightly irritating, while Test Example 1, Test Example 2, Test Example 3, Test Example 4, and Test Example 5 were all non-irritating, indicating that the sebum mimicking composition can reduce the irritation of the surfactant system.

[0165] Comparative Application Example 2, Comparative Application Example 3, Comparative Application Example 4, Comparative Application Example 5, Comparative Application Example 6 and Application Example 2, the sebum biomimetic composition in Comparative Application Example 2, Comparative Application Example 3, Comparative Application Example 4, Comparative Application Example 5, Comparative Application Example 6 lacks an individual component, specifically, the sebum biomimetic composition in Comparative Application Example 2 does not include squalane, the sebum biomimetic composition in Comparative Application Example 3 does not include PEG-80 sorbitan laurate, the sebum biomimetic composition in Comparative Application Example 4 does not include glycerin, the sebum biomimetic composition in Comparative Application Example 5 does not include saccharide isomerate, and the sebum biomimetic composition in Comparative Application Example 6 does not include glyceryl oleate. The results of Comparative Application Example 2, Comparative Application Example 3, Comparative Application Example 5, Comparative Application Example 6 are slightly irritating, Comparative Application Example 4 is mildly irritating, and Application Example 2 is non-irritating, indicating that the sebum biomimetic composition of the present application has a synergistic effect of reducing irritation.

[0166] Comparative Application Example 7, Comparative Application Example 8, Comparative Application Example 9, Comparative Application Example 10, Comparative Application Example 11 and Application Example 2, Comparative Application Example 7, Comparative Application Example 8, Comparative Application Example 9, Comparative Application Example 10, Comparative Application Example 11 use similar substances to replace individual components in the sebum biomimetic composition, specifically, the sebum biomimetic composition in Comparative Application Example 7 replaces squalane with wild soybean (GLYCINE SOJA) oil, the sebum biomimetic composition in Comparative Application Example 8 replaces PEG-80 sorbitan laurate with disodium cocoyl glutamate, the sebum biomimetic composition in Comparative Application Example 9 replaces glycerin with propylene glycol, the sebum biomimetic composition in Comparative Application Example 10 replaces saccharide isomerate with sodium hyaluronate, and the sebum biomimetic composition in Comparative Application Example 11 replaces glyceryl oleate with caprylic / capric triglyceride. As a result, Comparative Application Example 8 and Comparative Application Example 9 are mildly irritating, Comparative Application Example 7, Comparative Application Example 10, and Comparative Application Example 11 are slightly irritating, and Application Example 2 is non-irritating, indicating that the sebum biomimetic composition of the present application is reasonable and has a synergistic effect of reducing irritation.

[0167] Instrumental efficacy evaluation, human sensory evaluation

[0168] Experimental purpose: qualitative and quantitative measurement and analysis of different dimensions of the characteristics of the sample by instrument and sensory evaluation.

[0169] The subjects were measured for the water content, transdermal water loss rate (randomly for the left and right hands), and oil content on the front chest at a distance of about 10 cm from the palm of the hand on the first day under conditions of a temperature of 21±1°C and a humidity of 50±10%, after waiting for 20 min. After the test was completed, the subjects took the samples home and used them every night. On the 28th day after use, the water content, transdermal water loss rate, and oil content on the front chest at a distance of about 10 cm from the palm of the hand were measured under conditions of a temperature of 21±1°C and a humidity of 50±10%, after waiting for 20 min. The sensory evaluation of the sample on human skin was also evaluated. The tester scored according to the feeling of use, with a 10-point scoring system, 1 point - very low degree, 3 points - low degree, 5 points - general degree, 7 points - high degree, and 10 points - very high degree. The comfort score (0 = very uncomfortable, 10 = comfortable), the overall evaluation score (0 = not satisfied, 10 = satisfied), and the final results are shown in Table 11.

[0170] Table 11

[0171]

[0172]

[0173] As can be seen from Table 11, the bubble bath of the present application has greater advantages compared with commercially available bubble baths. The transdermal water loss rate is significantly reduced, the water content of the skin is increased, indicating that the sebum biomimetic composition of the present application has the function of enhancing the skin barrier, the oil content of the skin is also increased, indicating that it also has a certain fat-enriching effect, and the skin comfort is significantly improved, and is generally loved by the testers.

[0174] The application comparative example 1 differs from the application example 2 in that it does not contain a sebum biomimetic composition. After use of the bubble bath, the skin water content, transdermal water loss rate, skin oil content, comfort, overall evaluation, and other aspects of the use effect are poorer.

[0175] The application comparative example 2 differs from the application example 2 in that it does not contain squalane. After use of the bubble bath, the scores for skin water content, comfort, overall evaluation, and other aspects are poorer, and the effect on the oil content of the skin is not significant.

[0176] The application comparative example 3 differs from the application example 2 in that it does not contain PEG-80 sorbitan laurate. After use of the bubble bath, the scores for skin water content, comfort, overall evaluation, and other aspects are poorer.

[0177] The application comparative example 4 differs from the application example 2 in that it does not contain glycerol. After use of the bubble bath, the skin water content is lower, the scores for comfort, overall evaluation, and other aspects are poorer, and the transdermal water loss rate is reduced less.

[0178] The application comparative example 5 is different from the application example 2 in that no sugar isomer is contained, the skin water content is lower after use of the bubble bath, the scores of comfort, overall evaluation and the like are poorer, the decrease in transdermal water loss is less, and the effect on the skin oil content is not significant.

[0179] The application comparative example 6 is different from the application example 2 in that no glyceryl oleate is contained, the skin water content is lower after use of the bubble bath, the scores of comfort, overall evaluation and the like are poorer, and the effect on the skin oil content is not significant.

[0180] The application comparative example 7 is different from the application example 2 in that the squalane is replaced by Glycine soja oil, the skin water content is lower after use of the bubble bath, the scores of comfort, overall evaluation and the like are poorer, and the effect on the skin oil content is not significant.

[0181] The application comparative example 8 is different from the application example 2 in that the PEG-80 sorbitan laurate is replaced by disodium cocoyl glutamate, the skin water content is lower, the scores of comfort, overall evaluation and the like are poorer, the decrease in transdermal water loss is less, and the effect on the skin oil content is not significant.

[0182] The application comparative example 9 is different from the application example 2 in that the glycerol is replaced by propylene glycol, the skin water content is lower after use of the bubble bath, the scores of comfort, overall evaluation and the like are poorer, the decrease in transdermal water loss is less, and the effect on the skin oil content is not significant.

[0183] The application comparative example 10 is different from the application example 2 in that the sugar isomer is replaced by sodium hyaluronate, the scores of skin water content, comfort, overall evaluation and the like are poorer after use of the bubble bath.

[0184] The application comparative example 11 is different from the application example 2 in that the glyceryl oleate is replaced by caprylic / capric triglyceride, the scores of skin water content, comfort, overall evaluation and the like are poorer after use of the bubble bath, and the effect on the skin oil content is not significant.

[0185] The above data show that the addition of the sebum biomimetic composition of the application can better reduce the transdermal water loss of the skin, enhance the skin barrier repair, increase the skin water content, greatly improve the comfort of the skin, significantly increase the skin sebum content, and has a high overall use satisfaction. Replacing the components in the sebum biomimetic composition of the application with similar functional components cannot achieve satisfactory results.

[0186] The application of the sebum biomimetic composition of the application to the washing and care products, especially baby and child washing and care products, can achieve a good effect of reducing irritation and reducing the damage to the skin caused by surfactants and active substances.

[0187] In summary, the bubble bath of the present application has a good use feeling, has the effects of moisturizing, fat enrichment, skin barrier strengthening, irritation reduction, etc., and the several components of the sebum biomimetic composition in the bubble bath formula of the present application have a synergistic effect, and the overall use effect is good.

[0188] The preferred embodiments of the present application are specifically described above, but the present application is not limited to the described embodiments, and those skilled in the art can make various equivalent modifications or replacements without departing from the spirit of the present application, and these equivalent modifications or replacements are all included in the scope defined by the claims of the present application.

Claims

1. A biomimetic composition for sebum, characterized in that, The biomimetic sebum composition comprises, by weight, 5-20 parts of squalane, 20-40 parts of PEG-80 sorbitan laurate, 20-40 parts of glycerin, 20-40 parts of saccharide isomers, and 5-20 parts of glyceryl oleate.

2. The sebum-inspired biomimetic composition according to claim 1, characterized in that, The biomimetic sebum composition comprises, by weight, 10-20 parts of squalane, 30-40 parts of PEG-80 sorbitan laurate, 30-40 parts of glycerin, 25-40 parts of saccharide isomers, and 9-20 parts of glyceryl oleate.

3. The method for preparing the sebum-inspired biomimetic composition according to claim 1 or 2, characterized in that, Includes the following steps: The squalane, PEG-80 sorbitan laurate, glycerol, sugar isomers, and glyceryl oleate are mixed to obtain the sebum biomimetic composition.

4. A washing and care product, characterized in that, Includes the sebum-inspired composition according to claim 1 or 2.

5. The washing and care product according to claim 4, characterized in that, The amount of the sebum biomimetic composition added is 0.01-50 wt%.

6. The washing and care product according to claim 5, characterized in that, The amount of the sebum-inspired composition added is 5-50 wt%.

7. The washing and care product according to claim 4, characterized in that, The aforementioned washing and care products are baby and child washing and care products.

8. A bubble bath gel, characterized in that, This includes the sebum-inspired composition as described in claim 1 or 2, as well as cosmetic excipients.

9. The bubble bath gel according to claim 8, characterized in that, The excipients include at least one of surfactants, pH adjusters, preservatives, and chelating agents.

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