A pharmaceutical composition for treating chronic glomerulonephritis, its preparation method and application

Through the ethanol extraction and water extraction process of traditional Chinese medicine compositions, a pharmaceutical composition for the treatment of chronic glomerulonephritis was prepared, which solved the adverse reactions and risks of existing treatment methods and achieved efficient and safe therapeutic effects.

CN117695362BActive Publication Date: 2025-07-25THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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Patent Information

Application Number
CN202311823094.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-12-27
Publication Date
2025-07-25
Estimated Expiration
2043-12-27

AI Technical Summary

Technical Problem

The existing treatment methods for chronic glomerulonephritis have adverse reactions and increased stroke risk, and the application of traditional Chinese medicine in this field has not yet fully realized its potential.

Method used

Traditional Chinese medicine compositions such as white soil yam, big belly velvet, ephedra, Yunfangfeng, yam, horseshoe gold, Yancodon, Diandan miltiorrhiza, earth acne saphenoushis, etc. are used to extract the active ingredients through ethanol extraction and water extraction methods to make pharmaceutically acceptable preparations and use them in combination with Western medicine.

Benefits of technology

It significantly improved the treatment effect of chronic glomerulonephritis, with a total effective efficiency of 84%, significantly reduced urinary protein and urinary erythrocytes, and had no adverse reactions, and was highly safe.

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Abstract

The present invention relates to a pharmaceutical composition for treating chronic glomerulonephritis, its preparation method and application. The pharmaceutical composition is composed of Rhizoma Smilacis Glabrae Albae, Flos Abelmoschi Manihot, Herba Ephedrae Delavayi, Radix Saposhnikoviae Divaricatae, Ramulus Ulmi Pumilae, Herba Dichondrae Repentis, Rhizoma Corydalis Saxicolae, Radix Salviae Yunnanensis, and Radix Achyranthis Aspera. The preparation method is to first extract the above nine herbs with ethanol and then with water, and the mixed solution is concentrated to make a pharmaceutical preparation. The combined use of this pharmaceutical preparation and western medicine can improve the treatment effect of chronic glomerulonephritis, with a total effective rate reaching 84%. Moreover, it can significantly reduce the urinary protein and red blood cells in patients, showing a significant difference compared with the control group using western medicine alone. This indicates that it can effectively improve the clinical symptoms of patients, has no adverse reactions, has high safety, and has extremely high popularization value.
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