A Chinese medicine composition for treating diabetic cognitive dysfunction and preparation method thereof

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and relates to a Chinese medicine composition and preparation method for treating diabetic cognitive dysfunction. The raw materials of the Chinese medicine composition include astragalus, atractylodes, polygonatum, kudzu root, coptis root, wolfberry fruit, phellodendron, schisandra chinensis, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, rhodiola, ginseng, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, litchi seed. The Chinese medicine composition selects prescriptions and medications based on the principles of strengthening the spleen and replenishing qi, nourishing the heart and nourishing the kidney, treating both the symptoms and the root cause, taking both deficiency and excess into consideration, and can play an active therapeutic role in diabetic cognitive dysfunction. The Chinese medicine composition provided by the present invention can improve the patient's cognitive ability to treat the symptoms, control the progression of diabetes to treat the root cause, improve the patient's living standard, delay the disease, and improve the patient's quality of life on the basis of improving the fundamental constitution of patients with diabetic cognitive dysfunction.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating diabetic cognitive dysfunction and a preparation method thereof. Background Art

[0002] Diabetic cognitive dysfunction (DCD) is one of the common complications of diabetes. In recent years, the incidence of T2DM has been increasing. With the rapid development of medicine today, in addition to paying attention to the life and health of patients, the quality of life of patients should also be gradually paid attention to: such central nervous system complications caused by hyperglycemia cause certain damage to patients' memory, logical thinking ability, and reaction ability, posing a threat to patients' physical health and quality of life. There is no clear definition of diabetic cognitive dysfunction in Chinese doctors and ancient books of all dynasties, but according to its clinical manifestations and symptoms such as memory loss and cognitive decline caused by increased blood sugar, it can be classified as a category of "Xiao Ke" combined with "forgetfulness", "dementia", "forgetfulness", "dementia", "stupidity", "literary stupidity" and so on in traditional Chinese medicine. A large number of previous studies have shown that long-term poor blood sugar control can affect the cognitive decline of diabetic patients. The abnormality of cognitive function in diabetic patients is 1.5 times that of non-diabetic patients, and the earlier the age of onset, the higher the risk of dementia; the longer the duration of hyperglycemia, the more obvious the cognitive impairment. The main clinical manifestations of diabetic cognitive dysfunction are slow thinking, decreased memory, unclear logic, poor learning ability, etc., which may affect the daily work and life of diabetic patients in the long run. In recent years, with the increasing number of diabetic patients year by year, the base of people at high risk of diabetes has also gradually increased, and research related to diabetic cognitive dysfunction has gradually attracted attention and attention.

[0003] At present, the main Western medical treatments for diabetic cognitive dysfunction include: blood sugar control drugs, cerebral circulation improvers, brain metabolism improvers, etc. At present, there is no specific Western medicine for this disease, and the long-term use of Western medicine has many disadvantages, which will cause damage to the patient's liver and kidney function, and has a high safety hazard for the elderly who have long-term underlying diseases; the effect of traditional Chinese medicine treatment for diabetic cognitive dysfunction is poor; therefore, the present invention aims to improve the quality of life of patients with diabetic cognitive dysfunction, improve the survival level, and provide new ideas and prescriptions of traditional Chinese medicine for the treatment of this disease. Summary of the invention

[0004] The invention provides a Chinese medicine composition for treating diabetic cognitive dysfunction and a preparation method thereof, so as to solve the problem of poor therapeutic effect of existing Chinese medicine preparations for treating diabetic cognitive dysfunction.

[0005] A traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials of the traditional Chinese medicine composition include astragalus, atractylodes, polygonatum, kudzu root, coptis, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, anemarrhena, ginseng, gardenia, polygonum cuspidatum, calamus, ginkgo leaf, bamboo leaf and litchi seed.

[0006] In a traditional Chinese medicine composition for treating diabetic cognitive dysfunction provided in the present application, the raw materials of the traditional Chinese medicine composition include, by weight, 15-45 parts of astragalus, 5-25 parts of atractylodes, 15-45 parts of polygonatum, 5-25 parts of kudzu root, 5-25 parts of coptis, 5-25 parts of wolfberry, 5-25 parts of phellodendron, 5-25 parts of schisandra, 15-45 parts of salvia, 5-25 parts of rhodiola, 5-25 parts of cnidium, 5-25 parts of anemarrhena, 5-25 parts of ginseng, 5-25 parts of gardenia, 5-25 parts of knotweed, 15-45 parts of calamus, 5-25 parts of ginkgo leaf, 5-25 parts of bamboo leaf, and 5-25 parts of litchi seed.

[0007] Preferably, the raw materials of the traditional Chinese medicine composition include 20-40 parts of astragalus, 10-20 parts of atractylodes, 20-40 parts of polygonatum, 10-20 parts of kudzu root, 10-20 parts of coptis, 10-20 parts of wolfberry, 10-20 parts of phellodendron, 10-20 parts of schisandra, 10-20 parts of salvia, 10-20 parts of rhodiola, 10-20 parts of cnidium, 10-20 parts of anemarrhena, 10-20 parts of ginseng, 10-20 parts of gardenia, 10-20 parts of knotweed, 20-40 parts of calamus, 10-20 parts of ginkgo leaf, 10-20 parts of bamboo leaf, and 10-20 parts of litchi seed.

[0008] Most preferably, the raw materials of the Chinese medicine composition include 30 parts of astragalus, 15 parts of atractylodes, 30 parts of polygonatum, 15 parts of kudzu root, 15 parts of coptis, 15 parts of wolfberry, 15 parts of phellodendron, 15 parts of schisandra, 15 parts of salvia, 15 parts of rhodiola, 15 parts of cnidium, 15 parts of anemarrhena, 15 parts of ginseng, 15 parts of gardenia, 15 parts of knotweed, 30 parts of calamus, 15 parts of ginkgo leaves, 15 parts of bamboo leaves, and 15 parts of litchi seeds.

[0009] The present application provides a method for preparing a Chinese medicine composition for treating diabetic cognitive dysfunction, which specifically comprises the following steps:

[0010] S01: Crush and sieve the ginseng for later use.

[0011] S02: Mix Astragalus, Atractylodes, Polygonatum, Pueraria, Coptis, Lycium barbarum, Phellodendron, Schisandra, Salvia miltiorrhiza, Rhodiola rosea, Cnidium monnieri, Anemarrhena asphodeloides, Gardenia jasminoides, Polygonum cuspidatum, Acorus calamus, Ginkgo biloba, Bambusa longifolia and Litchi seed, add to 70% ethanol, reflux and extract three times, and combine the three extracts into filtrate A.

[0012] S03: The filtrate A is decompressed, ethanol is recovered, and concentrated to obtain a thick paste A.

[0013] S04: The ginseng in S01 was added into 70% ethanol and refluxed for extraction three times, and the three extracts were combined into filtrate B.

[0014] S05: The filtrate B is decompressed, ethanol is recovered, and concentrated to obtain a thick paste B.

[0015] S06: The thick paste A and the thick paste B are combined and spray-dried, and auxiliary materials are added to granulate and dry to obtain a Chinese medicine granule preparation.

[0016] Furthermore, the S01 specifically comprises crushing the prepared ginseng into fine powder, and sieving the crushed ginseng through a 100-mesh sieve for later use.

[0017] Furthermore, in the S02, the amount of ethanol added with a mass concentration of 70% is 8 times the total weight of astragalus, atractylodes, polygonatum, kudzu root, coptis, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, anemarrhena, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, and litchi kernel, and the time for each reflux extraction is 2 hours.

[0018] Furthermore, in the S03, the concentration temperature is 60°C, and the relative concentration of the thick paste A is 1.18-1.23.

[0019] Furthermore, in S04, the amount of ethanol added with a mass concentration of 70% is 8 times the total weight of ginseng, and the time for each reflux extraction is 2 hours.

[0020] Furthermore, in the S05, the concentration temperature is 60°C, and the relative concentration of the thick paste B is 1.18-1.23.

[0021] Furthermore, in S06, the auxiliary material is calcium carbonate.

[0022] Among them, each Chinese medicine component has the following characteristics in the Chinese medicine composition:

[0023] Astragalus: sweet in taste, slightly warm in nature. It has the effects of replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and expelling pus, and healing sores and promoting tissue regeneration. It is mainly used to treat qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, internal heat and thirst, sallow complexion due to blood deficiency, hemiplegia, pain and numbness, carbuncle that is difficult to heal, and carbuncle that does not heal for a long time.

[0024] Atractylodes macrocephala: sweet, bitter, warm in nature. It has the effects of tonifying qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating and calming the fetus. It is mainly used to treat spleen deficiency, poor appetite and fatigue, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, leucorrhea, spontaneous sweating due to qi deficiency, and restless fetal movement due to spleen deficiency.

[0025] Polygonatum sibiricum: sweet in taste, neutral in nature. It has the effects of replenishing qi and yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys. It is mainly used to treat spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, dry cough due to lung deficiency, cough due to fatigue and hemoptysis, insufficient essence and blood, soreness of waist and knees, premature graying of hair, internal heat and thirst.

[0026] Pueraria root: sweet, spicy, cool in nature. It has the effects of relieving muscle and fever, promoting body fluid and quenching thirst, clearing rashes, raising yang and stopping diarrhea, promoting blood circulation and activating collaterals, and detoxifying alcohol. It is mainly used to treat exogenous fever and headache, stiff neck and back pain, thirst due to fever, thirst, measles that does not clear up, hot diarrhea and dysentery, diarrhea due to spleen deficiency, hemiplegia due to stroke, chest pain and heartache, dizziness and headache, and alcohol poisoning.

[0027] Coptis chinensis: bitter in taste, cold in nature. It has the effects of clearing away heat and dampness, purging fire and detoxifying. It is mainly used to treat damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, palpitations, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle, furuncle.

[0028] Lycium barbarum: sweet in taste, neutral in nature. It nourishes the liver and kidneys, improves the essence and eyesight. It is mainly used to treat liver and kidney yin deficiency, deficiency of essence and blood, soreness of waist and knees, dizziness and tinnitus, impotence and spermatorrhea, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.

[0029] Phellodendron chinense: bitter in taste, cold in nature. It has the effects of clearing away heat and dampness, purging fire and detoxifying, and removing bone steaming. It is mainly used to treat damp-heat diarrhea, jaundice and red urine, vaginal itching, hot and painful stranguria, bone steaming and fatigue fever, night sweats, spermatorrhea, sores and swelling, eczema and wet sores.

[0030] Schisandra chinensis: sour, sweet, warm in nature. It has the effects of invigorating qi and promoting body fluid, nourishing the kidney and calming the mind. It is mainly used to treat chronic cough, weak asthma, nocturnal emission, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirst due to loss of body fluid, internal heat and thirst, palpitations and insomnia.

[0031] Danshen: bitter, slightly cold. It has the effects of promoting blood circulation and removing blood stasis, relieving pain, clearing the heart and relieving vexation, cooling blood and eliminating carbuncle. It is mainly used to treat irregular menstruation due to blood stasis, dysmenorrhea, amenorrhea, abdominal pain after childbirth, chest pain due to blood stasis, pain in the abdomen and ribs, accumulation of lumps and masses, injuries from falls, pain due to heat arthralgia, and swelling and pain due to sores and carbuncle.

[0032] Rhodiola rosea: sweet, bitter, neutral in nature. It has the effects of invigorating qi and activating blood circulation, unblocking meridians and relieving asthma. It is mainly used to treat qi deficiency and blood stasis, chest pain and heart pain, hemiplegia caused by stroke, lung and spleen deficiency, fatigue and asthma.

[0033] Cnidium monnieri: pungent, bitter, warm in nature. It has the effects of drying dampness and dispelling wind, killing insects and relieving itching, warming the kidney and strengthening yang. It is mainly used to treat impotence due to kidney deficiency, infertility due to cold uterus, leucorrhea due to cold and dampness, and low back pain due to dampness.

[0034] Anemarrhena: bitter, sweet, cold in nature. It has the effects of clearing away heat and purging fire, nourishing yin and moistening dryness. It is mainly used to treat exogenous febrile diseases, high fever and thirst, cough due to lung heat, dry cough due to yin deficiency, bone steaming and hot flashes, internal heat and thirst, and constipation due to yin deficiency and dry intestines.

[0035] Ginseng: sweet, slightly bitter, slightly warm in nature. It has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, nourishing spleen and lung, promoting body fluid and nourishing blood, calming the mind and improving intelligence. It is mainly used to treat qi deficiency and weakness, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and cough, impotence and cold uterus, thirst due to qi deficiency and loss of body fluid, internal heat and thirst, qi and blood deficiency, long-term illness and weakness, insufficient heart qi, palpitations and insomnia.

[0036] Gardenia: bitter in taste, cold in nature. It has the effects of purging fire and relieving restlessness, clearing away heat and dampness, cooling blood and detoxifying, and externally reducing swelling and relieving pain. It is mainly used to treat fever, damp-heat jaundice, stranguria and pain, vomiting and bleeding due to blood heat, red and swollen eyes, hot and toxic sores, and sprains and pains.

[0037] Polygonum cuspidatum: bitter, slightly cold in nature. It has the effects of promoting dampness and relieving jaundice, clearing away heat and detoxifying, dispersing blood stasis and relieving pain, resolving phlegm and relieving cough, purging heat and relieving constipation. It is mainly used to treat damp-heat jaundice, stranguria, leucorrhea, carbuncle, burns, snake bites, amenorrhea, abdominal masses, rheumatic pain, traumatic injury, and lung heat cough.

[0038] Acorus calamus: pungent, bitter, warm in nature. It has the effects of opening the orifices and dispelling phlegm, refreshing the mind and improving intelligence, removing dampness and harmonizing the stomach. It is mainly used to treat phlegm blocking the orifices, coma and epilepsy, forgetfulness and insomnia, tinnitus and deafness, dampness blocking the middle jiao, abdominal distension without hunger, and dysentery with lockjaw.

[0039] Ginkgo biloba: dry, bitter, astringent, neutral in nature. It has the effects of promoting blood circulation and removing blood stasis, dredge meridians and relieve pain, astringe the lungs and relieve asthma, remove turbidity and reduce fat. It is mainly used to treat blood stasis blocking meridians, chest pain and heart pain, hemiplegia caused by stroke, cough and asthma caused by lung deficiency, and hyperlipidemia.

[0040] Bamboo leaves: sweet, spicy, light, cold in nature. It has the effects of clearing away heat and purging fire, relieving restlessness, promoting body fluid and promoting diuresis. It is mainly used to treat fever, thirst, mouth sores, and short, red and painful urination.

[0041] Litchi kernel: sweet, slightly bitter, warm in nature. It has the effects of promoting qi and dispersing stagnation, dispelling cold and relieving pain. It is mainly used to treat abdominal pain caused by cold hernia, testicular swelling and pain, epigastric distension and pain, dysmenorrhea, and abdominal pain after childbirth.

[0042] Compared with the prior art, the present invention has the following beneficial effects.

[0043] The present invention provides a Chinese medicine composition for treating diabetic cognitive dysfunction and a preparation method thereof. The raw materials for preparing the Chinese medicine composition include astragalus, atractylodes, polygonatum, kudzu root, coptis root, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, rhodiola, ginseng, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, and litchi seed. The Chinese medicine composition is based on the principle of "strengthening the spleen and replenishing qi, nourishing the heart and nourishing the kidney" to treat diabetic cognitive dysfunction. In clinical practice, we found that the disease location of patients with diabetic cognitive dysfunction is in the brain, but its pathogenesis is inseparable from the spleen, heart, and kidney. This disease should be a syndrome of deficiency in the root and excess in the superficial. Its cause is mostly dysfunction of viscera, which causes thirst. In addition, due to long-term illness, pathological products such as phlegm and blood stasis block the brain network, resulting in the failure of clear yang to rise; the fluctuation disorder of blood sugar and poor control of body weight lead to the generation of sugar toxicity and lipid toxicity, which further aggravates the occurrence and development of this disease. The pathological characteristics of diabetic cognitive dysfunction are mostly deficiency of the root and excess of the symptoms. The symptoms are changes in cognitive function, and the root is damage to the nervous system caused by long-term hyperglycemia. The treatment principle is to strengthen the spleen and replenish qi, nourish the heart and nourish the kidneys, and treat the symptoms and the root at the same time to improve the current symptoms, delay the progression of the disease, and relieve the patient's pain. The Chinese medicine composition in this application targets its pathogenesis, takes strengthening the spleen and replenishing qi, nourishing the heart and nourishing the kidneys as the main treatment method, and plays a positive role in improving the patient's clinical symptoms, hormone levels, physical conditioning and other aspects.

[0044] The astragalus in the prescription has the effects of replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and draining pus, and healing sores and promoting tissue regeneration. Its main component is astragalus polysaccharide, which can not only reduce blood sugar, but also resist oxidative stress and apoptosis, enhance the activity of SOD in hippocampal tissue, and reduce the content of MDA. Salidroside, the active ingredient in Rhodiola rosea, also has similar effects. Coptis chinensis and Acorus tatarinowii both enter the heart and stomach meridians. Coptis chinensis is widely used in the treatment of diabetes in ancient prescriptions. In modern pharmacological studies, it shows good effects in lowering blood sugar, improving IR, and regulating glucose and lipid metabolism disorders; Acorus tatarinowii can not only resist aging, anti-oxidation and regulate blood lipids, but also has the effects of improving intelligence and protecting the brain, improving learning and memory ability and improving cognitive function, reducing neuronal damage and neuronal apoptosis, and protecting the nervous system. Studies have shown that berberine, coptisine, epiberberine, palmatine and β-asarone in the drug pair Rhizoma Coptidis-Acorus Tatarinowii may be potential pharmacological substances of the Rhizoma Coptidis-Acorus Tatarinowii components for preventing and treating diabetic cognitive dysfunction, which can regulate blood sugar and blood lipid levels, improve IR and oxidative stress, reduce Aβ deposition, inhibit neuronal cell apoptosis and neuronal damage, and have anti-cognitive effects. Gardenia enters the heart meridian and has the effects of purging fire and relieving restlessness, clearing heat and removing dampness, cooling blood and detoxifying, and external use to reduce swelling and relieve pain. Its active ingredient, gardenia glycoside, can reduce blood sugar in multiple ways by mimicking cholecystokinin, protecting pancreatic β cells, and activating the glucagon-like peptide 1 (GLP-1) receptor signaling pathway; the natural compound geniposide extracted from the fruit of Gardenia jasminowii can improve the neuropathological damage of Alzheimer's disease by downregulating mTOR signaling, enhancing the autophagy and lysosomal clearance of β fibrils. Total alkaloids of Coptis chinensis, salidroside, astragalus polysaccharide, and Cnidium monnieri extract can improve blood sugar levels and enhance SOD activity in hippocampal tissue of models, reduce MDA content, inhibit oxidative stress response, and delay further damage to cognitive function. Litchi seed extract can effectively prevent the hyperphosphorylation of Tau protein while lowering blood sugar and improving insulin resistance, thereby improving cognitive dysfunction. Ginsenosides, the active ingredient of ginseng, also have similar effects. The drug pair Anemarrhena asphodeloides-Phellodendron chinense can accelerate the clearance of Aβ1-42, and the active ingredient of Anemarrhena asphodeloides, total saponins of Anemarrhena asphodeloides, can also reduce TNF-α levels to intervene in inflammatory responses.

[0045] The selection of coptis root, phellodendron, and gardenia is adapted from Huanglian Jiedu Decoction, which can clear away heat and moisten dryness, especially reduce heart fire, so bamboo leaves and ginkgo leaves are added; astragalus, white atractylodes, polygonatum, wolfberry, kudzu root, schisandra chinensis, and coptis root are taken from Professor Shi Yan's classic prescription Yitangkang, which nourishes yin and clears heat from the spleen, and replenishes qi and activates blood circulation. Because cognitive impairment is mostly caused by insufficient kidney essence and malnutrition of brain marrow, so on the basis of clearing heart fire and replenishing spleen qi, products that can refresh the mind and benefit the mind or drugs that enter the kidney meridian are added, such as calamus, phellodendron, anemarrhena, and ginseng. Salvia miltiorrhiza and Polygonum cuspidatum can dissipate blood stasis, dredge collaterals, and remove phlegm and blood stasis. The whole prescription has the effect of strengthening the spleen and replenishing qi, nourishing the heart and nourishing the kidney.

[0046] Therefore, the Chinese medicine composition in this application can effectively treat diabetic cognitive dysfunction. It has the function of regulating blood sugar levels in diabetic patients, improving insulin resistance, delaying further nerve damage, regulating the overall function of patients, improving the quality of life of patients, and improving the living standards of patients in the future. There is no specific medicine for the treatment of diabetic cognitive dysfunction in modern medicine, and there are many disadvantages of existing drugs, such as the dosage of drugs is not easy to control, toxic and side effects, and the liver and kidney function of patients, especially those with underlying diseases, are greatly damaged, and the Chinese medicine composition in this application is safe and effective, and treats the root cause. DETAILED DESCRIPTION

[0047] The following describes the Chinese medicine composition and preparation method for treating diabetic cognitive dysfunction provided by the present application in the form of specific examples, but this does not limit the scope of protection of the present application.

[0048] Example 1.

[0049] A traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 30 parts of astragalus, 15 parts of atractylodes, 30 parts of polygonatum, 15 parts of kudzu root, 15 parts of coptis root, 15 parts of wolfberry, 15 parts of phellodendron, 15 parts of schisandra, 15 parts of salvia, 15 parts of rhodiola, 15 parts of cnidium, 15 parts of anemarrhena, 15 parts of ginseng, 15 parts of gardenia, 15 parts of knotweed, 30 parts of calamus, 15 parts of ginkgo leaf, 15 parts of bamboo leaf, and 15 parts of litchi seed.

[0050] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, the method comprising:

[0051] S101: crushing the prepared ginseng into fine powder, and sieving the crushed ginseng through a 100-mesh sieve for later use;

[0052] S102: Mix the prepared astragalus, atractylodes, polygonatum, kudzu root, coptis root, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, anemarrhena, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, and litchi seed, and then add them to an ethanol solution with a mass concentration of 70% for reflux extraction three times, and combine the extracts of the three reflux extractions into filtrate A; wherein, during the extraction process of filtrate A, the amount of ethanol added is 8 times the total weight of astragalus, atractylodes, polygonatum, kudzu root, coptis root, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, anemarrhena, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, and litchi seed, and the time for each reflux extraction is 2h;

[0053] S103: decompressing the filtrate A to recover the ethanol solution; after the ethanol is recovered, the filtrate A is heated at 60° C. and concentrated into a thick paste A with a relative concentration of 1.18-1.23, and the thick paste A is used for later use;

[0054] S104: The crushed ginseng is added to 70% ethanol for reflux extraction three times, and the extracts of the three reflux extractions are combined into filtrate B; wherein, during the extraction of filtrate B, the amount of ethanol added is 8 times the total weight of ginseng. The time of each reflux extraction is 2 hours;

[0055] S105: decompressing the filtrate B to recover the ethanol solution. After the ethanol is recovered, the filtrate B is heated at 60°C and concentrated into a thick paste B with a relative concentration of 1.18-1.23, and the thick paste B is used for later use;

[0056] S106: After the thick paste A and the thick paste B are evenly mixed, they are spray dried, and then calcium carbonate is added to the spray dried thick paste A and thick paste B to perform a granulation process to form a granular material. After the granular material is dried, a Chinese medicine granule preparation is obtained.

[0057] Example 2.

[0058] A traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The preparation raw materials of the traditional Chinese medicine composition include, by weight, 45 parts of astragalus, 25 parts of atractylodes, 25 parts of polygonatum, 25 parts of kudzu root, 25 parts of coptis, 25 parts of wolfberry, 25 parts of phellodendron, 25 parts of schisandra, 25 parts of salvia, 25 parts of rhodiola, 25 parts of cnidium, 25 parts of anemarrhena, 25 parts of ginseng, 25 parts of gardenia, 25 parts of knotweed, 45 parts of calamus, 25 parts of ginkgo leaf, 25 parts of bamboo leaf, and 25 parts of litchi seed.

[0059] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0060] Example 3.

[0061] The embodiment of the present application provides a traditional Chinese medicine composition for treating diabetic cognitive dysfunction. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 15 parts of astragalus, 5 parts of atractylodes, 15 parts of polygonatum, 5 parts of kudzu root, 5 parts of coptis, 5 parts of wolfberry, 5 parts of phellodendron, 5 parts of schisandra, 5 parts of salvia, 5 parts of rhodiola, 5 parts of cnidium, 5 parts of anemarrhena, 5 parts of ginseng, 5 parts of gardenia, 5 parts of knotweed, 15 parts of calamus, 5 parts of ginkgo leaves, 5 parts of bamboo leaves, and 5 parts of litchi seeds.

[0062] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0063] Example 4.

[0064] The embodiment of the present application provides a traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 25 parts of astragalus, 16 parts of atractylodes, 25 parts of polygonatum, 16 parts of kudzu root, 12 parts of coptis, 16 parts of wolfberry, 16 parts of phellodendron, 16 parts of schisandra, 16 parts of salvia miltiorrhiza, 16 parts of rhodiola, 16 parts of cnidium, 16 parts of anemarrhena, 5 parts of ginseng, 16 parts of gardenia, 10 parts of knotweed, 25 parts of calamus, 18 parts of ginkgo leaves, 12 parts of bamboo leaves, and 12 parts of litchi seeds.

[0065] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0066] Example 5.

[0067] The embodiment of the present application provides a traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 40 parts of astragalus, 20 parts of atractylodes, 40 parts of polygonatum, 20 parts of kudzu root, 20 parts of coptis, 20 parts of wolfberry, 20 parts of phellodendron, 20 parts of schisandra, 20 parts of salvia miltiorrhiza, 20 parts of rhodiola, 20 parts of cnidium, 20 parts of anemarrhena, 20 parts of ginseng, 20 parts of gardenia, 20 parts of knotweed, 40 parts of calamus, 20 parts of ginkgo leaf, 20 parts of bamboo leaf, and 20 parts of litchi seed.

[0068] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0069] Example 6.

[0070] The embodiment of the present application provides a traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 20 parts of astragalus, 10 parts of atractylodes, 20 parts of polygonatum, 10 parts of kudzu root, 10 parts of coptis, 10 parts of wolfberry, 10 parts of phellodendron, 10 parts of schisandra, 10 parts of salvia miltiorrhiza, 10 parts of rhodiola, 10 parts of cnidium, 10 parts of anemarrhena, 10 parts of ginseng, 10 parts of gardenia, 10 parts of knotweed, 20 parts of calamus, 10 parts of ginkgo leaf, 10 parts of bamboo leaf, and 10 parts of litchi seed.

[0071] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0072] Example 7.

[0073] The embodiment of the present application provides a traditional Chinese medicine composition for treating cognitive dysfunction in diabetes. The raw materials for preparing the traditional Chinese medicine composition include, by weight, 21 parts of astragalus, 15 parts of atractylodes, 21 parts of polygonatum, 15 parts of kudzu root, 15 parts of coptis, 15 parts of wolfberry, 10 parts of phellodendron, 15 parts of schisandra, 15 parts of salvia, 15 parts of rhodiola, 15 parts of cnidium, 12 parts of anemarrhena, 12 parts of ginseng, 12 parts of gardenia, 12 parts of knotweed, 21 parts of calamus, 15 parts of ginkgo leaves, 12 parts of bamboo leaves, and 12 parts of litchi seeds.

[0074] Based on the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the above-mentioned embodiment of the present application, the embodiment of the present application also provides a method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction, and the specific process of the method is the same as that of Example 1.

[0075] To illustrate that the Chinese medicine composition for treating diabetic cognitive dysfunction provided in the examples of the present application can be used to treat diabetic cognitive dysfunction and has a good therapeutic effect.

[0076] Clinical case 1.

[0077] The patient is a 73-year-old female. She has a history of diabetes for more than 30 years. In the past six months, she has experienced memory loss, accompanied by confusion in speech logic, which has worsened for 1 month and has affected her daily life. She came to the hospital for systematic treatment. At the first visit: the patient was forgetful, had a slurred speech, slow reaction, fatigue, sore waist and knees, red tongue with little coating, and a deep and thin pulse. Random blood sugar: 12mmol / L. Glycated hemoglobin: 7.6%. Montreal score: 20 points. After taking 14 doses of the Chinese medicine composition provided in Example 1 of this application, the diagnostic symptoms were: the patient's symptoms were significantly improved, the tongue was pale with thin white coating, and the pulse was thin. After continuing to take 21 doses of the Chinese medicine composition provided in Example 1 of this application, the diagnostic symptoms were: there was no discomfort after taking the medicine. For several months, he insisted on taking the above by himself. After reexamination, fasting blood sugar: 5.6 mmol / LGLU-2H: 7.6 mmol / L. Glycated hemoglobin: 5.2%. Montreal score: 24 points. MMSE score: 27 points. The patient's family members said that his mental state has improved, his reaction ability has improved, his fatigue symptoms have eased, his condition has stabilized, and his blood sugar has improved significantly. The patient feels that his physical condition has improved.

[0078] Clinical case 2.

[0079] Patient, male, 68 years old. History of diabetes for 24 years, usually self-take metformin 0.5g three times a day to control blood sugar. Memory loss and forgetfulness for more than a year, now come to the doctor for systematic treatment. The patient has repeated attacks of memory loss and poor sleep due to fatigue and emotional ups and downs within a year, mainly with difficulty falling asleep and easy awakening, accompanied by slow reaction, fatigue, dizziness, tinnitus, soreness of waist and knees, dark red tongue, less moss, and deep pulse. Random blood sugar: 14.6mmol / L. Glycated hemoglobin: 8.5%. Montreal score: 23 points. After taking 14 doses of the Chinese medicine composition provided in Example 1 of the present application, the diagnosed symptoms are: the patient's memory loss symptoms improved, the tongue is pale with thin white fur, and the pulse is deep. After taking 14 doses of the Chinese medicine composition provided in Example 1 of the present application, the diagnosis symptoms were: no discomfort after taking the medicine, and for several months, he insisted on taking the above medicine. After reexamination, fasting blood sugar: 4.9mmol / L GLU-2H: 7.1 mmol / L. Glycated hemoglobin: 5.5%. Montreal score: 26 points. The patient reported that his memory and reaction ability were better than before, fatigue symptoms were relieved, sleep conditions were improved, dizziness and tinnitus symptoms were improved, the condition was stable, and blood sugar conditions were significantly improved compared with before.

[0080] Clinical case 3.

[0081] Patient, female, 76 years old. History of diabetes for 15 years, usually poor blood sugar control. Memory loss and slow reaction for more than a year, today for systemic treatment to come to the doctor. The patient has had memory loss and slow reaction for a year, and has felt worse in the past six months, slow reaction, indifferent expression, fatigue, cold limbs, sore waist and knees, good appetite, poor sleep, clear and long urine, regular stool. Dark tongue, white greasy fur, deep and thin pulse. Fasting blood sugar fluctuates about 10~14mmol / L, 2 h postprandial blood sugar fluctuates between 12~15 mmol / L; random blood sugar: 12.5mmol / L. Glycated hemoglobin: 9.2%. Montreal score: 21 points. After taking 14 doses of the Chinese medicine composition provided in Example 1 of the present application, the diagnosed symptoms are: the patient's memory loss symptoms improved, the tongue is dark, the fur is thin and white, and the pulse is thin. After taking 14 doses of the Chinese medicine composition provided in Example 1 of the present application, the diagnosis symptoms were: no discomfort after taking the medicine, and for several months, he insisted on taking the above medicine. After reexamination, fasting blood sugar: 6.6 mmol / L GLU-2H: 6.8 mmol / L. Glycated hemoglobin: 5.8%. Montreal score: 25 points. The patient reported that his memory and reaction ability were better than before, fatigue symptoms were relieved, limb symptoms were better than before, sleep conditions were improved, the condition was stable, and blood sugar conditions were better than before.

[0082] In summary, the Chinese medicine composition provided in the embodiments of the present application can effectively treat diabetic cognitive dysfunction, and has good therapeutic effect, short treatment course, low cost and simple preparation method.

[0083] Those skilled in the art will readily appreciate other embodiments of the present invention after considering the specification and practicing the disclosure of the invention herein. This application is intended to cover any variations, uses or adaptations of the present invention that follow the general principles of the present invention and include common knowledge or customary techniques in the art that are not disclosed by the present invention. The specification and examples are to be considered exemplary only, and the true scope and spirit of the present invention are indicated by the following claims.

[0084] It should be understood that relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. The present invention is not limited to the precise structure described above, and various modifications and changes can be made without departing from its scope. The scope of the present invention is limited only by the appended claims.

Claims

1. A Chinese medicine composition for treating diabetic cognitive dysfunction, characterized in that: The raw materials of the traditional Chinese medicine composition are 15-45 parts of astragalus, 5-25 parts of atractylodes, 15-45 parts of polygonatum, 5-25 parts of kudzu root, 5-25 parts of coptis, 5-25 parts of wolfberry, 5-25 parts of phellodendron, 5-25 parts of schisandra, 15-45 parts of salvia, 5-25 parts of rhodiola, 5-25 parts of cnidium, 5-25 parts of anemarrhena, 5-25 parts of ginseng, 5-25 parts of gardenia, 5-25 parts of polygonum cuspidatum, 15-45 parts of calamus, 5-25 parts of ginkgo leaf, 5-25 parts of bamboo leaf and 5-25 parts of litchi seed.

2. The Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 1, characterized in that: The raw materials of the traditional Chinese medicine composition are 20-40 parts of astragalus, 10-20 parts of atractylodes, 20-40 parts of polygonatum, 10-20 parts of kudzu root, 10-20 parts of coptis root, 10-20 parts of wolfberry, 10-20 parts of phellodendron, 10-20 parts of schisandra, 10-20 parts of salvia, 10-20 parts of rhodiola, 10-20 parts of cnidium, 10-20 parts of anemarrhena, 10-20 parts of ginseng, 10-20 parts of gardenia, 10-20 parts of polygonum cuspidatum, 20-40 parts of calamus, 10-20 parts of ginkgo leaf, 10-20 parts of bamboo leaf and 10-20 parts of litchi seed.

3. The Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 1, characterized in that: The raw materials of the traditional Chinese medicine composition are 30 parts of astragalus, 15 parts of atractylodes, 30 parts of polygonatum, 15 parts of kudzu root, 15 parts of coptis, 15 parts of wolfberry, 15 parts of phellodendron, 15 parts of schisandra, 15 parts of salvia, 15 parts of rhodiola, 15 parts of cnidium, 15 parts of anemarrhena, 15 parts of ginseng, 15 parts of gardenia, 15 parts of knotweed, 30 parts of calamus, 15 parts of ginkgo leaf, 15 parts of bamboo leaf and 15 parts of litchi seed.

4. A method for preparing a Chinese medicine composition for treating diabetic cognitive dysfunction as claimed in claim 1, characterized in that: The specific steps include: S01: Grind and sieve the ginseng for later use; S02: Mix astragalus, atractylodes, polygonatum, kudzu root, coptis root, wolfberry, phellodendron, schisandra, salvia, rhodiola, cnidium, anemarrhena, gardenia, polygonum cuspidatum, calamus, ginkgo leaf, bamboo leaf, and litchi seed, add them into 70% ethanol, reflux and extract them three times, and combine the three extracts into filtrate A; S03: the filtrate A is decompressed, ethanol is recovered, and concentrated to obtain a thick paste A; S04: The ginseng in S01 was added to 70% ethanol and refluxed for extraction three times, and the three extracts were combined into filtrate B; S05: the filtrate B is decompressed, ethanol is recovered, and concentrated to obtain a thick paste B; S06: The thick paste A and the thick paste B are combined and spray-dried, and auxiliary materials are added to granulate and dry to obtain a Chinese medicine granule preparation.

5. The method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 4, characterized in that: The S01 specifically comprises crushing the prepared ginseng into fine powder, and sifting the crushed ginseng through a 100-mesh sieve for later use.

6. The method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 4, characterized in that: In the S02, the amount of ethanol added with a mass concentration of 70% is 8 times the total weight of astragalus, atractylodes, polygonatum, kudzu root, coptis, wolfberry, phellodendron, schisandra, salvia miltiorrhiza, rhodiola rosea, cnidium monnieri, anemarrhena, gardenia, knotweed, calamus, ginkgo leaf, bamboo leaf, and litchi seed, and the time for each reflux extraction is 2 hours.

7. The method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 4, characterized in that: In the S03, the concentration temperature is 60°C, and the relative concentration of the thick paste A is 1.18-1.

23.

8. The method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 4, characterized in that: In the S04, the amount of ethanol added with a mass concentration of 70% is 8 times the total weight of ginseng, and the time of each reflux extraction is 2 hours.

9. The method for preparing the Chinese medicine composition for treating diabetic cognitive dysfunction according to claim 4, characterized in that: In the S05, the concentration temperature is 60°C, and the relative concentration of the thick paste B is 1.18-1.23.