Traditional Chinese medicine oral liquid for enlivening spleen and treating anorexia and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine oral liquid for enlivening spleen and treating anorexia and a preparation method thereof. The traditional Chinese medicine oral liquid comprises raw material medicines, a sweetening agent, an isotonic agent and water, the raw material medicines comprise the following components in parts by weight: 2-3 parts of haws, 2-3 parts of radix puerariae and 1-2 parts of roses; the sweetening agent is honey, xylitol and maltitol. Honey is replaced with the specific sweetening agent, sweet greasy feeling caused by the honey is avoided, meanwhile, oral osmotic pressure balance is adjusted in cooperation with the isotonic agent, the taste is remarkably improved, and the acceptability of a patient is higher; meanwhile, the sweetening agent has a good stabilizing effect on flavonoid active ingredients, degradation of the active ingredients is avoided, and the prepared oral liquid is longer in storage life.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and provides a traditional Chinese medicine oral liquid for invigorating the spleen and treating anorexia, as well as its preparation method. Background Technology

[0002] Traditional Chinese medicine considers the spleen and stomach to be the "foundation of acquired constitution," responsible for transporting and transforming food and absorbing nutrients. If the spleen and stomach are dysfunctional (such as spleen deficiency or dampness affecting the spleen and stomach), symptoms such as loss of appetite, abdominal distension, and fatigue may occur, but there is usually no psychological motivation to actively diet. These symptoms can be improved through Chinese medicine and dietary regulation.

[0003] Chinese invention patent CN1943654B discloses a traditional Chinese medicine composition and its preparation method. The composition is made from the following raw materials in parts by weight: 200-300 parts hawthorn, 200-300 parts kudzu root, and 200-300 parts rose petals. It can be prepared into oral liquid, tablets, capsules, and granules.

[0004] Hawthorn is the dried, ripe fruit of *Crataegus pinnatifida* Bge. var. *Major N.E.Br.* or *C. pinnatifida* Bge., belonging to the Rosaceae family. It has a sour and sweet taste and is slightly warm in nature. It enters the spleen, stomach, and liver meridians. Hawthorn is rich in various organic acids, such as hawthorn acid, citric acid, and malic acid. These components can promote gastric acid secretion and aid digestion, especially in the breakdown of fatty foods. It has the effects of promoting digestion, strengthening the stomach, regulating qi and blood circulation, and resolving turbidity and regulating lipids. It is used to treat indigestion, abdominal distension, diarrhea and abdominal pain, amenorrhea due to blood stasis, postpartum blood stasis, stabbing pain in the heart and abdomen, chest pain, hernia pain, and hyperlipidemia.

[0005] According to the Pharmacopoeia, kudzu root is sweet and pungent in taste, cool in nature, and enters the spleen, stomach, and lung meridians. It relieves muscle tension and reduces fever, promotes body fluid production and quenches thirst, promotes rash eruption, raises yang and stops diarrhea, unblocks meridians and collaterals, and detoxifies alcohol. As a traditional Chinese medicine and food ingredient, kudzu root is highly regarded for its rich nutritional value. It contains various active ingredients, such as isoflavones, dietary fiber, and minerals, which can help improve the body's digestive function. Traditional Chinese medicine believes that kudzu root has the effect of strengthening the spleen and improving appetite, and is especially suitable for people with weak spleen and stomach and poor appetite. Modern research also shows that certain components in kudzu root can promote intestinal peristalsis and help relieve constipation.

[0006] Roses are rich in vitamin C, amino acids, soluble sugars, alkaloids, and minerals such as calcium and iron. They have the effects of promoting blood circulation, warming the stomach and spleen, and soothing the liver and relieving depression. The Compendium of Materia Medica records that roses are warm in nature, sweet and slightly bitter in taste, and mainly act on the liver and spleen meridians. Traditional Chinese medicine believes that stagnation of liver qi can affect the spleen and stomach's digestive function (i.e., "liver wood controls spleen earth"), and the liver-soothing and depression-relieving properties of roses can indirectly improve problems such as abdominal distension and loss of appetite caused by emotional stress.

[0007] During the preparation of this traditional Chinese medicine composition, the active ingredients in hawthorn, kudzu root, and rose, such as organic acids and flavonoids, are easily affected by temperature and pH during storage, leading to degradation or oxidation and poor stability. Furthermore, for liquid dosage forms, hawthorn is sour and kudzu root is bitter, resulting in poor patient acceptance. Although adding honey during oral liquid preparation can improve the taste to some extent, the enzymes in honey may accelerate the degradation and deterioration of the active ingredients.

[0008] Therefore, it is necessary to improve the excipients and preparation processes of existing liquid formulations to enhance the stability of the formulation while ensuring its taste, thereby improving its bioavailability. Summary of the Invention

[0009] To address the problems existing in the prior art, this invention provides a traditional Chinese medicine oral liquid for invigorating the spleen and treating anorexia, and its preparation method.

[0010] The technical solution of the present invention is as follows:

[0011] In a first aspect, the present invention provides a traditional Chinese medicine oral liquid for invigorating the spleen and treating anorexia. The traditional Chinese medicine oral liquid includes raw materials, sweeteners, isotonic agents and water. The raw materials include, by weight, 2-3 parts hawthorn, 2-3 parts kudzu root and 1-2 parts rose. The sweeteners are honey, xylitol and maltitol.

[0012] As some preferred embodiments of the present invention, the raw materials include, by weight, 2.5 parts hawthorn, 2.5 parts kudzu root and 1.5 parts rose.

[0013] As some preferred embodiments of the present invention, the mass ratio of honey, xylitol and maltitol is 1:0.01-0.1:0.2-0.8.

[0014] As some preferred embodiments of the present invention, the isotonic agent includes one or more of sodium chloride, sodium bicarbonate, sodium citrate, potassium chloride, and glucose; preferably sodium chloride.

[0015] As some preferred embodiments of the present invention, the amount of raw medicinal material in the oral liquid is 0.5-1.2 g / mL, calculated as raw medicinal material.

[0016] Furthermore, the sweetener accounts for 1-5% (w / v) of the traditional Chinese medicine oral liquid; and / or the isotonic agent accounts for 0.1-2% (w / v) of the traditional Chinese medicine oral liquid.

[0017] Secondly, the present invention provides a method for preparing the above-mentioned oral liquid of traditional Chinese medicine, comprising the following steps: (1) After crushing the rose petals, steam distill them to separate the initial distillate, leaving 1 residue. (2) After crushing the kudzu root, mix it with the dregs 1, add it to the alcohol solution, and perform alcohol extraction. After separation, the alcohol extract and dregs 2 are obtained. (3) After crushing the hawthorn and mixing it with the dregs 2, add water and decoct. After separation, obtain the aqueous extract. (4) Combine the alcohol extract and water extract, concentrate until there is no alcohol taste, mix thoroughly with sweetener and isotonic agent, add the initial distillate and mix evenly, add the remaining water to obtain the final product.

[0018] As some specific embodiments of the present invention, in step (2), the alcohol solution is a 55-75% methanol solution or ethanol solution.

[0019] As some specific embodiments of the present invention, in step (2), the alcohol extraction is performed 1-3 times, and each extraction is performed by adding an alcohol solution with a total mass of 8-10 times that of rose petals and medicinal residue 1, and the extraction time is 1-2 hours.

[0020] As some specific embodiments of the present invention, in step (3), the number of decoctions is 1-3 times, and each time 5-8 times the total mass of hawthorn and dregs 2 is added, and the decoction time is 1-2 hours.

[0021] Compared with the prior art, the present invention has the following beneficial effects: This invention introduces xylitol and maltitol as sweeteners, reducing the amount of honey used. This avoids the cloying sweetness of honey and also reduces the impact of enzymes in honey on the stability of the active ingredients in traditional Chinese medicine. Furthermore, the addition of an isotonic agent ensures that the oral liquid is isotonic with the taste bud fluid, preventing the liquid from rapidly diffusing to the taste buds and reducing the stimulation of the taste buds by the sourness of hawthorn and the bitterness of kudzu root. The combination of sweeteners and isotonic agents improves the taste of the oral liquid from different angles, resulting in higher patient acceptance.

[0022] The method for preparing oral liquid traditional Chinese medicine of the present invention is simple and can be mass-produced. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Example 1 The prescription for the traditional Chinese medicine oral liquid provided in this embodiment is shown in Table 1, and the preparation method is as follows: Prescriptions 1-6: (1) Take rose petals, crush them, soak them in water for 2 hours, filter out the water, place them on the sieve plate of a steam distillation apparatus, and distill them at 98-100℃ and a steam flow rate of 1m / s for 3-4 hours (until the distillate is obtained) to get the initial distillate and the remaining residue 1; (2) Take kudzu root, crush it and mix it with the dregs 1. Add it to 70% (v / v) ethanol solution with a total mass of 8 times that of rose petals and dregs 1 and reflux extract twice, 1.5h each time. Combine the filtrates to obtain ethanol extract and the remaining dregs 2. (3) Take hawthorn, crush it and mix it with dregs 2. Add water with a total mass of 6 times that of hawthorn and dregs 2, decoct twice, 1.5h each time, combine the filtrates and obtain water extract; (4) Combine the alcohol extract and water extract, concentrate until there is no alcohol taste, mix thoroughly with sweetener and isotonic agent, add the initial distillate and mix evenly, add the remaining water to obtain Chinese medicine oral liquid 1-6.

[0025] Prescriptions 7-8: (1) Take rose petals, crush them, soak them in water for 2 hours, filter out the water, place them on the sieve plate of a steam distillation apparatus, and distill them at 98-100℃ and a steam flow rate of 1m / s for 3-4 hours (until the distillate is obtained) to get the initial distillate and the remaining residue 1; (2) Take kudzu root, crush it and mix it with the dregs 1. Add it to 55% (v / v) ethanol solution with a total mass of 10 times that of rose petals and dregs 1 and reflux extract twice, each time for 1.5h. Combine the filtrates to obtain ethanol extract and the remaining dregs 2. (3) Take hawthorn, crush it and mix it with dregs 2. Add water with a total mass of 6 times that of hawthorn and dregs 2, decoct twice, 1.5h each time, combine the filtrates and obtain water extract; (4) Combine the alcohol extract and water extract, concentrate until there is no alcohol taste, mix thoroughly with sweetener and isotonic agent, add the initial distillate and mix evenly, add the remaining water to obtain Chinese medicine oral liquid 7 and 8.

[0026] Table 1. Composition and dosage of each prescription in Example 1

[0027] Comparative Example 1 The composition of the active pharmaceutical ingredient is the same as that of Formula 1, and the preparation method is as follows: (1) Take rose petals, crush them, soak them in water for 2 hours, filter out the water, place them on the sieve plate of a steam distillation apparatus, and distill them at 98-100℃ and a steam flow rate of 1m / s for 3-4 hours (until the distillate is obtained) to get the initial distillate and the remaining residue 1; (2) Take kudzu root and hawthorn, crush them and mix them with the dregs 1. Add kudzu root, hawthorn and dregs 1 and decoct twice with water. Add 10 times the amount of water for the first time and decoct for 2 hours. Add 8 times the amount of water for the second time and decoct for 1 hour. Combine the decoction and the residue pressing liquid, filter, concentrate the filtrate to a relative density of 1.15, let it stand for more than 24 hours, and take the supernatant. (3) Add 80g of honey to the clear liquid, mix it evenly with the initial distillate, add water to make up to 1000mL, and obtain the Chinese medicine oral liquid 9.

[0028] Comparative Example 2 The raw materials and excipients are the same as those in Formula 1, and the preparation method is as follows: (1) Take rose petals, crush them, soak them in water for 2 hours, filter out the water, place them on the sieve plate of a steam distillation apparatus, and distill them at 98-100℃ and a steam flow rate of 1m / s for 3-4 hours (until the distillate is obtained) to get the initial distillate and the remaining residue 1; (2) Take kudzu root and hawthorn, crush them and mix them with the dregs 1. Add kudzu root, hawthorn and dregs 1 and decoct twice with water. Add 10 times the amount of water for the first time and decoct for 2 hours. Add 8 times the amount of water for the second time and decoct for 1 hour. Combine the decoction and the residue pressing liquid, filter, concentrate the filtrate to a relative density of 1.15, let it stand for more than 24 hours, and take the supernatant. (4) Mix the supernatant with the sweetener and isotonic agent thoroughly, then add the initial distillate and mix evenly. Add the remaining water to obtain 10 Chinese herbal oral liquid.

[0029] Comparative Example 3 The composition of the active pharmaceutical ingredient is the same as that of Formula 1, and the preparation method is as follows: (1) Take rose petals, crush them, soak them in water for 2 hours, filter out the water, place them on the sieve plate of a steam distillation apparatus, and distill them at 98-100℃ and a steam flow rate of 1m / s for 3-4 hours (until the distillate is obtained) to get the initial distillate and the remaining residue 1; (2) Take kudzu root, crush it and mix it with the dregs 1. Add it to 70% (v / v) ethanol solution with a total mass of 8 times that of rose petals and dregs 1 and reflux extract twice, 1.5h each time. Combine the filtrates to obtain ethanol extract and the remaining dregs 2. (3) Take hawthorn, crush it and mix it with dregs 2. Add water with a total mass of 6 times that of hawthorn and dregs 2, decoct twice, 1.5h each time, combine the filtrates and obtain water extract; (4) Combine the alcohol extract and water extract, concentrate until there is no alcohol taste, add 60g of honey and mix thoroughly, then add the initial distillate and mix evenly, add the remaining water to obtain 11 Chinese medicine oral liquid.

[0030] Test Example 1: Active Ingredient Content Using hawthorn total flavonoids and puerarin as examples, the content and stability of the active ingredients in the traditional Chinese medicine oral liquids prepared in the comparative proportions of the above examples were tested. The above traditional Chinese medicine oral liquids were subjected to accelerated incubation at 40℃ for 6 months, and the contents of hawthorn total flavonoids and puerarin in the oral liquids at the initial stage and the 6th month were tested respectively. The results are shown in Table 2.

[0031] The testing methods for active ingredients are as follows: (1) The total flavonoids in hawthorn (including hyperoside, vitexin and its glycosides, quercetin and its glycosides including rutin, etc.) were tested in accordance with “Determination of total flavonoids in health food, Technical Specifications for Inspection and Evaluation of Health Food 2003 Edition, Ministry of Health of the People’s Republic of China, p308”. (2) Puerarin was tested in accordance with "GB / T22251-2008 Determination of Puerarin in Health Food".

[0032] Table 2 Results of active ingredient content in traditional Chinese medicine oral liquids

[0033] As shown in the table above, the raw material compositions and preparation methods of oral Chinese medicine solutions 1-6 are the same, resulting in comparable contents of total hawthorn flavonoids and puerarin in the oral Chinese medicine solutions. The raw material compositions of oral Chinese medicine solutions 7, 8, and 11 are slightly different, leading to variations in the total hawthorn flavonoids and puerarin contents. However, the total hawthorn flavonoid content remains above 8 mg / mL, and the puerarin content remains above 5 mg / mL. In contrast, oral Chinese medicine solutions 9 and 10 have the same raw material composition as oral Chinese medicine solution 1, but only water extraction of kudzu root and hawthorn is used, resulting in a significant decrease in the contents of total hawthorn flavonoids and puerarin. This demonstrates that the present invention, through improvements in the raw material extraction process, effectively increases the content of effective active ingredients in oral Chinese medicine solutions, providing a basis for reducing drug dosage while increasing efficacy.

[0034] Furthermore, stability studies revealed that the composition of the sweetener had a certain impact on the stability of total hawthorn flavonoids and puerarin. Among them, the contents of total hawthorn flavonoids and puerarin in the Chinese herbal oral liquids 1, 5-8, and 10 remained almost unchanged compared with the initial values ​​under accelerated conditions, indicating higher stability.

[0035] Test Example 2: Effects of the Traditional Chinese Medicine Oral Liquid of the Present Invention on Gastrointestinal Function in Experimental Animals I. Effects on small intestinal absorption function in spleen-deficient rats: 130 SD rats, weighing 100±15g, half male and half female, were randomly and evenly divided into 13 groups: blank group, model group, and drug treatment groups 1-11, with 10 rats in each group. Except for the control group, all other groups were administered 2 mL / 100g of 100% rhubarb decoction by gavage every morning (the 100% rhubarb decoction was prepared as follows: take an appropriate amount of rhubarb slices, add 6 times the amount of water for the first time, soak for 30 min, and extract at 80 ℃ for 60 min; add 4 times the amount of water for the second time, and extract at 80 ℃ for 45 min; combine the two extracts, concentrate, and obtain a rhubarb decoction with a mass concentration of 2 g / mL). The control group was administered an equal amount of physiological saline. Each treatment group was administered the corresponding oral Chinese medicine liquid by gavage every afternoon at a dosage of 1 mL / 100g body weight / day. The control group and the model group were administered an equal amount of physiological saline by gavage. The administration was continued for 15 days. One hour after the last gavage, 1 mL / 100g of 3% D-xylose solution was administered by gavage. One hour later, blood was collected from the orbital cavity of the rats, and 0.05 ml of rat serum was collected by centrifugation and added to the test tube. Take two more test tubes. Add 0.05 mL of D-xylose standard solution to one tube and 0.05 mL of distilled water to the other. Add 5 mL of colorimetric reagent (prepared by mixing 0.5 g of phloroglucinol with 100 mL of glacial acetic acid and 10 mL of hydrochloric acid) to each tube and mix well. Heat in a 100℃ water bath for 4 min, then remove and cool in a cold water bath. Measure the absorbance of each tube using a spectrophotometer at a wavelength of 554 nm with a 1 cm path length. Zero the spectrophotometer using a distilled water tube and read the absorbance. Calculate the serum D-xylose content using the following formula:

[0036] In the formula, △ A 1 represents the OD value of the test tube minus the OD value of the distilled water test tube; △ A 2 represents the OD value of the D-xylose standard solution test tube versus the OD value of the distilled water test tube; c The standard concentration is 1.33 mmol / L. f The dilution factor of the sample before it is added to the monitoring system.

[0037] The percentage increase in serum D-xylose content in each group of rats compared to the control group was calculated, and the results are shown in Table 3.

[0038] Table 3. Effects of oral Chinese medicine liquid on small intestinal absorption function in rats with spleen deficiency (X±s, n=10)

[0039] Note: Compared with the blank group, ## P < 0.01; compared with the model group, && P < 0.01, &&& P < 0.001; compared with group 1, ^^ P < 0.01, ^^^P < 0.001; In the improvement rate results, "-" indicates that the serum D-xylose content of rats in the control group is reduced.

[0040] As shown in the table above, compared with the blank group, the serum D-xylose content of rats in the model group was significantly reduced (P<0.01), indicating that the model of spleen deficiency rats was successfully established. The serum D-xylose content of rats in treatment groups 1 and 5-8 was significantly increased (P<0.001), with an increase rate of about 30% compared with the blank group, which can significantly improve the absorption of D-xylose in rats with spleen deficiency. Treatment groups 2, 3 and 9-11 also had a certain effect on promoting the absorption of D-xylose in rats with spleen deficiency, but were worse than treatment group 1, and the differences were significant compared with treatment group 1 (P<0.01 or P<0.001). Among them, the difference in effect between treatment groups 2-4, treatment group 11 and treatment group 1 indicates that the composition of sweetener has a significant impact on the absorption of traditional Chinese medicine oral liquid in the small intestine of spleen-deficient rats; at the same time, combined with the data in Table 1, the difference in effect between treatment groups 9 and 10 and treatment group 1 indicates that the improvement of the raw material extraction process increased the content of effective components total flavonoids of hawthorn and puerarin, thereby improving the absorption function of the small intestine of spleen-deficient rats.

[0041] II. Effects on small intestinal propulsion One hundred and thirty C57BL / 6J mice, weighing 20±2g, with half males and half females, were randomly and evenly divided into 13 groups: blank group, model group, example groups 1-8, and comparative examples 1-3, with 10 mice in each group. Except for the blank group, the other groups were administered 100% rhubarb decoction by gavage once a day for one week (0.3mL / 10g body weight). The preparation method of 100% rhubarb decoction was as follows: Take an appropriate amount of rhubarb slices, add 6 times the amount of water for the first time, soak for 30 min, and extract at 80 ℃ for 60 min; add 4 times the amount of water for the second time, and extract at 80 ℃ for 45 min; combine the two extracts, concentrate, and obtain a mass concentration of 2. A spleen deficiency model was created by administering a 2% (g / mL) rhubarb decoction. The control group was given an equal volume of physiological saline. After fasting for 24 hours, the model group and the control group were given a suspension containing 2% ink prepared with sterile distilled water. The treatment groups 1-11 were given a suspension containing 2% ink prepared with the corresponding traditional Chinese medicine oral liquid and sterile distilled water (the dosage of the traditional Chinese medicine composition was 1 mL / 100g body weight). The volume of the suspension containing 2% ink in each group was 1 mL / 100g body weight. 30 minutes after administration, the mice were euthanized by cervical dislocation. The stomach and intestines were immediately removed by abdominal dissection and laid flat on a glass plate. The distance the ink tip moved in the intestine and the total length of the small intestine (from the pylorus to the ileum) were measured. The ink propulsion rate of the small intestine was calculated as: ink propulsion rate (%) = distance between the ink tip and the pylorus / total length of the small intestine × 100%. The results are shown in Table 4.

[0042] Table 4. Results of the effect of oral liquid traditional Chinese medicine on small intestinal propulsion (X±s, n=10)

[0043] Note: Compared with the blank group, ## P < 0.01; compared with the model group, && P < 0.01, &&& P < 0.001; compared with group 1, ^ P < 0.05 ^^ P < 0.01.

[0044] As shown in the table above, compared with the blank group, the intestinal ink propulsion rate of mice in the model group was significantly reduced (P<0.01), indicating that the model of spleen deficiency mice was successfully established. Compared with the model group, the intestinal ink propulsion rate of mice in each treatment group was significantly increased. Among them, compared with treatment group 1, the intestinal ink propulsion rate of mice in treatment groups 2-4 and treatment groups 9-11 was slightly lower, and the difference was significant. It can be seen that the present invention has achieved the improvement of small intestinal propulsion function in mice with spleen deficiency by selecting the type of sweetener excipient for traditional Chinese medicine oral liquid and improving the preparation process.

[0045] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A traditional Chinese medicine oral liquid for invigorating the spleen and treating anorexia, characterized in that, The oral liquid of traditional Chinese medicine includes raw materials, sweeteners, isotonic agents, and water; The raw materials, by weight, include: 2-3 parts hawthorn, 2-3 parts kudzu root, and 1-2 parts rose petals; The sweeteners are honey, xylitol, and maltitol.

2. The traditional Chinese medicine oral liquid according to claim 1, characterized in that, The raw materials, by weight, include: 2.5 parts hawthorn, 2.5 parts kudzu root, and 1.5 parts rose.

3. The traditional Chinese medicine oral liquid according to claim 1, characterized in that, The mass ratio of honey, xylitol, and maltitol is 1:0.01-0.1:0.2-0.

8.

4. The traditional Chinese medicine oral liquid according to claim 1, characterized in that, The isotonic agent includes one or more of sodium chloride, sodium bicarbonate, sodium citrate, potassium chloride, and glucose; preferably sodium chloride.

5. The traditional Chinese medicine oral liquid according to claim 1, characterized in that, The amount of raw materials in the oral liquid of traditional Chinese medicine is 0.5-1.2 g / mL, calculated based on the amount of raw medicinal materials.

6. The traditional Chinese medicine oral liquid according to claim 1, characterized in that, The sweetener accounts for 1-5% (w / v) of the oral liquid of traditional Chinese medicine; and / or the isotonic agent accounts for 0.1-2% (w / v) of the oral liquid of traditional Chinese medicine.

7. The method for preparing the traditional Chinese medicine oral liquid according to any one of claims 1-6, characterized in that, Includes the following steps: (1) After crushing the rose petals, steam distill them to separate the initial distillate, leaving 1 residue. (2) After crushing the kudzu root, mix it with the dregs 1, add it to the alcohol solution, and perform alcohol extraction. After separation, the alcohol extract and dregs 2 are obtained. (3) After crushing the hawthorn and mixing it with the dregs 2, add water and decoct. After separation, obtain the aqueous extract. (4) Combine the alcohol extract and water extract, concentrate until there is no alcohol taste, mix thoroughly with sweetener and isotonic agent, add the initial distillate and mix evenly, add the remaining water to obtain the final product.

8. The preparation method according to claim 7, characterized in that, In step (2), the alcohol solution is a 55-75% methanol solution or ethanol solution.

9. The preparation method according to claim 7, characterized in that, In step (2), the alcohol extraction is performed 1-3 times, with each extraction involving 8-10 times the total mass of rose petals and medicinal residue in alcohol solution, and the extraction time is 1-2 hours.

10. The preparation method according to claim 7, characterized in that, In step (3), the decoction is performed 1-3 times, with 5-8 times the total mass of hawthorn and dregs added each time, and the decoction time is 1-2 hours.

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