A composition for promoting infiltration of local anesthesia and a preparation method and application thereof

By using a specific ratio of lidocaine, prilocaine, menthol, and laurocapram, a local anesthetic composition was prepared, which solved the problem of long anesthetic onset time in the prior art and achieved rapid drug efficacy and good stability of local anesthetic effect.

CN117919214BActive Publication Date: 2026-07-24SUZHOU GAOMAI PHARM CO LTD
View PDF 2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU GAOMAI PHARM CO LTD
Filing Date
2023-12-27
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing local anesthetics such as EMLA have a long anesthetic onset time, resulting in long waiting times for patients. Furthermore, the penetration performance and duration of action of traditional topical preparations are affected by the type and dosage of active ingredients and penetration enhancers, leading to unstable onset time and intensity of action.

Method used

Lidocaine and prilocaine are used as active ingredients, combined with menthol and laurocapram as penetration enhancers, and local anesthetic compositions are prepared by mixing them in a specific ratio. Emulsifiers, gelling agents and pH adjusters are added to form eutectic mixtures and emulsions to promote drug penetration.

Benefits of technology

It achieves rapid local anesthetic effect, reduces patient waiting time, and the composition has good stability, making it suitable for industrial production. It also improves transdermal absorption rate and prolongs duration of effect.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure BDA0004636068560000081
    Figure BDA0004636068560000081
  • Figure BDA0004636068560000101
    Figure BDA0004636068560000101
  • Figure BDA0004636068560000102
    Figure BDA0004636068560000102
Patent Text Reader

Abstract

The application belongs to the technical field of pharmaceutical preparations, and relates to a local anesthetic composition for promoting penetration, a preparation method and application thereof. The local anesthetic composition comprises: an active ingredient and a penetration enhancer; the active ingredient is lidocaine and prilocaine; the penetration enhancer is at least one of menthol and laurocapram; and the mass ratio of the active ingredient and the penetration enhancer is 0.7-6.8:1. The application is compounded with menthol and laurocapram at a specific mass ratio, synergistically promotes the penetration of the active ingredient, and further quickly exerts the local anesthetic effect. Further, the specific mass ratio of menthol, laurocapram and the active ingredient further promotes the penetration of the drug and reduces the waiting time of patients. The application is subjected to strict formula and process research, and on the basis of ensuring the fast local anesthetic effect, the product quality is stable, and the needs of industrial production can be met.
Need to check novelty before this filing date? Find Prior Art