An oil-soluble plant composition with soothing and skin-revitalizing effects and its applications

Abstract

The present invention discloses an oil-soluble plant composition with soothing and skin-revitalizing effects and its application. The raw materials of its active ingredients are 9-15 parts of rosemary, 1-5 parts of chamomile flowers, 10-16 parts of evening primrose, and 3-8 parts of phytosterol esters. The plant composition provided by the present invention utilizes the technical scheme of compounding rosemary extract, chamomile flower extract, evening primrose oil, and phytosterol esters. The four efficacy components synergistically enhance the effects. It not only has excellent effects of repairing the skin barrier and soothing, but also can effectively improve the skin glossiness and roughness. Moreover, it has a mild texture, is not easy to cause allergies, and is suitable for a wide range of people.

Description

Technical Field

[0001] The present invention relates to a natural extract, and more particularly to an oil-soluble plant composition having soothing and skin-revitalizing effects and its applications. Background Art

[0002] Most of the common traditional skin care products on the market at present are products made by mixing chemical raw materials, synthetic raw materials and chemical additives. Some of the substances contained therein, such as chemical synthetic additives, preservatives, and even heavy metal elements, are likely to induce various skin problems such as redness, allergy, and peeling, and are more unsuitable for people with sensitive skin or skin problems such as acne and inflammation. Compared with normal skin, sensitive skin is more prone to skin irritation. Therefore, there is an urgent need to develop a product with significant anti-allergic and soothing effects to reduce the irritation of cosmetics to human skin.

[0003] Sensitive skin is characterized by a relatively thin epidermis protective layer, obvious capillaries, and is prone to allergic symptoms when stimulated by environmental factors, seasonal changes or contact substances. When allergic symptoms occur, it will show skin inflammatory reactions such as itching, desquamation, and even burning, stinging, and redness.

[0004] The causes of sensitive skin are not caused by a single factor and are uncertain. The main possible factors leading to allergic symptoms are as follows: 1) The skin barrier function is damaged, which is an important reason for most people with sensitive skin at present. Due to the weakness of the epidermal stratum corneum, the skin barrier function declines, and external environmental sensitizing factors are more likely to enter, resulting in skin inflammation. 2) Frequent inflammatory reactions lead to further damage to the skin barrier. Since sensitive skin often shows inflammatory reactions due to external factor stimulation, the stratum corneum often appears damaged, and due to gene expression, it cannot be perfectly restored, making the skin barrier more vulnerable. 3) Over-reaction of the subcutaneous nervous system. Because sensitive skin often shows allergic symptoms, the nervous system makes frequent stress responses, resulting in enhanced nervous system responses. 4) The living environment is prone to contact with allergens, such as food allergies, animal and plant allergies, and photoallergies caused by ultraviolet rays, all of which will cause damage to the skin protective layer to a certain extent.

[0005] Most of the existing products on the market that claim to have soothing and repairing effects are mainly chemically synthesized soothers or water-soluble soothers, and their effects are relatively single, which limits their applications in cosmetics, especially in the field of color cosmetics. In summary, there is an urgent need to develop a safe, non-irritating, natural plant-derived, effective and stable oil-soluble soother with multiple skin-revitalizing effects to solve the defects existing in the prior art. Summary of the Invention

[0006] The object of the present invention is to overcome at least one deficiency of the prior art, and to provide an oil-soluble plant composition with soothing and skin-revitalizing effects and its application.

[0007] The technical solution adopted by the present invention is as follows:

[0008] In a first aspect, the present invention provides an oil-soluble plant composition with soothing and skin-revitalizing effects, and the raw materials of its active ingredients are rosemary, chamomile, evening primrose, and phytosterol esters.

[0009] In some examples, the active ingredient is an oil extract of the raw materials.

[0010] In some examples, the mass ratio of the raw materials of the active ingredient is: 9-15 parts of rosemary, 1-5 parts of chamomile, 10-16 parts of evening primrose, and 3-8 parts of phytosterol esters.

[0011] In some examples, the preparation method of the plant composition includes the following steps:

[0012] 1) Crushing rosemary, chamomile, and evening primrose to 60-100 meshes to obtain medicinal powder;

[0013] 2) Taking the rosemary medicinal powder and chamomile medicinal powder in step 1, placing them in an extraction container, adding an extraction solvent for extraction, and then performing solid-liquid separation to collect the filtrate to obtain an extract;

[0014] 3) Placing the evening primrose medicinal powder in step 1 in a subcritical extraction kettle, introducing an extraction agent, performing extraction and separation treatment, and collecting the extract to obtain evening primrose oil;

[0015] 4) Placing the extract obtained in step 2 and the evening primrose oil obtained in step 3 in a mixing tank, adding phytosterol esters, mixing and stirring evenly, adding activated clay, stirring and adsorbing, then performing solid-liquid separation, and collecting the filtrate to obtain a refined plant compound oil;

[0016] 5) Separating the refined compound oil obtained in step 4 with a ceramic membrane with a pore size of 0.05-0.1 μm, and collecting the filtrate to obtain a plant compound extract.

[0017] In some examples, the extraction solvent in step 2) is selected from at least one of triglyceride caprylate / caprate, isocetyl palmitate, ethylhexyl palmitate, isopropyl palmitate, squalane, medical white oil, olive oil, camellia oil, and limnanthes alba seed oil.

[0018] In some examples, the dosage of the extraction solvent in step 2) is 3-10 times that of the plant compound medicinal powder.

[0019] In some examples, the extraction rotation speed in step 2) is 60-90 rpm, the extraction temperature is 25-45 °C, and the extraction time is 60-120 min.

[0020] In some examples, the extractant in step 3) is selected from at least one of water, propane, butane, dimethyl ether, and tetrafluoroethane.

[0021] In some examples, the extraction time in step 3) is 30-90 min, the extraction pressure is 0.3-0.5 MPa, and the extraction temperature is 30-50 °C.

[0022] In some examples, the phytosterol ester in step 4) is at least one of phytosterol macadamiate, phytosterol rapeseed oil glycerides, phytosterol rapeseed oleate, phytosterol isostearyl dimlinoleate, phytosterol isostearate, and phytosterol oleate.

[0023] In some examples, the addition amount of activated clay in step 4) is 2-5% of the mass of the mixed solution, the adsorption temperature is 75-90 °C, and the adsorption time is 30-60 min.

[0024] In a second aspect, the present invention provides an oil-soluble composition with soothing and skin-activating effects, including excipients and active ingredients, and the active ingredient is the plant compound extract described in the first aspect of the present invention.

[0025] In some examples, the mass addition amount of the plant compound extract is 0.1-10%.

[0026] In some examples, the composition is a cream, lotion, aqueous solution, oil, powder, gel, essence, mask, or skin care products or cleaning products for washing and caring.

[0027] The beneficial effects of the present invention are:

[0028] The plant composition provided by the present invention, rosemary has antibacterial, anti-inflammatory, antioxidant and other effects, can inhibit the release of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-17, MMP-3, etc., and has an obvious anti-inflammatory effect; Matricaria chamomilla has the effects of antihistamine and anti-hyaluronic acid, can reduce the permeability of capillaries, can enhance the regeneration and repair process, and weaken the allergic reaction; evening primrose can inhibit the allergic reaction of inflammation such as atopic dermatitis, can improve eczema, allergic and other inflammatory reactions, and promote wound healing; phytosterol esters can maintain the moisture on the skin surface, promote skin metabolism, inhibit skin inflammation, and can prevent sunburn erythema and skin aging. The technical solution of the present invention uses the compounding of rosemary, Matricaria chamomilla, evening primrose, and phytosterol esters. The four active ingredients synergistically enhance the effect, have excellent skin barrier repair and soothing effects, can effectively improve the skin gloss and roughness, and have a mild texture, are not easy to be allergic, and are suitable for a wide range of people. Detailed implementation mode

[0029] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0030] Rosemary is the leaf of Rosmarinus officinalis Linn. of the Labiatae family, with a pungent taste, warm nature, and belongs to the lung, stomach, and spleen meridians. It has the effects of diaphoresis, invigorating the spleen, calming the nerves, and relieving pain. It is mainly used to treat various headaches and prevent early hair loss. Rosemary mainly contains volatile oils and phenolic acid components, and also contains flavonoids, diterpenoids, triterpenoids and other components, and has antibacterial, anti-inflammatory, antioxidant and other effects. The liposoluble components of rosemary have obvious inhibitory effects on Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Through mouse experiments, it can inhibit the release of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-17, MMP-3, etc., and has an obvious anti-inflammatory effect.

[0031] Matricaria chamomilla L. is the dried flower of the Matricaria genus of the Compositae family, with a pungent and slightly bitter taste, cool nature, and enters the lung meridian. It has the effects of clearing heat and detoxifying, relieving cough and asthma, and dispelling wind and dampness. It is used for the treatment of diseases such as cold and fever, sore throat, cough and asthma due to lung heat, arthralgia due to heat, and sores and boils. The components such as chamazulene, farnesene, oxide of bisabolol, and spathulenol in its volatile oil have good antibacterial and anti-inflammatory effects, can inhibit the release of histamine and 5-hydroxytryptamine, have the effects of antihistamine and anti-hyaluronic acid, and thus reduce the permeability of capillaries. Matricaria chamomilla can enhance the regeneration and repair process, weaken the allergic reaction, and also has certain local anesthetic effects, and can be used for bronchial asthma, rheumatic fever, allergic gastroenteritis, eczema, etc.

[0032] Evening primrose (Oenothera biennis L.) is a plant of the genus Oenothera in the family Onagraceae. It is sweet and bitter in taste, warm in nature, and enters the liver and kidney meridians. It has the effects of dispelling wind and dampness, and strengthening muscles and bones. It is applicable to wind-cold-damp arthralgia and weak muscles and bones. Evening primrose oil is rich in beneficial ω-6 fatty acids, γ-linolenic acid, linoleic acid, vitamins C, E, B6, B5 and other compounds. Among them, γ-linolenic acid can inhibit the allergic reactions of inflammation such as atopic dermatitis, improve inflammatory reactions such as eczema and allergy, promote wound healing, promote nail development, and solve hair problems. Evening primrose oil has obvious effects of reducing blood lipid and antiplatelet aggregation, and can reduce serum total cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol.

[0033] Phytosterol esters are products formed by esterification of two natural active ingredients, phytosterols extracted from vegetable oils and oleic acid. They have better fat solubility and biological activity than phytosterols. They have the effects of reducing cholesterol, preventing coronary artery sclerosis, and reducing the occurrence of cardiovascular and cerebrovascular diseases. Phytosterol esters can also promote wound healing and have a good conditioning effect on ulcers. At the same time, they have high permeability to the skin, can maintain the moisture on the skin surface, promote skin metabolism, inhibit skin inflammation, and can prevent sunburn erythema and skin aging.

[0034] The mass fraction compositions of the plant compositions in the examples and comparative examples of the present invention are shown in Table 1 below. Among them, in Comparative Example 7, chamomile was replaced with Matricaria recutita which has similar functions. Both chamomile and Matricaria recutita belong to the herbaceous Compositae family and have the effect of clearing heat and detoxifying. Clinically, they can be used to relieve heat-toxicity syndromes and assist in the treatment of diseases such as sore throat and damp-heat jaundice. The preparation methods of Examples 1 to 7 are as described below.

[0035] Table 1

[0036] Rosemary / part Matricaria flower / part Evening primrose / part Phytosterol esters / part Example 1 12 3 13 5 Example 2 9 1 16 8 Example 3 15 5 10 3 Example 4 10 4 15 7 Example 5 13 2 12 4 Example 6 12 3 13 5 Example 7 12 3 13 5 Comparative Example 1 12 0 0 0 Comparative Example 2 0 0 13 0 Comparative Example 3 0 3 0 5 Comparative Example 4 12 0 13 Comparative Example 5 12 5 0 5 Comparative Example 6 0 3 13 5 Comparative Example 7 12 3 13 5

[0037] Example 1

[0038] An oil-soluble plant composition with soothing and skin-revitalizing effects, and its preparation method successively includes the following steps:

[0039] Step 1: Weigh rosemary, chamomile flower, and evening primrose, and pulverize them to 80 meshes to obtain medicinal powder;

[0040] Step 2: Take the rosemary medicinal powder and chamomile flower medicinal powder from Step 1, place them in a Chinese herbal medicine directional extraction device, add 3 times the extraction solvent caprylic / capric triglyceride for extraction, the extraction rotation speed is 80 rpm, the extraction temperature is 25°C, and the extraction time is 90 min. The obtained extraction material is subjected to solid-liquid separation by centrifugation, and the filtrate is collected to obtain an extract;

[0041] Step 3: Place the evening primrose medicinal powder obtained in Step 1 into a subcritical extraction kettle, introduce the extraction agent butane, with an extraction time of 45 minutes, an extraction pressure of 0.4 MPa, and an extraction temperature of 45 °C. After extraction and separation, collect the extract to obtain evening primrose oil;

[0042] Step 4: Place the extract obtained in Step 2 and the evening primrose oil obtained in Step 3 into a mixing tank, add phytosterol low-erucic rapeseed oleate, mix and stir evenly, add activated clay accounting for 3% of the mass of the mixed solution, with an adsorption temperature of 80 °C and an adsorption time of 45 minutes; after stirring and adsorption, perform solid-liquid separation and collect the filtrate to obtain a refined plant compound oil;

[0043] Step 5: Separate the refined compound oil obtained in Step 4 with a ceramic membrane having a pore size of 0.08 μm, and collect the filtrate to obtain a plant compound extract.

[0044] Example 2

[0045] Step 1: Weigh rosemary, chamomile, and evening primrose, and crush them to 60 mesh to obtain medicinal powder;

[0046] Step 2: Take the rosemary medicinal powder and chamomile medicinal powder obtained in Step 1, place them in a Chinese herbal medicine directional extraction device, add 5 times the extraction solvent ethylhexyl palmitate for extraction, with an extraction rotation speed of 60 rpm, an extraction temperature of 45 °C, and an extraction time of 120 minutes. The obtained extraction material is subjected to solid-liquid separation by centrifugation, and the filtrate is collected to obtain an extract;

[0047] Step 3: Place the evening primrose medicinal powder obtained in Step 1 into a subcritical extraction kettle, introduce the extraction agent propane, with an extraction time of 90 minutes, an extraction pressure of 0.5 MPa, and an extraction temperature of 30 °C. After extraction and separation, collect the extract to obtain evening primrose oil;

[0048] Step 4: Place the extract obtained in Step 2 and the evening primrose oil obtained in Step 3 into a mixing tank, add phytosterol oleate, mix and stir evenly, add activated clay accounting for 5% of the mass of the mixed solution, with an adsorption temperature of 75 °C and an adsorption time of 60 minutes. After stirring and adsorption, perform solid-liquid separation and collect the filtrate to obtain a refined plant compound oil;

[0049] Step 5: Separate the refined compound oil obtained in Step 4 with a ceramic membrane having a pore size of 0.1 μm, and collect the filtrate to obtain a plant compound extract.

[0050] Example 3

[0051] Step 1: Weigh rosemary, chamomile, and evening primrose, and crush them to 70 mesh to obtain medicinal powder;

[0052] Step 2: Take the rosemary medicinal powder and chamomile medicinal powder from Step 1, place them in a Chinese herbal medicine directional extraction device, add 7 times the extraction solvent Limnanthes alba seed oil for extraction, the extraction rotation speed is 90 rpm, the extraction temperature is 35 °C, and the extraction time is 60 min. The obtained extraction material is subjected to solid-liquid separation by centrifugation, and the filtrate is collected to obtain the extract;

[0053] Step 3: Take the evening primrose medicinal powder from Step 1 and place it in a subcritical extraction kettle, introduce the extraction agent tetrafluoroethane, the extraction time is 60 min, the extraction pressure is 0.3 MPa, and the extraction temperature is 50 °C. After extraction and separation treatment, the extract is collected to obtain evening primrose oil;

[0054] Step 4: Place the extract obtained in Step 2 and the evening primrose oil obtained in Step 3 in a mixing tank, add phytosterol macadamiate, mix and stir evenly, add 2% of the mass of the mixed solution of activated clay, the adsorption temperature is 90 °C, the adsorption time is 30 min, after stirring and adsorption, carry out solid-liquid separation, and collect the filtrate to obtain the refined plant compound oil;

[0055] Step 5: Separate the refined compound oil obtained in Step 4 with a ceramic membrane with a pore size of 0.05 μm, and collect the filtrate to obtain the plant compound extract.

[0056] Example 4

[0057] Step 1: Weigh rosemary, chamomile, and evening primrose, and pulverize them to 100 mesh to obtain medicinal powder;

[0058] Step 2: Take the rosemary medicinal powder and chamomile medicinal powder from Step 1, place them in a Chinese herbal medicine directional extraction device, add 10 times the extraction solvent squalane for extraction, the extraction rotation speed is 70 rpm, the extraction temperature is 40 °C, and the extraction time is 90 min. The obtained extraction material is subjected to solid-liquid separation by centrifugation, and the filtrate is collected to obtain the extract;

[0059] Step 3: Take the evening primrose medicinal powder from Step 1 and place it in a subcritical extraction kettle, introduce the extraction agent dimethyl ether, the extraction time is 30 min, the extraction pressure is 0.5 MPa, and the extraction temperature is 40 °C. After extraction and separation treatment, the extract is collected to obtain evening primrose oil;

[0060] Step 4: Place the extract obtained in Step 2 and the evening primrose oil obtained in Step 3 in a mixing tank, add phytosterol isostearate, mix and stir evenly, add 4% of the mass of the mixed solution of activated clay, the adsorption temperature is 85 °C, the adsorption time is 40 min, after stirring and adsorption, carry out solid-liquid separation, and collect the filtrate to obtain the refined plant compound oil;

[0061] Step 5: Separate the refined compound oil obtained in Step 4 with a ceramic membrane with a pore size of 0.07 μm, and collect the filtrate to obtain the plant compound extract.

[0062] Example 5

[0063] Step 1: Weigh rosemary, chamomile flower, and evening primrose, crush them to 70 mesh to obtain medicinal powder;

[0064] Step 2: Take the rosemary medicinal powder and chamomile flower medicinal powder from Step 1, place them in a Chinese herbal medicine directional extraction device, add 4 times the extraction solvent olive oil for extraction, the extraction rotation speed is 75 rpm, the extraction temperature is 30 °C, and the extraction time is 100 min. The obtained extraction material is subjected to solid-liquid separation by centrifugation, and the filtrate is collected to obtain an extract;

[0065] Step 3: Take the evening primrose medicinal powder from Step 1 and place it in a subcritical extraction kettle, introduce the extraction agent propane, the extraction time is 30 - 90 min, the extraction pressure is 0.4 MPa, and the extraction temperature is 45 °C. After extraction and separation treatment, the extract is collected to obtain evening primrose oil;

[0066] Step 4: Place the extract obtained in Step 2 and the evening primrose oil obtained in Step 3 in a mixing tank, add phytosterol low erucic acid rapeseed oil glycerides, mix and stir evenly, add 4% of activated clay based on the mass of the mixed solution, the adsorption temperature is 80 °C, and the adsorption time is 50 min; after stirring and adsorption, solid-liquid separation is carried out, and the filtrate is collected to obtain a refined plant compound oil;

[0067] Step 5: Separate the refined compound oil obtained in Step 4 with a ceramic membrane with a pore size of 0.1 μm, and collect the filtrate to obtain a plant compound extract.

[0068] Example 6

[0069] The preparation method of an oil-soluble plant composition with soothing and skin-revitalizing effects described in this example is the same as that of Example 1, except that in Step 2, 15 times the extraction solvent triglyceride caprylic / capric acid is added, and 1% of activated clay based on the mass of the mixed solution is added in Step 4.

[0070] Example 7

[0071] The preparation method of an oil-soluble plant composition with soothing and skin-revitalizing effects described in this example is the same as that of Example 1, except that the extraction temperature in Step 2 is 80 °C and the extraction pressure in Step 3 is 0.6 MPa.

[0072] The preparation methods of the plant compositions in Comparative Examples 1 - 7 are the same as those in Example 1.

[0073] Take the compositions obtained in Examples 1 to 7 and Comparative Examples 1 to 7, and prepare the corresponding natural soothing and skin-nourishing lotions according to the formulation in Table 2. The preparation method is as follows: Weigh and mix the raw materials in Phase A, heat them up to 80 °C, and stir until completely dissolved for standby. Weigh and mix the raw materials in Phase B, heat them up to 80 °C, stir until evenly mixed, and then add them to Phase A and emulsify for 5 minutes. Cool to room temperature to obtain the natural soothing and skin-nourishing lotion product. Then, conduct the following performance tests on the obtained natural soothing and skin-nourishing lotion.

[0074] Table 2

[0075]

[0076] Comparative experiment on the soothing effect of plant compositions

[0077] Transepidermal water loss (TEWL) refers to the water transported through the skin by passive diffusion, which reflects the quality of the skin barrier function. Generally, a low TEWL value indicates a good skin barrier function. For sensitive skin, the skin barrier function is somewhat damaged, and the TEWL will also be higher. Therefore, the change in TEWL can be used to reflect the change in the skin barrier function. When an allergic skin uses a soother, the TEWL value can be measured by the skin water loss test probe Tewameter TM300. The lower the TEWL value, the less water is lost through the skin, the better the skin barrier function, and the better the repair effect of the corresponding soother product on the skin barrier. Therefore, the repair effect of the plant composition on the skin barrier can be determined by the change in the TWEL value.

[0078] Skin heme reflects the condition of telangiectasia on the skin, and can reflect the inflammatory condition of the skin and the integrity of the skin barrier. When the skin is allergic, the higher the skin heme content, the more severe the flushing, indicating a more severe inflammatory condition. Therefore, when an allergic skin uses a soother, the change in the skin heme content can be measured by the heme test probe Mexameter MX18 to test the soothing and repair effect of the plant composition on allergic symptoms.

[0079] (1) Subjects: Select 84 subjects, 42 males and 42 females, aged 20 - 45 years. The subjects have no serious systemic diseases, no immunodeficiency or autoimmune diseases, no active allergic diseases, no history of allergies to skin care cosmetics, and have not used systemic hormonal drugs and immunosuppressants within 1 month. Randomly divide the subjects into 14 groups, with 6 people in each group, 3 males and 3 females in each group. Use the natural soothing and skin-nourishing lotions prepared with the plant compound extracts in the above examples and comparative examples to conduct a comparative experiment on the soothing effect.

[0080] (2) Test method: On the 0th day of the experiment, the subjects sat still for 30 minutes in a constant temperature and humidity environment (temperature (21±1) °C, humidity (40-60) %), and two circular areas with a diameter of 18 mm were marked at corresponding positions on the inner side of the left forearm, with a 3 cm interval between the two areas. A closed patch test was performed on the designated area on the inner side of the left forearm with a 2% SLS solution by mass fraction for 24 hours to induce erythema. After 24 hours of patching, the patch tester on the arm was removed, and at 6 hours, 2 days, and 5 days later, the skin parameter values of the transepidermal water loss (TEWL value) and skin red pigment content at the patch sites of the blank group and the experimental group were measured using a skin water loss test probe Tewameter TM300 and a heme test probe Mexameter MX18 respectively.

[0081] The experimental results of the comparison of the soothing effects of the examples and the comparative examples are shown in Table 3.

[0082] Table 3

[0083]

[0084]

[0085]

[0086] Among them, "n.s." indicates no significant difference, P≥0.05; "*" indicates a significant difference, 0.01≤P<0.05; "**" indicates a very significant difference, P<0.01.

[0087] From the test results of the transepidermal water loss, it can be seen that: (1) The soothing test results of Examples 1-5 show that after the subjects used the natural soothing and skin-revitalizing lotion product for 5 days, the skin barrier basically returned to the normal level, and the results were all significantly different (P<0.05), indicating that the plant composition product of the present invention has a significant effect on repairing the skin barrier. (2) The soothing test results of Examples 6-7 show that after the subjects used the natural soothing and skin-revitalizing lotion product for 5 days, the skin barrier was repaired to a certain extent but did not return to the normal level, but the results were still better than those of Comparative Examples 1-7. It shows that when the preparation process parameters are not within the specified range of the present invention, the skin barrier repair effect will be greatly weakened. (3) From the soothing test results of Comparative Examples 1-7, it can be seen that when only one or two functional raw materials are used, or other traditional Chinese medicines with similar functions are used, the repair effect on the skin barrier is not obvious, and there is still a large gap from the normal skin barrier function.

[0088] From the experimental results of skin red pigment content, it can be seen that: (1) The test results of Examples 1-5 show that after the subjects used the natural soothing and skin-nourishing lotion product for 5 days, the skin red pigment content basically returned to the normal level, and the results were all significantly different (P<0.05), indicating that the plant composition product of the present invention has a good effect on improving skin erythema and relieving skin inflammation. (2) From the soothing test results of Comparative Examples 1-7, when only one or two efficacy raw materials were used, or other traditional Chinese medicines with similar functions were replaced, the effect on improving skin erythema and relieving skin inflammation was not obvious, and there was still a large gap from the normal skin heme content.

[0089] From the test results in Table 3, it can be seen that the plant composition of the present invention has good effects of soothing skin allergy symptoms and repairing the skin barrier, and there is an obvious synergistic effect between the active raw materials.

[0090] Comparative experiment on the skin-nourishing effect of the plant composition

[0091] Use the VISIA-CR skin detection system to measure the skin L* value and the ratio SE of the skin texture area in the measured area of the subjects' faces W parameters, which can reflect the skin glossiness and skin roughness. The higher the skin L* value, the whiter the skin and the higher the skin glossiness; the lower the ratio SE of the skin texture area W value, the lower the skin roughness and the better the smoothness.

[0092] (1) Test subjects: 84 subjects were selected, 42 males and 42 females, aged 20-45 years. The subjects had no serious systemic diseases, no immune deficiencies or autoimmune diseases, no active allergic diseases, no history of allergies to skin care cosmetics, and had not used systemic hormonal drugs and immunosuppressants within 1 month. The subjects were randomly divided into 14 groups, with 6 people in each group, 3 males and 3 females. The natural soothing and skin-nourishing lotions of Examples 1-7 and Comparative Examples 1-7 were used for the comparative experiment on the skin-nourishing effect.

[0093] (2) Test method: The subjects continuously used the natural soothing and skin-nourishing lotion on the measured area of the face for 28 days. In an environment with a room temperature of 21±1°C and a relative humidity of 50±10%, the VISIA-CR skin detection system was used to detect the L* value and the ratio SE of the skin texture area in the measured area of the subjects' faces W and used the pre-use data as the self-control. The test results are shown in Table 4.

[0094] Table 4

[0095]

[0096] Among them, "n.s." indicates no significant difference, P≥0.05; "*" indicates significant difference, 0.01≤P<0.05; "**" indicates very significant difference, P<0.01.

[0097] Table 4 shows the test results of the skin rejuvenating effect of the plant composition: (1) After 28 days of using the natural soothing and skin rejuvenating lotion of Examples 1 to 5 by the subjects, the L* value of the cheek skin increased by an average of 9.90%, and the ratio of the skin texture area SEW decreased by an average of 9.67%, showing a very significant difference (P<0.01), indicating that the product of the present invention has a good effect of improving skin gloss and roughness. (2) After 28 days of using the natural soothing and skin rejuvenating lotion of Examples 6 to 7 by the subjects, the L* value of the cheek skin increased by an average of 5.89%, and the ratio of the skin texture area SEW decreased by an average of 5.64%, indicating that when the preparation process parameters are not within the scope of the present invention, its skin rejuvenating effect will decrease to a great extent. (3) After 28 days of using the natural soothing and skin rejuvenating lotion of Comparative Examples 1 to 7 by the subjects, the L* value of the cheek skin increased by an average of 2.08%, and the ratio of the skin texture area SEW decreased by an average of 2.65%, indicating that when using only one or two raw materials, or replacing them with other active raw material components with similar functions, the effect of improving skin gloss and roughness is not obvious.

[0098] The plant compound extract of the present invention has a repair effect on the skin barrier, and at the same time can significantly improve the skin gloss and roughness, and there is a clear synergistic effect among the active raw materials of each effect.

[0099] The above is a further detailed description of the present invention, and it should not be regarded as a limitation to the specific implementation of the present invention. For those of ordinary skill in the technical field to which the present invention belongs, any simple deduction or replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. An oil-soluble plant composition with soothing and skin-revitalizing effects, characterized in that, The raw materials of its active ingredients are rosemary, chamomile, evening primrose, and phytosterol esters. The mass ratio of the raw materials of the active ingredients is as follows: rosemary 9 - 15 parts, chamomile 1 - 5 parts, evening primrose 10 - 16 parts, and phytosterol esters 3 - 8 parts. The preparation method of the plant composition includes the following steps: 1) Crush rosemary, chamomile, and evening primrose to obtain medicinal powder; 2) Take the rosemary medicinal powder and chamomile medicinal powder from step 1, place them in an extraction container, add an extraction solvent for extraction, and then perform solid-liquid separation to collect the filtrate to obtain an extract. The dosage of the extraction solvent is 3 - 10 times the mass of the plant medicinal powder, the extraction rotation speed is 60 - 90 rpm, the extraction temperature is 25 - 45 °C, and the extraction time is 60 - 120 min. The extraction solvent is selected from at least one of triglyceride caprylic / capric acid, ethylhexyl palmitate, squalane, olive oil, and Limnanthes Alba seed oil; 3) Take the evening primrose medicinal powder from step 1 and place it in a subcritical extraction kettle, introduce an extractant, and after extraction and separation treatment, collect the extract to obtain evening primrose oil. The extraction time is 30 - 90 min, the extraction pressure is 0.3 - 0.5 MPa, and the extraction temperature is 30 - 50 °C. The extractant is selected from at least one of propane, butane, dimethyl ether, and tetrafluoroethane; 4) Place the extract obtained in step 2 and the evening primrose oil obtained in step 3 in a mixing tank, add phytosterol esters, mix and stir evenly, add activated clay, stir and adsorb, then perform solid-liquid separation, and collect the filtrate to obtain a refined plant compound oil. The phytosterol esters are at least one of phytosterol macadamiate, phytosterol rapeseed oil glycerides, phytosterol rapeseed oleate, phytosterol isostearate, and phytosterol oleate; 5) Separate the compound refined oil obtained in step 4 with a ceramic membrane with a pore size of 0.05 - 0.1 μm, and collect the filtrate to obtain a plant compound extract.

2. The plant composition according to claim 1, wherein The addition amount of the activated clay in step 4) is 2 - 5% of the mass of the mixed solution, the adsorption temperature is 75 - 90 °C, and the adsorption time is 30 - 60 min.

3. An oil-soluble composition with soothing and skin-revitalizing effects, comprising excipients and active ingredients, characterized in that, The efficacy ingredient is the plant compound extract described in claim 1 or 2, and the mass addition amount of the plant compound extract is 0.1 - 10%.

4. The composition according to claim 3, characterized in that, The composition is a cream, lotion, aqueous solution, oil, powder, gel, essence, facial mask, or skin care products or cleaning products for washing and caring.

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