Intracavitary hot perfusion circulation line

Abstract

The present application relates to a kind of intracavity hot perfusion circulation pipeline, including heating tank, liquid inlet pipeline, liquid outlet pipeline, circulating pump, pre-charging pipeline, liquid return pipeline, intracavity pipeline and out of cavity pipeline, and the liquid storage cavity is formed in heating tank, liquid inlet pipeline is connected with the liquid storage cavity, liquid medicine is entered into the liquid storage cavity of heating tank via liquid inlet pipeline, when the liquid medicine amount in heating tank reaches the set value, liquid inlet pipeline is closed, the liquid medicine in heating tank is preheated by electromagnetic induction heating device until reach preheating temperature, liquid medicine is extracted from the liquid storage cavity under the action of circulating pump, after liquid outlet pipeline, pre-charging pipeline and liquid return pipeline, it flows back into heating tank, so air in pipeline system can be pre-removed to avoid causing inflammation.Then liquid medicine is extracted from the liquid storage cavity again under the action of circulating pump, after liquid outlet pipeline, intracavity pipeline, it enters bladder, then flows out from bladder, after out of cavity pipeline, liquid return pipeline, it flows back into heating tank.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an intracavitary hot perfusion circulation tubing. Background Technology

[0002] After tumor resection or debulking surgery, heated saline and anticancer drugs need to be directly infused into the patient's cavities (such as the pleural cavity, abdominal cavity, or bladder) to allow the anticancer drugs to directly and fully contact the tumor tissue or cells, thus acting as an adjunct to chemotherapy. Basic research in tumor hyperthermia has confirmed that tumor tissue is heat-sensitive. Using an extracorporeal heating device for hyperthermic perfusion, the treatment solution is heated and introduced into the patient's body cavity using a circulation pump, maintaining an effective therapeutic temperature for a certain period to fully utilize the thermal killing mechanism. This effectively kills metastatic cancer cells widely implanted on the serosal membrane, eliminates lesions causing malignant effusions, and achieves the goal of effectively treating cancerous effusions. Intraoperative and postoperative use of heated treatment solutions for thermal cleansing can prevent the diffuse spread of cancer cells within the cavities.

[0003] However, when using traditional circulatory tubing for hyperthermic perfusion therapy, it is impossible to expel air from the tubing system. If too much air enters the body cavity, it may cause symptoms such as inflammation. Summary of the Invention

[0004] Therefore, it is necessary to provide an intracavitary hot perfusion circulation pipeline that can pre-emptively purge air from the pipeline system to avoid causing inflammation, in order to address the aforementioned technical problems.

[0005] An intracavitary hot infusion circulation tubing includes:

[0006] The heating tank is hollow to form a liquid storage cavity, which is used to store the medicine liquid.

[0007] The liquid inlet pipe has one end connected to the liquid storage chamber and the other end connected to the medicine bag;

[0008] One end of the liquid outlet pipe is connected to the liquid storage chamber;

[0009] A circulation pump, connected in series with the liquid outlet pipeline, is used to extract the liquid medicine from the storage chamber;

[0010] The pre-filling pipeline is connected at one end to the other end of the liquid outlet pipeline;

[0011] The return line is connected at one end to the other end of the pre-filling line and at the other end to the liquid storage chamber.

[0012] An inlet tube, one end of which is connected to the other end of the outlet tube, and the other end is used to connect to the body cavity; and

[0013] The outlet conduit has one end connected to the body cavity and the other end connected to one end of the return fluid conduit. The pre-filling conduit is connected in parallel with the inlet conduit and the outlet conduit.

[0014] The above-mentioned intracavitary hot infusion circulation pipeline has at least the following advantages:

[0015] During use, the liquid medicine enters the storage chamber of the heating tank through the inlet pipe. When the amount of liquid medicine in the heating tank reaches the set value, the inlet pipe is closed. The liquid medicine in the heating tank is preheated by an electromagnetic induction heating device until the preheating temperature is reached. The liquid medicine is then drawn out of the storage chamber by the circulation pump and flows back into the heating tank through the outlet pipe, pre-filling pipe, and return pipe. This allows air in the piping system to be purged beforehand to avoid causing inflammation. Then, the liquid medicine is drawn out of the storage chamber again by the circulation pump and enters the bladder through the outlet pipe and inlet pipe. It then flows out of the bladder and flows back into the heating tank through the outlet pipe and return pipe. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the intracavitary hot perfusion circulation pipeline in one embodiment;

[0017] Figure 2 for Figure 1 A partial schematic diagram;

[0018] Figure 3 for Figure 1 Another partial schematic diagram;

[0019] Figure 4 This is a schematic diagram of the structure of the heating tank in one embodiment;

[0020] Figure 5 for Figure 4 Partial cross-sectional view of the heating tank shown;

[0021] Figure 6 for Figure 4 An exploded view of the heating tank shown.

[0022] Figure 7 This is a schematic diagram of the structure of a two-way valve in one embodiment;

[0023] Figure 8 for Figure 7 An exploded view of the two-way valve shown.

[0024] Figure 9 for Figure 7 A schematic diagram of the two-way valve from another perspective;

[0025] Figure 10 For along Figure 9 Sectional view of line AA in the middle;

[0026] Figure 11 This is an exploded view of the dosing connector in one embodiment;

[0027] Figure 12 for Figure 11 The diagram shows a cross-sectional view of the assembled dosing connector.

[0028] Figure 13 This is an exploded view of an inlet flow indicator in one embodiment;

[0029] Figure 14 for Figure 13 The cross-sectional view shown is of the inlet flow indicator after assembly.

[0030] Figure 15 This is an exploded view of the cavity temperature sensor in one embodiment;

[0031] Figure 16 for Figure 15 The cross-sectional view of the in-cavity thermometer after assembly is shown.

[0032] Figure 17 This is an exploded view of a filter in one embodiment;

[0033] Figure 18 for Figure 17 The image shows a cross-sectional view of the assembled filter. Detailed Implementation

[0034] To make the above-mentioned objects, features, and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of the present invention. However, the present invention can be practiced in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0035] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly attached to the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0036] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the specification is for the purpose of describing particular embodiments only and is not intended to limit the invention. The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described; however, any combination of these technical features that does not contradict each other should be considered within the scope of this specification.

[0037] Please see Figure 1 In one embodiment, the intracavitary hyperthermic perfusion circulation tubing 10 can be applied in a bladder hyperthermic perfusion device to form a circulation tubing system connected to a catheter placed in the bladder. Before treatment, air in the tubing system can be pre-emptively removed to prevent inflammation. Furthermore, when used in conjunction with an electromagnetic induction heating device, it can maintain the chemotherapy drugs filling the bladder at a set hyperthermic temperature for an extended period, thereby achieving the killing effect of chemotherapy drugs and hyperthermia on superficial bladder tumors. Of course, in other embodiments, it can also be applied to the pleural cavity, abdominal cavity, or rectum for treatment.

[0038] Please refer to the following: Figure 2 and Figure 3 The intracavitary hot perfusion circulation pipeline 10 includes a heating tank 100, an inlet pipeline 101, an outlet pipeline 102, a circulation pump 200, a pre-filling pipeline 103, a return pipeline 104, an inlet pipeline 105, and an outlet pipeline 106. The heating tank 100 is hollow to form a storage chamber 100a, which is used to store the liquid medicine. One end of the inlet pipeline 101 is connected to the storage chamber 100a, and the other end is used to connect to a liquid medicine bag (or liquid medicine bottle, liquid medicine container, etc.). One end of the outlet pipeline 102 is connected to the storage chamber 100a, and the other end is connected to one end of the pre-filling pipeline 103 and one end of the inlet pipeline 105. The pre-filling pipeline 103 and the inlet pipeline 105 are arranged in parallel. For example, a suction pipe 107 can be connected in series at one end of the outlet pipe 102. The suction pipe 107 extends into the storage chamber 100a and one end is close to the bottom of the heating tank 100 to ensure that the medicine in the heating tank 100 can be smoothly drawn into the outlet pipe 102.

[0039] A circulation pump 200 is connected in series in the liquid outlet pipeline 102 to extract the liquid from the storage chamber 100a. Specifically, the circulation pump 200 includes a pump pipe 210 and two pump pipe connectors 220, which are respectively connected to opposite ends of the pump pipe 210 to connect the pump pipe 210 in series in the liquid outlet pipeline 102. The pump pipe 210 is used to adjust the speed at which liquid is extracted from the heating tank 100.

[0040] One end of the pre-filling line 103 is connected to the other end of the outlet line 102, and the other end is connected to one end of the return line 104. The pre-filling line 103 is connected in parallel with the inlet line 105 and the outlet line 106. A pre-filling valve 1031 is also connected in series with the pre-filling line 103 to control the opening and closing of the pre-filling line 103. One end of the return line 104 is connected to the other end of the pre-filling line 103 and the other end of the outlet line 106, and the other end is connected to the storage chamber 100a. The return line 104 can return the medicine solution in the bladder discharged from the outlet line 106 to the heating tank 100. For example, a three-way valve can be used to connect the return line 104, the pre-filling line 103, and the outlet line 106.

[0041] One end of the inlet tube 105 is connected to the other end of the outlet tube 102, and the other end is used to connect to a body cavity (bladder in this embodiment). The inlet tube 105 can introduce the medication into the bladder. Specifically, an inlet valve 1051 can be connected in series with the inlet tube 105 to control the opening and closing of the inlet tube 105. An inlet cone 1052 can also be provided at the other end of the inlet tube 105 to facilitate its use with a catheter. Optionally, a protective cap 1053 can be fitted onto the inlet cone 1052 to protect the inlet cone 1052 when not in use and prevent external dust or debris from entering the inlet tube 105.

[0042] One end of the outlet tubing 106 is connected to a body cavity (bladder in this embodiment), and the other end is connected to a return tubing 104. The pre-filling tubing 103 is connected in parallel with the inlet tubing 105 and the outlet tubing 106. The outlet tubing 106 can draw out the medication from the bladder and return it to the heating tank 100 via the return tubing 104. Specifically, an outlet valve 1061 can be connected in series with the outlet tubing 106 to control the opening and closing of the outlet tubing 106. An outlet cone 1062 can also be provided at one end of the outlet tubing 106 for easy connection with a catheter. Optionally, a protective cap 1063 can be fitted onto the outlet cone 1062 to protect the outlet cone 1062 when not in use and prevent external dust or impurities from entering the outlet tubing 106.

[0043] Please see Figures 4 to 6The heating container 100 is a non-deformable container. The heating container 100 includes a container body 110 and a lid 120. The container body 110 is hollow and open at one end. The lid 120 covers the open end of the container body 110. The lid 120 and the container body 110 together form a liquid storage chamber 100a, which is used to store liquid. In use, the container body 110 is placed on an electromagnetic induction heating device, which heats the container body to indirectly heat the liquid in the liquid storage chamber 100a. This non-direct contact heating method avoids contamination of the liquid and thus meets aseptic requirements.

[0044] Specifically, in this embodiment, the tank 110 includes a shell 111 and a base 112. The base 112 is disposed at the bottom of the tank 110. The shell 111 is made of plastic, and the base 112 is made of metal. The base 112 and the shell 111 are integrally formed by injection molding. Therefore, the overall cost of the heating tank 100 is low, and the manufacturing process is simple, making it convenient for use as a disposable product. When the electromagnetic induction coil is energized, only the bottom of the heating tank 100 is heated, and the natural convection of the liquid in the heating tank 100 is used to achieve uniform heating of the liquid in the heating tank 100. For example, the base 112 can be made of medical-grade 304 stainless steel.

[0045] Of course, in other embodiments, the tank 110 has a bottom that is away from the opening end, and only the bottom of the tank 110 is made of metal, while the rest is made of plastic. Alternatively, the tank 110 can be made entirely of metal, so that when the electromagnetic induction coil is energized, it is used to heat the heating tank 100, thereby indirectly heating the liquid inside the heating tank 100.

[0046] Specifically, in this embodiment, the heating tank 100 further includes an air filter 130 and a sealing cap 140. A mating joint 150 is formed on the cover 120. The air filter 130 is connected to the liquid storage chamber 100a through the mating joint 150, and the sealing cap 140 can seal the air filter 130. The air filter 130 is mainly used to prevent bacteria or particles in the air from directly entering the liquid storage chamber 100a and causing contamination of the liquid when the air pressure inside the tank 110 is at atmospheric pressure. Specifically, the air filter 130 includes a multi-layer air filter element for filtering outside air to prevent bacteria carried in the air from entering the liquid storage chamber 100a. For example, the air filter 130 includes a shell made of ABS or AS material and a filter membrane made of PP or PTFE material, with a filtration rate of more than 90% for 0.5-micron particles in the air.

[0047] Specifically, the air filter 130 and the mating connector 150 are connected by a threaded connection. The air filter 130 has a through hole, and the air filter element is located within the through hole. A sealing cap 140 is rotatably mounted on the air filter 130 and can seal the through hole. The sealing cap 140 is mainly used to regulate the pressure in the storage chamber 100a. Since the tank 110 is made of a non-deformable material, changes in the volume of the medicine in the tank 110 will cause changes in the pressure inside the tank 110. For example, when medicine is injected into the heating tank 100, the pressure inside the tank 110 increases simultaneously with the increase in the amount of medicine, which may eventually lead to the pressure inside the tank 110 being equal to the pressure of the injected medicine, making it impossible to inject more medicine. Alternatively, when the tank 110 is full, after the medicine in the storage chamber 100a is extracted, a negative pressure will be generated inside the storage chamber 100a. Adjusting this negative pressure can help to draw out the medicine from the bladder.

[0048] Specifically, in this embodiment, the heating tank 100 further includes a first temperature measuring component 160. The first temperature measuring component 160 is used to accurately measure the temperature of the liquid in the liquid storage chamber 100a to monitor the liquid temperature in real time. The first temperature measuring component 160 includes a first temperature sensor and a first hollow tube. The first temperature sensor has a first probe end, which extends into the first hollow tube and is located at the end of the first hollow tube. One end of the first hollow tube extends into the liquid storage chamber 100a and is positioned near the bottom of the tank body 110. This ensures that the first temperature measuring component 160 is always in contact with the liquid, guaranteeing that the measured temperature is the true temperature of the liquid, rather than the temperature of the air above the liquid surface. However, there is a certain distance between one end of the first temperature measuring component 160 and the bottom to avoid the influence of the electromagnetic induction heating device, which could cause it to overheat or be interfered with, resulting in inaccurate measurements.

[0049] The heating tank 100 also includes a stirring impeller 170, which is located within the liquid storage chamber 100a and below the return liquid pipeline 104. The stirring impeller 170 rotates under the action of the liquid returning from the return liquid pipeline 104 to the liquid storage chamber 100a. Specifically, the stirring impeller 170 is mounted on the side of the cover 120 facing the tank body 110 via a support frame 180. The stirring impeller 170 includes stirring blades 171 and a rotating shaft 172. Both ends of the rotating shaft 172 are rotatably mounted on the support frame 180, and the stirring blades 171 are fixed to the rotating shaft 172. Of course, in other embodiments, the rotating shaft 172 may also be fixed to the support frame 180, and the stirring blades 171 may be rotatable relative to the rotating shaft 172.

[0050] When the storage chamber 100a is filled with liquid, the electromagnetic induction heating device indirectly heats the liquid through the heating tank 100. Since the base 112 or the bottom of the tank 110 is made of stainless steel, heat is transferred to the liquid from the bottom of the tank 110. The liquid's density decreases after heating, causing it to rise naturally, while the cooler liquid at the top sinks, creating a natural convection process. During this process, the stirring impeller 170 also rotates, thus providing a stirring effect.

[0051] Please refer to it again. Figure 1 and Figure 2 The intracavitary hot perfusion circulation line 10 also includes a pressure measuring component 300. The pressure measuring component 300 is connected in series with the outlet line 102 and is located behind the station of the circulation pump 200. The pressure measuring component 300 is used to measure the pressure in the outlet line 102 behind the station of the circulation pump 200. Therefore, the pressure in the outlet line 102 can be monitored to prevent excessive pressure from damaging the bladder or insufficient pressure from preventing the medication from entering the bladder.

[0052] Specifically, the pressure measuring assembly 300 includes a pressure measuring extension tube 310, a pressure measuring valve 320, and a pressure measuring protective cap 330. The pressure measuring extension tube 310 is connected in series with the outlet pipeline 102 and is located behind the station of the circulating pump 200. The pressure measuring valve 320 is used to control the opening and closing of the pressure measuring extension tube 310, and the pressure measuring protective cap 330 is sleeved on one end of the pressure measuring extension tube 310. The pressure of the medicine solution flowing out of the circulating pump 200 in the outlet pipeline 102 can be monitored in real time by connecting the pressure measuring extension tube 310 externally to the pressure sensor.

[0053] The inlet pipe 101 is equipped with a needle 108 at one end, which is connected to the medicine bag. The needle 108 is inserted into the medicine bag to smoothly introduce the medicine into the inlet pipe 101. Optionally, a protective cap 109 can be fitted onto the needle 108 to cover it, preventing accidental injury to the operator and also preventing external impurities and dust from entering the inlet pipe 101 through the needle.

[0054] Please refer to the following: Figure 2 , Figures 7 to 10 The intracavitary hot infusion circulation pipeline 10 also includes a two-way valve 400, which is connected in series in the liquid inlet pipeline 101 and used to control the opening and closing of the liquid inlet pipeline 101. The two-way valve 400 includes a valve body, which includes a valve core 410 and a valve body 420. The valve core 410 has a liquid passage hole 411, for example, the liquid passage hole 411 extends radially along the valve core 410. Of course, in other embodiments, the liquid passage hole 411 may not be limited to extending radially, for example, it may also be a curved through hole, etc.

[0055] The valve body 420 is open at at least one end and hollow inside to form a receiving cavity. The valve core 410 is generally cylindrical, and the receiving cavity is generally a circular hole to facilitate the rotation of the valve core 410 within the receiving cavity. A first liquid inlet channel 421 and a first liquid outlet channel 431 communicating with the receiving cavity are formed on the side wall of the valve body 420. One end of the valve core 410 extends into the receiving cavity, and the valve core 410 is rotatable relative to the valve body 420, so that the liquid passage 411 can be connected to or not connected to the first liquid inlet channel 421 and the first liquid outlet channel 431.

[0056] Specifically, in this embodiment, a positioning groove is recessed on the outer wall of the end of the valve core 410 that extends into the receiving cavity, and a positioning protrusion ring that cooperates with the positioning groove is protruded on the inner wall of the receiving cavity. Therefore, the positions of the valve core 410 and the valve body 420 can be positioned by the cooperation of the positioning groove and the positioning protrusion ring, preventing the valve core 410 from extending excessively into the valve body 420.

[0057] Specifically, in this embodiment, the other end of the valve core 410 extends out of the receiving cavity, and an operating handle 430 protrudes from the other end of the valve core 410. The operating handle 430 can be manually operated to rotate the valve core 410 relative to the valve body 420. Of course, in other embodiments, the valve core 410 can also be driven by a motor to rotate relative to the valve body 420 to achieve automatic on / off switching.

[0058] Please refer to the following: Figure 2 , Figure 11 and Figure 12 The intracavitary hyperthermic perfusion circulation line 10 also includes a drug delivery connector 500, which is connected in series with the inlet line 101. Chemotherapy drugs can be injected into the inlet line 101 through the drug delivery connector 500. The drug delivery connector 500 includes a drug delivery tube body 510, a handle 520, and a protective wing plate 530. An infusion channel 510a is formed inside the drug delivery tube body 510, which is connected to the inlet line 101. A drug delivery hole 511 is formed on the side wall of the drug delivery tube body 510, which is connected to the infusion channel 510a. A drug delivery soft plug 540 is provided on the drug delivery tube body 510 to seal the drug delivery hole 511, preventing air or other dust from entering the pipeline system. Specifically, the drug delivery soft plug 540 can be a silicone plug. Of course, in other embodiments, the soft stopper 540 can also be made of other soft materials, as long as it can seal the dosing hole 511 and allow the needle tip of the syringe to be inserted.

[0059] A handle 520 is disposed on the outer wall of the dosing tube 510, spaced apart from the dosing port 511. A protective wing plate 530 is disposed on the outer wall of the dosing tube 510, located between the dosing port 511 and the handle 520 to form a protective wall. Therefore, when one hand holds the handle 520 and the other hand holds the syringe, and the needle tip of the syringe is inserted into the dosing stopper 540, the protective wing plate 530 forms a protective wall between the hand and the needle tip, effectively preventing the needle tip from injuring the hand due to careless operation.

[0060] Please see Figure 3 , Figure 13 and Figure 14 The intracavitary hot-fill circulation pipeline 10 also includes an inlet flow indicator 600, which is connected in series in the outlet pipeline 102. For example, in this embodiment, the inlet flow indicator 600 is located behind the pressure measuring component 300. The inlet flow indicator 600 makes it easier to observe the flow of liquid in the pipeline system.

[0061] Specifically, the inlet flow indicator 600 includes a base 610, an impeller 620, a transparent cover 630, and a light-shielding top cover 640. The base 610 forms an impeller cavity 610a, which is connected to the outlet pipe 102. The impeller 620 is rotatably mounted on the base 610 via a rotating shaft 650 and is located within the impeller cavity 610a. The transparent cover 630 is mounted on the base 610 to seal the impeller cavity 610a. The light-shielding top cover 640 is closedly mounted on the base 610 and can cover the transparent cover 630.

[0062] The base 610 is made of a light-blocking material, and the transparent cover 630 can be made of a transparent material, such as transparent plastic or transparent glass. When the liquid enters the impeller chamber 610a, due to the continuity of the liquid, it will wash over the impeller 620. The impeller 620 rotates under the action of the flowing liquid. By observing whether the impeller 620 is rotating through the transparent cover 630, it can be determined whether the liquid is in a flowing state.

[0063] Impeller 620 is eccentrically positioned relative to impeller cavity 610a to accommodate lower flow rates. When a flow indicator is applied to a bladder circulation hyperthermic irrigation device, the flow rate in the tubing system during treatment is typically between 50 ml / min and 200 ml / min, and in most cases below 150 ml / min. Such a speed is relatively slow, thus requiring increased sensitivity of impeller 620 rotation.

[0064] Please refer to the following: Figure 3 , Figures 15 to 16The intracavitary hot perfusion circulation line 10 also includes an inlet thermometer 700, which is connected in series in the outlet line 102. The inlet thermometer 700 is used to measure the temperature of the liquid flowing in the outlet line 102 in real time to monitor the true temperature of the liquid entering the bladder. For example, in this embodiment, the inlet thermometer 700 is located behind the inlet flow indicator 600.

[0065] The inlet temperature sensor 700 includes a first liquid storage housing 710, a second temperature sensing component 720, a first inlet end cap 730, and a second inlet end cap 740. The first liquid storage housing 710 is hollow to form a first liquid storage chamber 710a, which is connected to the liquid outlet pipe 102. The first liquid storage housing 710 includes a first small-diameter end 711 and a first large-diameter end disposed opposite to each other, wherein the inner diameter of the first small-diameter end 711 is smaller than the inner diameter of the first large-diameter end 712.

[0066] The second temperature measuring component 720 includes a second hollow tube 721 and a second temperature sensor. The second temperature sensor has a second probe end 722, which extends into the second hollow tube 721 and is located at the end of the second hollow tube 721. A first inlet end cap 730 covers the first large-diameter end 712 of the first liquid storage housing 710, and a second inlet end cap 740 is disposed at the first small-diameter end 711 of the first liquid storage housing 710. The second hollow tube 721 extends into the first liquid storage chamber 710a through the first inlet end cap 730 and is adjacent to the first liquid inlet through hole 741 on the second inlet end cap 740.

[0067] If the second probe end 722 of the second temperature sensor is too close to or directly attached to the side wall of the first liquid storage shell 710, the measured temperature will be 1-2°C lower than the actual liquid temperature due to unavoidable heat dissipation from the first liquid storage shell 710. If the second probe end 722 of the second temperature sensor is located in the middle of the first liquid storage chamber 710a, the measured temperature will also be 1°C lower than the actual liquid temperature because there will be a stagnant water zone or the flow rate will be slower than the actual flow rate of the liquid in the pipeline. Therefore, in this embodiment, the second probe end 722 is positioned near the first liquid inlet hole, but not in direct contact with the first liquid storage shell 710.

[0068] Please see Figure 3 The intracavitary hot perfusion circulation line 10 also includes an outlet temperature sensor 700', which is connected in series in the return line 104 to measure the temperature of the liquid flowing out of the bladder through the outlet line 106 in real time. Specifically, the structure of the outlet temperature sensor 700' is roughly the same as that of the inlet temperature sensor 700.

[0069] The outlet temperature sensor 700' includes a second liquid storage shell, a third temperature sensing component, a first outlet end cap, and a second outlet end cap. The interior of the second liquid storage shell is hollow to form a second liquid storage chamber, which is connected to the return liquid pipeline 104. The second liquid storage shell includes a second small-diameter end and a second large-diameter end disposed opposite to each other, with the inner diameter of the second small-diameter end being smaller than the inner diameter of the second large-diameter end.

[0070] The third temperature sensing component includes a third hollow tube and a third temperature sensor. The third temperature sensor has a third probe end that extends into and is located at the end of the third hollow tube. A first outlet end cap covers the second large-diameter end of the second liquid storage shell, and a second outlet end cap is located at the second small-diameter end of the second liquid storage shell. The third hollow tube extends into the second liquid storage chamber through the first outlet end cap and is adjacent to the second liquid inlet hole on the second outlet end cap.

[0071] If the third probe of the third temperature sensor is too close to or directly attached to the side wall of the second liquid storage shell, the measured temperature will be 1-2°C lower than the actual liquid temperature due to unavoidable heat dissipation from the second liquid storage shell. If the third probe is located in the middle of the second liquid storage chamber, a stagnant zone or a flow rate slower than the actual liquid flow rate in the pipeline will also result in a measured temperature 1°C lower than the actual liquid temperature. Therefore, in this embodiment, the third probe is positioned near the second liquid inlet hole, but not in direct contact with the second liquid storage shell.

[0072] Please refer to the following: Figure 2 , Figure 17 and Figure 18 The intracavitary hyperthermic perfusion circulation line 10 also includes a filter 800, which is connected in series in the return line 104. For example, the filter 800 is located behind the outlet thermometer 700'. The filter 800 can filter the medication flowing from the bladder to prevent detached tissue from damaging other components.

[0073] Specifically, the filter 800 includes a housing 810, a filter element 820, an upper cover 830, and a lower cover 840. The housing 810 forms a filter element cavity 810a, which is connected to the return liquid pipeline 104. The filter element 820 is housed within the filter element cavity 810a and is used to filter the pharmaceutical solution. Specifically, the housing 810 can be a hollow cylinder. The filter element 820 includes a support 821 and a filter screen 822, with the filter screen 822 disposed on the support 821. The upper cover 830 is disposed at one end of the housing 810, and the lower cover 840 is disposed at the other end of the housing 810.

[0074] One end of the housing 810 has a sidewall that protrudes outward to form a positioning step 811. The bracket 821 includes a positioning cylinder 8211 and at least two reinforcing ribs 8212. The positioning cylinder 8211 abuts against the positioning step 811. One end of the reinforcing rib 8212 is disposed on the positioning cylinder 8211, and the reinforcing ribs 8212 are distributed radially at intervals. When the filter element 820 is assembled into the housing 810, one end of the filter element 820 extends into the filter element cavity 810a until the positioning cylinder 8211 abuts against the positioning step 811, thus completing the assembly. This facilitates assembly and disassembly.

[0075] Please see Figure 2 The intracavitary hot filling circulation pipeline 10 also includes an outlet flow indicator 600', which is connected in series in the return pipeline 104. For example, in this embodiment, the outlet flow indicator 600' is connected in series behind the station of the filter 800. The structure of the outlet flow indicator 600' is basically the same as that of the inlet flow indicator 600.

[0076] Specifically, the outlet flow indicator 600' includes a base 610, an impeller 620, a transparent cover 630, and a light-shielding top cover 640. The base 610 forms an impeller cavity 610a, which is connected to the return liquid pipeline 104. The impeller 620 is rotatably mounted on the base 610 via a rotating shaft and is located within the impeller cavity 610a. The transparent cover 630 is mounted on the base 610 to seal the impeller cavity 610a. The light-shielding top cover 630 640 is closedly mounted on the base 610 and can cover the transparent cover 630.

[0077] The base 610 is made of a light-blocking material, and the transparent cover 630 can be made of a transparent material, such as transparent plastic or transparent glass. When the liquid enters the impeller chamber 610a, due to the continuity of the liquid, it will wash over the impeller 620. The impeller 620 rotates under the action of the flowing liquid. By observing whether the impeller 620 is rotating through the transparent cover 630, it can be determined whether the liquid is in a flowing state.

[0078] Impeller 620 is eccentrically positioned relative to impeller cavity 610a to accommodate lower flow rates. When a flow indicator is applied to a bladder circulation hyperthermic irrigation device, the flow rate in the tubing system during treatment is typically between 50 ml / min and 200 ml / min, and in most cases below 150 ml / min. Such a speed is relatively slow, thus requiring increased sensitivity of impeller 620 rotation.

[0079] Please see Figure 2The intracavitary hot perfusion circulation pipeline 10 also includes a flow regulating valve 900, which is connected in series in the return pipeline 104. For example, in this embodiment, the flow regulating valve 900 is located behind the outlet flow indicator and is used to regulate the flow rate of the medicine in the return pipeline 104.

[0080] Specifically, the inlet tubing 101, outlet tubing 102, pre-filling tubing 103, cavity inlet tubing 105, cavity outlet tubing 106, and return tubing 104 can all be made of flexible tubing made of soft material. The tubing can also have light-shielding properties to meet the requirements of some bladder chemotherapy drugs that need to be administered in the dark.

[0081] The two-way valve 400, dosing connector 500, pressure testing assembly 300, inlet flow indicator 600, inlet temperature sensor 700, outlet temperature sensor 700', filter 800, outlet flow indicator 600', and flow regulating valve 900 can all be connected in series in the pipeline system through a purely physical connection method using connector 20 and locking sleeve 30 to prevent adhesive residue.

[0082] Specifically, a channel 20a is formed on the connector 20, through which liquid communicates with the piping system. The connector 20 includes a mating section 21 and a connecting section 22. A first protrusion 23 is formed on the outer wall of the mating section 21, and the outer wall of the connecting section 22 is a conical surface. The locking sleeve 30 includes a first locking section 31 and a second locking section 32. A second protrusion 33 is formed on the inner wall of the first locking section 31 to mate with the first protrusion 23. A pressing part is formed on the inner wall of the second locking section 32, and the hose is pressed between the pressing part and the connecting section 22.

[0083] When the locking sleeve 30 mates with the connector, the locking sleeve 30 is first inserted into the hose, and then one end of the hose is placed on the connecting section 22 of the connector. As the hose is pushed further into the connecting section 22, it is stretched by the connecting section 22. This causes the locking sleeve 30 to move until the second protrusion 33 on the inner wall of the first locking sleeve 30 passes the first protrusion 23 on the outer wall of the mating section 21. The pressing part on the inner wall of the second locking section 32 will have a certain pressing effect on the hose, thus pressing the hose between the connecting section 22 and the second locking section 32, preventing the hose from coming off the connector.

[0084] The above-mentioned intracavitary hot infusion circulation line 10 has at least the following advantages:

[0085] Insert the needle into the drug bag, and rotate the valve core 410 of the two-way valve 400 to open it. The drug solution in the drug bag enters the storage chamber 100a of the heating tank 100 through the inlet pipe 101. Chemotherapy drugs can also be injected into the inlet pipe 101 through the drug delivery connector 500. When the amount of drug solution in the heating tank 100 reaches the set value, close the two-way valve 400, and close the inlet pipe 101. The drug solution in the heating tank 100 is then preheated by the electromagnetic induction heating device until the preheating temperature is reached.

[0086] The pre-fill valve 1031 is opened, and the inlet valve 1051 and outlet valve 1061 are closed. The medication is drawn from the storage chamber 100a by the circulating pump 200. An external pressure sensor connected to the pressure measuring component 300 measures the pressure of the liquid in the outlet pipeline 102. The medication passes through the inlet flow indicator 600 and inlet temperature sensor 700 on the outlet pipeline 102 before entering the pre-fill pipeline 103. Then, it flows back to the heating tank 100 via the outlet temperature sensor 700', filter 800, outlet flow indicator 600', and flow regulating valve 900 on the return pipeline 104. The medication flows back to the heating tank 100 via the outlet pipeline 102, pre-fill pipeline 103, and return pipeline 104, thus pre-purging air from the pipeline system to prevent inflammation.

[0087] Then, the pre-fill valve 1031 is closed, and the inlet valve 1051 and outlet valve 1061 are opened. Under the action of the circulation pump 200, the medicine is drawn out of the storage chamber 100a again, enters the bladder through the outlet line 102 and the inlet line 105, and then flows out of the bladder, flowing back to the heating tank 100 through the outlet line 106 and the return line 104. During the circulation of the medicine, the heating tank 100 can continuously heat the medicine until the set temperature is reached, achieving the purpose of circulating and heating at the same time, so as not to cause the medicine temperature to rise rapidly at the beginning and avoid bladder contraction or spasm.

[0088] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. An intracavitary hot infusion circulation pipeline, characterized in that, include: The heating tank is hollow to form a liquid storage cavity, which is used to store the medicine liquid. The liquid inlet pipe has one end connected to the liquid storage chamber and the other end connected to the medicine bag; One end of the liquid outlet pipe is connected to the liquid storage chamber; A circulation pump, connected in series with the liquid outlet pipeline, is used to extract the liquid medicine from the storage chamber; The pre-filling pipeline is connected at one end to the other end of the liquid outlet pipeline; The return line is connected at one end to the other end of the pre-filling line and at the other end to the liquid storage chamber. An inlet tube, one end of which is connected to the other end of the outlet tube, and the other end is used to connect to the body cavity; and The outlet tubing has one end connected to the body cavity and the other end connected to one end of the return tubing. The pre-filling tubing is connected in parallel with the inlet tubing and the outlet tubing. Also includes: An outlet temperature sensor is connected in series in the return liquid pipeline. The outlet temperature sensor includes a second liquid storage shell, a third temperature measuring component, a first outlet end cap, and a second outlet end cap. The second liquid storage shell is hollow to form a second liquid storage chamber. The first outlet end cap covers the liquid outlet end of the second liquid storage shell, and the second outlet end cap is located at the liquid inlet end of the second liquid storage shell. The second outlet end cap has a second liquid inlet through hole connecting the second liquid storage chamber and the return liquid pipeline. The cross-sectional area of ​​the second liquid storage chamber is larger than the cross-sectional area of ​​the return liquid pipeline. The third temperature measuring component includes a third hollow tube and a third temperature sensor. The third hollow tube extends into the second liquid storage chamber from the first outlet end cap and is adjacent to the second liquid inlet through hole. The third temperature sensor has a third probe end that extends into the third hollow tube and is located at the end of the third hollow tube near the second liquid inlet through hole.

2. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The intracavitary hot infusion circulation pipeline includes an outlet flow indicator, which is connected in series in the return pipeline. The outlet flow indicator includes a base, an impeller, and a transparent cover. The base forms an impeller cavity, which is connected to the return pipeline. The impeller is rotatably mounted on the base via a rotating shaft and is located inside the impeller cavity. The transparent cover is mounted on the base to seal the impeller cavity. The impeller is eccentrically positioned relative to the impeller cavity.

3. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The intracavitary hot infusion circulation pipeline includes an outlet flow indicator, which is connected in series in the return pipeline. The outlet flow indicator includes a base, an impeller, and a transparent cover. The base forms an impeller cavity, which is connected to the return pipeline. The impeller is rotatably mounted on the base via a rotating shaft and is located inside the impeller cavity. The transparent cover is mounted on the base to seal the impeller cavity. The outlet flow indicator also includes a light-shielding cover, which is disposed on the base and can cover the transparent cover.

4. The intracavitary hot infusion circulation pipeline according to claim 3, characterized in that, The base is made of light-shielding material, and the liquid inlet pipe, the liquid outlet pipe, the pre-filling pipe, the cavity inlet pipe, the cavity outlet pipe, and the liquid return pipe are all flexible tubes made of soft material with light-shielding properties.

5. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The liquid inlet end of the second liquid storage shell is the second small diameter end, and the liquid outlet end of the second liquid storage shell is the second large diameter end. The inner diameter of the second small diameter end is smaller than the inner diameter of the second large diameter end.

6. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The third probe end is positioned directly opposite the second liquid inlet hole.

7. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The heating tank includes a tank body and a cover. The tank body is hollow and has an opening at one end. The cover is placed on the opening of the tank body. The cover and the tank body together form the liquid storage cavity. The tank body is used to be placed on an electromagnetic induction heating device. The electromagnetic induction heating device is used to heat the tank body to indirectly heat the liquid in the liquid storage cavity.

8. The intracavitary hot infusion circulation pipeline according to any one of claims 1 to 7, characterized in that, Also includes: A filter, connected in series in the return liquid pipeline, includes a housing, a filter element, an upper cover, and a lower cover. The housing forms a filter element cavity, which is connected to the return liquid pipeline. The filter element is housed within the filter element cavity and is used to filter the drug solution. The upper cover is located at one end of the housing, and the lower cover is located at the other end of the housing; and / or A flow regulating valve is connected in series in the return liquid pipeline, and the flow regulating valve is used to regulate the flow rate of the medicine liquid in the return liquid pipeline.

9. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The intracavitary hot infusion circulation pipeline includes a filter, an outlet flow indicator, and a flow regulating valve. The filter is connected in series in the return liquid pipeline. The filter includes a housing, a filter element, an upper cover, and a lower cover. The housing forms a filter element cavity, which is connected to the return liquid pipeline. The filter element is housed in the filter element cavity and is used to filter the drug solution. The upper cover is disposed at one end of the housing, and the lower cover is disposed at the other end of the housing. The outlet flow indicator is connected in series in the return liquid pipeline. The outlet flow indicator includes a base, an impeller, and a transparent cover. The base forms an impeller cavity, which is connected to the return liquid pipeline. The impeller is rotatably mounted on the base via a rotating shaft and is located inside the impeller cavity. The transparent cover is mounted on the base to seal the impeller cavity. The flow regulating valve is connected in series in the return liquid pipeline, and the flow regulating valve is used to regulate the flow rate of the medicine liquid in the return liquid pipeline; Along the flow direction of the liquid medicine, the outlet temperature sensor is located in front of the filter, the outlet flow indicator, and the flow regulating valve, and behind the pre-filling pipeline.

10. The intracavitary hot infusion circulation pipeline according to claim 1, characterized in that, The intracavitary hot infusion circulation pipeline includes a filter, an outlet flow indicator, and a flow regulating valve. The filter is connected in series in the return liquid pipeline. The filter includes a housing, a filter element, an upper cover, and a lower cover. The housing forms a filter element cavity, which is connected to the return liquid pipeline. The filter element is housed in the filter element cavity and is used to filter the drug solution. The upper cover is disposed at one end of the housing, and the lower cover is disposed at the other end of the housing. The outlet flow indicator is connected in series in the return liquid pipeline. The outlet flow indicator includes a base, an impeller, and a transparent cover. The base forms an impeller cavity, which is connected to the return liquid pipeline. The impeller is rotatably mounted on the base via a rotating shaft and is located inside the impeller cavity. The transparent cover is mounted on the base to seal the impeller cavity. The flow regulating valve is connected in series in the return liquid pipeline, and the flow regulating valve is used to regulate the flow rate of the medicine liquid in the return liquid pipeline; Along the flow direction of the liquid medicine, the filter is located in front of the outlet flow indicator and the flow regulating valve, and behind the outlet temperature sensor.

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