Piezoelectric porous scaffold with high efficiency osteogenesis promoting effect and preparation method thereof

By preparing a piezoelectric porous scaffold with a three-dimensional interconnected pore structure and combining it with bioactive factors, the problem of rapid and high-quality repair of large bone defects was solved. The synergistic effect of electrical signals and bioactive factors was realized, which promoted the bone repair effect.

CN117731830BActive Publication Date: 2026-08-25EAST CHINA UNIV OF SCI & TECH
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Patent Information

Application Number
CN202211117805.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-14
Publication Date
2026-08-25
Estimated Expiration
2042-09-14

AI Technical Summary

Technical Problem

Existing technologies struggle to effectively combine piezoelectric effects with bioactive factors to achieve rapid and high-quality repair of large bone defects, and electrical stimulation devices present implantation difficulties and potential risks.

Method used

A piezoelectric porous scaffold was prepared using the polyurethane sponge method. By combining biological components and piezoelectric components, and through binder mixing, sintering and polarization treatment, bioactive factors such as VEGF, BMP-2 and TGF-β1 were loaded to form a scaffold with a three-dimensional interconnected pore structure, thereby realizing the synergistic effect of electrical signals and bioactive factors.

Benefits of technology

It enables rapid and efficient repair of large bone defects using piezoelectric porous scaffolds, reduces the amount of bioactive factors used, avoids the side effects of overuse, promotes early cellular behavioral responses and osteogenic differentiation, and improves bone repair efficacy.

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Abstract

The application discloses a piezoelectric porous scaffold with high efficient osteogenesis and a preparation method thereof. The piezoelectric porous scaffold is obtained by mixing a biological component and a piezoelectric component through an adhesive, sintering and then performing polarization treatment. The piezoelectric porous scaffold can efficiently load and adsorb bioactive protein factors, realizes effective release of the protein, and has piezoelectric performance and osteogenesis activity. Under the multiple effects of the piezoelectric effect, the porous structure and the bioactivity of the protein of the scaffold, the piezoelectric porous scaffold can quickly start early response of bone marrow stromal cells in a synergistic manner, and then promote cell adhesion, proliferation and osteogenic differentiation. The piezoelectric porous scaffold has important significance for efficient and rapid repair of large bone defects, bone nonunion and other bone defects.
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