A disinfectant for aquatic products containing a block copolymer complex iodine and a preparation method thereof

Abstract

The application discloses an aquaculture disinfectant containing block copolymer complex iodine and belongs to the technical field of iodine disinfectants. The disinfectant comprises the following components: iodine 0.5%-5.0%, a surfactant carrier 0.5%-40%, acid 1%-20%, a cosolvent 0-4%, and water as the balance. The surfactant carrier comprises one or more of dodecylbenzyl polyoxyethylene ether, dodecylbenzyl polyoxyethylene polyoxypropylene block polyether, C12-C16 alkyl trimethyl ammonium chloride and C12-C16 alkyl dimethyl benzyl ammonium chloride. The surfactant carrier containing benzyl is complexed with iodine to obtain complex iodine. Since negative ions in a high-salt solution and the complex iodine with negative electricity repel each other, the activity of the complex iodine is increased after the complex iodine is poured into the high-salt solution, the complex iodine moves quickly, and the complex iodine is rapidly dispersed in the solution, thereby having the effects of solubilization and stabilization.

Description

Technical Field

[0001] This invention relates to the field of iodine disinfectant technology, specifically to a disinfectant for aquaculture containing block copolymer complexed iodine and its preparation method. Background Technology

[0002] Disinfectants are the most commonly used drugs in aquaculture, used to eliminate or kill pathogenic microorganisms and other harmful microorganisms in the external environment. Compound iodine is formulated with iodine, phosphoric acid, surfactants, etc., and is one of the most stable and effective iodine-based disinfectants. However, most compound iodine can only be used in freshwater aquaculture because of its poor salt tolerance; it tends to clump together in salt water of around 3%, making it unsuitable for use in near-shore areas. Furthermore, the surfactant used is nonylphenol polyoxyethylene ether (NPEOn), which was once the second most widely used nonionic surfactant globally. It possesses excellent emulsifying, solubilizing, wetting, and detergency properties, and is widely used in civilian and industrial cleaning, as well as in fine chemicals. However, NPEOn has poor biodegradability and high environmental toxicity. Compound iodine made from NPEOn can affect aquatic organisms, and after being absorbed by aquatic species, it can eventually enter the human body, potentially causing reproductive abnormalities.

[0003] Commonly used nonionic surfactants such as fatty alcohol polyoxyethylene ethers and phenoxylates exhibit poor stability in high-salt environments due to the compression of the surface double layer caused by inorganic electrolytes, resulting in a decrease in electrokinetic potential and reduced electrostatic repulsion between particles. Summary of the Invention

[0004] To address the aforementioned issues, this invention proposes a disinfectant for aquaculture containing block copolymer-complexed iodine and its preparation method. While possessing environmentally friendly properties, it also exhibits stability of iodine in high-concentration salt environments, making it suitable for both freshwater and marine aquaculture.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solution:

[0006] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine 0.5%-5.0%, surfactant carrier 0.5%-40%, acid 1%-20%, cosolvent 0-4%, and the balance being water.

[0007] Furthermore, the surfactant carrier comprises a mixture of nonionic and cationic surfactants.

[0008] Furthermore, the nonionic surfactant includes one or more of the following: dodecyl benzyl polyoxyethylene ether-2, dodecyl benzyl polyoxyethylene ether-4, dodecyl benzyl polyoxyethylene ether-6, dodecyl benzyl polyoxyethylene ether-8, dodecyl benzyl polyoxyethylene ether-10, dodecyl benzyl polyoxyethylene ether-12, and dodecyl benzyl polyoxyethylene polyoxypropylene block polyether.

[0009] Furthermore, the chemical formula of the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is: R-C6H4CH2-O-(C2H4O)n(C3H6O)m(C2H4O)nH, where R is a straight-chain alkyl group of C8-C16.

[0010] Furthermore, in the chemical formula, n is 2-150 and m is 10-50.

[0011] Furthermore, the cationic surfactant is any one or more of C12-C16 alkyltrimethylammonium chloride and C12-C16 alkyldimethylbenzylammonium chloride.

[0012] Furthermore, the alkyl dimethyl benzyl ammonium chloride is a C12-C16 alkyl dimethyl benzyl ammonium chloride.

[0013] Furthermore, the acid is any one or more of citric acid, hydrochloric acid, phosphoric acid, and sulfuric acid.

[0014] Furthermore, the stabilizer is any one of sorbitol, glycerol, ethanol, ethylene glycol, and propylene glycol.

[0015] This invention also protects a method for preparing an aquatic disinfectant containing block copolymer complexed iodine, comprising the following steps:

[0016] (1) Add surfactant carrier and elemental iodine to the reaction apparatus, start stirring, and stir for 2-3 hours at 40℃-50℃ until the iodine is completely dissolved.

[0017] (2) After adding the stabilizer, stir for 1-2 hours to dissolve and dilute the acid, then add it to the reaction device and make up the remaining water to obtain aquatic disinfectant containing block copolymer complexed iodine.

[0018] The present invention relates to a disinfectant for aquaculture containing block copolymer complexed iodine and its preparation method, the advantages of which are as follows:

[0019] 1. The surfactant carrier of the present invention contains a benzyl group, which is a methyl group that replaces a hydrogen atom on the benzene ring. This makes the generated benzyl group negatively charged and repels the large number of chloride ions in the cationic surfactant, thus avoiding the phenomenon of aggregation of composite iodine in high-concentration salt solutions.

[0020] 2. The present invention uses a benzyl surfactant carrier to complex with iodine to obtain complexed iodine. Since the negative ions in the high-salt solution repel each other with the negatively charged complexed iodine, the activity of the complexed iodine will increase after it is poured into the high-salt solution. It will move rapidly and disperse quickly in the solution, thus having the effects of solubilization and stabilization.

[0021] 3. The block copolymer surfactant of the present invention is a biodegradable organic compound with low irritation to water and aquatic plants and animals. Because it is a linear chain, it degrades faster and produces carbon dioxide and water after degradation, which will not irritate the water and is friendly to aquatic plants and animals. Detailed Implementation

[0022] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be clearly and completely described below with reference to embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine 0.5%-5.0%, surfactant carrier 0.5%-40%, acid 1%-20%, cosolvent 0-4%, and the balance being water.

[0024] It should be further noted that the surfactant carrier includes a mixture of nonionic and cationic surfactants.

[0025] It should be further noted that the nonionic surfactant includes one or more of the following: dodecyl benzyl polyoxyethylene ether-2, dodecyl benzyl polyoxyethylene ether-4, dodecyl benzyl polyoxyethylene ether-6, dodecyl benzyl polyoxyethylene ether-8, dodecyl benzyl polyoxyethylene ether-10, dodecyl benzyl polyoxyethylene ether-12, and dodecyl benzyl polyoxyethylene polyoxypropylene block polyether.

[0026] Preferably, the nonionic surfactant is dodecylbenzyl polyoxyethylene polyoxypropylene block polyether, wherein the chemical formula of the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is:

[0027] R-C6H4CH2-O-(C2H4O)n(C3H6O)m(C2H4O)nH, wherein R is a C8-C16 straight-chain alkyl group; in the chemical formula, n is 2-150 and m is 10-50. More preferably, n is 10-40 and m is 10-40.

[0028] A method for preparing dodecylbenzyl polyoxyethylene polyoxypropylene block polyether includes the following steps:

[0029] (1) Dodecylbenzene and formaldehyde were placed in a reaction vessel and stirred at 80°C for 3 hours in the presence of anhydrous zinc chloride and excess glacial acetic acid. During this period, dry hydrogen chloride gas was introduced. After the reaction, the upper organic phase was analyzed by cooling. The upper organic phase was extracted with petroleum ether 2-3 times, washed with sodium carbonate and water until neutral, and distilled under reduced pressure to obtain the intermediate. The intermediate was hydrolyzed in the presence of appropriate catalysts tetraethylammonium bromide and potassium carbonate to obtain dodecylbenzyl alcohol.

[0030] (2) Dodecyl benzyl alcohol and polyoxyethylene polyoxypropylene block copolymer were reacted under the conditions of acidic catalyst sulfuric acid and 110°C for 4 hours to obtain dodecyl benzyl polyoxyethylene polyoxypropylene block polyether; the mass ratio of dodecyl benzyl alcohol to polyoxyethylene polyoxypropylene block copolymer in this step was 1:1.

[0031] The average molecular weight of the polyoxyethylene-polyoxypropylene block copolymer in the dodecylbenzyl polyoxyethylene-polyoxypropylene block polyether is 500-10000. Preferably, the average molecular weight of the polyoxyethylene-polyoxypropylene block copolymer is 500-4000.

[0032] In the chemical formula described in step (2) above, n is 2-150 and m is 10-50; more preferably, in the chemical formula described in step (2) above, n is 5-40 and m is 5-30.

[0033] It should be further noted that the cationic surfactant is any one or more of C12-C16 alkyltrimethylammonium chloride and C12-C16 alkyldimethylbenzylammonium chloride.

[0034] Example 1

[0035] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine (99.9% available iodine) 5.0%, dodecyl benzyl polyoxyethylene polyoxypropylene block polyether 20%, dodecyl dimethyl benzyl ammonium chloride 10%, phosphoric acid 20%, and the balance being water.

[0036] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2000.

[0037] The preparation method of the disinfectant in this embodiment is as follows:

[0038] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0039] (2) After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0040] Example 2

[0041] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 1% iodine (99.9% available iodine), 5% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 5% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, and the balance being water.

[0042] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2500.

[0043] The preparation method of the disinfectant in this embodiment is as follows:

[0044] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0045] (2) After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0046] Example 3

[0047] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 20% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 5% dodecyl dimethyl benzyl ammonium chloride, 15% phosphoric acid, and the balance being water.

[0048] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2000.

[0049] The preparation method of the disinfectant in this embodiment is as follows:

[0050] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0051] (2) After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0052] Example 3

[0053] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 3% iodine (99.9% available iodine), 30% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl dimethyl benzyl ammonium chloride, 15% phosphoric acid, and the balance being water.

[0054] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2000.

[0055] The preparation method of the disinfectant in this embodiment is as follows:

[0056] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0057] (2) After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0058] Example 4

[0059] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine (99.9% available iodine) 0.5%, dodecyl benzyl polyoxyethylene polyoxypropylene block polyether 5%, dodecyl dimethyl benzyl ammonium chloride 2%, phosphoric acid 5%, and the balance being water.

[0060] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2000.

[0061] The preparation method of the disinfectant in this embodiment is as follows:

[0062] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0063] (2) After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0064] Example 5

[0065] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0066] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 2000.

[0067] The preparation method of the disinfectant in this embodiment is as follows:

[0068] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0069] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0070] Example 6

[0071] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0072] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1000.

[0073] The preparation method of the disinfectant in this embodiment is as follows:

[0074] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0075] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0076] Example 7

[0077] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0078] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1800.

[0079] The preparation method of the disinfectant in this embodiment is as follows:

[0080] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0081] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0082] Example 8

[0083] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0084] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0085] The preparation method of the disinfectant in this embodiment is as follows:

[0086] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0087] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0088] Example 9

[0089] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine (99.9% available iodine) 2%, dodecyl benzyl polyoxyethylene polyoxypropylene block polyether 10%, tetradecyl dimethyl benzyl ammonium chloride 10%, phosphoric acid 10%, ethanol 3%, and the balance being water.

[0090] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0091] The preparation method of the disinfectant in this embodiment is as follows:

[0092] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add tetradecyldimethylbenzylammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0093] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0094] Example 10

[0095] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% hexadecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0096] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0097] The preparation method of the disinfectant in this embodiment is as follows:

[0098] (1) Add dodecylbenzylpolyoxyethylene polyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add hexadecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0099] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0100] Example 11

[0101] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% dodecyl trimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0102] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0103] The preparation method of the disinfectant in this embodiment is as follows:

[0104] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyltrimethylbenzylammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0105] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0106] Example 12

[0107] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% tetradecyltrimethylbenzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0108] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0109] The preparation method of the disinfectant in this embodiment is as follows:

[0110] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add tetradecyltrimethylbenzylammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0111] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0112] Example 13

[0113] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecylbenzyl polyoxyethylene polyoxypropylene block polyether, 10% hexadecyltrimethylbenzylammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0114] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0115] The preparation method of the disinfectant in this embodiment is as follows:

[0116] (1) Add dodecylbenzylpolyoxyethylene polyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add hexadecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0117] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0118] Example 14

[0119] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl dipolyoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0120] The preparation method of the disinfectant in this embodiment is as follows:

[0121] (1) Add dodecylbenzylpolyoxyethylenepolyoxypropylene block polyether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0122] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0123] Example 15

[0124] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: iodine 2%, dodecyl benzyl tetrapolyoxyethylene ether 10%, dodecyl dimethyl benzyl ammonium chloride 10%, phosphoric acid 10%, ethanol 3%, and the balance being water.

[0125] The preparation method of the disinfectant in this embodiment is as follows:

[0126] (1) Add dodecyl benzyl tetrapolyoxyethylene ether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0127] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0128] Example 16

[0129] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl hexaoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0130] The preparation method of the disinfectant in this embodiment is as follows:

[0131] (1) Add dodecyl benzyl hexaoxyethylene ether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0132] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0133] Example 17

[0134] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl octapolyoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0135] The preparation method of the disinfectant in this embodiment is as follows:

[0136] (1) Add dodecyl benzyl octaoxyethylene ether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0137] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0138] Example 18

[0139] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl decapolyoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0140] The preparation method of the disinfectant in this embodiment is as follows:

[0141] (1) Add dodecyl benzyl decapolyoxyethylene ether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine.

[0142] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0143] Example 19

[0144] A disinfectant for aquaculture containing block copolymer complexed iodine comprises the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl dodecyl polyoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0145] The preparation method of the disinfectant in this embodiment is as follows:

[0146] (1) Add dodecyl benzyl dodecyl polyoxyethylene ether and elemental iodine to the reaction apparatus in sequence, start stirring, stir for 2-3 hours at 40℃-50℃, then add dodecyl dimethyl benzyl ammonium chloride and stir for 1-2 hours to obtain complexed iodine;

[0147] (2) After adding stabilizer to the complexed iodine in step (1), stir for 1-2 hours. After dissolving and diluting the acid, add it to the reaction device and make up the remaining water to obtain a disinfectant for aquaculture containing block copolymer complexed iodine.

[0148] Comparative Example 1

[0149] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% lauryl alcohol decaethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0150] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0151] Comparative Example 2

[0152] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% alkyl glycoside, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0153] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0154] Comparative Example 3

[0155] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% nonylphenol polyoxyethylene ether, 10% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0156] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0157] Comparative Example 4

[0158] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 20% dodecyl dimethyl benzyl ammonium chloride, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0159] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0160] Comparative Example 5

[0161] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 20% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0162] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0163] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0164] Comparative Example 6

[0165] A disinfectant comprising the following components, by weight percentage: 2% iodine (99.9% available iodine), 10% dodecyl benzyl polyoxyethylene polyoxypropylene block polyether, 10% sodium dodecyl sulfonate, 10% phosphoric acid, 3% ethanol, and the balance being water.

[0166] In this embodiment, the average molecular weight of the polyoxyethylene polyoxypropylene block in the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is 1500.

[0167] This comparative disinfectant was prepared according to the preparation method of Example 8.

[0168] Testing and Inspection

[0169] 1. Salt tolerance test:

[0170] Corresponding reagents: disinfectants obtained in Examples 1-19 and Comparative Examples 1-6;

[0171] Salt solution preparation: Prepare a 100‰ seawater stock solution by mixing sea salt crystals and pure water at a mass ratio of 1:9. Then, prepare seawater sample solutions with concentrations of 10‰, 35‰, and 50‰ using the seawater stock solution and pure water (fill only 70ml of the sample solution into a 100ml glass tube for easy mixing).

[0172] Detection method: At room temperature, add 30 drops of the corresponding reagent to each of the above seawater samples. After each addition, stopper the test tube and shake thoroughly by inverting the tube. Record the phenomena of each sample at each seawater concentration (if no turbidity is observed after 30 drops, it is considered as complete salt tolerance). The results are shown in Table 1.

[0173] Table 1. Salt tolerance of disinfectants at room temperature

[0174]

[0175]

[0176] As shown in Table 1, the disinfectant of the present invention can achieve clarity and transparency even at a seawater concentration of 50‰. Compared with Example 8, Comparative Examples 1-3 showed poor salt resistance because the benzyl polyether of the present invention was replaced with alcohol ether, nonionic surfactant, and anionic surfactant, respectively, in Comparative Examples 1, 2, and 6. In Comparative Example 3, the benzyl polyether was replaced with nonylphenol polyoxyethylene ether, which improved the salt resistance; however, the decomposition of nonylphenol polyoxyethylene ether had an impact on the aquatic environment.

[0177] Although the solution shown in Comparative Example 4 was clear and transparent, the iodine in it was volatile, thus losing its disinfecting properties. Comparative Example 5, having removed the cationic surfactant, showed a decrease in its salt tolerance.

[0178] As can be seen from the data in Table 1, the present invention uses a specific nonionic surfactant alkylbenzyl polyether and a cationic surfactant alkylmethylbenzyl ammonium chloride to complex iodine. The resulting complexed iodine has good salt tolerance and can be used in high-salt or seawater aquaculture.

[0179] 2. Sterilization performance test

[0180] Corresponding reagents: Disinfectants obtained in Example 8 and Comparative Examples 1-6;

[0181] Salt solution preparation: Prepare a 100‰ seawater stock solution by mixing sea salt crystals and pure water at a mass ratio of 1:9. Then, prepare seawater sample solutions with concentrations of 10‰, 35‰, and 50‰ using the seawater stock solution and pure water (fill only 70ml of the sample solution into a 100ml glass tube for easy mixing).

[0182] Colony preparation: 2.5 ml of 50‰ seawater sample solution + 2.5 ml of nutrient broth + 100 μl of TOP bacterial solution were shaken and cultured in a constant temperature incubator at 28℃ for 24 h. Multiple colony growth samples were selected and their colony growth was observed (turbidity indicates bacterial growth, and clarity indicates no growth).

[0183] Control group: 2.5ml distilled water + 2.5ml nutrient broth + 100ul T0 bacterial culture, shaken and incubated.

[0184] The disinfectants obtained in Example 8 and Comparative Examples 1-6 were added to the colony growth sample solution and the blank group at a concentration of 0.1‰. Colony growth was observed at 24h and 48h, and the results are shown in Table 2.

[0185] Table 2 Colony growth

[0186]

[0187] As shown in Table 2, the present invention exhibits good bactericidal effect under high salt concentrations. However, Comparative Examples 2, 3, 5, and 6 showed a small amount of proliferation after 48 hours, indicating that sterilization was not thorough under high salt conditions.

[0188] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of the invention. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0189] Finally, it should be noted that the embodiments disclosed in this invention are merely preferred embodiments of this invention and are only used to illustrate the technical solutions of this invention, not to limit it. Although this invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this invention.

Claims

1. A disinfectant for aquaculture containing block copolymer complexed iodine, characterized in that: It includes the following components, by weight percentage: iodine 0.5%-5.0%, surfactant carrier 0.5%-40%, acid 1%-20%, cosolvent 0-4%, and the balance is water; The surfactant carrier comprises a mixture of nonionic and cationic surfactants; The nonionic surfactant includes one or more of the following: dodecyl benzyl polyoxyethylene ether-2, dodecyl benzyl polyoxyethylene ether-4, dodecyl benzyl polyoxyethylene ether-6, dodecyl benzyl polyoxyethylene ether-8, dodecyl benzyl polyoxyethylene ether-10, dodecyl benzyl polyoxyethylene ether-12, and dodecyl benzyl polyoxyethylene polyoxypropylene block polyether. The cation indicates that the active agent is any one or more of C12-C16 alkyltrimethylammonium chloride and C12-C16 alkyldimethylbenzylammonium chloride.

2. The aquatic disinfectant containing block copolymer complexed iodine according to claim 1, characterized in that: The chemical formula of the dodecylbenzyl polyoxyethylene polyoxypropylene block polyether is: R-C6H4CH2-O-(C2H4O)n(C3H6O)m(C2H4O)nH, where R is a straight-chain alkyl group of C8-C16.

3. The aquatic disinfectant containing block copolymer complexed iodine according to claim 2, characterized in that: In the chemical formula, n is 2-150 and m is 10-50.

4. The aquatic disinfectant containing block copolymer complexed iodine according to claim 1, characterized in that: The acid is any one or more of citric acid, hydrochloric acid, phosphoric acid, and sulfuric acid.

5. The aquatic disinfectant containing block copolymer complexed iodine according to claim 1, characterized in that: The co-solvent is any one of sorbitol, glycerol, ethanol, ethylene glycol, and propylene glycol.

6. A method for preparing an aquatic disinfectant containing block copolymer complexed iodine according to any one of claims 1-4, characterized in that: Includes the following steps: (1) Add surfactant carrier and elemental iodine to the reaction apparatus in sequence, turn on the stirring, and stir for 2-3 hours at 40℃-50℃ until the iodine is completely dissolved. (2) After adding the stabilizer, stir for 1-2 hours to dissolve and dilute the acid, then add it to the reaction device and make up the remaining water to obtain aquatic disinfectant containing block copolymer complexed iodine.

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