A method for synthesizing deoxycholic acid (DCA)

By using phytosterols as starting material and employing steps such as oxidation and Witting reaction to synthesize deoxycholic acid, the problems of low yield and harsh reaction conditions in existing technologies have been solved, achieving high-purity and low-cost industrial production and avoiding the risk of animal pathogens.

CN117447545BActive Publication Date: 2026-07-24SHANGHAI GAOZHUN PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI GAOZHUN PHARMA CO LTD
Filing Date
2023-10-27
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing methods for synthesizing deoxycholic acid have long routes, low yields, and harsh reaction conditions in intermediate processes, making them unsuitable for industrial production. They may also contain animal pathogens and harmful substances.

Method used

Deoxycholic acid was synthesized from phytosterols through oxidation, Witting reaction, palladium-catalyzed hydrogenation on carbon, reduction, acetylation, elimination reaction and oxidation. The intermediate was a solid that was easy to purify and the post-processing was simple.

Benefits of technology

It improves synthesis yield and purity, avoids the risk of animal pathogens, is suitable for industrial production, and reduces costs.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a synthesis method of deoxycholic acid (DCA). The method takes phytosterol as a starting material, and synthesizes deoxycholic acid (DCA) through a series of steps such as primary alcohol oxidation reaction, witting reaction, hydrogenation reaction, selective reduction reaction, hydroxyl protection reaction, elimination reaction, allyl oxidation reaction and hydrolysis reaction. The synthesis method has high reaction yield and high product purity, the intermediates in each step are all solid, easy to purify, the post-treatment method is simple, the cost is low, suitable for quality control, convenient for industrialized production, and has a good application prospect. Moreover, the deoxycholic acid (DCA) synthesized by the method also avoids the risk of containing animal pathogens and other harmful factors.
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