A drug for repelling or fumigating tobacco beetles and its application

Abstract

The present invention relates to the technical field of tobacco beetle prevention and control. The present invention provides a drug for repelling or fumigating tobacco beetles and its application, wherein the drug comprises methyl benzoate and / or 3-formylbenzoic acid methyl ester. The present invention finds that more than 200 ppm of methyl benzoate, more than 500 ppm of 3-formylbenzoic acid methyl ester, or a composition of the two, can produce a significant repellent effect on tobacco beetles in both a "Y" type olfactometer test and a free choice test. At the same time, methyl benzoate and 3-formylbenzoic acid methyl ester, respectively, at 110 g L ‑1 and 200g L ‑1 The fumigation effect on tobacco beetles at the above concentrations reaches 100%. Methyl benzoate alone, methyl 3-formylbenzoate or a combination of the two can effectively reduce the use of traditional fumigants, is more environmentally friendly, and is of great significance in the prevention and control of tobacco beetles.

Description

Technical Field

[0001] The invention relates to the technical field of tobacco beetle prevention and treatment, and in particular to a medicine for repelling or fumigating tobacco beetles and application thereof. Background Art

[0002] The tobacco beetle (Lasioderma serricorne (Fabricius)) belongs to the family of Coleoptera and is a worldwide tobacco storage pest. It is distributed in most areas of my country, including Taiwan, Zhejiang, Hubei, Hunan, Henan, etc. The beetle likes to eat tobacco leaves aged in warehouses. It can not only enter the inside of cigarettes to eat, but also produce feces that can contaminate tobacco leaves and tobacco products, seriously affecting the use value of tobacco leaves.

[0003] At present, the main means of preventing and controlling tobacco beetles at home and abroad is still chemical fumigation, which is efficient and rapid, so that it can control the occurrence of tobacco beetles in a relatively short time. However, chemical agents such as aluminum phosphide and methyl bromide have been gradually eliminated due to problems such as tobacco beetle resistance and environmental pollution. At present, most domestic companies mainly use phosphine fumigation technology to kill tobacco beetles. However, studies have shown that the large-scale use of phosphine has caused tobacco beetles to begin to develop resistance; in addition, a small amount of phosphine residues on the surface of tobacco leaves will affect its quality. Therefore, the development of new green prevention and control methods for tobacco beetles is of great scientific significance.

[0004] Benzoate esters are a class of secondary metabolites widely found in plants. The main characteristic of this class of compounds is strong volatility, which plays an important role in the interaction between plants and insects. Methyl benzoate was first discovered in flowers and has been widely used as a fragrance in the perfume industry. It has also been approved by the US Food and Drug Administration (FDA) and the European Union as a food-grade safe compound and can be used as a flavoring agent and adjuvant. Methyl benzoate has also been reported to have certain insecticidal activity, and it has a good preventive effect on some leaf-feeding insects and stored grain pests. Methyl salicylate can repel pests on Arabidopsis and soybeans, and can effectively attract natural enemies of pests under natural growth conditions of soybeans and cranberries. Methyl anthranilate is a volatile odor released from many fruits and is related to the flavor of the fruit. Studies have found that spraying methyl anthranilate in grape and corn growing areas can significantly increase the number of parasitic natural enemy insects. In addition, methyl anthranilate synthesized in corn roots has a strong repellent effect on corn root beetle larvae. Therefore, parabens are potential insect attractants and repellents. Summary of the invention

[0005] The purpose of the present invention is to provide a medicine for repelling or fumigating tobacco beetles and its application, so as to reduce the use of traditional fumigants.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a medicine for repelling or fumigating tobacco beetles, and the medicine comprises methyl benzoate and / or methyl 3-formylbenzoate.

[0008] The invention also provides application of the drug in preparing a tobacco beetle repellent.

[0009] Preferably, when the drug is used as a tobacco beetle repellent, the minimum effective concentration of methyl benzoate is 200 ppm, and the minimum effective concentration of methyl 3-formylbenzoate is 500 ppm.

[0010] The invention also provides application of the medicine in preparing tobacco amine fumigant.

[0011] Preferably, the minimum effective concentration of methyl benzoate when the drug is used as a tobacco fumigant is 110 g L -1 The minimum effective concentration of methyl 3-formylbenzoate is 200 g L -1 .

[0012] The present invention provides a drug for repelling or fumigating tobacco beetles and its application, wherein the drug comprises methyl benzoate and / or methyl 3-formylbenzoate. The present invention finds that methyl benzoate alone at more than 200 ppm, methyl 3-formylbenzoate at more than 500 ppm, or a combination of the two can produce a significant repellent effect on tobacco beetles in both a "Y" type olfactometer test and a free choice test. At the same time, methyl benzoate and methyl 3-formylbenzoate can repel tobacco beetles at 110 g L -1 and 200g L -1 The fumigation effect on tobacco beetles at the above concentrations reaches 100%. Methyl benzoate, methyl 3-formylbenzoate or a combination of the two can effectively reduce the use of traditional fumigants, are more environmentally friendly, and are of great significance in the prevention and control of tobacco beetles. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 The effects of methyl benzoate on tobacco beetle at low and high concentrations are shown respectively;

[0014] Figure 2 To screen the minimum effective concentration of methyl benzoate for the repellent effect on tobacco beetles;

[0015] Figure 3 This is a schematic diagram of the free-choice test apparatus for tobacco beetles;

[0016] Figure 4 To investigate the repellent effect of methyl benzoate on Nicotiana tabacum by a free choice test;

[0017] Figure 5The mortality rate of tobacco beetles after 24 hours of fumigation with different concentrations of methyl benzoate;

[0018] Figure 6 The effects of methyl 3-formylbenzoate on tobacco beetle at low and high concentrations are shown respectively;

[0019] Figure 7 To screen the minimum effective concentration of 3-formylbenzoic acid methyl ester for its repellent effect on tobacco beetles;

[0020] Figure 8 To investigate the repellent effect of methyl 3-formylbenzoate on tobacco beetles in a free choice test;

[0021] Fig. 9 The mortality rate of tobacco beetles after 24 hours of fumigation with different concentrations of methyl 3-toluate;

[0022] Fig.10 The effect of 200ppm methyl benzoate and different concentrations of 3-formylbenzoic acid methyl ester on tobacco leaves;

[0023] Fig.11 The aim of this study was to study the repellent effect of a mixture of methyl benzoate and methyl 3-formylbenzoate on tobacco beetles through a free test. DETAILED DESCRIPTION

[0024] The invention provides a medicine for repelling or fumigating tobacco beetles, and the medicine comprises methyl benzoate and / or methyl 3-formylbenzoate.

[0025] The invention also provides application of the drug in preparing a tobacco beetle repellent.

[0026] In the present invention, the minimum effective concentration of methyl benzoate when the drug is used as a tobacco beetle repellent is 200 ppm.

[0027] In the present invention, when the drug is used as a tobacco beetle repellent, the concentration of methyl benzoate is preferably 200 to 4000 ppm.

[0028] In the present invention, when the drug is used as a tobacco beetle repellent, the minimum effective concentration of methyl 3-formylbenzoate is 500 ppm.

[0029] In the present invention, when the drug is used as a tobacco beetle repellent, the concentration of methyl 3-formylbenzoate is preferably 500 to 4000 ppm.

[0030] The invention also provides application of the medicine in preparing tobacco amine fumigant.

[0031] In the present invention, the minimum effective concentration of methyl benzoate when the drug is used as a tobacco fumigant is 110 g / L -1 .

[0032] In the present invention, when the drug is used as a tobacco fumigant, the concentration of methyl benzoate is preferably 110 to 200 g / L -1 .

[0033] In the present invention, the minimum effective concentration of methyl 3-formylbenzoate when the drug is used as a tobacco fumigant is 200 g L -1 .

[0034] In the present invention, when the drug is used as a tobacco fumigant, the concentration of methyl 3-formylbenzoate is preferably 200 to 400 g L -1 .

[0035] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0036] In the following examples, methyl benzoate was purchased from Shanghai MacLean Biochemical Co., Ltd. and prepared into different concentrations using anhydrous ethanol as solvent for use in the "Y" type olfactometer, free choice and fumigation tests.

[0037] Methyl 3-formylbenzoate was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. and prepared into different concentrations using anhydrous ethanol as solvent for use in the “Y” type olfactometer and fumigation tests.

[0038] Example 1 The drug only includes methyl benzoate

[0039] 1. “Y” type olfactometer test

[0040] (1) Different concentrations of methyl benzoate (100 ppm, 200 ppm, 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm) and the solvent anhydrous ethanol were used as odor sources.

[0041] (2) The air was filtered through activated carbon, humidified by passing through a wide-mouth bottle containing distilled water, and then passed through two separate airflow meters (150 mL / min). -1 ), then passed through the odor source, and finally entered the "Y"-shaped olfactometer (stem length 10 cm, two arms 10 cm long and 75°, inner diameter 1.5 cm), and all parts were connected by silicone tubes with a diameter of 0.6 cm.

[0042] (3) Place a single adult tobacco beetle at the base of the stem of a "Y"-shaped olfactometer, and then observe its position for 5 minutes. When the tobacco beetle moves beyond the threshold line in the middle of any arm for at least 10 seconds, it is recorded as having chosen the odor source. Tobacco beetles that did not make a choice during the observation time were recorded as not making a choice, and their data were not included in the statistical analysis. Each tobacco beetle was tested only once, and a total of 40 tobacco beetles were tested for each treatment. All tests were conducted between 9:00 and 18:00 in a climate-controlled laboratory (29±1℃, 70±5%RH). After testing every 10 tobacco beetles, the position of the odor source and its subsequent devices was reversed to avoid positional deviation. After the test, all glassware was washed with anhydrous ethanol and dried in an oven at 60℃.

[0043] (4) Finally, the number of different odor sources selected by tobacco beetles was counted, and the DPS statistical analysis software was used to calculate whether there was a significant difference.

[0044] Test results

[0045] First, we measured the effects of methyl benzoate on tobacco beetles at low concentrations (10 ppm) and high concentrations (4000 ppm). Figure 1 The results showed that methyl benzoate had a significant repellent effect on tobacco beetles at high concentrations, and also showed a certain repellent effect at low concentrations.

[0046] We then determined the minimum effective concentration of methyl benzoate for the repellent effect on tobacco beetles. Figure 2 The results show that the minimum effective concentration of methyl benzoate is 200ppm.

[0047] 2. Free-choice test

[0048] (1) Methyl benzoate at a concentration of 200 ppm and anhydrous ethanol as a solvent were used as odor sources.

[0049] (2) Take 40 tobacco beetles, put them into a clean 250 mL conical bottle, cover with a sealing film, poke small holes in the film, and starve them for 8 hours in a climate-controlled incubator (29±1℃, 70±5%RH) until ready for use in the experiment.

[0050] (3) Weigh 2.5 g of food (a mixture of oatmeal flour and whole wheat flour in a mass ratio of 7:3) and spread it evenly in a plastic culture dish with a diameter of 6 cm. Then, nest a plastic culture dish with a diameter of 9 cm. Wrap two circles of medical tape on the outside of the 9 cm plastic culture dish, and the tape is coated with 0.4 mL of methyl benzoate, forming a food + odor source device.

[0051] (4) During the test, the food + odor source 1 device was placed in a plastic box (length 57 cm, width 57 cm, height 25 cm) at two of the four corners, and the food + odor source 2 device was placed at the other two corners. 40 tobacco beetles were placed at the center of the plastic box and released (e.g. Figure 3 As shown), the plastic box was covered with breathable black cotton cloth to avoid the influence of light. After 16 hours of the test, the number of insects staying on each device was recorded. The tobacco beetles staying in the device were recorded as choosing the odor source, and the tobacco beetles staying in other places in the box were recorded as not choosing, and their data were not included in the statistical analysis. All tests were carried out in a climate-controlled laboratory (29±1℃, 70±5%RH). After the test, all utensils were wiped with anhydrous ethanol and dried in an oven at 60℃.

[0052] (5) Finally, the number of different odor sources selected by tobacco beetles was counted, and statistical analysis software was used to calculate whether there was a significant difference.

[0053] Test results

[0054] For free-choice trials, the results are Figure 4 As shown, the results showed that methyl benzoate had a significant repellent effect on tobacco beetles.

[0055] 3. Fumigation test

[0056] (1) Add 20 adult tobacco beetles to a 250 mL conical flask without food. Add 0.0165 mL of different concentrations (20 g L -1 , 65g L -1 , 110g L -1 , 155g L -1 , 200g L -1 ) was dripped onto a 1 cm × 5 cm filter paper strip, which was then pasted onto a transparent tape. The transparent tape was pasted onto the opening of the conical flask, and the edges were then tightly wrapped with a wine sealing film to ensure air tightness, so that the filter paper strip was suspended on the inside of the flask mouth. A thin layer of polytetrafluoroethylene liquid was applied to the neck of the conical flask to prevent tobacco beetle from directly contacting the compound. During fumigation, the conical flask was placed in a climate-controlled incubator (29 ± 1 °C, 70 ± 5% RH).

[0057] (2) After 24 hours of fumigation, the mortality rate of tobacco beetles was counted. The beetles that did not move at all when moved with a brush were considered dead. Statistical analysis software was used to calculate whether there was a significant difference in mortality between the different fumigation concentrations of methyl benzoate.

[0058] (3) Finally, the fumigation test was repeated using the minimum lethal concentration of methyl benzoate in the presence of 5 g of food, and the mortality rate was calculated.

[0059] Test results

[0060] Effect of methyl benzoate on the mortality of tobacco beetles after fumigation in containers for 24 hours Figure 5 As shown in Figure 2, in the absence of food, the minimum lethal concentration of methyl benzoate to tobacco beetles is 110 g L -1 ; The same concentration, in the presence of 5g of food, still had a mortality rate of 96.67% against tobacco beetles

[0061] Example 2 Drugs only include 3-formylbenzoic acid methyl ester

[0062] 1. “Y” type olfactometer test

[0063] (1) Different concentrations of methyl 3-formylbenzoate (200 ppm, 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm) and the solvent anhydrous ethanol were used as odor sources.

[0064] (2) The air was filtered through activated carbon, humidified by passing through a wide-mouth bottle containing distilled water, and then passed through two separate air flow meters (150 mL min -1 ), then passed through the odor source, and finally entered the "Y"-shaped olfactometer (stem length 10 cm, two arms 10 cm long and 75°, inner diameter 1.5 cm), and all parts were connected by silicone tubes with a diameter of 0.6 cm.

[0065] (3) Place a single adult tobacco beetle at the base of the stem of a "Y"-shaped olfactometer, and then observe its position for 5 minutes. When the tobacco beetle moves beyond the threshold line in the middle of any arm for at least 10 seconds, it is recorded as having chosen the odor source. Tobacco beetles that did not make a choice during the observation time were recorded as not making a choice, and their data were not included in the statistical analysis. Each tobacco beetle was tested only once, and a total of 40 tobacco beetles were tested for each treatment. All tests were conducted between 9:00 and 18:00 in a climate-controlled laboratory (29±1℃, 70±5%RH). After testing every 10 tobacco beetles, the position of the odor source and its subsequent devices was reversed to avoid positional deviation. After the test, all glassware was washed with anhydrous ethanol and dried in an oven at 60℃.

[0066] (4) Finally, the number of different odor sources selected by tobacco beetles was counted, and the DPS statistical analysis software was used to calculate whether there was a significant difference.

[0067] Test results

[0068] First, we measured the effects of methyl 3-formylbenzoate on tobacco beetles at low concentrations (10 ppm) and high concentrations (4000 ppm). Figure 6 The results showed that methyl 3-formylbenzoate had a significant repellent effect on tobacco beetles at high concentrations.

[0069] We then determined the minimum effective concentration of methyl 3-formylbenzoate for the repellent effect on tobacco beetles. Figure 7 The results show that the minimum effective concentration of methyl 3-formylbenzoate is 500 ppm.

[0070] 2. Free-choice test

[0071] (1) Methyl 3-formylbenzoate at a concentration of 500 ppm and anhydrous ethanol as a solvent were used as odor sources.

[0072] (2) Take 40 tobacco beetles, put them into a clean 250 mL conical bottle, cover with a sealing film, poke small holes in the film, and starve them for 8 hours in a climate-controlled incubator (29±1℃, 70±5%RH) until ready for use in the experiment.

[0073] (3) Weigh 2.5 g of food (a mixture of oatmeal flour and whole wheat flour in a mass ratio of 7:3) and spread it evenly in a 6-cm diameter plastic culture dish. Then, nest a 9-cm diameter plastic culture dish and wrap two circles of medical tape around the outside of the 9-cm plastic culture dish. The tape is coated with 0.4 mL of methyl 3-formylbenzoate, forming a food + odor source device.

[0074] (4) During the test, the food + odor source 1 device was placed in a plastic box (length 57 cm, width 57 cm, height 25 cm) at two of the four corners, and the food + odor source 2 device was placed at the other two corners. 40 tobacco beetles were placed at the center of the plastic box and released (e.g. Figure 3 As shown), the plastic box was covered with breathable black cotton cloth to avoid the influence of light. After 16 hours of the test, the number of insects staying on each device was recorded. The tobacco beetles staying in the device were recorded as choosing the odor source, and the tobacco beetles staying in other places in the box were recorded as not choosing, and their data were not included in the statistical analysis. All tests were carried out in a climate-controlled laboratory (29±1℃, 70±5%RH). After the test, all utensils were wiped with anhydrous ethanol and dried in an oven at 60℃.

[0075] (5) Finally, the number of different odor sources selected by tobacco beetles was counted, and statistical analysis software was used to calculate whether there was a significant difference.

[0076] Test results

[0077] For free-choice trials, the results are Figure 8 shown.

[0078] 3. Fumigation test

[0079] (1) Add 20 adult tobacco beetles to a 250 mL conical flask without food. Add 0.0165 mL of different concentrations (20 g L-1 , 65g L -1 , 110g L -1 , 155g L -1 , 200g L -1 ) was dripped onto a 1 cm × 5 cm filter paper strip, which was then pasted onto a transparent tape. The transparent tape was pasted onto the opening of the conical flask, and the edge was then tightly wrapped with a wine sealing film to ensure air tightness, so that the filter paper strip was suspended on the inside of the flask mouth. A thin layer of polytetrafluoroethylene liquid was applied to the neck of the conical flask to prevent tobacco beta from directly contacting the compound. During fumigation, the conical flask was placed in a climate-controlled incubator (29 ± 1 °C, 70 ± 5% RH).

[0080] (2) After 24 hours of fumigation, the mortality rate of tobacco beetles was counted. The beetles that were completely motionless when moved with a brush were considered dead. Statistical analysis software was used to calculate whether there was a significant difference in mortality between the different fumigation concentrations of 3-formylbenzoic acid methyl ester.

[0081] (3) Finally, the fumigation test was repeated in the presence of 5 g of food using the minimum lethal concentration of 3-formylbenzoic acid methyl ester, and the mortality rate was calculated.

[0082] Test results

[0083] Effect of methyl 3-formylbenzoate on the mortality of tobacco beetles after 24 hours of fumigation in containers Fig. 9 As shown, in the absence of food, the minimum lethal concentration of methyl 3-formylbenzoate to tobacco beetles is 200g L-1; the same concentration, when there is 5g of food, still has a mortality rate of up to 93.33%.

[0084] Example 3: The drug contains both methyl benzoate and 3-formylbenzoic acid methyl ester

[0085] 1. “Y” type olfactometer test

[0086] (1) 200 ppm of methyl benzoate, different concentrations (200 ppm, 500 ppm) of methyl 3-formylbenzoate and solvent anhydrous ethanol were used as odor sources.

[0087] (2) The air was filtered through activated carbon, humidified by passing through a wide-mouth bottle containing distilled water, and then passed through two separate air flow meters (150 mL min -1 ), then passed through the odor source, and finally entered the "Y"-shaped olfactometer (stem length 10 cm, two arms 10 cm long and 75°, inner diameter 1.5 cm), and all parts were connected by silicone tubes with a diameter of 0.6 cm.

[0088] (3) Place a single adult tobacco beetle at the base of the stem of a "Y"-shaped olfactometer, and then observe its position for 5 minutes. When the tobacco beetle moves beyond the threshold line in the middle of any arm for at least 10 seconds, it is recorded as having chosen the odor source. Tobacco beetles that did not make a choice during the observation time were recorded as not making a choice, and their data were not included in the statistical analysis. Each tobacco beetle was tested only once, and a total of 40 tobacco beetles were tested for each treatment. All tests were conducted between 9:00 and 18:00 in a climate-controlled laboratory (29±1℃, 70±5%RH). After testing every 10 tobacco beetles, the position of the odor source and its subsequent devices was reversed to avoid positional deviation. After the test, all glassware was washed with anhydrous ethanol and dried in an oven at 60℃.

[0089] (4) Finally, the number of different odor sources selected by tobacco beetles was counted, and statistical analysis software DPS was used to calculate whether there was a significant difference.

[0090] Test results

[0091] First, we determined the effects of 200 ppm methyl benzoate combined with different concentrations of 3-formylbenzoic acid methyl ester on tobacco beetle. Fig.10 The results showed that 200 ppm of methyl benzoate mixed with 2.5 times the concentration of 3-formylbenzoic acid methyl ester had a significant repellent effect on tobacco beetles.

[0092] Therefore, we determined that the minimum effective concentration ratio of methyl benzoate for the repellent effect on tobacco beetles is 1:2.5.

[0093] 2. Free-choice test

[0094] (1) Methyl benzoate at a concentration of 200 ppm, methyl 3-formylbenzoate at different concentrations (200 ppm, 500 ppm), and anhydrous ethanol as a solvent were used as odor sources.

[0095] (2) Take 40 tobacco beetles, put them into a clean 250 mL conical bottle, cover with a sealing film, poke small holes in the film, and starve them for 8 hours in a climate-controlled incubator (29±1℃, 70±5%RH) until ready for use in the experiment.

[0096] (3) Weigh 2.5 g of food (a mixture of oatmeal flour and whole wheat flour in a mass ratio of 7:3) and spread it evenly in a plastic culture dish with a diameter of 6 cm. Then, nest a plastic culture dish with a diameter of 9 cm. Wrap two circles of medical tape on the outside of the 9 cm plastic culture dish, and the tape is coated with 0.4 mL of methyl benzoate, forming a food + odor source device.

[0097] (4) During the test, the food + odor source 1 device was placed in a plastic box (length 57 cm, width 57 cm, height 25 cm) at two of the four corners, and the food + odor source 2 device was placed at the other two corners. 40 tobacco beetles were placed at the center of the plastic box and released (e.g. Figure 3 As shown), the plastic box was covered with breathable black cotton cloth to avoid the influence of light. After 16 hours of the test, the number of insects staying on each device was recorded. The tobacco beetles staying in the device were recorded as choosing the odor source, and the tobacco beetles staying in other places in the box were recorded as not choosing, and their data were not included in the statistical analysis. All tests were carried out in a climate-controlled laboratory (29±1℃, 70±5%RH). After the test, all utensils were wiped with anhydrous ethanol and dried in an oven at 60℃.

[0098] (5) Finally, the number of different odor sources selected by tobacco beetles was counted, and statistical analysis software was used to calculate whether there was a significant difference.

[0099] Test results

[0100] For free-choice trials, the results are Fig.11 As shown, the results indicate that the combination of 200 ppm methyl benzoate and 2.5 times the concentration of 3-formylbenzoic acid methyl ester has a synergistic effect relative to both the solvent and 200 ppm methyl benzoate, and has a significant repellent effect on tobacco beetles.

[0101] As can be seen from the above embodiments, the present invention provides a drug for repelling or fumigating tobacco beetles and its application, wherein the drug comprises methyl benzoate and / or methyl 3-formylbenzoate. The present invention finds that methyl benzoate alone at more than 200 ppm, methyl 3-formylbenzoate at more than 500 ppm, or a combination of the two can produce a significant repellent effect on tobacco beetles in both the "Y" type olfactometer test and the free choice test. At the same time, methyl benzoate and methyl 3-formylbenzoate can produce a significant repellent effect on tobacco beetles in the concentration of 110 g L -1 and 200g L -1 The fumigation effect on tobacco beetles at the above concentrations reaches 100%. Methyl benzoate, methyl 3-formylbenzoate or a combination of the two can effectively reduce the use of traditional fumigants, are more environmentally friendly, and are of great significance in the prevention and control of tobacco beetles.

[0102] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A drug for repelling tobacco beetles, characterized in that: The drugs are methyl benzoate and methyl 3-formylbenzoate; The concentration of methyl 3-formylbenzoate in the drug is 2.5 times that of methyl benzoate.

2. Use of the drug according to claim 1 in the preparation of a tobacco beetle repellent.

3. The use according to claim 2, characterized in that: When the drug is used as a tobacco beetle repellent, the minimum effective concentration of methyl benzoate is 200 ppm, and the minimum effective concentration of methyl 3-formylbenzoate is 500 ppm.

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