A skin soothing and repairing composition, its preparation method and application

Abstract

This invention belongs to the field of cosmetic technology, specifically relating to a skin soothing and repairing composition, its preparation method, and its application. The skin soothing and repairing composition of this invention comprises the following components: oligopeptide-215, sodium DNA, ceramide NP, and cetyl-PG hydroxyethyl palmitamide. In this skin soothing and repairing composition, oligopeptide-215 and sodium DNA are selected as endogenous soothing and repairing components, while ceramide NP and cetyl-PG hydroxyethyl palmitamide are selected as exogenous supplementary lipid components. Through the combination of endogenous soothing and repairing and exogenous supplementary lipids, the problem is addressed bidirectionally through two pathways from the inside out, fundamentally resolving skin problems.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a skin soothing and repairing composition, its preparation method, and its application. Background Technology

[0002] As more and more people overdo skincare, problems such as facial redness, damaged skin barrier, and dehydration frequently occur, leading to a particularly strong demand for skincare products with soothing and repairing effects.

[0003] Chinese invention patent CN114748396A discloses a soothing and moisturizing composition suitable for dry skin, its preparation method and application. The soothing and moisturizing composition includes the following raw materials in weight percentage: ceramide III 0.1-0.5%, cetyl PG hydroxyethyl palmitamide 1-7%, Scutellaria baicalensis extract 0.5-3%, and β-glucan 0.02-0.7%. The soothing and moisturizing composition provided by this invention is used to prepare a soothing and moisturizing cream with good soothing, moisturizing and repairing effects.

[0004] Another Chinese invention patent, CN111481456A, discloses a soothing composition made from the following components in parts by weight: 1020 parts sandalwood extract; 1020 parts Atractylodes macrocephala rhizome extract; 1020 parts kava pepper extract; 1020 parts silver thread grass extract; 1020 parts Saposhnikovia divaricata root extract; 1020 parts olive fruit extract; and 812 parts solvent. This invention has the effect of relieving stress response to skin redness and itching and soothing the skin.

[0005] However, the aforementioned technologies, in order to achieve the purpose of soothing and repairing, mostly involve adding moisturizers, ceramides, and various extracts to skin care products. This technology is based on the simple superposition of known effects, acting on the skin through external supplementation. The technical path is singular and does not fundamentally solve consumers' pain points. Moreover, although ceramides can provide exogenous moisturizing effects, they do not make significant contributions to endogenous repair, anti-inflammatory and other effects. They are expensive, difficult to dissolve in water, and are usually added in low amounts, which restricts their application in cosmetics.

[0006] Therefore, it is of great significance to develop a product that soothes and repairs the skin from the inside out through multiple angles and pathways. Summary of the Invention

[0007] This invention addresses the problems existing in the prior art by providing a skin soothing and repairing composition, its preparation method, and its application.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] A skin-soothing and repairing composition comprising the following components: oligopeptide-215, sodium DNA, ceramide NP, and cetyl-PG hydroxyethyl palmitamide.

[0010] Preferably, the components further include humectants, thickeners, pH adjusters, and preservatives.

[0011] Preferably, the moisturizer is selected from one or more of glycerin, butylene glycol, and 1,3-propanediol.

[0012] Preferably, the thickener is selected from carbomer or acrylate / C10-30 alkanol acrylate crosspolymers.

[0013] Preferably, the pH adjuster is selected from any one of arginine, triethanolamine, and aminomethylpropanol.

[0014] Preferably, the preservative is selected from one or more of 1,2-pentanediol, 1,2-hexanediol, and p-hydroxyacetophenone.

[0015] Preferably, the components further include excipients and water, wherein the excipients are selected from one or more of hydrogenated lecithin, palmitic acid, stearic acid, and phytosterols / behenols / octyldodecyl lauroyl glutamate.

[0016] Preferably, the skin soothing and repairing composition further comprises, by weight percentage: 0.0001-0.005% oligopeptide-215, 0.00055-0.0055% sodium DNA, 0.01-1% ceramide NP, 0.1-6% cetyl-PG hydroxyethyl palmitamide, 5-20% moisturizer, 0.05-0.5% thickener, 0.05-0.5% pH adjuster, 0.5-5% preservative, 1-30% excipients, and the balance being water.

[0017] More preferably, by weight percentage, the skin soothing and repairing composition comprises the following components: oligopeptide-215 0.0001-0.002%, sodium DNA 0.00055-0.003%, ceramide NP 0.01-0.2%, cetyl-PG hydroxyethyl palmitamide 0.1-6%, moisturizer 10-20%, thickener 0.2-0.4%, pH adjuster 0.2-0.4%, preservative 3-5%, excipients 2-6%, and the balance being water.

[0018] The present invention also provides a method for preparing the above-mentioned skin soothing and repairing composition, comprising the following steps:

[0019] (1) Mix the humectant, thickener and water to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP and excipients to obtain phase B, and then add phase B to phase A to obtain a mixture.

[0020] (2) Mix the pH adjuster with water to obtain phase C; mix sodium DNA, oligopeptide-215 with preservatives to obtain phase D;

[0021] (3) Add phase C and phase D to the mixture from step (1) and let it stand to obtain the final product.

[0022] Preferably, in step (1), the mixture is heated and stirred until homogeneous, the heating temperature is 80-85℃, the stirring speed is 150-200rpm, and the stirring time is 5-10min.

[0023] Preferably, in step (1), after phase B is added to phase A, homogenization and stirring are performed. The homogenization speed is 3000-5000 rpm and the homogenization time is 3-5 min. The stirring speed is 150-200 rpm and the stirring time is 5-10 min.

[0024] Preferably, the mixing in step (2) is carried out by stirring at 150-200 rpm for 5-10 min.

[0025] Preferably, when adding phase C and phase D to the mixture in step (1) in step (3), the mixture in step (1) should be cooled to 40-45°C first, then phase C should be added, and the mixture should be stirred at 150-200 rpm for 5-10 minutes until homogeneous. Finally, phase D should be added, and the mixture should be stirred at 150-200 rpm for 5-10 minutes until homogeneous.

[0026] The present invention also provides the application of the above-mentioned skin soothing and repairing composition in cosmetics.

[0027] Preferably, the dosage form of the cosmetic is an aqueous solution, emulsion, cream, gel, or mask.

[0028] Compared with the prior art, the present invention has the following advantages:

[0029] (1) In the skin soothing and repair combination of the present invention, oligopeptide-215 and sodium DNA are selected as endogenous soothing and repair components; ceramide NP and cetyl-PG hydroxyethyl palmitamide are selected as exogenous supplementary lipid components. The present invention solves the problem from the inside out by combining endogenous soothing and repair with exogenous supplementary lipids, thus fundamentally solving skin problems.

[0030] (2) Oligopeptide-215 promotes the expression of filaggrin and naupliin, the main components of the stratum corneum, improves the skin barrier function, and reduces transepidermal water loss; at the same time, oligopeptide-215 can effectively inhibit pro-inflammatory cytokines and erythematous factors, improve skin redness, and thus soothe and repair the skin.

[0031] (3) Sodium DNA participates in activating A2A adenosine receptors on the surface of specific cells, thereby promoting the release of cytokines, producing anti-inflammatory effects, and repairing damaged cells; in addition, VEGF, angiogenesis and glutamine transferase II are also released with the activation of A2A adenosine receptors, accelerating skin cell regeneration, thereby achieving soothing and repair at the cellular level.

[0032] (4) Cetyl-PG hydroxyethyl palmitamide is a type of ceramide that has the same efficacy as ceramide NP, but its price is only one-twentieth of that of ceramide NP. Combining ceramide-like substances with ceramide can greatly improve the economic value of the product.

[0033] (5) Ceramide NP, as an important physiological lipid of the stratum corneum, forms a network structure in the stratum corneum, increases the thickness of the stratum corneum, improves the skin's water-holding capacity, and achieves skin repair effects. The preparation process of this invention can improve the solubility of ceramide NP, increase the amount added, and enhance the product's efficacy. Detailed Implementation

[0034] It is worth noting that the raw materials used in this invention are all commercially available products, including carbomer, which is of the following type: 980 Polymer, purchased from Lubrizol Specialty Chemicals Manufacturing (Shanghai) Co., Ltd.; acrylate / C10-30 alkanol acrylate crosspolymer, model number... Ultrez 21Polymer, purchased from Lubrizol Specialty Chemicals Manufacturing (Shanghai) Co., Ltd.; Phytosterol / Behenol / Ocyldodecyl Lauroyl Glutamate, model ELDEW PS-306, purchased from Ajinomoto Co., Ltd., Japan.

[0035] Example 1

[0036] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 0.1% cetyl-PG hydroxyethyl palmitamide, 0.01% ceramide NP, 0.3% arginine, 0.00055% sodium DNA, 0.0001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0037] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0038] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0039] (2) Mix arginine with water and stir at 150 rpm for 10 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0040] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0041] Example 2

[0042] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 1% cetyl-PG hydroxyethyl palmitamide, 0.05% ceramide NP, 0.3% arginine, 0.00165% sodium DNA, 0.0005% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0043] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0044] (1) Mix glycerol, carbomer and water, heat to 85°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 85°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 5000 rpm for 3 min, stir at 150 rpm for 10 min until uniform to obtain a mixture.

[0045] (2) Mix arginine with water and stir at 150 rpm for 10 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 200 rpm for 5 min until homogeneous to obtain phase D.

[0046] (3) Cool the mixture from step (1) to 40°C, add phase C, stir at 200 rpm for 5 min until uniform; then add phase D, stir at 200 rpm for 5 min until uniform, discharge, let stand, and you will get the product.

[0047] Example 3

[0048] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide NP, 0.3% arginine, 0.00275% sodium DNA, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0049] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0050] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0051] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0052] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0053] Example 4

[0054] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecanol lauroyl glutamate, 4% cetyl-PG hydroxyethyl palmitamide, 0.5% ceramide NP, 0.3% arginine, 0.0044% sodium DNA, 0.003% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0055] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0056] (1) Mix glycerol, carbomer and water, heat to 85°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 85°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 5000 rpm for 3 min, stir at 150 rpm for 10 min until uniform to obtain a mixture.

[0057] (2) Mix arginine with water and stir at 200 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 10 min until homogeneous to obtain phase D.

[0058] (3) Cool the mixture from step (1) to 40°C, add phase C, stir at 200 rpm for 5 min until uniform; then add phase D, stir at 200 rpm for 5 min until uniform, discharge, let stand, and you will get the product.

[0059] Example 5

[0060] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecanol lauroyl glutamate, 6% cetyl-PG hydroxyethyl palmitamide, 1% ceramide NP, 0.3% arginine, 0.0055% sodium DNA, 0.005% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0061] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0062] (1) Mix glycerol, carbomer and water, heat to 85°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 85°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 5000 rpm for 3 min, stir at 150 rpm for 10 min until uniform to obtain a mixture.

[0063] (2) Mix arginine with water and stir at 150 rpm for 10 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 200 rpm for 5 min until homogeneous to obtain phase D.

[0064] (3) Cool the mixture from step (1) to 40°C, add phase C, stir at 200 rpm for 5 min until uniform; then add phase D, stir at 200 rpm for 5 min until uniform, discharge, let stand, and you will get the product.

[0065] Example 6

[0066] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 5% butylene glycol, 0.05% acrylate / C10-30 alkanol acrylate crosspolymer, 10% phytosterol / behenol / octyldodecyl lauroyl glutamate, 10% palmitic acid, 10% stearic acid, 0.1% cetyl-PG hydroxyethyl palmitamide, 0.01% ceramide NP, 0.05% triethanolamine, 0.00055% sodium DNA, 0.0001% oligopeptide-215, 2% 1,2-hexanediol, 3% 1,2-pentanediol, with the balance being water.

[0067] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0068] (1) Mix glycerol, butanediol, acrylate / C10-30 alkanol acrylate crosspolymer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix phytosterol / behenol / octyldodecyl lauroyl glutamate, ceramide NP, cetyl-PG hydroxyethyl palmitamide, stearic acid and palmitic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0069] (2) Mix triethanolamine with water and stir at 200 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215, 1,2-hexanediol and 1,2-pentanediol and stir at 150 rpm for 10 min until homogeneous to obtain phase D.

[0070] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0071] Example 7

[0072] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 5% butylene glycol, 0.5% acrylate / C10-30 alkanol acrylate crosspolymer, 1% hydrogenated lecithin, 6% cetyl-PG hydroxyethyl palmitamide, 1% ceramide NP, 0.5% aminomethylpropanol, 0.0055% sodium DNA, 0.005% oligopeptide-215, 0.5% hydroxyacetophenone, and the balance being water.

[0073] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0074] (1) Mix butanediol, acrylate / C10-30 alkanol acrylate crosspolymer and water, heat to 85°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP and hydrogenated lecithin, heat to 85°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 5000 rpm for 3 min, stir at 150 rpm for 10 min until uniform to obtain a mixture.

[0075] (2) Mix aminomethylpropanol with water to obtain phase C; mix sodium DNA, oligopeptide-215, hydroxyacetophenone with water and stir at 200 rpm for 5 min until uniform to obtain phase D.

[0076] (3) Cool the mixture from step (1) to 40°C, add phase C, stir at 200 rpm for 5 min until uniform; then add phase D, stir at 200 rpm for 5 min until uniform, discharge, let stand, and you will get the product.

[0077] Comparative Example 1

[0078] The only difference from Example 3 is that a composition is provided that does not contain cetyl-PG hydroxyethyl palmitamide, ceramide NP, sodium DNA, and oligopeptide-215.

[0079] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 0.3% arginine, 4% 1,2-pentanediol, and the balance being water.

[0080] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0081] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0082] (2) Mix arginine with water and stir at 150 rpm for 5 minutes until the mixture is homogeneous to obtain phase C.

[0083] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add 1,2-pentanediol, stir at 150 rpm for 10 min until uniform, discharge, let stand, and the product is obtained.

[0084] Comparative Example 2

[0085] The only difference from Example 3 is that a skin-soothing and repairing composition free of cetyl-PG hydroxyethyl palmitamide is provided.

[0086] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 0.1% ceramide NP, 0.3% arginine, 0.00275% sodium DNA, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0087] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0088] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0089] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0090] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0091] Comparative Example 3

[0092] The only difference from Example 3 is that a skin-soothing and repairing composition without ceramide NP is provided.

[0093] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.3% arginine, 0.00275% sodium DNA, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0094] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0095] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0096] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0097] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0098] Comparative Example 4

[0099] The only difference from Example 3 is that a skin-soothing and repairing composition without sodium DNA is provided.

[0100] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide NP, 0.3% arginine, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0101] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0102] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0103] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0104] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0105] Comparative Example 5

[0106] The only difference from Example 3 is that a skin-soothing and repairing composition without oligopeptide-215 is provided.

[0107] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide NP, 0.3% arginine, 0.00275% sodium DNA, 4% 1,2-pentanediol, and the balance being water.

[0108] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0109] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0110] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0111] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0112] Comparative Example 6

[0113] The only difference from Example 3 is that a skin-soothing and repairing composition is provided in which ceramide NP is replaced with ceramide AP.

[0114] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide AP, 0.3% arginine, 0.00275% sodium DNA, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0115] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0116] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide AP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0117] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0118] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0119] Comparative Example 7

[0120] The only difference from Example 3 is that a skin-soothing and repairing composition is provided in which cetyl-PG hydroxyethyl palmitamide is replaced with N-palmitoyl hydroxyproline cetyl ester.

[0121] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% N-palmitoyl hydroxyproline cetyl ester, 0.1% ceramide NP, 0.3% arginine, 0.00275% sodium DNA, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0122] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0123] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix N-palmitoyl hydroxyproline cetyl ester, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyl dodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0124] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0125] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0126] Comparative Example 8

[0127] The only difference from Example 3 is that a skin-soothing and repairing composition is provided in which sodium DNA is replaced with sturgeon caviar extract.

[0128] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecanol lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide NP, 0.3% arginine, 0.00275% sturgeon caviar extract, 0.001% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0129] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0130] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0131] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sturgeon caviar extract, oligopeptide-215 and 1,2-pentanediol and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0132] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0133] Comparative Example 9

[0134] The only difference from Example 3 is that a skin-soothing and repairing composition is provided in which oligopeptide-215 is replaced with tripeptide-1 copper.

[0135] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 2% cetyl-PG hydroxyethyl palmitamide, 0.1% ceramide NP, 0.3% arginine, 0.00275% sodium DNA, 0.001% tripeptide-1 copper, 4% 1,2-pentanediol, and the balance being water.

[0136] A skin-soothing and repairing composition, the preparation method of which includes the following steps:

[0137] (1) Mix glycerol, carbomer and water, heat to 80°C, stir at 200 rpm for 5 min until uniform and free of particles to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP, hydrogenated lecithin, phytosterol / behenol / octyldodecyl lauroyl glutamate and stearic acid, heat to 80°C, stir at 150 rpm for 10 min until uniform and free of particles to obtain phase B; add phase B to phase A, homogenize at 3000 rpm for 5 min, stir at 200 rpm for 5 min until uniform to obtain a mixture.

[0138] (2) Mix arginine with water and stir at 150 rpm for 5 min until homogeneous to obtain phase C; mix sodium DNA, tripeptide-1 copper, 1,2-pentanediol with water and stir at 150 rpm for 5 min until homogeneous to obtain phase D.

[0139] (3) Cool the mixture from step (1) to 45°C, add phase C, stir at 150 rpm for 10 min until uniform; then add phase D, stir at 150 rpm for 10 min until uniform, discharge, let stand, and you will get the product.

[0140] Comparative Example 10

[0141] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 0.08% cetyl-PG hydroxyethyl palmitamide, 0.008% ceramide NP, 0.3% arginine, 0.00044% sodium DNA, 0.00008% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0142] The preparation method of this skin soothing and repairing composition is the same as that in Example 3.

[0143] Comparative Example 11

[0144] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 0.05% cetyl-PG hydroxyethyl palmitamide, 0.005% ceramide NP, 0.3% arginine, 0.000275% sodium DNA, 0.00005% oligopeptide-215, 4% 1,2-pentanediol, with the balance being water.

[0145] The preparation method of this skin soothing and repairing composition is the same as that in Example 3.

[0146] Comparative Example 12

[0147] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 6.5% cetyl-PG hydroxyethyl palmitamide, 1.2% ceramide NP, 0.3% arginine, 0.0066% sodium DNA, 0.0055% oligopeptide-215, 4% 1,2-pentanediol, and the balance being water.

[0148] The preparation method of this skin soothing and repairing composition is the same as that in Example 3.

[0149] Comparative Example 13

[0150] A skin-soothing and repairing composition, by weight percentage, comprises the following components: 15% glycerin, 0.3% carbomer, 1.5% hydrogenated lecithin, 1% stearic acid, 1.5% phytosterol / behenol / octyldodecyl lauroyl glutamate, 7% cetyl-PG hydroxyethyl palmitamide, 1.5% ceramide NP, 0.3% arginine, 0.00825% sodium DNA, 0.006% oligopeptide-215, 4% 1,2-pentanediol, and the balance being water.

[0151] The preparation method of this skin soothing and repairing composition is the same as that in Example 3.

[0152] Experiment 1 Cold and Heat Resistance Stability Test

[0153] The skin soothing and repairing compositions prepared in Examples 1-7 and Comparative Examples 1-13 were subjected to cold and heat resistance stability tests. The cold resistance test was conducted in a constant temperature refrigerator at -15℃, the heat resistance test was conducted in a constant temperature incubator at 45℃, and the cold and heat cycle test was conducted in an incubator with temperature cycles of -10℃ and 40℃. The test was conducted for 12 weeks. The samples that showed no significant change compared with the samples placed at 25℃ for 12 weeks were considered qualified. The results are shown in Table 1.

[0154] Table 1 Stability Test Results

[0155]

[0156] Table 1 shows the results: Examples 1-7 and Comparative Examples 1-9 passed the stability test; Comparative Examples 10-11 failed the stability test due to low composition content and low sample viscosity, resulting in demulsification; Comparative Examples 12-13 failed the stability test due to high composition content, resulting in particle precipitation. This indicates that both composition content below and above the scope of protection of this invention will cause the stability test to fail.

[0157] Experiment 2 Efficacy Test

[0158] 1. Test Plan

[0159] Three Asian adult subjects were selected for each group, and the test site was the inner forearm of the hand. Skin reddening was induced by capsaicin stimulation. A single application of the sample (the skin-soothing and repairing compositions prepared in Examples 1-7 and Comparative Examples 1-13) was performed. The results were compared between the experimental group before application (T0) after capsaicin stimulation and 30 minutes after application (T...). 0.5h The changes in skin stratum corneum moisture content, transepidermal water loss (TEWL), and skin erythema index (a* value) were observed to evaluate the moisturizing, skin barrier repair, and redness-relieving effects of the samples. The blank cases were those without capsaicin stimulation and without sample application.

[0160] 2. Sample Usage Instructions

[0161] According to the random table, the technician used an adjustable pipette to transfer the test sample at a concentration of 2.0 ± 0.1 mg / cm³. 2 Apply the amount to the test area once.

[0162] 3. Data Statistical Methods

[0163] (1) Descriptive statistics

[0164] Descriptive statistics include quantity, mean, standard deviation, maximum, median, and minimum.

[0165] (2) Rate of change

[0166] rate of change = (T) n -T0) / T0×100%

[0167] Where T0 represents the moisture content of the stratum corneum of the skin before using the sample, T n This represents the moisture content of the stratum corneum of the skin after using the sample.

[0168] 4. Parameter Explanation:

[0169] (1) Skin stratum corneum moisture content: The higher the value, the more sufficient the skin stratum corneum moisture content.

[0170] (2) Transepidermal water loss rate (TEWL): The smaller the value, the less water is lost per unit area and time of skin, and the better the skin barrier function.

[0171] (3) Skin erythema index (a* value): The smaller the value, the less red the skin is.

[0172] 5. Test Results

[0173] (1) The results of the changes in skin stratum corneum moisture content, transepidermal water loss (TEWL) rate, and skin erythema index (a* value) are shown in Table 2.

[0174] Table 2 Efficacy Test

[0175]

[0176]

[0177] (1) Based on the test results in Table 2, we can conclude that:

[0178] A. Compared with the blank example, the change rate of skin stratum corneum moisture content in Examples 1-7 of the present invention all increased significantly and showed an increasing trend, indicating that Examples 1-7 all have significant moisturizing effects, and the effect increases with the increase of the amount of composition added.

[0179] B. Compared with the blank example, the change rate of transepidermal water loss (TEWL) in Examples 1-7 of the present invention was significantly reduced (the smaller the value, the better the skin barrier function), showing a decreasing trend, indicating that Examples 1-7 all have significant skin barrier repair effects, and the effect increases with the increase of the amount of composition added.

[0180] C. Compared with the blank example, the change rate of skin erythema index (a* value) in Examples 1-7 of the present invention was significantly reduced (the smaller the value, the better the soothing effect), showing a decreasing trend, indicating that Examples 1-7 all have significant skin soothing effects, and the effect increases with the increase of the amount of composition added.

[0181] D. Comparative Example 1 does not contain the composition of the present invention. The skin stratum corneum moisture content change rate, transepidermal water loss rate (TEWL) change rate, and skin erythema index (a* value) change rate of Examples 1-7 of the present invention are all better than those of Comparative Example 1, further demonstrating that the present invention has significant moisturizing, skin barrier repair, and skin soothing effects.

[0182] (2) Further analysis of the test results of Example 3 and Comparative Examples 2-13:

[0183] A. Comparative Example 2 does not contain cetyl-PG hydroxyethyl palmitamide, Comparative Example 3 does not contain ceramide NP, Comparative Example 4 does not contain sodium DNA, and Comparative Example 5 does not contain oligopeptide-215. The changes in skin stratum corneum moisture content, transepidermal water loss (TEWL) rate, and skin erythema index (a* value) of Comparative Examples 2-5 are all worse than those of Example 3, indicating that the absence of any component in the composition of the present invention will affect the efficacy of the composition and reduce its efficacy.

[0184] B. In Comparative Example 6, ceramide NP was replaced with ceramide AP; in Comparative Example 7, cetyl-PG hydroxyethyl palmitamide was replaced with N-palmitoyl hydroxyproline cetyl ester; in Comparative Example 8, sodium DNA was replaced with sturgeon caviar extract; and in Comparative Example 9, oligopeptide-215 was replaced with tripeptide-1 copper. The changes in skin stratum corneum moisture content, transepidermal water loss (TEWL), and skin erythema index (a* value) of Comparative Examples 6-9 were all worse than those of Example 3. This indicates that replacing the components of the soothing and repairing composition provided by the present invention with existing, recognized, and effective similar ingredients cannot achieve the same efficacy. The skin soothing and repairing composition of the present invention is not a simple substitution between components.

[0185] C. The skin soothing and repairing composition content of Comparative Examples 10-11 is lower than the protection range of the composition of the present invention, while the skin soothing and repairing composition content of Comparative Examples 12-13 is higher than the protection range of the composition of the present invention. The change rates of skin stratum corneum moisture content, transepidermal water loss (TEWL) rate, and skin erythema index (a* value) of Comparative Examples 10-13 are all worse than those of Examples 1-5. This indicates that the composition content being lower or higher than the content range of the components of the present invention will affect the efficacy by affecting the stability of the sample. Only within the content range of the components of the present invention can the best stability and the best efficacy be achieved.

[0186] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A skin-soothing and repairing composition, characterized in that, The skin soothing and repairing composition comprises, by weight percentage: oligopeptide-215 0.0001-0.005%, sodium DNA 0.00055-0.0055%, ceramide NP 0.01-1%, cetyl-PG hydroxyethyl palmitamide 0.1-6%, moisturizer 5-20%, thickener 0.05-0.5%, pH adjuster 0.05-0.5%, preservative 0.5-5%, excipients 1-30%, and the balance being water.

2. The skin-soothing and repairing composition according to claim 1, characterized in that, The humectant is selected from one or more of glycerin, butylene glycol, and 1,3-propanediol; the thickener is selected from carbomer or acrylate / C10-30 alkanol acrylate crosspolymers; the pH adjuster is selected from any one of arginine, triethanolamine, and aminomethylpropanol; and the preservative is selected from one or more of 1,2-pentanediol, 1,2-hexanediol, and p-hydroxyacetophenone.

3. The skin-soothing and repairing composition according to claim 1, characterized in that, The excipients are selected from one or more of hydrogenated lecithin, palmitic acid, stearic acid, and phytosterol / behenol / octyldodecyl lauroyl glutamate.

4. The skin-soothing and repairing composition according to claim 1, characterized in that, The skin soothing and repairing composition comprises, by weight percentage, the following components: oligopeptide-215 0.0001-0.002%, sodium DNA 0.00055-0.003%, ceramide NP 0.01-0.2%, cetyl-PG hydroxyethyl palmitamide 0.1-6%, moisturizer 10-20%, thickener 0.2-0.4%, pH adjuster 0.2-0.4%, preservative 3-5%, excipients 2-6%, and the balance being water.

5. A method for preparing a skin-soothing and repairing composition as described in any one of claims 1-4, characterized in that, Includes the following steps: (1) Mix the humectant, thickener and water to obtain phase A; mix cetyl-PG hydroxyethyl palmitamide, ceramide NP and excipients to obtain phase B, and then add phase B to phase A to obtain a mixture; (2) Mix the pH adjuster with water to obtain phase C; mix sodium DNA, oligopeptide-215 with preservatives to obtain phase D; (3) Add phase C and phase D to the mixture in step (1) and let it stand to obtain the final product.

6. The preparation method according to claim 5, characterized in that, In step (1), the mixture is heated and stirred until homogeneous. The heating temperature is 80-85℃, the stirring speed is 150-200 rpm, and the stirring time is 5-10 min. In step (1), after phase B is added to phase A, it is also homogenized and stirred. The homogenization speed is 3000-5000 rpm, the homogenization time is 3-5 min, the stirring speed is 150-200 rpm, and the stirring time is 5-10 min. In step (2), the mixture is stirred at 150-200 rpm for 5-10 min. When adding phase C and phase D to the mixture in step (1) as described in step (3), the mixture in step (1) should be cooled to 40-45℃ first, then phase C should be added, and the mixture should be stirred at 150-200 rpm for 5-10 min until homogeneous. Finally, phase D should be added, and the mixture should be stirred at 150-200 rpm for 5-10 min until homogeneous.

7. The use of a skin soothing and repairing composition as described in any one of claims 1-4 or a skin soothing and repairing composition obtained by the preparation method as described in any one of claims 5-6 in the preparation of cosmetics.

8. The application according to claim 7, characterized in that, The cosmetic product is in the form of an aqueous solution, lotion, cream, gel, or mask.

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