Blood glucose regulating health composition

Abstract

The present application provides a blood sugar regulating health care composition, which utilizes the combination of effective components in the fruit pulp and seeds of Momordica balsamifera, and the effective components of Chinese herbal medicines, to help the blood sugar of type 2 diabetes patients to decrease steadily. The compound food composition contains 20-60wt% Momordica balsamifera component, 5-20wt% Momordica balsamifera seed component, 1-20wt% cinnamon component, 1-15wt% monk fruit component, and 1-10wt% licorice component. In addition, the blood sugar regulating health care composition can also regulate the comprehensive indexes of patients with high blood lipids, high cholesterol, abnormal liver metabolic enzymes, and abnormal uric acid at the same time.

Description

Technical Field

[0001] This invention relates to the technical field of health food, and in particular to a blood sugar regulating health composition that can help lower blood sugar and blood lipids. Background Technology

[0002] Type 2 diabetes is a type of diabetes and a common chronic disease in modern people. The main cause is that cells become less sensitive to insulin and develop resistance, preventing blood sugar from entering the cells. In order for blood sugar to enter the cells, the pancreas secretes more insulin, but over time, insulin resistance gradually develops, and a large amount of glucose remains in the blood, causing high blood sugar and diabetes. Common causes include genetic factors, obesity, diet, and insufficient exercise. In particular, obesity is becoming increasingly common in modern people, which may not only cause type 2 diabetes but also metabolic syndromes such as high blood pressure and high blood lipids.

[0003] There is currently no cure for type 2 diabetes, but weight loss, diet, and exercise can help control the condition. However, if diet and exercise are still insufficient to control blood sugar, then diabetes medication or insulin treatment may be necessary.

[0004] Bitter melon, scientifically known as *Momordica charantia*, is also called balsam pear, bitter melon, or bitter gourd. It belongs to the Cucurbitaceae family and the *Momordica* genus. It is a common vegetable in Asia, produced in China, Southeast Asia, and Okinawa, Japan. There are many varieties, and it is rich in nutrients, especially wild bitter melon, which contains various beneficial organic components such as essential amino acids. Compared to ordinary bitter melon, it contains higher levels of nutrients, particularly saponins, which are 2-3 times higher, and vitamin content is also 2-3 times higher. Therefore, studies have shown that wild bitter melon has medicinal and health-promoting functions such as lowering blood sugar and lipids, anti-tumor effects, preventing osteoporosis, regulating endocrine function, anti-oxidation, antibacterial properties, and enhancing human immunity.

[0005] Therefore, research on the development and application of bitter melon is receiving increasing attention. There is a strong desire to develop health foods containing bitter melon, which can be used by patients with type 2 diabetes in combination with medication to make blood sugar control more effective. Summary of the Invention

[0006] In view of this, the purpose of the present invention is to provide a blood sugar regulation health care composition, which utilizes the combination of effective ingredients in bitter melon pulp and bitter melon seeds, plus the effective ingredients of traditional Chinese medicine, to help stabilize and lower blood sugar in patients with type 2 diabetes. In addition, it can also help regulate the comprehensive indicators of patients with hyperlipidemia, hypercholesterolemia, abnormal liver metabolic enzymes, and abnormal uric acid.

[0007] Specifically, the present invention provides a blood sugar regulating health care composition, characterized in that it comprises at least: 20-60 wt% of bitter melon component; 5-20 wt% of bitter melon seed component; 1-20 wt% of cinnamon component; 1-15 wt% of monk fruit component; and 1-10 wt% of licorice component; wherein the bitter melon component contains 10 wt% bitter melon saponins; the monk fruit component contains 5 wt% mogroside V; the licorice component contains 2 wt% licorice flavonoids; and the cinnamon component contains 2 wt% cinnamaldehyde.

[0008] In one embodiment of the present invention, the bitter melon component includes at least a bitter melon extract, and the bitter melon extract is prepared as follows: a. Fresh bitter melon is washed, seeds are removed, sliced, and dried until the moisture content is below 5 wt%; b. The dried bitter melon slices are crushed through a 60-mesh sieve using a pulverizer to obtain bitter melon powder, and then the bitter melon powder is mixed with an ethanol aqueous solution with a concentration of 50-95 wt% and extracted for 60-180 minutes to obtain a bitter melon extract; c. The bitter melon extract is concentrated under reduced pressure at a temperature of 50°C and a pressure of -0.06 MPa to obtain a bitter melon concentrate; d. The bitter melon concentrate is mixed with an embedding material for embedding, and after embedding, it is dried and then crushed through a 100-mesh sieve using a pulverizer to obtain the bitter melon extract.

[0009] In one embodiment of the present invention, in step b, the weight ratio of the bitter gourd powder to the ethanol aqueous solution is between 1:10 and 1:30.

[0010] In one embodiment of the present invention, in step c, the weight ratio of the bitter gourd concentrate to the embedding material is between 1:1 and 1:10.

[0011] In one embodiment of the present invention, the bitter melon component further comprises the bitter melon powder obtained by step b.

[0012] In one embodiment of the present invention, the bitter melon seed component includes at least a bitter melon seed extract, and the bitter melon seed extract is prepared as follows: a. Bitter melon seeds are crushed using a pulverizer through a 60-mesh sieve to obtain bitter melon seed powder, and then subjected to supercritical extraction at an extraction pressure of 35 MPa and an extraction temperature of 50°C to remove the oil content of the bitter melon seed powder, so that the oil content of the bitter melon seed powder is below 1 wt%; b. The bitter melon seed powder after oil removal is extracted with pure water for 60-120 minutes to obtain a bitter melon seed extract; c. The bitter melon seed extract is concentrated under reduced pressure at a temperature of 50°C and a pressure of -0.06 MPa and then dried to obtain the dried bitter melon seed extract.

[0013] In one embodiment of the present invention, in step b, the weight ratio of the bitter gourd seed powder after oil removal to the pure water is between 1:10 and 1:30.

[0014] In one embodiment of the present invention, the monk fruit component includes at least monk fruit extract, and the method for preparing the monk fruit extract is as follows: a. Monk fruit is crushed using a pulverizer through a 60-mesh sieve to obtain monk fruit powder, and then the monk fruit powder is mixed with pure water and extracted for 60-120 minutes to obtain monk fruit extract; b. The monk fruit extract is concentrated under reduced pressure at a temperature of 50°C and a pressure of -0.06 MPa and then dried to obtain dried monk fruit extract; wherein, in step a, the weight ratio of monk fruit powder to pure water is between 1:10 and 1:30.

[0015] In one embodiment of the present invention, the monk fruit component further comprises the monk fruit powder obtained by step a.

[0016] In one embodiment of the present invention, the licorice component contains at least licorice extract, and the licorice extract is prepared as follows: a. Licorice is crushed using a pulverizer through a 60-mesh sieve to obtain licorice powder, and then the licorice powder is mixed with an aqueous ethanol solution with a concentration of 50-95 vt% and extracted for 60-120 minutes to obtain licorice extract; b. The licorice extract is mixed with an embedding material for embedding, and after embedding, it is dried, and then crushed using a pulverizer through a 100-mesh sieve to obtain the licorice extract.

[0017] In one embodiment of the present invention, in step a, the weight ratio of licorice powder to the ethanol aqueous solution is between 1:10 and 1:30; in step b, the weight ratio of licorice extract to the embedding material is between 1:1 and 1:10.

[0018] In one embodiment of the present invention, the licorice component further comprises the licorice powder obtained by step a.

[0019] In one embodiment of the present invention, the cinnamon component contains at least cinnamon extract, and the method for preparing the cinnamon extract is as follows: a. Crush cinnamon with a 60-mesh sieve using a pulverizer to obtain cinnamon powder, then mix the cinnamon powder with an aqueous ethanol solution with a concentration of 50-95 vt% and extract for 60-120 minutes to obtain cinnamon extract; b. Mix the cinnamon extract with an embedding material for embedding, dry the material after embedding, and then crush it with a 100-mesh sieve using a pulverizer to obtain the cinnamon extract.

[0020] In one embodiment of the present invention, in step a, the weight ratio of the cinnamon powder to the aqueous ethanol solution is between 1:10 and 1:30; in step b, the weight ratio of the cinnamon extract to the embedding material is between 1:1 and 1:10.

[0021] In one embodiment of the invention, the cinnamon component further comprises the cinnamon powder obtained by step a.

[0022] In one embodiment of the present invention, the embedding material is any one of whey protein, carboxymethyl cellulose, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin.

[0023] In one embodiment of the present invention, the blood sugar regulating health composition further comprises at least one of a sweetener, an excipient, a carrier, an antioxidant, and combinations thereof. Detailed Implementation

[0024] The following describes and illustrates different specific embodiments of the present invention in more detail, so as to make the spirit and content of the present invention more complete and easier to understand; however, those skilled in the art should understand that the present invention is not limited to these examples, and other identical or equivalent functions and steps can also be used to achieve the present invention.

[0025] In this document, the scientific and technical terms used have the same meaning as understood and commonly used by one of ordinary skill in the art to which this invention pertains. Furthermore, unless conflicting with the context, the singular form of a noun used herein includes its plural form, and vice versa.

[0026] In this document, the numerical values ​​and parameters used to define the scope of the invention inevitably contain standard deviations due to individual testing methods, and are therefore mostly expressed as approximate values. However, in specific embodiments, the relevant values ​​are presented as precisely as possible. In this document, "approximately" is generally used as a matter of consideration for those skilled in the art to which this invention pertains, and generally refers to an actual value falling within an acceptable standard error of the average value, for example, the actual value being within ±10%, ±5%, ±1%, or ±0.5% of a specific value or range.

[0027] In this article, the technical means of "drying" can be spray drying, hot air drying, freeze drying, or other conventional drying methods, and there is no limitation.

[0028] According to one embodiment of the present invention, the blood sugar regulating health composition of the present invention can be administered together with excipients or without excipients. Alternatively, the blood sugar regulating health composition of the present invention can be in the form of a solid tablet containing various excipients, various disintegrants, particle binders, or lubricants, or can be filled into soft or hard gelatin capsules, or can be encapsulated in a biodegradable carrier as particles.

[0029] Suitable excipients for use in this invention may, for example, be one or more of starch, dextrin, microcrystalline cellulose, sodium carboxymethyl starch, croscarmellose sodium, micronized silica, magnesium stearate, and lactose. Additionally, the blood sugar regulating health composition of this invention may also contain at least one of sweeteners, carriers, and antioxidants that are compatible with other components and the organism.

[0030] To provide a more comprehensive and complete description of the present invention, the following illustrative descriptions of embodiments and specific examples are provided; however, these are not intended to represent the only form that can be practiced or utilized in the specific examples of the invention. The embodiments cover the features and constructions of multiple specific examples, as well as the process steps and sequence of operations for these specific examples. However, in other examples, the same or equivalent functions and sequence of steps can also be used to accomplish the same task.

[0031] The blood sugar regulating health care composition of the present invention comprises bitter melon component, bitter melon seed component, monk fruit component, licorice component, and cinnamon component; wherein, the weight percentage content of the bitter melon component is generally between 20 and 60 wt%, preferably between 25 and 60 wt%, more preferably between 30 and 60 wt%, and most preferably between 35 and 60 wt%; the weight percentage content of the bitter melon seed component is generally between 5 and 20 wt%, preferably between 5 and 15 wt%, and most preferably between 8 wt%. The weight percentage content of the monk fruit component is generally between 1 and 15 wt%, preferably between 3 and 10 wt%, and most preferably between 5 and 10 wt%; the weight percentage content of the licorice component is generally between 1 and 10 wt%, preferably between 1 and 8 wt%, and most preferably between 3 and 6%; the weight percentage content of the cinnamon component is generally between 1 and 20 wt%, preferably between 5 and 15 wt%, and most preferably between 8 and 13 wt%.

[0032] According to the technical concept of the present invention, the effective components in the bitter melon component, monk fruit component, licorice component, and cinnamon component of the blood sugar regulating health care composition need to be quantitatively analyzed. For example, the bitter melon saponin content in the bitter melon component is 10wt%, the monk fruit component has a mogroside V content of 5wt%, the licorice component has a licorice flavonoid content of 2wt%, and the cinnamaldehyde content in the cinnamon component is 2wt%.

[0033] The bitter melon component generally includes bitter melon extract extracted from bitter melon pulp. It is obtained by extracting and concentrating the bitter melon concentrate using a 50-95% vol% ethanol aqueous solution, and then encapsulating it with an encapsulating material. The finished product obtained by encapsulation with the encapsulating material can increase water solubility and human bioavailability.

[0034] According to the technical concept of the present invention, the weight ratio of the bitter gourd powder to the ethanol aqueous solution is between 1:10 and 1:30; preferably between 1:10 and 1:25; and more preferably between 1:10 and 1:20.

[0035] According to the technical concept of the present invention, the encapsulating material can be any one of whey protein, carboxymethyl cellulose, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin; preferably any one of whey protein, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin; more preferably any one of whey protein, gum arabic, chitosan, cyclodextrin, and gelatin; and most preferably any one of whey protein, chitosan, cyclodextrin, and gelatin. The weight ratio of the bitter melon concentrate to the encapsulating material is generally between 1:1 and 1:10, preferably between 1:1 and 1:8; more preferably between 1:1 and 1:5; and most preferably between 1:1 and 1:3.

[0036] Furthermore, in order to avoid the content of bitter melon saponins in the bitter melon extract exceeding the quantitative standard (10wt%), bitter melon powder can be added appropriately to the bitter melon component to adjust the content of bitter melon saponins. The source of bitter melon powder is generally the dried raw material used in the preparation of bitter melon extract.

[0037] The bitter melon seed component is usually composed of bitter melon seed extract, which is obtained by first removing the oil from the bitter melon seeds using supercritical extraction, and then using pure water extraction and vacuum concentration. Using supercritical extraction to remove the oil from the bitter melon seeds can avoid the risk of residual solvent due to conventional oil removal with organic solvents (n-hexane), while pure water extraction can obtain a high content of bitter melon protein from the bitter melon seeds.

[0038] According to the technical concept of the present invention, the weight ratio of the bitter gourd seed powder after oil removal to the pure water is between 1:10 and 1:30; preferably between 1:10 and 1:25; and more preferably between 1:10 and 1:15.

[0039] The monk fruit component is typically composed of monk fruit extract, obtained by extracting monk fruit with pure water, concentrating under reduced pressure, and then drying. According to the technical concept of this invention, the weight ratio of monk fruit to water is between 1:10 and 1:30; preferably between 1:10 and 1:25; and even more preferably between 1:10 and 1:15.

[0040] Similarly, in order to avoid the content of mogroside V in monk fruit extract exceeding the quantitative standard (5wt%), monk fruit powder can be added appropriately to the monk fruit component to adjust the content of mogroside V. The source of monk fruit powder is generally the dried raw material used in the preparation of monk fruit extract.

[0041] The licorice component is generally composed of licorice extract, which is obtained by encapsulating the licorice extract obtained by extracting it with an aqueous ethanol solution with a concentration of 50-95 wt% with an encapsulating material. The finished product obtained by encapsulation with the encapsulating material can increase water solubility and human bioavailability.

[0042] According to the technical concept of the present invention, the weight ratio of licorice to the ethanol-water solution is between 1:10 and 1:30; preferably between 1:10 and 1:25; more preferably between 1:10 and 1:15. Furthermore, the weight ratio of the licorice extract to the embedding material is generally between 1:1 and 1:10, preferably between 1:1 and 1:8; more preferably between 1:1 and 1:5; and most preferably between 1:1 and 1:3.

[0043] Similarly, in order to avoid the content of glycyrrhizin flavonoids in licorice extract exceeding the quantitative standard (2wt%), licorice powder can be added to the licorice component to adjust the content of glycyrrhizin flavonoids. The source of licorice powder is generally the dried raw material used in the preparation of licorice extract.

[0044] The cinnamon component is generally composed of cinnamon extract, which is obtained by encapsulating cinnamon extract obtained by ethanol extraction with an encapsulating material. The finished product obtained by encapsulation with the encapsulating material can increase water solubility and human bioavailability.

[0045] According to the technical concept of the present invention, the weight ratio of cinnamon to the ethanol-water solution is between 1:10 and 1:30; preferably between 1:10 and 1:25; more preferably between 1:10 and 1:15. Furthermore, the weight ratio of the licorice extract to the embedding material is generally between 1:1 and 1:10, preferably between 1:1 and 1:8; more preferably between 1:1 and 1:5; and most preferably between 1:1 and 1:3.

[0046] Similarly, in order to avoid the cinnamaldehyde content in cinnamon extract from exceeding the quantitative standard (2wt%), cinnamon powder can be added to the cinnamon component to adjust the cinnamaldehyde content. The source of cinnamon powder is generally the dried raw material used in the preparation of cinnamon extract.

[0047] The preferred embodiments of the present invention will be described in further detail below.

[0048] Preparation Example 1 - Bitter Melon Components

[0049] First, wash the fresh bitter melon, remove the seeds, slice and dry it until the moisture content of the bitter melon slices is below 5 wt%. Then, use a pulverizer to crush the dried bitter melon slices through a 60-mesh sieve to obtain bitter melon powder. Then, extract it with an ethanol aqueous solution with a concentration of 50-95 wt% for 60-180 minutes (the weight ratio of bitter melon powder to ethanol aqueous solution is 1:20) to obtain bitter melon extract.

[0050] The bitter melon extract was concentrated under reduced pressure at 50°C and -0.06 MPa. The concentrated bitter melon extract was then stirred with cyclodextrin at a weight ratio of 1:2 until the solution was homogeneous and did not separate into layers. The solution was then dried at 50°C for 18-24 hours. Finally, the solution was crushed using a pulverizer through a 100-mesh sieve to obtain the bitter melon extract.

[0051] The components of the bitter melon extract were quantitatively analyzed, and the content of bitter melon saponins in the bitter melon extract was confirmed to be 15 wt%. Then, in order to adjust the saponin content of the bitter melon component, the bitter melon powder obtained by drying and crushing the bitter melon was added and mixed with the bitter melon extract to adjust the content of bitter melon saponins in the bitter melon component to 10 wt%.

[0052] Preparation Example 2 - Bitter Melon Seed Components

[0053] Mature bitter gourd seeds are crushed using a pulverizer through a 60-mesh sieve to obtain bitter gourd seed powder. Then, supercritical fluid extraction is performed at an extraction pressure of 35 MPa and an extraction temperature of 50°C to remove the oil from the bitter gourd seed powder, so that the oil content of the bitter gourd seed powder is below 1 wt%.

[0054] The bitter melon seed powder, after oil removal, is extracted with pure water for 60-120 minutes (the weight ratio of bitter melon seed powder to pure water is 1:10) to obtain a bitter melon seed extract. The bitter melon seed extract is then concentrated under reduced pressure at 50°C and -0.06 MPa, and then spray-dried to obtain a dried bitter melon seed extract. The bitter melon seed extract can be directly used as the bitter melon seed component in the blood sugar regulation health care composition described in the following examples.

[0055] Preparation Example 3 - Components of Luo Han Guo (Monk Fruit)

[0056] The monk fruit was crushed using a pulverizer through a 60-mesh sieve to obtain monk fruit powder. Then, pure water was added and extracted for 60-120 minutes (the weight ratio of monk fruit powder to pure water was 1:10) to obtain monk fruit extract. The monk fruit extract was then concentrated under reduced pressure at a temperature of 50°C and a pressure of -0.06 MPa, and finally spray-dried to obtain dried monk fruit extract.

[0057] The components of the monk fruit extract were quantitatively analyzed, and the content of mogroside V in the monk fruit extract was confirmed to be 7.1 wt%. Then, in order to adjust the saponin content of the monk fruit components, the monk fruit powder obtained by drying and crushing the monk fruit was added and mixed with the monk fruit extract to adjust the content of mogroside V in the monk fruit components to 5 wt%.

[0058] Preparation Example 4 - Licorice Component

[0059] Licorice was crushed using a pulverizer through a 60-mesh sieve to obtain licorice powder, which was then extracted with an ethanol aqueous solution with a concentration of 50-95 vt% for 60-120 minutes (the weight ratio of licorice powder to ethanol aqueous solution was 1:10) to obtain licorice extract.

[0060] Next, the licorice extract and cyclodextrin were stirred at a weight ratio of 1:2 until the solution was homogeneous and did not separate into layers. Then, the solution was dried at 50°C for 18-24 hours and then crushed using a pulverizer through a 100-mesh sieve to obtain the licorice extract.

[0061] The components of the licorice extract were quantitatively analyzed, and the content of glycyrrhizin flavonoids in the licorice extract was confirmed to be 3.2 wt%. Then, in order to adjust the flavonoid content in the licorice component, the licorice powder obtained by drying and crushing the licorice was added and mixed with the licorice extract to adjust the glycyrrhizin flavonoid content in the licorice component to 2 wt%.

[0062] Preparation Example 5 - Cinnamon Component

[0063] Cinnamon was crushed using a pulverizer through a 60-mesh sieve, and then extracted with an aqueous ethanol solution of 50-95 wt% for 60-120 minutes (the weight ratio of cinnamon to aqueous ethanol solution was 1:10) to obtain cinnamon extract.

[0064] Next, the cinnamon extract and cyclodextrin are stirred at a weight ratio of 1:2 until the solution is homogeneous and does not separate into layers. Then, the solution is dried at 50°C for 18-24 hours and then crushed using a pulverizer through a 100-mesh sieve to obtain the cinnamon extract.

[0065] The cinnamon extract was subjected to quantitative analysis of its components, which confirmed that the cinnamaldehyde content in the cinnamon extract was 2.6 wt%. Then, in order to adjust the cinnamaldehyde content in the cinnamon component, the cinnamon powder obtained by drying and crushing cinnamon was added and mixed with the cinnamon extract to adjust the cinnamaldehyde content in the cinnamon component to 2 wt%.

[0066] Example 1

[0067] First, the bitter melon component, bitter melon seed component, monk fruit component, licorice component, and cinnamon component obtained in Preparation Examples 1 to 5 above were mixed, and the weight percentages of each component are as follows:

[0068] 35~60wt% bitter melon extract,

[0069] 8-14wt% bitter melon seed extract,

[0070] 5-10 wt% monk fruit extract,

[0071] 3-6% licorice extract,

[0072] 8-15wt% cinnamon extract,

[0073] Next, sweetener dc101 and excipient magnesium stearate are added and mixed, wherein dc101 has a weight percentage of 32.9 wt% in the blood sugar regulation health care composition and magnesium stearate has a weight percentage of 0.1 wt% in the blood sugar regulation health care composition.

[0074] The mixed blood sugar regulating health care composition is compressed into blood sugar regulating health care oral tablets with each tablet weighing 500mg using a tablet press.

[0075] The prepared blood sugar regulating oral tablets were given to 29 subjects with diabetes, hyperglycemia, or hyperlipidemia. Each subject took one tablet after each of the three daily meals. The subjects' age, physical symptoms, and number of days of administration are shown in Table 1 below.

[0076] Table 1

[0077]

[0078] Pre-meal blood glucose, glycated hemoglobin, triglycerides, total cholesterol, low-density cholesterol, high-density cholesterol, and uric acid were measured in the subjects before and after taking the medication. The results are recorded in Table 2.

[0079] Table 2 (The number 0 in the table represents that the subject did not have this indicator tested)

[0080]

[0081] Table 2 (continued)

[0082]

[0083] As shown in Table 2 above, the valid sample size for pre-meal blood glucose was 24, of which 20 (83%) showed a decreasing trend; the valid sample size for glycated hemoglobin was 11, of which 8 (73%) showed a decreasing trend; the valid sample size for triglycerides was 26, of which 21 (81%) showed a decreasing trend; the valid sample size for total cholesterol was 26, of which 16 (62%) showed a decreasing trend; the valid sample size for low-density lipoprotein cholesterol was 26, of which 12 (46%) showed a decreasing trend; the valid sample size for high-density lipoprotein cholesterol was 26, of which 12 (46%) showed an increasing trend; and the valid sample size for uric acid was 15, of which 8 (53%) showed a decreasing trend.

[0084] Furthermore, observations of blood glucose and glycated hemoglobin (HbA1c) levels during the treatment period revealed that most subjects experienced a significant decrease in pre-meal blood glucose levels after approximately 5 days of taking the oral blood glucose regulating supplement, while their HbA1c levels decreased by about 1% after approximately 15 days. This indicates that the blood glucose regulating supplement composition of this invention has a significant auxiliary effect in lowering blood sugar. With consistent use for more than 3 months, patients with prediabetes of type 2 can discontinue medication after lifestyle adjustments; and patients with type 2 diabetes for more than 20 years can reduce the need for injections and medication.

[0085] Furthermore, the changes in cholesterol and blood lipids of each subject during the course of treatment were observed. In patients with high cholesterol, cholesterol and low-density lipoprotein levels showed an initial increase followed by a decrease after about 20 to 30 days of taking the blood sugar regulating oral tablets. After taking the tablets for more than 30 days, cholesterol levels decreased significantly. In patients with high blood lipids, blood lipid levels generally showed a significant decrease after about 10 days of taking the blood sugar regulating oral tablets, and blood lipids could return to normal levels after about 3 months of taking the tablets.

[0086] As can be seen from the above results, the blood sugar regulation health care composition of the present invention can help lower blood sugar in the early stage for patients with type 2 diabetes, and then gradually achieve a stable decrease in blood sugar. At the same time, it can also help regulate the comprehensive indicators of patients with hyperlipidemia, hypercholesterolemia, abnormal liver metabolic enzymes, and abnormal uric acid.

[0087] In summary, the present invention has been illustrated with the above embodiments; however, the present invention is not limited to these embodiments. Those skilled in the art can make various modifications and alterations without departing from the spirit and scope of the present invention; for example, combining or changing the technical elements illustrated in the foregoing embodiments to create new embodiments, such embodiments are also considered part of the present invention. Therefore, the scope of protection sought in this case also includes the claims and the scope defined therein.

Claims

1. A blood sugar regulating health care composition, characterized in that, The blood sugar regulating health composition contains at least: 35~60wt% of bitter melon components; 8-14 wt% bitter melon seed components; 8-15 wt% cinnamon component; 5-10 wt% of monk fruit components; as well as 3-6 wt% licorice component; in The bitter melon component contains 10 wt% bitter melon saponins. The content of mogroside V in the monk fruit component is 5 wt%; The content of glycyrrhizin flavonoids in the licorice component is 2 wt%; The cinnamon component contains 2 wt% cinnamaldehyde; and The bitter melon seed component contains at least bitter melon seed extract, and the method for preparing the bitter melon seed extract is as follows: a. Use a crusher to crush bitter gourd seeds to obtain bitter gourd seed powder, and then perform supercritical extraction under the conditions of extraction pressure of 35 MPa and extraction temperature of 50°C to remove the oil content of the bitter gourd seed powder, so that the oil content of the bitter gourd seed powder is below 1 wt%. b. Extract the bitter gourd seed powder (after removing the oil) with pure water to obtain bitter gourd seed extract; c. The bitter melon seed extract is concentrated under reduced pressure and dried to obtain the dried bitter melon seed extract; in In step b, the weight ratio of the bitter gourd seed powder after oil removal to the pure water is between 1:10 and 1:

30. The bitter melon component contains at least one bitter melon extract, and the method for preparing the bitter melon extract is as follows: i. Wash the fresh bitter gourd, remove the seeds, slice it, and dry it until the moisture content is below 5 wt%; ii. The dried bitter melon slices are crushed using a pulverizer to obtain bitter melon powder. The bitter melon powder is then mixed with an ethanol aqueous solution with a concentration of 50-95 wt% for extraction to obtain bitter melon extract. iii. The bitter melon extract is concentrated under reduced pressure to obtain a concentrated bitter melon extract; iv. The bitter melon concentrate is mixed with the embedding material and embedded. After embedding, it is dried and then crushed using a pulverizer to obtain the bitter melon extract.

2. The blood sugar regulating health care composition according to claim 1, characterized in that, In step ii, the weight ratio of the bitter gourd powder to the ethanol aqueous solution is between 1:10 and 1:30; In step iv, the weight ratio of the bitter melon concentrate to the encapsulating material is between 1:1 and 1:

10. The embedding material is any one of whey protein, carboxymethyl cellulose, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin.

3. The blood sugar regulating health care composition according to claim 1, characterized in that... The bitter melon component further includes the bitter melon powder obtained through step ii.

4. The blood sugar regulating health care composition according to claim 1, characterized in that, The monk fruit component contains at least monk fruit extract, and the method for preparing the monk fruit extract is as follows: a. Use a crusher to crush the monk fruit to obtain monk fruit powder, then mix the monk fruit powder with pure water and extract to obtain monk fruit extract; b. The monk fruit extract is concentrated under reduced pressure and dried to obtain the dried monk fruit extract; in In step a, the weight ratio of the monk fruit powder to the pure water is between 1:10 and 1:

30.

5. The blood sugar regulating health care composition according to claim 4, characterized in that, The monk fruit component further includes the monk fruit powder obtained in step a.

6. The blood sugar regulating health care composition according to claim 1, characterized in that, The licorice component contains at least licorice extract, and the method for preparing the licorice extract is as follows: a. Glycyrrhiza is crushed using a pulverizer to obtain licorice powder, and then the licorice powder is mixed with an aqueous ethanol solution with a concentration of 50~95vt% for extraction to obtain licorice extract; b. Mix the licorice extract with the embedding material for embedding, dry the mixture after embedding, and then crush it using a pulverizer to obtain the licorice extract; in In step a, the weight ratio of licorice powder to the ethanol aqueous solution is between 1:10 and 1:30; In step b, the weight ratio of the licorice extract to the embedding material is between 1:1 and 1:

10. The embedding material is any one of whey protein, carboxymethyl cellulose, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin.

7. The blood sugar regulating health care composition according to claim 6, characterized in that, The licorice component further comprises the licorice powder obtained through step a.

8. The blood sugar regulating health care composition according to claim 1, characterized in that, The cinnamon component contains at least cinnamon extract, and the method for preparing the cinnamon extract is as follows: a. Cinnamon is crushed using a pulverizer to obtain cinnamon powder, and then the cinnamon powder is extracted with an aqueous ethanol solution with a concentration of 50~95vt% to obtain cinnamon extract; b. The cinnamon extract is mixed with the embedding material and embedded. After embedding, it is dried and then crushed using a pulverizer to obtain the cinnamon extract. in In step a, the weight ratio of the cinnamon powder to the aqueous ethanol solution is between 1:10 and 1:

30. In step b, the weight ratio of the cinnamon extract to the embedding material is between 1:1 and 1:

10. The embedding material is any one of whey protein, carboxymethyl cellulose, maltodextrin, egg yolk lecithin, gum arabic, chitosan, cyclodextrin, and gelatin.

9. The blood sugar regulating health care composition according to claim 8, characterized in that, The cinnamon component further comprises the cinnamon powder obtained through step a.

10. The blood sugar regulating health care composition according to claim 1, characterized in that, It also contains at least one of sweeteners, carriers, antioxidants, and combinations thereof.

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