Miniature integrated production line for traditional Chinese medicine temporary prescription preparation and production method thereof

Abstract

The invention discloses a traditional Chinese medicine temporary prescription preparation miniature integrated production line and a production method thereof. The decoction concentration module is used for decocting decoction, and the decoction is conveyed to the micro concentration device through a first vacuum conveying pipe to generate a concentrated solution; the input end of the drying and granulating module is connected with the output end of the micro concentration device through a second vacuum conveying pipe, and the drying and granulating module is used for receiving the concentrated solution and preparing granules; the forming module is used for pressing and forming the granules; and the control system is used for pre-storing process parameter libraries of different medicinal materials, is in communication connection with each module and the transfer pipeline, and regulates and controls the actions and various parameters of each module and the pump body in real time. The AI intelligent control-based intelligent miniaturized highly-integrated production line which integrates decoction, concentration and extraction, spray drying and tabletting of decoction pieces and is specially customized for individualized preparation mixtures is provided, the processing capacities of all the modules are matched, and highly-automatic continuous production from decoction pieces to temporary mixtures, granules or tablets can be completed within 2 hours.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine processing and production, and in particular to a micro integrated production line for traditional Chinese medicine prescriptions and a production method thereof. BACKGROUND

[0002] The treatment feature of traditional Chinese medicine is personalized treatment, that is, "one prescription for one person". In the traditional way, the patient needs to decoct the traditional Chinese medicine by himself / herself. However, with the development of the times, due to the disadvantages of inconvenience in carrying and difficulty in storage, the development of traditional Chinese medicine is restricted to some extent.

[0003] At present, there are methods for converting traditional Chinese medicine into different forms such as decoction, pills and granules in the market, which are convenient for patients to use and drink immediately. However, the traditional Chinese medicine made into finished products is basically the commonly used and directly marketable prescription, and the traditional equipment on the market is basically independently produced in single prescription, large dose and single process.

[0004] Due to the limitation of "one prescription for one person", the quantity of hospital prescription decoction pieces is small, the types are many, and the conversion from decoction pieces to prescription preparations needs to be completed within 2 hours. In the existing equipment, the concentration, granulation and packaging equipment are independently separated, which leads to large occupation of production line and high energy consumption, and it is difficult to meet the demand of "2-hour rapid response" of hospital prescription. In addition, the single drug has strong targeting, and the requirement for the effect of finished product is more strict. SUMMARY

[0005] The technical problem solved by the present application is how to realize the personalized customization of traditional Chinese medicine, improve the production efficiency and ensure the effect of the drug.

[0006] According to a first aspect, a micro integrated production line for traditional Chinese medicine prescriptions is provided in an embodiment, comprising:

[0007] an integrated platform;

[0008] a decoction and concentration module, comprising a micro decoction device and a micro concentration device, the micro decoction device is used for decocting traditional Chinese medicine to form a decoction, and the micro concentration device is used for concentrating the decoction to form a concentrated liquid; the input end of the micro concentration device is communicated with the output end of the micro decoction device through a first vacuum conveying pipe, and the first vacuum conveying pipe maintains negative pressure to transfer the concentrated liquid;

[0009] a drying and granulation module, the input end of which is connected to the output end of the micro concentration device through a second vacuum conveying pipe, and is used for receiving the concentrated liquid and making granules;

[0010] a forming module, the input end of which is connected to the output end of the drying and granulation module, and is used for pressing and forming the granules; and

[0011] The control system has a pre-stored database of process parameters for different medicinal materials. It is communicatively connected to the decoction and concentration module, the drying and granulation module, the forming module, the first vacuum conveying pipe, and the second vacuum conveying pipe, and controls the actions and parameters in real time during the decoction, concentration, drying, tableting, and conveying processes.

[0012] In another embodiment, a process concentration detection module is also included, which is disposed between the decoction and concentration module and the drying and granulation module. The process concentration detection module is communicatively connected to the control system and is used to detect the drug concentration of the concentrate and to separate qualified concentrate and substandard concentrate.

[0013] In another embodiment, the process concentration detection module includes a detection pipe, a qualified pipe, a defective pipe, and a diversion switch. One end of the detection pipe is connected to the output end of the micro-concentrator, and the other end is connected to the qualified pipe and the defective pipe through the diversion switch. The detection pipe is equipped with a detection element for detecting liquid concentration. The detection element and the diversion switch are controlled by the control system to switch the pipes to divert qualified concentrate and defective concentrate.

[0014] In another embodiment, the process concentration detection module further includes a cleaning pipe and a cleaning switch. One end of the cleaning pipe is connected to a water source, and the other end is connected to the output end of the cleaning switch and the micro-concentrator. The cleaning switch is controlled by the control system to switch the pipe for cleaning.

[0015] In another embodiment, the micro-concentrating device is equipped with a compound preparation packaging device. The input end of the compound preparation packaging device is connected to the output end of the micro-concentrating device through a third vacuum delivery tube and is used to package a quantitative compound preparation medicine.

[0016] In another embodiment, the drying and granulation module is a micro spray dryer granulator, which converts the concentrate into granules through a spray drying process, and the processing capacity of the spray dryer granulator is matched and configured to correspond with the micro concentration device.

[0017] In another embodiment, the forming module includes a micro tableting device, the input of which is connected to the output of the drying and granulation module via a fourth vacuum delivery pipe, using negative pressure to transfer the granules and perform tableting.

[0018] In another embodiment, a solid packaging module is also provided at the output end of the molding module, the solid packaging module being used to seal and package the fixed molding agent.

[0019] According to the second aspect, one embodiment provides a method for producing a traditional Chinese medicine preparation conversion device, employing the aforementioned micro-integrated production line for intra-operative traditional Chinese medicine preparations, comprising the following steps:

[0020] Decoction: The medicinal slices are put into a micro decoction device for decoction to produce a soup.

[0021] Concentration: The decoction is transferred through a first vacuum delivery tube to a micro-concentration device to generate a concentrated liquid;

[0022] Spray drying granulation: The concentrated liquid enters the drying granulation module through the second vacuum conveying pipe to produce granules;

[0023] Pharmaceutical forming: Granules are conveyed by vacuum or mechanically transferred to the forming module and pressed into the desired shape or directly enter the packaging process.

[0024] The entire process is controlled, and the control system adjusts the actions and parameters in real time during the decoction, concentration, drying, shaping and transportation processes to complete the conversion of medicinal slices into compound preparations, granules or tablets.

[0025] In another embodiment, after the decoction is concentrated to form a concentrated liquid, the concentration is detected. The control system presets a concentration threshold range. Based on the comparison between the detection data and the preset concentration threshold range, the control system separates the qualified concentrated liquid from the substandard concentrated liquid.

[0026] According to the above-described embodiment, the micro-integrated production line and method for TCM prescription preparations utilize a micro-decoction device, a micro-concentration device, a drying and granulation module, and a negative pressure pipeline conveying system running throughout the entire line. This ensures zero contact and no residue transfer of materials between modules. The integrated control system dynamically retrieves process parameter databases and controls in real-time parameters such as decoction temperature, concentration vacuum, spray drying inlet air temperature, and tableting pressure. This achieves fully automated continuous production from the input of medicinal materials to the output of compound / granule / tablet preparations. Ultimately, this significantly improves the production cycle of TCM prescription preparations, meeting the production needs of hospital pharmacies for small-batch, multi-batch, and urgent prescription preparations. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the overall integrated production line for micro-integrated traditional Chinese medicine prescriptions.

[0028] Figure 2 This is a schematic diagram of the internal production line of the integrated platform in one embodiment;

[0029] Figure 3 This is a schematic diagram of the overall micro-integrated production line in one embodiment;

[0030] Figure 4 This is a schematic diagram of the overall structure of the decoction and concentration module in one embodiment;

[0031] Figure 5 This is a schematic diagram of the overall structure of the process concentration detection module in one embodiment;

[0032] Figure 6 This is a schematic diagram of the control system of a micro-integrated production line for traditional Chinese medicine prescriptions in one embodiment;

[0033] Figure 7 This is a schematic diagram of the production process of a micro-integrated production line for traditional Chinese medicine prescriptions in one embodiment.

[0034] Figure label:

[0035] 1. Integration platform;

[0036] 2. Decoction and concentration module; 21. Micro decoction device; 22. First vacuum conveying pipe; 23. Micro concentration device; 231. Spherical concentration tank; 232. Gas-liquid separator; 233. Condenser; 234. Liquid receiving tank; 235. Condensation circulation pump; 236. Circulation supply tank; 24. Second vacuum conveying pipe; 25. Feeding pump;

[0037] 3. Process concentration detection module; 31. Detection pipeline; 32. Qualified pipeline; 33. Defective pipeline; 34. Diverter switch; 35. Cleaning pipeline; 36. Switch valve; 37. Cleaning switch; 38. Detection component;

[0038] 4. Mixture packaging device; 41. Third vacuum conveying pipe;

[0039] 5. Drying and granulation module; 51. Fourth vacuum conveying pipe; 52. Drying tower; 53. Hot air system; 54. Cyclone separator;

[0040] 6. Molding module;

[0041] 7. Solid packaging module;

[0042] 8. Control system. Detailed Implementation

[0043] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings. Similar elements in different embodiments are referred to by associated similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of this application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to this application are not shown or described in the specification. This is to avoid obscuring the core parts of this application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0044] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0045] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include both direct and indirect connections (linkages).

[0046] Currently, there are methods available on the market to convert traditional Chinese medicine (TCM) into different forms, such as decoctions, pills, and granules, for patients to use immediately. However, the finished TCM products are mostly commonly used and readily marketable prescriptions. Furthermore, current traditional equipment is primarily designed for single-prescription, large-dose, and single-process independent production. Due to the "one prescription per person" limitation, hospital prescriptions require small quantities and diverse types of medicinal herbs, and the conversion from herbs to prescription formulations needs to be completed within 2 hours. Existing equipment separates concentration, granulation, and packaging processes, resulting in large production lines, high energy consumption, and difficulty in meeting the "2-hour rapid response" requirement for hospital prescriptions. Moreover, individual medications are highly targeted, demanding stricter efficacy standards for the finished products.

[0047] This application provides a fully enclosed, miniaturized, and intelligently controlled integrated production line that enables rapid conversion from medicinal slices to compound preparations / granules / tablets within 2 hours, solving the efficiency, quality, and compatibility issues in small-batch production of prescription preparations.

[0048] On the one hand, please refer to Figure 1 , Figure 2 and Figure 3One embodiment provides a micro-integrated production line for traditional Chinese medicine (TCM) prescription preparations, comprising: an integrated platform 1; a decoction and concentration module 2, including a micro-decoction device 21 and a micro-concentration device 23, wherein the micro-decoction device 21 is used to decoct TCM to form a decoction, and the micro-concentration device 23 is used to concentrate the decoction to form a concentrated liquid; the input end of the micro-concentration device 23 is connected to the output end of the micro-decoction device 21 through a first vacuum conveying pipe 22, and a negative pressure is maintained in the first vacuum conveying pipe 22 to transfer the concentrated liquid; a drying and granulation module 5, the input end of which is connected to the output end of the micro-concentration device 23 through a second vacuum conveying pipe 24, and is used to receive the concentrated liquid and make granules; a forming module 6, the input end of which is connected to the output end of the drying and granulation module 5, and is used to press the granules into shapes; and a control system 8, which pre-stores a database of process parameters for different medicinal materials, and is communicatively connected to the decoction and concentration module 2, the drying and granulation module 5, the forming module 6, and the first vacuum conveying pipe 22 and the second vacuum conveying pipe 24, and controls the actions and parameters in the decoction, concentration, drying, tableting and conveying processes in real time.

[0049] The micro-integrated production line for temporary Chinese medicine preparations disclosed in this application, through the matching and configuration of the processing capacities of the micro-decoction device 21, the micro-concentration device 23, and the drying and granulation module 5, combined with the negative pressure pipeline conveying system running through the entire line, enables zero contact and residue-free transfer of materials between modules. The integrated platform 1 integrates functions such as construction, concentration, granulation, packaging, and conveying. The integrated control system 8 dynamically retrieves process parameter libraries and adjusts the decoction temperature, concentration vacuum degree, spray drying inlet air temperature, and tableting pressure parameters in real time, realizing fully automated continuous production from the input of medicinal materials to the output of compound / granule / tablet preparations. This greatly improves the production cycle of temporary Chinese medicine preparations, meeting the production needs of hospital pharmacies for small-batch, multi-batch, and urgent temporary preparations.

[0050] Furthermore, in one embodiment, please refer to Figure 3 and Figure 4 The micro decoction device 21 is a multi-functional automatic decoction machine, including a fixed-volume tank, an internal ultrasonic anti-sticking array and a porous filter basket, and a bottom electric heating plate. It supports switching between wrapped decoction and loose decoction modes. The tank can be a 5L stainless steel tank. The tank has an outlet near the bottom where a first vacuum delivery pipe 22 is installed. The other end of the first vacuum delivery pipe 22 is connected to the input end of the micro concentration device 23. The decoction tank has a built-in pressure sensor and an ultrasonic level gauge. The control system 8 dynamically adjusts the decoction water volume according to the type of medicinal material.

[0051] Compared to traditional decoction pots, the sealed container, due to the pressure, makes it easier to extract the active ingredients from Chinese medicinal herbs, and facilitates the hydrolysis of proteins in animal-derived medicines. By applying pressure and high temperature, the extraction rate of active ingredients is increased, solving the problem of "pre-decoction" in traditional Chinese medicine. Simultaneously, the sealed decoction process allows aromatic drugs to be fully preserved, solving the problem of "added later" in traditional Chinese medicine. The entire decoction process is automated, with the control system 8 controlling temperature, pressure, and time, resulting in more stable medicinal efficacy.

[0052] In other embodiments, the wall of the first vacuum delivery tube 22 is fitted with an insulation layer to maintain the temperature of the pharmaceutical agent.

[0053] For further details, please refer to... Figure 3 and Figure 4 The spherical concentration device mainly includes a spherical concentration tank 231, a gas-liquid separator 232, a condenser 233, and a receiving tank 234. The spherical concentration tank 231 is a jacketed type, with a steam inlet on the jacket. The steam inlet is connected to a steam pipe, which is connected to a steam channel via a flange. A liquid outlet is located at the bottom of the jacket. The top of the upper shell of the spherical concentration tank 231 has a feed port for connecting to the first vacuum delivery pipe 22. A vacuum pump is installed at the upper end of the spherical concentration tank 231 to evacuate the tank and lower the boiling point of the reagent. A thermometer and a pressure gauge are also installed at the upper end of the spherical concentration tank 231.

[0054] Please refer to Figure 3 and Figure 4 A steam pipe is led out from the side of the gas-liquid separator 232 and connected to the upper end of the spherical concentration tank 231. A condenser pipe is led out from the upper end of the gas-liquid separator 232 and connected to the cooler. A return pipe connected to the spherical concentration tank 231 is also provided at the lower end of the gas-liquid separator 232.

[0055] Please refer to Figure 3 and Figure 4 The bottom end of the condenser 233 is fixedly connected to the top of the liquid receiving tank 234. The condenser 233 is provided with upper and lower circulation pipes of different heights. The upper circulation pipe is used to connect to the upper end of a circulation supply tank 236. The lower circulation pipe is equipped with a condensation circulation pump 235 and is used to connect close to the bottom wall of the circulation supply tank 236. The lower end of the liquid receiving tank 234 is provided with a discharge port and connected to a second vacuum conveying pipe 24. A feed pump 25 is installed on the second vacuum conveying pipe 24 to send the concentrate to the next process.

[0056] In this embodiment, the spherical concentrator of the micro-concentrator 23 is matched to the tank of the micro-decoction device 21 in a 1:1 capacity ratio. This matching capacity improves production efficiency, allowing for the processing of the pharmaceutical agent in a single step. The spherical concentrator, employing reduced pressure vacuum and low-temperature concentration, achieves a shorter concentration time while preserving the effective components of heat-sensitive materials. Furthermore, all parts of the micro-concentrator 23 that come into contact with the material are made of stainless steel, exhibiting excellent corrosion resistance, durability, and compliance with GMP requirements.

[0057] In other embodiments, the spherical concentration tank 231 may be equipped with a stirring and cleaning device that contacts the inner wall to prevent the drug from sticking to the wall and settling to the bottom.

[0058] Please refer to Figure 5 The micro-concentrator 23 is equipped with a process concentration detection module 3, which is specifically used to detect the concentration of the liquid concentrate to ensure efficacy. The process concentration detection module 3 is connected to the control system 8, and the control system 8 separates qualified concentrate and substandard concentrate according to the detection data.

[0059] For details, please refer to Figure 5 The process concentration detection module 3 includes a detection pipe 31, a qualified pipe 32, a defective pipe 33, a diversion switch 34, a cleaning pipe 35, and a cleaning switch 37. In this embodiment, the process concentration detection module 3 is positioned in the middle of the second vacuum delivery pipe 24. One end of the detection pipe 31 is connected to the output end of the micro-concentrator 23. One end of the cleaning pipe 35 is connected to a water source, and the other end is connected to the cleaning switch 37 and the output end of the micro-concentrator 23 through the cleaning switch 37. The cleaning switch 37 is controlled by the control system 8 to switch the pipes to clean the pipe 35. The other end of the detection pipe 31 is connected to the qualified pipe 32 and the defective pipe 33 through the diversion switch 34. A detection element 38 for detecting liquid concentration is installed on the detection pipe 31. The detection element 38 and the diversion switch 34 are controlled by the control system 8 to switch the pipes to divert qualified concentrate and defective concentrate.

[0060] Please refer to Figure 5 Both the diversion switch 34 and the cleaning switch 37 adopt a two-position three-way solenoid valve. The cleaning switch 37 includes a drug inlet, a drug outlet and a cleaning inlet. The drug inlet is used to connect to the second vacuum delivery pipe 24, the drug outlet is used to connect to the detection pipe 31, and the cleaning inlet is used to connect to the cleaning pipe 35. The cleaning pipe 35 is used to connect to the cleaning water source.

[0061] Further reference Figure 5A switch valve 36 is installed on the cleaning pipe 35. In this embodiment, the switch valve 36 can be a manual valve or a solenoid valve. It can be manually opened after a batch of medicine is converted, or the control system 8 can control the switch, allowing high-pressure water to enter the pipe for cleaning. The detection program of the control system 8 is temporarily inactive. The cleaning pipe 35 can be made of food-grade hose, vertically connected to the cleaning switch 37 through the cleaning inlet, and connected upstream to a high-pressure clean water source. The vertical flushing design generates turbulence, quickly removing residual liquid from the pipe and avoiding cross-contamination between batches of medicine. Manual / automatic dual-mode switching improves operational flexibility.

[0062] Continue to refer to Figure 5 The shunt switch 34 includes a detection inlet, a qualified product outlet, and a defective product outlet. The detection inlet is used to connect to the detection pipeline 31, the qualified product outlet is used to connect to the qualified pipeline 32, and the defective product outlet is used to connect to the defective pipeline 33. The qualified pipeline is connected to the next process.

[0063] In other embodiments, a defective product recycling device, such as a recycling bin, is provided downstream of the defective product pipeline. The defective Chinese medicine liquid in the defective product recycling device can be reprocessed and the concentration can be adjusted to meet the requirements, thereby reducing the waste of medicine.

[0064] Please refer to Figure 5 and Figure 6 In this embodiment, the detection device 38 is a liquid concentration detector and is controlled by communication with the control system 8. The core controller module of the control system 8 has pre-stored the concentration threshold range of different traditional Chinese medicines. When the liquid concentration detector is not within the threshold range for a certain period of time (e.g., 3 seconds), the diversion switch 34 is triggered to switch to the defective product outlet, connecting the detection pipeline and the defective product pipeline for defective product collection and reprocessing.

[0065] For further details, please refer to... Figure 6 In one embodiment, the concentrated solution that has passed the concentration test can be packaged directly when the mixture is generated.

[0066] Specifically, the qualified pipeline 32 is divided into two paths and equipped with solenoid valves that are switched by the control system 8. One path is set as the third vacuum conveying pipe 41 and connected to the input end of the compound packaging device 4 for quantitative packaging of the compound; the other path is the subsequent pipeline of the second vacuum conveying pipe 24, which is used to connect to the input end of the drying and granulation module 5.

[0067] For further details, please refer to... Figure 3 The drying and granulation module 5 is a micro spray dryer granulator, which converts the concentrate into granules through the spray drying process. The processing capacity of the spray dryer granulator is matched and configured to correspond with the micro concentration device 23.

[0068] Please refer to Figure 3The micro spray drying granulator includes a drying tower 52, an atomization system, and a hot air system 53. The atomization system introduces the qualified concentrated liquid from the second vacuum conveying pipe 24 or qualified pipe 32 into the upper part of the drying tower 52 to form droplets. The hot air system 53 includes a burner, a heat exchanger, and a fan to provide a stable high-temperature heat source. The hot air enters the drying tower 52 after filtration. The drying tower 52 is usually made of stainless steel or carbon steel with corrosion-resistant inner walls. The hot air inside the tower comes into contact with the atomized droplets in a countercurrent or parallel flow. The temperature is controlled by the control system 8, for example, the inlet air temperature is 200-300℃, to achieve instantaneous evaporation of moisture and form dried granular products. The dried powder is collected by a cyclone separator 54 and sent to the next process.

[0069] In this embodiment, the processing capacity of the micro spray dryer granulator is matched with that of the micro concentration device 23 to improve processing efficiency. The instantaneous drying of the drying tower 52 reduces energy consumption and stabilizes the moisture content of the particles. Various parameters are adjusted by the control system 8, such as atomization pressure of 0.2-0.8 MPa, inlet air temperature range of 120-180℃, outlet air temperature of 50-70℃, and particle size control of 80-120 mesh.

[0070] For further details, please refer to... Figure 3 The forming module 6 includes a micro tableting device, whose input end is connected to the output end of the drying and granulation module 5 through the fourth vacuum conveying pipe 51. It uses negative pressure to transfer granules and perform tableting. In other embodiments, other mechanical feeding devices can also be used to connect the collecting end of the drying tower 52 and the receiving end of the forming module 6.

[0071] The micro tableting device can be a fully automatic tableting machine. It has a feeding barrel at the top, which is connected to the fourth vacuum conveying pipe 51. The lower end of the feeding barrel is connected to the tableting turntable. The granular material is pressed into tablets or other shapes of medicine through the mold and high pressure punch. Finally, it falls from the inclined tablet discharge slide to be collected and transferred to the next process.

[0072] For further details, please refer to... Figure 6 The solid packaging module 7 is set at the rear end of the forming module 6, such as the aluminum-plastic blister packaging machine in the solid packaging machine. The inclined sheet discharge slide falls directly into the feeding end of the solid packaging machine to seal the fixed forming agent.

[0073] In this embodiment, each vacuum delivery pipe is matched with a corresponding vacuum pump to maintain negative pressure in the pipe. The cross-contamination rate is close to zero through fully enclosed delivery, which greatly improves the transfer efficiency compared to manual transfer.

[0074] Furthermore, in this embodiment, please refer to Figure 1The integrated platform 1 is formed by welding or fixing steel frames to form a closed cabinet. The integrated platform 1 is equipped with opening and closing doors for each module and extends the operating system to the outside of the cabinet, which is convenient for staff to operate from the outside. The production line is fully automated, which improves efficiency and reduces human pollution.

[0075] Secondly, please refer to Figures 1-7 One embodiment provides a method for producing a traditional Chinese medicine preparation conversion device, using the aforementioned micro-integrated production line for intra-herb traditional Chinese medicine prescriptions, comprising the following steps:

[0076] Before manufacturing pharmaceuticals, select Chinese medicinal herbs that meet quality standards, and then screen, wash, and remove impurities. Simultaneously, determine the quantity and proportion of medicinal herbs according to the prescription requirements and therapeutic needs. Typically, the principle of compatibility is adopted, mixing multiple medicinal herbs in a specific ratio.

[0077] S1: Decoction: The medicinal slices are put into the micro decoction device 21 for decoction to produce a soup.

[0078] The prepared Chinese herbal medicine pieces are put into the tank, the parameter library is retrieved to select the corresponding type of medicinal material, and the extraction solution is added accordingly. Generally, the water decoction method is used, and some fat-soluble components are extracted by water extraction and ethanol extraction.

[0079] The heating plate heats the herbs to dissolve their active ingredients, and the control system 8 automatically sets parameters such as water volume, temperature, and time based on the selected herbs.

[0080] The filter basket filters the medicinal materials, and the control system 8 controls the vacuum pump to pump the decoction through the first vacuum delivery pipe 22 to the next process.

[0081] S2: Concentration. The decoction is transferred through the first vacuum delivery pipe 22 to the micro-concentration device 23 and converted into a concentrated liquid.

[0082] The decoction enters the spherical concentration tank 231 through the feed inlet, and the vacuum pump on the concentration tank is started to adjust the pressure inside the spherical concentration tank 231;

[0083] Steam is introduced into the jacket of the spherical concentrator 231 through the steam inlet, which raises the internal temperature and causes the decoction to evaporate. After being condensed by the gas-liquid separator and condenser 233, the water in the medicine evaporates and enters the circulating supply tank 236. The concentrated medicine is collected in the receiving tank 234 to become the desired concentrated liquid.

[0084] The concentrate is led out through the outlet and pumped to the next process through the second vacuum conveying pipe 24. During the concentration process, the control system 8 adjusts and controls parameters such as the flow rate and temperature of the feed, discharge and steam.

[0085] S3: After the decoction is concentrated into a concentrated liquid, the concentration is detected. The control system 8 presets a concentration threshold range. The control system 8 separates the qualified concentrated liquid and the substandard concentrated liquid based on the comparison between the detection data and the preset concentration threshold range.

[0086] During the transportation of the qualified concentrate in the second vacuum delivery pipe 24, it passes through the detection pipe 31. The detection element 38 detects the drug concentration of the concentrate in the pipe and sends the data to the control system 8 for identification.

[0087] The control system 8 presets a concentration threshold range. When the detected concentration of the traditional Chinese medicine does not fall within the threshold range, the shunt switch 34 is controlled to cut off the detection pipeline from the qualified pipeline, and at the same time connects the detection pipeline to the defective pipeline to collect the defective products for further processing. If the detected concentration of the traditional Chinese medicine does not fall within the threshold range, the detection pipeline and the qualified pipeline are kept unobstructed, and the concentrate is sent to the next process.

[0088] S4: Spray drying granulation, the concentrated liquid enters the drying and granulation module 5 through the second vacuum conveying pipe 24 to produce granules;

[0089] Hot air system 53 provides a stable high-temperature heat source. Hot air enters the drying tower 52 after being filtered, maintaining the temperature inside the drying tower 52.

[0090] The concentrate enters the drying tower 52 along a qualified pipeline or the second vacuum conveying pipe 24. The concentrate is atomized into droplets by the atomization system. The hot air in the tower comes into contact with the atomized droplets in a countercurrent or parallel flow to evaporate the moisture and form a dry granular product.

[0091] The dried powder is collected by cyclone separator 54 and sent to the next process.

[0092] S5: Drug forming, the granules are conveyed by vacuum or mechanically transferred to the forming module 6 and pressed into the required shape of the drug;

[0093] In this embodiment, the granules are fed into the feeding barrel of the fully automatic tablet press through the fourth vacuum conveying pipe 51. The tablet press rotates and presses down, and the granular material is pressed into tablets or other shapes of medicine through the mold and high pressure die.

[0094] The rotating tablet press causes the formed drug to fall from the tablet ejection chute and be collected for transfer to the next process.

[0095] S6: Solid packaging. The sheet material falls directly into the feeding end of the solid packaging machine via the ejection chute, and the packaging machine seals and packages the fixed-shaped medicine.

[0096] The entire process of drug preparation is fully automated and controlled using an AI system, along with a controller and PLC system. Each module, pump, switch, and other equipment serves as an actuator, enabling the control system 8 to retrieve the corresponding process parameters based on the selected prescription and intelligently adjust the temperature and time parameters of the micro decoction equipment, the concentration and time parameters of the micro concentration equipment, the temperature and time parameters of the drying and granulation module 5, the pressure parameters of the tableting module, and the material transfer operations in real time. This achieves a highly automated and continuous production process from medicinal slices to prepared compound preparations, granules, or tablets.

[0097] Example 2 differs from Example 1 in that:

[0098] After the concentration of the concentrate is tested, the qualified pipeline is connected to the input end of the compound packaging device 4 to carry out quantitative packaging of the compound, such as liquid medicines like cough syrup.

[0099] Example 3 differs from Example 1 in that:

[0100] After spray drying and granulation, the product is directly packaged into quantitative granules, such as cold medicine granules.

[0101] The above examples illustrate the present invention only to aid in understanding it and are not intended to limit the scope of the invention. Those skilled in the art can make various simple deductions, modifications, or substitutions based on the principles of this invention.

Claims

1. A micro-integrated production line for clinical preparations of traditional Chinese medicine, characterized in that, include: Integration platform (1); The decoction and concentration module (2) includes a micro decoction device (21) and a micro concentration device (23). The micro decoction device (21) is used to decoct Chinese medicine to form a decoction, and the micro concentration device (23) is used to concentrate the decoction to form a concentrated liquid. The input end of the micro concentration device (23) is connected to the output end of the micro decoction device (21) through a first vacuum delivery pipe (22). The first vacuum delivery pipe (22) maintains a negative pressure to transfer the concentrated liquid. The drying and granulation module (5) has its input end connected to the output end of the micro-concentrating device (23) via a second vacuum delivery pipe (24), and is used to receive the concentrate and make it into granules; The molding module (6) has its input end connected to the output end of the drying and granulation module (5) and is used to press the granules into shape. as well as The control system (8) has a pre-stored database of process parameters for different medicinal materials. It is connected to the decoction and concentration module (2), the drying and granulation module (5), the forming module (6), the first vacuum conveying pipe (22), and the second vacuum conveying pipe (24) in real time, and controls the actions and parameters in the decoction, concentration, drying, tableting and conveying processes.

2. The micro-integrated production line for clinical preparations of traditional Chinese medicine as described in claim 1, characterized in that, It also includes a process concentration detection module (3), which is located between the decoction and concentration module (2) and the drying and granulation module (5). The process concentration detection module (3) is connected to the control system (8) and is used to detect the drug concentration of the concentrate and to separate qualified concentrate and substandard concentrate.

3. The micro-integrated production line for traditional Chinese medicine prescriptions as described in claim 2, characterized in that, The process concentration detection module (3) includes a detection pipeline (31), a qualified pipeline (32), a defective pipeline (33), and a diversion switch (34). One end of the detection pipeline (31) is connected to the output end of the micro-concentrator (23), and the other end is connected to the qualified pipeline (32) and the defective pipeline (33) through the diversion switch (34). The detection pipeline (31) is equipped with a detection element (38) for detecting liquid concentration. The detection element (38) and the diversion switch (34) are controlled by the control system (8) to switch the pipelines to divert qualified concentrate and defective concentrate.

4. The micro-integrated production line for clinical preparations of traditional Chinese medicine as described in claim 3, characterized in that, The process concentration detection module (3) also includes a cleaning pipe (35) and a cleaning switch (37). One end of the cleaning pipe (35) is connected to a water source, and the other end is connected to the output end of the cleaning switch (37) and the micro-concentrator (23). The cleaning switch (37) is controlled by the control system (8) to switch the pipe to clean the pipe (35).

5. The micro-integrated production line for traditional Chinese medicine prescriptions as described in any one of claims 1-4, characterized in that, The micro-concentration device (23) is equipped with a compound preparation packaging device (4). The input end of the compound preparation packaging device (4) is connected to the output end of the micro-concentration device (23) through a third vacuum delivery pipe (41) and is used to package a quantitative compound preparation medicine.

6. The micro-integrated production line for traditional Chinese medicine prescriptions as described in any one of claims 1-4, characterized in that, The drying and granulation module (5) is a micro spray dryer, which converts the concentrate into granules through a spray drying process, and the processing capacity of the spray dryer is matched with that of the micro concentration device (23).

7. The micro-integrated production line for traditional Chinese medicine prescriptions as described in any one of claims 1-4, characterized in that, The forming module (6) includes a micro tableting device, the input end of which is connected to the output end of the drying and granulation module (5) through a fourth vacuum delivery pipe (51), and the granules are transferred by negative pressure and tableted.

8. The micro-integrated production line for traditional Chinese medicine prescriptions as described in any one of claims 1-4, characterized in that, It also includes a solid packaging module (7) disposed at the output end of the molding module (6), the solid packaging module (7) being used to seal and package the fixed molding agent.

9. A production method for a traditional Chinese medicine preparation conversion device, characterized in that, The micro-integrated production line for traditional Chinese medicine prescriptions as described in any one of claims 1-8 includes the following steps: Decoction: The medicinal slices are put into a micro decoction device (21) for decoction to generate a soup; Concentration: The decoction is transferred through the first vacuum delivery tube (22) to the micro-concentration device (23) to generate a concentrated liquid; Spray drying granulation: The concentrated liquid enters the drying granulation module (5) through the second vacuum conveying pipe (24) to produce granules; Pharmaceutical formulation: Granules are conveyed by vacuum or mechanically transferred to the forming module (6) and pressed into the required shape or directly enter the packaging process; The entire process is controlled by the control system (8), which adjusts the actions and parameters in the decoction, concentration, drying, shaping and transportation processes in real time to complete the conversion of medicinal slices into compound preparations, granules or tablets.

10. The production method of the traditional Chinese medicine preparation conversion device as described in claim 9, characterized in that, After the decoction is concentrated to form a concentrated liquid, the concentration is detected. The control system (8) presets a concentration threshold range. The control system (8) separates qualified concentrated liquid and substandard concentrated liquid based on the comparison between the detection data and the preset concentration threshold range.

Images