枸杞多糖在抑制P.azotoformans中的应用

By using a drug for treating intestinal damage made from Lycium barbarum polysaccharides, the abundance of P. azotoformans was inhibited, thus resolving intestinal damage caused by immunodeficiency, improving gut microbiota and tissue structure, and enhancing intestinal function.

CN117756955BActive Publication Date: 2026-07-17NORTHWEST UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHWEST UNIV
Filing Date
2023-12-07
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies have failed to effectively address intestinal damage caused by immunodeficiency, particularly the problems of intestinal flora imbalance and tissue damage caused by Pseudomonas azotoformans.

Method used

Using Lycium barbarum polysaccharides, different components of Lycium barbarum polysaccharide aqueous solutions are prepared, and pharmaceutically acceptable excipients are added to make capsules, tablets, granules, injections, sustained-release preparations, oral liquids or drop pills, which are used to inhibit the increase of P. azotoformans abundance in the intestine and improve intestinal flora imbalance.

Benefits of technology

Lycium barbarum polysaccharides can significantly reduce the abundance of P. azotoformans in the intestines of immunodeficient mice, improve jejunal tissue morphology, enrich short-chain fatty acids, improve immune organ index and body weight, and alleviate intestinal damage caused by immunodeficiency.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明涉及生物医药技术领域,具体提供枸杞多糖在抑制P.azotoformans中的应用。本发明提供了枸杞多糖通过抑制小鼠肠道中P.azotoformans菌的丰度,从而缓解免疫缺陷引起的肠道损伤。具体地,免疫缺陷小鼠摄入所述枸杞多糖后,肠道中P.azotoformans的相对丰度降低,空肠组织形态获得改善、肠道中短链脂肪酸得到富集以及血清代谢物发生改变,证实枸杞多糖能够通过抑制P.azotoformans菌的丰度来缓解免疫缺陷引起的肠道损伤。
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