Bactericidal compositions and their use

Abstract

The present application belongs to the field of agricultural fungicides, and particularly relates to a fungicidal composition and application thereof.The composition comprises two active components A and B, the weight ratio of the active component A to the active component B is 1:99-99:1; the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof, and the active component B is selected from one fungicide.The fungicidal composition is particularly suitable for preventing and treating various plant pathogenic fungi and bacterial diseases.

Description

[0001] This application is a further divisional application of Chinese Invention Patent 202011314120.0, specifically divisional application 2022105532428. Chinese Invention Patent 202011314120.0 was filed on November 20, 2020, with the invention title "Bactericidal Composition and Its Application," publication number CN112825859A, and Chinese Invention Patent 202210553242.8 publication number CN114903046A. Due to the unity of invention issue pointed out by the examiner in Chinese Invention Patent 202210553242.8, the applicant has filed this divisional application again. Technical Field

[0002] This invention belongs to the field of agricultural fungicides, specifically relating to a fungicidal composition of a pyrimidine-containing substituted pyrazole compound and a fungicide, and its application. Background Technology

[0003] Patent WO2016184378 discloses a pyrimidine-containing substituted pyrazole compound and its uses, in which compounds represented by the following general formulas IA and IB are reported to have good activity against a variety of diseases.

[0004]

[0005] Respiratory inhibitors, nucleic acid metabolism inhibitors, cell wall synthesis inhibitors, signal transduction inhibitors, cytoskeleton and motor protein inhibitors, sterol biosynthesis inhibitors, phospholipid synthesis inhibitors, and methionine biosynthesis inhibitors are widely used and highly effective fungicides in agricultural production. However, due to their single site of action, the field efficacy of some varieties significantly decreases after long-term repeated use. Multi-site inhibitors are a class of broad-spectrum protective fungicides, but they have poor curative activity and require large field application rates.

[0006] In the practice of fungicide application, it is often observed that a pesticide initially exhibits excellent disease prevention effects, but with repeated use and gradually increasing dosage, the efficacy improves only slightly, and sometimes it even loses its preventative effect entirely. The main reason for this is a change in the pathogen population; some pathogens acquire resistance plasmids through mutation, leading to resistance, which gradually forms a dominant population through natural selection, resulting in reduced fungicide efficacy. Simultaneously, it is recognized that after pesticide application, some residues remain on the soil, escape into the air, or flow into rivers and lakes with rainwater and farmland drainage, causing environmental pollution. Therefore, there is an urgent need for pesticide products that are highly effective, require small dosages, cause minimal environmental pollution, and can delay the development of pathogen resistance.

[0007] Combination application of pesticides is an important means to delay the development of pesticide resistance in pathogens and an effective method to reduce pesticide dosage. The scientific validity of fungicide combination application depends not only on the target pests and their mechanisms of action, but also on the combined effects of the mixed agents. Therefore, developing a highly effective fungicide combination with complementary and significant synergistic effects faces many constraints and has an extremely low success rate. Summary of the Invention

[0008] The present invention aims to provide a synergistic bactericidal composition of a pyrimidine-containing substituted pyrazole compound and a bactericide, and its use therein.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A bactericidal composition comprising two active components, A and B, wherein the weight ratio of active component A to active component B is 1:99-99:1.

[0011] Among them, active component A is one or more of pyrimidine-containing substituted pyrazole compounds or their salts; active component B is selected from a bactericide.

[0012] Active component A is a compound or its salt represented by general formula IA or IB:

[0013]

[0014] In the formula:

[0015] R1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C1-C4 alkylthio, halo-C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C4 alkenyl, halo-C2-C4 alkenyl, C2-C4 alkynyl, and halo-C2-C4 alkynyl. C3-C4 alkenoxy, halogenated C3-C4 alkenoxy, C3-C4 alkynoxy, halogenated C3-C4 alkynoxy, C1-C4 alkylamino, di(C1-C4 alkyl)amino, C1-C4 alkylaminocarbonyl, halogenated C1-C4 alkylaminocarbonyl, C1-C4 alkoxycarbonyl, halogenated C1-C4 alkoxycarbonyl, C1-C4 alkoxyC1-C4 alkyl or C1-C4 alkylthioC1-C4 alkyl;

[0016] R2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy;

[0017] R3 is selected from hydrogen, hydroxyl, formyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halogenated C2-C4 alkenyl, halogenated C2-C4 alkynyl, C1-C4 alkoxy-C1-C4 alkyl, halogenated C1-C4 alkoxy-C1-C 4-alkyl, C1-C4 alkylthioC1-C4 alkyl, halo-C1-C4 alkylthioC1-C4 alkyl, C1-C4 alkylsulfinyl, halo-C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, halo-C1-C4 alkylsulfonyl, C1-C4 alkylaminosulfonyl, di(C1-C4 alkyl)aminosulfonyl, C1-C4 alkylsulfonylaminocarbonyl, C1-C4 alkylcarbonylaminosulfonyl C3-C4 cycloalkyloxycarbonyl, C1-C4 alkylcarbonyl, halo-C1-C4 alkylcarbonyl, C1-C4 alkoxycarbonyl, halo-C1-C4 alkoxycarbonyl, C1-C4 alkylcarbonyl, C1-C4 alkyl, C1-C4 alkoxycarbonyl, C1-C4 alkylaminocarbonyl, di(C1-C4 alkyl)aminocarbonyl, C2-C4 alkenoxycarbonyl, C2-C4 alkynoxycarbonyl C1-C4 alkoxy C1-C4 alkoxy carbonyl, C1-C4 alkyl aminothio, di(C1-C4 alkyl)aminothio, aryl carbonyl C1-C4 alkyl, aryl carbonyl, aryloxy carbonyl, aryl C1-C4 alkyloxy carbonyl, aryl C1-C4 alkyl, heteroaryl carbonyl C1-C4 alkyl, heteroaryl carbonyl, heteroaryloxy carbonyl, heteroaryl C1-C4 alkyloxy carbonyl or heteroaryl C1-C4 alkyl;

[0018] R4 and R5 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy respectively; wherein, R4, R5 and the C attached to them may also form a C3-C4 ring.

[0019] R6 and R7 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy respectively; wherein, R6, R7 and the C attached to them may also form a C3-C4 ring.

[0020] R8 and R9 may be the same or different, and are selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl, halo-C1-C4 alkoxycarbonyl, unsubstituted or with 1-5 Rs. 11 Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;

[0021] R11 Selected from halogens, hydroxyl groups, amino groups, cyano groups, nitro groups, C1-C4 alkyl groups, halogenated C1-C4 alkyl groups, C1-C4 alkoxy groups, halogenated C1-C4 alkoxy groups, C3-C4 cycloalkyl groups, C1-C4 alkylamino groups, halogenated C1-C4 alkylamino groups, di(C1-C4 alkyl)amino groups, halogenated di(C1-C4 alkyl)amino groups, C1-C4 alkylthio groups, halogenated C1-C4 alkylthio groups, C2-C4 alkenyl groups, C2-C4 alkynyl groups, C2-C4 alkenyloxy groups, halogenated C2-C4 alkenyloxy groups, C2-C4 alkoxy groups, halogenated C2-C4 alkoxy carbonyl groups, C1-C4 alkyl sulfonyl groups, halogenated C1-C4 alkyl sulfonyl groups, C1-C4 alkyl carbonyl groups, halogenated C1-C4 alkyl carbonyl groups, C1-C4 alkoxy carbonyl groups, halogenated C1-C4 alkoxy carbonyl groups, C1-C4 alkoxy C1 -C4 alkyl, halo-C1-C4 alkoxy-C1-C4 alkyl, C1-C4 alkylthio-C1-C4 alkyl, halo-C1-C4 alkylthio-C1-C4 alkyl, C1-C4 alkoxycarbonyl-C1-C4 alkyl, halo-C1-C4 alkoxycarbonyl-C1-C4 alkyl, halo-C1-C4 alkylthiocarbonyl-C1-C4 alkyl, C1-C4 alkylcarbonyloxy, halo-C1-C4 alkylcarbonyloxy, C1-C4 alkoxycarbonyloxy, halo-C1-C4 alkoxycarbonyloxy, C1-C4 alkylsulfonyloxy, halo-C1-C4 alkylsulfonyloxy, C1-C4 alkoxy-C1-C4 alkoxy or halo-C1-C4 alkoxy-C1-C4 alkoxy; n is selected from integers from 0 to 5, when n is greater than 1, R 11 They can be the same or different;

[0022] R 14 R 15 R 16 or R 17 They may be the same or different, and are selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, or C3-C4 cycloalkyl;

[0023] W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy, C1-C4 alkylthio or C1-C4 alkylsulfonyl;

[0024] The salts of the pyrimidine-containing substituted pyrazole compounds are salts formed by the compounds represented by general formula IA or IB with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid, or citric acid.

[0025] Active component B is selected from one or more of the following: respiratory inhibitor bactericides, nucleic acid metabolism inhibitor bactericides, cell wall synthesis inhibitor bactericides, signal transduction inhibitor bactericides, cytoskeleton and motor protein inhibitor bactericides, sterol biosynthesis inhibitor bactericides, phospholipid synthesis inhibitor bactericides, methionine biosynthesis inhibitor bactericides, multi-site inhibitor bactericides, and bactericides with unknown mechanisms of action.

[0026] When active component A is a compound of general formula IA or a salt thereof, preferably, the composition is active component A and active component B in a weight ratio of 1:50-50:1;

[0027] Wherein, active component A is selected from one or more of the compounds of general formula IA or their salts;

[0028] In the formula: R3 is selected from hydrogen, hydroxyl, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halo-C2-C4 alkenyl, or halo-C2-C4 alkynyl; R4 and R5 may be the same or different, and are respectively selected from hydrogen, halogen, C1-C4 alkyl, halo-C1 -C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy; R6 and R7 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy, respectively; R8 and R9 may be the same or different, and are selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl, or halo-C1-C4 alkoxycarbonyl, respectively; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylamino, halo-C1-C4 alkylamino, di(C1-C4 alkyl)amino, halo-di(C1-C4 alkyl)amino, or C1-C4 alkylthio; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They can be the same or different; R 14 R 15 R 16 or R 17 They may be the same or different, and are selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl or C1-C4 alkoxy; W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy or C1-C4 alkylthio;

[0029] The salts of the compounds represented by general formula IA are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, or maleic acid.

[0030] Active component B is selected from the following: flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B45, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, flusulfamide B50, tiadinil B51, ethaboxam B52, cyflufenamid B53, fenhexamid B54, diclocymet B55, bupirimate B56, and dimethirimol. B57, Ethirimol; B58, Hymexazol; B59, Octilinone; B60, Ofurace; B61, Chinomethionat; B62, Metidaxyl; B63, Furalaxyl; B64, Fludioxonil; B65, Fenpicloni; B66, Iprodione; B67, Procymidone; B68, Meclozolin; B69, Chlozolinate; B70, Dimethachlon; B71, Vinclozolin; B72, Diethofencarb; B73, Metrafenone; B74, PyriofenoneB75, Carbendazim; B76, Thiophanate-methyl; B77, Phenamacril; B78, Benomyl; B79, Fuberidazole; B80, Thiabendazole; B81, Thiophanate; B82, Pencycuron; B83, Etaconazole; B84, Ethanone; B85, Fenarimol; B86, Fenbuconazole; B87, Fenpropidine; B88, Fenpropimorph; B89, Fenpyrazamine; B90, Mefe-Flavorosilazole. ntrifluconazole B91, nuarimol B92, oxpoconazole B93, pefurazoate B94, prochloraz B95, spiroxamine B96, pyrisoxazole B97, tridemorph B98, triforine B99, dodemorph B100, bromuconazole B101, triapenthenol B102, naftifine B103, simeconazole B104, triflumizole B105, ipfentrifluconazole B106, Tetrachloronitrobenzene; B107, Chloroneb; B108, Dicloran; B109, Biphenyl; B110, Edifenphos; B111, Etridiazole; B112, Iodocarb; B113, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, FluoxapiprolineB117, propamocarb; B118, prothiocarb; B119, pyrazophos; B120, quintozene; B121, tolclofos-methyl; B122, benthiavalicarb-isopropyl; B123, polyoxin; B124, valifenalate; B125, pyrimorph; B12 6. Blasicidin-S B127. Cyprodinil B128. Kasugamycin B129. Mepanipyrim B130. Pyrimethanil B131. Streptomycin B132. Oxytetracycline B133. Zineb B134. Mancozeb B135. Metiram B136. Propineb propineb B137, mancozeb B138, amobam B139, sodium mancozeb B140, etem B141, milneb B142, mancopper B143, cufraneb B144, sulfur B145, anilazine B146, captan B147, chinomethionat B148, chlorothalonil othalonil (B149), dichlofluanid (B150), tolylfluanid (B151), dithianon (B152), fluoroimide (B153), methasulfocarb (B154), captafol (B155), folpet (B156), iminoctadine (B157), guazatine (B158), zinc thiazole (B159), oxine-copper (B160), thiodiazole-copper (B161), cuppric nonyl phenolsulfonate (B162), picarbutrazox (B163), aminopyrifenOne or more of the following: B164, metyltetraprole, dodine, pyridachlometyl, diclomezine, validamycin, ferimzone, tebufloquin, triazine, quinofumelin, ipflufenoquin, dipymetitrone, and teclofthalam.

[0031] More preferably, the composition comprises active component A and active component B in a weight ratio of 1:20 to 20:1;

[0032] Wherein, active component A is one or more of the compounds represented by general formula IA or their salts;

[0033] In the formula, R3 is selected from hydrogen, hydroxyl, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halo-C2-C4 alkenyl, or halo-C2-C4 alkynyl; R4 and R5 may be the same or different, and are respectively selected from hydrogen, halogen, C1-C4 alkyl, halo-C1 -C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy; R6 and R7 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy, respectively; R8 and R9 may be the same or different, and are selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl, or halo-C1-C4 alkoxycarbonyl, respectively; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylamino, or halo-C1-C4 alkylamino; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They can be the same or different; R 14 R 15 R 16 or R 17They may be the same or different, and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy or halo-C1-C4 alkoxy; W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy or C1-C4 alkylthio;

[0034] The salts of the compounds represented by general formula IA are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, or methanesulfonic acid.

[0035] Active component B is selected from the following: flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, benalaxyl-M B49, tiadinil B51, ethaboxam B52, bupirimate B56, dimethirimol B57, and ethi... rimol B58, hymexazol B59, octhilinone B60, ofuronamide B61, chinomethionat B62, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenone B75, Carbendazim; B76, Thiophanate-methyl; B77, Phenamacril; B78, Benomyl; B79, Ethanone; B85, Fenarimol; B86, Fenbuconazole; B87, Fenpropidine; B88, Fenpyrazamine; B90, Mefentrifluconazole; B91, Nuarimol; B92, Oxpoconazole; B93, Pefurazoate; B94, Prochloraz; B95, Spiroxamine; B96, Pyrisoxazole; B97, Simeconazole; B104, IpfentrifluconazoleB106, Eifenphos; B111, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, Fluoxapiproline B117, propamocarb; B118, prothiocarb; B119, pyrazophos; B120, quintozene; B121, tolclofos-methyl; B122, benthiavalicarb-isopropyl; B123, polyoxin; B124, valifenalate; B125, pyrimorph; B126, cyprodinil; B128, kasugamycin; B129, mepanipyrim; B130, pyrimethanil; B131, streptomycin; B132, [unclear text - possibly a typo, should be removed]. Zinc (Zineb) B134, Mancozeb (Mancozeb) B135, Metiram (Metiram) B136, Propineb (Propineb) B137, Mancozeb (Mancozeb) B138, Amobam (Amobam) B139, Milneb (Mirneb) B142, Mancopper (Mancopper) B143, Sulfur (Sulphur) B145, Anilazine (Anilazine) B146, Captan (Captan) B147, Chlorothalonil (Chlorothalonil) B149, Dichlofluanid (Sulphur) B150, Tolylfluanid (Tolylfluanid) B151, Methasulfocarb (Methasulfuron) B154, Captafol (Captafol) B155, Folpet (Folpet) B156, Zinc (Thiamethoxam) Thiazole (B159), oxine-copper (B160), thiodiazole-copper (B161), cuppric nonylphenolsulfonate (B162), picarbutrazox (B163), aminopyrifen (B164), metyltetraprole (B165), pyridachlometyl (B167), validamycin (B169), ferimzone (B170), tebufloquinOne or more of the following: B171, quinofumelin, B173, ipflufenoquin, B174, dipymetitrone, B175, teclofthalam, and B176.

[0036] More preferably, the composition comprises active component A and active component B in a weight ratio of 1:10 to 10:1;

[0037] Wherein, active component A is selected from one or more of the compounds of general formula IA or their salts;

[0038] In the formula, R3 is selected from hydrogen, hydroxyl, formyl, or C1-C4 alkyl; R4 and R5 may be the same or different, and are respectively selected from hydrogen, halogen, or C1-C4 alkyl; R6 and R7 may be the same or different, and are respectively selected from hydrogen, halogen, or C1-C4 alkyl; R8 and R9 may be the same or different, and are respectively selected from hydrogen, cyano, halogen, or C1-C4 alkyl; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, or C1-C4 alkyl; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They can be the same or different; R 14 R 15 R 16 or R 17 They may be the same or different, and are selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro or C1-C4 alkyl; W is selected from hydrogen, halogen or C1-C4 alkyl;

[0039] The salts of the compounds represented by general formula IA are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;

[0040] Active component B is selected from flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil B48, tiadinil B51, ethaboxam B52, and bupirifensulfonate. mate)B56, ethirimol B58, hymexazol B59, octhilinone B60, chinomethionat B62, fludioxonil B65, iprodione B67, procymidone B68, diethofencarb B73, metrafenone B74, pyriofenone B75, Carbendazim; B76, Thiophanate-methyl; B77, Phenamacril; B78, Fenbuconazole; B87, Mefentrifluconazole; B91, Nuarimol; B92, Prochloraz; B95, Spiroxamine; B96, Pyrisoxazole; B97, Simeconazole; B104, IpfentrifluconazoleB106, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, Fluoxapiproline; B117, Propamocarb; B118, Quintozene; B121, Tolclofos-methyl; B122, Benthiavalicarb-isopropyl; B123, Polyoxin; B124, Valifenalate; B125, Pyrimorph; B126, Cyprodinil; B128, Kasugamycin; B129. Pyrimethanil B131, Streptomycin B132, Zineb B134, Mancozeb B135, Metiram B136, Propineb B137, Sulfur B145, Captan B147, Chlorothalonil B149, Dichlofluanid B150, Captafol B155, Folpet B156, Zincthiazole B159, Oxine-copper B160, Thiodiazole-copper B161, Cuppric One or more of the following: nonyl phenolsulfonate B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipymetitrone B175, and teclofthalam B176.

[0041] When active component A is a compound of general formula IB or a salt thereof, preferably, the composition is active component A and active component B in a weight ratio of 1:50-50:1;

[0042] Wherein, active component A is selected from one or more compounds of general formula IB or their salts;

[0043] In the formula, R1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C1-C4 alkylthio, halo-C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C2-C4 alkenyl, halo-C2-C4 alkenyl, C2-C4 ynyl or halo-C2-C4 ynyl; R2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4 alkyl or halo-C1-C4 alkyl; R3 is selected from hydrogen, hydroxyl, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3 -C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halo-C2-C4 alkenyl, or halo-C2-C4 alkynyl; R4 and R5 may be the same or different, and are respectively selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy; R6 and R7 may be the same or different, and are respectively selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy; R8 and R9 may be the same or different, and are respectively selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl, or halo-C1-C4 alkoxycarbonyl; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylamino, halo-C1-C4 alkylamino, di(C1-C4 alkyl)amino, halo-di(C1-C4 alkyl)amino, or C1-C4 alkylthio; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They may be the same or different; W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy or C1-C4 alkylthio;

[0044] The salts of the compounds represented by general formula IB are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, or maleic acid.

[0045] Active component B is selected from the following: dinocap B40, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, metalaxyl B45, metalaxyl-M B46, iprovalicarb B47, and cymoxanil. B48, Benalaxyl-M; B49, Flusulfamide; B50, Tiadinil; B51, Ethaboxam; B52, Cyflufenamid; B53, Fenhexamid; B54, Dicloymet; B55, Bupirimate; B56, Dimethoprim. thirimol B57, ethirimol B58, hymexazol B59, octhilinone B60, ofuronamide B61, chinomethionat B62, metidaxyl B63, furaxyl B64, fludioxonil B65, fenpicloni B66, iprodione B67, procymidone B68, meclozolin B69, chlozolinate B70, dimethachlon B71, vinclozolin B72, diethofencarb B73, metrafenone B74, pyriofenoneB75, Carbendazim; B76, Thiophanate-methyl; B77, Phenamacril; B78, Benomyl; B79, Fuberidazole; B80, Thiabendazole; B81, Thiophanate; B82, Pencycuron; B83, Etaconazole; B84, Ethanone; B85, Fenarimol; B86, Fenbuconazole; B87, Fenpropidine; B88, Fenpropimorph; B89, Fenpyrazamine; B90, Mefe-Flavorosilazole. ntrifluconazole B91, nuarimol B92, oxpoconazole B93, pefurazoate B94, prochloraz B95, spiroxamine B96, pyrisoxazole B97, tridemorph B98, triforine B99, dodemorph B100, bromuconazole B101, triapenthenol B102, naftifine B103, simeconazole B104, triflumizole B105, ipfentrifluconazole B106, Tetrachloronitrobenzene; B107, Chloroneb; B108, Dicloran; B109, Biphenyl; B110, Edifenphos; B111, Etridiazole; B112, Iodocarb; B113, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, FluoxapiprolineB117, propamocarb; B118, prothiocarb; B119, pyrazophos; B120, quintozene; B121, tolclofos-methyl; B122, benthiavalicarb-isopropyl; B123, polyoxin; B124, valifenalate; B125, pyrimorph; B12 6. Blasicidin-S B127. Cyprodinil B128. Kasugamycin B129. Mepanipyrim B130. Pyrimethanil B131. Streptomycin B132. Oxytetracycline B133. Zineb B134. Mancozeb B135. Metiram B136. Propineb propineb B137, mancozeb B138, amobam B139, sodium mancozeb B140, etem B141, milneb B142, mancopper B143, cufraneb B144, sulfur B145, anilazine B146, captan B147, chinomethionat B148, chlorothalonil othalonil (B149), dichlofluanid (B150), tolylfluanid (B151), dithianon (B152), fluoroimide (B153), methasulfocarb (B154), captafol (B155), folpet (B156), iminoctadine (B157), guazatine (B158), zinc thiazole (B159), oxine-copper (B160), thiodiazole-copper (B161), cuppric nonyl phenolsulfonate (B162), picarbutrazox (B163), aminopyrifenOne or more of the following: B164, metyltetraprole, dodine, pyridachlometyl, diclomezine, validamycin, ferimzone, tebufloquin, triazine, quinofumelin, ipflufenoquin, dipymetitrone, and teclofthalam.

[0046] More preferably, the composition comprises active component A and active component B in a weight ratio of 1:20 to 20:1;

[0047] Wherein, active component A is selected from one or more compounds of general formula IB or their salts;

[0048] In the formula, R1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, or halo-C1-C4 alkyl; R2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4 alkyl, or halo-C1-C4 alkyl; R3 is selected from hydrogen, hydroxyl, formyl, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylthio, C2-C4 alkenylthio, C2-C4 alkenyl, C2-C4 alkynyl, halo-C2-C4 alkenyl, or halo-C2-C4 alkenyl. C2-C4 alkynyl; R4 and R5 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy, respectively; R6 and R7 may be the same or different, and are selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, or halo-C1-C4 alkoxy, respectively; R8 and R9 may be the same or different, and are selected from hydrogen, cyano, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxycarbonyl, or halo-C1-C4 alkoxycarbonyl, respectively; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, C1-C4 alkyl, halo-C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C4 alkoxy, C3-C4 cycloalkyl, C1-C4 alkylamino, or halo-C1-C4 alkylamino; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They may be the same or different; W is selected from hydrogen, halogen, C1-C4 alkyl, halo-C1-C4 alkyl, C3-C4 cycloalkyl, C1-C4 alkoxy or C1-C4 alkylthio;

[0049] The salts of the compounds represented by general formula IB are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, or methanesulfonic acid.

[0050] Active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, and boscal. B9, Bixafen, Flutolanil, Furametpyr, Thifluzamide, Pydiflumetofen, Fluindapyr, Fluopimomide, Isofetamid, Inpyrfluxam B18, isoflucypram; B19, pyraziflumid; B20, pyrapropoyne; B21, benodanil; B26, fluopicolide; B27, fenamidone; B28, famoxadone; B29, cyazofamid; B30, ametoctradin; B31, fluazinam; B32, fenpicoxamid; B33, florylpicoxamidB34, Amisulbrom; B35, Silthiopham; B36, Pyribencarb; B37, Flumorph; B41, Dimethomorph; B42, Mandipropamid; B43, Zoxamide; B44, Metalaxyl-M; B46, Iprovalicarb; B47, Cymoxanil; B48, Benalaxyl-M; B49, Tiadin B51, Ethaboxam, Bupirimate, Dimethirimol, Ethirimol, Hymexazol, Octhilinone, Ofuronide, Chinomethionat, Fludioxonil, Fenpicloni, Iprodione, Procymidone Dimethachlon (B71), Vinclozolin (B72), Dietofencarb (B73), Metrafenone (B74), Pyriofenone (B75), Carbendazim (B76), Thiophanate-methyl (B77), Phenamacril (B78), Benomyl (B79), Ethanone (B85), Fenarimol (B86), Fenbuconazole B87, fenpropidine; B88, fenpyrazamine; B90, mefentrifluconazole; B91, nuarimol; B92, oxpoconazole; B93, pefurazoate; B94, prochloraz; B95, spiroxamine; B96, pyrisoxazole; B97, simeconazole; B104, ipfentrifluconazoleB106, Eifenphos; B111, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, Fluoxapiproline; B117, Propamocarb; B118, Prothiocarb; B119, Pyrazophos; B120, Quinoline. tozene (B121), methyl tolclofos-methyl (B122), benthiavalicarb-isopropyl (B123), polyoxin (B124), valifenalate (B125), pyrimorph (B126), cyprodinil (B128), kasugamycin (B129), mepani (B129) Pyrim (B130), Pyrimethanil (B131), Streptomycin (B132), Zineb (B134), Mancozeb (B135), Metiram (B136), Propineb (B137), Mancozeb (B138), Amobam (B139), Milneb (B142), Mancopper (B143) Sulfur (B145), Anilazine (B146), Captan (B147), Chlorothalonil (B149), Dichlofluanid (B150), Tolylfluanid (B151), Methasulfocarb (B154), Captafol (B155), Folpet (B156), Zinc thiamethoxam Thiazole (B159), oxine-copper (B160), thiodiazole-copper (B161), cupric nonyl phenolsulfonate (B162), picarbutrazox (B163), aminopyrifen (B164), metyltetraprole (B165), pyridachlometyl (B167), validamycin (B169), ferimzone (B170), tebufloquinOne or more of the following: B171, quinofumelin, B173, ipflufenoquin, B174, dipymetitrone, B175, teclofthalam, and B176.

[0051] More preferably, the composition comprises active component A and active component B in a weight ratio of 1:10 to 10:1;

[0052] Wherein, active component A is selected from one or more compounds of general formula IB or their salts;

[0053] In the formula, R1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, or C1-C4 alkyl; R2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, or C1-C4 alkyl; R3 is selected from hydrogen, hydroxyl, formyl, or C1-C4 alkyl; R4 and R5 may be the same or different, and are respectively selected from hydrogen, halogen, or C1-C4 alkyl; R6 and R7 may be the same or different, and are respectively selected from hydrogen, halogen, or C1-C4 alkyl; R8 and R9 may be the same or different, and are respectively selected from hydrogen, cyano, halogen, or C1-C4 alkyl; R 11 Selected from halogen, hydroxyl, amino, cyano, nitro, or C1-C4 alkyl; n is selected from an integer from 0 to 5. When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 They may be the same or different; W is selected from hydrogen, halogen or C1-C4 alkyl;

[0054] The salts of the compounds represented by general formula IB are salts formed by the general formula compound with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;

[0055] Active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluopimomide B16, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, and pyrapropoyne. B21, benodanil; B26, fluopicolide; B27, fenamidone; B28, famoxadone; B29, cyazofamid; B30, ametoctradin; B31, fluazinam; B32, fenpicoxamid; B33, florylpicoxamid B34, silthiopham; B36, flumorph; B41, dimethomorph; B42, mandipropamid; B43, zoxamide; B44, metalaxyl-M; B46, iprovalicarb; B47, cymoxanil; B48, tiadinil; B51, ethaboxam; B52, ethirimol sulfadiazine. Bupirimate (B56), Ethirimol (B58), Hymexazol (B59), Octilinone (B60), Chinomethionat (B62), Fludioxonil (B65), Iprodione (B67), Procymidone (B68), Dietofencarb (B73), Metrafenone (B74), PyriofenoneB75, Carbendazim; B76, Thiophanate-methyl; B77, Phenamacril; B78, Fenbuconazole; B87, Mefentrifluconazole; B91, Nuarimol; B92, Prochloraz; B95, Spiroxamine; B96, Pyrisoxazole; B97, Simeconazole; B104, Ipfentrifluconazole B106, Iprobenfos; B114, Isoprothiolane; B115, Oxathiapiprolin; B116, Fluoxapiproline; B117, Propamocarb; B118, Quintozene; B121, Tolclofos-methyl; B122, Benthiavalicarb-isopropyl; B123, Polyoxin; B124, Valifenalate; B125, Pyrimorph; B126, Cyprodinil; B128, Kasugamycin; B129, Pyrimethanil. Pyrimethanil B131, Streptomycin B132, Zineb B134, Mancozeb B135, Metiram B136, Propineb B137, Sulfur B145, Captan B147, Chlorothalonil B149, Dichlofluanid B150, Captafol B155, Folpet B156, Zincthiazole B159, Oxine-copper B160, Thiodiazole-copper B161, Copper N-methyl nonyl phenolsulfonate)B162, picarbutrazox B163, aminopyrifen B164, metyltetraprole B165, pyridachlometylOne or more of the following: B167, validamycin, B169, tebufloquin, B171, quinofumelin, B173, ipflufenoquin, B174, dipymetitrone, B175, and teclofthalam.

[0056] Application of a bactericidal composition, wherein the bactericidal composition is used to prepare a drug for controlling plant pathogenic fungal and bacterial diseases.

[0057] The plant pathogenic fungal and bacterial diseases mentioned are: powdery mildew, rust, black spot, leaf mold, sheath blight, damping-off, black spot, smut, smut, downy mildew, late blight, blight, downy mildew, black shank, cottony rot, damping-off, cottony blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, vine blight, gray mold, sclerotinia rot, rot, root rot, Fusarium head blight, soft rot, white leaf blight, leaf blight, angular leaf spot, circular leaf spot, white leaf blight, bacterial wilt, canker, or Huanglongbing.

[0058] A bactericidal preparation, wherein the active ingredient of the preparation is the bactericidal composition, and the bactericidal composition has a weight percentage of 0.1-95%.

[0059] Depending on the severity of crop diseases, the concentration of the composition of the present invention used in the crop planting area is 5-500 mg / L (active ingredient content, the same below), preferably 50-200 mg / L.

[0060] In the composition of the present invention, active component A and at least one active component B are prepared in advance or prepared on-site according to the appropriate ratio provided by the present invention, or the two components are used separately and sequentially.

[0061] The composition of this invention is suitable for the prevention and control of fungal and bacterial diseases in trees (apple, rubber, pear, citrus, hawthorn, chestnut, Sichuan pepper, wolfberry, mango, papaya, lychee, banana, peach, etc.), vines (grapes, etc.), melons and vegetables (tomato, eggplant, pepper, cucumber, cantaloupe, winter melon, watermelon, pumpkin, bitter melon, loofah, chayote, bottle gourd, zucchini, lettuce, potato, carrot), legumes (pea, green bean, cowpea), cereals (wheat, rice, corn, sorghum, etc.), oil crops (rapeseed, soybean, peanut, sesame, etc.), alliums (scallion, garlic, onion), cash crops (tobacco, etc.), flowering plants and lawns, as well as for seed treatment and fruit preservation.

[0062] The bactericidal composition of this invention is particularly suitable for controlling the following plant diseases: powdery mildew of apple trees, rubber trees, citrus trees, hawthorn trees, chestnut trees, Sichuan pepper trees, wolfberries, mango trees, papaya trees, corn trees, grape trees, tomatoes, eggplant trees, pepper trees, cucumber trees, cantaloupes, winter melon trees, watermelons, pumpkin trees, bitter melon trees, loofah trees, chayote trees, bottle gourd trees, zucchini trees, lettuce trees, and pea trees. Powdery mildew of beans, wheat, barley, roses, chrysanthemums, turfgrass, carrots, apple trees, pear trees, soybeans, peas, beans, cowpeas, wheat, barley, corn, onions, garlic, and turfgrass; anthracnose of apple trees, rubber trees, pear trees, citrus, hawthorn, chestnuts, Sichuan pepper, wolfberries, mangoes, papayas, and hazelnuts. Anthracnose, grape anthracnose, tomato anthracnose, eggplant anthracnose, pepper anthracnose, melon anthracnose, winter melon anthracnose, watermelon anthracnose, pumpkin anthracnose, bitter melon anthracnose, loofah anthracnose, chayote anthracnose, bottle gourd anthracnose, zucchini anthracnose, lettuce anthracnose, cucumber downy mildew, grape downy mildew, melon downy mildew, bitter melon downy mildew, loofah downy mildew, tomato late blight, potato late blight, pepper blight, cucumber damping-off, eggplant damping-off, pepper damping-off, pear brown spot, cucumber brown spot, pear black spot, rose black spot, rose Black spot, chrysanthemum black spot, soybean brown spot, cowpea red spot, apple leaf spot, common bean ring spot, eggplant leaf spot, potato black scurf, wheat sheath blight, rice sheath blight, rice bakanae disease, soybean damping-off, pea damping-off, common bean damping-off, onion damping-off, garlic damping-off, onion damping-off, turfgrass damping-off, citrus canker, citrus Huanglongbing, rice bacterial leaf blight, rice bacterial stripe, tomato bacterial wilt, cucumber bacterial angular leaf spot, and gray mold and sclerotinia rot caused by pathogens of the genera *Botrytis* and *Sclerotinia*.

[0063] Advantages of this invention:

[0064] This invention combines active component A and fungicide active component B in different proportions. The "observed efficacy" is greater than the "calculated efficacy," demonstrating a significant synergistic effect. This reduces the dosage of the pesticide and minimizes environmental pollution. Furthermore, this invention uses a mixture of fungicides with different mechanisms of action, which helps delay the development of resistance in pathogens. This provides an effective solution to the fungicide resistance problem faced by agricultural production and the pesticide industry, extending the lifespan of the pesticide. Detailed Implementation

[0065] The synergistic effect of the composition of the present invention against harmful fungi and bacterial diseases can be further illustrated by the following examples, but the present invention is by no means limited thereto. The active components mentioned therein are compound A and fungicide B in the bactericidal composition of the present invention;

[0066] The preparation of compound A is described in WO2016184378. Bactericide B is selected from one or more of the following: respiratory inhibitors, nucleic acid metabolism inhibitors, cell wall synthesis inhibitors, signal transduction inhibitors, cytoskeleton and motor protein inhibitors, sterol biosynthesis inhibitors, phospholipid synthesis inhibitors, cell wall synthesis inhibitors, methionine biosynthesis inhibitors, multisite inhibitors, and bactericides with unknown mechanisms of action.

[0067] The testing and evaluation methods are as follows:

[0068] The active samples to be tested are active component A, active component B, and a combination of active component A and active component B.

[0069] The active component A is one or more of active components A1, A2, A3 and A4;

[0070] Among them, the active component A1 is compound A1 represented by general formula IA;

[0071] Active component A2 is a salt formed by compound A1 and sulfuric acid;

[0072] Compound A1 is

[0073]

[0074] In the formula, R3 is selected from hydrogen, R4 and R5 are selected from hydrogen, R6 and R7 are selected from hydrogen, R8 and R9 are selected from hydrogen, and R 11 Selected from 4-chloro, n=1, R 14 R 15 R 16 or R 17 Both are selected from hydrogen, and W is selected from hydrogen, which is compound A1;

[0075] Active component A3 is compound A3 represented by general formula IB;

[0076] Active component A4 is a salt formed by compound A3 and sulfuric acid:

[0077] Compound A3 is

[0078]

[0079] In the formula:

[0080] R3 is selected from hydrogen, R4 and R5 are each selected from hydrogen, R6 and R7 are each selected from hydrogen, R8 and R9 are each selected from hydrogen, R 11 Selected from 4-chloro, n=1, R 14 R 15 R 16 or R 17 The components are selected from hydrogen, and W is selected from hydrogen, which is compound A3.

[0081] Active component B consists of the following: benzo[unclear]fluopyram B1, fluopyram B4, fluopyram B5, boscalid B9, thifluzamide B13, fluopyram hydroxylamine B14, fluopyram B27, azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorpholine B41, dimethomorpholine B42, dimethomorpholine B43, benzyl benzoate B44, metalaxyl B46, ethirimol sulfonate B56, ethirimol B58, fludioxonil B65, ethoxysulfonate B73, benomyl B74, cyazofamid B78, chlorfluazuron B91, prochloraz B95, fluoxapiproline B116, and fluoxapiproline. B117, Polyoxin B124, Kasugamycin B129, Zineb B134, Mancozeb B135, Mancozeb B136, Propineb B137, Captan B147, Chlorothalonil B149, Thiazole Zinc B159, Quinoline Copper B160, Picarbrazox B163, Aminopyrifen B164, Metyltetraprole B165.

[0082] The test composition consists of active component A1, each active component B, active component A1, and each active component B; wherein, active component B comprises benzo[a]fluopyram B1, fluopyram B4, fluopyram B5, boscalid B9, thifluzamide B13, fluopyram hydroxylamine B14, fluopyram B27, azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorpholine B41, dimethomorpholine B42, dimethomorpholine B43, benzymazole B44, metalaxyl B46, ethirimol sulfonate B56, ethirimol B58, fludioxonil B65, ethoxysulfonate B73, benomyl B74, cyazofamid B78, chlorfluazuron B91, prochloraz B95, fluoxapiproline B116, and fluoxapiproline. A composition consisting of B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, mancozeb B136, propineb B137, captan B147, chlorothalonil B149, thiamethoxam B159, quinoline copper B160, picarbutrazox B163, aminopyrifen B164, and metyltetraprole B165.

[0083] The test composition is active component A2 reacted with / or reacted with benzo[a]fluopyram B1, fluopyram B4, fluopyram B5, boscalid B9, thifluzamide B13, fluopyram hydroxylamine B14, fluopyram B27, azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorpholine B41, dimethomorpholine B42, dimethomorpholine B43, benzylamid B44, metalaxyl B46, ethirimol sulfonate B56, ethirimol B58, fludioxonil B65, ethoxysulfonate B73, benomyl B74, cyazofamid B78, chlorfluazuron B91, prochloraz B95, fluoxapiproline B116, and fluoxapiproline. A composition consisting of B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, mancozeb B136, propineb B137, captan B147, chlorothalonil B149, thiamethoxam B159, quinoline copper B160, picarbutrazox B163, aminopyrifen B164, and metyltetraprole B165.

[0084] The test composition is active component A3 reacted with / or reacted with benzo[a]fluopyram B1, fluopyram B4, fluopyram B5, boscalid B9, thifluzamide B13, fluopyram hydroxylamine B14, fluopyram B27, azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorpholine B41, dimethomorpholine B42, dimethomorpholine B43, benzylamid B44, metalaxyl B46, ethirimol sulfonate B56, ethirimol B58, fludioxonil B65, ethoxysulfonate B73, benomyl B74, cyazofamid B78, chlorfluazuron B91, prochloraz B95, fluthiazopyr B116, and fluoxapiproline. A composition consisting of B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, mancozeb B136, propineb B137, captan B147, chlorothalonil B149, thiamethoxam B159, quinoline copper B160, picarbutrazox B163, aminopyrifen B164, and metyltetraprole B165.

[0085] The test composition is active component A4 reacted with / or reacted with benzo[a]fluopyram B1, fluopyram B4, fluopyram B5, boscalid B9, thifluzamide B13, fluopyram hydroxylamine B14, fluopyram B27, azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorpholine B41, dimethomorpholine B42, dimethomorpholine B43, benzylamid B44, metalaxyl B46, ethirimol sulfonate B56, ethirimol B58, fludioxonil B65, ethoxysulfonate B73, benomyl B74, cyazofamid B78, chlorfluazuron B91, prochloraz B95, fluthiazopyr B116, and fluoxapiproline. A composition consisting of B117, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B135, mancozeb B136, propineb B137, captan B147, chlorothalonil B149, thiamethoxam B159, quinoline copper B160, picarbutrazox B163, aminopyrifen B164, and metyltetraprole B165.

[0086] Specific methods:

[0087] Dissolve each of the above active components or compositions in acetone (the volume ratio of acetone to spray volume is equal to or less than 0.05), dilute with water containing 0.1% Tween 80, and prepare a test solution of the required concentration. Separately prepare a test solution of the composition according to the set ratio. Using a crop sprayer, spray the test solution onto uniform host plants (not inoculated or treated with other drugs before application) grown in a greenhouse. Inoculate the plants with the disease 24 hours later. Based on the characteristics of the disease, plants requiring temperature and humidity control are inoculated and then cultured in a climate chamber until infection is complete, at which point they are transferred to the greenhouse. Plants not requiring humidity control are directly transferred to the greenhouse after inoculation. After the control group has fully developed the disease, conduct a disease survey and record the total number of leaves, the number of diseased leaves, and the disease severity.

[0088] Disease classification method:

[0089] Grade 0: The entire plant is disease-free;

[0090] Grade 1: Lesions cover less than 5% of the total leaf area;

[0091] Grade 3: Lesions cover 6-10% of the entire leaf area;

[0092] Grade 5: Lesions cover 11-20% of the entire leaf area;

[0093] Grade 7: Lesions cover 21-50% of the entire leaf area;

[0094] Level 9: The lesion area covers more than 51% of the entire leaf area.

[0095] The observed efficacy (C) of the active ingredient or composition obs Calculate using the commonly used formula for pesticide efficacy evaluation (corrected efficacy calculation formula):

[0096]

[0097] An efficacy of "0" indicates that the infection level of the treated crop is the same as that of the untreated control crop; an efficacy of "100" indicates that the treated crop is not infected.

[0098] The intended potency of the composition (C) exp The effect was determined using the Abbott method (see Liu Xuemin et al., Synergistic Effect of Mixed Fungicides, Pesticide Science and Management, 2002, 23(5), 12-15).

[0099] C exp =X+Y–XY / 100

[0100] In the formula:

[0101] X: The efficacy of active ingredient A at a concentration of a;

[0102] Y: The efficacy of active component B at a concentration of b.

[0103] The synergistic effect of the composition was observed using efficacy (C). obs ) and expected effectiveness (C exp The ratio (synergistic ratio) is used for evaluation. When the ratio (synergistic ratio) > 1, the composition exhibits a synergistic effect; when the ratio (synergistic ratio) = 1, the composition exhibits an additive effect; when the ratio (synergistic ratio) < 1, the composition exhibits an antagonistic effect.

[0104] Example 1: Experiment on the control of cucumber powdery mildew 1

[0105] Potted cucumber seedlings of variety "Jinyan-4" at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). After 24 hours, powdery mildew spores were sprayed onto the leaves using an inoculator and cultured in a greenhouse. After 10 days, when the control group had fully developed the disease, a disease survey was conducted.

[0106] The activity data and synergistic effects of each individual active component and the composition of the present invention in controlling cucumber powdery mildew are shown in Tables 1 and 2.

[0107] The results in Table 2 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on cucumber powdery mildew within the experimental ratio range.

[0108] Table 1. Activity of individual active components

[0109] Table 2. Activity and synergistic effect of the compositions of the present invention

[0110]

[0111] Example 2: Experiment 2 on the control of cucumber powdery mildew

[0112] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). After 24 hours, powdery mildew spores were sprayed onto the leaves using a grafting device and cultured in a greenhouse. After 10 days, when the control group had fully developed the disease, a disease survey was conducted.

[0113] The activity data and synergistic effects of each individual active component and the composition of the present invention in controlling cucumber powdery mildew are shown in Tables 3 and 4.

[0114] The results in Table 4 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C expThe ratio of all values ​​is >1, indicating that the composition has a synergistic effect on cucumber powdery mildew within the experimental ratio range.

[0115] Table 3 Activity of individual active components

[0116]

[0117] Table 4. Activity and synergistic effect of the compositions of the present invention

[0118]

[0119] Example 3: Experiment on the control of powdery mildew in melons

[0120] Potted four-leaf stage melon seedlings of the variety "Mixian Melon" (1-2 leaves were removed before the experiment, leaving only 3-4 leaves) were sprayed with aqueous solutions of each active component or combination (concentrations as shown in the table below). 24 hours later, a suspension of melon powdery mildew spores was inoculated onto the leaves and cultured in a greenhouse. After 15 days, when the control group had developed sufficient disease, a disease survey was conducted.

[0121] The activity data of each individual active component of this invention in preventing powdery mildew in melons are shown in Table 5.

[0122] The activity data and synergistic effects of the composition of the present invention in controlling powdery mildew in melons are shown in Table 6.

[0123] The results in Table 6 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​was >1, indicating that the composition had a synergistic effect on powdery mildew in melons within the experimental ratio range.

[0124] Table 5. Activity of individual active components

[0125]

[0126]

[0127] Table 6. Activity and synergistic effects of the compositions of the present invention

[0128] Example 4: Experiment on the control of powdery mildew in peppers

[0129] Potted six-leaf stage pepper seedlings of the "Qingyuanjiao" variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). After 24 hours, pepper powdery mildew spores were inoculated on the back of the leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 20-25 days, when the control group was fully infected, a disease survey was conducted.

[0130] The activity data of each individual active component of this invention in controlling powdery mildew of peppers are shown in Tables 7 and 8.

[0131] The activity data and synergistic effects of the composition of the present invention in controlling powdery mildew of peppers are shown in Tables 9 and 10.

[0132] The results in Tables 9 and 10 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on powdery mildew of pepper within the experimental ratio range.

[0133] Table 7. Activity of individual active components

[0134]

[0135] Table 8. Activity of individual active components

[0136]

[0137] Table 9. Activity and synergistic effects of the compositions of the present invention

[0138]

[0139] Table 10 Activity and synergistic effects of the compositions of the present invention

[0140] Example 5: Experiment on the control of powdery mildew in common beans

[0141] Potted two-leaf stage common bean seedlings of variety "Fengshou No. 1" were sprayed with aqueous solutions of each active component or combination (the concentrations of the effective ingredients are shown in the table below). After spraying, the seedlings were allowed to air dry naturally. 24 hours later, a suspension of common bean powdery mildew pathogen spores (5×10⁻⁶) was applied. 6 Inoculate the leaves with 100 cells / ml onto bean leaves, air dry them naturally, and then transfer them to a greenhouse for cultivation. The cultivation conditions are: daytime temperature 23-28℃, nighttime temperature 18-20℃. After the control group has developed sufficient disease, conduct a disease survey.

[0142] The activity data of each individual active component of this invention in preventing powdery mildew of common bean are shown in Table 11.

[0143] The activity data and synergistic effects of the composition of the present invention in preventing powdery mildew of common beans are shown in Table 12.

[0144] The results in Table 12 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on powdery mildew of beans within the experimental ratio range.

[0145] Table 11 Activity of individual active components

[0146]

[0147] Table 12 Activity and synergistic effect of the compositions of the present invention

[0148] Example 6: Experiment on the control of tobacco powdery mildew

[0149] Potted tobacco seedlings of variety "CN89" at the six-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). After 24 hours, tobacco powdery mildew spore suspension was inoculated onto the leaves of the seedlings and then directly transferred to a greenhouse for cultivation. After 20 days, when the control group had fully developed the disease, a disease survey was conducted.

[0150] The activity data of each individual active component of this invention in preventing and controlling tobacco powdery mildew are shown in Table 13.

[0151] The activity data and synergistic effects of the composition of the present invention in preventing and controlling tobacco powdery mildew are shown in Table 14.

[0152] The results in Table 14 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition exhibits a synergistic effect on tobacco powdery mildew within the experimental ratio range.

[0153] Table 13 Activity of individual active components

[0154]

[0155]

[0156] Table 14 Activity and synergistic effects of the compositions of the present invention

[0157] Example 7: Experiment on the control of corn rust

[0158] Potted corn seedlings of the variety "Golden Rice" at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, corn rust fungus spore suspension was inoculated onto the corn leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, when the control group was fully infected, the disease was investigated.

[0159] The activity data of each individual active component of this invention in preventing corn rust are shown in Table 15.

[0160] The activity data and synergistic effects of the composition of the present invention in controlling corn rust are shown in Table 16.

[0161] The results in Table 16 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratios of all values ​​were >1, indicating that the composition exhibited a synergistic effect on corn rust within the experimental ratio range.

[0162] Table 15 Activity of Individual Active Components

[0163]

[0164] Table 16 Activity and synergistic effects of the compositions of the present invention

[0165]

[0166] Example 8: Experiment on the control of cucumber downy mildew 1

[0167] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, a suspension of sporangia of cucumber downy mildew pathogen was inoculated onto the cucumber leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, when the control group was fully infected, a disease survey was conducted.

[0168] The activity data of each individual active component of this invention in preventing cucumber downy mildew are shown in Table 17.

[0169] The activity data and synergistic effects of the composition of the present invention in controlling cucumber downy mildew are shown in Table 18.

[0170] The results in Table 18 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the experimental ratio range.

[0171] Table 17 Activity of Individual Active Components

[0172]

[0173]

[0174] Table 18 Activity and synergistic effects of the compositions of the present invention

[0175]

[0176]

[0177] Example 9: Experiment 2 on the control of cucumber downy mildew

[0178] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, a suspension of sporangia of cucumber downy mildew pathogen was inoculated onto the cucumber leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, when the control group was fully infected, a disease survey was conducted.

[0179] The activity data of each individual active component of this invention in preventing cucumber downy mildew are shown in Table 19.

[0180] The activity data and synergistic effects of the composition of the present invention in controlling cucumber downy mildew are shown in Table 20.

[0181] The results in Table 20 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the experimental ratio range.

[0182] Table 19 Activity of Individual Active Components

[0183]

[0184] Table 20 Activity and synergistic effects of the compositions of the present invention

[0185]

[0186]

[0187] Example 10: Experiment 3 on the control of cucumber downy mildew

[0188] The experiment was conducted in accordance with the relevant content of the national standard GB / T 17980.26-2000: Guidelines for Field Efficacy Tests of Pesticides (I) - Control of Downy Mildew in Cucumbers with Fungicides. The experimental site was located in a protected area in Bayi Town, Sujiatun District, Shenyang City. The cucumber variety was Xintai Mici, and the management level was medium. At the time of the experiment, the cucumbers were in the fruiting stage, and downy mildew had occurred. The plot area was approximately 25m². 2 The cucumbers were sprayed with the pesticide according to the experimentally set dosage. The pesticide was applied twice, with a 7-day interval between applications. Ten days after the second application, the incidence of downy mildew in cucumbers in each plot was investigated. Four samples were taken from each plot, with eight plants taken from each sample. The disease incidence of the entire leaf of each plant was investigated from top to bottom.

[0189] The activity data of each individual active component of this invention in preventing cucumber downy mildew are shown in Table 21.

[0190] The activity data and synergistic effects of the composition of the present invention in controlling cucumber downy mildew are shown in Table 22.

[0191] The results in Table 22 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the experimental ratio range.

[0192] Table 21 Activity of individual active components

[0193]

[0194] Table 22 Activity and synergistic effect of the compositions of the present invention

[0195]

[0196] Example 11 Experiment 4 on the control of cucumber downy mildew

[0197] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, a suspension of sporangia of cucumber downy mildew pathogen was inoculated onto the cucumber leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, when the control group was fully infected, a disease survey was conducted.

[0198] The activity data of each individual active component of this invention in preventing cucumber downy mildew are shown in Table 23.

[0199] The activity data and synergistic effects of the composition of the present invention in controlling cucumber downy mildew are shown in Table 24.

[0200] The results in Table 24 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber downy mildew within the experimental ratio range.

[0201] Table 23 Activity of individual active components

[0202]

[0203]

[0204] Table 24 Activity and synergistic effects of the compositions of the present invention

[0205] Example 12 Experiment on the control of grape downy mildew 1

[0206] Five-leaf stage potted grape seedlings of the 'Seedless White Chicken Heart' variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, a suspension of sporangia of the grape downy mildew pathogen was inoculated onto the grape leaves. The grape seedlings were then placed in a climate chamber for cultivation. After the disease had completed its infection, the seedlings were moved to a greenhouse for cultivation. After 7 days, when the control group had fully developed the disease, a disease survey was conducted.

[0207] The activity data of each individual active component of this invention in controlling grape downy mildew are shown in Table 25.

[0208] The activity data and synergistic effects of the composition of the present invention in controlling grape downy mildew are shown in Table 26.

[0209] The results in Table 26 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on grape downy mildew within the experimental formulation range.

[0210] Table 25 Activity of Individual Active Components

[0211]

[0212] Table 26 Activity and synergistic effect of the compositions of the present invention

[0213]

[0214] Example 13: Experiment 2 on the control of grape downy mildew

[0215] Five-leaf stage potted grape seedlings of the 'Seedless White Chicken Heart' variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, a suspension of sporangia of the grape downy mildew pathogen was inoculated onto the grape leaves. The grape seedlings were then placed in a climate chamber for cultivation. After the disease had completed its infection, the seedlings were moved to a greenhouse for cultivation. After 7 days, when the control group had fully developed the disease, a disease survey was conducted.

[0216] The activity data of each individual active component of this invention in controlling grape downy mildew are shown in Table 27.

[0217] The activity data and synergistic effects of the composition of the present invention in controlling grape downy mildew are shown in Table 28.

[0218] The results in Table 28 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on grape downy mildew within the experimental formulation range.

[0219] Table 27 Activity of Individual Active Components

[0220]

[0221] Table 28 Activity and synergistic effects of the compositions of the present invention

[0222]

[0223]

[0224] Example 14: Experiment 3 on the control of grape downy mildew

[0225] Five-leaf stage potted grape seedlings of the 'Seedless White Chicken Heart' variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, a suspension of sporangia of the grape downy mildew pathogen was inoculated onto the grape leaves. The grape seedlings were then placed in a climate chamber for cultivation. After the disease had completed its infection, the seedlings were moved to a greenhouse for cultivation. After 7 days, when the control group had fully developed the disease, a disease survey was conducted.

[0226] The activity data of each individual active component of this invention in controlling grape downy mildew are shown in Table 29.

[0227] The activity data and synergistic effects of the composition of the present invention in controlling grape downy mildew are shown in Table 30.

[0228] The results in Table 30 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on grape downy mildew within the experimental ratio range.

[0229] Table 29 Activity of Individual Active Components

[0230]

[0231] Table 30 Activity and synergistic effect of the compositions of the present invention

[0232]

[0233] Example 15: Experiment 4 on the control of grape downy mildew

[0234] Five-leaf stage potted grape seedlings of the 'Seedless White Chicken Heart' variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, a suspension of sporangia of the grape downy mildew pathogen was inoculated onto the grape leaves. The grape seedlings were then placed in a climate chamber for cultivation. After the disease had completed its infection, the seedlings were moved to a greenhouse for cultivation. After 7 days, when the control group had fully developed the disease, a disease survey was conducted.

[0235] The activity data of each individual active component of this invention in controlling grape downy mildew are shown in Table 31.

[0236] The activity data and synergistic effects of the composition of the present invention in controlling grape downy mildew are shown in Table 32.

[0237] The results in Table 32 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on grape downy mildew within the experimental formulation range.

[0238] Table 31 Activity of individual active components

[0239]

[0240] Table 32 Activity and synergistic effect of the compositions of the present invention

[0241]

[0242] Example 16: Experiment on the control of downy mildew in Chinese cabbage

[0243] Potted five-leaf stage Chinese cabbage seedlings of the variety "Four Seasons Chinese Cabbage" were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective ingredients are shown in the table below). 24 hours later, sporangia of downy mildew fungus were inoculated on the back of the leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 5-7 days, when the control group was fully infected, a disease survey was conducted.

[0244] The activity data of each individual active component of this invention in preventing downy mildew of Chinese cabbage are shown in Table 33.

[0245] The activity data and synergistic effects of the composition of the present invention in preventing downy mildew of Chinese cabbage are shown in Table 34.

[0246] The results in Table 34 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​was >1, indicating that the composition exhibited a synergistic effect on downy mildew of Chinese cabbage within the experimental ratio range.

[0247] Table 33 Activity of individual active components

[0248]

[0249]

[0250] Table 34 Activity and synergistic effects of the compositions of the present invention

[0251] Example 17: Experiment on the control of sunflower downy mildew

[0252] Potted sunflower seedlings of the 'Sandaomei' variety, at the six-leaf stage (with 1-4 leaves removed before the experiment, leaving only 5-6 leaves), were sprayed with aqueous solutions of various active components or combinations (the concentrations of the active ingredients are shown in the table below). 24 hours later, a sporangium suspension of the sunflower downy mildew pathogen was inoculated onto the leaves and cultured in a climate chamber. After the disease had completed its infection, the seedlings were transferred to a greenhouse for further cultivation. After 12 days, once the control group had developed sufficient disease, a disease survey was conducted.

[0253] The activity data of each individual active component of this invention in controlling downy mildew of sunflower are shown in Table 35.

[0254] The activity data and synergistic effects of the composition of the present invention in controlling downy mildew of sunflower are shown in Table 36.

[0255] The results in Table 36 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on sunflower downy mildew within the experimental ratio range.

[0256] Table 35 Activity of Individual Active Components

[0257]

[0258] Table 36 Activity and synergistic effects of the compositions of the present invention

[0259]

[0260] Example 18: Experiment on the control of tomato late blight 1

[0261] Potted tomato seedlings of the variety "Pinktail" at the five-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, a sporangium suspension of the tomato late blight pathogen was inoculated onto the tomato leaves, and the tomato seedlings were placed in a climate chamber for cultivation. After the disease was fully infected, they were transferred to a greenhouse for cultivation. After 7 days, when the control group was fully infected, the disease was investigated.

[0262] The activity data of each individual active component of this invention in controlling tomato late blight are shown in Table 37.

[0263] The activity data and synergistic effects of the composition of the present invention in controlling late blight of tomato are shown in Table 38.

[0264] The results in Table 38 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on tomato late blight within the experimental ratio range.

[0265] Table 37 Activity of Individual Active Components

[0266]

[0267]

[0268] Table 38 Activity and synergistic effects of the compositions of the present invention

[0269]

[0270] Example 19: Experiment 2 on the control of tomato late blight

[0271] Potted tomato seedlings of the variety "Pinktail" at the five-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, a sporangium suspension of the tomato late blight pathogen was inoculated onto the tomato leaves, and the tomato seedlings were placed in a climate chamber for cultivation. After the disease was fully infected, they were transferred to a greenhouse for cultivation. After 7 days, when the control group was fully infected, the disease was investigated.

[0272] The activity data of each individual active component of this invention in preventing and controlling late blight of tomato are shown in Table 39.

[0273] The activity data and synergistic effects of the composition of the present invention in controlling late blight of tomato are shown in Table 40.

[0274] The results in Table 40 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on tomato late blight within the experimental ratio range.

[0275] Table 39 Activity of Individual Active Components

[0276]

[0277] Table 40 Activity and synergistic effect of the compositions of the present invention

[0278]

[0279] Example 20: Experiment on the control of cucumber anthracnose 1

[0280] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations. After spraying, the seedlings were allowed to air dry naturally. 24 hours later, an aqueous suspension of cucumber anthracnose spores was inoculated onto the cucumber leaves and cultured in a climate chamber. After the disease had completed its infection, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, a disease survey was conducted. The leaves were graded according to the degree of pathogen infection on the leaves. The total number of leaves, the number of diseased leaves, and the disease grade were recorded. The efficacy of the pesticide was calculated using a formula.

[0281] The activity data of each individual active component of this invention in preventing and controlling cucumber anthracnose are shown in Table 41.

[0282] The activity data and synergistic effects of the composition of the present invention in preventing and controlling cucumber anthracnose are shown in Table 42.

[0283] The results in Table 42 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber anthracnose within the experimental ratio range.

[0284] Table 41 Activity of individual active components

[0285]

[0286] Table 42 Activity and synergistic effect of the compositions of the present invention

[0287] Example 21 Experiment 2 on the control of cucumber anthracnose

[0288] Potted cucumber seedlings of the 'Xintai Mici' variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations. After spraying, the seedlings were allowed to air dry naturally. 24 hours later, an aqueous suspension of cucumber anthracnose spores was inoculated onto the cucumber leaves and cultured in a climate chamber. After the disease had completed its infection, the seedlings were transferred to a greenhouse for further cultivation. After 7 days, a disease survey was conducted. The leaves were graded according to the degree of pathogen infection on the leaves. The total number of leaves, the number of diseased leaves, and the disease grade were recorded. The efficacy of the pesticide was calculated using a formula.

[0289] The activity data of each individual active component of this invention in preventing and controlling cucumber anthracnose are shown in Table 43.

[0290] The activity data and synergistic effects of the composition of the present invention in preventing and controlling cucumber anthracnose are shown in Table 44.

[0291] The results in Table 44 below show that the ratio of the observed potency (Cobs) to the expected potency (Cexp) of the composition is greater than 1, indicating that the composition has a synergistic effect on cucumber anthracnose within the experimental ratio range.

[0292] Table 43 Activity of individual active components

[0293]

[0294] Table 44 Activity and synergistic effect of the compositions of the present invention

[0295] Example 22: Experiment on the control of anthracnose in peppers

[0296] Potted six-leaf stage pepper seedlings of the "Qingyuanjiao" variety were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). 24 hours later, pepper anthracnose spore suspension was inoculated on the back of the leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 5-7 days, when the control group was fully infected, a disease survey was conducted.

[0297] The activity data of each individual active component of this invention in preventing and controlling anthracnose in peppers are shown in Table 45.

[0298] The activity data and synergistic effects of the composition of the present invention in controlling anthracnose in peppers are shown in Table 46.

[0299] The results in Table 46 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratios of all values ​​were >1, indicating that the composition exhibited a synergistic effect on anthracnose in peppers within the experimental ratio range.

[0300] Table 45 Activity of individual active components

[0301]

[0302] Table 46 Activity and synergistic effect of the compositions of the present invention

[0303] Example 23: Experiment on the control of eggplant brown spot disease

[0304] Potted eggplant seedlings of variety "Liaoqie No. 1" at the five-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). 24 hours later, eggplant brown spot spore suspension was inoculated onto eggplant leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 10 days, when the control group was fully infected, a disease survey was conducted.

[0305] The activity data of each individual active component of this invention in preventing and controlling eggplant brown spot disease are shown in Table 47.

[0306] The activity data and synergistic effects of the composition of the present invention in preventing and controlling eggplant brown spot disease are shown in Table 48.

[0307] The results in Table 48 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on eggplant brown spot disease within the experimental ratio range.

[0308] Table 47 Activity of Individual Active Components

[0309]

[0310]

[0311] Table 48 Activity and synergistic effects of the compositions of the present invention

[0312]

[0313]

[0314] Example 24: Experiment on the control of eggplant leaf spot disease caused by Corynebacterium tumefaciens

[0315] Potted eggplant seedlings of variety "Liaoqie No. 1" at the five-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). 24 hours later, a suspension of eggplant leaf spot fungus spores was inoculated onto the eggplant leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 8 days, when the control group was fully infected, a disease survey was conducted.

[0316] The activity data of each individual active component of this invention in preventing and controlling eggplant leaf spot disease are shown in Table 49.

[0317] The activity data and synergistic effects of the composition of the present invention in controlling eggplant leaf spot disease are shown in Table 50.

[0318] The results in Table 50 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition exhibits a synergistic effect on eggplant leaf spot disease within the experimental ratio range.

[0319] Table 49 Activity of Individual Active Components

[0320] Table 50 Activity and synergistic effect of the compositions of the present invention

[0321]

[0322] Example 25: Experiment on the control of pear black spot disease

[0323] Tender leaves from potted seedlings of the 'Fragrant Pear' variety were disinfected, rinsed with sterile water, and air-dried for later use. The leaves were then treated with aqueous solutions of the active components or combinations (concentrations as shown in the table below). After 24 hours, a suspension of pear black spot fungus spores was inoculated onto the leaves and placed in a petri dish (containing 2% water agar) under constant temperature and light. After 14 days, once the control group had developed sufficient disease, a disease survey was conducted.

[0324] The activity data of each individual active component of this invention in preventing and controlling pear black spot disease are shown in Table 51.

[0325] The activity data and synergistic effects of the composition of the present invention in preventing and controlling pear black spot disease are shown in Table 52.

[0326] The results in Table 52 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on pear black spot disease within the experimental ratio range.

[0327] Table 51 Activity of individual active components

[0328]

[0329]

[0330] Table 52 Activity and synergistic effect of the compositions of the present invention

[0331] Example 26: Experiment on the control of peanut leaf spot disease 1

[0332] Two pairs of compound-leaved peanut seedlings of the 'Baisha' variety were sprayed with aqueous solutions of each active component or combination (concentrations as shown in the table below). 24 hours later, a suspension of peanut brown spores was inoculated onto the leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 10-12 days, when the control group was fully infected, a disease survey was conducted.

[0333] The activity data of each individual active component of this invention in preventing peanut leaf spot disease are shown in Table 53.

[0334] The activity data and synergistic effects of the composition of the present invention in controlling peanut leaf spot disease are shown in Table 54.

[0335] The results in Table 54 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on peanut leaf spot disease within the experimental ratio range.

[0336] Table 53 Activity of individual active components

[0337]

[0338] Table 54 Activity and synergistic effect of the compositions of the present invention

[0339]

[0340] Example 27 Experiment 2 on the control of peanut leaf spot disease

[0341] Two pairs of compound-leaved peanut seedlings of the 'Baisha' variety were sprayed with aqueous solutions of each active component or combination (concentrations as shown in the table below). 24 hours later, a suspension of peanut brown spores was inoculated onto the leaves and cultured in a climate chamber. After the disease was fully infected, the seedlings were transferred to a greenhouse for further cultivation. After 10-12 days, when the control group was fully infected, a disease survey was conducted.

[0342] The activity data of each individual active component of this invention in preventing peanut leaf spot disease are shown in Table 55.

[0343] The activity data and synergistic effects of the composition of the present invention in controlling peanut leaf spot disease are shown in Table 56.

[0344] The results in Table 56 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on peanut leaf spot disease within the experimental ratio range.

[0345] Table 55 Activity of individual active components

[0346]

[0347] Table 56 Activity and synergistic effect of the compositions of the present invention

[0348]

[0349] Example 28: Experiment on the control of wheat scab

[0350] Potted wheat seedlings of variety "Liaochun 18" at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). 24 hours later, wheat scab spore suspension was inoculated onto the leaves and cultured in a greenhouse. After 5 days, when the control group had fully developed the disease, a disease survey was conducted.

[0351] The activity data of each individual active component of this invention in preventing wheat scab are shown in Table 57.

[0352] The activity data and synergistic effects of the composition of the present invention in controlling wheat scab are shown in Table 58.

[0353] The results in Table 58 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratios of all values ​​were >1, indicating that the composition exhibited a synergistic effect against wheat scab within the experimental ratio range.

[0354] Table 57 Activity of Individual Active Components

[0355]

[0356] Table 58 Activity and synergistic effects of the compositions of the present invention

[0357]

[0358]

[0359] Example 29: Experiment on the control of rice sheath blight 1

[0360] Potted rice seedlings of the "Longdao 18" variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). 24 hours later, rice leaf blight mycelial suspension was inoculated onto the rice leaves and cultured in a greenhouse. After 5 days, when the control group had fully developed the disease, a disease survey was conducted.

[0361] The activity data of each individual active component of this invention in controlling rice sheath blight are shown in Table 59.

[0362] The activity data and synergistic effects of the composition of the present invention in controlling rice sheath blight are shown in Table 60.

[0363] The results in Table 60 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition exhibits a synergistic effect on rice sheath blight within the experimental ratio range.

[0364] Table 59 Activity of individual active components

[0365]

[0366]

[0367] Table 60 Activity and synergistic effect of the compositions of the present invention

[0368]

[0369] Example 30: Experiment 2 on the control of rice sheath blight

[0370] Potted rice seedlings of the "Longdao 18" variety at the two-leaf stage were sprayed with aqueous solutions of various active components or combinations (concentrations as shown in the table below). 24 hours later, rice leaf blight mycelial suspension was inoculated onto the rice leaves and cultured in a greenhouse. After 5 days, when the control group had fully developed the disease, a disease survey was conducted.

[0371] The activity data of each individual active component of this invention in controlling rice sheath blight are shown in Table 61.

[0372] The activity data and synergistic effects of the composition of the present invention in controlling rice sheath blight are shown in Table 62.

[0373] The results in Table 62 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition exhibits a synergistic effect on rice sheath blight within the experimental ratio range.

[0374] Table 61 Activity of individual active components

[0375]

[0376]

[0377] Table 62 Activity and synergistic effect of the compositions of the present invention

[0378]

[0379] Example 31: Experiment on the control of rice bacterial leaf blight

[0380] Rice (variety Koshihikari) was planted in identical pots in a greenhouse, 8 plants per pot. When the plants reached the four-leaf stage, they were sprayed with aqueous solutions of the active components or combinations. 24 hours later, the activated strain of rice bacterial blight virus was evenly sprayed onto the rice leaves, and the plants were kept humidified under artificial atmosphere for 24 hours before being moved back to the greenhouse for further cultivation. After the water control showed sufficient disease development, the length of lesions on the leaves of each treatment was measured, and the disease inhibition rate was calculated using the following formula to observe the efficacy.

[0381]

[0382] The activity data of each individual active component of this invention in preventing and controlling rice bacterial blight are shown in Table 63.

[0383] The activity data and synergistic effects of the composition of the present invention in controlling rice bacterial blight are shown in Table 64.

[0384] The results in Table 64 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on rice bacterial blight within the experimental ratio range.

[0385] Table 63 Activity of individual active components

[0386]

[0387] Table 64 Activity and synergistic effects of the compositions of the present invention

[0388]

[0389] Example 32: Treatment trial for anthrax in chili peppers

[0390] Potted six-leaf stage pepper seedlings of the "Qingyuanjiao" variety were inoculated with a suspension of pepper anthracnose spores and cultured in a climate chamber. After 24 hours, they were sprayed with aqueous solutions of each active component or combination (the concentrations of the effective ingredients are shown in the table below), and then transferred to a greenhouse for cultivation. After 5-7 days, when the control group had fully developed the disease, a disease survey was conducted.

[0391] The therapeutic activity data of each individual active component and composition of the present invention against anthrax of pepper are shown in Tables 65 and 66.

[0392] The results in Tables 65 and 66 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratios of all values ​​were >1, indicating that the composition exhibited a synergistic effect on anthracnose in peppers within the experimental ratio range.

[0393] Table 65. Therapeutic effects of active ingredients and synergistic effects of the composition.

[0394]

[0395] Table 66. Therapeutic effects of active ingredients and synergistic effects of the composition.

[0396]

[0397] Example 33: Duration test of control over powdery mildew in peppers

[0398] Potted pepper seedlings of the "Qingyuanjiao" variety at the six-leaf stage were sprayed with aqueous solutions of various active components or combinations (the concentrations of the effective components are shown in the table below). After 1, 3, 5, 7 and 10 days, pepper powdery mildew spores were sprayed onto the back of the leaves using an inoculator and cultured in a greenhouse. After 20-25 days, when the control group had fully developed the disease, the disease was investigated.

[0399] The activity data of each individual active component and the composition of the present invention in controlling powdery mildew of peppers are shown in Table 67.

[0400] The results in Table 67 below show that the efficacy of both the individual components and the combined formulation of this invention against powdery mildew of peppers gradually decreased with prolonged inoculation time. At the same concentration, when inoculated 5 days after application, the efficacy of the individual components was 50% lower, while the efficacy of the combined formulation was higher than 60%. When inoculated 10 days after application, the efficacy of the individual components was not significant, while the efficacy of the combined formulation was around 30%, showing a clear control effect. This indicates that using the individual components of this invention in the form of a combined formulation enhances the sustained activity of the agent against powdery mildew of peppers.

[0401] Table 67. The sustained activity and synergistic effect of the active ingredients

[0402]

[0403] Example 34 Field trial for the control of cucumber powdery mildew

[0404] In a solar greenhouse, during the mid-stage of powdery mildew on cucumbers (variety "Fruit Cucumber"), spray treatment was carried out with aqueous solutions of various active components or combinations (concentrations as shown in the table below), and a disease survey was conducted 15 days later.

[0405] The activity data of each individual active component of this invention in controlling cucumber powdery mildew are shown in Table 68.

[0406] The activity data and synergistic effects of the composition of the present invention in controlling cucumber powdery mildew are shown in Table 69.

[0407] The results in Table 69 below show the observed potency (C) of the composition. obs ) and expected effectiveness (C exp The ratio of all values ​​is >1, indicating that the composition has a synergistic effect on cucumber powdery mildew in the field within the experimental ratio range.

[0408] Table 68 Activity of Individual Active Components

[0409]

[0410] Table 69 Activity and synergistic effects of the compositions of the present invention

[0411]

Claims

1. A fungicidal composition characterized in that: The composition is two active components A and B, and the weight ratio of active component A to active component B is 1:1-1:8; The active component A is a compound represented by general formula I-A or a salt thereof: I-A In the formula, R3 is selected from hydrogen; R4 and R5 are each selected from hydrogen; R6 and R7 are each selected from hydrogen; R8 and R9 are each selected from hydrogen; R 11 selected from 4-chloro; R 14 , R 15 , R 16 or R 17 are each selected from hydrogen; W is selected from hydrogen; n is 1; The salt of the compound represented by general formula I-A is a salt formed by the compound represented by general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid; The active component B is selected from metrafenone B74.

2. The fungicidal composition according to claim 1, characterized in that: The composition is active component A and active component B in a weight ratio of 1:1-1:8; The active component A is one or more of the compounds represented by general formula I-A or a salt thereof; In the formula, R3 is selected from hydrogen; R4 and R5 are each selected from hydrogen; R6 and R7 are each selected from hydrogen; R8 and R9 are each selected from hydrogen; R 11 selected from 4-chloro; n is 1; R 14 , R 15 , R 16 or R 17 are each selected from hydrogen; W is selected from hydrogen; The salt of the compound represented by general formula I-A is a salt formed by the compound represented by general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid; The active component B is selected from metrafenone B74.

3. The germicidal composition of claim 2, wherein: The composition is active component A and active component B in a weight ratio of 1:1-1:8; The active component A is one or more of the compounds represented by general formula I-A or a salt thereof; In the formula, R3 is selected from hydrogen; R4 and R5 are each selected from hydrogen; R6 and R7 are each selected from hydrogen; R8, R9are independently selected from hydrogen; R 11 selected from 4-chloro; n is 1; R 14 , R 15 , R 16 or R 17 are each selected from hydrogen; W is selected from hydrogen; The salt of the compound represented by general formula I-A is a salt formed by the compound represented by general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid; The active component B is selected from metrafenone B74.

4. Use of a bactericidal composition according to claim 1, characterized in that: The fungicidal composition is used for preparing a medicine for preventing and treating powdery mildew of plants.

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