Application of the uniform lily rehmannia polysaccharide in the preparation of drugs for treating cerebral ischemia
By preparing and purifying homogeneous polysaccharides from Lilium and Rehmannia glutinosa, and utilizing them to regulate cGAS-STING signal transduction, the shortcomings of ischemic stroke treatment were addressed, achieving effective neuroprotection against cerebral ischemia-reperfusion injury and promoting the industrialization and application of traditional Chinese medicine.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HENAN UNIV OF CHINESE MEDICINE
- Filing Date
- 2023-11-07
- Publication Date
- 2026-07-24
AI Technical Summary
There is a lack of effective treatment options for neurological complications caused by ischemic stroke (IS). Existing drug treatments have a narrow therapeutic window and are not very effective. There is also a lack of research on the application of traditional Chinese medicine in the field of cerebral ischemia, which limits the industrialization and application of lily and rehmannia polysaccharide.
A homogeneous polysaccharide composed of galactose, glucose, and fructose in a specific ratio was prepared to protect brain tissue from ischemic damage by regulating cGAS-STING signal transduction. After extraction and purification, the homogeneous polysaccharide was used as a drug for treating cerebral ischemia.
The homogeneous polysaccharide of Lilium argenteum exhibits neuroprotective effects in regulating cGAS-STING signal transduction, significantly improving cerebral ischemia-reperfusion injury, and promoting the industrialization process and application scope of Lilium argenteum.
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Figure CN117618458B_ABST