Slide stepper for pathological tissue individual drop dyeing staining system

By designing a slide stepping drive device, the problem of high throughput required by a standalone HE staining machine was solved, realizing an efficient and automated tissue staining process, improving staining consistency and reducing manufacturing costs.

CN117288547BActive Publication Date: 2025-12-30URIT MEDICAL ELECTRONICS CO LTD
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Patent Information

Application Number
CN202311217877.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-09-20
Publication Date
2025-12-30
Estimated Expiration
2043-09-20

AI Technical Summary

Technical Problem

Existing standalone HE staining machines cannot meet the high-throughput requirements, resulting in inconvenient operation and difficulty in achieving efficient tissue staining.

Method used

The slide stepping transmission device includes a slide flipping mechanism, a staining frame module, left and right front-pushing mechanisms, a lifting mechanism, and a slide lateral displacement mechanism. The stepping structure enables precise positioning and stable transmission of the slide. Combined with the fixed design of the reagent loading module, it realizes the stepping movement of the slide and automated production line operation.

Benefits of technology

It achieves efficient tissue staining, improves staining consistency and high throughput, reduces instrument design size and manufacturing cost, and enables fully automated production line operation.

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Abstract

The present application relates to the technical field of medical apparatus and instruments, in particular to a slide stepping transmission device for a pathological tissue single drop dyeing and staining system, comprising a slide overturning mechanism, a staining frame module, a left front shifting mechanism, a right front shifting mechanism, a lifting mechanism and a slide transverse displacement mechanism; the slide overturning mechanism module comprises an overturning support, an overturning cover, an overturning seat, synchronous wheels, a synchronous belt, a sensor and a rotary motor, the overturning cover is installed on the overturning support through the overturning seat, the overturning seat is rotationally installed on the overturning support, two synchronous wheels are rotationally installed on one side of the overturning seat and the overturning support respectively, the synchronous belt is sleeved on the two synchronous wheels on the two sides respectively, the sensor is installed on one side of the overturning support, the output shaft of the rotary motor is connected with the synchronous wheel, and the rotary motor is fixedly installed on one side of the overturning support, so that precise drop dyeing and staining can be realized, and high positioning accuracy and repeatability can be achieved through the stepping structure.
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Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a slide stepping transmission device for a system for individual staining of pathological tissues. Background Technology

[0002] Hematoxylin and eosin (HE) staining is a commonly used staining method in histological studies to stain tissue sections for observation and analysis of tissue structure and cell morphology. HE staining involves placing the tissue section specimen in a staining chamber and then performing a series of processes including heating, dewaxing, staining, washing, and mounting to ensure uniform and accurate staining. HE staining machines are easy to operate, produce high-resolution staining results, and shorten staining time. Widely used in medical, biological, and pathological diagnostics, it can accommodate tissue sections of different sizes and shapes, reducing manual labor and providing more accurate histological information.

[0003] However, using the above method, the existing standalone HE staining machine cannot meet the high throughput requirements during operation, making it very inconvenient in actual operation. Summary of the Invention

[0004] The purpose of this invention is to provide a slide stepping transmission device for a single-drop staining system for pathological tissues, which can meet the high throughput requirements. This structure maintains stability and reliability under long-term operation and repetitive movement, and can achieve precise drop staining. The stepping structure can achieve high positioning accuracy and repeatability.

[0005] To achieve the above objectives, the present invention provides a slide stepping transmission device for a pathological tissue individual drip staining system, comprising a slide flipping mechanism, a staining frame module, a left front-shifting mechanism, a right front-shifting mechanism, a lifting mechanism, and a slide lateral displacement mechanism.

[0006] The slide flipping mechanism includes: a flipping bracket, a flipping cover, a flipping seat, a synchronous pulley, a synchronous belt, a sensor, and a rotary motor. The flipping cover is mounted on the flipping bracket via the flipping seat. The flipping seat is rotatably mounted on the flipping bracket. The two synchronous pulleys are rotatably mounted on one side of the flipping seat and the flipping bracket, respectively. The synchronous belt is sleeved on both sides of the two synchronous pulleys. The sensor is mounted on one side of the flipping bracket. The output shaft of the rotary motor is connected to the synchronous pulley. The rotary motor is fixedly mounted on one side of the flipping bracket.

[0007] The dyeing frame module includes a water receiving tray, left side plate one, left side plate two, left side plate three, right side plate, partition one, heating plate one, partition two, heating plate two, partition three, heating plate three, partition four, and partition five. The water receiving tray is connected to the flipping bracket. Left side plate one is fixedly installed on one side of the water receiving tray. Left side plate two is fixedly installed on the side of the water receiving tray close to left side plate one. Left side plate three is fixedly installed on the side of the water receiving tray close to left side plate two. Right side plate three is fixedly installed on the side of the water receiving tray away from left side plate one. One side of plate two; the first partition is fixedly installed on one side of the water receiving tray; the first heating plate is fixedly installed on one side of the first partition; the second partition is fixedly installed on one side of the first heating plate; the second heating plate is fixedly installed on one side of the second partition; the third partition is fixedly installed on one side of the second heating plate; the third heating plate is fixedly installed on one side of the third partition; the fourth partition is fixedly installed on one side of the third heating plate; the fourth heating plate is fixedly installed on one side of the fourth partition; the fifth partition is fixedly installed on one side of the fourth heating plate.

[0008] The left-side front derailleur mechanism includes a left-side rotary motor, a left-side motor mounting plate, a left-side synchronous pulley, a left-side synchronous belt, a left-side synchronous belt clamp, a left-side synchronous belt connecting plate, a left-side idler wheel mounting plate, a left-side idler wheel, a left-side sensor, a left-side sensor light-blocking plate, a left-side slider mounting block, a left-side linear guide rail, and a left-side front derailleur lever. The left-side motor mounting plate is fixedly mounted on one side of the left-side plate. The left-side rotary motor is fixedly mounted on one side of the left-side motor mounting plate. The left-side synchronous pulley is connected to the output shaft of the left-side rotary motor. The left-side synchronous belt is connected through the left-side synchronous belt clamp and the left-side synchronous belt connecting plate. The left-side idler wheel mounting plate is fixedly mounted on one side of the left-side plate. The left-side idler wheel is connected to the left-side synchronous pulley through the left-side synchronous belt. The left-side sensor is mounted on one side of the left-side plate. The left-side sensor light-blocking plate is mounted on the side of the left-side plate closer to the left-side sensor.

[0009] The right-side front derailleur mechanism includes a right-side rotary motor, a right-side motor mounting plate, a right-side synchronous pulley, a right-side synchronous belt, a right-side synchronous belt clamp, a right-side synchronous belt connecting plate, a right-side idler wheel mounting plate, a right-side idler wheel, a right-side sensor, a right-side sensor light-blocking plate, a right-side slider mounting block, a right-side linear guide rail, and a right-side front derailleur lever. The right-side motor mounting plate is fixedly mounted on one side of the second right-side plate. The right-side rotary motor is fixedly mounted on one side of the right-side motor mounting plate. The right-side synchronous pulley is connected to the output shaft of the right-side rotary motor. The right-side synchronous belt is connected through the right-side synchronous belt clamp and the right-side synchronous belt connecting plate. The right-side idler wheel mounting plate is fixedly mounted on one side of the second right-side plate. The right-side idler wheel is connected to the right-side synchronous pulley through the right-side synchronous belt. The right-side sensor is mounted on one side of the second right-side plate. The right-side sensor light-blocking plate is mounted on the side of the second right-side plate closer to the right-side sensor.

[0010] The lifting mechanism includes a lifting rotary motor, a lifting motor mounting plate, a base plate, a front bearing mounting plate, a lifting sensor, a coupling, a cam, a rotating shaft, a support bearing, and a rear bearing mounting plate. The lifting motor mounting plate is fixedly connected to the water receiving tray. The lifting rotary motor is fixedly mounted on one side of the lifting motor mounting plate. The base plate is fixedly mounted on one side of the lifting motor mounting plate. The front bearing mounting plate is fixedly mounted on one side of the base plate. The lifting sensor is fixedly mounted on one side of the base plate. The coupling is connected to the output shaft of the rotary motor. The rotating shaft is connected to the coupling. The cam is fixedly mounted on the rotating shaft. The rear bearing mounting plate is mounted on one side of the water receiving tray. The support bearing is connected to the rear bearing mounting plate and sleeved on the rotating shaft.

[0011] The slide lateral displacement mechanism includes four beams: a first beam, a second beam, a third beam, a fourth beam, a round-headed lever pin, lever pin mounting brackets one, two, three, and four, a staining frame support foot, a vertical linear guide rail, a horizontal guide rail mounting plate, a horizontal linear guide rail, a slider mounting block, a right horizontal sensor, an idler wheel, a lower belt connecting plate, an upper belt connecting plate, a transmission belt, a cam bearing, a connecting plate, a tension idler wheel, a displacement rotary motor, a motor mounting plate, a coupling, a transmission synchronous pulley, a transmission shaft support bearing, a bearing mounting plate, a left horizontal sensor, a vertical reset sensor, and a transmission shaft. The round-headed lever pin is installed in the mounting holes of lever pin mounting brackets one, two, three, and four. The first beam, the third beam, the first lever pin, and the fourth lever pin are connected to the first lever pin mounting bracket and the fourth lever pin. Mounting bracket three assembles into a right shift assembly. The second and fourth crossbeams, along with the second and fourth lever pin mounting brackets, assemble into a left shift assembly. The right shift assembly connects to the sliders on both sides of the transverse linear guide rail, and the left shift assembly connects to the two middle sliders of the transverse linear guide rail. The sliders on both sides of the transverse linear guide rail are connected to the lower part of the transmission belt via the lower belt connecting plate, and the middle slider of the transverse linear guide rail is connected to the upper part of the transmission belt via the upper belt connecting plate. The two identical moving structures are synchronously driven by the transmission shaft. The displacement rotary motor is mounted on the motor mounting plate and connected to the bearing mounting plate via the connecting plate. The rotation of the displacement rotary motor drives the transmission shaft to rotate via the coupling. The transmission synchronous pulley is mounted on the rotating transmission shaft, and the transmission synchronous pulley drives the transmission belt to move.

[0012] This invention discloses a slide-stepping transmission device for a pathological tissue individual staining system. Currently, most pathological tissue staining machines on the market use fixed slides. When adding reagents, a sample loading robot moves above the slide to add the sample. Since tissue staining involves multiple steps requiring different reagents to be added at different times, the limited space for the reagent loading robot makes it difficult to install multiple robots. The fixed slide mode also struggles to meet high-throughput requirements. This patent's stepping displacement device allows the reagent loading module to be fixed while the slide moves stepwise. When the slide reaches a predetermined position, the reagent loading module operates. After loading, the slide continues to move stepwise to the next step until all steps are completed. A slide flipping mechanism grips and flips the transported slide, and then a lifting mechanism is provided. The device drives the entire slide lateral displacement mechanism to transport the slides placed on the staining frame module once. Then, it drives the slide lateral displacement mechanism to move down and reset, so as to transport the subsequently reintroduced slides. This completes the step-by-step transmission of the introduced slides. When the slide moves to the end, the corresponding front-pushing mechanism on one side transfers the slide to the other side for back transport. This repeated operation can complete the stable transmission of the slides. The device has a fixed displacement distance and a programmed step time, which ensures consistent staining time and significantly improves staining consistency. At the same time, the staining frame slides adopt a "bow"-shaped step displacement structure, which greatly reduces the size of the instrument and reduces manufacturing costs. This patented device enables the instrument to realize loading and unloading functions more easily, achieving truly fully automated production line operation. Attached Figure Description

[0013] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0014] Figure 1 This is a schematic diagram of the overall structure of the slide stepping transmission device for a pathological tissue individual staining system according to an embodiment of the present invention.

[0015] Figure 2 This is a schematic diagram of the glass slide flipping mechanism according to an embodiment of the present invention.

[0016] Figure 3 This is a schematic diagram of the structure of the coloring frame module in an embodiment of the present invention.

[0017] Figure 4 This is a schematic diagram of the left front derailleur mechanism according to an embodiment of the present invention.

[0018] Figure 5 This is a schematic diagram of the right front derailleur mechanism according to an embodiment of the present invention.

[0019] Figure 6This is a structural schematic diagram of the lifting mechanism according to an embodiment of the present invention.

[0020] Figure 7 This is a schematic diagram of the glass slide lateral displacement mechanism according to an embodiment of the present invention.

[0021] In the diagram: 1-Slide flipping mechanism, 2-Staining frame module, 3-Left front-pushing mechanism, 4-Right front-pushing mechanism, 5-Lifting mechanism, 6-Slide lateral displacement mechanism, 101-Flipping bracket, 102-Flipping cover, 103-Flipping seat, 104-Synchronous pulley, 105-Synchronous belt, 106-Sensor, 107-Rotary motor, 201-Water receiving tray, 202-Left side plate 1, 203-Left side plate 2, 204-Left side plate 3, 205-Right side plate, 206-Partition 1, 207-Heating plate 1, 208-Partition 2, 209-Heating plate 2, 210-Partition 3, 211-Heating plate 3, 212-Partition 4, 213-Heating plate 4, 214-Partition 5 301-Left-side rotary motor, 302-Left-side motor mounting plate, 303-Left-side synchronous pulley, 304-Left-side synchronous belt, 305-Left-side synchronous belt clamp, 306-Left-side synchronous belt connecting plate, 307-Left-side idler wheel mounting plate, 308-Left-side idler wheel, 309-Left-side sensor, 310-Left-side sensor light shield, 311-Left-side slider mounting block, 312-Left-side linear guide rail, 313-Left-side front lever, 401-Right-side rotary motor, 402-Right-side motor mounting plate, 403-Right-side synchronous pulley, 404-Right-side synchronous belt, 405-Right-side synchronous belt clamp, 406-Right-side synchronous belt connecting plate, 407-Right-side idler wheel mounting plate, 408-Right-side Idler wheel, 409-Right side sensor, 410-Right side sensor light shield, 411-Right side slider mounting block, 412-Right side linear guide rail, 413-Right side front lever, 501-Lifting rotary motor, 502-Lifting motor mounting plate, 503-Base plate, 504-Front bearing mounting plate, 505-Lifting sensor, 506-Coupling, 507-Cam, 508-Rotating shaft, 509-Support bearing, 510-Rear bearing mounting plate, 601-Crossbeam 1, 602-Crossbeam 2, 603-Crossbeam 3, 604-Crossbeam 4, 605-Round head lever pin, 606-Lever pin mounting bracket 1, 607-Lever pin mounting bracket 2, 608-Lever pin mounting bracket 3 609-Lever pin mounting bracket 4, 610-Coloring frame support foot, 611-Vertical linear guide rail, 612-Horizontal guide rail mounting plate, 613-Horizontal linear guide rail, 614-Slider mounting block, 615-Horizontal right sensor, 616-Idler wheel, 617-Lower belt connecting plate, 618-Upper belt connecting plate, 619-Transmission belt, 620-Cam bearing, 621-Connecting plate, 622-Tension idler wheel, 623-Displacement rotary motor, 624-Motor mounting plate, 625-Coupling, 626-Transmission synchronous pulley, 627-Transmission shaft support bearing, 628-Bearing mounting plate, 629-Horizontal left sensor, 630-Vertical reset sensor, 631-Transmission shaft. Detailed Implementation

[0022] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0023] The embodiments of this application are as follows:

[0024] Please see Figures 1 to 7 ,in Figure 1 This is a schematic diagram of the overall structure of the slide step-drive device used in a separate staining system for pathological tissues. Figure 2 This is a schematic diagram of the slide flipping mechanism 1. Figure 3 This is a structural diagram of coloring frame module 2. Figure 4 This is a schematic diagram of the left front derailleur mechanism 3. Figure 5 This is a schematic diagram of the right-side front derailleur mechanism 4. Figure 6 This is a structural diagram of the lifting mechanism 5. Figure 7 This is a schematic diagram of the glass slide lateral displacement mechanism 6.

[0025] This invention provides a slide stepping transmission device for a single-drop staining system for pathological tissues: It includes a slide flipping mechanism 1, a staining frame module 2, a left forward-shifting mechanism 3, a right forward-shifting mechanism 4, a lifting mechanism 5, and a slide lateral displacement mechanism 6. The slide flipping mechanism 1 module includes a flipping bracket 101, a flipping cover 102, a flipping seat 103, a synchronous pulley 104, a synchronous belt 105, a sensor 106, and a rotary motor 107. The staining frame module 2 includes a water receiving tray 201, a left side plate 1 202, a left side plate 2 203, a left side plate 3 204, a right side plate 205, a partition 1 206, a heating plate 1 207, a partition 2 208, a heating plate 209, a partition 3 210, and a heating... Plate 3 211, partition 4 212, heating plate 4 213, and partition 5 214; the left front derailleur mechanism 3 includes a left rotary motor 301, a left motor mounting plate 302, a left synchronous pulley 303, a left synchronous belt 304, a left synchronous belt clamping plate 305, a left synchronous belt connecting plate 306, a left idler wheel mounting plate 307, a left idler wheel 308, a left sensor 309, a left sensor light-blocking plate 310, a left slider mounting block 311, a left linear guide rail 312, and a left front derailleur lever 313; the right front derailleur mechanism 4 includes a right rotary motor 401, a right motor mounting plate 402, a right synchronous pulley 403, a right synchronous belt 404, a right synchronous belt clamping plate 405, and a right... The system includes a synchronous belt connecting plate 406, a right idler wheel mounting plate 407, a right idler wheel 408, a right sensor 409, a right sensor light-blocking plate 410, a right slider mounting block 411, a right linear guide rail 412, and a right front lever 413. The lifting mechanism 5 includes a lifting rotary motor 501, a lifting motor mounting plate 502, a base plate 503, a front bearing mounting plate 504, a lifting sensor 505, a coupling 506, a cam 507, a rotating shaft 508, a support bearing 509, and a rear bearing mounting plate 510. The glass slide lateral displacement mechanism 6 includes a first crossbeam 602, a second crossbeam 601, a third crossbeam 603, a fourth crossbeam 604, a round-headed lever pin 605, and a lever pin mounting bracket 601. 6. Lever pin mounting bracket 2 607, Lever pin mounting bracket 3 608, Lever pin mounting bracket 4 609, Coloring frame support foot 610, Vertical linear guide rail 611, Horizontal guide rail mounting plate 612, Horizontal linear guide rail 613, Slider mounting block 614, Horizontal right sensor 615, Idler wheel 616, Lower belt connecting plate 617, Upper belt connecting plate 618, Transmission belt 619, Cam bearing 620, Connecting plate 621, Tensioning idler wheel 622, Displacement rotary motor 623, Motor mounting plate 624, Coupling 625, Transmission synchronous pulley 626, Transmission shaft support bearing 627, Bearing mounting plate 628, Horizontal left sensor 629, Vertical reset sensor 630, and Transmission shaft 631.

[0026] In this specific embodiment, the flip cover 102 is mounted on the flip bracket 101 via the flip seat 103. The flip seat 103 is rotatably mounted on the flip bracket 101. Two synchronous pulleys 104 are rotatably mounted on one side of the flip seat 103 and the flip bracket 101, respectively. The synchronous belt 105 is respectively sleeved on both sides of the two synchronous pulleys 104. The sensor 106 is mounted on one side of the flip bracket 101. The output shaft of the rotary motor 107 is connected to the synchronous pulleys 104. The rotary motor 107 is fixedly mounted on one side of the flip bracket 101. In the slide flipping mechanism 1, the flipping cover 102 is installed on the flipping seat 103, the flipping seat 103 and the corresponding flipping rotation shaft and bearing provided on the flipping seat 103 are installed in the flipping bracket 101, the exposed end of the flipping rotation shaft is installed with the synchronous wheel 104, the rotary motor 107 is installed on the flipping bracket 101, the motor shaft end is installed with the synchronous wheel 104, the two synchronous wheels 104 are connected by the synchronous belt 105, the motor rotation drives the shaft to rotate through the synchronous belt 105, realizing the horizontal and vertical placement of the slide, and the status position is detected by the sensor 106.

[0027] The dyeing frame module 2 includes a water receiving tray 201, a left side plate 202, a left side plate 203, a left side plate 204, a right side plate 205, a partition 206, a heating plate 207, a partition 208, a heating plate 209, a partition 210, a heating plate 211, a partition 212, a heating plate 213, and a partition 214. The water receiving tray 201 is connected to the flipping bracket 101. The left side plate 202 is fixedly installed on one side of the water receiving tray 201. The left side plate 203 is fixedly installed on the side of the water receiving tray 201 near the left side plate 202. The left side plate 204 is fixedly installed on the side of the water receiving tray 201 near the left side plate 202. The first partition plate 206 is fixedly installed on one side of the water receiving tray 201, close to the left side plate 203; the second partition plate 208 is fixedly installed on one side of the heating plate 207; the third partition plate 209 is fixedly installed on one side of the partition plate 208; the fourth partition plate 210 is fixedly installed on one side of the heating plate 209; and the fifth partition plate 211 is fixedly installed on the third partition plate 208. 210 is located on one side; the partition four 212 is fixedly installed on one side of the heating plate three 211; the heating plate four 213 is fixedly installed on one side of the partition four 212; the partition five 214 is fixedly installed on one side of the heating plate four 213. In the dyeing frame module 2, the left side plate three 204, the right side plate 205, the partition one 206, the heating plate one 207, and the partition two 208 are installed together to form a first row of displacement channels. The left side plate two 203, the heating plate two 209, the partition three 210, the heating plate three 211, and the partition four 212 are sequentially installed in the first row of channels. The second and third rows of displacement channels are formed in front of the first row. The left side plate 202, the heating plate 213, and the partition 214 are installed in front of the third row of channels to form the fourth row of displacement channels. The partition and the side plate form an integral frame, which can restrict the back-and-forth movement of the glass slide during the displacement process. The glass slide is placed on the heating plate, which is equipped with heating elements. The glass slide is heated by setting a program. When the glass slide moves to the last position of each row of displacement channels, it can enter the next row of channels to achieve "bow" shaped displacement. The water receiving tray 201 is installed under the dyeing frame and its function is to collect various liquid waste liquids during the dyeing process and collect them into the corresponding containers through pipelines.

[0028] Secondly, the left front derailleur mechanism 3 includes a left rotary motor 301, a left motor mounting plate 302, a left synchronous pulley 303, a left synchronous belt 304, a left synchronous belt clamping plate 305, a left synchronous belt connecting plate 306, a left idler wheel mounting plate 307, a left idler wheel 308, a left sensor 309, a left sensor light-blocking plate 310, a left slider mounting block 311, a left linear guide rail 312, and a left front derailleur lever 313; the left motor mounting plate 302 is fixedly mounted on one side of the left plate 203; the left rotary motor 301 is fixedly mounted on the left motor mounting plate 302. The left synchronous pulley 303 is connected to the output shaft of the left rotary motor 301; the left synchronous belt 304 is connected to the left synchronous belt clamp 305 and the left synchronous belt connecting plate 306; the left idler wheel mounting plate 307 is fixedly installed on one side of the left plate 203; the left idler wheel 308 is connected to the left synchronous pulley 303 via the left synchronous belt 304; the left sensor 309 is installed on one side of the left plate 203; the left sensor light-blocking plate 310 is installed on the left plate 203 near the left sensor 309. On the right side, the right front derailleur mechanism 4 includes a right rotary motor 401, a right motor mounting plate 402, a right synchronous pulley 403, a right synchronous belt 404, a right synchronous belt clamping plate 405, a right synchronous belt connecting plate 406, a right idler wheel mounting plate 407, a right idler wheel 408, a right sensor 409, a right sensor light-blocking plate 410, a right slider mounting block 411, a right linear guide rail 412, and a right front derailleur lever 413; the right motor mounting plate 402 is fixedly mounted on one side of the right plate 205; the right rotary motor 401 is fixedly mounted on the right motor mounting plate 402. On one side; the right synchronous pulley 403 is connected to the output shaft of the right rotary motor 401; the right synchronous belt 404 is connected through the right synchronous belt clamp 405 and the right synchronous belt connecting plate 406; the right idler wheel mounting plate 407 is fixedly installed on one side of the second right side plate 205; the right idler wheel 408 is connected to the right synchronous pulley 403 through the right synchronous belt 404; the right sensor 409 is installed on one side of the second right side plate 205; the right sensor light-blocking plate 410 is installed on the side of the second right side plate 205 near the right sensor 409;The motor mounting plates of the left front derailleur mechanism 3 and the right front derailleur mechanism 4 are respectively fixed to the side plates of the staining frame on their respective sides. Simultaneously, the corresponding motors are mounted on their respective mounting plates, and the corresponding synchronous pulleys are mounted on the shafts of the corresponding motors. The corresponding synchronous pulleys are connected to the corresponding idler pulleys via corresponding synchronous belts. The corresponding idler pulleys are mounted on the corresponding idler pulley mounting plates, which are then fixed to the side plates of the staining frame on their respective sides. The corresponding synchronous belt is connected to the corresponding synchronous belt connecting plate via a corresponding synchronous belt clamp. The corresponding synchronous belt connecting plate and the corresponding front derailleur are fixed to the corresponding slider mounting block. The corresponding slider mounting block is mounted on the corresponding linear guide slider. The corresponding linear guide slide is mounted on the side plate of the staining frame. The rotation of the corresponding motor drives the corresponding synchronous belt to rotate via the synchronous pulley on its corresponding side. The rotation of the corresponding synchronous belt connecting plate drives the corresponding slider mounting block, the corresponding linear guide slider, and the corresponding front derailleur to move, and the corresponding front derailleur pushes the glass slide forward.

[0029] Meanwhile, the lifting mechanism 5 includes a lifting rotary motor 501, a lifting motor mounting plate 502, a base plate 503, a front bearing mounting plate 504, a lifting sensor 505, a coupling 506, a cam 507, a rotating shaft 508, a support bearing 509, and a rear bearing mounting plate 510. The lifting motor mounting plate 502 is fixedly connected to the water receiving tray 201; the lifting rotary motor 501 is fixedly mounted on one side of the lifting motor mounting plate 502; the base plate 503 is fixedly mounted on one side of the lifting motor mounting plate 502; the front bearing mounting plate 504 is fixedly mounted on one side of the base plate 503; the lifting sensor 505 is fixedly mounted on one side of the base plate 503; the coupling 506 is connected to the output shaft of the rotary motor 107; and the rotating shaft 508 is connected to the coupling 506. The connection is as follows: the cam 507 is fixedly mounted on the rotating shaft 508; the rear bearing mounting plate 510 is mounted on one side of the water receiving tray 201; the support bearing 509 is connected to the rear bearing mounting plate 510 and sleeved on the rotating shaft 508; the lifting mechanism 5 fixes the lifting rotary motor 501 on the lifting motor mounting plate 502 and the front bearing mounting plate 504 through the base plate 503; the shaft end of the lifting rotary motor 501 is connected to the coupling 506, and the other end of the coupling 506 is connected to the rotating shaft 508; the cam 507 is fixed on the rotating shaft 508; the rotary motor 107 rotates and drives the rotating shaft 508 to rotate through the coupling 506, while simultaneously driving the cam 507 to move; the lifting sensor 505 plays a reset role.

[0030] Finally, the slide lateral displacement mechanism 6 includes a first crossbeam 602, a second crossbeam 601, a third crossbeam 603, a fourth crossbeam 604, a round-headed lever pin 605, a lever pin mounting bracket 1 606, a lever pin mounting bracket 2 607, a lever pin mounting bracket 3 608, a lever pin mounting bracket 4 609, a staining frame support foot 610, a vertical linear guide rail 611, a lateral guide rail mounting plate 612, a lateral linear guide rail 613, a slider mounting block 614, a lateral right sensor 615, an idler wheel 616, a lower belt connecting plate 617, an upper belt connecting plate 618, a transmission belt 619, a cam bearing 620, a connecting plate 621, a tension idler wheel 622, a displacement rotary motor 623, a motor mounting plate 624, a coupling 625, and a transmission synchronous pulley 62. 6. The drive shaft supports bearing 627, bearing mounting plate 628, lateral left sensor 629, vertical reset sensor 630, and drive shaft 631. The round-headed lever pin 605 is installed in the mounting holes of lever pin mounting bracket one 606, lever pin mounting bracket two 607, lever pin mounting bracket three 608, and lever pin mounting bracket four 609. The crossbeam one 602 and the crossbeam three 603 are assembled with lever pin mounting bracket one 606 and lever pin mounting bracket three 608 to form a right lever assembly. The crossbeam two 601 and the crossbeam four 604 are assembled with lever pin mounting bracket two 607 and lever pin mounting bracket four 609 to form a left lever assembly. The right lever assembly is connected to the lateral linear guide rail 613. The two side sliders are connected, and the left-hand shifting assembly is connected to the two middle sliders of the transverse linear guide 613. The two side sliders of the transverse linear guide 613 are connected to the lower part of the transmission belt 619 through the lower belt connecting plate 617, and the middle slider of the transverse linear guide 613 is connected to the upper part of the transmission belt 619 through the upper belt connecting plate 618. The two sets of identical moving structures are synchronously driven by the transmission shaft 631. The displacement rotary motor 623 is mounted on the motor mounting plate and connected to the bearing mounting plate through the connecting plate. The rotation of the displacement rotary motor 623 drives the transmission shaft 631 to rotate through the coupling 625. The transmission synchronous pulley 626 is mounted on the rotating transmission shaft 631. Wheel 626 drives the transmission belt 619 to move. In the transverse displacement mechanism 6 of the glass slide, the round-headed lever pin 605 is installed in the mounting holes of lever pin mounting bracket one 606, lever pin mounting bracket two 607, lever pin mounting bracket three 608, and lever pin mounting bracket four 609. The distance between the two pins is the width of the glass slide plus a corresponding gap. The crossbeam one 602 and crossbeam three 603 are assembled with lever pin mounting bracket one 606 and lever pin mounting bracket three 608 to form a right-hand shift assembly. The crossbeam two 601 and crossbeam four 604 are assembled with lever pin mounting bracket two 607 and lever pin mounting bracket four 609 to form a left-hand shift assembly. The right-hand shift assembly is connected to the sliders on both sides of the transverse linear guide rail 613.The left-hand shift assembly is connected to the two middle sliders of the transverse linear guide 613. The sliders on both sides of the transverse linear guide 613 are connected to the lower part of the transmission belt 619 through the lower belt connecting plate 617. The middle slider of the transverse linear guide 613 is connected to the upper part of the transmission belt 619 through the upper belt connecting plate 618. The two sets of identical moving structures are synchronously driven by the transmission shaft 631. The displacement rotary motor 623 is mounted on the motor mounting plate and connected to the bearing mounting plate through the connecting plate. The displacement rotary motor 623 rotates through the coupling 625. The drive shaft 631 rotates, and the drive synchronous pulley 626 is mounted on the rotating drive shaft 631. The drive synchronous pulley 626 drives the drive belt 619 to move. At this time, the slider mounted on the lower part of the drive belt 619 and the slider mounted on the upper part of the drive belt 619 form a "split" displacement movement. The right shift assembly and the left shift assembly mounted on the slider also form a "split" movement. The glass slide lateral displacement mechanism 6 achieves overall up and down movement through the vertical linear guide rail 611 and the cam bearing 620 in conjunction with the cam 507 of the lifting mechanism 5.

[0031] In this embodiment, a slide stepping transmission device for a pathological tissue individual staining system is used. Because most pathological tissue staining machines on the market have fixed slides, requiring a sample loading robot to move above the slide to add reagents, and because tissue staining involves multiple steps requiring different reagents at different times, the limited space for the reagent loading robot makes it difficult to install multiple robots. The fixed slide mode also struggles to meet high-throughput requirements. This patent's stepping displacement device fixes the reagent loading module while the slide moves stepwise. When the slide reaches a predetermined position, the reagent loading module operates, and after loading, the slide continues to step forward to the next step until all steps are completed. The slide flipping mechanism 1, which holds the transported slide, is then used by the robot to grip it. The slide is clamped and flipped, and then the entire slide lateral displacement mechanism 6 is driven by the lifting mechanism 5 to transport the slide placed on the staining frame module 2. After that, the slide lateral displacement mechanism 6 is driven to move down and reset, so as to transport the subsequently reintroduced slides. This completes the step-by-step transmission of the introduced slides. When the slide moves to the end, the front deflector mechanism on the corresponding side transfers the slide to the other side for back transport. This repeated operation can complete the stable transmission of the slides. The displacement distance of this device is fixed and the step time is programmed, so the staining time is consistent and the staining consistency is significantly improved. At the same time, the staining frame slide adopts a "bow"-shaped step displacement structure, which greatly reduces the design size of the instrument and reduces manufacturing costs. This patented device can make the instrument realize the loading and unloading function more simply and realize a truly fully automated production line operation.

[0032] The above-disclosed embodiments are merely one or more preferred embodiments of this application and should not be construed as limiting the scope of this application. Those skilled in the art can understand that all or part of the processes for implementing the above embodiments and equivalent changes made in accordance with the claims of this application still fall within the scope of this application.

Claims

1. A slide stepping drive device for pathological tissue single drop dyeing staining system, characterized in that, It comprises a slide turnover mechanism, a staining frame module, a left front dial mechanism, a right front dial mechanism, a lifting mechanism and a slide transverse displacement mechanism; The slide turnover mechanism comprises a turnover support, a turnover cover, a turnover seat, synchronous wheels, a synchronous belt, a sensor and a rotary motor, the turnover cover is installed on the turnover support through the turnover seat, the turnover seat is rotationally installed on the turnover support, two synchronous wheels are rotationally installed on one side of the turnover seat and the turnover support respectively, the synchronous belt is sleeved on the two synchronous wheels respectively, the sensor is installed on one side of the turnover support, and the output shaft of the rotary motor is connected with the synchronous wheel, and the rotary motor is fixedly installed on one side of the turnover support; The staining frame module comprises a water pan, a left side plate one, a left side plate two, a left side plate three, a right side plate, a partition one, a heating plate one, a partition two, a heating plate two, a partition three, a heating plate three, a partition four, a heating plate four and a partition five, the water pan is connected with the turnover support, the left side plate one is fixedly installed on one side of the water pan, the left side plate two is fixedly installed on one side of the water pan close to the left side plate one, the left side plate three is fixedly installed on one side of the water pan close to the left side plate two, the right side plate is fixedly installed on one side of the water pan away from the left side plate two, the partition one is fixedly installed on one side of the water pan, the heating plate one is fixedly installed on one side of the partition one, the partition two is fixedly installed on one side of the heating plate one, the heating plate two is fixedly installed on one side of the partition two, the partition three is fixedly installed on one side of the heating plate two, the heating plate three is fixedly installed on one side of the partition three, the partition four is fixedly installed on one side of the heating plate three, the heating plate four is fixedly installed on one side of the partition four, and the partition five is fixedly installed on one side of the heating plate four; The left front dial mechanism comprises a left rotary motor, a left motor mounting plate, a left synchronous wheel, a left synchronous belt, a left synchronous belt clamping plate, a left synchronous belt connecting plate, a left idler mounting plate, a left idler, a left sensor, a left sensor light shield, a left slider mounting block, a left linear guide rail and a left front dial rod, the left motor mounting plate is fixedly installed on one side of the left side plate two, the left rotary motor is fixedly installed on one side of the left motor mounting plate, the left synchronous wheel is connected with the output shaft of the left rotary motor, the left synchronous belt is connected through the left synchronous belt clamping plate and the left synchronous belt connecting plate, the left idler mounting plate is fixedly installed on one side of the left side plate two, the left idler is connected with the left synchronous wheel through the left synchronous belt, the left sensor is installed on one side of the left side plate two, and the left sensor light shield is installed on one side of the left side plate two close to the left sensor. The right front dialing mechanism comprises a right rotating motor, a right motor mounting plate, a right synchronous wheel, a right synchronous belt, a right synchronous belt clamping plate, a right synchronous belt connecting plate, a right idler mounting plate, a right idler, a right sensor, a right sensor light shield, a right slider mounting block, a right linear guide rail and a right front dialing lever; the right motor mounting plate is fixedly installed on one side of the right plate; the right rotating motor is fixedly installed on one side of the right motor mounting plate; the right synchronous wheel is connected with an output shaft of the right rotating motor; the right synchronous belt is connected through the right synchronous belt clamping plate and the right synchronous belt connecting plate; the right idler mounting plate is fixedly installed on one side of the right plate; the right idler is connected with the right synchronous wheel through the right synchronous belt; the right sensor is installed on one side of the right plate; and the right sensor light shield is installed on one side of the right plate close to the right sensor; The lifting mechanism comprises a lifting rotating motor, a lifting motor mounting plate, a bottom plate, a front bearing mounting plate, a lifting sensor, a shaft coupling, a cam, a rotating shaft, a supporting bearing and a rear bearing mounting plate; the lifting motor mounting plate is fixedly connected with the water pan; the lifting rotating motor is fixedly installed on one side of the lifting motor mounting plate; the bottom plate is fixedly installed on one side of the lifting motor mounting plate; the front bearing mounting plate is fixedly installed on one side of the bottom plate; the lifting sensor is fixedly installed on one side of the bottom plate; the shaft coupling is connected with an output shaft of the rotating motor; the rotating shaft is connected with the shaft coupling; the cam is fixedly installed on the rotating shaft; the rear bearing mounting plate is installed on one side of the water pan; and the supporting bearing is connected with the rear bearing mounting plate and is sleeved on the rotating shaft; The slide transverse displacement mechanism comprises a crossbeam one, a crossbeam two, a crossbeam three, a crossbeam four, a round head lever pin, a lever pin mounting frame one, a lever pin mounting frame two, a lever pin mounting frame three, a lever pin mounting frame four, a staining frame support foot, a vertical linear guide rail, a transverse guide rail mounting plate, a transverse linear guide rail, a sliding block mounting block, a transverse right sensor, an idler, a lower belt connecting plate, an upper belt connecting plate, a transmission belt, a cam bearing, a connecting plate, a tension idler, a displacement rotary motor, a motor mounting plate, a coupling, a transmission synchronous wheel, a transmission shaft support bearing, a bearing mounting plate, a transverse left sensor, a vertical reset sensor and a transmission shaft, the round head lever pin is installed in the mounting hole of the lever pin mounting frame one, the lever pin mounting frame two, the lever pin mounting frame three and the lever pin mounting frame four, the crossbeam one, the crossbeam three and the lever pin mounting frame one, the lever pin mounting frame three are assembled to form a right lever assembly, the crossbeam two, the crossbeam four and the lever pin mounting frame two, the lever pin mounting frame four are assembled to form a left lever assembly, the right lever assembly is connected with the two side sliding blocks of the transverse linear guide rail, the left lever assembly is connected with the two middle sliding blocks of the transverse linear guide rail, the two side sliding blocks of the transverse linear guide rail are connected with the lower part of the transmission belt through the lower belt connecting plate, the two middle sliding blocks of the transverse linear guide rail are connected with the upper part of the transmission belt through the upper belt connecting plate, the front and rear two sets of same moving structures are synchronously driven by the transmission shaft, the displacement rotary motor is installed on the motor mounting plate and connected with the bearing mounting plate through the connecting plate, the displacement rotary motor is rotated to drive the transmission shaft to rotate through the coupling, the transmission shaft is installed with the transmission synchronous wheel, and the transmission synchronous wheel drives the transmission belt to move.

Citation Information

Patent Citations

  • Slide stepping drive device for pathological tissue individual drop staining system

    CN221056182U