Traditional Chinese medicine for treating anorexia in children, external application plaster and preparation method

Abstract

The application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating infantile anorexia, a topical plaster and a preparation method. The traditional Chinese medicine is prepared by combining clove, amomum villosum, fried atractylodes, fried atractylodes rhizome, costus, zedoary, radish seed and borneol with corresponding auxiliary materials. In the prescription, clove is the monarch, which can warm yang and supplement fire and warm earth; amomum villosum, atractylodes and atractylodes rhizome are the ministers, which can invigorate the spleen and eliminate dampness, assist the monarch in warming the spleen yang and eliminating dampness and ascending clear; costus, radish seed and zedoary are the aids, which can invigorate the spleen and digest food, and can lower the stomach and eliminate stagnation; borneol is slightly bitter and cold, which can open the orifices, awaken the spirit, clear heat and relieve pain, and the dispersing and diffusing function of borneol can lead the other medicines to the heart and abdomen, and disperse the orifices, and borneol is the ministerial medicine. The combination of the medicines can achieve good effects.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine for treating infantile anorexia, an external use plaster and a preparation method. BACKGROUND

[0002] Infantile anorexia is a common disease of the spleen and stomach in children, and is characterized by long-term aversion to food and reduced food intake. If anorexia is not improved for a long time, it can cause a series of symptoms such as growth and development retardation, low immunity, repeated infection and other diseases in children, and become a high-risk factor for the occurrence and development of other diseases, and seriously affect the growth and development of children.

[0003] The understanding of infantile anorexia in traditional Chinese medicine has a long history, and it is believed that infantile anorexia is usually caused by congenital deficiency, weak spleen and stomach, improper feeding, damage to the spleen and stomach, emotional disorder, liver qi stagnation, invasion of the spleen and stomach, and spleen deficiency. According to the standard of TCM syndrome differentiation, the infantile anorexia can be divided into spleen-stomach disharmony syndrome, spleen-stomach dampness-heat syndrome, spleen-stomach qi deficiency syndrome, spleen-stomach yin deficiency syndrome, and liver-stomach deficiency syndrome. The treatment of infantile anorexia by traditional Chinese medicine focuses on the whole body, syndrome differentiation and treatment, and follows the basic principle of "spleen health is not in operation, and supplement is important in operation". In order to avoid the disease from being prolonged, the intake of water and food essence is insufficient, and the qi and blood cannot be produced, which causes the growth and development of children to be retarded, the whole body to be emaciated, and even the intelligence development of children to be affected.

[0004] In the treatment of infantile anorexia, the compliance of children is poor when taking traditional Chinese medicine orally, therefore, the present application provides a traditional Chinese medicine for treating infantile anorexia by external use. Although there are some plaster ointments for treating infantile spleen and stomach diseases by external use at present, such as compound clove appetite stimulating plaster, Dinggui infantile umbilical plaster and intestinal and stomach powder. However, the above-mentioned drugs are mainly used for short-term spleen and stomach diseases. In comparison, the traditional Chinese medicine of the present application is particularly suitable for children with long-term loss of appetite and anorexia, and has the characteristics of exact curative effect, no side effect and excellent curative effect. The traditional Chinese medicine of the present application has the advantages of traditional Chinese medicine, and has important significance for preventing and treating infantile anorexia and maintaining the health of children. SUMMARY

[0005] The present application aims to achieve the purposes of invigorating the spleen and stomach and promoting blood circulation and regulating qi by the dual effects of drugs and acupoints. In addition, in view of the difficulty of oral administration of drugs for children, the acupoint plaster suitable for children is specially prepared to be applied to the corresponding acupoints. Therefore, the present application provides a traditional Chinese medicine external use plaster for treating infantile anorexia and a preparation process. The prescription is prepared by our hospital, and the pure traditional Chinese medicine formula has been observed to have good curative effect in clinical observation for many years. The traditional Chinese medicine external use plaster for treating infantile anorexia has exact curative effect, no side effect and good compliance of children.

[0006] This invention is specifically designed for children with long-term loss of appetite, anorexia, and picky eating, which are often accompanied by qi stagnation and blood stasis. It adds turmeric to promote blood circulation and remove blood stasis; stir-fried radish seeds, costus root, and amomum villosum are added to strengthen the spleen and regulate qi. This combination strengthens the spleen and stomach while regulating qi and dispersing blood stasis, achieving the goal of treating both the symptoms and the root cause.

[0007] The effects of each medicinal ingredient in this invention are as follows:

[0008] Cloves – warm the middle burner, relieve nausea and vomiting, promote qi circulation, relieve pain, and refresh the mind.

[0009] Amomum villosum – dispels dampness, stimulates appetite, warms the spleen, stops diarrhea, regulates qi, and calms the fetus;

[0010] Stir-fried Atractylodes macrocephala – strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and calms the fetus;

[0011] Stir-fried Atractylodes lancea – dries dampness, strengthens the spleen, dispels wind and cold, and improves eyesight;

[0012] Costus root – warms the middle jiao, promotes qi circulation, relieves pain, strengthens the spleen, aids digestion, and relieves stagnation;

[0013] Curcuma zedoaria – breaks up blood stasis, promotes qi circulation, eliminates stagnation, and relieves pain;

[0014] Radish seeds – aid digestion, relieve bloating, regulate qi, and resolve phlegm;

[0015] Borneol – It awakens the mind, clears heat and relieves pain, and has a fragrant and penetrating effect.

[0016] This formula uses cloves as the chief ingredient. Cloves are pungent and warm in nature, and their functions include warming the middle jiao (spleen and stomach), relieving nausea and vomiting, tonifying the kidneys and assisting yang. The *Yilin Zuanyao* states that cloves "tonify the liver, moisten the gate of life, warm the stomach, and dispel cold in the middle jiao." They can warm the middle jiao yang and tonify fire and warm the earth element. This single herb can assist both prenatal and postnatal yang, treating the disease from the perspective of the root causes of both, hence its status as the chief ingredient. The middle jiao is deficient and cold, the spleen is weak and unable to transport and transform fluids, resulting in the inability of body fluids to ascend and clear, leading to water retention. Therefore, while treating the root cause, it is necessary to supplement with spleen-strengthening and dampness-removing herbs. Amomum villosum and Atractylodes lancea are the assistant ingredients. These three herbs, while strengthening the spleen, can also remove dampness, assisting the chief ingredient in warming and transporting spleen yang, promoting the upward movement of clear fluids, and restoring the spleen's normal ascending function. When the spleen and stomach functions are abnormal, and the spleen fails to ascend clear fluids, the stomach will also fail to descend properly. If the stomach qi fails to descend, food will stagnate in the stomach and intestines, resulting in food stagnation. Therefore, the formula uses Aucklandia lappa, Radish seed, and Curcuma zedoaria as assistant ingredients to strengthen the spleen and promote digestion. Costus root and radish seed are pungent and warm, promoting qi circulation and aiding digestion, effectively reducing stomach stagnation. Curcuma zedoaria, according to the *Ben Cao Jing Shu*, is "pungent and strong, specifically targeting the blood in the qi, mainly breaking up accumulations and dissolving hard masses." While clearing food stagnation in the stomach and intestines, it also promotes qi and blood circulation, helping to restore the normal ascending and descending functions of the spleen and stomach. Borneol is pungent, bitter, and slightly cold. Its functions include opening the orifices, refreshing the mind, clearing heat, and relieving pain. The *Tang Ben Cao* states that it "treats evil qi in the heart and abdomen, and wind-dampness accumulation." Its pungent and dispersing power can guide other herbs to the heart and abdomen, dispersing through the orifices, thus acting as a guiding herb. The entire formula works to warm and invigorate the spleen and stomach, tonify the kidneys and assist yang, resolve dampness and promote clear qi, strengthen the spleen and eliminate stagnation, and promote qi circulation and relieve pain. It promotes qi circulation, resolves dampness and eliminates stagnation without harming the body's vital energy, strengthening both prenatal and postnatal constitution, deeply understanding the wonders of yin and yang.

[0017] The object of the present application is achieved by the following technical solutions.

[0018] A traditional Chinese medicine for treating anorexia in children, characterized in that the traditional Chinese medicine raw materials are proportioned by weight as follows: clove 1-20 parts, amomum 1-20 parts, fried atractylodes 1-20 parts, fried atractylodes 1-20 parts, safflower 1-20 parts, zedoary 1-20 parts, raphanus 1-20 parts, and borneol 0.5-10 parts.

[0019] The auxiliary materials are combined: nitrogen ketone, edible vinegar, sodium benzoate, and breathable adhesive to form an external application plaster. The above-mentioned traditional Chinese medicine raw materials are ground into powder, uniformly mixed in proportion, and the amount of auxiliary materials is: 0.5 parts of nitrogen ketone, an appropriate amount of edible vinegar, and 0.05 parts of sodium benzoate for every 1 part of mixed traditional Chinese medicine powder.

[0020] The use method is: external application to the navel. Specifically: the pills are placed in the navel (Shenque point), and a breathable adhesive is applied, with a duration of 4-8 hours per day, and a course of 7 days.

[0021] Precautions: 1. This product is for external use and is prohibited for internal use. 2. The application site should not be used if there is skin damage, itching, redness, etc. If the symptoms do not improve after applying the medicine, please seek medical attention promptly. 3. This product is an external auxiliary medicine. If the symptoms do not improve after a course of treatment, please seek medical attention promptly. 4. Please store it in a place where children cannot easily access. Children should use it under the supervision of their parents. 5. It should be used with caution by people who are allergic to medicines or application.

[0022] The traditional Chinese medicine for treating anorexia in children preferably includes: clove 5-10 parts, amomum 3-6 parts, fried atractylodes 1-5 parts, fried atractylodes 1-5 parts, safflower 3-6 parts, zedoary 1-5 parts, raphanus 1-5 parts, and borneol 0.5-5 parts.

[0023] Further, it can include: clove 1 part, amomum 1 part, fried atractylodes 1 part, fried atractylodes 1 part, safflower 1 part, zedoary 1 part, raphanus 1 part, and borneol 0.5 part.

[0024] The preparation method of the traditional Chinese medicine for treating anorexia in children includes the following steps: grinding the relevant medicines into powder, uniformly mixing them in proportion, and adding nitrogen ketone, edible vinegar, sodium benzoate, and breathable adhesive to form an external application plaster.

[0025] This scheme is based on the traditional Chinese medicine principle of treating internal diseases externally, and provides an external plaster with fast effect, high efficacy, no side effects, and high acceptance. The selected drugs have no toxic side effects, and the active ingredients of the drugs can be rapidly released and quickly absorbed by the skin, directly reaching the lesion to play a therapeutic role. It has a faster onset and longer-lasting effect than conventional oral administration, and does not cause adverse reactions to the stomach, liver, and kidneys. The application is applied to the navel, which is a human health acupoint. This product treats the disease in a comprehensive manner, improves appetite by invigorating the spleen and regulating qi, and fundamentally regulates and improves gastrointestinal function.

[0026] To illustrate the therapeutic effect of the present application, the following experiments were conducted. The treatment group is the present application, Comparative Example 1 is a commercially available compound fennel appetizing paste (medicinal ingredients: clove, atractylodes, atractylodes, cardamom, amomum, safflower, borneol), Comparative Example 2 is a scheme in which the present application is replaced by radix coptidis in the present application, and Comparative Example 3 is a scheme in which curcuma zedoaria is replaced by sparganium stoloniferum in the present application. 120 cases of children with anorexia in children's outpatient department of a hospital for 3 years, before treatment, there was no significant difference in the diagnosis of abdominal distension, abdominal pain, abdominal rumbling, nausea and vomiting, mouth and mouth, loss of appetite in 6 aspects of children in each group, according to the random number table method, 4 groups of 30 cases each, 4 groups are: treatment group, comparative example 1-3 group. Table 1 is the improvement results of abdominal distension, abdominal pain, abdominal rumbling, nausea and vomiting, mouth and mouth, loss of appetite in each group after 2 weeks of treatment.

[0027] Table 1:

[0028]

[0029]

[0030] As can be seen from Table 1, the treatment group and Comparative Examples 1-3 have improvement effect on pediatric anorexia in terms of abdominal distension, abdominal pain, abdominal rumbling, nausea and vomiting, mouth and mouth, loss of appetite, etc. The results show that the treatment group and Comparative Examples 1-3 show more excellent effect on each indication. Comparative Examples 2 and 3 screen the adjuvant in the prescription, and after comparing the curative effect, the adjuvant of radix coptidis and radix coptidis is selected as the scheme of the present application.

[0031] Typical case:

[0032] Male child, 6 years old.

[0033] Initial diagnosis: loss of appetite and loss of appetite for more than 2 months. The child began to have poor appetite 2 months ago, loss of appetite, fatigue, mouth and mouth, abdominal distension and abdominal rumbling after eating, accompanied by nausea, occasional abdominal pain, normal urination, and loose stool. Physical examination: no enlargement of bilateral tonsils, no abnormalities in heart and lung examination, no tenderness and rebound tenderness in abdomen, tympany, intestinal sound, pale face, pale tongue, white and greasy fur, and slippery pulse.

[0034] Diagnosis: anorexia.

[0035] Principle: warming and moving the spleen and stomach, tonifying the kidney and assisting yang, removing dampness and ascending clear, invigorating the spleen and eliminating accumulation, and promoting qi and relieving pain.

[0036] Prescription: clove 9 parts, amomum 6 parts, fried atractylodes 5 parts, fried atractylodes 5 parts, safflower 5 parts, curcuma zedoaria 3 parts, radix coptidis 3 parts, borneol 1 part, external use for umbilical application for one week.

[0037] Second visit: the child's appetite improved significantly, the mouth is slightly sticky, bitter, abdominal distension improved, slightly dripping stool, no nausea, pale tongue, thin white fur.

[0038] Prescription: clove 9 parts, 5 parts of amomum, fried atractylodes 5 parts, fried 5 parts of atractylodes, 1 part of costus, 1 part of zedoary, 1 part of radish, 1 part of borneol, external use for one week.

[0039] Third visit: abdominal distension, abdominal pain, abdominal rumbling, all symptoms disappeared, formed stool, increased appetite. Combined with the diet and living habits to consolidate the curative effect. Specific embodiments

[0040] Example 1

[0041] A kind of traditional Chinese medicine for treating anorexia in children, the traditional Chinese medicine raw material is proportioned by weight as follows: clove 1-20 parts, 1-20 parts of amomum, fried atractylodes 1-20 parts, fried 1-20 parts of atractylodes, 1-20 parts of costus, 1-20 parts of zedoary, 1-20 parts of radish, 0.5-10 parts of borneol.

[0042] Example 2

[0043] A kind of traditional Chinese medicine for treating anorexia in children, the traditional Chinese medicine raw material is proportioned by weight as follows: clove 5-10 parts, 3-6 parts of amomum, fried atractylodes 1-5 parts, fried 1-5 parts of atractylodes, 3-6 parts of costus, 1-5 parts of zedoary, 1-5 parts of radish, 0.5-5 parts of borneol.

[0044] Example 3

[0045] A kind of traditional Chinese medicine for treating anorexia in children, the traditional Chinese medicine raw material is proportioned by weight as follows: further can be, clove 1 part, 1 part of amomum, fried atractylodes 1 part, fried 1 part of atractylodes, 1 part of costus, 1 part of zedoary, 1 part of radish, 0.5 parts of borneol.

Claims

1. A traditional Chinese medicine for treating anorexia in children, wherein the raw materials of the traditional Chinese medicine are proportioned by weight as follows: clove 1-20 parts, amomum 1-20 parts, fried atractylodes 1-20 parts, fried rhizoma atractylodis 1-20 parts, saussurea 1-20 parts, zedoary 1-20 parts, raphanus 1-20 parts, and borneol 0.5-10 parts; the raw materials of the traditional Chinese medicine are ground into powder, and mixed uniformly in proportion: 1 part of the mixed traditional Chinese medicine powder is mixed with 0.5 part of nitroglycerin, 0.05 part of sodium benzoate, and an appropriate amount of edible vinegar, and then applied to a breathable adhesive plaster to form an external application plaster.

2. The traditional Chinese medicine for treating anorexia in children according to claim 1, wherein the raw materials of the traditional Chinese medicine are proportioned by weight as follows: clove 5-10 parts, amomum 3-6 parts, fried atractylodes 1-5 parts, fried rhizoma atractylodis 1-5 parts, saussurea 3-6 parts, zedoary 1-5 parts, raphanus 1-5 parts, and borneol 0.5-5 parts.

3. The traditional Chinese medicine for treating anorexia in children according to claim 2, wherein the raw materials of the traditional Chinese medicine are proportioned by weight as follows: clove 1 part, amomum 1 part, fried atractylodes 1 part, fried rhizoma atractylodis 1 part, saussurea 1 part, zedoary 1 part, raphanus 1 part, and borneol 0.5 part; the raw materials of the traditional Chinese medicine are ground into powder, and mixed uniformly in proportion, and the amount of the auxiliary material is as follows: 1 part of the mixed traditional Chinese medicine powder is mixed with 0.5 part of nitroglycerin, 0.05 part of sodium benzoate, and an appropriate amount of edible vinegar, and then applied to a breathable adhesive plaster to form an external application plaster.

4. The preparation method of the traditional Chinese medicine for treating infantile anorexia according to any one of claims 1-3, characterized in that, ​

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