Imaging device and computer-readable storage medium

Abstract

The present application discloses an imaging device, comprising: a position information acquisition module for obtaining position information of a target organ; an irradiation depth determination module for determining the irradiation depth of imaging rays from a detection point into the interior of a human body based on the position of the detection point and the target detection depth; a light source focus control module for determining the focus information of multiple light sources based on a preset magnification and irradiation depth; an irradiation module for controlling the multiple light sources to generate imaging rays to irradiate the detection point based on the focus information; an imaging module for obtaining first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and obtaining an image of the target organ based on the first imaging information. The imaging device provided in the embodiments of the present application is capable of performing microscopic imaging of a target organ using imaging rays.

Description

Technical Field

[0001] The present application belongs to the field of computer technology and medical technology, and more specifically, to an imaging device and a computer-readable storage medium. Background Art

[0002] As people's living standards improve, medical and health conditions and awareness of medical hygiene are also gradually improving and strengthening. During medical treatment or routine checkups, more and more methods and equipment are available for early screening of certain diseases, thereby preventing more diseases in their early stages. Imaging devices are one of the most commonly used devices and equipment in medical examinations. To improve the accuracy and convenience of disease examinations, continuous improvement of imaging devices is needed. Summary of the Invention

[0003] The purpose of the embodiments of the present application is to provide an imaging device and a computer-readable storage medium.

[0004] In a first aspect, an embodiment of the present application provides an imaging device, comprising:

[0005] A position information acquisition module is used to obtain position information of a target organ; the position information includes the position of a detection point corresponding to the target organ on the human body surface, and the distance between the target organ and the detection point;

[0006] an irradiation depth determination module, configured to determine the irradiation depth of the imaging radiation from the detection point into the human body according to the position of the detection point and a target detection depth; the target detection depth is determined according to the sampling depth of a biopsy tissue sample taken during microscopic examination of the target organ;

[0007] A light source focusing control module, configured to determine focusing information of the multiple light sources based on a preset magnification and the irradiation depth; the preset magnification being determined based on the magnification of a biopsy tissue obtained by microscopic examination of the target organ;

[0008] an irradiation module, configured to control the multiple light sources to generate imaging rays according to the focusing information, so as to irradiate the detection point;

[0009] An imaging module is configured to obtain first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and to obtain an image of the target organ based on the first imaging information.

[0010] In a second aspect, an embodiment of the present application provides a non-transitory computer-readable storage medium storing computer instructions, wherein the computer instructions are used to enable the computer to execute the steps performed by the device provided in any embodiment of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments or descriptions of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0012] Figure 1 A schematic structural diagram of an imaging device provided in an embodiment of the present application;

[0013] Figure 2 Schematic diagram of the positional relationship between target organs and detection points provided in the embodiments of the present application;

[0014] Figure 3 A schematic diagram of a spatial array light source according to an embodiment of the present application;

[0015] Figure 4 This is a schematic diagram of a single light source structure according to an embodiment of the present application;

[0016] Figure 5 A schematic diagram of an irradiation assembly according to an embodiment of the present application;

[0017] Figure 6 A schematic diagram showing a comparison of texture features in an embodiment of the present application;

[0018] Figure 7 This is a schematic diagram of the physical structure of an imaging device according to an example of the present application;

[0019] Figure 8 This is a schematic diagram of a focusing component according to an example of the present application. DETAILED DESCRIPTION

[0020] In order to make the technical problems, technical solutions and beneficial effects to be solved by this application more clearly understood, this application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0021] Embodiments of the present application provide an imaging device and a computer-readable storage medium.

[0022] The embodiments of the present invention described above are combinations of elements and features of the present invention. Unless otherwise mentioned, elements or features may be considered as optional. Each element or feature may be put into practice without being combined with other elements or features. In addition, embodiments of the present invention may be constructed by combining some elements and / or features. The order of operations described in the embodiments of the present invention may be rearranged. Some configurations of any one embodiment may be included in another embodiment and may be replaced by the corresponding configuration of another embodiment. It is obvious to those skilled in the art that claims that do not have a clear reference relationship to each other in the appended claims may be combined into embodiments of the present invention, or may be included as new claims in amendments after submitting the present invention.

[0023] In firmware or software configurations, embodiments of the present invention may be implemented in the form of modules, procedures, functions, and the like. Software codes may be stored in a memory unit and executed by a processor. The memory unit may be located inside or outside the processor and may send and receive data to and from the processor via various known means.

[0024] The embodiment of the present application provides an imaging device, such as Figure 1 Shown, including:

[0025] The position information obtaining module 101 is used to obtain the position information of the target organ; the position information includes the position of the detection point corresponding to the target organ on the human body surface, and the distance between the target organ and the detection point;

[0026] An irradiation depth determination module 102 is configured to determine the irradiation depth of the imaging radiation from the detection point into the human body based on the position of the detection point and a target detection depth, wherein the target detection depth is determined based on a sampling depth when performing a microscopic examination of a biopsy tissue of the target organ;

[0027] The light source focusing control module 103 is configured to determine the focusing information of the multiple light sources according to a preset magnification and the irradiation depth; the preset magnification is determined according to the magnification of the target organ when performing a microscopic examination of a biopsy tissue;

[0028] An irradiation module 104 is configured to control the multiple light sources to generate imaging rays according to the focusing information to illuminate the detection point;

[0029] The imaging module 105 is configured to obtain first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and to obtain an image of the target organ based on the first imaging information.

[0030] In the embodiments of the present application, the target organ may be a human organ, such as the lungs, stomach, liver, intestines, skin, head, etc., or a human body part, such as the chest, arms, legs, abdomen, pelvic area, etc. The human body surface may be the surface of human skin.

[0031] The distance between the target organ and the detection point is determined based on the depth of the tumor that may appear in the target organ.

[0032] In one embodiment, obtaining the position information of the target organ includes: determining the predicted position of the tumor on the target organ based on pre-processing information obtained by performing an initial scan on the target organ; determining the position of the detection point corresponding to the target organ on the human body surface based on the predicted tumor position and the type of the target organ; and determining the distance between the target organ and the detection point based on the type of the target organ. The initial scan may include at least one of the following operation modes: CT scanning, X-ray scanning, ultrasound detection, and nuclear magnetic resonance detection. Medical personnel can input the pre-processing information obtained by pre-detection methods such as ultrasound detection (which may be CT information, X-ray information, ultrasound information, ultrasound images, nuclear magnetic resonance images, information manually input by medical personnel, etc.) into the position information acquisition module, so that the position information acquisition module can further process the pre-processing information to obtain the position information of the target organ.

[0033] Furthermore, the position information acquisition module can also be used to determine the location of the detection point based on the position information of the target organ and the suspicious tissue information of the target organ. The suspicious tissue information of the target organ can be determined based on pre-processing information or based on information manually input by medical personnel. The suspicious tissue information of the target organ is specifically relative position information determined based on the pre-processing information. In a target organ, there can be at least one suspicious tissue, and the detection point can be located in the suspicious tissue or at the projection point on the human body surface at the junction of the suspicious tissue and normal tissue.

[0034] The detection point is a point on the surface of the human skin, and the distance between the target organ and the detection point is the distance between the target organ of the human body and the detection point (that is, the distance between the human organ and the detection point on the surface of the human skin), or the distance between the internal part of the human body and the detection point (that is, the distance between the human body part and the detection point on the surface of the human skin).

[0035] Before the irradiation depth determination module 102 determines the irradiation depth, the target detection depth can also be determined, specifically including: predicting the depth of the tissue to be detected in the target organ based on preprocessing information obtained by ultrasonic detection of the target organ, and determining the target detection depth based on the sampling depth of the tissue to be detected in the target organ when the biopsy tissue is detected under a microscope.

[0036] When examining biopsy tissue under a microscope, the sampling depth may be the depth of the target organ surface or the puncture depth of the target organ. Accordingly, before using a microscope to examine biopsy tissue, it is necessary to sample the tissue to be examined in the target organ. The tissue to be examined is the tissue peeled off from the surface of the target organ, or the tissue obtained from the inside of the target organ by a puncture device, or the tissue collected by an endoscope smear or print. Biopsy is the abbreviation of "living tissue examination", also known as surgical pathology examination, which refers to the technology of removing diseased tissue from the patient's body by cutting, clamping or puncturing for pathological examination in response to the needs of diagnosis and treatment. Biopsy tissue is the obtained tissue sample to be examined.

[0037] In this embodiment, the irradiation depth of the imaging radiation from the detection point into the human body can be equal to the sum of the target detection depth and the distance between the target organ and the detection point. Alternatively, the irradiation depth can be calculated by adding a certain margin to the sum of the target detection depth and the distance between the target organ and the detection point.

[0038] Determining the focusing information of the multiple light sources according to the illumination depth may include: determining whether each light source in the spatial array light source is illuminated and the illumination energy of the activated single light source according to the illumination depth as the focusing information of the multiple light sources.

[0039] Controlling the multiple light sources to illuminate the detection point according to the focusing information may include: processing the light illuminated by the multiple light sources according to the focusing information so that the processed light illuminates the detection point and passes through the detection point to illuminate the detected position of the target organ.

[0040] Obtaining the imaging of the target organ according to the first imaging information may include: combining the first imaging information with other imaging information (such as the second imaging information) to obtain the imaging of the target organ.

[0041] In this embodiment, the imaging ray may be a CT (Computed Tomography) ray.

[0042] In the embodiments of the present application, the sampling depth for microscopic tissue testing can be the sampling depth at which tissue samples are taken for magnified testing using a microscope. For example, when screening for tumors in a target organ, tissue samples are taken from the inner surface of the target organ. The microscopic tissue sampling depth is the depth at which the inner surface of the target organ is located. In this case, the distance from the outer surface to the inner surface of the target organ can be used as the target testing depth.

[0043] The embodiment of the present application controls multiple light sources to illuminate the target organ at a preset depth, thereby determining imaging at a certain depth inside the target organ, helping medical personnel to examine the target organ, understand the health status of the internal tissue of the target organ, and conduct effective pre-inspection of tissue lesions such as tumors.

[0044] In an embodiment of the present application, the imaging module may utilize a surface detector such as a CCD (charge-coupled device) to receive the first residual imaging radiation for imaging. A light beam from at least one of the spatial array light sources is first focused by a focusing element. At the target organ's detection location, the focused light creates a spot size that is smaller than the total size of the at least one light source, and the brightness of the spot is greater than the illumination brightness of a single light source. Light that passes through the target organ's detection location is collected in a direction perpendicular to the illumination surface, then passes through an imaging amplification element and reaches the surface detector CCD.

[0045] In one implementation of the present application, multiple light sources in the spatial array light source are located on different planes, and their corresponding surface detectors are also located on different planes. However, the irradiation focus of the multiple light sources located in different planes can be controlled to be on the detected position of the same target organ, ensuring that the obtained image is the detection result of the detected position of the same target organ. By adjusting the wave zone plate magnification size, local microscopic magnification of the detection is achieved. After the magnification is determined, the imaging pictures of multiple detectors can be synthesized. During the scanning process, the multiple X-ray sources and the corresponding surface detectors move synchronously while ensuring confocality.

[0046] In one embodiment, the multiple light sources are spatial array light sources located at different positions; the light source focus control module further includes:

[0047] an energy unit, configured to determine the energy of the imaging rays of the multiple light sources at a focus position according to the irradiation depth;

[0048] a quantity unit, configured to determine the light source to be activated in the spatial array light source according to the preset magnification, the imaging requirement for the detection target, and the dose of each light source in the multiple light sources;

[0049] A focusing unit is configured to determine focusing information of the multiple light sources according to the energy and the activated light sources in the spatial array light source.

[0050] In the embodiment of the present application, the focus position of the multiple light sources may include the position from the surface of the target organ to the deepest irradiation depth of the target organ. Figure 2As shown, it is assumed that the target organ is a target organ 201 of the human body, the target organ 201 is an organ located in a human body cavity (such as the abdominal cavity, thoracic cavity, pelvic cavity, etc.), the skin 202 is the skin tissue surrounding the human body cavity, and the outer surface of the skin 202 is the human body surface. The detection point 203 is located on the surface of the skin 202. The target detection depth of the target organ is h, corresponding to at least one deepest point 204 in the target organ 201. The focus position of the multiple light sources can include the position corresponding to the organ tissue from the deepest point 204 to the projection point 205 on the surface of the target organ 201 close to the skin 202.

[0051] Determining the energy of the imaging rays of the multiple light sources at the focus position according to the irradiation depth may include: determining the density of the target organ according to the type of the target organ, and determining the energy of the imaging rays of the multiple light sources at the focus position according to the density of the target organ.

[0052] The density of the target organ may include the density of normal tissue of the target organ and the density of tumor tissue of the target organ.

[0053] In this embodiment, the spatial array light source can be a plurality of light sources located in different planes in a three-dimensional space, and the plurality of light sources can be arranged into an array on a certain curved surface. In a possible implementation, for example Figure 3 As shown, the spatial array light source can be distributed within a cylindrical surface 301, with each light source 302 being an element of the spatial array, and multiple light sources forming a curved array distributed along the cylindrical surface 301. In the embodiments of the present application, the spatial array light source is not strictly arranged in rows or columns; multiple light sources can be arranged at different densities within a three-dimensional space, or the spatial array light source can include multiple sub-arrays of different densities, each sub-array including multiple light sources.

[0054] In another possible implementation, Figure 4 As shown, each light source included in the spatial array light source includes a light-emitting component 401 and an adjustment component 402. The adjustment component 402 is used to adjust the angle of the light-emitting component 401, as well as the extension and rotation of the adjustment component 402, based on received adjustment instructions. By sending adjustment instructions to each light source in the spatial array light source, the distance and angle of the spatial array light source can be adjusted.

[0055] In the embodiment of the present application, the illumination area of ​​each light source in the spatial array light source is N square micrometers, where N is a positive number.

[0056] In an embodiment of the present application, the imaging clarity can be adjusted by controlling the dose of each light source in the spatial array light source. Simultaneously, the imaging clarity can also be controlled by controlling the degree of overlap of the spatial array light sources. The focusing unit is configured to determine the focusing information of the multiple light sources based on the energy and the activated light sources in the spatial array light source, determine the focusing of the emitted light from each light source in the multiple light sources, and focus the emitted light from the multiple light sources in the spatial array light source onto the same detected location of the target organ, so that the imaging module obtains more first imaging information about the detected location of the target organ. The smaller area image generated by the first imaging information, after the smaller area image is magnified to obtain a larger area image, also contains sufficient and clear content in the larger area image, thereby achieving the effect of irradiating the detected location of the smaller area target organ and obtaining a larger area, clearer image. The spatial array light source can be divided into regions, and corresponding illuminated regions are determined for different target organs. Then, the activated light sources are determined within the illuminated regions.

[0057] In one embodiment, the imaging requirements include: a detection position of the target organ and shape parameters of the target organ; the energy unit is further configured to:

[0058] determining abnormal tissue of the target organ according to the preliminary scan information of the target organ;

[0059] determining the tumor type of the target organ according to the type of the target organ;

[0060] determining, based on the tumor type, markers produced in the target organ when the tumor appears;

[0061] determining the energy of the imaging ray according to the irradiation depth, the marker, and the abnormal tissue;

[0062] The quantity unit is also used for:

[0063] determining a lighting position of the spatial array light source according to a detection orientation of the target organ and shape parameters of the target organ;

[0064] The light source to be activated at each position is determined according to the preset magnification, the lighting position and the dose of each light source.

[0065] In this embodiment, the preliminary scan information may include images obtained by non-imaging rays such as ultrasound, such as ultrasound images, nuclear magnetic resonance images, etc.

[0066] Determining the abnormal tissue of the target organ based on the preliminary scan information of the target organ may include calculating or predicting parameters such as the size, depth, and shape of the abnormal tissue based on the preliminary scan information.

[0067] When tumors or other types of abnormal tissue appear in different organs of the human body, they will have different appearance characteristics. The benign or malignant nature of the tumor or other types of abnormal tissue will also affect the degree to which the tumor absorbs imaging radiation. In addition, when tumors appear in human organs, some tumors may cause the appearance of special proteins or compounds within the organ tissue, namely, the markers in the embodiments of this application. These markers may also cause the imaging radiation to be absorbed or transmitted, resulting in unique imaging characteristics. Therefore, when examining a target organ, the energy of the imaging radiation can be determined based on the type of tumor that may appear in the target organ and the markers produced when the tumor grows in the target organ, thereby accurately detecting the tumor or tumor markers, and thus accurately detecting the pathology of the target organ.

[0068] In one embodiment, the illumination module is further configured to:

[0069] generating a bunching instruction to bunch the light rays emitted by the multiple light sources to obtain bunched light rays;

[0070] generating a filtering instruction according to a filtering parameter, performing a filtering operation on the bundled light to obtain a filtered light; the filtering parameter is determined according to the target organ and the tumor type corresponding to the target organ; the filtering parameter may be pre-set according to the requirements for generating an image;

[0071] According to the detected position of the target organ, the irradiation area of ​​the filtered light is adjusted to obtain irradiation light;

[0072] The detection point is illuminated with the illumination light.

[0073] In this embodiment, Figure 5 As shown, the irradiation module includes a multi-source control unit 501, a high-voltage power supply unit 502, a target control unit 503, an X-ray source 504, a beam splitter 505, a filter 506, and a zone plate 507. The multi-source control unit 501 generates a multi-source control signal, which is used to activate some of the light sources in the spatial array. The high-voltage power supply unit 502 generates a current signal to activate some of the light sources. The target control unit 503 uses the current signal to excite the target, generating target particles. These particles combine with the electrode signal generated by the X-ray source 504 to generate X-rays. The beam splitter 505 bundles the light to produce bundled light. The filter 506 then filters the light to produce filtered light. Finally, the zone plate 507 adjusts the irradiation area of ​​the filtered light to produce the irradiation light directed at the target organ.

[0074] The filtering parameters of the filter 506 may be determined according to the target organ and the tumor type corresponding to the target organ, or the filter 506 may be used to filter noise signals in the X-ray.

[0075] The imaging device provided in the embodiments of this application adheres to the principles of geometric optics and employs an imaging module for both imaging and magnification. The imaging module functions as a lens in an optical microscope, thereby enabling magnified imaging of target organs using X-rays. Because X-rays have a very short wavelength and their refractive index at the interface of glass and general materials is close to 1, the embodiments of this application utilize a zone plate with adjustable magnification to adjust the irradiation area.

[0076] At the beginning of each scan, different target materials are first selected according to the composition of the measured tissue, and the radiation energy is selected by controlling the high-voltage power supply. The X-rays are emitted from the static X-ray source and the beam line. After the filter absorbs low-energy, non-specified wavelength X-rays and the magnification-adjustable wave plate focuses them, they are irradiated to the detected position of the target organ through the detection point; the emitted X-rays are collected by the wave zone plate, the filter filters out non-specified wavelength X-rays and stray light, and phase compensated, and then imaged multiple times by the high-speed area detector. After the image filtering and enhancement, a clear image is formed and the image is synthesized. The image is received by the control board and enters the host computer for analysis and calculation such as tumor recognition.

[0077] In another possible implementation, because the luminous area of ​​each light source is very small, approximately on the order of square micrometers, the original image size is also on the order of square micrometers. To more clearly observe the tissue structure of the target organ and determine whether a tumor is present in the target organ, the original image needs to be magnified. To amplify the original image sufficiently, the rays emitted by multiple light sources in the spatial array light source can be overlapped at the same focal position on the target organ. This ensures that the amount of radiation irradiating the same focal position is sufficient, and the remaining imaging rays at the same smaller focal position contain sufficient information. This allows the original image to be directly magnified by pixel, allowing for a more accurate determination of the presence of a tumor in the target organ.

[0078] Accordingly, in one implementation, after determining the light source to be started in the spatial array light source based on the imaging requirements of the detection target and the dosage of each light source in the multiple light sources, the quantity unit is also used to determine the supplementary light source in the spatial array light source based on a preset magnification and the light source currently determined to be started in the spatial array light source (relative to the supplementary light source, which can be called the main starting light source).

[0079] Therefore, in an embodiment of the present application, the spatial array light source includes a main starting light source and a supplementary light source for the main starting light source. The focal position of the supplementary light source coincides with the focal position of its corresponding main starting light source, so that the supplementary light source can supplement the focal position of the main starting light source with more imaging rays. In one possible implementation, the supplementary light source is a light source within a set range around the main starting light source. The same light source in the spatial array light source can serve as the main starting light source in one irradiation and as a supplementary light source in another irradiation.

[0080] In one embodiment, the imaging module is further configured to:

[0081] Obtaining pixel information of each pixel at the detected position of the target organ according to the remaining rays;

[0082] determining, based on the target organ and the tumor type of the target organ, a first predicted texture feature in all pixels at the detected position of the target organ when a tumor is present at the detected position of the target organ;

[0083] determining a linear interpolation direction according to the first predicted texture feature and the pixel information;

[0084] amplifying the pixel information according to the linear interpolation direction to obtain amplified pixel information;

[0085] The first imaging information is obtained according to the amplified pixel information.

[0086] When the target organ is known, the type of tumor that may appear in the target organ can also be determined based on the target organ. For example, when the target organ is the breast, the breast tumor may be a fibroadenoma, breast cancer, etc. Different types of tumors appearing in the same target organ may show different characteristics in the imaging, corresponding to different textures. At the same time, since the imaging size corresponding to each light source of the spatial array light source in the embodiment of the present application is on the order of square microns, the resulting imaging is difficult to directly observe with the naked eye. Therefore, the imaging is linearly interpolated and amplified according to the texture characteristics.

[0087] In one embodiment, determining the linear interpolation direction according to the first texture feature includes:

[0088] determining a second predicted texture feature of the image of the detected position of the target organ based on the pixel information;

[0089] A linear interpolation direction is determined according to the first predicted texture feature and the second predicted texture feature, so that the amplified pixel information covers the pixels corresponding to the first predicted texture feature and the pixels corresponding to the second predicted texture feature.

[0090] Determining a second predicted texture feature of the image of the detected position of the target organ based on the pixel information includes: determining a first pixel point whose imaging color depth difference is less than a preset threshold; and determining the second predicted texture feature based on a distribution feature of the first pixel point.

[0091] Determining a linear interpolation direction according to the first predicted texture feature and the second predicted texture feature includes: Figure 6 As shown in a in FIG, when the similarity between the first predicted texture feature 601 and the second predicted texture feature 602 is greater than a preset threshold, the extension direction of the first predicted texture feature 601 is used as the linear interpolation direction; Figure 6 As shown in b, when the similarity between the first predicted texture feature 601 and the second predicted texture feature 602 is less than a preset threshold, the image is divided into a plurality of elongated and mutually parallel rectangular areas, and linear interpolation is performed along the direction of the rectangular areas.

[0092] In one embodiment, the light source focus control module is further configured to:

[0093] Determining a new light irradiation direction based on the first imaging information and the preset magnification; updating the number of light sources activated at each position in the spatial array light source based on the new light irradiation direction, the energy, and the dose; updating focusing information of the multiple light sources based on the energy and the updated number; and triggering the irradiation module to irradiate the detection point based on the updated focusing information;

[0094] The imaging module is further configured to obtain second imaging information of the tomography scan based on a second remaining imaging ray passing through the detected position of the target organ; and obtain imaging information of the target organ based on the first imaging information and the second imaging information.

[0095] Before the light source focus control module determines a new light irradiation direction according to the first imaging information, it further executes: turning off the multiple light sources to minimize the amount of light irradiated to the patient's body.

[0096] In an embodiment of the present application, determining a new light irradiation direction based on the first imaging information includes: determining reference imaging information of normal tissue of the target organ; wherein the reference imaging information of the normal tissue of the target organ includes imaging information generated by imaging radiation irradiation of the normal tissue of the target organ; determining the similarity between the first imaging information and the reference imaging information, and when the similarity is less than a set threshold, determining a new light irradiation direction based on the original focus position; when the similarity is greater than the set threshold, selecting other positions other than the original focus position, and determining a new light irradiation direction based on the newly selected other positions.

[0097] In this embodiment, the light source focusing control module and the imaging module focus, irradiate multiple times and linearly interpolate the light from multiple light sources, so that the imaging device can perform radiographic imaging of the detected position of the target organ, and achieve the effect of microscope-magnified biopsy tissue imaging through radiographic imaging.

[0098] In one implementation, the light source focusing control module amplifies the image information of the detected position of the target organ at least once by focusing the light and irradiating multiple times according to a preset magnification factor, and the imaging module amplifies the image information of the detected position of the target organ at least once by linear interpolation according to a preset magnification factor. Thus, through at least triple amplification, the image information of the detected position of the target organ is amplified, and an effect similar to that of detecting biopsy tissue with a microscope is achieved using imaging rays.

[0099] By using a spatial array light source for focused irradiation and multiple scanning operations, the imaging device in the embodiment of the present application can gather all the information required for imaging and amplification at one time, thereby reducing the time the patient is examined and reducing the pain the patient suffers during the examination.

[0100] Before the light source focusing control module determines the focusing information, the imaging device can also perform a magnification task allocation operation according to a preset magnification factor, determine an estimated number of scans, and determine a first magnification factor for magnification through the light source focusing operation and a second magnification factor for magnification through the linear interpolation operation during each scan based on the estimated number of scans. Then, the light source focusing control module determines the focusing information of the multiple light sources based on the first magnification factor and the irradiation depth. After determining the linear interpolation direction, the imaging module amplifies the pixel information according to the second magnification factor to obtain the amplified pixel information.

[0101] During a single scan, the magnification factor applied to the target organ's location is equal to the product of the first magnification factor and the second magnification factor. After multiple scans, the magnification factor applied to the target organ's location is equal to the sum of the magnification factors of the multiple scans. By controlling the first and second magnification factors during each scan, the sum of the magnification factors of the multiple scans is approximately equal to the preset magnification factor. This allows imaging through radiographic imaging to achieve the equivalent effect of performing a biopsy on the target organ's location, while avoiding the need to collect biopsy tissue from the target organ, reducing pain for the patient during the test.

[0102] Obtaining imaging information of the target organ based on the first imaging information and the second imaging information may also include: determining existing imaging information based on the first imaging information and the second imaging information; judging whether to perform the next scan based on the existing imaging information and the estimated number of scans; if it is determined that the next scan is to be performed, re-entering the step of determining a new light irradiation direction based on the existing imaging information and the preset magnification, then executing subsequent steps to obtain new second imaging information, updating the existing imaging information based on the new second imaging information, and returning to the step of judging whether to perform the next scan based on the existing imaging information and the estimated number of scans; if it is determined that the next scan step is not to be performed, obtaining imaging information of the target organ based on the existing imaging information.

[0103] In one embodiment, the imaging module comprises:

[0104] a photoelectric signal generating unit, configured to receive the remaining imaging rays through a charge-coupled device sensor, so that the charge-coupled device sensor generates a photoelectric signal; the charge-coupled device sensor is located in a plane corresponding to the light source of the remaining imaging rays;

[0105] an imaging signal unit, configured to integrate the photoelectric signal in a time dimension for a unit imaging area included in the detected position of the target organ to obtain an imaging signal for the unit imaging area;

[0106] A signal splicing unit, used for splicing imaging signals of all unit imaging areas to obtain a splicing signal;

[0107] An imaging information unit is configured to obtain the imaging information according to the spliced ​​signal.

[0108] In one embodiment, the imaging information unit is further configured to:

[0109] determining, according to the illumination direction of each of the activated light sources, an angle between an imaging plane of a sub-image corresponding to each light source and a horizontal plane in a three-dimensional imaging space;

[0110] determining, based on the energy of each of the activated light sources, a height of an imaging plane of a sub-image corresponding to each of the light sources relative to a horizontal plane in a three-dimensional imaging space;

[0111] Determining a sub-image of each light source according to the included angle and the height;

[0112] The sub-images corresponding to each light source among the activated light sources are spliced ​​in the three-dimensional imaging space to obtain the spliced ​​signal.

[0113] The embodiment of the present application uses confocal multi-radiation source micro-CT technology (i.e., microscopic imaging technology) to magnify and image microscopic structures and graphics that are invisible to the naked eye for observation and research, providing support for early diagnosis of tumors.

[0114] In one example of this application, Figure 7 As shown in FIG, the imaging device can be divided into a transmitting component, an imaging component, a focusing component, a control board and a host computer. Among them, the structure of the transmitting component can refer to Figure 5 As shown, it is equivalent to implementing Figure 1 The functions of the illumination module and related embodiments shown. The imaging component can be used to implement Figure 1 The functions of the imaging module and related embodiments shown in Figure 5 Based on the example shown, the imaging component is used to process the imaging rays received by the CCD and finally output an image. The focusing component may include Figure 8 The structure shown in the figure uses a 3D mechanical control unit and an adaptive focus unit to perform coarse focus adjustment, an image comparison and synthesis unit to readjust focus information to perform multiple scans, and a 3D manual fine adjustment unit to perform fine focus adjustment.

[0115] Various aspects of the apparatus described herein can be implemented as functions programmed into any of a variety of circuits, including programmable logic devices (PLDs), such as field programmable gate arrays (FPGAs), programmable array logic (PAL) devices, electronic programmable logic and memory devices, standard cell-based devices, and application-specific integrated circuits (ASICs). Some other possibilities for implementing these aspects of the system include: microcontrollers with memory, such as electronically erasable programmable read-only memory (EEPROM), embedded microprocessors, firmware, software, etc. In addition, these aspects of the system can be embodied in microprocessors with software-based circuit simulation, discrete logic (sequential and combinational), custom devices, fuzzy (neural) logic, quantum devices, and any combination of the various device types mentioned above. Of course, the underlying device technology can be provided in a variety of component types, such as metal oxide semiconductor field effect transistor (MOSFET) technology such as complementary metal oxide semiconductor (CMOS), bipolar technology such as emitter coupled logic (ECL), polymer technology (e.g., silicon conjugated polymer and metal conjugated polymer metal structures), hybrid analog and digital, etc.

[0116] The various functions or processes disclosed herein may be described as data and / or instructions embodied in various computer-readable media in terms of their behavior, register transfers, logic components, transistors, geometric layouts, and / or other characteristics. Computer-readable media that may contain such formatted data and / or instructions include, but are not limited to, various forms of non-volatile storage media (e.g., optical, magnetic, or semiconductor storage media) and carrier waves that may be used to transmit such formatted data and / or instructions via wireless, optical, or wired signal media, or any combination thereof. When received in any of the various circuits (e.g., computers), such data and / or instructions may be processed by a processing entity (e.g., one or more processors).

[0117] The above description of the illustrated embodiments of the systems and methods is not intended to be exhaustive or to limit the systems and methods to the precise forms disclosed. Although specific embodiments and examples of the systems, components, and methods are described herein for illustrative purposes, it will be understood by those skilled in the art that various equivalent modifications are possible within the scope of the systems, components, and methods. The teachings of the systems and methods provided herein may be applied to other processing systems and methods, not just the systems and methods described above.

[0118] Those skilled in the art will appreciate that many variations and / or modifications may be made to the invention shown in the specific embodiments without departing from the spirit or scope of the invention as broadly described. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive. Furthermore, the present invention encompasses any combination of features described with respect to the various embodiments (including those in the Abstract), even if such feature or combination of features is not expressly provided for in the claims or the detailed description of the embodiments.

[0119] In general, in the following claims, the terms used should not be construed to limit the systems and methods to the specific embodiments disclosed in the specification and claims, but should be construed to include all processing systems that operate under the claims. Accordingly, the systems and methods are not limited by the present disclosure, but rather the scope of the systems and methods is determined entirely by the claims.

[0120] Throughout the specification and claims, unless the context clearly requires otherwise, the words “include,” “comprising,” and the like are to be interpreted in an inclusive sense and not in an exclusive or exhaustive sense; that is, in the sense of “including but not limited to.” Words using the singular or plural number also include the singular or plural number, respectively. In addition, “herein,” “hereinafter,” “above,” “hereafter,” and words of similar meaning refer to this application as a whole and not to any particular parts of this application. When the word “or” is used in a list involving two or more items, the word “or” includes all of the following interpretations of the word: any item in the list, all items in the list, and any combination of items in the list.

[0121] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature identified as "first" or "second" may explicitly or implicitly include one or more of the features. Throughout the description of this application, "plurality" means more than two, unless otherwise specifically defined.

[0122] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent replacements, and improvements made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. An imaging device, characterized in that: include: A position information acquisition module, used to obtain the position information of the target organ; The position information includes the position of the detection point corresponding to the target organ on the human body surface, and the distance between the detected position of the target organ and the detection point; an irradiation depth determination module, configured to determine the irradiation depth of the imaging radiation from the detection point into the human body according to the position of the detection point and a target detection depth; the target detection depth is determined according to the sampling depth of a biopsy tissue sample taken during microscopic examination of the target organ; A light source focusing control module, configured to determine focusing information of the multiple light sources according to a preset magnification and the irradiation depth; the preset magnification being the magnification used when performing microscopic examination of biopsy tissue of the target organ; an irradiation module, configured to control the multiple light sources to generate imaging rays according to the focusing information, so as to irradiate the detection point; An imaging module is configured to obtain first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and to obtain an image of the target organ based on the first imaging information.

2. The device according to claim 1, characterized in that The multiple light sources are spatial array light sources located at different positions; The light source focusing control module further includes: an energy unit, configured to determine the energy of the imaging rays of the multiple light sources at a focus position according to the irradiation depth; a quantity unit, configured to determine the light source to be activated in the spatial array light source according to the preset magnification, the imaging requirement for the target organ, and the dose of each light source in the multiple light sources; A focusing unit is configured to determine focusing information of the multiple light sources according to the energy and the activated light sources in the spatial array light source.

3. The device according to claim 2, characterized in that The imaging requirements include: the detection position of the target organ and the shape parameters of the target organ; the energy unit is further used to: determining abnormal tissue of the target organ according to the preliminary scan information of the target organ; determining the tumor type of the target organ according to the type of the target organ; determining, based on the tumor type, markers produced in the target organ when the tumor appears; determining the energy of the imaging ray according to the irradiation depth, the marker, and the abnormal tissue; The quantity unit is also used for: Determining the lighting position of the spatial array light source according to the preset magnification, the detection orientation of the target organ, and the shape parameters of the target organ; The light source to be activated at each position is determined according to the lighting position and the dose of each light source.

4. The device according to claim 1, characterized in that The irradiation module is further used for: generating a bunching instruction to bunch the light rays emitted by the multiple light sources to obtain bunched light rays; generating a filtering instruction according to a filtering parameter, performing a filtering operation on the bundled light to obtain a filtered light; wherein the filtering parameter is determined according to the target organ and the tumor type corresponding to the target organ; According to the detected position of the target organ, the irradiation area of ​​the filtered light is adjusted to obtain irradiation light; The detection point is illuminated with the illumination light.

5. The device according to claim 1, characterized in that The imaging module is further configured to: obtaining pixel information of each pixel of the detected position of the target organ according to the first remaining imaging ray; determining, based on the target organ and the tumor type of the target organ, a first predicted texture feature in all pixels at the detected position of the target organ when a tumor is present at the detected position of the target organ; determining a linear interpolation direction according to the first predicted texture feature and the pixel information; amplifying the pixel information according to the linear interpolation direction to obtain amplified pixel information; The first imaging information is obtained according to the amplified pixel information.

6. The device according to claim 5, characterized in that The step of determining a linear interpolation direction according to the first predicted texture feature includes: determining a second predicted texture feature of the image of the detected position of the target organ based on the pixel information; A linear interpolation direction is determined according to the first predicted texture feature and the second predicted texture feature, so that the amplified pixel information covers the pixels corresponding to the first predicted texture feature and the pixels corresponding to the second predicted texture feature.

7. The device according to any one of claim 2, characterized in that The light source focusing control module is also used for: Determining a new light irradiation direction based on the first imaging information and the preset magnification; updating the number of light sources activated at each position in the spatial array light source based on the new light irradiation direction, the energy, and the dose; updating focusing information of the multiple light sources based on the energy and the updated number; and triggering the irradiation module to irradiate the detection point based on the updated focusing information; The imaging module is further configured to obtain second imaging information of the tomography scan based on a second remaining imaging ray passing through the detected position of the target organ; and obtain imaging information of the target organ based on the first imaging information and the second imaging information.

8. The device according to claim 2, characterized in that The imaging module includes: a photoelectric signal generating unit, configured to receive the remaining imaging rays through a charge-coupled device sensor, so that the charge-coupled device sensor generates a photoelectric signal; the charge-coupled device sensor is located in a plane corresponding to a light source of the remaining imaging rays; an imaging signal unit, configured to integrate the photoelectric signal in a time dimension for a unit imaging area included in the detected position of the target organ to obtain an imaging signal for the unit imaging area; A signal splicing unit, configured to splice the imaging signals of all unit imaging areas to obtain a spliced ​​signal; An imaging information unit is configured to obtain the imaging information according to the spliced ​​signal.

9. The device according to claim 8, characterized in that The imaging information unit is further used for: determining, according to the illumination direction of each of the activated light sources, an angle between an imaging plane of a sub-image corresponding to each light source and a horizontal plane in a three-dimensional imaging space; determining, based on the energy of each of the activated light sources, a height of an imaging plane of a sub-image corresponding to each of the light sources relative to a horizontal plane in a three-dimensional imaging space; Determining a sub-image of each light source according to the included angle and the height; The sub-images corresponding to each light source among the activated light sources are spliced ​​in the three-dimensional imaging space to obtain the spliced ​​signal.

10. A non-transitory computer-readable storage medium storing computer instructions, wherein: The computer instructions are used to cause the computer to execute the steps executed by the apparatus according to any one of claims 1 to 9.

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