A Chinese medicine composition with soothing and anti-aging effects and its application

Abstract

The invention discloses a Chinese medicine composition with soothing and anti-aging effects, wherein the raw materials of the active ingredients of the Chinese medicine composition are: sophora flavescens, schizonepeta tenuifolia, siler, centella asiatica, and tetrandra teparata. The Chinese medicine composition of the invention achieves skin soothing, repairing and anti-aging effects through compounding of the components and synergistic enhancement. In the skin elasticity test, the composition has obvious improvement on the skin, and the composition is mild and safe, has soothing and repairing effects on people with sensitive skin, and does not contain hormones, antihistamines, etc., thereby avoiding the irritation and sensitization of chemical agents on the skin.

Description

Technical Field

[0001] The present invention relates to a Chinese medicine composition, in particular to a Chinese medicine composition with soothing and anti-aging effects and application thereof. Background Art

[0002] Skin aging is caused by natural or unnatural factors, and is manifested as skin sagging, wrinkles, vascular dilation, poor epidermal keratinization, abnormal proliferation, dermal elastic fiber degeneration and accumulation of degradation products. With the increase of age and the influence of environmental factors, collagen activity decreases, elasticity decreases, and the ability to absorb and retain moisture weakens, causing the skin to lose tension and elasticity and become dry and rough. With the increasing aging of society and people's pursuit of youth, the share of anti-aging skin care products in the cosmetics market has gradually increased, but the anti-aging products on the market are of varying quality, and many products are not ideal, especially for people with sensitive skin. It is more difficult to find suitable products. In addition, most skin care products often add some chemicals to improve the efficacy of short-term use. These skin care products may have the characteristics of fast effect, but they cannot fundamentally improve skin problems. They are prone to objective symptoms such as erythema, papules, and capillary dilation accompanied by subjective symptoms such as itching, stinging, burning, and tightness. Among these symptoms, itching is one of the most difficult to suppress and tolerate. Itching usually refers to the desire of the skin to scratch in response to stimulation.

[0003] CN109010423A discloses a soothing composition, which includes, by weight, 0.5-20 parts of milk thistle fruit alcohol extract for inhibiting the production of cellular inflammatory factors, 0.5-20 parts of holy basil leaf alcohol extract for inhibiting the production of cellular inflammatory factors, 15-45 parts of upland cotton water extract for improving DNA repair, and 25-40 parts of mushroom alcohol extract for skin moisturizing and accelerating skin barrier repair. Its technical effect is: it can well soothe allergic parts and enhance the effect of skin barrier.

[0004] CN108354863A discloses a soothing and repairing composition, which contains the following raw materials: Astragalus membranaceus root extract, Atractylodes macrocephala rhizome extract, and Albizzia julibrissin bark extract. The mass ratio of the Astragalus membranaceus root extract, Atractylodes macrocephala rhizome extract, and Albizzia julibrissin bark extract is (1-10): (1-10): (1-10). The soothing and repairing composition of the invention has the triple skin care effects of inhibiting inflammation, reducing red blood streaks, and strengthening the skin barrier, and has a good effect of repairing sensitive skin when used for a long time.

[0005] These soothing compositions are generally used after allergies occur due to the use of cosmetics, and are a remedy to some extent. If the irritation of cosmetics can be reduced, the allergic reactions caused by the use of cosmetics can be reduced as much as possible, and at the same time, anti-aging effects can be achieved, it will be more realistic. Summary of the invention

[0006] The purpose of the present invention is to overcome at least one of the shortcomings of the prior art and to provide a Chinese medicine composition with soothing and anti-aging effects and its application.

[0007] The technical solution adopted by the present invention is:

[0008] In a first aspect, the present invention provides a traditional Chinese medicine composition with soothing and anti-aging effects, wherein the raw materials of the active ingredients are: Sophora flavescens, Schizonepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica, and Stephania tetrandra.

[0009] In some examples, the active ingredient is an aqueous extract of the raw material.

[0010] In some examples, the mass ratio of the raw materials of the active ingredients is: 5-12 parts of Sophora flavescens, 4-10 parts of Schizonepeta tenuifolia, 5-15 parts of Saposhnikovia divaricata, 1-3 parts of Centella asiatica, and 1-3 parts of Stephania tetrandra.

[0011] In some examples, the mass ratio of the raw materials of the active ingredients is: 8 parts of Sophora flavescens, 7 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 2 parts of Centella asiatica, and 2 parts of Stephania tetrandra.

[0012] In some examples, the method for preparing the Chinese medicine composition comprises the following steps:

[0013] 1) Grind and sieve Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra to obtain a medicinal material powder mixture;

[0014] 2) extracting the medicinal material powder mixture obtained in step 1 by water, adding 20 to 40 times of deionized water, stirring at a speed of 60 to 80 rpm, at an extraction temperature of 25 to 65° C., and for 60 to 120 min, then performing solid-liquid separation on the obtained extract material, and collecting the extract;

[0015] 3) placing the extract collected in step 2 in a container, adding 10-20% of the weight of the extract to a macroporous anion exchange resin containing a quaternary amine functional group, stirring and adsorbing for 2-4 hours, and then performing solid-liquid separation to obtain a refined liquid;

[0016] 4) The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 200-500 nm, purified by an ultrafiltration membrane with a pore size of 5000-8000 dal, and concentrated by a nanofiltration membrane with a pore size of 80-100 dal, and 1-2 times the weight of the medicinal material powder mixture in step 1 is collected to obtain a traditional Chinese medicine composition.

[0017] In a second aspect, the present invention provides a skin care product additive, comprising an auxiliary material and an active ingredient, wherein the active ingredient is the traditional Chinese medicine composition described in the first aspect.

[0018] In some examples, the excipients include propylene glycol, butylene glycol, tetrahydropiperine, a preservative, and water.

[0019] In a third aspect, the present invention provides a soothing and anti-aging skin care product, comprising auxiliary materials and functional ingredients, wherein the functional ingredients include the skin care product additives described in the second aspect.

[0020] In some examples, the added amount of the skin care product additive is 0.1-10% by weight.

[0021] In some examples, the skin care product is a cream, lotion, water, serum, gel or mask.

[0022] The beneficial effects of the present invention are:

[0023] 1) The Chinese medicine composition of the present invention achieves anti-aging of the skin through the synergistic effect of the various components. The composition has a significant improvement on the skin in the skin elasticity test. The composition is mild and safe, and has a soothing and repairing effect on people with sensitive skin;

[0024] 2) The Chinese medicine composition of the present invention can effectively relieve sensitive skin from external stimulation, does not contain hormones, antihistamines, etc., thereby avoiding the stimulation and sensitization of chemical agents on the skin. DETAILED DESCRIPTION

[0025] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0026] Sophora flavescens: Sophora flavescens has the effects of clearing away heat and dampness, anti-inflammatory and antipruritic, and has been the main medicine for treating eczema and dermatitis since ancient times. The "Compendium of Materia Medica" commented that Sophora flavescens "is the most commonly used medicine for treating sores and rashes in ancient and modern times", and has a significant effect in treating acute eczema and dermatitis caused by damp heat, and has good curative effects for oral and topical use. Modern research: Sophora flavescens contains a variety of alkaloids and flavonoids. Matrine has the effect of reducing inflammatory reactions, and has anti-inflammatory and anti-allergic effects similar to corticosteroids.

[0027] Schizonepeta: spicy, slightly warm. Enters the lung and liver meridians. Relieves exterior symptoms, dispels wind, clears rashes, and eliminates sores. Used for colds, headaches, measles, rubella, and the initial stage of sores.

[0028] Saposhnikovia root: pungent, sweet, slightly warm in nature. It enters the bladder, lung, spleen, and liver meridians. It has the effects of dispelling wind and relieving exterior symptoms, removing dampness and relieving pain. It is used for external symptoms, urticaria itching, rheumatic pain, tetanus, spleen deficiency and dampness.

[0029] Centella asiatica: The dried whole herb of Centella asiatica L. Urban, a plant of the genus Centella in the family Apiaceae. Centella asiatica is cold in nature, bitter and pungent in taste, and has the effects of clearing away heat and dampness, detoxifying and reducing swelling. It is clinically used for traumatic injuries, infectious hepatitis, epidemic cerebrospinal meningitis, etc. The asiaticoside contained in it is used to treat skin diseases, trauma, renal failure, etc. Modern pharmacological studies have shown that Centella asiatica has the effects of inhibiting scar hyperplasia, anti-tumor, anti-ulcer, anti-inflammatory, and anti-oxidation.

[0030] Stephania tetrandra: Stephania tetrandra is the dried root of Stephania tetrandra S.Moore of the Menispermaceae family. Stephania tetrandra tastes bitter and is cold in nature. It enters the bladder and lung meridians and has the effects of promoting diuresis, reducing swelling, dispelling wind and relieving pain. It can also be used to treat edema, athlete's foot, dysuria, rheumatism, eczema, sores, hypertension and other symptoms. Stephania tetrandra contains active ingredients such as alkaloids and flavonoids. Modern pharmacological research shows that it has pharmacological effects such as anti-tumor, anti-free radical damage, antibacterial and antiviral.

[0031] The mass fraction compositions of the Chinese medicine compositions in the embodiments and comparative examples of the present invention are shown in Table 1. In comparative example 14, Sophora flavescens was replaced by Phellodendron amurense with similar efficacy; and in comparative example 15, Stephania tetrandra was replaced by Coix lachryma-jobi with similar efficacy.

[0032] Table 1 Composition of Chinese medicine composition by weight

[0033]

[0034] Example 1

[0035] The preparation method of the Chinese medicine composition with soothing and anti-aging effects comprises the following steps in sequence:

[0036] Step 1: Weigh Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra, grind them separately and pass through 80 mesh, mix the grinded medicinal material powders evenly to obtain a medicinal material powder mixture.

[0037] Step 2: Place the medicinal powder obtained in step 1 in a Chinese herbal medicine directional extraction device, add 30 times of deionized water by weight, stir at 70 rpm, extract at 40°C, and extract for 90 minutes. The obtained extract is separated into solid and liquid by centrifugation, and the extract is collected to obtain an extract.

[0038] Step 3: Place the extract collected in step 2 in a container, add 15% by weight of a macroporous anion exchange resin containing a quaternary amine functional group, stir and adsorb for 3 hours, perform solid-liquid separation, and obtain a refined liquid.

[0039] Step 4: The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 200 nm, purified by an ultrafiltration membrane with a pore size of 8000 dal, and concentrated by a nanofiltration membrane with a pore size of 100 dal. The obtained concentrated liquid is 1 times the weight ratio of the medicinal material powder mixture in step 1, and the obtained concentrated liquid is the Chinese medicine composition.

[0040] Example 2

[0041] The preparation method of the Chinese medicine composition with soothing and anti-aging effects comprises the following steps in sequence:

[0042] Step 1: Weigh Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra, grind them separately and pass through 60 mesh, mix the grinded medicinal material powders evenly to obtain a medicinal material powder mixture.

[0043] Step 2: Place the medicinal powder obtained in step 1 in a Chinese herbal medicine directional extraction device, add 20 times of deionized water by weight, stir at 60 rpm, extract at 25°C, and extract for 60 minutes. The obtained extract is filtered for solid-liquid separation, and the extract is collected to obtain an extract.

[0044] Step 3: Place the extract collected in step 2 in a container, add 20% by weight of a macroporous anion exchange resin containing a quaternary amine functional group, stir and adsorb for 4 hours, perform solid-liquid separation, and obtain a refined liquid.

[0045] Step 4: The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 500 nm, purified by an ultrafiltration membrane with a pore size of 8000 dal, and concentrated by a nanofiltration membrane with a pore size of 100 dal. The obtained concentrated liquid is 1 times the weight ratio of the medicinal material powder mixture in step 1, and the obtained concentrated liquid is the Chinese medicine composition.

[0046] Example 3

[0047] The preparation method of the Chinese medicine composition with soothing and anti-aging effects comprises the following steps in sequence:

[0048] Step 1: Weigh Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra, grind them separately and pass through 70 mesh, mix the grinded medicinal material powders evenly to obtain a medicinal material powder mixture.

[0049] Step 2: Place the medicinal powder obtained in step 1 in a Chinese herbal medicine directional extraction device, add 40 times of deionized water by weight, stir at 80 rpm, extract at 65°C, and extract for 120 min. The obtained extract is separated into solid and liquid by centrifugation, and the extract is collected to obtain an extract.

[0050] Step 3: Place the extract collected in step 2 in a container, add 10% by weight of a macroporous anion exchange resin containing a quaternary amine functional group, stir and adsorb for 2-4 hours, perform solid-liquid separation, and obtain a refined liquid.

[0051] Step 4: The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 200 nm, purified by an ultrafiltration membrane with a pore size of 5000 dal, and concentrated by a nanofiltration membrane with a pore size of 80 dal. The obtained concentrated liquid is twice the weight of the mixture of medicinal powders in step 1, and the concentrated liquid is the Chinese medicine composition.

[0052] Example 4

[0053] The preparation method of the Chinese medicine composition with soothing and anti-aging effects comprises the following steps in sequence:

[0054] Step 1: Weigh Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra, grind them separately and pass through 70 mesh, mix the grinded medicinal material powders evenly to obtain a medicinal material powder mixture.

[0055] Step 2: Place the medicinal powder obtained in step 1 in a Chinese herbal medicine directional extraction device, add 40 times of deionized water by weight, stir at 70 rpm, extract at 50°C, and extract for 100 min. The obtained extract is filtered for solid-liquid separation, and the extract is collected to obtain an extract.

[0056] Step 3: Place the extract collected in step 2 in a container, add 15% by weight of a macroporous anion exchange resin containing a quaternary amine functional group, stir and adsorb for 4 hours, perform solid-liquid separation, and obtain a refined liquid.

[0057] Step 4: The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 300 nm, purified by an ultrafiltration membrane with a pore size of 6000 dal, and concentrated by a nanofiltration membrane with a pore size of 100 dal. The obtained concentrated liquid is 1.5 times the weight ratio of the medicinal material powder mixture in step 1, and the obtained concentrated liquid is the Chinese medicine composition.

[0058] Example 5

[0059] A traditional Chinese medicine composition with soothing and anti-aging effects and a preparation method thereof, which is prepared from the following components in weight ratio: 8 parts of sophora flavescens, 4 parts of schizonepeta tenuifolia, 9 parts of siler, 1 part of centella asiatica and 2 parts of tetrandra stephania tetrandra.

[0060] The preparation method of the Chinese medicine composition with soothing and anti-aging effects comprises the following steps in sequence:

[0061] Step 1: Weigh Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra, grind them separately and pass through 60-100 mesh, mix the grinded medicinal material powders evenly to obtain a medicinal material powder mixture.

[0062] Step 2: Place the medicinal powder obtained in step 1 in a Chinese herbal medicine directional extraction device, add 30 times of deionized water by weight, stir at 60-80 rpm, extract at 25°C, and extract for 90 minutes. The obtained extract is filtered for solid-liquid separation, and the extract is collected to obtain an extract.

[0063] Step 3: Place the extract collected in step 2 in a container, add 10% by weight of a macroporous anion exchange resin containing a quaternary amine functional group, stir and adsorb for 3 hours, perform solid-liquid separation, and obtain a refined liquid.

[0064] Step 4: The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 200 nm, purified by an ultrafiltration membrane with a pore size of 6000 dal, and concentrated by a nanofiltration membrane with a pore size of 80 dal. The obtained concentrated liquid is 1 times the weight ratio of the medicinal powder mixture in step 1, and a concentrated liquid is obtained.

[0065] Step 5: Dry the concentrated liquid collected in step 4 into solid powder, which is the Chinese medicine composition.

[0066] Example 6

[0067] Step 2 of the preparation method of the Chinese medicine composition is to add 10 times of deionized water, and the extraction time is 45 minutes. The rest is the same as Example 1.

[0068] Example 7

[0069] In step 4 of the method for preparing the Chinese medicine composition, separation is performed using a ceramic membrane with a diameter of 800 nm and purification is performed using an ultrafiltration membrane with a pore size of 30,000 dal. The rest is the same as in Example 1.

[0070] The preparation methods of the Chinese medicine compositions of Comparative Examples 1 to 15 are the same as that of Example 1.

[0071] Then, the Chinese medicine compositions obtained in Examples 1 to 7 and Comparative Examples 1 to 15 were taken and the corresponding essences were prepared according to the formula in Table 2.

[0072] Table 2 Plant composition essence formula

[0073]

[0074] The method for preparing the essence is as follows: fully stir phase A and mix evenly. Under stirring conditions, slowly add the pre-dissolved group B into group A and continue stirring for 30 minutes. Cool to room temperature to obtain the essence.

[0075] Comparative experiment on hyaluronidase inhibition effect

[0076] Hyaluronidase is a participant in allergic reactions. It is strongly related to inflammation and allergies. Many anti-allergic drugs work by inhibiting the activity of hyaluronidase. Therefore, the inhibition of hyaluronidase activity can be used as an indicator of the anti-allergic effect of cosmetics.

[0077] This test uses the Elson-Morgan modified method: hyaluronidase hydrolyzes hyaluronic acid to produce β-N-acetylglucosamine, which condenses with acetylacetone under alkaline conditions to produce 2-methyl-3-diacetylpyrrole derivatives, and 2-methyl-3-diacetylpyrrole derivatives react with p-dimethylaminobenzaldehyde in concentrated hydrochloric acid ethanol solution. The reactants have characteristic absorption at 530nm, and the change in absorbance is linearly correlated with the degree of inhibition of hyaluronidase activity. By measuring the change in absorbance, the hyaluronidase inhibition rate can be calculated, thereby analyzing the anti-allergic activity of cosmetics.

[0078] Take 0.1mL of 0.25mmol / LCaCl2 solution and 0.5mL of hyaluronidase solution and incubate at 37℃ for 20min; add 0.5mL of the plant composition and continue to incubate at 37℃ for 20min; add 0.5mL of sodium hyaluronate solution and incubate at 37℃ for 30min, and place at room temperature for 5min; add 0.1mL of 0.4mol / LNaOH solution and 0.5mL of acetylacetone solution, heat in a boiling water bath for 15min, and immediately cool with ice water for 5min; add 1.0mL of Ehrlich reagent and dilute with 3.0mL of anhydrous ethanol, place for 20min to develop color, and determine the absorbance value (ABS value) with a spectrophotometer. The hyaluronidase inhibition rate is calculated as follows.

[0079]

[0080] Wherein: A is the ABS value of the control solution; B is the ABS value of the control blank solution; C is the ABS value of the sample solution; D is the ABS value of the sample blank solution.

[0081] During the experiment, the sample of Example 1 was first scanned in the wavelength range of 450-700 nm to determine the maximum absorption wavelength, and then the ABS values ​​of all comparative examples were measured at the maximum absorption wavelength using deionized water as a reference.

[0082] The comparison of the hyaluronidase inhibition effects of Examples 1 to 7 and Comparative Examples 1 to 15 is shown in Table 3.

[0083] Table 3 Hyaluronidase inhibition results

[0084] Sample set Hyaluronidase inhibition rate (%) Sample set Hyaluronidase inhibition rate (%) Example 1 67.8 Comparative Example 5 21.6 Example 2 66.2 Comparative Example 6 43.5 Example 3 66.5 Comparative Example 7 45.1 Example 4 67.1 Comparative Example 8 42.8 Example 5 66.8 Comparative Example 9 49.6 Example 6 56.2 Comparative Example 10 39.4 Example 7 58.7 Comparative Example 11 25.7 Comparative Example 1 17.5 Comparative Example 12 27.2 Comparative Example 2 3.5 Comparative Example 13 32.6 Comparative Example 3 12.7 Comparative Example 14 27.3 Comparative Example 4 6.2 Comparative Example 15 29.6

[0085] As can be seen from Table 3, compared with the comparative example, under the same addition concentration conditions, the hyaluronidase inhibition rate of Examples 1 to 7 is significantly higher than that of the comparative example, indicating that the plant composition of the present invention has a significant anti-allergic effect. As can be seen from the comparative example test results, when the composition of the raw materials, the ratio between the raw materials, and the preparation process parameters do not fall within the scope of the present invention, the hyaluronidase inhibition rate will be greatly reduced. The research results of the hyaluronidase inhibition rate show that the Chinese medicine composition of the present invention has a significant hyaluronidase inhibition ability, has a clear synergistic effect, and shows a good anti-allergic effect.

[0086] Comparative experiment on skin elasticity effect test

[0087] As people age, their skin tends to sag and wrinkle, and their skin elasticity will also decrease. Therefore, human skin elasticity is one of the important indicators of human aging. The skin elasticity in this study is based on the principle of suction and stretching. Negative pressure is generated on the surface of the tested skin, and the depth of the skin sucked into the test probe is measured by a non-contact optical test system.

[0088] Test population: 66 healthy female subjects (35-55 years old) with facial problems such as dry lines, fine lines, sagging, and decreased skin elasticity were selected. The subjects were divided into 22 groups, 3 people in each group, and the average age of each group was controlled to be as close as possible.

[0089] Test method: After cleaning the skin with warm water, volunteers in each group evenly applied 3 ml of essence on the face and gently massaged with fingertips until completely absorbed. Use once a day in the morning and evening for 8 consecutive weeks. The skin elasticity parameter R2 of the cheek area of ​​the subjects was measured using the skin elasticity tester CutometerMPA580. The average value was taken after 3 measurements. R2 is the ratio of the skin's rebound amount when there is no negative pressure to the maximum stretch amount when there is negative pressure, indicating the degree to which the skin can recover within one cycle after being deformed by negative pressure. The closer the test value is to 1, the better the skin elasticity.

[0090] The essences prepared by the compositions of Examples 1 to 7 and Comparative Examples 1 to 15 were tested and compared for the effect of improving skin elasticity. The results are shown in Table 4.

[0091] Table 4 Skin elasticity effect test results

[0092]

[0093]

[0094] As can be seen from Table 4, after the essence was used for 8 weeks, the R2 value of the embodiment was significantly higher than that of the comparative example, indicating that the plant composition of the present invention has the effect of significantly improving skin elasticity. Compared with the comparative example products with different raw material group compositions, different raw material ratios, and different preparation processes, the R2 value of the Chinese medicine composition of the present invention is significantly improved, has a clear synergistic effect, and shows good anti-aging performance.

[0095] The above is a further detailed description of the present invention, which should not be regarded as a limitation on the specific implementation of the present invention. For ordinary technicians in the technical field to which the present invention belongs, simple deduction or replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A Chinese medicine composition with soothing and anti-aging effects, characterized in that: The mass ratio of the raw materials of the active ingredients is: 5-12 parts of Sophora flavescens, 4-10 parts of Schizonepeta tenuifolia, 5-15 parts of Saposhnikovia divaricata, 1-3 parts of Centella asiatica, and 1-3 parts of Stephania tetrandra; the active ingredients are water extracts of the raw materials, and the preparation method of the Chinese medicine composition comprises the following steps: 1) Grind and sieve Sophora flavescens, Nepeta tenuifolia, Saposhnikovia divaricata, Centella asiatica and Stephania tetrandra to obtain a medicinal material powder mixture; 2) extracting the medicinal material powder mixture obtained in step 1 by water, adding 20 to 40 times of deionized water, stirring at a speed of 60 to 80 rpm, at an extraction temperature of 25 to 65° C., and for 60 to 120 min, then performing solid-liquid separation on the obtained extract material, and collecting the extract; 3) placing the extract collected in step 2 in a container, adding 10-20% of the weight of the extract to a macroporous anion exchange resin containing a quaternary amine functional group, stirring and adsorbing for 2-4 hours, and then separating the solid and the liquid to obtain a refined liquid; 4) The refined liquid collected in step 3 is separated by a ceramic membrane with a pore size of 200-500 nm, purified by an ultrafiltration membrane with a pore size of 5000-8000 dal, and concentrated by a nanofiltration membrane with a pore size of 80-100 dal, and a concentrated liquid of 1-2 times the weight of the medicinal material powder mixture in step 1 is collected to obtain a traditional Chinese medicine composition.

2. The Chinese medicine composition according to claim 1, characterized in that: The mass ratio of the raw materials of the active ingredients is: 8 parts of Sophora flavescens, 7 parts of Schizonepeta tenuifolia, 10 parts of Saposhnikovia divaricata, 2 parts of Centella asiatica and 2 parts of Stephania tetrandra.

3. A skin care product additive, comprising auxiliary materials and active ingredients, characterized in that: The active ingredient is the Chinese medicine composition according to claim 1.

4. The skin care product additive according to claim 3, characterized in that: The auxiliary materials include propylene glycol, butylene glycol, tetrahydropiperine, a preservative and water.

5. A soothing and anti-aging skin care product, comprising auxiliary materials and functional ingredients, characterized in that: The functional ingredients include the skin care product additive according to claim 3.

6. The skin care product according to claim 5, characterized in that The added amount of the skin care product additive is 0.1 to 10%.

7. The skin care product according to claim 5, characterized in that: The skin care product is a cream, lotion, water solution, essence, gel or facial mask.

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