Magnetic coupling precision liquid balance unit and magnetic coupling precision liquid balance control device

Abstract

A magnetically coupled precise liquid balance unit and a magnetically coupled precise liquid balance control device include an injection cylinder (1-1), a magnetically coupled driven component (1-2), and a magnetically coupled active component (1-3). The first end of the injection cylinder (1-1) has a first fluid inlet / outlet (1-4), and the second end of the injection cylinder (1-1) has a second fluid inlet / outlet (1-5). The magnetically coupled driven component (1-2) is located inside the injection cylinder (1-1) and divides the cavity of the injection cylinder (1-1) into a first inlet / outlet fluid cavity (1-6) and a second inlet / outlet fluid cavity (1-7). The magnetically coupled active component (1-3) is located outside the injection cylinder (1-1). The magnetically coupled active component (1-3) and the magnetically coupled driven component (1-2) interact with each other through magnetic force, and when the magnetically coupled active component (1-3) moves, it drives the magnetically coupled driven component (1-2) to reciprocate within the injection cylinder (1-1) through magnetic force. This magnetically coupled precision liquid balance unit can reduce the difference in fluid volume between the human body and the fluid during a single replenishment, greatly extending the continuous and reliable working time of the magnetically coupled precision liquid balance unit and the magnetically coupled precision liquid balance control device.

Description

Technical Field

[0001] This invention relates to the field of medical device technology. Specifically, it relates to a magnetically coupled precision liquid balance unit and a magnetically coupled precision liquid balance control device. Background Technology

[0002] Continuous Renal Replacement Therapy (CRRT), also known as Continuous Blood Purification (CBP), is a long-term, continuous extracorporeal blood purification therapy that uses blood to replace damaged kidney function, 24 hours a day. The clinical goals of CRRT are to remove excess water from the body, eliminate metabolic end products, toxins, certain cytokines and inflammatory mediators, correct electrolyte and acid-base imbalances, and promote the recovery of kidney function. CRRT is mainly used clinically for the treatment of acute and chronic renal failure, multiple organ dysfunction syndrome, acute respiratory distress syndrome, crush syndrome, acute hemorrhagic necrotizing pancreatitis, chronic heart failure, hepatic encephalopathy, and drug or poisoning.

[0003] During CRRT treatment, the total daily replacement fluid volume typically ranges from tens of liters to over 100 liters. Ensuring a balance between replacement fluid and effluent fluid volume, and precise dehydration, is crucial for ensuring treatment safety. Because the total volume of fluid entering and leaving the extracorporeal circulation during treatment is substantial, even a 1% error in fluid inflow or outflow can result in an absolute error of hundreds of milliliters or more, causing severe fluid imbalance. On the one hand, excessive replacement fluid infusion can lead to volume overload and heart failure; on the other hand, excessive dehydration can cause hypovolemia, resulting in hypotension and shock. In short, fluid imbalance can have fatal consequences.

[0004] Currently, the main manufacturers of CRRT equipment on the market include B. Braun and Fresenius from Germany, Asahi Kasei from Japan, and Baxter from the United States. These CRRT machines control the rate and volume of fluid entering the extracorporeal circulation via replacement fluid / dialysis fluid pumps, and the rate and volume of fluid leaving the extracorporeal circulation via waste fluid pumps. Simultaneously, the equipment uses multiple weighing scales to monitor the weight of the replacement fluid bag, dialysis fluid bag, and waste fluid bag in real time. Through pump feedback, the speeds of the replacement pump, dialysis pump, and waste fluid pump are adjusted to control the total amount of fluid entering and leaving the extracorporeal circulation, achieving fluid balance and quantitative dehydration.

[0005] However, the existing technical solutions mentioned above have many shortcomings and defects. First, the weighing scale requires frequent calibration to achieve the required accuracy, and its accuracy becomes uncertain as the machine ages. Second, weight detection can only be performed in a static state; any shaking of the bag will cause the weighing scale to malfunction. Third, frequent bag changes are required during treatment, significantly increasing the workload of nursing care.

[0006] In addition, all current CRRT technical solutions generate negative pressure by rotating the rotor rollers and crushing the pump tubes to achieve the power of liquid flow. The rotor rollers are usually consumable parts, and mechanical wear is inevitable after long-term use, which will affect the flow error.

[0007] Therefore, CRRT equipment requires more reliable and precise liquid balance control technology.

[0008] Chinese patent document CN203169682U discloses a portable multi-organ function support integrated treatment machine. Both the replenishing fluid and the waste fluid are subjected to varying degrees of compression when entering the first rigid cavity 210 and the second rigid cavity 220. Since trace amounts of gas inevitably mix into both the replenishing and waste fluids, their compressibility is significantly reduced. Furthermore, the rigid cavities inevitably undergo slight volume changes under internal liquid pressure, resulting in a small difference between the replenishing and waste fluid volumes in adjacent entries into the same rigid cavity. This small difference does not have a significant negative impact on the patient when the replenishing volume is small. However, in the case of prolonged continuous treatment, the replenishing volume will be very large. Even if this small difference is only 0.1 mL, a replenishing volume of 1000 mL can produce a 100 mL difference in the volume of fluid entering and leaving the body. As this difference in the volume of fluid entering and leaving the body accumulates further, it will endanger the patient's life. For example, when a patient undergoes dialysis or blood exchange, the amount of fluid entering and leaving the patient's body can reach about two liters per hour. A difference of 0.1 mL in each fluid replacement will result in a 100 mL difference in fluid volume within one hour. Some patients require about four liters per hour, and a difference of 0.1 mL in each replacement will result in a 400 mL difference within one hour. Other patients require about 100 liters per day, and a difference of 0.1 mL in each replacement will result in a 10 L difference in fluid volume within one day. Such fluid imbalance can lead to fatal consequences. Summary of the Invention

[0009] Therefore, the technical problem to be solved by the present invention is to provide a more reliable and accurate magnetically coupled precise liquid balance control unit and magnetically coupled precise liquid balance control device, thereby reducing the difference in liquid volume between the human body and the fluid volume per unit replenishment volume, and extending the continuous and reliable working time of the magnetically coupled precise liquid balance unit and magnetically coupled precise liquid balance control device.

[0010] To solve the above-mentioned technical problems, the present invention provides the following technical solution:

[0011] A magnetically coupled precision liquid balancing unit includes an injection cylinder, a magnetically coupled driven component, and a magnetically coupled active component. The injection cylinder has a first fluid inlet / outlet at its first end and a second fluid inlet / outlet at its second end. The magnetically coupled driven component is located inside the injection cylinder and divides the cylinder's accommodating cavity into a first inlet / outlet fluid accommodating cavity and a second inlet / outlet fluid accommodating cavity. The contact surface between the magnetically coupled driven component and the inner wall of the injection cylinder is fluid-sealed. The magnetically coupled active component is located outside the injection cylinder. The active component and the driven component interact magnetically, and the active component's movement drives the driven component to reciprocate within the injection cylinder. When the driven component pushes fluid out of the first inlet / outlet fluid accommodating cavity through the first fluid inlet / outlet, fluid is drawn into the second inlet / outlet fluid accommodating cavity through the second fluid inlet / outlet. When the driven component pushes out the second inlet / outlet fluid accommodating cavity through the second fluid inlet / outlet, liquid is drawn into the first inlet / outlet fluid accommodating cavity through the first fluid inlet / outlet.

[0012] In the aforementioned magnetically coupled precision liquid balance unit, the cross-section of the receiving cavity of the syringe is a rounded rectangle or a circle.

[0013] In the aforementioned magnetically coupled precision liquid balance unit, the magnetically coupled driven component is an electrical pure iron, ferrite, or permanent magnet, and the magnetically coupled active component can be an electromagnet or a rare-earth permanent magnet. The magnetically coupled active component and the magnetically coupled driven component attract each other to form a magnetic coupling force. When the magnetically coupled driven component reciprocates within the injection cylinder, the resistance overcome when the first fluid inlet / outlet cavity pushes out fluid through the first fluid inlet / outlet or when the second fluid inlet / outlet cavity pushes out fluid through the second fluid inlet / outlet is greater than or equal to 450 mmHg, and the resistance overcome when the second fluid inlet / outlet cavity draws in fluid through the second fluid inlet / outlet or when the first fluid inlet / outlet cavity passes through the first fluid inlet / outlet is less than or equal to -450 mmHg.

[0014] In the aforementioned magnetically coupled precision liquid balance unit, a sealing ring is installed on the surface of the magnetically coupled driven component that contacts the inner wall of the syringe; the syringe wall is wholly or partially transparent or semi-transparent, and the inner wall of the syringe has a hydrophilic coating.

[0015] The aforementioned magnetically coupled precision liquid balancing unit further includes a stepper motor, a bracket, a slide rail, a slider, a screw, a limiting mechanism, a stroke detection mechanism, and a decoupling detection mechanism. The slide rail is mounted on the bracket, the slider is located on the slide rail, and the screw passes through a threaded hole on the slider. The stepper motor drives the screw to rotate in both directions, and the screw drives the slider to reciprocate linearly along the slide rail. There are two limiting mechanisms, located at the end of the forward stroke and the end of the reverse stroke of the slider, respectively. The stroke detection mechanism determines the stroke distance of the slider by the number of rotations of the screw. The magnetically coupled active component is mounted on the slider, and the decoupling detection mechanism is mounted on the slider adjacent to the magnetically coupled active component.

[0016] The aforementioned magnetically coupled precision liquid balancing unit includes a support comprising a left vertical plate, a right vertical plate, and a base plate. The left and right vertical plates are respectively fixedly mounted on two opposite side edges of the base plate. The two ends of the screw are respectively mounted on bearings on the left and right vertical plates. The stepper motor is fixedly mounted on the left vertical plate. The slide rail is mounted on the base plate and located between the left and right vertical plates. Two limiting mechanisms are respectively mounted on the left and right vertical plates. The top of the slider has an upward-opening U-shaped coupling seat. The magnetically coupled active component and the decoupling detection mechanism are both mounted on the U-shaped coupling seat. The two ends of the syringe are respectively mounted on the left and right vertical plates, and a portion of the syringe is located within the U-shaped space of the U-shaped coupling seat.

[0017] The aforementioned magnetically coupled precise liquid balance control device includes a waste liquid outlet pipe, an external input liquid inlet pipe, a waste liquid outlet pipe, an external input liquid container, a first clamp valve, a second clamp valve, a third clamp valve, a fourth clamp valve, and the aforementioned magnetically coupled precise liquid balance unit. The first end of the waste liquid outlet pipe is fluidly connected to the waste liquid outlet of the blood filter, and the second end of the waste liquid outlet pipe is fluidly connected to the waste liquid outlet pipe. The third clamp valve is located on the waste liquid outlet pipe and installed adjacent to the second end of the waste liquid outlet pipe. The first end of the waste liquid outlet pipe is fluidly connected to the second fluid inlet and outlet, and the second end of the waste liquid outlet pipe is fluidly connected to the waste liquid container. The fourth clamp valve is adjacent to the waste liquid container and the waste liquid outlet pipe and the waste liquid outlet pipe. The waste liquid discharge pipe is installed between the outlet pipe connection nodes; when the external input liquid is a replacement fluid: the first end of the external input liquid inlet pipe is fluidly connected to the blood outlet pipe or blood inlet pipe of the blood filter; when the external input liquid is a dialysate: the first end of the external input liquid inlet pipe is fluidly connected to the dialysate inlet of the blood filter, the second end of the external input liquid inlet pipe is fluidly connected to the first fluid inlet and outlet; the second pinch valve is installed near the external input liquid supply pipe that is fluidly connected between the external input liquid container and the external input liquid inlet pipe; the first pinch valve is installed near the external input liquid inlet pipe between the blood outlet pipe and the external input liquid supply pipe and the external input liquid inlet pipe connection node.

[0018] When the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the first clamp valve opens, the second clamp valve closes, the third clamp valve opens, and the fourth clamp valve closes. When the external input fluid is a replacement fluid: the external input fluid in the first inlet and outlet fluid receiving chamber is discharged from the first fluid inlet and outlet to the blood outlet pipe to enter the human body or discharged to the blood inlet pipe to dilute the blood about to enter the blood filter. When the external input fluid is a dialysate: the external input fluid in the first inlet and outlet fluid receiving chamber is discharged from the first fluid inlet and outlet to the dialysate inlet of the blood filter, while the waste liquid in the blood filter is drawn into the second inlet and outlet fluid receiving chamber. When the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the first clamp valve closes, the second clamp valve opens, the third clamp valve closes, and the fourth clamp valve opens. The external input fluid enters the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while the waste liquid in the second inlet and outlet fluid receiving chamber is discharged into the waste liquid container.

[0019] The aforementioned magnetically coupled precise liquid balance control device, from the blood filter to the third clamp valve: a second pressure sensor and a blood leakage sensor are sequentially installed on the waste liquid outlet pipe; a first pressure sensor is installed on the external input liquid inlet pipe between the first clamp valve and the blood outlet pipe; and a liquid air detector is installed on the external input liquid supply pipe between the second clamp valve and the external input liquid container.

[0020] The aforementioned magnetically coupled precise liquid balance control device includes a waste liquid outlet pipe, a waste liquid discharge pipe, a first clamp valve, a second clamp valve, and the aforementioned magnetically coupled precise liquid balance unit; the first end of the waste liquid outlet pipe is fluidly connected to the waste liquid outlet of the blood filter, the second end of the waste liquid outlet pipe is fluidly connected to the waste liquid discharge pipe, the first clamp valve is installed adjacent to the second end of the waste liquid outlet pipe, the first end of the waste liquid discharge pipe is fluidly connected to the second fluid inlet and outlet, the second end of the waste liquid discharge pipe is fluidly connected to the waste liquid container, the second clamp valve is installed adjacent to the waste liquid discharge pipe between the waste liquid container and the connection node of the waste liquid outlet pipe and the waste liquid discharge pipe, and the first fluid inlet and outlet are fluidly connected to the external atmosphere;

[0021] When the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the first clamp valve opens and the second clamp valve closes, allowing the gas in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet, while simultaneously drawing the waste liquid in the blood filter into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the first clamp valve closes and the second clamp valve opens, allowing external gas to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while simultaneously discharging the waste liquid in the second inlet and outlet fluid receiving chamber into the waste liquid container.

[0022] The aforementioned magnetically coupled precision liquid balance control device has a first pressure sensor and a blood leakage sensor sequentially installed on the waste liquid outlet pipe from the waste liquid outlet of the blood filter to the first clamp valve.

[0023] The aforementioned magnetically coupled precise liquid balance control device includes a fifth clamp valve, a sixth clamp valve, a net dehydration discharge pipe, the aforementioned magnetically coupled precise liquid balance unit, and the aforementioned magnetically coupled precise liquid balance control device. The external input liquid is a displacement fluid. The magnetically coupled precise liquid balance unit in the aforementioned magnetically coupled precise liquid balance control device is a first magnetically coupled precise liquid balance unit, and the aforementioned magnetically coupled precise liquid balance unit is a second magnetically coupled precise liquid balance unit. The first end of the net dehydration discharge pipe is fluidly connected to the second fluid inlet and outlet of the second magnetically coupled precise liquid balance unit, and the second end of the net dehydration discharge pipe is fluidly connected to the waste liquid container. The net dehydration discharge pipe and the waste liquid outlet pipe are fluidly connected through a branch pipe, and the fifth clamp valve is installed adjacent to the branch pipe. The sixth clamp valve is installed adjacent to the waste liquid container and the net dehydration discharge pipe at the connection point between the net dehydration discharge pipe and the branch pipe.

[0024] In the first magnetically coupled precision liquid balance unit: when the magnetically coupled driven component moves towards the direction adjacent to the first fluid inlet and outlet, the first clamp valve opens, the second clamp valve closes, the third clamp valve opens, and the fourth clamp valve closes, allowing the replacement fluid in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet to the blood outlet pipe and enter the human body, or discharged into the blood inlet pipe and enter the blood filter to achieve pre-dilution of the replacement fluid. At the same time, the waste liquid in the blood filter is drawn into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves towards the direction adjacent to the second fluid inlet and outlet, the first clamp valve closes, the second clamp valve opens, the third clamp valve closes, and the fourth clamp valve opens, allowing the replacement fluid to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while the waste liquid in the second inlet and outlet fluid receiving chamber is discharged into the waste liquid container;

[0025] In the second magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the fifth clamp valve opens and the sixth clamp valve closes, allowing the gas in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet, while simultaneously drawing the waste liquid in the blood filter into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the fifth clamp valve closes and the sixth clamp valve opens, allowing external gas to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while simultaneously discharging the waste liquid in the second inlet and outlet fluid receiving chamber into the waste liquid container.

[0026] The aforementioned magnetically coupled precise liquid balance control device includes a fifth clamp valve, a sixth clamp valve, a net dehydration discharge pipe, the aforementioned magnetically coupled precise liquid balance unit, and the aforementioned magnetically coupled precise liquid balance control device. The external input liquid is dialysate. The magnetically coupled precise liquid balance unit in the aforementioned magnetically coupled precise liquid balance control device is a first magnetically coupled precise liquid balance unit, and the aforementioned magnetically coupled precise liquid balance unit is a second magnetically coupled precise liquid balance unit. The first end of the net dehydration discharge pipe is fluidly connected to the second fluid inlet and outlet of the second magnetically coupled precise liquid balance unit, and the second end of the net dehydration discharge pipe is fluidly connected to the waste liquid container. The net dehydration discharge pipe and the waste liquid outlet pipe are fluidly connected through a branch pipe, and the fifth clamp valve is installed adjacent to the branch pipe. The sixth clamp valve is installed adjacent to the net dehydration discharge pipe between the waste liquid container and the connection node of the net dehydration discharge pipe and the branch pipe.

[0027] In the first magnetically coupled precision liquid balance unit: when the magnetically coupled driven component moves towards the direction adjacent to the first fluid inlet and outlet, the first clamp valve opens, the second clamp valve closes, the third clamp valve opens, and the fourth clamp valve closes, allowing the dialysate in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet through the dialysate inlet into the blood filter to exchange solutes with the blood in the hollow fiber membrane. At the same time, the dialysate that has undergone solute exchange in the blood filter is regarded as waste liquid and is drawn from the dialysate outlet into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves towards the direction adjacent to the second fluid inlet and outlet, the first clamp valve closes, the second clamp valve opens, the third clamp valve closes, and the fourth clamp valve opens, allowing the dialysate to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while the waste liquid in the second inlet and outlet fluid receiving chamber is discharged into the waste liquid container;

[0028] In the second magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the fifth clamp valve opens and the sixth clamp valve closes, allowing the gas in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet, while simultaneously drawing the waste liquid in the blood filter into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the fifth clamp valve closes and the sixth clamp valve opens, allowing external gas to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while simultaneously discharging the waste liquid in the second inlet and outlet fluid receiving chamber into the waste liquid container.

[0029] The aforementioned magnetically coupled precise liquid balance control device includes a fifth clamp valve, a sixth clamp valve, a net dehydration discharge pipe, one magnetically coupled precise liquid balance unit, and two magnetically coupled precise liquid balance control devices. The two magnetically coupled precise liquid balance control devices share a single waste liquid discharge pipe. The external input liquid in the first magnetically coupled precise liquid balance control device is a replacement fluid, and the magnetically coupled precise liquid balance unit therein is a first magnetically coupled precise liquid balance unit. The external input liquid in the second magnetically coupled precise liquid balance control device is dialysis fluid, and the magnetically coupled precise liquid balance unit therein is a second magnetically coupled precise liquid balance unit. The first, second, third, and fourth clamp valves in the device are sequentially named the seventh, eighth, ninth, and tenth clamp valves, respectively. The aforementioned magnetically coupled precise liquid balancing unit is the third magnetically coupled precise liquid balancing unit. The first end of the net dehydration discharge pipe is fluidly connected to the second fluid inlet and outlet of the third magnetically coupled precise liquid balancing unit, and the second end of the net dehydration discharge pipe is fluidly connected to the waste liquid container. The net dehydration discharge pipe and the waste liquid outlet pipe are fluidly connected through a branch pipe, and the fifth clamp valve is installed adjacent to the branch pipe. The sixth clamp valve is installed adjacent to the waste liquid container and the net dehydration discharge pipe at the connection point between the net dehydration discharge pipe and the branch pipe.

[0030] In the first magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the first clamp valve opens, the second clamp valve closes, the third clamp valve opens, and the fourth clamp valve closes, allowing the replacement fluid in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet to the blood outlet tube and enter the human body, while simultaneously drawing the waste fluid in the blood filter into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the first clamp valve closes, the second clamp valve opens, the third clamp valve closes, and the fourth clamp valve opens, allowing the replacement fluid to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while simultaneously discharging the waste fluid in the second inlet and outlet fluid receiving chamber into the waste fluid container;

[0031] In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component moves towards the direction adjacent to the first fluid inlet and outlet, the seventh clamp valve opens, the eighth clamp valve closes, the ninth clamp valve opens, and the tenth clamp valve closes, allowing the dialysate in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet through the dialysate inlet into the blood filter to exchange solutes with the blood in the hollow fiber membrane. At the same time, the dialysate that has undergone solute exchange in the blood filter is treated as waste liquid and pumped into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves towards the direction adjacent to the second fluid inlet and outlet, the seventh clamp valve closes, the eighth clamp valve opens, the ninth clamp valve closes, and the tenth clamp valve opens, allowing the dialysate to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while the waste liquid in the second inlet and outlet fluid receiving chamber is discharged into the waste liquid container;

[0032] In the third magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component moves toward the direction adjacent to the first fluid inlet and outlet, the fifth clamp valve opens and the sixth clamp valve closes, allowing the gas in the first inlet and outlet fluid receiving chamber to be discharged from the first fluid inlet and outlet, while simultaneously drawing the waste liquid in the blood filter into the second inlet and outlet fluid receiving chamber; when the magnetically coupled driven component moves toward the direction adjacent to the second fluid inlet and outlet, the fifth clamp valve closes and the sixth clamp valve opens, allowing external gas to enter the first inlet and outlet fluid receiving chamber from the first fluid inlet and outlet, while simultaneously discharging the waste liquid in the second inlet and outlet fluid receiving chamber into the waste liquid container.

[0033] The technical solution of the present invention achieves the following beneficial technical effects:

[0034] 1. Both replenishment and waste liquid are drawn into the syringe through vacuum negative pressure and naturally fill the syringe's capacity without being compressed. This significantly reduces the volume difference between replenishment and waste liquid entering the syringe between adjacent injections due to reduced compressibility caused by trace amounts of gas mixed in the replenishment and / or waste liquid. It also solves the problem of increased volume caused by increased internal pressure in the syringe. This reduces the volume difference between the inflow and outflow of liquid per unit replenishment volume, greatly extending the continuous and reliable working time of the magnetically coupled precise liquid balance unit and the magnetically coupled precise liquid balance control device.

[0035] 2. The sealing ring serves to seal and prevent liquid leakage. It is made of self-lubricating material with a hydrophilic coating to reduce frictional resistance. When the magnetically coupled precision liquid balance unit is working, the resistance overcome when pushing out liquid should be greater than 450 mmHg; the resistance overcome when pumping in liquid should be less than -450 mmHg.

[0036] The size of the syringe is matched to the actual required liquid injection speed [in practice, this can be designed independently without creative effort]. For example, approximately 1 mL of liquid is drawn in or ejected for every 1 mm movement of the slider; this can be adjusted by changing the travel speed or the size of the syringe; the cross-sectional shape of the syringe can be rectangular, elliptical, or cylindrical, etc.

[0037] The inner diameter of the syringe and the cross-sectional area at both ends must be exactly the same. It should be transparent or semi-transparent to facilitate visual observation when the slider moves. The syringe and its internal magnetic piston (outer coating) are made of self-lubricating materials (such as polycarbonate + polytetrafluoroethylene), which have good biocompatibility, are non-toxic, and meet medical requirements. The inner wall surface of the syringe has a hydrophilic coating to reduce friction between it and the slider. Attached Figure Description

[0038] Figure 1 A schematic diagram of the structure of the first magnetically coupled precise liquid balance control device of the present invention;

[0039] Figure 2 A schematic diagram of the structure of the second type of magnetically coupled precise liquid balance control device of the present invention;

[0040] Figure 3 A schematic diagram of the structure of the third type of magnetically coupled precise liquid balance control device of the present invention;

[0041] Figure 4 A schematic diagram of the fourth type of magnetically coupled precise liquid balance control device of the present invention;

[0042] Figure 5 A schematic diagram of the fifth type of magnetically coupled precise liquid balance control device of the present invention;

[0043] Figure 6 A schematic diagram of the magnetically coupled precision liquid balance unit of this invention;

[0044] Figure 7 for Figure 6 The diagram shows a structural schematic of the magnetically coupled precision liquid balance unit from another angle.

[0045] Figure 8 A schematic diagram of the longitudinal section of the injection chamber of the magnetically coupled precision liquid balance unit of the present invention.

[0046] The reference numerals in the figure are as follows: 1-1-Injection cylinder; 1-2-Magnetic coupling driven component; 1-3-Magnetic coupling active component; 1-4-First fluid inlet / outlet; 1-5-Second fluid inlet / outlet; 1-6-First inlet / outlet fluid receiving cavity; 1-7-Second inlet / outlet fluid receiving cavity; 1-8-Stepper motor; 1-9-Bracket; 1-10-Slide rail; 1-11-Slider; 1-12-Screw; 1-13-Limiting mechanism; 1-14-Stroke detection mechanism; 1-15-Decoupling detection mechanism; 1-16-Left upright plate; 1-17-Right upright plate; 1-18-Base plate; 1-19-U-shaped coupling seat.

[0047] 2-1 Waste liquid outlet pipe; 2-2 External input fluid inlet pipe; 2-3 Waste liquid outlet pipe; 2-4 External input fluid container; 2-5 First clamp valve; 2-6 Second clamp valve; 2-7 Third clamp valve; 2-8 Fourth clamp valve; 2-9 Blood filter; 2-10 Waste liquid container; 2-11 External input fluid supply pipe; 2-12 Blood outlet pipe; 2-13 Blood inlet pipe; 2-14 Second pressure sensor; 2-15 Blood leakage sensor ; 2-16-First pressure sensor; 2-17-Liquid air detector; 2-18-Pre-dilution tube for replacement fluid; 2-19-External input fluid weighing sensor; 2-20-Fifth pinch valve; 2-21-Sixth pinch valve; 2-22-Net dehydration discharge tube; 2-23-Seventh pinch valve; 2-24-Eighth pinch valve; 2-25-Ninth pinch valve; 2-26-Tenth pinch valve; 2-27-Third pressure sensor; 2-28-Replacement fluid; 2-29-Dialysis fluid. Detailed Implementation

[0048] Example 1

[0049] like Figures 6 to 8As shown, the magnetically coupled precision liquid balance unit of this embodiment includes an injection cylinder 1-1, a magnetically coupled driven component 1-2, and a magnetically coupled active component 1-3. The injection cylinder 1-1 has a first fluid inlet / outlet 1-4 at its first end and a second fluid inlet / outlet 1-5 at its second end. The magnetically coupled driven component 1-2 is located inside the injection cylinder 1-1 and divides the cavity of the injection cylinder 1-1 into a first fluid inlet / outlet cavity 1-6 and a second fluid inlet / outlet cavity 1-7. The contact surface between the magnetically coupled driven component 1-2 and the inner wall of the injection cylinder 1-1 is fluid-sealed. The magnetically coupled active component 1-3 is located outside the injection cylinder 1-1. The magnetically coupled driven component 1-2 interacts with the magnetically coupled driven component 1-2 through magnetic force, and when the magnetically coupled active component 1-3 moves, it drives the magnetically coupled driven component 1-2 to reciprocate within the injection cylinder 1-1 through magnetic force; when the magnetically coupled driven component 1-2 pushes out the fluid in the first inlet / outlet fluid receiving cavity 1-6 through the first fluid inlet / outlet 1-4, the second inlet / outlet fluid receiving cavity 1-7 draws in fluid through the second fluid inlet / outlet 1-5; or when the magnetically coupled driven component 1-2 pushes out the second inlet / outlet fluid receiving cavity 1-7 through the second fluid inlet / outlet 1-5, the first inlet / outlet fluid receiving cavity 1-6 draws in liquid through the first fluid inlet / outlet 1-4. Since the magnetic force decreases very rapidly with distance, the distance between the magnetically coupled driven component 1-2 and the magnetically coupled active component 1-3 should preferably not exceed 3 mm. For example, if the wall thickness of the syringe is 2 mm and the gap between the magnetically coupled active component and the outer wall of the syringe is 0.5 mm, it can be ensured that the magnetic force between the magnetically coupled active component and the magnetically coupled driven component is sufficiently reliable to drive the magnetically coupled driven component to reciprocate within the syringe.

[0050] In this embodiment, the magnetically coupled driven component 1-2 is made of electrical pure iron, ferrite, or a permanent magnet, and the magnetically coupled active component 1-3 can be an electromagnet or a rare-earth permanent magnet [given that the syringe and its internal components are disposable, the price of a rare-earth permanent magnet would be too high for cost reduction and environmental protection considerations]. The magnetically coupled active component 1-3 and the magnetically coupled driven component 2 attract each other to form a magnetic coupling force. When the magnetically coupled driven component 2 reciprocates within the syringe 1-1, it causes the first fluid inlet / outlet cavity 1-6 to eject fluid through the first fluid inlet / outlet 1-4, or it causes the second fluid inlet / outlet cavity 1-7 to pass through the second fluid inlet / outlet. When fluid is pushed out of inlet / outlet 1-5, the resistance overcome is greater than or equal to 450 mmHg [the sealing ring on the magnetically coupled driven component has sealing pressure. If the sealing pressure of the sealing ring is too small, a reliable sealing effect cannot be achieved. If the sealing pressure is too large, the movement resistance of the magnetically coupled driven component will be too large, and the magnetically coupled active component will not be able to drive the magnetically coupled driven component. This is a requirement for the sealing performance of the sealing ring]. This ensures that when the second fluid inlet / outlet receiving cavity 1-7 draws in fluid through the second fluid inlet / outlet 1-5, or when the first fluid inlet / outlet receiving cavity 1-6 draws in liquid through the first fluid inlet / outlet 1-4, the resistance overcome is less than or equal to -450 mmHg [it is easy to draw in liquid. This is a requirement for the pressure resistance of the sealing ring].

[0051] A sealing ring is installed on the surface of the magnetically coupled driven component 1-2 that contacts the inner wall of the injection cylinder 1-1; the cylinder wall of the injection cylinder 1-1 is wholly or partially transparent or semi-transparent, and the inner wall of the injection cylinder 1-1 has a hydrophilic coating.

[0052] like Figure 6 and Figure 7As shown, the magnetically coupled precision liquid balance unit in this embodiment also includes a stepper motor 1-8, a bracket 1-9, a slide rail 1-10, a slider 1-11, a screw 1-12, a limit mechanism 1-13 (which can be a micro switch, triggering to stop movement), a stroke detection mechanism 1-14 (which can be an encoder or a sliding resistor), and a decoupling detection mechanism 1-15 (which can be a photoelectric switch or a photoelectric sensor, detecting whether the magnetically coupled driven component moves with the magnetically coupled active component). The slide rail 1-10 is mounted on the bracket 1-9, the slider 1-11 is located on the slide rail 1-10, and the screw 1-12 passes through the slider 1-11. The stepper motor 1-8 drives the screw 1-12 to rotate in both directions, and the screw 1-12 drives the slider 1-11 to reciprocate linearly along the slide rail 1-10. There are two limiting mechanisms 1-13, which are located at the end of the forward stroke and the end of the reverse stroke of the slider 1-11, respectively. The stroke detection mechanism 1-14 determines the stroke distance of the slider 1-11 by the number of rotations of the screw 1-12. The magnetic coupling active component 1-3 is installed on the slider 1-11, and the decoupling detection mechanism 1-15 is installed on the slider 1-11 adjacent to the magnetic coupling active component 1-3. The bracket 1-9 includes a left upright plate 1-16, a right upright plate 1-17, and a base plate 1-18. The left upright plate 1-16 and the right upright plate 1-17 are respectively fixedly installed on two opposite side edges of the base plate 1-18. The two ends of the screw 1-12 are respectively installed on bearings on the left upright plate 1-16 and the right upright plate 1-17. The stepper motor 1-8 is fixedly installed on the left upright plate 1-16. The slide rail 1-10 is installed on the base plate 1-18 and located between the left upright plate 1-16 and the right upright plate 1-17. Between them, the two limiting mechanisms 1-13 are respectively installed on the left upright plate 1-16 and the right upright plate 1-17. The top of the slider 1-11 has an upward-opening U-shaped coupling seat 1-19. The magnetic coupling active component 1-3 and the decoupling detection mechanism 1-15 are both installed on the U-shaped coupling seat 1-19. The two ends of the injection cylinder 1-1 are respectively installed on the left upright plate 1-16 and the right upright plate 1-17, and a part of the injection cylinder 1-1 is located in the U-shaped space of the U-shaped coupling seat 1-19.

[0053] Example 2

[0054] like Figure 1As shown, the magnetically coupled precise liquid balance control device of this embodiment includes a waste liquid outlet pipe 2-1, an external input liquid inlet pipe 2-2, a waste liquid outlet pipe 2-3, an external input liquid container 2-4, a first clamp valve 2-5, a second clamp valve 2-6, a third clamp valve 2-7, a fourth clamp valve 2-8, and the magnetically coupled precise liquid balance unit of Embodiment 1; the first end of the waste liquid outlet pipe 2-1 is fluidly connected to the waste liquid outlet of the blood filter 2-9, the second end of the waste liquid outlet pipe 2-1 is fluidly connected to the waste liquid outlet pipe 2-3, and the third clamp valve 2-7 is located on the waste liquid outlet pipe 2-1 and installed adjacent to the second end of the waste liquid outlet pipe 2-1; the first end of the waste liquid outlet pipe 2-3 is fluidly connected to the second fluid inlet / outlet 1-5, the second end of the waste liquid outlet pipe 2-3 is fluidly connected to the waste liquid container 2-10, and the fourth clamp valve 2-8 is adjacent to the waste liquid container 2-10 and the waste liquid outlet pipe 2-5. The waste liquid discharge pipe 2-3 is installed between the connection node of the waste liquid discharge pipe 2-3 and the external input liquid; when the external input liquid is the replacement fluid: the first end of the external input liquid inlet pipe 2-2 is fluidly connected to the blood outlet pipe 2-12 or blood inlet pipe 2-13 of the blood filter 2-9; when the external input liquid is the dialysate: the first end of the external input liquid inlet pipe 2-2 is fluidly connected to the dialysate inlet of the blood filter 2-9, and the second end of the external input liquid inlet pipe 2-2 is fluidly connected to the first fluid inlet / outlet 1-4; the second pinch valve 2-6 is installed near the external input liquid supply pipe 2-11 that is fluidly connected between the external input liquid container 2-4 and the external input liquid inlet pipe 2-2; the first pinch valve 2-5 is installed near the external input liquid inlet pipe 2-2 between the connection node of the blood outlet pipe 2-12 and the external input liquid supply pipe 2-11 and the external input liquid inlet pipe 2-2.

[0055] When the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the first clamp valve 2-5 opens, the second clamp valve 2-6 closes, the third clamp valve 2-7 opens, and the fourth clamp valve 2-8 closes. When the external input fluid is a replacement fluid: the external input fluid in the first inlet / outlet fluid receiving chamber 1-6 is discharged from the first fluid inlet / outlet 1-4 to the blood outlet pipe 2-12 to enter the human body or discharged to the blood inlet pipe 2-13 to dilute the blood about to enter the blood filter 2-9. When the external input fluid is a dialysate: the external input fluid in the first inlet / outlet fluid receiving chamber 1-6 is discharged from the first fluid inlet / outlet 1-4 to the dialysate inlet of the blood filter 2-9, while the waste fluid in the blood filter 2-9 is drawn into the second inlet / outlet fluid receiving chamber 1-7. When the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the first clamp valve 2-5 closes, the second clamp valve 2-6 opens, the third clamp valve 2-7 closes, and the fourth clamp valve 2-8 opens. External input liquid enters the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 into the waste liquid container 2-10.

[0056] From the blood filter 2-9 to the third clamp valve 2-7: a second pressure sensor 2-14 and a blood leakage sensor 2-15 are sequentially installed on the waste liquid outlet pipe 2-1; a first pressure sensor 2-16 is installed on the external input fluid inlet pipe 2-2 between the first clamp valve 2-5 and the blood outlet pipe 2-12; a liquid air detector 2-17 is installed on the external input fluid supply pipe 2-11 between the second clamp valve 2-6 and the external input fluid container 2-4.

[0057] When the external input fluid is a replacement fluid, the magnetically coupled precise liquid balance control device in this embodiment can be called a magnetically coupled replacement fluid balance device; when the external input fluid is a dialysate, the magnetically coupled precise liquid balance control device in this embodiment can be called a magnetically coupled dialysate balance device.

[0058] The specific working principle of the magnetically coupled precise liquid balance control device in this embodiment is as follows:

[0059] A-1. Blood flows from the blood inlet to the blood outlet through the blood filter under the power of an external blood pump, realizing the conventional method of extracorporeal blood circulation in the industry. This is not the main content of this invention, and the complete extracorporeal blood circulation path is not marked.

[0060] A-2. The magnetically coupled active component 1-3 (referred to as the moving magnet) moves left and right under the power of the stepper motor 1-8 and related mechanical transmission structure. That is, the stepper motor 1-8 drives the screw 1-12 to rotate, and the screw 1-12 drives the slider 1-11 to move back and forth linearly along the slide rail 1-10. When moving, the magnetically coupled driven component 1-2 (referred to as the magnetic piston) in the injection cylinder 1-1 moves left and right due to the magnetic coupling. The magnetically coupled driven component 1-2 (referred to as the magnetic piston) isolates the inside of the injection cylinder into the first fluid inlet and outlet cavity 1-6 (i.e., the left cavity) and the second fluid inlet and outlet cavity 1-7 (i.e., the right cavity).

[0061] A-3. When the magnetically coupled driven component 1-2 (referred to as the magnetic piston) moves from left to right, the second clamp valve 2-6 and the fourth clamp valve 2-8 are in the open state, and the first clamp valve 2-5 and the third clamp valve 2-7 are in the closed state. The first inlet and outlet fluid receiving chamber 1-6 (i.e., the left chamber) of the syringe 1-1 will draw the replacement fluid from the replacement fluid bag, and the second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber) of the syringe 1-1 will push the waste liquid in it into the waste liquid bag.

[0062] A-4. When the magnetically coupled driven component 1-2 (referred to as the magnetic piston) moves from right to left, the first clamp valve 2-5 and the third clamp valve 2-7 are in the open state, and the second clamp valve 2-6 and the fourth clamp valve 2-8 are in the closed state. The first inlet and outlet fluid receiving chamber 1-6 (i.e., the left chamber) of the syringe 1-1 will push the replacement fluid in it into the blood circuit to combine with the blood, and the second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber) of the syringe 1-1 will aspirate the waste liquid filtered out by the blood filter.

[0063] Note: Before treatment, the system will have a pre-filling mode to pre-fill: fill all the tubes with liquid. After the pre-filling mode is completed, the first inlet and outlet fluid receiving chamber 1-6 (i.e., the left chamber) of the syringe 1-1 will be filled with replacement fluid and the second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber) will be filled with waste liquid. Only then will the above-mentioned actions A-3 and A-4 be performed.

[0064] A-5. Throughout the process, A-3 and A-4 are executed in a cycle until the treatment stops. This ensures that the replacement fluid supplied to the blood and the waste fluid discharged from the blood are equal in volume, thus not only realizing the dynamics of fluid flow but also ensuring precise fluid balance control.

[0065] The tubing connected to the first inlet / outlet fluid receiving chamber 1-6 (i.e., the left chamber) of syringe 1-1 can also be connected to the blood tubing before the filter to achieve pre-dilution of the replacement fluid.

[0066] A-7, First pressure sensor 2-16 measures the pressure of the replacement fluid pushed into the blood circuit to ensure that the blood circuit is unobstructed.

[0067] A-8, Second pressure sensor 2-14 measures the pressure of blood extracted from waste liquid to ensure that the blood filter fiber membrane is not clogged.

[0068] A-9, the blood leakage sensor 2-15 detects whether there is hemoglobin precipitation in the extracted waste fluid to ensure that the blood filter fibers are not damaged.

[0069] A-10. The displacement fluid weighing sensor monitors the weight of the displacement fluid container in real time and is linked to the set dispensing speed of the displacement fluid. If the magnetic coupling driven part 1-2 (referred to as the magnetic piston) is not tightly sealed, and leakage occurs between the first inlet and outlet fluid receiving chamber 1-6 (i.e., the left chamber) and the second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber), the weight change of the displacement fluid will deviate from the set dispensing speed, and the abnormality can be detected in time.

[0070] A-11. When the liquid in the replacement fluid container is emptied, the liquid empty detector 2-17 will detect and sense it to ensure treatment safety.

[0071] A-12. The pinch valve is equipped with position detection feedback, which allows the system to determine the current opening and closing status of the pinch valve and prevent unexpected actions.

[0072] A-13. The pinch valve is equipped with a pipeline presence detection system to sense whether the pipeline is correctly clamped in the corresponding position.

[0073] A-14. The magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet) is provided with a limit mechanism 1-13 on the moving magnet fixing bracket 1-9. In this embodiment, a limit micro switch is used, and the system can promptly sense the deviation of the magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet) from moving left or right to the limit position.

[0074] A-15. The screw position of the magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet) of the motion mechanism is equipped with an encoder or sliding resistor to detect the position of the magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet) in real time, so as to ensure the correct movement of the magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet).

[0075] A-16. The magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet) is equipped with a magnetic coupling driven component 1-2, namely a magnetic piston decoupling detection mechanism 1-15, to ensure that the magnetic coupling driven component 1-2 (hereinafter referred to as the magnetic piston) always follows the movement of the magnetic coupling active component 1-3 (hereinafter referred to as the moving magnet).

[0076] Example 3

[0077] like Figure 2As shown, the magnetically coupled precise liquid balance control device in this embodiment includes a waste liquid outlet pipe 2-1, a waste liquid discharge pipe 2-3, a first clamp valve 2-5, a second clamp valve 2-6, and the magnetically coupled precise liquid balance unit described in Embodiment 1. The first end of the waste liquid outlet pipe 2-1 is fluidly connected to the waste liquid outlet of the blood filter 2-9, and the second end of the waste liquid outlet pipe 2-1 is fluidly connected to the waste liquid discharge pipe 2-3. The first clamp valve 2-5 is installed adjacent to the second end of the waste liquid outlet pipe 2-1. The first end of the waste liquid discharge pipe 2-3 is fluidly connected to the second fluid inlet / outlet 1-5, and the second end of the waste liquid discharge pipe 2-3 is fluidly connected to the waste liquid container 2-10. The second clamp valve 2-6 is installed adjacent to the waste liquid discharge pipe 2-3 between the waste liquid container 2-10 and the connection point between the waste liquid outlet pipe 2-1 and the waste liquid discharge pipe 2-3. The first fluid inlet / outlet 1-4 is fluidly connected to the external atmospheric fluid.

[0078] When the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the first clamp valve 2-5 opens and the second clamp valve 2-6 closes, allowing the gas in the first fluid inlet / outlet accommodating chamber 1-6 to be discharged from the first fluid inlet / outlet 1-4, while simultaneously drawing the waste liquid in the blood filter 2-9 into the second fluid inlet / outlet accommodating chamber 1-7; when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the first clamp valve 2-5 closes and the second clamp valve 2-6 opens, allowing external gas to enter the first fluid inlet / outlet accommodating chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second fluid inlet / outlet accommodating chamber 1-7 into the waste liquid container 2-10.

[0079] From the waste liquid outlet of the blood filter 2-9 to the first clamp valve 2-5, a first pressure sensor 2-16 and a blood leakage sensor 2-15 are sequentially installed on the waste liquid outlet pipe 2-1.

[0080] In this embodiment, the magnetically coupled precise fluid balance control device serves as a separate magnetically coupled dehydration unit, enabling SCUF (Slow Continuous UltraFiltration) treatment mode, allowing for continuous and slow ultrafiltration. In this mode, replacement fluid and dialysate are not required; continuous and slow blood dehydration is achieved independently.

[0081] Example 4

[0082] like Figure 3As shown, the magnetically coupled precise liquid balance control device in this embodiment includes a fifth clamp valve 2-20, a sixth clamp valve 2-21, a net dehydration discharge pipe 2-22, a magnetically coupled precise liquid balance unit as described in Embodiment 1, and a magnetically coupled precise liquid balance control device as described in Embodiment 2; the external input liquid is a replacement liquid, the magnetically coupled precise liquid balance unit in the magnetically coupled precise liquid balance control device of Embodiment 2 is a first magnetically coupled precise liquid balance unit, and the magnetically coupled precise liquid balance unit of Embodiment 1 is a second magnetically coupled precise liquid balance unit; the net The first end of the dehydration discharge pipe 2-22 is fluidly connected to the second fluid inlet / outlet 1-5 of the second magnetically coupled precision liquid balance unit, and the second end of the clean dehydration discharge pipe 2-22 is fluidly connected to the waste liquid container 2-10; the clean dehydration discharge pipe 2-22 and the waste liquid outlet pipe 2-1 are fluidly connected through a branch pipe, and the fifth clamp valve 2-20 is installed adjacent to the branch pipe; the sixth clamp valve 2-21 is installed adjacent to the waste liquid container 2-10 and the clean dehydration discharge pipe 2-22 at the connection node between the clean dehydration discharge pipe 2-22 and the branch pipe.

[0083] In the first magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component 1-2 moves towards the direction adjacent to the first fluid inlet / outlet 1-4, the first clamp valve 2-5 opens, the second clamp valve 2-6 closes, the third clamp valve 2-7 opens, and the fourth clamp valve 2-8 closes. This allows the replacement fluid in the first inlet / outlet fluid receiving chamber 1-6 to be discharged from the first fluid inlet / outlet 1-4 into the blood outlet pipe 2-12 to enter the human body, or discharged into the blood inlet pipe 2-13 to enter the blood filter 2-9, achieving pre-dilution of the replacement fluid. When the waste liquid in the blood filter 2-9 is drawn into the second inlet / outlet fluid receiving chamber 1-7, when the magnetic coupling driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the first clamp valve 2-5 closes, the second clamp valve 2-6 opens, the third clamp valve 2-7 closes, and the fourth clamp valve 2-8 opens, the replacement fluid enters the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, and at the same time, the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 is discharged into the waste liquid container 2-10.

[0084] In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the fifth clamp valve 2-20 opens and the sixth clamp valve 2-21 closes, discharging the gas in the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously drawing the waste liquid in the blood filter 2-9 into the second inlet / outlet fluid receiving chamber 1-7; when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the fifth clamp valve 2-20 closes and the sixth clamp valve 2-21 opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 into the waste liquid container 2-10.

[0085] This embodiment utilizes a combination of a magnetically coupled replacement fluid balancing device and a magnetically coupled dehydration unit to achieve CVVH treatment mode (CVVH, Continuous Venous-Venous Hemofiltration), a continuous venous-venous blood filtration process.

[0086] B-1. Based on the movements of A-1 to A-4 in Example 2, when the magnetic coupling driven part 1-2 (referred to as magnetic piston) of the syringe 1-1 moves from right to left, the fifth clamp valve 2-20 is in the open state and the sixth clamp valve 2-21 is in the closed state. The second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber) of the syringe 1-1 will draw up the waste liquid filtered by the blood filter.

[0087] B-2. When the magnetically coupled driven part 1-2 (referred to as magnetic piston) of the syringe 1-1 moves from left to right, the sixth clamp valve 2-21 is in the open state and the fifth clamp valve 2-20 is in the closed state. The second inlet and outlet fluid receiving chamber 1-7 (i.e. the right chamber) of the syringe 1-1 will push the waste liquid in it into the waste liquid container.

[0088] In this way, based on fluid balance, net dehydration is controlled, thereby achieving CVVH treatment.

[0089] Example 5

[0090] like Figure 4As shown, the magnetically coupled precise liquid balance control device in this embodiment includes a fifth clamp valve 2-20, a sixth clamp valve 2-21, a net dehydration discharge pipe 2-22, a magnetically coupled precise liquid balance unit as described in Embodiment 1, and a magnetically coupled precise liquid balance control device as described in Embodiment 2; the external input liquid is dialysis fluid, the magnetically coupled precise liquid balance unit in the magnetically coupled precise liquid balance control device of Embodiment 2 is the first magnetically coupled precise liquid balance unit, and the magnetically coupled precise liquid balance unit of Embodiment 1 is the second magnetically coupled precise liquid balance unit; the net dehydration... The first end of the water discharge pipe 2-22 is fluidly connected to the second fluid inlet / outlet 1-5 of the second magnetically coupled precision liquid balance unit, and the second end of the clean dehydration discharge pipe 2-22 is fluidly connected to the waste liquid container 2-10; the clean dehydration discharge pipe 2-22 and the waste liquid outlet pipe 2-1 are fluidly connected through a branch pipe, and the fifth pinch valve 2-20 is installed adjacent to the branch pipe; the sixth pinch valve 2-21 is installed adjacent to the clean dehydration discharge pipe 2-22 between the waste liquid container 2-10 and the clean dehydration discharge pipe 2-22 and the branch pipe connection node;

[0091] In the first magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves towards the direction adjacent to the first fluid inlet / outlet 1-4, the first clamp valve 2-5 opens, the second clamp valve 2-6 closes, the third clamp valve 2-7 opens, and the fourth clamp valve 2-8 closes. This allows the dialysate in the first fluid inlet / outlet chamber 1-6 to be discharged from the first fluid inlet / outlet 1-4 through the dialysate inlet into the blood filter 2-9, where it undergoes solute exchange with the blood in the hollow fiber membrane. Simultaneously, the blood filter 2-9 also receives the solute that has already undergone solute exchange. The dialysate, considered as waste liquid, is drawn from the dialysate outlet into the second inlet / outlet fluid receiving chamber 1-7. When the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the first clamp valve 2-5 closes, the second clamp valve 2-6 opens, the third clamp valve 2-7 closes, and the fourth clamp valve 2-8 opens. The dialysate enters the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 into the waste liquid container 2-10.

[0092] In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the fifth clamp valve 2-20 opens and the sixth clamp valve 2-21 closes, discharging the gas in the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously drawing the waste liquid in the blood filter 2-9 into the second inlet / outlet fluid receiving chamber 1-7; when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the fifth clamp valve 2-20 closes and the sixth clamp valve 2-21 opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 into the waste liquid container 2-10.

[0093] This embodiment utilizes a combination of a magnetically coupled dialysate balancing device and a magnetically coupled dehydration unit to achieve CVVHD treatment mode (CVVH, Continuous Venous-Venous HemoDialysis), a continuous venous-venous hemodialysis.

[0094] C-1. When the magnetic piston inside syringe 1-1 moves from left to right, the eighth clamp valve 2-24 and the tenth clamp valve 2-26 are in the open state, and the seventh clamp valve 2-23 and the ninth clamp valve 2-25 are in the closed state. The left chamber of the syringe will draw dialysate from the dialysate bag, and the right chamber of the syringe will push the waste liquid in it into the waste liquid bag.

[0095] C-2. When the magnetically coupled driven component 1-2 (referred to as the magnetic piston) in the syringe 1-1 moves from right to left, the seventh clamp valve 2-23 and the ninth clamp valve 2-25 are in the open state, and the eighth clamp valve 2-24 and the tenth clamp valve 2-26 are in the closed state. The first inlet and outlet fluid receiving chamber 1-6 (i.e., the left chamber) of the syringe 1-1 will push the dialysate in it into the dialysate inlet of the blood filter to exchange solutes with the blood in the hollow fiber membrane. The second inlet and outlet fluid receiving chamber 1-7 (i.e., the right chamber) of the syringe 1-1 will aspirate the dialysate that has undergone solute exchange and regard it as waste liquid.

[0096] C-3. Following the working principles described in B-1 to B-2, the magnetically coupled dehydration unit achieves dehydration control. This, in turn, realizes the CVVH treatment mode.

[0097] C-4. The functions of the dialysate-related liquid air detector, dialysate weighing sensor, and pressure sensor are equivalent to the corresponding components in Example 4.

[0098] Example 6

[0099] like Figure 5As shown, the magnetically coupled precise liquid balance control device in this embodiment includes a fifth clamp valve 2-20, a sixth clamp valve 2-21, a clean dehydration discharge pipe 2-22, one magnetically coupled precise liquid balance unit as described in Embodiment 1, and two magnetically coupled precise liquid balance control devices as described in Embodiment 2. The two magnetically coupled precise liquid balance control devices share a single waste liquid discharge pipe 2-1. The external input liquid in the first magnetically coupled precise liquid balance control device is a replacement fluid, and the magnetically coupled precise liquid balance unit therein is a first magnetically coupled precise liquid balance unit. The external input liquid in the second magnetically coupled precise liquid balance control device is dialysis fluid, and the magnetically coupled precise liquid balance unit therein is a second magnetically coupled precise liquid balance unit. The first clamp valve 2-5 and the second clamp valve 2-6 in the second magnetically coupled precise liquid balance control device... The third clamp valve 2-7 and the fourth clamp valve 2-8 are sequentially named the seventh clamp valve 2-23, the eighth clamp valve 2-24, the ninth clamp valve 2-25, and the tenth clamp valve 2-26. In Example 1, the magnetically coupled precise liquid balance unit is the third magnetically coupled precise liquid balance unit. The first end of the net dehydration discharge pipe 2-22 is fluidly connected to the second fluid inlet / outlet 1-5 of the third magnetically coupled precise liquid balance unit, and the second end of the net dehydration discharge pipe 2-22 is fluidly connected to the waste liquid container 2-10. The net dehydration discharge pipe 2-22 and the waste liquid outlet pipe 2-1 are fluidly connected through a branch pipe, and the fifth clamp valve 2-20 is installed adjacent to the branch pipe. The sixth clamp valve 2-21 is installed adjacent to the waste liquid container 2-10 and the net dehydration discharge pipe 2-22 at the connection point between the net dehydration discharge pipe 2-22 and the branch pipe.

[0100] In the first magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the first clamp valve 2-5 opens, the second clamp valve 2-6 closes, the third clamp valve 2-7 opens, and the fourth clamp valve 2-8 closes, allowing the replacement fluid in the first inlet / outlet fluid receiving chamber 1-6 to be discharged from the first fluid inlet / outlet 1-4 into the blood outlet pipe 2-12 and enter the human body. At the same time, the waste liquid in the blood filter 2-9 is drawn into the second inlet / outlet fluid receiving chamber 1-7. When the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the first clamp valve 2-5 closes, the second clamp valve 2-6 opens, the third clamp valve 2-7 closes, and the fourth clamp valve 2-8 opens, allowing the replacement fluid to enter the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4. At the same time, the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 is discharged into the waste liquid container 2-10.

[0101] In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the seventh clamp valve 2-23 opens, the eighth clamp valve 2-24 closes, the ninth clamp valve 2-25 opens, and the tenth clamp valve 2-26 closes. This allows the dialysate in the first inlet / outlet fluid receiving chamber 1-6 to be discharged from the first fluid inlet / outlet 1-4 through the dialysate inlet into the blood filter 2-9, where it exchanges solutes with the blood in the hollow fiber membrane. Simultaneously, the solutes already exchanged in the blood filter 2-9 are removed. The exchanged dialysate is considered waste liquid and pumped into the second inlet / outlet fluid receiving chamber 1-7; when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the seventh clamp valve 2-23 closes, the eighth clamp valve 2-24 opens, the ninth clamp valve 2-25 closes, and the tenth clamp valve 2-26 opens, and the dialysate enters the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 is discharged into the waste liquid container 2-10;

[0102] In the third magnetically coupled precision liquid balance unit: when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the first fluid inlet / outlet 1-4, the fifth clamp valve 2-20 opens and the sixth clamp valve 2-21 closes, discharging the gas in the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously drawing the waste liquid in the blood filter 2-9 into the second inlet / outlet fluid receiving chamber 1-7; when the magnetically coupled driven component 1-2 moves toward the direction adjacent to the second fluid inlet / outlet 1-5, the fifth clamp valve 2-20 closes and the sixth clamp valve 2-21 opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber 1-6 from the first fluid inlet / outlet 1-4, while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber 1-7 into the waste liquid container 2-10.

[0103] This embodiment combines three devices: a magnetically coupled replacement fluid balancing device, a magnetically coupled dialysate balancing device, and a magnetically coupled dehydration unit, to achieve CVVHDF (Continuous Venous-Venous HemoDiaFiltration) treatment mode. In this mode, all three units operate simultaneously, performing hemofiltration, hemodialysis, and dehydration control concurrently.

[0104] The magnetically coupled replacement fluid balancing unit achieves a balance between replacement fluid infusion and blood waste discharge;

[0105] The magnetically coupled dialysate balance unit achieves a balance between dialysate inflow and dialysate waste discharge;

[0106] The magnetically coupled dehydration unit enables control over the amount of water removed.

[0107] In the above embodiments, it should be noted that in practical applications, the syringe and its internal magnetic piston, bag, tubing, filter, etc. are all disposable consumables.

[0108] It should be noted that all pinch valves in this application can be one-way valves. Although it is simpler to use one-way valves, they are less reliable, prone to leakage over time, and cannot be automatically identified or detected when leaking. Furthermore, due to the pressure tolerance of one-way valves, they may open when not needed. Pipeline fittings are disposable, and using one-way valves will increase costs and make it difficult to meet biocompatibility requirements.

[0109] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A magnetically coupled precision liquid balance unit, characterized in that, The device includes an injection cylinder (1-1), a magnetically coupled driven component (1-2), and a magnetically coupled active component (1-3). The injection cylinder (1-1) has a first fluid inlet / outlet (1-4) at its first end and a second fluid inlet / outlet (1-5) at its second end. The magnetically coupled driven component (1-2) is located inside the injection cylinder (1-1) and divides the cavity of the injection cylinder (1-1) into a first fluid inlet / outlet cavity (1-6) and a second fluid inlet / outlet cavity (1-7). The contact surface between the magnetically coupled driven component (1-2) and the inner wall of the injection cylinder (1-1) is fluid-sealed. The magnetically coupled active component (1-3) is located outside the injection cylinder (1-1), and the magnetically coupled active component (1-3) is connected to the magnetically coupled... The driven component (1-2) interacts magnetically, and when the magnetically coupled active component (1-3) moves, it drives the magnetically coupled driven component (1-2) to reciprocate within the syringe (1-1) via magnetic force. When the magnetically coupled driven component (1-2) pushes out the fluid in the first fluid inlet / outlet cavity (1-6) through the first fluid inlet / outlet (1-4), the second fluid inlet / outlet cavity (1-7) draws in fluid through the second fluid inlet / outlet (1-5). When the magnetically coupled driven component (1-2) pushes out the second fluid inlet / outlet cavity (1-7) through the second fluid inlet / outlet (1-5), the first fluid inlet / outlet cavity (1-6) draws in liquid through the first fluid inlet / outlet (1-4). The magnetically coupled driven component (1-2) is an electrical pure iron, ferrite, or permanent magnet, and the magnetically coupled active component (1-3) is an electromagnet or rare earth permanent magnet; the magnetically coupled active component (1-3) and the magnetically coupled driven component (2) attract each other to form a magnetic coupling force; when the magnetically coupled driven component (2) reciprocates in the injection cylinder (1-1): the resistance overcome when the first fluid inlet / outlet cavity (1-6) pushes out fluid through the first fluid inlet / outlet (1-4) or when the second fluid inlet / outlet cavity (1-7) pushes out fluid through the second fluid inlet / outlet (1-5) is greater than or equal to 450 mmHg, and the resistance overcome when the second fluid inlet / outlet cavity (1-7) draws in fluid through the second fluid inlet / outlet (1-5) or when the first fluid inlet / outlet cavity (1-6) draws in fluid through the first fluid inlet / outlet (1-4) is less than or equal to -450 mmHg.

2. The magnetically coupled precision liquid balance unit according to claim 1, characterized in that, The cross-section of the receiving cavity of the injection cylinder (1-1) is a rounded rectangle or a circle.

3. The magnetically coupled precision liquid balance unit according to claim 1, characterized in that, A sealing ring is installed on the surface of the magnetically coupled driven component (1-2) that contacts the inner wall of the injection cylinder (1-1); the cylinder wall of the injection cylinder (1-1) is wholly or partially transparent or semi-transparent, and the inner wall of the injection cylinder (1-1) has a hydrophilic coating.

4. The magnetically coupled precision liquid balance unit according to claim 1, characterized in that, It also includes a stepper motor (1-8), a bracket (1-9), a slide rail (1-10), a slider (1-11), a screw (1-12), a limiting mechanism (1-13), a stroke detection mechanism (1-14), and a decoupling detection mechanism (1-15). The slide rail (1-10) is mounted on the bracket (1-9), the slider (1-11) is located on the slide rail (1-10), and the screw (1-12) passes through a threaded hole on the slider (1-11). The stepper motor (1-8) drives the screw (1-12) to rotate in both directions. 12) Drive the slider (1-11) to reciprocate linearly along the slide rail (1-10); there are two limiting mechanisms (1-13) located at the end of the forward stroke and the end of the reverse stroke of the slider (1-11) respectively; the stroke detection mechanism (1-14) determines the stroke distance of the slider (1-11) by the number of rotations of the screw (1-12); the magnetic coupling active component (1-3) is installed on the slider (1-11); the decoupling detection mechanism (1-15) is installed on the slider (1-11) adjacent to the magnetic coupling active component (1-3).

5. The magnetically coupled precision liquid balance unit according to claim 4, characterized in that, The bracket (1-9) includes a left upright plate (1-16), a right upright plate (1-17), and a base plate (1-18). The left upright plate (1-16) and the right upright plate (1-17) are respectively fixedly installed on two opposite side edges of the base plate (1-18). The two ends of the screw (1-12) are respectively installed on bearings on the left upright plate (1-16) and the right upright plate (1-17). The stepper motor (1-8) is fixedly installed on the left upright plate (1-16). The slide rail (1-10) is installed on the base plate (1-18) and located between the left upright plate (1-16) and the right upright plate (1-18). Between 17), the two limiting mechanisms (1-13) are respectively installed on the left upright plate (1-16) and the right upright plate (1-17). The top of the slider (1-11) has an upward-opening U-shaped coupling seat (1-19). The magnetic coupling active component (1-3) and the decoupling detection mechanism (1-15) are both installed on the U-shaped coupling seat (1-19). The two ends of the injection cylinder (1-1) are respectively installed on the left upright plate (1-16) and the right upright plate (1-17), and a part of the injection cylinder (1-1) is located in the U-shaped space of the U-shaped coupling seat (1-19).

6. A magnetically coupled precision liquid balance control device, characterized in that, The system includes a waste liquid outlet pipe (2-1), an external input liquid inlet pipe (2-2), a waste liquid outlet pipe (2-3), an external input liquid container (2-4), a first clamp valve (2-5), a second clamp valve (2-6), a third clamp valve (2-7), a fourth clamp valve (2-8), and a magnetically coupled precision liquid balance unit as described in any one of claims 1-5; the first end of the waste liquid outlet pipe (2-1) is fluidly connected to the waste liquid outlet of the blood filter (2-9), and the second end of the waste liquid outlet pipe (2-1) is connected to the... The waste liquid discharge pipe (2-3) is fluid-conducting. The third clamp valve (2-7) is located on the waste liquid outlet pipe (2-1) and installed adjacent to the second end of the waste liquid outlet pipe (2-1). The first end of the waste liquid discharge pipe (2-3) is fluid-conducting with the second fluid inlet / outlet (1-5), and the second end of the waste liquid discharge pipe (2-3) is fluid-conducting with the waste liquid container (2-10). The fourth clamp valve (2-8) is located adjacent to the waste liquid container (2-10) and the waste liquid outlet pipe (2-1) and the... The waste liquid discharge pipe (2-3) is installed between the connecting nodes; when the external input fluid is a replacement fluid: the first end of the external input fluid inlet pipe (2-2) is fluidly connected to the blood outlet pipe (2-12) or blood inlet pipe (2-13) of the blood filter (2-9); when the external input fluid is a dialysate: the first end of the external input fluid inlet pipe (2-2) is fluidly connected to the dialysate inlet of the blood filter (2-9); the second end of the external input fluid inlet pipe (2-2) is fluidly connected to the dialysate inlet of the blood filter (2-9). The end is fluidly connected to the first fluid inlet / outlet (1-4), the second clamp valve (2-6) is installed adjacent to the external input fluid supply pipe (2-11) that is fluidly connected between the external input fluid container (2-4) and the external input fluid inlet pipe (2-2), and the first clamp valve (2-5) is installed adjacent to the external input fluid inlet pipe (2-2) between the blood outlet pipe (2-12) and the external input fluid supply pipe (2-11) and the external input fluid inlet pipe (2-2) at the connection node; When the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the first clamp valve (2-5) opens, the second clamp valve (2-6) closes, the third clamp valve (2-7) opens, and the fourth clamp valve (2-8) closes. When the external input fluid is a replacement fluid: the external input fluid in the first fluid inlet / outlet chamber (1-6) is discharged from the first fluid inlet / outlet chamber (1-4) to the blood outlet pipe (2-12) to enter the human body or discharged to the blood inlet pipe (2-13) to dilute the blood about to enter the blood filter (2-9). When the external input fluid is a dialysis ... A fluid inlet / outlet (1-4) discharges into the dialysate inlet of the blood filter (2-9), while simultaneously drawing waste fluid from the blood filter (2-9) into the second inlet / outlet fluid receiving chamber (1-7). When the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the first clamp valve (2-5) closes, the second clamp valve (2-6) opens, the third clamp valve (2-7) closes, and the fourth clamp valve (2-8) opens. External input fluid enters the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging waste fluid from the second inlet / outlet fluid receiving chamber (1-7) into the waste fluid container (2-10).

7. The magnetically coupled precise liquid balance control device according to claim 6, characterized in that, From the blood filter (2-9) to the third clamp valve (2-7): a second pressure sensor (2-14) and a blood leakage sensor (2-15) are installed sequentially on the waste liquid outlet pipe (2-1); a first pressure sensor (2-16) is installed on the external input liquid inlet pipe (2-2) between the first clamp valve (2-5) and the blood outlet pipe (2-12); a liquid air detector (2-17) is installed on the external input liquid supply pipe (2-11) between the second clamp valve (2-6) and the external input liquid container (2-4).

8. A magnetically coupled precision liquid balance control device, characterized in that, The device includes a waste liquid outlet pipe (2-1), a waste liquid discharge pipe (2-3), a first clamp valve (2-5), a second clamp valve (2-6), and a magnetically coupled precision liquid balance unit as described in any one of claims 1-5; the first end of the waste liquid outlet pipe (2-1) is fluidly connected to the waste liquid outlet of the blood filter (2-9), the second end of the waste liquid outlet pipe (2-1) is fluidly connected to the waste liquid discharge pipe (2-3), and the first clamp valve (2-5) is adjacent to the second end of the waste liquid outlet pipe (2-1). The waste liquid discharge pipe (2-3) is installed at one end, with the first end connected to the second fluid inlet / outlet (1-5) and the second end connected to the waste liquid container (2-10). The second clamp valve (2-6) is installed near the waste liquid container (2-10) between the waste liquid discharge pipe (2-3) and the waste liquid outlet pipe (2-1) and the waste liquid discharge pipe (2-3). The first fluid inlet / outlet (1-4) is connected to the external atmospheric fluid. When the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the first clamp valve (2-5) opens and the second clamp valve (2-6) closes, allowing the gas in the first fluid inlet / outlet accommodating chamber (1-6) to be discharged from the first fluid inlet / outlet (1-4), while simultaneously drawing the waste liquid in the blood filter (2-9) into the second fluid inlet / outlet accommodating chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the first clamp valve (2-5) closes and the second clamp valve (2-6) opens, allowing external gas to enter the first fluid inlet / outlet accommodating chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste liquid in the second fluid inlet / outlet accommodating chamber (1-7) into the waste liquid container (2-10).

9. The magnetically coupled precise liquid balance control device according to claim 8, characterized in that, From the waste liquid outlet of the blood filter (2-9) to the first clamp valve (2-5), a first pressure sensor (2-16) and a blood leakage sensor (2-15) are sequentially installed on the waste liquid outlet pipe (2-1).

10. A magnetically coupled precision liquid balance control device, characterized in that, Includes a fifth clamp valve (2-20), a sixth clamp valve (2-21), a net dehydration discharge pipe (2-22), a magnetically coupled precise liquid balance unit as described in any of claims 1-5, and a magnetically coupled precise liquid balance control device as described in any of claims 6-7; the external input liquid is a displacement fluid, the magnetically coupled precise liquid balance unit in the magnetically coupled precise liquid balance control device as described in any of claims 6-7 is a first magnetically coupled precise liquid balance unit, and the magnetically coupled precise liquid balance unit as described in any of claims 1-5 is a second magnetically coupled precise liquid balance unit; the net dehydration discharge pipe (2-22) The first end of the first end of the first end of the second end of the second end of the second end of the magnetically coupled precision liquid balance unit is in fluid communication with the second end of the second end of the net dehydration discharge pipe (2-22), and the second end of the second end of the net dehydration discharge pipe (2-22) is in fluid communication with the waste liquid container (2-10); the net dehydration discharge pipe (2-22) and the waste liquid outlet pipe (2-1) are in fluid communication through a branch pipe, and the fifth clamp valve (2-20) is installed adjacent to the branch pipe; the sixth clamp valve (2-21) is installed adjacent to the waste liquid container (2-10) and the net dehydration discharge pipe (2-22) and the branch pipe connection node of the net dehydration discharge pipe (2-22); In the first magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component (1-2) moves toward the first fluid inlet / outlet (1-4), the first clamp valve (2-5) opens, the second clamp valve (2-6) closes, the third clamp valve (2-7) opens, and the fourth clamp valve (2-8) closes. This allows the replacement fluid in the first fluid inlet / outlet chamber (1-6) to be discharged from the first fluid inlet / outlet (1-4) into the blood outlet pipe (2-12) to enter the human body, or discharged into the blood inlet pipe (2-13) to enter the blood filter (2-9), achieving pre-dilution of the replacement fluid. Waste fluid from the blood filter (2-9) is drawn into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the first clamp valve (2-5) closes, the second clamp valve (2-6) opens, the third clamp valve (2-7) closes, and the fourth clamp valve (2-8) opens, and the replacement fluid enters the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste fluid in the second inlet / outlet fluid receiving chamber (1-7) into the waste fluid container (2-10); In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the fifth clamp valve (2-20) opens and the sixth clamp valve (2-21) closes, discharging the gas in the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously drawing the waste liquid in the blood filter (2-9) into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the fifth clamp valve (2-20) closes and the sixth clamp valve (2-21) opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) into the waste liquid container (2-10).

11. A magnetically coupled precision liquid balance control device, characterized in that, The device includes a fifth clamp valve (2-20), a sixth clamp valve (2-21), a net dehydration discharge pipe (2-22), a magnetically coupled precise liquid balance unit as described in any one of claims 1-5, and a magnetically coupled precise liquid balance control device as described in any one of claims 6-7; the external input liquid is dialysate; the magnetically coupled precise liquid balance unit in the magnetically coupled precise liquid balance control device as described in any one of claims 6-7 is a first magnetically coupled precise liquid balance unit, and the magnetically coupled precise liquid balance unit as described in any one of claims 1-5 is a second magnetically coupled precise liquid balance unit; the net dehydration discharge pipe (2-22) The first end of the pipe is fluidly connected to the second fluid inlet / outlet (1-5) of the second magnetically coupled precision liquid balance unit, and the second end of the net dehydration discharge pipe (2-22) is fluidly connected to the waste liquid container (2-10); the net dehydration discharge pipe (2-22) and the waste liquid outlet pipe (2-1) are fluidly connected through a branch pipe, and the fifth pinch valve (2-20) is installed adjacent to the branch pipe; the sixth pinch valve (2-21) is installed adjacent to the net dehydration discharge pipe (2-22) between the waste liquid container (2-10) and the net dehydration discharge pipe (2-22) and the branch pipe connection node; In the first magnetically coupled precision liquid balance unit: when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the first clamp valve (2-5) opens, the second clamp valve (2-6) closes, the third clamp valve (2-7) opens, and the fourth clamp valve (2-8) closes. This allows the dialysate in the first fluid inlet / outlet chamber (1-6) to be discharged from the first fluid inlet / outlet (1-4) through the dialysate inlet into the blood filter (2-9) to exchange solutes with the blood in the hollow fiber membrane. Simultaneously, the dialysate in the blood filter (2-9) that has already undergone solute exchange is discharged... The dialysate, considered waste liquid, is drawn from the dialysate outlet into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the first clamp valve (2-5) closes, the second clamp valve (2-6) opens, the third clamp valve (2-7) closes, and the fourth clamp valve (2-8) opens, allowing the dialysate to enter the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) into the waste liquid container (2-10); In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the fifth clamp valve (2-20) opens and the sixth clamp valve (2-21) closes, discharging the gas in the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously drawing the waste liquid in the blood filter (2-9) into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the fifth clamp valve (2-20) closes and the sixth clamp valve (2-21) opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) into the waste liquid container (2-10).

12. A magnetically coupled precision liquid balance control device, characterized in that, The device includes a fifth clamp valve (2-20), a sixth clamp valve (2-21), a net dehydration discharge pipe (2-22), a magnetically coupled precise liquid balance unit as described in any one of claims 1-5, and two magnetically coupled precise liquid balance control devices as described in any one of claims 6-7; the two magnetically coupled precise liquid balance control devices share a single waste liquid discharge pipe (2-1); the external input liquid in the first magnetically coupled precise liquid balance control device is a replacement fluid and the magnetically coupled precise liquid balance unit therein is a first magnetically coupled precise liquid balance unit; the external input liquid in the second magnetically coupled precise liquid balance control device is a dialysis fluid and the magnetically coupled precise liquid balance unit therein is a second magnetically coupled precise liquid balance unit; the second magnetically coupled precise liquid balance control device includes a first clamp valve (2-5), a second clamp valve (2-6), a third clamp valve (2-7), and a fourth clamp valve (2-8). The valves are named sequentially as the seventh clamp valve (2-23), the eighth clamp valve (2-24), the ninth clamp valve (2-25), and the tenth clamp valve (2-26). The magnetically coupled precise liquid balance unit described in any one of claims 1-5 is the third magnetically coupled precise liquid balance unit. The first end of the net dehydration discharge pipe (2-22) is fluidly connected to the second fluid inlet / outlet (1-5) of the third magnetically coupled precise liquid balance unit, and the second end of the net dehydration discharge pipe (2-22) is fluidly connected to the waste liquid container (2-10). The net dehydration discharge pipe (2-22) and the waste liquid outlet pipe (2-1) are fluidly connected through a branch pipe, and the fifth clamp valve (2-20) is installed adjacent to the branch pipe. The sixth clamp valve (2-21) is installed adjacent to the waste liquid container (2-10) and the net dehydration discharge pipe (2-22) at the connection node between the net dehydration discharge pipe (2-22) and the branch pipe. In the first magnetically coupled precision liquid balancing unit: when the magnetically coupled driven component (1-2) moves toward the first fluid inlet / outlet (1-4), the first clamp valve (2-5) opens, the second clamp valve (2-6) closes, the third clamp valve (2-7) opens, and the fourth clamp valve (2-8) closes, displacing fluid in the first inlet / outlet fluid receiving chamber (1-6) is discharged from the first fluid inlet / outlet (1-4) into the blood outlet pipe (2-12) and enters the human body. Simultaneously, waste fluid from the blood filter (2-9) is drawn into the... The second inlet / outlet fluid receiving chamber (1-7) is filled with fluid. When the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the first clamp valve (2-5) is closed, the second clamp valve (2-6) is opened, the third clamp valve (2-7) is closed, and the fourth clamp valve (2-8) is opened. The replacement fluid enters the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) is discharged into the waste liquid container (2-10). In the second magnetically coupled precision liquid balance unit: when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the seventh clamp valve (2-23) opens, the eighth clamp valve (2-24) closes, the ninth clamp valve (2-25) opens, and the tenth clamp valve (2-26) closes. This allows the dialysate in the first inlet / outlet fluid receiving chamber (1-6) to be discharged from the first fluid inlet / outlet (1-4) through the dialysate inlet into the blood filter (2-9) to exchange solutes with the blood in the hollow fiber membrane. Simultaneously, the solutes already exchanged within the blood filter (2-9) are also exchanged. The replaced dialysate is considered waste liquid and pumped into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves in the direction adjacent to the second fluid inlet / outlet (1-5), the seventh clamp valve (2-23) closes, the eighth clamp valve (2-24) opens, the ninth clamp valve (2-25) closes, and the tenth clamp valve (2-26) opens, and the dialysate enters the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) is discharged into the waste liquid container (2-10); In the third magnetically coupled precision liquid balance unit: when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the first fluid inlet / outlet (1-4), the fifth clamp valve (2-20) opens and the sixth clamp valve (2-21) closes, discharging the gas in the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously drawing the waste liquid in the blood filter (2-9) into the second inlet / outlet fluid receiving chamber (1-7); when the magnetically coupled driven component (1-2) moves toward the direction adjacent to the second fluid inlet / outlet (1-5), the fifth clamp valve (2-20) closes and the sixth clamp valve (2-21) opens, allowing external gas to enter the first inlet / outlet fluid receiving chamber (1-6) from the first fluid inlet / outlet (1-4), while simultaneously discharging the waste liquid in the second inlet / outlet fluid receiving chamber (1-7) into the waste liquid container (2-10).

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