Scar softening solution and method of making same

Abstract

The application discloses a scar softening liquid and a preparation method thereof, and raw materials of the scar softening liquid include the following components in parts by weight: cassia twig 18-36 parts, white peony root 18-36 parts, rhubarb 18-36 parts, sophora flavescens 36-72 parts, zanthoxylum 36-72 parts, wormwood leaf 36-72 parts, cortex meliae 12-24 parts and fried tribulus terrestris 12-24 parts. The scar softening liquid is prepared by using Chinese herbal medicines as raw materials, can be used by external application, and can improve the scar hyperplasia by using the external treatment method of traditional Chinese medicine; when used by external application, the Chinese herbal medicines can penetrate into scar tissues to inhibit the scar hyperplasia, and then promote the scar softening and dispersion, and efficiently treat and inhibit the occurrence and development of the scar. The scar softening liquid is non-toxic, non-irritating, mild to the skin, brown, has moderate viscosity, and has no residue after wiping.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine treatment of scars, and in particular to a scar softening liquid and its preparation method. Background Technology

[0002] Scars refer to the general term for changes in the surface morphology and internal tissues of a wound during the healing process. They are generally classified into superficial scars, hypertrophic scars, atrophic scars, and keloids. In daily life, burns, cuts, infections, and other injuries to the dermis accelerate collagen synthesis, leading to fibroblast proliferation and the formation of hypertrophic scars. These scars are characterized by their reddish-purple color, raised appearance above normal skin, and are accompanied by symptoms such as itching and swelling. They are extremely difficult to heal in a short period of time, causing severe cosmetic and psychological impact on patients.

[0003] Currently, common scar repair methods include a combination of surgery, medication, pressure therapy, radiation, laser treatment, and physical rehabilitation. Among these methods, topical scar medications have become an important tool in scar repair in recent years due to their ease of use and good efficacy. There are many types of topical scar medications on the market, and their mechanisms of action differ. Foreign topical scar medications are generally more expensive, while domestically produced ones are relatively cheaper, but their scar repair effects are less satisfactory. Therefore, there is still huge market potential for the research and development of topical scar medications in China. Summary of the Invention

[0004] This invention provides a scar softening powder and its preparation method to solve the technical problem of poor scar repair effect in existing topical scar medications.

[0005] To achieve the above objectives, the technical solution provided by the present invention is as follows:

[0006] In a first aspect, the present invention provides a scar softening liquid, the raw materials of which include the following components in parts by weight: 18-36 parts of cinnamon twig, 18-36 parts of white peony root, 18-36 parts of rhubarb, 36-72 parts of sophora flavescens, 36-72 parts of Sichuan pepper, 36-72 parts of mugwort leaf, 12-24 parts of dictamnus dasycarpus root bark, and 12-24 parts of stir-fried tribulus terrestris.

[0007] Furthermore, its raw materials include the following components by weight: 27 parts cinnamon twig, 27 parts white peony root, 27 parts rhubarb, 54 parts sophora flavescens, 54 parts Sichuan pepper, 54 parts mugwort leaf, 18 parts dictamnus dasycarpus root bark, and 18 parts stir-fried tribulus terrestris.

[0008] In a second aspect, the present invention provides a method for preparing the above-mentioned scar softening liquid, comprising the following steps: weighing each component of the raw material according to the weight ratio, placing them in a container and soaking them in water, and then decocting them to obtain the scar softening liquid.

[0009] Furthermore, in the step of soaking in water, the soaking time is 15 min to 25 min, and the water volume is 5 cm to 10 cm higher than the raw material.

[0010] Furthermore, in the frying step, the frying is performed 2 to 3 times, and each frying time is 25 to 40 minutes.

[0011] Furthermore, the steps also include a step of sterilizing with ultraviolet light after the frying step.

[0012] The scar softening solution of this application requires the use of gauze. Specifically, a scar patch is made by soaking two layers of medical degreased gauze with the scar softening solution and applying it to the scar area, at a rate of 20mL / 100cm. 2 Apply externally twice daily for 30 minutes each time.

[0013] The scar softening liquid provided by this invention is made from traditional Chinese medicine herbs. It can be applied externally, using traditional Chinese medicine external treatment methods to improve scar hyperplasia. When applied externally, the herbs can penetrate deep into the scar tissue to inhibit scar hyperplasia, thereby promoting scar softening and dissipation, effectively treating and inhibiting the occurrence and development of scars. The above-mentioned scar softening liquid is non-toxic, non-irritating, gentle on the skin, yellowish-brown in color, with moderate viscosity, and leaves no residue after wiping. Detailed Implementation

[0014] To enable those skilled in the art to better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0015] In a first aspect of this application, a scar softening liquid is provided, the raw materials of which include the following components in parts by weight: 18-36 parts of cinnamon twig, 18-36 parts of white peony root, 18-36 parts of rhubarb, 36-72 parts of sophora flavescens, 36-72 parts of Sichuan pepper, 36-72 parts of mugwort leaf, 12-24 parts of dictamnus dasycarpus root bark, and 12-24 parts of stir-fried tribulus terrestris.

[0016] Cinnamon twig has the effects of inducing sweating and relieving muscle tension, warming and unblocking the meridians, assisting yang and promoting qi circulation, and calming and lowering qi. Cinnamon twig also possesses pharmacological activities such as vasodilating, antioxidant, and lipid-lowering effects. Among these, the volatile oil of cinnamon twig has a good antibacterial effect against Staphylococcus aureus and Escherichia coli. Its cinnamic acid has antibacterial and white blood cell-increasing pharmacological effects, 3,4-dihydroxybenzoic acid is an anti-inflammatory and antibacterial active ingredient in plants, and cinnamaldehyde has significant sedative, analgesic, and peripheral circulation-improving effects.

[0017] Paeonia lactiflora Pall. is described in "Supplementary Records of the Materia Medica" as follows: "It promotes smooth flow of blood vessels, soothes the middle energizer, scatters stasis, expels pathogenic blood, eliminates water qi, benefits the bladder, large intestine and small intestine, and dissipates carbuncles and swelling." Its chemical components mainly include volatile oils, monoterpenoids, triterpenoids, flavonoid compounds, etc. It has a wide range of pharmacological effects, including analgesia, anti-inflammation, antibacterial, immunomodulation, blood vessel dilation, antiplatelet aggregation, improvement of ischemia-reperfusion, etc. It has small toxic and side effects and is widely used clinically.

[0018] Rheum palmatum L. was first recorded in "Shennong Ben Cao Jing". "Rheum palmatum L., with bitter and cold taste, belongs to the stomach, liver and large intestine meridians, and mainly treats stasis under the blood, blood stasis and cold and heat, breaking masses and accumulations." In recent years, a large number of studies have been carried out on the chemical components of Rheum palmatum L. at home and abroad, mainly including anthraquinones, anthrones, stilbenes, phenylbutanones, chromones, flavonoids, tannins, polysaccharides and other components, as well as compounds such as volatile oils, sterols, organic acids and trace elements. It has effects such as anti-inflammation, analgesia, bacteriostasis, and elimination of oxygen free radicals.

[0019] Sophora flavescens Ait. is bitter in taste and cold in nature, and has the effects of clearing heat, drying dampness and killing insects. The chemical components in Sophora flavescens Ait. mainly include alkaloids and flavonoid compounds. The pharmacological effects of flavonoid compounds mainly include anti-inflammation, anti-virus and inhibition of angiogenesis.

[0020] Zanthoxylum bungeanum Maxim. has the effects of warming the middle to stop pain and killing insects and relieving itching. The active substance α-sanshool in Zanthoxylum bungeanum Maxim. has potential analgesic effects on cells. The adenosine diphosphate (ADP), arachidonic acid (AA) and thrombin contained in sanshool have obvious inhibitory effects on platelet aggregation. The polyphenolic compounds of Zanthoxylum bungeanum Maxim. have strong reducing ability and can effectively scavenge active oxygen free radicals. The volatile oil of Zanthoxylum bungeanum Maxim. can inhibit Gram-negative bacteria and Gram-positive bacteria, and at the same time also has an inhibitory effect on molds and fungi, especially the inhibitory effect on Penicillium and Aspergillus niger is the best. The various physiological activities of Zanthoxylum bungeanum Maxim., including anti-inflammation, analgesia, local anesthesia, antioxidant, anti-tumor, bacteriostasis, insecticidal, anti-wrinkle, etc., have broad application prospects in the medical field.

[0021] Artemisia argyi Levl. & Vant. is a commonly used traditional Chinese medicine in China. It is bitter and pungent in taste and warm in nature. It mainly contains volatile oils, flavonoids, phenylpropanoids, terpenoids and other components, and has various pharmacological effects such as antibacterial, antiviral, hemostatic, analgesic, anti-inflammatory, antioxidant, etc.

[0022] Dictamnus dasycarpus Turcz. is bitter and cold in taste, and has the effects of clearing heat and drying dampness, dispelling wind and detoxifying. It has a wide range of pharmacological effects, including anti-inflammation, anti-fungal, anti-atherosclerosis, hemostasis, neuroprotection and antioxidant, etc. It contains a variety of chemical components, including alkaloids, limonoids, flavonoids, sesquiterpenes and their glycosides, steroids, etc. The chemical components of Dictamnus dasycarpus Turcz. are an important material basis for its pharmacological effects.

[0023] Stir-fried Tribulus terrestris has the effects of calming the liver and relieving depression, promoting blood circulation and dispelling wind, resolving phlegm and relieving cough, improving eyesight, promoting urination, and relieving itching. Modern pharmacological studies have shown that it has anti-atherosclerotic and anti-platelet aggregation effects, can inhibit the growth of Staphylococcus aureus, Escherichia coli, etc., showing a certain antibacterial effect, enhancing the body's immunity, and improving the body's ability to scavenge oxygen free radicals.

[0024] This application innovatively combines cinnamon twig, white peony root, rhubarb, sophora flavescens, Sichuan pepper, mugwort leaf, dictamnus root bark, and stir-fried tribulus terrestris in a traditional Chinese medicine preparation. By adjusting the proportions of each ingredient, the aforementioned scar-softening powder is prepared. This combination of different Chinese herbal properties to inhibit scar hyperplasia enhances its effectiveness in scar repair; it also acts before scar formation, perfectly aligning with the dynamic treatment strategy for scar prevention and treatment. This traditional Chinese medicine scar-softening powder is not only suitable for the prevention and treatment of existing scars but also for the early treatment of various surgical and traumatic scars. In the context of scar treatment, a medium- to long-term, chronic process, this traditional Chinese medicine scar-softening powder, due to its simplicity, convenience, and effectiveness, will become an important means of scar repair, greatly advancing the dynamic, long-term, and chronic treatment rhythm of scars.

[0025] The herbal scar softening liquid described in this application has significant advantages in both innovation and efficacy. It can be widely used in the repair of postoperative hypertrophic scars in departments such as burn surgery, plastic surgery, and general surgery, as well as for the treatment of keloids. The aforementioned scar softening liquid can clear heat and promote diuresis, and its external application helps to moisturize and cleanse the scar, thereby contributing to the overall improvement of the scar condition. It also reduces the scar area and lightens the color, thus playing a therapeutic role. It can also be used in conjunction with other scar treatment methods to enhance the therapeutic effect. In addition, it can reduce scar formation and inhibit scar hyperplasia in newly healed wounds, promoting tissue recovery.

[0026] The scar softening liquid of this application embodiment is made from traditional Chinese medicine ingredients. It can be applied externally, thus using traditional Chinese medicine external treatment to improve scar hyperplasia. When applied externally, the traditional Chinese medicine can penetrate deep into the scar tissue to inhibit scar hyperplasia, thereby promoting scar softening and dissipation, effectively treating and inhibiting the occurrence and development of scars. The above-mentioned scar softening liquid is non-toxic, non-irritating, gentle on the skin, yellowish-brown in color, with moderate viscosity, and leaves no residue after wiping.

[0027] The scar softening solution of this application requires the use of gauze. Specifically, a scar patch is made by soaking a double layer of medical degreased gauze with the scar softening solution and applying it to the scar area, at a rate of 20mL / 100cm. 2 Apply externally twice daily for 30 minutes each time.

[0028] The specific instructions for using the above scar patches are as follows:

[0029] First, an allergy test should be performed. Apply the product to an easily observable area of ​​skin (e.g., the inside of the wrist) for 5 minutes and observe for any allergic reactions. If mild local allergic reactions such as redness, swelling, or itching occur, discontinue use immediately. If severe allergic reactions such as widespread rashes or difficulty breathing occur, seek medical attention promptly. For milder symptoms, desensitization therapy with progressive application can be considered. The procedure is as follows: each course of treatment lasts 15 days, once daily. The initial application time is 5 minutes, increasing by 2 minutes each time. If local discomfort occurs, the application time should not be extended accordingly. The maximum area that the scar softening liquid can be used depends on the extent of the scar, and it is recommended that each packet of medication be used for no more than 7 days.

[0030] Besides topical scar creams, existing scar patches and gels on the market generally have limited effectiveness in removing scars. Silicone gels are prone to residue buildup, have poor breathability, and can easily damage the newly formed epithelium and surrounding skin during removal, causing pain and lacking comfort. Furthermore, the small dosage per tube makes them costly for patients with larger scar areas. Improving scars through cosmetic surgery, medication, and laser treatment carries risks and is expensive, potentially adding psychological burdens to patients.

[0031] This application utilizes the advantages of traditional Chinese medicine to address the symptoms often associated with scar patients, such as itching, pain, stickiness, and stagnation in the skin at the scar site after injury. The formula combines various traditional Chinese medicines to create a dispersing liquid that has the effects of clearing heat and dampness, softening and dispersing nodules, resulting in better scar repair.

[0032] Advantages of using topical Chinese herbal medicine to treat scars: Scar patients often suffer from itching, pain, and stickiness due to damp heat accumulating on the skin and scar after injury. This dampness can also affect the joints, making it difficult to flex and extend the joints. Topical treatment on the skin is more effective, and the treatment should focus on clearing heat and removing dampness. The combination of the medicinal properties of the components in the above-mentioned raw materials helps to soften and dissipate scars, lighten pigmentation, and reduce itching and pain.

[0033] A second aspect of this application also provides a method for preparing the above-mentioned scar dissipation liquid, comprising the following steps: weighing each component of the raw materials according to the weight ratio, placing them in a container and soaking them in water, and then decocting them to obtain the scar softening liquid.

[0034] The above preparation method involves processing at room temperature, ensuring that the active ingredients are not destroyed; it is also low-cost, economical, uses mature equipment, and has a simple process; it results in high drug loading, accurate dosage, balanced blood drug concentration, and no peak-valley phenomenon. The embodiments of this application use green raw materials, require no organic solvents in industrial production, cause no environmental pollution, are environmentally friendly, and are suitable for large-scale promotion.

[0035] The present application will be further illustrated by specific embodiments below. All reagents used in the following embodiments are commercially available.

[0036] Example 1

[0037] The scar softening liquid contains the following components by weight: 18 parts cinnamon twig, 18 parts white peony root, 18 parts rhubarb, 36 parts sophora flavescens, 36 parts Sichuan pepper, 36 parts mugwort leaf, 12 parts dictamnus dasycarpus root bark, and 12 parts stir-fried tribulus terrestris.

[0038] The preparation method of the above-mentioned scar softening liquid includes the following steps:

[0039] 1. Take one dose according to the following weight ratio: 18 parts cinnamon twig, 18 parts white peony root, 18 parts rhubarb, 36 parts sophora flavescens, 36 parts Sichuan pepper, 36 parts mugwort leaf, 12 parts dictamnus dasycarpus bark, and 12 parts stir-fried tribulus terrestris.

[0040] 2. Place the Chinese herbal ingredients from step 1 into a clay pot, or use an automatic decoction machine. Soak the herbs in water for about 20 minutes. You can use tap water, well water, or spring water. The amount of water should be 5cm above the surface of the herbs.

[0041] 3. Decoction of the soaked medicinal liquid from step 2, decocting 3 times. First, bring to a boil over high heat, then simmer over low heat for 30 minutes and cool to obtain 600mL of medicinal liquid.

[0042] 4. Use a packaging machine to dispense the cooled drug solution from step 3 into 200mL medical sealed bags, then transfer them to a sterilization room for sterilization under ultraviolet irradiation for 30 minutes, and store at room temperature.

[0043] Example 2

[0044] The scar softening liquid contains the following components by weight: 36 parts cinnamon twig, 36 parts white peony root, 36 parts rhubarb, 72 parts sophora flavescens, 72 parts Sichuan pepper, 72 parts mugwort leaf, 24 parts dictamnus dasycarpus root bark, and 24 parts stir-fried tribulus terrestris.

[0045] The preparation method of the scar softening liquid in this embodiment is the same as that in Example 1, except that the weight parts of each component are different.

[0046] Example 3

[0047] The scar softening liquid contains the following components by weight: 27 parts cinnamon twig, 27 parts white peony root, 27 parts rhubarb, 54 parts sophora flavescens, 54 parts Sichuan pepper, 54 parts mugwort leaf, 18 parts dictamnus dasycarpus root bark, and 18 parts stir-fried tribulus terrestris.

[0048] The preparation method of the scar softening liquid in this embodiment is the same as that in Example 1, except that the weight parts of each component are different.

[0049] Clinical trials were conducted using the scar softening liquids from Examples 1 to 3, as follows:

[0050] Typical Case 1:

[0051] Ms. Wang, a 22-year-old woman from Dengzhou, Nanyang, Henan Province, suffered burns from liquefied gas at home more than three months ago. She developed hard scars on her face and neck, with significant congestion. The largest scar measured approximately 4.5 x 5 cm and protruded 0.1–0.3 cm above the skin. She was diagnosed with facial traumatic hypertrophic scarring with ulceration. She was treated with the scar softening powder from Example 1 applied topically for 20 minutes daily. After three days, the scars softened, the texture became gentler, and the congestion significantly improved. She continued treatment for two more weeks, achieving near-complete recovery. She continued topical application after discharge. A follow-up visit six months later showed no scarring or functional impairment, although slight pigmentation was visible at the scar site.

[0052] Typical Case 2:

[0053] Mr. Zhang, male, 25 years old, from Nanyang City, Henan Province, was admitted to the hospital due to bleeding for 3 hours after a forehead injury. He underwent facial skin debridement and was discharged one week later after healing. One month later, seeking further scar prevention treatment, he came to our hospital. A scar approximately 5cm long was visible on his forehead, with a hard texture, protruding 0.1-0.3cm above the skin, showing significant congestion, but not adherent to local tissue. After applying the scar softening liquid of Example 2 externally for one week, the redness and swelling of the surface skin subsided. Continued external application of this preparation resulted in near-complete healing after 3 weeks, with no obvious scarring and only slight pigmentation. He continued external application of this preparation after discharge. One month later, a follow-up phone call revealed no visible scarring or pigmentation on the local surface.

[0054] Typical Case 3:

[0055] Chen, a 12-year-old male from Zhengzhou, Henan Province, suffered a burn from a machine accident more than six months ago. He developed hard scars on his right hand and wrist, with significant congestion. The largest scar on his hand was approximately 4.5 x 3 cm, protruding 0.1–0.2 cm above the skin. He was diagnosed with hypertrophic scarring with ulceration following hand trauma. The scar softening powder from Example 3 was applied topically for 20 minutes daily. After two days, the scars softened, the texture became gentler, and the congestion improved. Treatment continued for three weeks, resulting in near-complete recovery. There were no visible scars or functional impairments, only slight pigmentation at the scar site.

[0056] Based on the above typical cases, the external application of the scar softening liquid of this application embodiment has a better effect on scar repair.

[0057] Based on years of clinical statistics of the scar softening liquid applied in this application, a total of 120 patients were included, including 70 males and 50 females, with an average age of 30 years. The statistics of scars and acne marks on the affected areas are shown in Table 1; the results of self-reported usage are shown in Table 2.

[0058] Table 1. Clinical statistics of the scar softening solution applied in this application.

[0059]

[0060] Table 2. Case's Self-Perceived Usage Status

[0061]

[0062] Clinical trials have proven that the scar softening liquid of this application has an effectiveness rate of 90% and a cure rate of 87% in removing scars. This is 60% higher in effectiveness and 77% higher in cure rate than other topical solutions; and 45% higher in effectiveness and 67% higher in cure rate than other topical ointments. Using this scar softening liquid can soften and disperse nodules, promote blood circulation and remove blood stasis, clear heat and nourish yin, treating hypertrophic scars, keloids, and atrophic scars left after burns and scalds, keloids left after surgery, post-burn scars, scars left after trauma, and acne scars. It can also accelerate skin metabolism, effectively remove acne scars, and make the skin smooth and bright. It has good efficacy, fast results, an effectiveness rate of over 90%, and a comprehensive treatment effect, achieving the goal of preventing recurrence after healing.

[0063] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A scar softening liquid, characterized in that, Its active pharmaceutical ingredient consists of the following components in parts by weight: Cinnamon twig 18-36 parts, white peony root 18-36 parts, rhubarb 18-36 parts, sophora flavescens 36-72 parts, Sichuan pepper 36-72 parts, mugwort leaf 36-72 parts, dictamnus root bark 12-24 parts, stir-fried tribulus terrestris 12-24 parts.

2. The scar softening liquid according to claim 1, characterized in that, Its raw materials are the following components by weight: 27 parts cinnamon twig, 27 parts white peony root, 27 parts rhubarb, 54 parts sophora flavescens, 54 parts Sichuan pepper, 54 parts mugwort leaf, 18 parts dictamnus dasycarpus root bark, and 18 parts stir-fried tribulus terrestris.

3. The method for preparing the scar softening liquid according to claim 1 or 2, characterized in that, Includes the following steps: Weigh each component of the raw material according to the specified weight ratio, place them in a container and soak them in water, then decoct them to obtain the scar softening liquid.

4. The method for preparing scar softening liquid according to claim 3, characterized in that, In the step of soaking in water, the soaking time is 15 min to 25 min, and the water volume is 5 cm to 10 cm higher than the raw material.

5. The scar softening liquid according to claim 3, characterized in that, In the frying process, the frying is performed 2 to 3 times, and each frying time is 25 to 40 minutes.

6. The scar softening liquid according to claim 3, characterized in that, The steps also include a step of sterilizing with ultraviolet light after the frying step.

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