A pharmaceutical composition for repairing tumors and treating myocardial damage and its preparation method

Abstract

The present invention belongs to the field of preparation of drugs for repairing myocardial damage, and in particular relates to a pharmaceutical composition for repairing myocardial damage for tumor treatment and its preparation method. Mixed herbal powder is fumigated with water vapor in a medicine steamer to reduce its toxicity, and is combined with a taste improver made by pulping hawthorn and red dates, and a nerve-soothing compound liquid obtained by vacuum boiling, and is pressed into lozenges using a tablet press; the lozenges are soaked and coated with pore-containing rice starch to make the drug more stable, exert its efficacy faster, and reduce damage to the stomach. The prepared pharmaceutical composition for repairing myocardial damage for tumor treatment can maintain the left ventricular pumping function of mice with myocardial infarction models, effectively repair myocardial cell damage in mice after tumor treatment, and maintain the troponin content at 0.063 ng / mL and the myoglobin content at 68.7 ng / mL.

Description

Technical Field

[0001] The present invention belongs to the field of preparation of drugs for repairing myocardial damage, and specifically refers to a drug composition for repairing myocardial damage caused by tumors and a preparation method thereof. Background Art

[0002] Tumor treatment includes surgery, chemotherapy, targeted therapy, and immunotherapy. The myocardium will be damaged to varying degrees during the process. Surgical treatment stimulates the heart and causes arrhythmias. The large dose of radiotherapy will affect the pericardium and eventually form pericarditis. The radioactive substances in it will damage the myocardium and cause myocardial fibrosis. Chemotherapy drugs can directly damage myocardial cells, leading to weakened heart muscle function, heart failure, and decreased heart pumping function. Targeted drugs can precisely treat tumor cells, but will reduce the left ventricular ejection fraction of the heart and tachycardia causing hypertension, myocardial infarction, and angina pectoris.

[0003] Tumor immunotherapy uses PD-1 and PD-L1 immunosuppressants to promote the proliferation and activation of T cells, enhance their ability to recognize tumor cells, and strengthen their ability to attack and kill tumor cells. PD-1 and PD-L1 are also expressed in cardiomyocytes, so immunotherapy drugs can have direct toxic effects on the heart, leading to arrhythmias, myocarditis, and heart failure.

[0004] At present, the existing drug preparation technology for repairing myocardial damage after tumor treatment has the following main problems: First, the drug tastes bad, and the ingredients it contains irritate the gastrointestinal tract, causing symptoms of nausea, vomiting, and diarrhea. Long-term use of myocardial repair drugs causes the sympathetic nerves to be in a state of excitement for a long time, causing headaches, unstable blood pressure, and damage to the nervous system; Second, the drug is poorly absorbed and easily develops drug resistance. Continuously increasing the dosage will burden the liver and kidneys, leading to renal failure, imbalance of the body's internal environment, and destruction of the normal living environment of myocardial cells; Third, allergic reactions occur after taking the drug, resulting in symptoms of skin redness, swelling, itching, difficulty breathing, and local edema. Summary of the Invention

[0005] In view of the above situation, in order to overcome the defects of the existing technology, the present invention provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. In order to solve the problems that existing drugs for repairing myocardial damage after tumor treatment stimulate the gastrointestinal tract, damage the function of the nervous system, burden the liver and kidneys, and destroy the internal environment of the body, the present invention uses a taste improver and a nerve-soothing compound liquid mixed with steamed Chinese herbal medicines. The prepared pharmaceutical composition for repairing tumors and treating myocardial damage does not stimulate the gastrointestinal tract, soothes the nervous system, has a significant effect on repairing myocardial cells, and maintains a stable internal environment of the body.

[0006] In order to achieve the above-mentioned object, the technical solution adopted by the present invention is as follows: the present invention proposes a pharmaceutical composition for repairing tumors and treating myocardial damage, comprising the following components in parts by weight:

[0007] 150-280 parts of Astragalus, 130-180 parts of Chuanxiong, 100-145 parts of Rehmannia root, 80-120 parts of Dragon bone, 75-110 parts of Poria, 60-70 parts of Psoralea corylifolia, 40-55 parts of Black Fungus, 60-75 parts of taste improver, 160-190 parts of nerve soothing compound liquid, 100-120 parts of rice starch, 15-18 parts of sodium bicarbonate, and 130-150 parts of ultrapure water.

[0008] Preferably, the taste improver specifically includes: hawthorn and red dates.

[0009] Furthermore, the preparation method of the mouthfeel improver specifically comprises the following steps:

[0010] S1. Weigh 140-160 parts by weight of hawthorn and 50-80 parts of red dates and put them into a pitting machine with a power of 2-3 kW. The pitting temperature is 20-25° C. and the pitting time is 20-25 min. The pitting is performed to obtain pitted hawthorn and pitted red dates;

[0011] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.5-1.8 kW grinder at a grinding temperature of 23-26° C. for 35-45 min to obtain a hawthorn and red date mixture;

[0012] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 5-8 kW, the beating temperature is, the beating time is 25-30°C, and the beating time is 25-30 min to obtain a taste improver.

[0013] Preferably, the nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, wild jujube seeds, and ultrapure water.

[0014] Furthermore, the preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0015] L1. Weigh 60-70 parts by weight of mulberry leaves, 40-60 parts of cassia seeds, 20-30 parts of spinach seeds, and 500-600 parts of ultrapure water, and place them in a vacuum cooker with a power of 18-22 kW, and cook at a vacuum degree of -0.08-0 MPa at a temperature of 120-135° C. for 15-20 minutes to obtain a nerve-soothing composition;

[0016] L2. Place the nerve-soothing composition prepared in L1 into a filter with a power of 2-3 kW and a filtration accuracy of 5-10 mm, filter and remove the residue to obtain a high-temperature nerve-soothing compound solution;

[0017] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant-temperature stainless steel barrel at a temperature of 18-22°C for 1.2-1.5 hours to obtain the nerve-soothing compound liquid.

[0018] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0019] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them into powder in a powder grinder to obtain mixed herbal powder;

[0020] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 50-200 mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0021] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a medicine steaming machine and steam it to obtain steamed mixed Chinese herbal medicine powder;

[0022] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, put them into a blender, and stir to obtain a drug mixture for treating myocardial injury;

[0023] Step 5: placing the drug mixture for treating myocardial injury prepared in step 4 into a tablet press, and compressing the tablets to obtain tablets for treating myocardial injury;

[0024] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 75-85°C, rotate at 60-80 r / min, stir for 12-13 minutes, then cool to 30-33°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 20-30 seconds, and then remove to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0025] Step 7: Place the wet pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a dryer for drying to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0026] Preferably, in step 1, the power of the powder pulverizer is 3-4 kW, the powder pulverizing temperature is 20-25° C., and the powder pulverizing time is 1.3-1.6 h.

[0027] Preferably, in step three, the power of the medicine steaming machine is 3.3-3.6 kW, the steam pressure is 93-98 kPa, the medicine steaming temperature is 110-115° C., and the medicine steaming time is 40-45 min.

[0028] Preferably, in step 4, the stirrer power is 2.5-4 kW, the stirring temperature is 25-28° C., the stirring speed is 110-130 r / min, and the stirring time is 30-40 min.

[0029] Preferably, in step five, the tablet press has a power of 2.2-2.5 kW, a tableting pressure of 10-12 kN, a tableting diameter of 7-10 mm, a tableting temperature of 30-35° C., and a tableting time of 1.2-1.6 h.

[0030] Preferably, in step seven, the dryer power is 1.6-3.2 kW, the drying temperature is 28-30° C., and the drying time is 15-20 min.

[0031] The beneficial effects achieved by the present invention are as follows:

[0032] The present invention proposes to mix astragalus, Chuanxiong, Rehmannia root, dragon bone, Poria, Psoralea corylifolia and black fungus. Astragalus contains astragaloside and astragalin, which can increase the heart's stroke volume, dilate coronary arteries and increase coronary blood flow. The ligustrin and ligustrazine in Chuanxiong can promote cardiac blood circulation, relieve cardiac ischemia and hypoxia, provide nutrients for myocardial cells, and promote myocardial cell proliferation and repair. The psoralen in Psoralea corylifolia, the iron in black fungus and the rehmannia polysaccharide in Rehmannia root can promote blood circulation. The synergistic effect of Astragalus, Chuanxiong, Psoralea corylifolia, Black Fungus and Rehmannia root can repair myocardial cell damage caused by heart failure, arrhythmia and myocardial ischemia after tumor treatment. Dragon bone is rich in unsaturated fatty acids and vitamins. The pachymic acid and triterpenoid components in Poria can improve myocardial structure and function, reduce myocardial cell death and myocardial fibrosis, and enhance the excretion function of the heart. Hawthorn can enhance the blood supply of the myocardium and its ability to resist hypoxia. Red dates contain cyclic Adenosine phosphate increases myocardial oxygen supply and accelerates myocardial cell metabolism, not only speeding up myocardial cell repair, but the blend of the two creates a flavor enhancer that gives the drug a sweet and sour taste, alleviating nausea and vomiting. Astragalus, Chuanxiong, and Poria also maintain the normal functioning of the renin-angiotensin-aldosterone system in the kidneys, supporting the normal secretion of erythropoietin and prostaglandins, regulating blood pressure and water-electrolyte balance, and maintaining a stable myocardial cell living environment. Gamma-aminobutyric acid in mulberry leaves, cassia bark extract in cassia seeds, and jujubeline in jujube seeds adjust the balance of neurotransmitters, reducing cerebral cortical excitability and preventing drug dependence. Steam fumigation of the finely mixed herbal powder destroys the drug's enzymes, reducing toxicity and side effects, and eliminating the burden on the liver and kidneys. Porous rice starch is used to coat the lozenges, making the drug more stable at room temperature, enabling faster efficacy, while controlling its release rate to minimize stomach damage and alleviate immune system stimulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the present invention or the technical solutions in the prior art, the following will be described in a clear and easy-to-understand manner with reference to the accompanying drawings. Obviously, the drawings described below are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0034] Figure 1 This is a graph showing the left ventricular ejection fraction of mice described in Experimental Example 1 of the present invention;

[0035] Figure 2 This is a graph showing the results of the troponin content in mouse myocardial cells described in Experimental Example 2 of the present invention;

[0036] Figure 3This is a graph showing the myoglobin content in mouse myocardial cells as described in Experimental Example 2 of the present invention;

[0037] Figure 4 This is a graph showing the enzyme activity results of mouse myocardial cells described in Experimental Example 2 of the present invention. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those familiar to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred embodiments and materials described herein are for illustrative purposes only and are not intended to limit the scope of this application.

[0040] The experimental methods in the following examples, unless otherwise specified, are conventional methods; the test materials and test strains used in the following examples, unless otherwise specified, are purchased from commercial channels.

[0041] Example 1: This example provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. The pharmaceutical composition for repairing tumors and treating myocardial damage comprises the following components in parts by weight:

[0042] 150 parts of Astragalus, 130 parts of Chuanxiong, 100 parts of Rehmannia root, 80 parts of Dragon bone, 75 parts of Poria, 60 parts of Psoralea corylifolia, 40 parts of Black Fungus, 60 parts of taste improver, 160 parts of nerve soothing compound liquid, 100 parts of rice starch, 15 parts of sodium bicarbonate, and 130 parts of ultrapure water.

[0043] The taste improver specifically includes: hawthorn and red dates.

[0044] The preparation method of the mouthfeel improver specifically comprises the following steps:

[0045] S1. Weighing 140 parts by weight of hawthorn and 50 parts of red dates into a 2 kW pitting machine, setting the pitting temperature at 20° C. for 20 min to obtain pitted hawthorn and pitted red dates;

[0046] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.5 kW grinder at a grinding temperature of 23° C. for 35 min to obtain a hawthorn and red date mixture;

[0047] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 5 kW, the beating temperature is, the beating time is 25°C, and the beating time is 25 min, and beat to obtain a taste improver.

[0048] The nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, jujube seeds, and ultrapure water.

[0049] The preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0050] L1. Weigh 60 parts by weight of mulberry leaves, 40 parts of cassia seeds, 20 parts of spinach seeds, and 500 parts of ultrapure water, and place them in an 18 kW vacuum cooker with a vacuum degree of -0.08 MPa at a temperature of 120° C. for 15 minutes to obtain a nerve-soothing composition.

[0051] L2, placing the nerve-soothing composition prepared in L1 into a filter with a power of 2 kW and a filtration accuracy of 5 mm, filtering and removing the filter residue to obtain a high-temperature nerve-soothing composite solution;

[0052] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant-temperature stainless steel barrel at 18°C ​​for 1.2 h to obtain the nerve-soothing compound liquid.

[0053] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0054] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them in a 3 kW grinder at 20°C for 1.3 h to obtain a mixed herbal powder;

[0055] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 50-mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0056] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a steaming machine with a power of 3.3 kW, a steam pressure of 93 kPa, a steaming temperature of 110° C., and a steaming time of 40 min, and steam the mixture to obtain steamed mixed Chinese herbal medicine powder;

[0057] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, place the mixture in a 2.5 kW blender, stir at a temperature of 25° C., a speed of 110 r / min, and a stirring time of 30 min, and mix to obtain a drug mixture for treating myocardial injury;

[0058] Step 5: Place the drug mixture for treating myocardial injury prepared in step 4 into a tablet press with a power of 2.2 kW, a tableting pressure of 10 kN, a tableting diameter of 7 mm, a tableting temperature of 30° C., and a tableting time of 1.2 h to obtain tablets for treating myocardial injury;

[0059] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 75°C, rotate at 60 r / min, stir for 12 minutes, then cool to 30°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 20 seconds, and then remove from the mixture to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0060] Step 7: Place the moistened pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a 1.6kW dryer for drying at a temperature of 28°C for 15 minutes to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0061] Example 2: This example provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. The pharmaceutical composition for repairing tumors and treating myocardial damage comprises the following components in parts by weight:

[0062] 220 parts of Astragalus, 160 parts of Chuanxiong, 125 parts of Rehmannia root, 100 parts of Dragon Bone, 100 parts of Poria, 65 parts of Psoralea corylifolia, 50 parts of Black Fungus, 70 parts of taste improver, 170 parts of nerve soothing compound liquid, 110 parts of rice starch, 17 parts of sodium bicarbonate, and 140 parts of ultrapure water.

[0063] The taste improver specifically includes: hawthorn and red dates.

[0064] The preparation method of the mouthfeel improver specifically comprises the following steps:

[0065] S1. Weigh 150 parts by weight of hawthorn and 70 parts of red dates and put them into a 2.5 kW pitting machine at a pitting temperature of 23° C. for 22 min to obtain pitted hawthorn and pitted red dates;

[0066] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.7 kW grinder at a grinding temperature of 25° C. for 40 min to obtain a hawthorn and red date mixture;

[0067] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 7 kW, the beating temperature is, the beating time is 28°C, and the beating time is 27 min, and beat to obtain a taste improver.

[0068] The nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, jujube seeds, and ultrapure water.

[0069] The preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0070] L1. Weigh 65 parts by weight of mulberry leaves, 50 parts by weight of cassia seeds, 25 parts by weight of spinach seeds, and 550 parts by weight of ultrapure water, and place them in a 20 kW vacuum cooker with a vacuum degree of -0.04 MPa at a temperature of 130° C. for 18 minutes to obtain a nerve-soothing composition.

[0071] L2, placing the nerve-soothing composition prepared in L1 into a filter with a power of 2.5 kW and a filtration accuracy of 8 mm, filtering and removing the filter residue to obtain a high-temperature nerve-soothing composite solution;

[0072] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant-temperature stainless steel barrel at 20°C for 1.4 hours to obtain the nerve-soothing compound liquid.

[0073] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0074] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them in a 3.5 kW grinder at a temperature of 22° C. for 1.5 h to obtain a mixed herbal powder;

[0075] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 100-mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0076] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a steaming machine with a power of 3.5 kW, a steam pressure of 96 kPa, a steaming temperature of 113° C., and a steaming time of 42 min, and steam the mixture to obtain steamed mixed Chinese herbal medicine powder;

[0077] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, place the mixture in a 3.5 kW blender, stir at a temperature of 27° C., a speed of 120 r / min, and a stirring time of 35 min, and mix to obtain a drug mixture for treating myocardial injury;

[0078] Step 5: Place the drug mixture for treating myocardial injury prepared in step 4 into a tablet press with a power of 2.4 kW, a tableting pressure of 11 kN, a tableting diameter of 9 mm, a tableting temperature of 34° C., and a tableting time of 1.5 h to obtain tablets for treating myocardial injury;

[0079] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 80°C, rotate at 70 r / min, stir for 12 minutes, then cool to 32°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 25 seconds, and then remove to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0080] Step 7: Place the moistened pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a 2.8 kW dryer for drying at a temperature of 29° C. for 18 minutes to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0081] Example 3: This example provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. The pharmaceutical composition for repairing tumors and treating myocardial damage comprises the following components in parts by weight:

[0082] 280 parts of Astragalus, 180 parts of Chuanxiong, 145 parts of Rehmannia root, 120 parts of Dragon bone, 110 parts of Poria, 70 parts of Psoralea corylifolia, 55 parts of Black Fungus, 75 parts of taste improver, 190 parts of nerve soothing compound liquid, 120 parts of rice starch, 18 parts of sodium bicarbonate, and 150 parts of ultrapure water.

[0083] The taste improver specifically includes: hawthorn and red dates.

[0084] The preparation method of the mouthfeel improver specifically comprises the following steps:

[0085] S1. Weigh 160 parts by weight of hawthorn and 80 parts of red dates and put them into a pitting machine with a power of 3 kW. The pitting temperature is 25° C. and the pitting time is 25 min. The pitting is performed to obtain pitted hawthorn and pitted red dates.

[0086] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.8 kW grinder at a grinding temperature of 26° C. for 45 min to obtain a hawthorn and red date mixture;

[0087] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 8 kW, the beating temperature is, the beating time is 30°C, and the beating time is 30 min, and beat to obtain a taste improver.

[0088] The nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, jujube seeds, and ultrapure water.

[0089] The preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0090] L1. Weigh 70 parts by weight of mulberry leaves, 60 parts of cassia seeds, 30 parts of spinach seeds, and 600 parts of ultrapure water, and place them in a 22 kW vacuum cooker with a vacuum degree of 0 MPa at a temperature of 135° C. for 20 minutes to obtain a nerve-soothing composition.

[0091] L2, placing the nerve-soothing composition prepared in L1 into a filter with a power of 3 kW and a filtration accuracy of 10 mm, filtering and removing the filter residue to obtain a high-temperature nerve-soothing composite solution;

[0092] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant temperature stainless steel barrel at 22°C for 1.5 hours to obtain the nerve-soothing compound liquid.

[0093] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0094] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them in a 4 kW grinder at a temperature of 25° C. for 1.6 h to obtain a mixed herbal powder;

[0095] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 200-mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0096] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a steaming machine with a power of 3.6 kW, a steam pressure of 98 kPa, a steaming temperature of 115° C., and a steaming time of 45 min, and steam the mixture to obtain steamed mixed Chinese herbal medicine powder;

[0097] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, place the mixture in a 4 kW blender, stir at a temperature of 28° C., a speed of 130 r / min, and a stirring time of 40 min, and mix to obtain a drug mixture for treating myocardial injury;

[0098] Step 5: Place the drug mixture for treating myocardial injury prepared in step 4 into a tablet press with a power of 2.5 kW, a tableting pressure of 12 kN, a tableting diameter of 10 mm, a tableting temperature of 35° C., and a tableting time of 1.6 h to obtain tablets for treating myocardial injury;

[0099] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 85°C, rotate at 80 r / min, stir for 13 minutes, then cool to 33°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 30 seconds, and then remove to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0100] Step 7: Place the moistened pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a 3.2kW dryer for drying at a temperature of 30°C for 20 minutes to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0101] Example 4: This example provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. The pharmaceutical composition for repairing tumors and treating myocardial damage comprises the following components in parts by weight:

[0102] 200 parts of Astragalus, 150 parts of Chuanxiong, 120 parts of Rehmannia root, 90 parts of Dragon bone, 90 parts of Poria, 63 parts of Psoralea corylifolia, 45 parts of Black Fungus, 65 parts of taste improver, 165 parts of nerve soothing compound liquid, 105 parts of rice starch, 16 parts of sodium bicarbonate, and 135 parts of ultrapure water.

[0103] The taste improver specifically includes: hawthorn and red dates.

[0104] The preparation method of the mouthfeel improver specifically comprises the following steps:

[0105] S1. Weighing 145 parts by weight of hawthorn and 60 parts of red dates into a 2.3 kW pitting machine, setting the pitting temperature at 22° C. and the pitting time at 21 min, and performing pitting to obtain pitted hawthorn and pitted red dates;

[0106] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.6 kW grinder at a grinding temperature of 24° C. for 38 min to obtain a hawthorn and red date mixture;

[0107] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 6 kW, the beating temperature is, the beating time is 26°C, and the beating time is 26 min, and beat to obtain a taste improver.

[0108] The nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, jujube seeds, and ultrapure water.

[0109] The preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0110] L1. Weigh 63 parts by weight of mulberry leaves, 45 parts of cassia seeds, 23 parts of spinach seeds, and 530 parts of ultrapure water, and place them in a 19 kW vacuum cooker with a vacuum degree of -0.06 MPa, a cooking temperature of 128° C., and a cooking time of 16 minutes to obtain a nerve-soothing composition;

[0111] L2, placing the nerve-soothing composition prepared in L1 into a filter with a power of 2.3 kW and a filtration accuracy of 7 mm, filtering and removing the filter residue to obtain a high-temperature nerve-soothing composite solution;

[0112] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant temperature stainless steel barrel at 19°C for 1.3 h to obtain the nerve-soothing compound liquid.

[0113] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0114] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them in a 3.3 kW grinder at a temperature of 21° C. for 1.4 h to obtain a mixed herbal powder;

[0115] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 50-mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0116] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a steaming machine with a power of 3.4 kW, a steam pressure of 95 kPa, a steaming temperature of 112° C., and a steaming time of 42 min, and steam the mixture to obtain steamed mixed Chinese herbal medicine powder;

[0117] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, place the mixture in a 3.2 kW blender, stir at a temperature of 26° C., a speed of 115 r / min, and a stirring time of 32 min, and mix to obtain a drug mixture for treating myocardial injury;

[0118] Step 5: Place the drug mixture for treating myocardial injury prepared in step 4 into a tablet press with a power of 2.3 kW, a tableting pressure of 10 kN, a tableting diameter of 8 mm, a tableting temperature of 33° C., and a tableting time of 1.4 h to obtain tablets for treating myocardial injury;

[0119] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 78°C, rotate at 65 r / min, stir for 12 minutes, then cool to 31°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 25 seconds, and then remove to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0120] Step 7: Place the moistened pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a 2.5kW dryer for drying at a temperature of 29°C for 16 minutes to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0121] Example 5: This example provides a pharmaceutical composition for repairing tumors and treating myocardial damage and a preparation method thereof. The pharmaceutical composition for repairing tumors and treating myocardial damage comprises the following components in parts by weight:

[0122] 260 parts of Astragalus, 170 parts of Chuanxiong, 140 parts of Rehmannia root, 110 parts of Dragon bone, 105 parts of Poria, 68 parts of Psoralea corylifolia, 53 parts of Black Fungus, 72 parts of taste improver, 180 parts of nerve soothing compound liquid, 115 parts of rice starch, 17 parts of sodium bicarbonate, and 145 parts of ultrapure water.

[0123] The taste improver specifically includes: hawthorn and red dates.

[0124] The preparation method of the mouthfeel improver specifically comprises the following steps:

[0125] S1. Weighing 155 parts by weight of hawthorn and 75 parts of red dates into a 2.8 kW pitting machine at a pitting temperature of 24° C. for 23 min to obtain pitted hawthorn and pitted red dates;

[0126] S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.7 kW grinder at a grinding temperature of 25° C. for 43 min to obtain a hawthorn and red date mixture;

[0127] S3. Put the hawthorn and red date mixture prepared in S2 into a beater with a power of 7.5 kW, the beating temperature is, the beating time is 29°C, and the beating time is 28 min, and beat to obtain a taste improver.

[0128] The nerve-soothing compound liquid specifically includes: mulberry leaves, cassia seeds, jujube seeds, and ultrapure water.

[0129] The preparation method of the nerve-soothing compound liquid specifically comprises the following steps:

[0130] L1. Weigh 68 parts by weight of mulberry leaves, 55 parts of cassia seeds, 28 parts of spinach seeds, and 580 parts of ultrapure water, and place them in a 21 kW vacuum cooker with a vacuum degree of -0.02 MPa, a cooking temperature of 133° C., and a cooking time of 19 minutes to obtain a nerve-soothing composition;

[0131] L2, placing the nerve-soothing composition prepared in L1 into a filter with a power of 2.8 kW and a filtration accuracy of 9 mm, filtering and removing the filter residue to obtain a high-temperature nerve-soothing composite solution;

[0132] L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant-temperature stainless steel barrel at 21°C for 1.4 h to obtain the nerve-soothing compound liquid.

[0133] The present invention also provides a method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage, which specifically comprises the following steps:

[0134] Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them in a 3.8 kW grinder at a temperature of 23° C. for 1.5 h to obtain a mixed herbal powder;

[0135] Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 200-mesh filter to obtain a fine mixed Chinese herbal medicine powder;

[0136] Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a steaming machine with a power of 3.5 kW, a steam pressure of 97 kPa, a steaming temperature of 114° C., and a steaming time of 43 min, and steam the mixture to obtain steamed mixed Chinese herbal medicine powder;

[0137] Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, place the mixture in a 3.8 kW blender, stir at a temperature of 27° C., a speed of 120 r / min, and a stirring time of 38 min, and mix to obtain a drug mixture for treating myocardial injury;

[0138] Step 5: Place the drug mixture for treating myocardial injury prepared in step 4 into a tablet press with a power of 2.4 kW, a tableting pressure of 11 kN, a tableting diameter of 9 mm, a tableting temperature of 34° C., and a tableting time of 1.5 h to obtain tablets for treating myocardial injury;

[0139] Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 83°C, rotate at 75 r / min, stir for 13 minutes, then cool to 33°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 28 seconds, and then remove from the mixture to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury;

[0140] Step 7: Place the moistened pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a 3.1kW dryer for drying at a temperature of 29°C for 19 minutes to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

[0141] Experimental Example 1: Left ventricular ejection fraction measurement in myocardial infarction model mice.

[0142] The test steps for determining the left ventricular function repair of myocardial infarction mice using the pharmaceutical composition for repairing tumors and treating myocardial damage prepared in Examples 1-5 of the present invention are as follows:

[0143] (1) Sixty male Kunming mice weighing 25 g were selected and divided into six groups of 10 mice each. After 2 days of feeding in an environment with a temperature of 24°C, a humidity of 50%, and a light intensity of 12 h per day, the mice were fasted for 12 h and placed in the induction box of the anesthesia machine. The oxygen flow rate was adjusted to 0.25 MPa, 1 L / min, and the concentration of the anesthetic isoflurane was adjusted to 5%. The induction anesthesia of the mice was completed in about 1 min. After that, the isoflurane concentration was adjusted to 2%. The mice were connected to the mask and continued to inhale.

[0144] (2) The mouse was fixed in a supine position. The hair of the mouse was removed and disinfected in the surgical area on the left chest. A 1.5 cm long longitudinal incision was made in the skin 2 mm from the left edge of the sternum. A vertical mattress suture was made at the incision to reserve sutures. The chest wall muscles were bluntly separated layer by layer. The chest cavity was quickly entered from the 3rd or 4th intercostal space. The intercostal space was opened with hemostatic forceps. In coordination with the beating of the heart, the left hand was gently squeezed to make the heart pop out of the hole. An 8-0 suture needle with thread was used to pass through the anterior descending coronary artery 2 mm below the lower edge of the left atrial appendage and 0.5 mm next to the pulmonary artery cone to ligate it. The tightness was appropriate to control the needle insertion depth and the needle width was 2 mm. When the outer surface of the anterior wall of the left ventricle turned pale, it was proved that the ischemia was successful.

[0145] (3) The thoracotomy time should not exceed 30 seconds, and the ligation operation should be completed within 10 seconds. After the ligation is completed, the heart should be gently returned to the chest cavity, the air should be expelled from the chest cavity, and the sutures reserved at the ligation incision should be tightened to complete the operation. During the operation, the isoflurane concentration should be gradually adjusted to zero. After removing the mask, the mouse should be placed on a constant temperature pad for 5 minutes for resuscitation to obtain a myocardial infarction model mouse.

[0146] (4) One day and eight days after the myocardial infarction operation, mice were gavaged with 0.15 g of the pharmaceutical composition for repairing tumors and treating myocardial injury prepared in Examples 1-5, and 0.15 g of 0.9% saline solution were taken daily as the CK control group.

[0147] (5) The Vevo-2100 small animal ultrasound imaging device was used to examine the mice in each group before the myocardial infarction operation and 1 day, 3 days, 7 days, and 14 days after the myocardial infarction operation. The mice in each group were anesthetized by inhaling 1% isoflurane with a gas anesthesia machine. The chest hair was removed and the skin was prepared. The mice were placed in a supine position on the examination platform, and coupling agent was applied to the chest area. The frequency of the high-frequency ultrasound probe was adjusted to 10 MHz. The standard left ventricular parasternal long axis section was selected to accurately measure the left ventricular ejection fraction of the mice.

[0148] Experimental Example 2: Test for measuring myocardial cell indicators in mice after tumor treatment.

[0149] The test steps for measuring myocardial cell indicators in mice after tumor treatment using the pharmaceutical composition for repairing tumors and treating myocardial damage prepared in Examples 1-5 of the present invention are as follows:

[0150] (1) Sixty male Kunming mice weighing 25 g were selected and the liver cancer H 22 The cells were inoculated into the peritoneal cavity of mice, with 0.1 mL per mouse and 2×10 6 The mice were divided into 6 groups with 10 cells per group and fed in an environment of 24°C, 50% humidity, and 12 hours of light per day for 8 days. Then, 100 mL of atezolizumab injection was injected through the tail vein once a day for 5 consecutive days to obtain tumor-treated mice.

[0151] (2) After tumor treatment, mice in experimental groups 1-5 were gavaged daily with 0.15 g of the pharmaceutical composition for repairing tumors and treating myocardial damage prepared in Examples 1-5, and 0.15 g of 0.9% saline as a CK control group. After 5 consecutive days of gavage, the mice were killed by cervical dislocation, and 0.5 mL of saline was immediately injected into the abdominal cavity. The abdominal cavity was rubbed for 2 minutes, the abdominal skin was cut open, 0.2 g of heart tissue was removed, and injected into a culture dish containing sterile 1×PBS to wash away the blood on the tissue surface;

[0152] (3) Use scissors to cut the cleaned heart tissue into 1 mm pieces 3The fragments of different sizes were analyzed using mouse cardiac calpain enzyme-linked immunosorbent assay kit (Huamei Biotechnology, catalog number: CSB-E08421m), creatine kinase MB isoenzyme assay kit (Beden Medical, catalog number: V251577), mouse myoglobin enzyme-linked immunosorbent assay kit (Huamei Biotechnology, catalog number: CSB-E08050m), lactate dehydrogenase assay kit (Elabscience, catalog number: E-BC-K046-M), and aspartate aminotransferase assay kit (Fusheng, catalog number: A097457) to measure the myocardial troponin content, creatine kinase MB isoenzyme activity, myoglobin content, lactate dehydrogenase activity, and aspartate aminotransferase activity of mouse myocardial cells after tumor treatment.

[0153] Result analysis:

[0154] Figure 1 This is a graph showing the results of measuring the left ventricular ejection fraction of mice with myocardial infarction as described in Experimental Example 1 of the present invention. As shown in the figure, after the pharmaceutical composition for repairing tumors and treating myocardial damage described in Examples 1-5 was taken by mice with myocardial infarction model, the left ventricular ejection fraction of the mice was maintained at 68.8% 14 days after the myocardial infarction construction operation, while the left ventricular ejection fraction of mice in the CK control group was 19.4% 14 days after the myocardial infarction construction operation, indicating that the pharmaceutical composition for repairing tumors and treating myocardial damage described in the present invention can improve the contractile function of the left ventricle after myocardial infarction and maintain the left ventricular pumping function.

[0155] Figure 2 This is a graph showing the results of measuring the troponin content in myocardial cells of mice after tumor treatment as described in Experimental Example 2 of the present invention. As shown in the figure, after the pharmaceutical composition for repairing tumor-treated myocardial damage described in Examples 1-5 was taken by mice after tumor treatment, the troponin content in the myocardial cells of the mice was 0.079 ng / mL, 0.074 ng / mL, 0.063 ng / mL, 0.077 ng / mL, and 0.067 ng / mL. The troponin content in the myocardial cells of mice in the CK control group was 0.237 ng / mL. Figure 3 This is a graph showing the results of measuring myoglobin content in myocardial cells of mice after tumor treatment as described in Experimental Example 2 of the present invention. After the pharmaceutical composition for repairing tumor-treated myocardial damage described in Examples 1-5 was administered to mice after tumor treatment, the myoglobin content in the myocardial cells of the mice was 72.9 ng / mL, 70.5 ng / mL, 68.7 ng / mL, 70.7 ng / mL, and 69.3 ng / mL, respectively. The myoglobin content in the myocardial cells of mice in the CK control group was 113.7 ng / mL. Figure 4This is a graph showing the results of enzyme activity determination of mouse myocardial cells after tumor treatment as described in Experimental Example 2 of the present invention. As shown in the figure, after the pharmaceutical composition for repairing tumor-treated myocardial damage described in Examples 1-5 was taken by mice after tumor treatment, the creatine kinase MB isoenzyme activity in the mouse myocardial cells was 27 U / L, the lactate dehydrogenase activity was 236 U / L, and the aspartate aminotransferase activity was 32 U / L. In contrast, the creatine kinase MB isoenzyme activity, lactate dehydrogenase activity, and aspartate aminotransferase activity in the myocardial cells of mice in the CK control group were 59 U / L, 265 U / L, and 48 U / L, respectively. This indicates that the pharmaceutical composition for repairing tumor-treated myocardial damage described in the present invention can repair myocardial cell damage caused by myocardial infarction, myocardial ischemia, myocarditis, and arrhythmia after tumor treatment, and has a fast efficacy and significant effect.

[0156] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

[0157] The present invention and its embodiments are described above. Such description is not restrictive. The drawings show only one embodiment of the present invention, and actual applications are not limited thereto. In short, if a person skilled in the art is inspired by the above, and does not deviate from the purpose of the present invention, any method and embodiment similar to the technical solution without creative design shall fall within the scope of protection of the present invention.

Claims

1. A pharmaceutical composition for repairing tumors and treating myocardial damage, characterized in that: The pharmaceutical composition for repairing tumors and treating myocardial damage is composed of the following components in parts by weight: 150-280 parts of Astragalus, 130-180 parts of Chuanxiong, 100-145 parts of Rehmannia root, 80-120 parts of Dragon bone, 75-110 parts of Poria, 60-70 parts of Psoralea corylifolia, 40-55 parts of Black Fungus, 60-75 parts of taste improver, 160-190 parts of nerve soothing compound solution, 100-120 parts of rice starch, 15-18 parts of sodium bicarbonate, and 130-150 parts of ultrapure water; The taste improver is composed of hawthorn and red dates; The preparation method of the mouthfeel improver specifically comprises the following steps: S1. Weigh 140-160 parts by weight of hawthorn and 50-80 parts of red dates and put them into a pitting machine with a power of 2-3 kW. The pitting temperature is 20-25° C. and the pitting time is 20-25 min. The pitting is performed to obtain pitted hawthorn and pitted red dates; S2, placing the pitted hawthorn and pitted red dates prepared in S1 into a 1.5-1.8 kW grinder at a grinding temperature of 23-26° C. for 35-45 min to obtain a hawthorn and red date mixture; S3, the hawthorn and red date mixture prepared in S2 was placed in a beater with a power of 5-8 kW, the beating temperature was , the beating time was 25-30° C., and the beating time was 25-30 min, and the taste improver was obtained; The nerve-soothing compound solution is composed of mulberry leaves, cassia seeds, spinach seeds, and ultrapure water; The preparation method of the nerve-soothing compound liquid specifically comprises the following steps: L1. Weigh 60-70 parts by weight of mulberry leaves, 40-60 parts of cassia seeds, 20-30 parts of spinach seeds, and 500-600 parts of ultrapure water, and place them in a vacuum cooker with a power of 18-22 kW, and cook at a vacuum degree of -0.08-0 MPa at a temperature of 120-135° C. for 15-20 minutes to obtain a nerve-soothing composition; L2. Place the nerve-soothing composition prepared in L1 into a filter with a power of 2-3 kW and a filtration accuracy of 5-10 mm, filter and remove the residue to obtain a high-temperature nerve-soothing compound solution; L3. Place the high-temperature nerve-soothing compound liquid prepared in L2 into a constant-temperature stainless steel barrel at a temperature of 18-22°C for 1.2-1.5 hours to obtain the nerve-soothing compound liquid.

2. A method for preparing the pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 1, characterized in that: The specific steps include: Step 1: Weigh appropriate weight portions of Astragalus, Chuanxiong, Rehmannia root, Dragon bone, Poria, Psoralea corylifolia, and Auricularia auricula, and grind them into powder in a powder grinder to obtain mixed herbal powder; Step 2: Filter the mixed Chinese herbal medicine powder prepared in step 1 through a 50-200 mesh filter to obtain a fine mixed Chinese herbal medicine powder; Step 3: Place the fine mixed Chinese herbal medicine powder prepared in step 1 into a medicine steaming machine and steam it to obtain steamed mixed Chinese herbal medicine powder; Step 4: Weigh appropriate weight portions of a mouthfeel improver and a nerve-soothing compound solution, add the steamed mixed Chinese herbal medicine powder prepared in step 3, put them into a blender, and stir to obtain a drug mixture for treating myocardial injury; Step 5: placing the drug mixture for treating myocardial injury prepared in step 4 into a tablet press, and compressing the tablets to obtain lozenges for treating myocardial injury; Step 6: Weigh appropriate weight portions of rice starch, sodium bicarbonate, and ultrapure water, place them in a constant temperature stirring pot, heat to 75-85°C, rotate at 60-80 r / min, stir for 12-13 minutes, then cool to 30-33°C, add the myocardial injury treatment lozenge prepared in step 5, soak for 20-30 seconds, and then remove to obtain a pharmaceutical composition for moisturizing tumor repair and treating myocardial injury; Step 7: Place the wet pharmaceutical composition for repairing tumors and treating myocardial damage prepared in step 6 into a dryer for drying to obtain the pharmaceutical composition for repairing tumors and treating myocardial damage.

3. The method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 2, characterized in that: In step 1, the power of the powder pulverizer is 3-4 kW, the powder pulverizing temperature is 20-25° C., and the powder pulverizing time is 1.3-1.6 h.

4. The method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 3, characterized in that: In step three, the power of the medicine steaming machine is 3.3-3.6 kW, the steam pressure is 93-98 kPa, the medicine steaming temperature is 110-115° C., and the medicine steaming time is 40-45 min.

5. The method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 4, characterized in that: In step 4, the stirrer power is 2.5-4 kW, the stirring temperature is 25-28° C., the stirring speed is 110-130 r / min, and the stirring time is 30-40 min.

6. The method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 5, characterized in that: In step 5, the tablet press has a power of 2.2-2.5 kW, a tableting pressure of 10-12 kN, a tableting diameter of 7-10 mm, a tableting temperature of 30-35° C., and a tableting time of 1.2-1.6 h.

7. The method for preparing a pharmaceutical composition for repairing tumors and treating myocardial damage according to claim 6, characterized in that: In step seven, the dryer power is 1.6-3.2 kW, the drying temperature is 28-30° C., and the drying time is 15-20 min.

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