Preparation method of Chinese herbal medicine abelmoschus manihot foot bath bag composition

Abstract

The invention discloses a preparation method of a Chinese herbal medicine abelmoschus manihot foot bath bag composition, and relates to the technical field of traditional Chinese medicine external preparations. Comprising the following steps: (1) raw material compatibility and pretreatment: taking 10-30 parts by mass of abelmoschus manihot stems, 10-25 parts by mass of abelmoschus manihot flowers, 8-20 parts by mass of lysimachia christinae hance, 5-15 parts by mass of rheum officinale, 5-15 parts by mass of cortex dictamni, 5-15 parts by mass of cocklebur fruits, 5-15 parts by mass of duckweed, 5-15 parts by mass of folium artemisiae argyi, 5-15 parts by mass of senecio scandens, 3-10 parts by mass of nidus vespae, 3-10 parts by mass of zaocys dhumnade, 3-10 parts by mass of stiff silkworms, 3-10 parts by mass of earthworms, 5-15 parts by mass of The traditional Chinese medicine composition has the following remarkable advantages that the abelmoschus manihot stems and the abelmoschus manihot flowers are used as monarch drugs, so that the effects of clearing heat, promoting diuresis, promoting blood circulation and dredging collaterals are achieved; animal medicinal materials such as zaocys dhumnade, bombyx batryticatus and lumbricus are matched, so that the effects of Various medicinal materials have a synergistic effect, so that the dual effects of treatment and health care are realized; segmented irradiation sterilization is adopted, so that the effective component loss is reduced while the sterilization effect is ensured.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of external preparation of traditional Chinese medicine, in particular to a preparation method of a Chinese herbal medicine malva sylvestris foot bath bag composition. BACKGROUND

[0002] As a traditional external treatment method of traditional Chinese medicine, the foot bath can achieve the purpose of preventing and treating diseases through drug absorption through the skin and meridian conduction. Modern research shows that the foot has the reflection area of each organ of the human body, and the corresponding organ function can be adjusted through bath stimulation. The foot bath products on the market have the following problems: simple formula, mainly single effect, lack of comprehensive conditioning effect; uneven quality of medicinal materials, unstable content of effective components; rough preparation process, incomplete sterilization, risk of microbial contamination; improper handling of animal medicinal materials, serious loss of effective components; poor sealing of packaging materials, easy to be damp and deteriorate; lack of systematic efficacy verification and safety evaluation.

[0003] The existing foot bath products mostly adopt the process of directly packaging after simple crushing, fail to fully exert the synergistic effect of medicinal materials, and have obvious deficiencies in the handling of animal medicinal materials, therefore, developing a Chinese medicine foot bath bag with scientific formula, advanced process and stable quality has important market value and clinical significance. SUMMARY

[0004] In view of the deficiencies of the prior art, the application provides a preparation method of a Chinese herbal medicine malva sylvestris foot bath bag composition, which solves the technical problems that the existing foot bath products mostly adopt the process of directly packaging after simple crushing, fail to fully exert the synergistic effect of medicinal materials, and have obvious deficiencies in the handling of animal medicinal materials.

[0005] To achieve the above object, the application is implemented by the following technical scheme: a preparation method of a Chinese herbal medicine malva sylvestris foot bath bag composition, comprising the following steps: (1) raw material compounding and pretreatment: taking malva sylvestris stem and branch 10-30 parts, malva sylvestris flower 10-25 parts, herba lycopus 8-20 parts, radix et rhizoma rhei 5-15 parts, cortex periplocae 5-15 parts, semen crotonis 5-15 parts, lemnaceae 5-15 parts, folium artemisiae argyi 5-15 parts, herba senecionis 5-15 parts, herba erioglossi 3-10 parts, ophiophagus hannah 3-10 parts, bombyx batryticatus 3-10 parts, herba lumbrici 3-10 parts, rhizoma coptidis 5-15 parts, flos chrysanthemi indici 5-15 parts, cortex phellodendri 5-15 parts, herba typhoides 5-15 parts, fructus gleditsiae 5-15 parts, borneolum syntheticum 1-5 parts, camphor crystal 1-5 parts according to mass fraction; washing the plant medicinal materials and drying at 45-60 DEG C under low temperature until the water content is lower than 8%; (2) raw material sterilization treatment: sterilizing the dried medicinal materials by Co-60 irradiation, and the irradiation dose is 6-10 kGy; (3) Ultrafine grinding: Mix the sterilized medicinal materials and grind them to a particle size of 40-80 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Processing of animal medicinal materials: The black-tailed snake, silkworm and earthworm were pulverized to 60-100 mesh using low-temperature freeze pulverization technology; (5) Raw material mixing: Mix the plant medicinal powder and animal medicinal powder according to the ratio, add borneol and camphor crystals, and mix for 30-60 minutes using a three-dimensional motion mixer; (6) Pretreatment of packaging materials: Medical-grade non-woven fabric is used as packaging material and is disinfected with ultraviolet light in advance; (7) Quantitative packaging: The evenly mixed powder is packaged into non-woven bags in three specifications of 10g, 15g and 20g, and then heat-sealed using an automatic packaging machine; (8) Finished product packaging: Pack the foot bath packs into a box with 30 packs / box and then perform final sterilization by irradiation.

[0006] Preferably, the mass fractions of the raw materials mentioned in step (1) are as follows: 15-25 parts of okra stems, 15-20 parts of golden sunflower flowers, 10-15 parts of Lysimachia christinae, 8-12 parts of rhubarb, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Xanthium sibiricum, 8-12 parts of duckweed, 8-12 parts of Artemisia argyi, 8-12 parts of Senecio scandens, 5-8 parts of wasp nest, 5-8 parts of black-spotted snake, 5-8 parts of silkworm pupae, 5-8 parts of earthworm, 8-12 parts of Coptis chinensis, 8-12 parts of wild chrysanthemum, 8-12 parts of Phellodendron chinense, 8-12 parts of Acorus calamus, 8-12 parts of Gleditsia sinensis, 2-4 parts of borneol, and 2-4 parts of camphor crystals.

[0007] Preferably, the irradiation sterilization in step (2) is carried out by segmented irradiation: first, irradiate with a dose of 4-5 kGy, let stand for 24 hours, and then supplement with a dose of 2-3 kGy.

[0008] Preferably, the ultrafine pulverization in step (3) adopts airflow pulverization technology, and the temperature is controlled not to exceed 40°C during the pulverization process.

[0009] Preferably, the temperature of the cryogenic pulverization in step (4) is -30°C to -50°C, and the pulverization process is carried out under inert gas protection.

[0010] Preferably, in step (5), a plant essential oil synergist accounting for 1%-3% of the total mass of the medicinal materials is added, wherein the synergist is a mixture of tea tree essential oil, eucalyptus essential oil or peppermint essential oil.

[0011] Preferably, the nonwoven fabric mentioned in step (6) is a biodegradable plant fiber nonwoven fabric with a basis weight of 30-50 g / m². 2 Breathability not less than 500L / m 2 ·s.

[0012] Preferably, the heat sealing temperature in step (7) is 150-180℃, the pressure is 0.3-0.5MPa, and the pressure holding time is 2-4 seconds.

[0013] Beneficial effects This invention provides a method for preparing a herbal foot bath pack composition of *Hippophae rhamnoides* (golden hibiscus). This invention has the following significant advantages: It uses the stems and flowers of *Hippophae rhamnoides* as the principal ingredients, clearing heat and dampness, promoting blood circulation and unblocking collaterals; it is combined with animal-derived medicinal materials such as *Zaocys dhumnades*, *Bombyx mori*, and *Pheretima aspergillum* to enhance the effect of dispelling wind and unblocking collaterals; the synergistic effect of multiple medicinal materials achieves both therapeutic and health-preserving effects; segmented irradiation sterilization ensures sterilization effectiveness while minimizing the loss of active ingredients; low-temperature freeze-drying technology maximizes the preservation of the bioactivity of the animal-derived medicinal materials; three-dimensional mixing ensures uniform distribution of the medicinal materials; it is safe, environmentally friendly, and biodegradable: all natural medicinal materials are used, with no toxic side effects; the packaging material is biodegradable and environmentally friendly; multiple sterilization processes ensure that microbial indicators meet requirements; it is convenient to use and has significant effects: multiple specifications are provided to meet different needs; detailed usage instructions ensure correct use; and experimental results have proven that it has a significant improving effect on various foot problems. Detailed Implementation

[0014] The present invention will be further described in detail below through specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.

[0015] Example 1: A method for preparing a foot bath pack composition of the traditional Chinese medicine *Hypericum perforatum*, comprising the following steps: Raw material compatibility and pretreatment: Take 20 parts by weight of the stems and stalks of Abelmoschus manihot, 18 parts of the flowers of Abelmoschus manihot, 12 parts of Lysimachia christinae, 10 parts of rhubarb, 10 parts of Dictamnus dasycarpus, 10 parts of Xanthium sibiricum, 10 parts of duckweed, 10 parts of Artemisia argyi, 10 parts of Senecio scandens, 6 parts of Vespa nidus, 6 parts of Zaocys dhumnades, 6 parts of Bombyx mori, 6 parts of Pheretima aspergillum, 10 parts of Coptis chinensis, 10 parts of Chrysanthemum indicum, 10 parts of Phellodendron chinense, 10 parts of Acorus calamus, 10 parts of Gleditsia sinensis, 3 parts of borneol, and 3 parts of camphor crystals. After washing, the medicinal materials are dried at 50℃ until the moisture content is 7.5%. (2) Sterilization of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation. The irradiation sterilization is carried out in stages: first, irradiate with a dose of 4.5 kGy, let stand for 24 hours, and then supplement the irradiation with a dose of 2.5 kGy. (3) Ultrafine grinding: The sterilized medicinal materials are mixed and then ground at a temperature below 35°C to a particle size of 60 mesh to obtain uniform powder of medicinal materials; (4) Processing of animal medicinal materials: The black-tailed snake, silkworm and earthworm were frozen and pulverized to 80 mesh at -40℃ using low temperature freeze pulverization technology; (5) Raw material mixing: Mix the plant medicine powder and animal medicine powder according to the ratio, add borneol and camphor crystals, mix for 45 minutes using a three-dimensional motion mixer, and add 2% plant essential oil synergist; (6) Pretreatment of packaging materials: using 45g / m 2 Plant fiber nonwoven fabric is used as packaging material and is pre-sterilized with ultraviolet light. (7) Quantitative packaging: The mixed powder is packaged in non-woven bags in 15g / bag specifications, and then heat-sealed using an automatic packaging machine at a heat-sealing temperature of 165℃, a pressure of 0.4MPa, and a pressure holding time of 3 seconds. (8) Finished product packaging: Pack the foot bath packs into a box with 30 packs / box and then perform final sterilization by irradiation.

[0016] Example 2: A method for preparing a herbal foot bath pack composition of *Hypericum perforatum*, comprising the following steps: Raw material compatibility and pretreatment: Take 25 parts by weight of okra stems, 15 parts of golden sunflower flowers, 15 parts of Lysimachia christinae, 8 parts of rhubarb, 12 parts of Dictamnus dasycarpus root bark, 8 parts of Xanthium sibiricum, 12 parts of duckweed, 8 parts of Artemisia argyi, 12 parts of Senecio scandens, 5 parts of bee honeycomb, 8 parts of Zaocys dhumnades, 5 parts of Bombyx mori, 8 parts of Pheretima aspergillum, 8 parts of Coptis chinensis, 12 parts of Chrysanthemum indicum, 8 parts of Phellodendron chinense, 12 parts of Acorus calamus, 8 parts of Gleditsia sinensis, 2 parts of borneol, and 4 parts of camphor crystals. After washing, the medicinal materials are dried at 60℃ until the moisture content is 8%. (2) Sterilization of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation. The irradiation sterilization is carried out in stages: first, irradiate with a dose of 4 kGy, let stand for 24 hours, and then supplement the irradiation with a dose of 3 kGy. (3) Ultrafine grinding: Mix the sterilized medicinal materials and grind them using ultrafine grinding technology. Plant medicinal materials are ground to 50 mesh, and animal medicinal materials are ground to 70 mesh at -35℃. (4) Processing of animal medicinal materials: The black-tailed snake, silkworm and earthworm were frozen and pulverized to 80 mesh at -50℃ using low temperature freeze pulverization technology; (5) Raw material mixing: Mix the plant medicinal powder and animal medicinal powder according to the ratio, add borneol and camphor crystals, mix for 60 minutes using a three-dimensional motion mixer, and add 1.5% plant essential oil synergist; (6) Pretreatment of packaging materials: using 45g / m 2 Plant fiber nonwoven fabric is used as packaging material and is pre-sterilized with ultraviolet light. (7) Quantitative packaging: The mixed powder is packaged in non-woven bags in 20g / bag specifications, and then heat-sealed using an automatic packaging machine at a heat-sealing temperature of 170℃, a pressure of 0.4MPa, and a pressure holding time of 3 seconds. (8) Finished product packaging: Pack the foot bath packs into a box with 30 packs / box and then perform final sterilization by irradiation.

[0017] Comparative Example 1 Traditional preparation method: According to the formula in Example 1, the medicinal materials are pulverized to 20 mesh at room temperature, without irradiation sterilization, and then simply mixed and packaged.

[0018] Comparative Example 2 Commercially available foot bath packs: a certain brand of traditional Chinese medicine foot bath packs.

[0019] Physicochemical index testing Stability test Accelerated testing for 3 months at 40°C and 75% relative humidity: Example 1: No change in appearance, effective ingredient retention rate 95.2%; Comparative Example 1: Clumping occurred, effective ingredient retention rate 72.3%; Comparative Example 2: Slight discoloration, effective ingredient retention rate 83.6%.

[0020] Efficacy Evaluation 120 patients with tinea pedis were randomly divided into three groups: Example 1 group: using the foot bath pack of the present invention once a day; Comparative Example 1 group: using the traditional foot bath pack once a day; Comparative Example 2 group: using commercially available foot bath packs once a day. Observe the efficacy after 4 weeks of treatment: Safety assessment The incidence of adverse reactions in Group 1 of Example 1 was 2.5%, mainly manifested as mild skin dryness; The incidence of adverse reactions in the comparative group 1 was 12.5%, including skin irritation and increased itching; The incidence of adverse reactions in the comparative group 2 was 7.5%.

[0021] Consumer experience survey The survey covered aspects such as ease of use, pleasant smell, and satisfaction with the effect: 96% satisfaction rate in Example 1 group; 75% satisfaction rate in Comparative Example 1 group; and 82% satisfaction rate in Comparative Example 2 group.

[0022] Other efficacy observations Improvements in sleep aid and fatigue relief: This invention, through scientific raw material formulation and advanced preparation technology, has successfully developed a comprehensive and safe herbal foot bath pack containing *Golden Flower Sunflower*. Compared with traditional methods, this product has significant advantages in terms of quality stability, efficacy, and safety, especially showing better therapeutic effects on foot problems such as athlete's foot. It also has good health benefits, providing consumers with a high-quality herbal foot bath product.

[0023] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

Claims

1. A method for preparing a foot bath pack composition of the traditional Chinese medicine *Hypericum perforatum*, characterized in that, Includes the following steps: (1) Raw material compatibility and pretreatment: Take 10-30 parts by weight of the stems and stalks of the yellow hibiscus, 10-25 parts of the flowers of the golden sunflower, 8-20 parts of the lysimachia christinae, 5-15 parts of rhubarb, 5-15 parts of the white peony bark, 5-15 parts of cocklebur, 5-15 parts of duckweed, 5-15 parts of mugwort, 5-15 parts of senecio scandens, 3-10 parts of bee honeycomb, 3-10 parts of black-spotted snake, 3-10 parts of silkworm, 3-10 parts of earthworm, 5-15 parts of coptis chinensis, 5-15 parts of wild chrysanthemum, 5-15 parts of phellodendron bark, 5-15 parts of calamus, 5-15 parts of soapberry, 1-5 parts of borneol, and 1-5 parts of camphor crystals. After washing, the medicinal plants are dried at a low temperature of 45-60℃ until the moisture content is below 8%. (2) Sterilization of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation with an irradiation dose of 6-10 kGy; (3) Ultrafine grinding: Mix the sterilized medicinal materials and grind them to a particle size of 40-80 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Processing of animal medicinal materials: The black-tailed snake, silkworm and earthworm were pulverized to 60-100 mesh using low-temperature freeze pulverization technology; (5) Raw material mixing: Mix the plant medicinal powder and animal medicinal powder according to the ratio, add borneol and camphor crystals, and mix for 30-60 minutes using a three-dimensional motion mixer; (6) Pretreatment of packaging materials: Medical-grade non-woven fabric is used as packaging material and is disinfected with ultraviolet light in advance; (7) Quantitative packaging: The evenly mixed powder is packaged into non-woven bags in three specifications of 10g, 15g and 20g, and then heat-sealed using an automatic packaging machine; (8) Finished product packaging: Pack the foot bath packs into a box with 30 packs / box and then perform final sterilization by irradiation.

2. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The mass fractions of the raw materials mentioned in step (1) are as follows: 15-25 parts of okra stems, 15-20 parts of sunflower flowers, 10-15 parts of Lysimachia christinae, 8-12 parts of rhubarb, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Xanthium sibiricum, 8-12 parts of duckweed, 8-12 parts of Artemisia argyi, 8-12 parts of Senecio scandens, 5-8 parts of wasp nest, 5-8 parts of Zaocys dhumnades, 5-8 parts of Bombyx mori, 5-8 parts of earthworm, 8-12 parts of Coptis chinensis, 8-12 parts of Chrysanthemum indicum, 8-12 parts of Phellodendron chinense, 8-12 parts of Acorus calamus, 8-12 parts of Gleditsia sinensis, 2-4 parts of borneol, and 2-4 parts of camphor crystals.

3. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The irradiation sterilization described in step (2) adopts segmented irradiation: first, irradiate with a dose of 4-5 kGy, let stand for 24 hours, and then supplement with a dose of 2-3 kGy.

4. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The ultrafine grinding in step (3) adopts airflow grinding technology, and the temperature is controlled not to exceed 40℃ during the grinding process.

5. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The temperature of the cryogenic pulverization in step (4) is -30℃ to -50℃, and the pulverization process is carried out under the protection of inert gas.

6. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Hypericum perforatum* according to claim 1, characterized in that, In step (5), a plant essential oil enhancer accounting for 1%-3% of the total mass of the medicinal materials is also added. The enhancer is a mixture of tea tree oil, eucalyptus oil or peppermint oil.

7. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The nonwoven fabric mentioned in step (6) is a biodegradable plant fiber nonwoven fabric with a basis weight of 30-50 g / m². 2 Breathability not less than 500L / m 2 ·s.

8. The method for preparing a foot bath pack composition of the traditional Chinese medicine *Gynostemma pentaphyllum* according to claim 1, characterized in that, The heat sealing temperature in step (7) is 150-180℃, the pressure is 0.3-0.5MPa, and the pressure holding time is 2-4 seconds.

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