A traditional Chinese medicine preparation for treating cervical erosion

Abstract

This invention provides a highly effective, broad-spectrum antibacterial, and rapidly repairing traditional Chinese medicine preparation for the treatment of skin and mucous membrane infections. It is formulated from a combination of herbs including snow lotus, buffalo horn, allium macrostemon, poria cocos, reed rhizome, dictamnus dasycarpus bark, Paris polyphylla, chrysanthemum, scutellaria barbata, physalis alkekengi, mulberry bark, and honeysuckle, based on traditional Chinese medicine theory, combined with modern medical research and clinical experience. The selected herbs are pure Chinese herbal medicines with a rational synergistic combination. Applied externally, the medicine acts directly on the affected area, resulting in rapid action. It avoids the gastrointestinal, hepatic, and renal irritation associated with oral preparations, reducing patient discomfort. The treatment course is short, the cost is low, and it is convenient to use. Clinical symptoms disappear rapidly, the efficacy is significant, and it is practical, safe, and free of toxic side effects.

Description

Technical Field

[0001] This invention provides a traditional Chinese medicine preparation for treating cervical erosion, used to treat skin and mucous membrane infections, and also provides a method for preparing the traditional Chinese medicine preparation, belonging to the field of traditional Chinese medicine pharmaceutical technology. Background Technology

[0002] In daily life, for hygiene and safety, people usually use disinfectants to spray disinfectant on the surrounding environment or the human body. However, most disinfectants, especially "84 disinfectant", have particularly strong toxic side effects. Although disinfectant can kill viruses and bacteria during spraying, it can also damage the skin or respiratory mucosa if precautions are not taken. Therefore, the main task of this invention is to provide a preparation that can broadly fight bacteria and quickly repair cell mucosal tissues. Summary of the Invention

[0003] This invention discloses a traditional Chinese medicine preparation for treating cervical erosion and its preparation method, which solves the problems of highly effective sterilization and antiviral action, as well as rapid repair of damaged skin and mucous membranes. It truly achieves the purpose of strengthening the body's resistance and eliminating pathogens, sterilizing and fighting viruses, and establishing the first line of defense for the human body.

[0004] This invention provides a traditional Chinese medicine preparation for treating cervical erosion, which is made from the following raw materials in the following weight ratios:

[0005] Snow lotus 2-20 parts, buffalo horn 3-30 parts, Chinese lantern 3-30 parts, reed rhizome 3-30 parts, allium macrostemon 3-30 parts, honeysuckle 3-30 parts, chrysanthemum 3-30 parts, Paris polyphylla 3-30 parts, Scutellaria barbata 3-30 parts, Bletilla striata 3-30 parts, Poria cocos 3-30 parts, mulberry bark 3-30 parts.

[0006] The preferred ingredients are: 2-5 parts snow lotus, 3-15 parts buffalo horn, 3-15 parts Phyllanthus urinaria, 3-15 parts reed rhizome, 3-15 parts Allium macrostemon, 3-15 parts honeysuckle, 3-15 parts chrysanthemum, 3-15 parts Paris polyphylla, 3-15 parts Scutellaria barbata, 3-15 parts Bletilla striata, 3-15 parts Poria cocos, and 3-15 parts mulberry bark.

[0007] The optimal ingredients are: 2 parts snow lotus, 3 parts buffalo horn, 3 parts Chinese lantern, 3 parts reed rhizome, 3 parts allium macrostemon, 3 parts honeysuckle, 3 parts chrysanthemum, 3 parts Paris polyphylla, 3 parts Scutellaria barbata, 3 parts Bletilla striata, 3 parts Poria cocos, and 3 parts mulberry bark.

[0008] The active ingredients obtained from the raw materials of this invention can be mixed with trace amounts of dialcyldimethylammonium chloride to make an antibacterial solution that can significantly enhance the antibacterial and mucosal repair effects.

[0009] This invention provides a preparation method for treating cervical erosion, comprising the following steps:

[0010] (1) Weigh out the following ingredients in proportion: snow lotus, buffalo horn, allium macrostemon, poria cocos, reed rhizome, datura bark, Paris polyphylla, chrysanthemum, scutellaria barbata, physalis alkekengi, mulberry bark, and honeysuckle.

[0011] (2) The above 12 raw materials were extracted by ultra-low temperature critical carbon dioxide extraction method;

[0012] (3) Add the extracted powder to pharmaceutical distilled water, and then add the enhancer diallyl dimethyl ammonium chloride to make the product.

[0013] The preferred embodiment of the preparation method described in this invention is as follows:

[0014] (1) Take the above 12 Chinese medicinal herbs (snow lotus, buffalo horn, allium macrostemon, poria cocos, reed rhizome, datura bark, Paris polyphylla, chrysanthemum, scutellaria barbata, physalis alkekengi, mulberry bark, honeysuckle) according to the proportions and decoct them 3 times, each time for 2 hours. Combine the decoctions to obtain a thick paste.

[0015] (2) Dry the thick paste under reduced pressure (0.08 MPa, 70-85℃) and pulverize it into a fine powder for later use.

[0016] (3) The obtained fine powder is mixed with pharmaceutical distilled water at 1000-5000% of the weight of the fine powder to make a liquid.

[0017] The most preferred embodiment of the preparation method described in this invention is as follows:

[0018] (1) Weigh 100g of snow lotus and 300g of buffalo horn (the other 10 ingredients are all 300g) according to the proportion, add 8 times the amount of water and decoct 3 times, each time for 2 hours. Filter and combine the filtrates and concentrate to a thick paste (relative density 1.45-1.50.60℃ the next day).

[0019] (2) Dry the thick paste under reduced pressure and pulverize it into a fine powder;

[0020] (3) Mix the obtained fine powder with 1000-5000% of the weight of the fine powder in pharmaceutical distilled water and add 0.02% of dialcyldimethylammonium chloride to prepare 3300.000mL (3300kg) of antibacterial solution.

[0021] [Dosage and administration] 0.5-1 mL 3-5 times / day.

[0022] [Indications] Cervical erosion.

[0023] The pharmacological and efficacy formula of this invention is explained as follows: Principal herbs: The principal herbs of this invention are snow lotus and buffalo horn. Modern research has found that snow lotus has significant effects on beauty and skin care, especially in anti-oxidation and anti-aging, and can improve the body's overall metabolic function, but it is slightly insufficient in antibacterial and anti-inflammatory effects. Assistant herbs: Physalis alkekengi, reed rhizome, Paris polyphylla, and honeysuckle are selected as assistant herbs. Honeysuckle is a well-known antibacterial and anti-inflammatory drug. Physalis alkekengi is being used for the first time in a skin antibacterial solution. It has unique effects in antibacterial and anti-inflammatory treatments, especially in treating acute and chronic pharyngitis. Its use in skin antibacterial solutions has the characteristics of a wide range of effects and no side effects. Paris polyphylla is a traditional Chinese medicine with strong antibacterial and anti-inflammatory properties. Reed rhizome, according to traditional Chinese medicine theory, has the effects of nourishing yin, clearing deficiency heat, and detoxifying. This invention utilizes a powerful combination of four herbs. The therapeutic effect is further enhanced when combined with honeysuckle. The adjuvant herbs—Allium macrostemon, Scutellaria barbata, Chrysanthemum morifolium, and Bletilla striata—are used to treat concurrent symptoms or to enhance the efficacy of the principal and auxiliary herbs, creating favorable conditions for their combined effects. Allium macrostemon is generally considered to have a warming and invigorating effect on the heart yang. This invention is used for various skin infections caused by obstruction, stagnation, and insufficient chest yang, and it also accelerates wound healing. The guiding herbs—Bletilla striata, Poria cocos, and Morus alba root bark—guide the medicinal power directly to the affected area (skin), creating favorable conditions for the principal and auxiliary herbs to exert their effects more effectively. The use of tree bark to treat skin is a concrete manifestation and application of the analogy and analogy method in traditional Chinese medicine.

[0024] The formulation of this invention combines buffalo horn, Physalis alkekengi, and Allium macrostemon for skin antibacterial effects, achieving unexpected therapeutic results. Using trace amounts of dialcyldimethylammonium chloride (0.01-0.03%) as an enhancer for the 12 traditional Chinese medicines significantly increases the efficacy of the trace medicinal components in the skin antibacterial solution.

[0025] This invention has significant therapeutic effects on the following diseases:

[0026] Skin diseases: 1. Bedsores 2. Herpes zoster 3. Diabetic foot 4. Burns (burns below degree II do not need to be sent to a sterile ward; use the treatment immediately to prevent scarring) 5. Severe, chronic oral ulcers 6. Wounds and fistulas that are slow to heal

[0027] Gynecology: 1. Pelvic inflammatory disease 2. Grade III cervical erosion (the cure rate for the above two diseases within 1 month is over 87.5%) 3. High-risk HPV cervical cancer positive (the conversion rate to negative within 3 months is over 85%).

[0028] In this invention's formula, three traditional Chinese medicines—Physalis alkekengi, buffalo horn, and Allium macrostemon—are used for the first time in traditional Chinese medicine dermatology and gynecology. The formula utilizes dialc-dimethylammonium chloride in combination with other drugs, resulting in new medicinal effects and efficacy, curing many diseases that are difficult to treat with both traditional Chinese and Western medicine. Traditionally, dialc-dimethylammonium chloride is used as a skin disinfectant at a dosage of 0.3%, but this invention provides its optimal concentration ratio and combination of traditional Chinese medicines. The concentration of dialc-dimethylammonium chloride is below 0.02%, and the total content of traditional Chinese medicines is below 0.01%, resulting in significant medicinal effects and efficacy, curing many diseases that are difficult to treat with both traditional Chinese and Western medicine. The cure rate is over 90%. For example, ulcers, shingles, and burns (second-degree burns and scalds do not require admission to a sterile ward) can be cured with this medication in a regular ward, leaving no scars. More importantly, hair can grow back at the burn site, whereas other treatments, even if they heal the burn, will leave scars and prevent hair follicles from forming (the skin in that area cannot breathe). The same applies to diabetic foot.

[0029] The drug of this invention can be used to treat pelvic inflammatory disease and grade III cervical erosion, which can generally be cured within one month; it can also achieve negative HPV results in high-risk groups for cervical cancer. Currently available imported HPV vaccines are 9-valent. High-risk groups are identified by 17 subtypes of HPV (17+). The drug of this invention is a broad-spectrum anti-HPV drug effective against all high-risk cervical cancer types, and the negative conversion rate within 3 months can reach as high as 85%.

[0030] The positive effects of this invention are as follows:

[0031] This product is developed based on traditional Chinese medicine theory, combined with modern medical research findings and clinical experience in TCM. The selected medications are pure Chinese herbal medicines, with a rationally synergistic formula. Administered externally, the medicine acts directly on the affected area, resulting in rapid action. It avoids the irritation to the gastrointestinal tract, liver, and kidneys caused by oral preparations, reducing patient discomfort. The treatment course is short, the cost is low, and it is convenient to use. Clinical symptoms of cervical erosion disappear rapidly, demonstrating significant efficacy. It is practical, convenient, safe, and has no toxic side effects. Attached Figure Description

[0032] Figure 1 These are before-and-after photos of the treatment effects in Case 1 of this invention;

[0033] Figure 2 These are before-and-after photos of the treatment effects in Case 2 of this invention;

[0034] Figure 3 These are before-and-after photos of the treatment effects in Case 3 of this invention;

[0035] Figure 4 These are before-and-after photos of the treatment effects in Case 4 of this invention;

[0036] Figure 5 . Figure 6These are before-and-after photos of the treatment effects in Case 5 of this invention. Detailed Implementation

[0037] The present invention is further illustrated by the following embodiments, which are not intended to limit the invention in any way. Any modifications or alterations made to the present invention that are easily implemented by those skilled in the art without departing from the technical solutions of the present invention shall fall within the scope of the claims of the present invention. Example 1

[0038] (1) Weigh out 100g of snow lotus, 100g of buffalo horn, 150g of Chinese lantern, 150g of reed rhizome, 150g of allium macrostemon, 150g of honeysuckle, 150g of chrysanthemum, 150g of Paris polyphylla, 150g of Scutellaria barbata, 150g of Bletilla striata, 150g of Poria cocos, and 150g of mulberry bark according to the proportions;

[0039] (2) The above 12 raw materials were extracted by ultra-low temperature critical carbon dioxide extraction method;

[0040] (3) Add the extracted powder from step 2) to pharmaceutical distilled water, and then add 0.02% of the enhancer didecyl dimethyl ammonium chloride to obtain the final product. Example 2

[0041] (1) Take the following ingredients in proportion: 200g of snow lotus, 300g of buffalo horn, 300g of Phyllanthus urinaria, 300g of reed rhizome, 300g of Allium macrostemon, 300g of honeysuckle, 300g of chrysanthemum, 300g of Paris polyphylla, 300g of Scutellaria barbata, 300g of Bletilla striata, 300g of Poria cocos, and 300g of mulberry bark. Boil them three times, each time for 2 hours, and combine the decoctions to obtain a thick paste.

[0042] (2) Dry the thick paste under reduced pressure at 0.08 MPa and 70-85℃ and pulverize it into a fine powder;

[0043] (3) The fine powder obtained in step 2) is prepared by mixing with pharmaceutical distilled water at a weight of 1000-5000% of the fine powder. Example 3

[0044] (1) Weigh 100g of snow lotus and 300g of buffalo horn according to the proportion, weigh 300g of the other 10 ingredients, add 8 times the amount of water and decoct 3 times, each time for 2 hours, filter and combine the filtrates and concentrate to a thick paste with a relative density of 1.45-1.50.60℃ the next day;

[0045] (2) Dry the thick paste under reduced pressure and pulverize it into a fine powder;

[0046] (3) The fine powder obtained in step 2) is mixed with 1000-5000% of the weight of pharmaceutical distilled water and 0.02% of dialcyldimethylammonium chloride is added to prepare 3300.000 mL (3300 kg) of antibacterial solution.

[0047] The positive effects of this invention will be further illustrated below with clinical examples:

[0048] Clinical observation of the efficacy of traditional Chinese medicine in treating cervical erosion in 80 cases

[0049] 1. Clinical Data

[0050] 1.1 Study Subjects: Eighty patients with large areas of cervical erosion who received treatment in a gynecological clinical treatment study jointly conducted by the Institute and Outpatient Department of this Invention from May 2018 to August 2020 were selected. All patients had given birth before and were aged between 25 and 50 years old. Of the 80 patients, 40 in the treatment group received traditional Chinese medicine treatment, while the other 40 in the control group received conventional treatment. The diagnostic and efficacy criteria were consistent between the two groups. Of the 80 patients, 74 were outpatients and 26 were inpatients. Their ages ranged from 25 to 50 years, with 6 under 35 years old, 44 between 35 and 40 years old, 23 between 40 and 45 years old, and 7 over 45 years old. The duration of disease was 2-3 years in 53 cases, 4-6 years in 16 cases, 7-10 years in 8 cases, and over 10 years in 3 cases. There were no significant differences in age or duration of disease between the two groups, making them comparable. All 80 patients were willing to receive traditional Chinese medicine treatment.

[0051] 1.2 Diagnostic Criteria The main clinical manifestation of cervical erosion is increased vaginal discharge. Due to different pathogens, the color of the discharge varies; some are milky white and mucous, while others are pale yellow, purulent, or bloody, with milky white and mucous discharge being the most common. In addition to increased discharge, patients may experience lower back pain and bleeding after intercourse. The cause is mostly due to cervical damage during sexual intercourse or childbirth, leading to bacterial invasion. It can also be caused by a weak constitution or bacterial infection during menstruation. Currently, gynecological examination is the main diagnostic method for cervical erosion. It is generally divided into three types: ① Simple type: The columnar epithelium on the erosion surface grows flat and smooth. Symptoms are relatively mild; ② Papillary type: Significant abnormal stromal hyperplasia, making the surface more uneven and papillary; symptoms are obvious; ③ Granular type: Excessive proliferation of glandular epithelium, accompanied by stromal hyperplasia, making the surface uneven and granular. Symptoms may lessen or disappear after treatment.

[0052] 2 Methods

[0053] 2.1 Treatment methods: (1) The control group of 40 cases received routine physical treatment, using a medical electrocautery device to burn the eroded tissue to cause necrosis and sloughing; (2) The treatment group received the external application of the traditional Chinese medicine preparation of this invention, 5ml vaginally each time, with a 5-day rest period after each 5-day course of treatment, one month as a course of treatment, 18 doses per month, and discontinued during menstruation. Treatment principle: Clearing heat and detoxifying, promoting diuresis.

[0054] 2.2 Statistical Methods The χ² test was used for statistical analysis in this study.

[0055] 3 Results

[0056] (1) The cure rate in the control group was 0 (0%), the significant effect rate was 16 (40%), the effective rate was 15 (38%), and the ineffective rate was 9 (22%).

[0057] (2) In the treatment group, 35 cases (87.5%) were cured, 3 cases (7.5%) showed significant improvement, and 2 cases (5%) were ineffective. The traditional Chinese medicine preparation of this invention has a high cure rate in the treatment of cervical erosion.

[0058] Table 1 Comparison of cure rates between the treatment group and the control group

[0059]

[0060] Note: The cure rate and efficacy rate of the treatment group were significantly better than those of the control group according to the χ2 test, and the difference was statistically significant.

[0061] in conclusion:

[0062] Cervical erosion is a common gynecological disease, often resulting from incomplete treatment of acute cervicitis. The course of the disease can last for decades. Despite long-term drug treatment, most patients with cervical erosion do not see improvement, and the effects are poor. This seriously affects the patient's physical and mental health, work, and life.

[0063] Case 1:

[0064] A 56-year-old male went to the hospital in November 2022. There was a gouty tophi about 3 cm x 3 cm in size on the first metacarpophalangeal joint of his hand. Three months after the surgical removal, the wound had not closed and was painful. Anti-inflammatory injections were ineffective.

[0065] Treatment: Apply the solution of this invention to the wound 3-4 times daily, 0.5 mL per application. The wound will begin to shrink after one week of use and will heal completely in about one month (see [link]). Figure 1 ).

[0066] Case 2:

[0067] A 1.5-year-old child was found to have a large area of ​​red infantile eczema on his thighs and groin in a certain month of a certain year. The eczema was 2 mm thick. The child was crying and restless. Treatment with Fujining ointment and other medications was ineffective.

[0068] Treatment: The medicated solution of this invention is effective on the same day of application, with significant improvement within 3 days and complete recovery within 6 days. Several months later, red rashes reappeared on the legs and feet. A pediatric examination at the hospital diagnosed it as hand-foot-and-mouth disease (atypical). The hospital recommended anti-inflammatory medication, which the parents did not accept. Without using any other medications, the antibacterial medicated solution of this invention was used, spraying the affected area 4-5 times daily (approximately 1 ml each time). Recovery occurred in about ten days (see [link to treatment]). Figure 2 ).

[0069] Case 3:

[0070] A 65-year-old man, who had been diagnosed with diabetes for 8 years, injected 50 units of insulin daily, yet his pre-meal blood sugar remained around 16. At the beginning of the year, the skin on both lower legs turned black, particularly the outer side of his left lower leg, and began to ulcerate. Treatment with various Chinese and Western medicines at the endocrinology department of a top-tier hospital was ineffective and his condition seemed to be worsening.

[0071] Treatment: Spray the medicated solution of this invention onto the affected area of ​​the lower leg 4-5 times daily, 1-2 mL each time. The ulcerated skin will begin to improve after about a week. Continue using the medication for about a month, and the ulceration will show significant improvement. After about two months of treatment, the ulceration will scab over and heal (see...). Figure 3 ).

[0072] Case 4:

[0073] A 67-year-old male was diagnosed with allergic dermatitis at the hospital. He has a history of long-term exposure to chemical raw materials. Over the past 15 years, his dermatitis on his lower legs has worsened, with unbearable itching and multiple subcutaneous nodules. Various treatments have been ineffective.

[0074] Treatment: Use this antibacterial solution, 1 mL each time, 3-4 times daily. After one month of treatment, the itching will subside and the subcutaneous nodules will disappear (see...). Figure 4 ).

[0075] Case 5:

[0076] A 61-year-old man, who had suffered from diabetes for decades, experienced blurred vision and diabetic retinopathy. He burned his feet while washing them with hot water, resulting in ulcers on the soles of his feet that failed to heal for a long time due to the insensitivity of his feet to temperature.

[0077] Treatment: Use this antibacterial solution at 1.5 ml / time, 4 times / day. After about 3 months of treatment, the ulceration will heal (see...). Figure 5 , Figure 6 ).

[0078] Case 6:

[0079] A 59-year-old woman experienced frequent lower back pain and increased vaginal discharge, sometimes with an unpleasant odor, after giving birth. After gynecological examinations including ultrasound, she was diagnosed with pelvic inflammatory disease accompanied by pelvic effusion (approximately 15 mL). Various treatments proved ineffective.

[0080] Treatment: Administer 5 mL of the medication solution of this invention vaginally using a gynecological applicator. Use for 3 days, rest for 2 days, then repeat the treatment. Use 18 applicators per month, completing one course of treatment per month. After one month of treatment, a large amount of discharge is expelled from the vagina. After three months of continuous treatment, the lower back pain symptoms disappear, the vaginal discharge returns to normal, and an ultrasound examination shows the pelvic effusion has disappeared.

[0081] Case 7:

[0082] A 31-year-old woman presented with dysmenorrhea and abnormal vaginal discharge. Examination revealed grade 2 cervical erosion and HPV 16 and 18 positivity. The hospital recommended conization, but she disagreed with the treatment. She was treated with the gynecological type of the antibacterial agent of this invention, 5 mL once daily, with a 3-day treatment followed by a 2-day rest period, for a total of 18 treatments per month. After one month of treatment, a gynecological examination showed that her cervix had returned to normal, and her dysmenorrhea had significantly decreased. She continued treatment according to the original plan, and after another month, her HPV test came back negative.

[0083] Case 8:

[0084] A 54-year-old woman tested positive for HPV

[27] typology (HPV-DNA type 59). Her cervix was not smooth upon gynecological examination. She received interferon injections of 3 million units and topical gynecological medications for one year at the hospital, but the treatment was ineffective.

[0085] Treatment: Administer 5 ml of the drug solution of this invention vaginally using a gynecological applicator. Use the drug for 3 days, rest for 2 days, and then administer the drug again. Use 18 doses per month, and complete one course of treatment in 3 months. Do not use any other medications during the course of treatment. After 3 months of treatment, rest for half a month and then have a follow-up HPV test to confirm that all positive results have turned negative.

Claims

1. A traditional Chinese medicine preparation for treating cervical erosion, characterized in that: Made from the following raw materials in parts by weight: Snow lotus 2-20 parts, buffalo horn 3-30 parts, Chinese lantern 3-30 parts, reed rhizome 3-30 parts, allium macrostemon 3-30 parts, honeysuckle 3-30 parts, chrysanthemum 3-30 parts, Paris polyphylla 3-30 parts, Scutellaria barbata 3-30 parts, Bletilla striata 3-30 parts, Poria cocos 3-30 parts, mulberry bark 3-30 parts.

2. The traditional Chinese medicine preparation for treating cervical erosion as described in claim 1, characterized in that: Made from the following raw materials in parts by weight: Snow lotus 2-5 parts, buffalo horn 3-15 parts, Chinese lantern 3-15 parts, reed rhizome 3-15 parts, allium macrostemon 3-15 parts, honeysuckle 3-15 parts, chrysanthemum 3-15 parts, Paris polyphylla 3-15 parts, Scutellaria barbata 3-15 parts, Bletilla striata 3-15 parts, Poria cocos 3-15 parts, mulberry bark 3-15 parts.

3. A traditional Chinese medicine preparation for treating cervical erosion as described in claim 1, characterized in that... Made from the following raw materials in parts by weight: 2 parts snow lotus, 3 parts water buffalo horn, 3 parts Chinese lantern, 3 parts reed rhizome, 3 parts allium macrostemon, 3 parts honeysuckle, 3 parts chrysanthemum, 3 parts Paris polyphylla, 3 parts Scutellaria barbata, 3 parts Bletilla striata, 3 parts Poria cocos, 3 parts mulberry bark.

4. A method for preparing a traditional Chinese medicine preparation for treating cervical erosion as described in any one of claims 1 to 3, characterized in that... Includes the following steps: (1) Weigh out the following ingredients in proportion: snow lotus, buffalo horn, allium macrostemon, poria cocos, reed rhizome, datura bark, Paris polyphylla, chrysanthemum, scutellaria barbata, physalis alkekengi, mulberry bark, and honeysuckle. (2) The above 12 raw materials were extracted by ultra-low temperature critical carbon dioxide extraction method; (3) Add the extracted powder from step 2) to pharmaceutical distilled water, and then add 0.02% of the enhancer diallyl dimethyl ammonium chloride to obtain the final product.

5. A method for preparing a traditional Chinese medicine preparation for treating cervical erosion as described in any one of claims 1 to 3, characterized in that... Includes the following steps: (1) Take snow lotus, buffalo horn, allium macrostemon, poria cocos, reed rhizome, datura bark, Paris polyphylla, chrysanthemum, scutellaria barbata, physalis alkekengi, mulberry bark, and honeysuckle in proportion, decoct 3 times, 2 hours each time, and combine the decoctions to obtain a thick paste; (2) Dry the thick paste under reduced pressure at 0.08 MPa and 70-85℃ and pulverize it into a fine powder; (3) The fine powder obtained in step 2) is prepared by mixing with pharmaceutical distilled water at a weight of 1000-5000% of the fine powder.

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