Application of an amino acid metal complex in the preparation of bird repellent

Abstract

This invention discloses the application of amino acid metal complexes in the preparation of bird repellents. The amino acid metal complexes are one of the following: glycine metal complex, aspartic acid metal complex, phenylalanine metal complex, methionine metal complex, arginine metal complex, leucine metal complex, isoleucine metal complex, lysine metal complex, glutamic acid metal complex, threonine metal complex, serine metal complex, proline metal complex, valine metal complex, tryptophan metal complex, tyrosine metal complex, cysteine ​​metal complex, alanine metal complex, and histidine metal complex. Bird repellents prepared using amino acid metal complexes as the active ingredient can be used for seed dressing or spraying of crop seeds, or for spraying crop fruits, to repel a wider variety of bird species.

Description

Technical Field

[0001] This invention belongs to the field of chemical bird repellent technology, specifically relating to the application of an amino acid metal complex in the preparation of bird repellents. Background Technology

[0002] The absorption, transport, and metabolism of amino acids by plants, as well as their application in fertilizers and as phytostimulants, have been reported both domestically and internationally. Studies have shown that plants can directly absorb amino acid molecules from the soil. The transport, distribution, and metabolism of these absorbed amino acids vary depending on the type of amino acid, resulting in different physiological effects. Amino acids are easily decomposed by sunlight or degraded by natural microorganisms, leaving no toxic residues in the soil or plant bodies. Their degradation products can also serve as nutrients for crops, improving crop quality and yield. The application of these fertilizers is safe for humans and livestock and is pollution-free. Amino acid fertilizers promote plant growth and development, enhance stress resistance, improve soil conditions, and increase crop yield.

[0003] The inventors, in their research on amino acids as plant stimulants to promote crop seed germination and growth, resist external biotic and abiotic stresses, and accelerate fruit ripening and color change, discovered that the taste of amino acids is closely related to the size and hydrophobicity of their side chain groups. When the hydrophobicity of the amino acid side chain groups is low, they mainly have a sweet taste, such as glycine, aspartic acid, alanine, serine, and proline, and do not have a repellent effect on birds. When the hydrophobicity of the amino acid side chain groups is high, such as phenylalanine, leucine, isoleucine, valine, tryptophan, arginine, histidine, and tyrosine, they can stimulate birds' taste buds to produce a bitter taste, thereby preventing birds from feeding and acting as a bird deterrent. The inventors have applied for an invention patent for this (CN115316390 A).

[0004] Further research has shown that complexes formed by amino acids and certain metals through coordination bonds not only have better bird-repelling effects than the amino acids themselves, but also repel a wider variety of bird species, including large birds such as chickens and pheasants, to which amino acids are less effective. Some amino acids that do not inherently possess bird-repelling properties, such as glycine, aspartic acid, and alanine, can also effectively repel birds from feeding after forming metal complexes.

[0005] There is no publicly available information in the prior art regarding the use of amino acid metal complexes as bird repellents. Summary of the Invention

[0006] To address the aforementioned problems, this invention aims to provide an application of amino acid metal complexes in the preparation of bird repellents, thereby resolving the potential harm of existing bird repellents to the biological environment.

[0007] The technical solution adopted by the present invention to solve the above-mentioned technical problems is as follows:

[0008] The application of an amino acid metal complex in the preparation of bird repellents, wherein the amino acid metal complex is one of the following: glycine metal complex, aspartic acid metal complex, phenylalanine metal complex, methionine metal complex, arginine metal complex, leucine metal complex, isoleucine metal complex, lysine metal complex, glutamic acid metal complex, threonine metal complex, serine metal complex, proline metal complex, valine metal complex, tryptophan metal complex, tyrosine metal complex, cysteine ​​metal complex, alanine metal complex, and histidine metal complex.

[0009] Optionally, the application of the amino acid metal complex in the preparation of bird repellents, wherein the metal in the amino acid metal complex is one or more of zinc, manganese, magnesium, iron, copper and calcium.

[0010] Optionally, the application of the amino acid metal complex in the preparation of bird repellents, wherein the birds include: sparrows, white-rumped munias, magpies, spotted doves, domestic chickens, and pheasants.

[0011] The use of a pharmaceutical formulation in the preparation of a bird repellent, wherein the pharmaceutical formulation comprises the aforementioned amino acid metal complex.

[0012] Optionally, in the application of the pharmaceutical preparation in the preparation of bird repellents, the dosage form of the pharmaceutical preparation is selected from any one of the following: suspension concentrate, emulsion, water emulsion, microemulsion, microcapsule suspension, oil suspension, emulsifiable concentrate, soluble concentrate, soluble granules, soluble powder, water-dispersible granules, wettable powder, powder, granules, seed treatment suspension, seed treatment emulsion, seed treatment liquid, seed treatment dispersible powder, and seed treatment dry powder.

[0013] Optionally, in the application of the pharmaceutical formulation in the preparation of bird repellents, the amino acid metal complex accounts for 1%-90% of the weight percentage of the pharmaceutical formulation.

[0014] Optionally, in the application of the pharmaceutical formulation in the preparation of bird repellents, the amino acid metal complex accounts for 10%-50% of the weight percentage of the pharmaceutical formulation.

[0015] Optionally, in the pharmaceutical preparation, the amino acid is one or more selected from glycine, aspartic acid, phenylalanine, methionine, arginine, leucine, isoleucine, lysine, glutamic acid, and alanine.

[0016] Beneficial Effects: Compared with existing technologies, the bird repellent made from amino acid metal complexes, as the active ingredient in this invention, can repel a wider variety of birds when used for seed dressing or spraying crop seeds or fruits. This allows amino acids, which originally lack bird-repelling properties, to effectively repel birds after forming metal complexes. When used at the recommended dosage, it can effectively reduce bird feeding and damage to crop seeds and fruits without harming the birds. In addition to being safe for humans and livestock, easy to use, and low-cost, the bird repellent made from amino acid metal complexes can also promote the growth and development of crop seeds, seedlings, and fruits, leading to increased agricultural production and farmers' income. Detailed Implementation

[0017] The present invention will be further described in detail below with reference to specific embodiments, but the implementation of the present invention is not limited thereto. For process parameters not specifically noted, conventional techniques can be referred to.

[0018] Unless otherwise stated, the technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention pertains; units indicating the content of raw materials are based on parts by mass. Other raw materials and reagents not specifically mentioned in this invention refer to those commonly used in the art.

[0019] To address the problems of unstable bird-repelling effects, high dosage, high cost, safety hazards to humans and livestock, and environmental degradation associated with existing bird repellents, this invention provides the following technical solution:

[0020] The inventors' research shows that complexes formed by amino acids and certain metals through coordination bonds not only have better bird-repelling effects than the amino acids themselves, but also repel a wider variety of bird species, including large birds such as chickens and pheasants, to which amino acids are less effective. Some amino acids that have almost no bird-repelling effect on their own, such as glycine, aspartic acid, and alanine, can also effectively repel birds from feeding after forming metal complexes.

[0021] This invention employs amino acid-metal complexes, commonly used in the prior art as nutrients for humans, animals, and plants, as bird repellents. The amino acids include, but are not limited to, glycine, aspartic acid, phenylalanine, methionine, arginine, leucine, isoleucine, lysine, glutamic acid, threonine, serine, proline, valine, tryptophan, tyrosine, cysteine, alanine, and histidine. The metals include, but are not limited to, zinc, manganese, magnesium, iron, copper, and calcium. It should be noted that in this invention, when amino acids complex with metals, it can be two different amino acids complexing with one metal, or one amino acid complexing with two or more metals.

[0022] Based on the same inventive concept, the present invention also provides a pharmaceutical formulation in which the active ingredient is an amino acid metal complex. It is readily understood that the amino acid metal complex includes, but is not limited to, complexes formed by coordination bonds between amino acids such as glycine, aspartic acid, phenylalanine, methionine, arginine, leucine, isoleucine, lysine, glutamic acid, threonine, serine, proline, valine, tryptophan, tyrosine, cysteine, alanine, and histidine and metals such as zinc, manganese, magnesium, iron, copper, and calcium.

[0023] Various formulations can be formulated according to usage requirements, including but not limited to: suspension concentrates (SC), emulsions (SE), emulsions (EW), microemulsions (ME), microcapsule suspensions (CS), oil suspensions (OD), emulsifiable concentrates (EC), soluble concentrates (SL), soluble granules (SG), soluble powders (SP), water-dispersible granules (WG), wettable powders (WP), powders (DP), granules (GR), seed treatment suspensions (FS), seed treatment emulsions (ES), seed treatment liquids (LS), seed treatment dispersible powders (WS), and seed treatment dry powders (DS). By preparing the agent into different formulations, it can be suitable for different application environments and meet different application needs.

[0024] In this embodiment, the amino acid metal complex can account for 1% to 10%, 10% to 20%, 20% to 30%, 30% to 40%, 40% to 50%, 50% to 60%, 60% to 70%, 70% to 80%, or 80% to 90% of the weight of the drug formulation. For example, the amino acid metal complex accounts for 10% to 50% of the weight of the drug formulation. Controlling the content of the amino acid metal complex at 10% to 50% can achieve a better bird-repelling effect while reducing the amount of amino acid metal complex used, thereby reducing the cost of the drug.

[0025] The technical solutions provided by the present invention will be further explained and illustrated below by listing specific embodiments.

[0026] Formulation Example 1 (Suspension Formulation SC)

[0027] In a shearing reactor, the following materials are sequentially vacuum-introduced: 5.00% tristyrene-phenol polyoxyethylene ether phosphate, 3.00% sodium naphthalenesulfonate formaldehyde condensate, 3.00% octylphenol polyoxyethylene ether, 0.30% xanthan gum, 0.30% polysiloxane, 20.00% propylene glycol, and 0.30% 1,2-phenylpropylisothiazolin-3-one. Water is added to 100%, and the vent valve of the shearing reactor is opened. The manhole cover of the shearing reactor is opened, and the shearing machine is started for 10 minutes. The required amino acid metal complex (phenylalanine zinc complex) is then added to the shearing reactor. After shearing for a period of time, the shearing machine is turned off. The bottom valve of the shearing reactor is opened, and the cooling water valve of the sand mill is opened and kept unobstructed. The sand mill is started for two sand milling cycles. The milled material is transferred to the post-shearing reactor for shearing. After sampling and analysis, and if it passes the test, the material is discharged and filtered to obtain the amino acid metal complex suspension.

[0028] Formulation Example 2 (Seed Treatment Suspension FS)

[0029] In a shearing reactor, the following materials are sequentially vacuum-introduced: 0.50% styrene-phenol polyoxyethylene ether phosphate, 0.50% polyethylene oxide-propylene oxide monobutyl ether, 0.50% sodium naphthalenesulfonate formaldehyde condensate, 0.10% polysiloxane, 0.05% xanthan gum, 3.00% propylene glycol, 0.50% pigment red, 0.10% polyvinylpyrrolidone, and 0.10% 1,2-phenylpropylisothiazolin-3-one. Water is added to 100%, and the vent valve of the shearing reactor is opened. The manhole cover of the shearing reactor is opened, and the shearing machine is started for 10 minutes. The required amino acid metal complex (glycine manganese complex) is then added to the shearing reactor. After shearing for a period of time, the shearing machine is turned off. The bottom valve of the shearing reactor is opened, and the cooling water valve of the sand mill is opened and kept unobstructed. The sand mill is started for two sand milling cycles. The milled material is transferred to the post-shearing reactor for shearing. After sampling and analysis, and if it passes the test, the material is discharged and filtered to obtain the amino acid metal complex seed treatment suspension.

[0030] Formulation Example 3 (Wettable Powder WP)

[0031] The required amino acid metal complex (isoleucine calcium complex), sodium lignosulfonate 8.00%, sodium dodecyl sulfate 2.00%, and sodium methylene dinaphthalene sulfonate 7.00% were sequentially added to a stirred tank. Kaolin was added to bring the total to 100%. The mixer was turned on and stirred for 1.5 hours until completely homogeneous. An air jet mill was then turned on to pulverize the mixture, and the pulverized material was stirred and mixed for another 1.5 hours. After sampling and analysis, the amino acid metal complex wettable powder was obtained.

[0032] Formulation Example 4 (Water-dispersible granules WG)

[0033] In a stirred tank, the required amino acid metal complex (alanine copper complex), 10.00% sodium lignosulfonate, 15.00% alkyl naphthalene sulfonate formaldehyde condensate, 3.00% sodium ester sulfonate, and 50.00% sodium sulfate are added sequentially. Kaolin is added to bring the total to 100%. The mixer is turned on and stirred for 1 hour until completely homogeneous. The air jet mill is then turned on for pulverization, and the pulverized material is stirred and mixed for another 1.5 hours. Samples are taken for analysis. After passing the test, the material is discharged and transferred to a fluidized bed granulator for granulation. During granulation, the uniformity of the particles is observed. Once the granules are uniform, samples are taken for testing, and the amino acid metal complex water-dispersible granules are obtained.

[0034] Bioassay Examples:

[0035] The following examples illustrate how the inventors evaluated the refusal rate of bird repellents containing amino acid metal complexes by raising spotted doves (Spilopelia chinensis) (instead of magpies), white-rumped munias (Lonchura striata) (instead of sparrows), domestic chickens (Gallus domesticus), and pheasants (Phasianus colchicus) in artificial greenhouses.

[0036] Refusal rate = (Birds' feeding rate on the blank control crop - Birds' feeding rate on the treated crop) / Birds' feeding rate on the blank control crop * 100%.

[0037] Bioassay Example 1

[0038] A 10% suspension of amino acid metal complex was used to treat rice seeds with different doses, and the rejection rate was calculated based on the weight of rice seeds ingested by birds.

[0039] Table 1. Refusal rate of 10% SC amino acid metal complexes

[0040]

[0041] Bioassay Example 2

[0042] The amino acid metal complex 40% seed treatment suspension was used to treat rice seeds with different doses, and the rejection rate was calculated based on the weight of rice seeds ingested by birds.

[0043] Table 2. Refusal rate of amino acid metal complexes in 40% FS (Fetal Food Rejection)

[0044]

[0045]

[0046] Bioassay Example 3

[0047] The 25% wettable powder of amino acid metal complex was diluted with water and applied to rice seeds in different doses for seed dressing. The rejection rate was calculated based on the weight of rice seeds ingested by birds.

[0048] Table 3. Refusal rate of 25% WP containing amino acid metal complexes

[0049]

[0050] Bioassay Example 4

[0051] The 50% water-dispersible granules of amino acid metal complex were diluted with an appropriate amount of water and used to treat rice seeds with different dosages. The rejection rate was calculated based on the weight of rice seeds ingested by birds.

[0052] Table 4. Refusal rate of amino acid metal complexes at 50% WG

[0053]

[0054] The data from the above bioassay examples show that when the amino acid metal complex is applied to seeds at a concentration of 2 g / kg of active ingredient, it achieves a rejection rate of over 80% against white-rumped munias, spotted doves, domestic chickens, and pheasants, providing effective bird repellency for crop seeds. When the active ingredient concentration of the amino acid metal complex is increased to 4 g / kg of seed, the rejection rate against these birds reaches over 90%. At the same active ingredient dosage, the rejection rate of the amino acid metal complex against birds, especially large birds like domestic chickens and pheasants, is significantly higher than that of similar amino acids.

[0055] In summary, this invention provides the application of amino acid metal complexes in the preparation of bird repellents, wherein the amino acid is one or more selected from glycine, aspartic acid, phenylalanine, methionine, arginine, leucine, isoleucine, lysine, glutamic acid, threonine, serine, proline, valine, tryptophan, tyrosine, cysteine, alanine, and histidine, and the metal is one or more selected from zinc, manganese, magnesium, iron, copper, and calcium.

[0056] This invention relates to a bird repellent made from amino acid metal complexes as the active ingredient. Seed dressing with this repellent effectively reduces bird consumption of crop seeds, providing significant protection. Even at very low concentrations (2 grams per kilogram of seed), the bird repellent effectively deters common bird species. When used at the recommended dosage, it will not harm birds. It is safe for humans and livestock, easy to use, and low in cost. Furthermore, it promotes the growth and development of crop seeds, seedlings, and fruits, leading to increased agricultural production and higher farmer incomes.

[0057] The above description outlines the basic principles, main features, and performance advantages of this invention. It should be understood that the performance and applications of this invention are not limited to the examples described above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. The application of an amino acid metal complex in the preparation of bird repellents, characterized in that, The application uses bird repellents made from amino acid metal complexes as the active ingredient to treat crop seeds by seed dressing or spraying. The amino acid in the amino acid metal complex is one of glycine, aspartic acid, phenylalanine, methionine, arginine, leucine, isoleucine, lysine, glutamic acid, and alanine. The metal in the amino acid metal complex is one of zinc, manganese, magnesium, iron, copper, and calcium; The birds described are white-rumped munias, spotted doves, domestic chickens, or pheasants; The crop seed is rice; the dosage of the active ingredient is 2 grams per kilogram of rice seed or 4 grams per kilogram of rice seed.

2. The application of a pharmaceutical formulation in the preparation of bird repellents, characterized in that, The pharmaceutical preparation includes the amino acid metal complex as described in claim 1; the application is a bird repellent made with the amino acid metal complex as the active ingredient, used for seed dressing or spraying of crop seeds. The amino acid metal complex accounts for 1%-90% of the weight of the pharmaceutical preparation; The birds described are white-rumped munias, spotted doves, domestic chickens, or pheasants; The crop seed is rice; the dosage of the active ingredient is 2 grams per kilogram of rice seed or 4 grams per kilogram of rice seed.

3. The application of the pharmaceutical preparation according to claim 2 in the preparation of bird repellent, characterized in that, The dosage form of the pharmaceutical preparation is selected from any one of the following: suspension, emulsion, water emulsion, microemulsion, microcapsule suspension, oil suspension, emulsifiable concentrate, soluble concentrate, soluble granules, soluble powder, water-dispersible granules, wettable powder, powder, granules, seed-treated suspension, seed-treated emulsion, seed-treated liquid, seed-treated dispersible powder, and seed-treated dry powder.

4. The application of the pharmaceutical preparation according to claim 2 in the preparation of bird repellent, characterized in that, The amino acid metal complex accounts for 10%-50% of the weight of the pharmaceutical preparation.

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