Multifunction pipettor and automated detection machine

Abstract

A multifunctional pipettor and an automated detection machine are disclosed. The multifunctional pipettor includes a pipettor module, a heating module, and a magnetic module. The pipettor module includes a plurality of pipette tips. The heating module has a first engagement portion. The heating module is coupled with the pipette tips via the first engagement portion to removably connect the pipettor module. The magnetic module has a second engagement portion. The magnetic module is coupled with the pipette tips via the second engagement portion to removably connect the pipettor module.

Description

Technical Field

[0001] This invention relates to pipetting equipment, and more particularly to a multifunctional pipette and an automated testing machine. Background Technology

[0002] In laboratory experiments, pipettes are widely used to aspirate minute volumes of liquid and drop them into laboratory dishes. Therefore, pipettes are an indispensable instrument for laboratory personnel in various experiments. Furthermore, in addition to the actions of aspirating and dispensing liquid from the sample using a pipette, the analysis process may also involve stirring, heating, mixing, and magnetic attraction, thus often requiring multiple tools or instruments to assist in completing the necessary actions throughout the analytical process.

[0003] However, as the number of samples to be tested increases, manual laboratory analysis becomes challenging. Therefore, developing automated testing equipment to meet the needs of various testing experiments is a problem that all parties are striving to solve. Summary of the Invention

[0004] In one embodiment, a multifunctional pipette includes a pipette module, a heating module, and a magnetic module. The pipette module has multiple pipette connectors. The heating module has a first engagement portion. The heating module is removably connected to the pipette module via the first engagement portion and coupled to the pipette connectors.

[0005] The magnetic module has a second engagement portion, through which the magnetic module is removably connected to the pipette connector for coupling.

[0006] In one embodiment, an automated testing machine includes a testing platform, a multifunctional pipette, and a moving mechanism. The testing platform has multiple working areas. The multifunctional pipette includes a pipette module, a heating module, and a magnetic module. The moving mechanism is connected to the multifunctional pipette and is used to move the multifunctional pipette between the working areas.

[0007] The pipette module has multiple pipette connectors. The heating assembly has a first engagement. The heating module is removably connected to the pipette connectors via the first engagement.

[0008] The magnetic module has a second engagement portion, through which the magnetic module is removably connected to the pipette connector for coupling.

[0009] In summary, according to any embodiment, the multifunctional pipette, in addition to its aspiration and dispensing functions, can be removably assembled with heating or magnetic modules to heat, stir, or apply magnetic force to the sample. Therefore, it provides multiple processing functions with a single tool, simplifying the tools and / or instruments required for laboratory analysis, and even simplifying operating procedures and space requirements. According to some embodiments, the multifunctional pipette can be used in automated testing machines, and its automatic assembly and replacement between various functions can be achieved through a moving mechanism, providing convenient and rapid automated operation for laboratory analysis while saving operating space. Attached Figure Description

[0010] Figure 1 A schematic diagram showing the appearance of a multifunctional pipette in its first application state;

[0011] Figure 2 for Figure 1 Internal diagram of the pipette module in the image;

[0012] Figure 3 for Figure 1 Functional block diagram of the heating module in the diagram;

[0013] Figure 4 for Figure 1 An enlarged schematic diagram of the heating module in the image;

[0014] Figure 5 A schematic diagram showing the appearance of a multifunctional pipette in its second application state;

[0015] Figure 6 A schematic diagram showing the appearance of a multifunctional pipette in its second application state;

[0016] Figure 7 A schematic diagram showing the appearance of a multifunctional pipette in its second application state;

[0017] Figure 8 for Figure 7 Functional block diagram of the magnetic module in the image;

[0018] Figure 9 for Figure 7 An enlarged schematic diagram of the magnetic module in the image;

[0019] Figure 10 for Figures 1-2 and Figures 5-7 Internal diagram of the pipette module in the image;

[0020] Figure 11 for Figure 10 A schematic diagram of the back of the pipette module;

[0021] Figure 12 for Figure 10 An exploded view of the pipette module in the diagram;

[0022] Figure 13 This is a schematic diagram of an automated inspection machine according to one embodiment;

[0023] Figure 14 for Figure 13 An exploded view of the storage base;

[0024] Figure 15 A schematic diagram of a multi-functional pipette in manual mode;

[0025] Figure 16 This is a schematic diagram of the appearance of a multifunctional pipette in its third application state.

[0026] Symbol Explanation

[0027] 1: Pipette Module

[0028] 11: Pipette housing

[0029] 12: Piston assembly

[0030] 121: Opening

[0031] 122: Air passage

[0032] 123: Piston rod

[0033] 13: Straw connector

[0034] 14: Power supply end

[0035] 15: Linear guide rail

[0036] 16: Linkage components

[0037] 17: Limiting component

[0038] 171: Upper limit component

[0039] 172: Lower limit component

[0040] 18: Motor

[0041] 19: Exit Structure

[0042] 191: Perforation

[0043] 111: Cylinder

[0044] 112: Linked film

[0045] 113: Screw

[0046] 114: Elastic component

[0047] 115: Top-mounted component

[0048] 2: Heating module

[0049] 21: Heat-resistant shell

[0050] 22: Heating rod

[0051] 23: First connection end

[0052] 211: First recessed portion

[0053] 212: Heat-resistant shell fixing base

[0054] 213: Heat-resistant shell extension arm

[0055] 2121: First joint

[0056] 2122: Second surface of heat-resistant shell

[0057] 2123: Third surface of heat-resistant shell

[0058] 2124: Fourth surface of heat-resistant shell

[0059] 3: Magnetic Module

[0060] 31: Connecting sleeve

[0061] 311: Second joint

[0062] 3111: Recessed part of the sleeve

[0063] 32: Permanent magnet rod

[0064] 33: Magnetic module fixing base

[0065] 331: Second joint

[0066] 332: Second surface of magnetic module

[0067] 3311: Second recess of magnetic module

[0068] 34: Permanent Magnet Rod

[0069] 35: Connecting housing

[0070] 36: Electromagnetic rod

[0071] 37: Second connection end

[0072] 351: Second recess of magnetic module

[0073] 352: Connecting housing fixing base

[0074] 353: Connecting housing extension arm

[0075] 3521: Second joint

[0076] 3522: Connecting the second surface of the housing

[0077] 3523: Connecting the third surface of the housing

[0078] 3524: Connecting the fourth surface of the housing

[0079] 4: Automated testing machines

[0080] 41: Testing Platform

[0081] 42: Multifunctional pipette

[0082] 43: Mobile mechanism

[0083] 44: Storage Base

[0084] 411: Work Area

[0085] 5: Micropipette tip

[0086] 6: Grip section

[0087] X: X-axis direction

[0088] Y: Y-axis direction

[0089] Z: Z-axis direction Detailed Implementation

[0090] In some embodiments, the multifunctional pipette 42 includes: a pipette module 1, a heating module 2, and a magnetic module 3. When the heating module 2 is not connected to the pipette module 1, the magnetic module 3 is connected to the pipette module 1 as needed and removably; wherein, when the magnetic module 3 is not connected to the pipette module 1, the heating module 2 is connected to the pipette module 1 as needed and removably.

[0091] This multi-functional pipette 42 has three application states (hereinafter referred to as the first application state, the second application state, and the third application state, respectively). In the first application state, the multi-functional pipette 42 has a heating function. In the second application state, the multi-functional pipette 42 has a magnetic force and stirring function. In the third application state, the multi-functional pipette 42 has a pipetting function.

[0092] This describes the first application state. A multifunctional pipette 42 includes: a pipette module 1 and a heating module 2 (such as...). Figure 1 and Figure 2 As shown in the figure, the portion of pipette module 1 where heating module 2 is installed is presented in exploded view.

[0093] The pipette module 1 includes: multiple pipette connectors 13, multiple piston assemblies 12, and a pipette housing 11.

[0094] Each straw connector 13 corresponds to a piston assembly 12, and each straw connector 13 is located at one end of its corresponding piston assembly 12. Furthermore, the number of piston assemblies 12 is the same as the number of straw connectors 13. It should be clear that... Figure 1 Although it is presented as having 8 piston assemblies 12 and 8 straw connectors 13, the number of piston assemblies 12 and straw connectors 13 can be adapted to other numbers according to actual needs, such as 2, 3, 4, 5, 6, 7, or more than 8.

[0095] See Figure 1 and Figure 2 The piston assembly 12 includes multiple air channels 122 and multiple piston rods 123. The piston rods 123 are axially reciprocatingly inserted into the air channels 122 from a first end. The second end of the air channel 122 has an opening 121, which is connected to a corresponding straw connector 13. In other words, each piston assembly 12 is coupled to a corresponding straw connector 13. Thus, when the piston rods 123 reciprocate within the air channels 122, i.e., when the piston is actuated, the piston assembly 12 can draw liquid into or expel liquid from the micro-piston tip 5.

[0096] In some embodiments, the air passages 122 of all piston assemblies 12 can be integrated into a single cylinder 111 (e.g., Figure 2 As shown, the cylinder 111 is located inside the pipette housing 11. Air channels 122 are parallel to each other and spaced apart inside the cylinder 111, with each air channel 122 extending from top to bottom through the cylinder 111. The first end of each air channel 122 forms an opening on the upper surface of the cylinder 111, while the second end of each air channel 122 forms another opening 121 on the lower surface of the cylinder 111. This opening 121 is located near the side of the pipette housing 11. Each pipette connector 13 is fixed to the pipette housing 11.

[0097] Herein, the heating module 2 includes: a first joint 2121, a plurality of power supply terminals 14, a plurality of heating rods 22, a plurality of first connection terminals 23, and a heat-resistant housing 21.

[0098] In some embodiments, the heating module 2 is removably connected to the pipette module 1 via a first engagement 2121 and coupled to at least one plurality of pipette connectors 13. Specifically, the plurality of pipette connectors 13 define a plurality of first recesses 211 relative to the plurality of pipette connectors 13. The first engagement 2121 has a plurality of first recesses 211. Each plurality of first recesses 211 corresponds to a corresponding plurality of pipette connectors 13. Specifically, the distribution positions of the first recesses 211 are the same as the relative distribution positions of the corresponding pipette connectors 13 on the pipette housing 11, so that when the pipette module 1 and the heating module 2 are close to each other, the plurality of pipette connectors 13 can be respectively inserted into their respective first recesses 211. The first recesses 211 are used to accommodate the pipette connectors 13. The configuration of the first recesses 211 has a limiting structure design for the pipette connectors 13, for example, the inner surface of the first recesses 211 is concave. This is to avoid the offset of the heating module 2 assembled on the pipette module 1, that is, when the heating module 2 is assembled on the pipette module 1, the central axis of each first recess 211 coincides with the central axis of any pipette connector 13.

[0099] In some embodiments, the number of first recesses 211 may be the same as or less than the number of straw connectors 13. When the straw connectors 13 and the first recesses 211 are coupled one-to-one, the number of straw connectors 13 and the number of first recesses 211 are preferably two or more each.

[0100] These power supply terminals 14 are embedded in the pipette housing 11. These power supply terminals 14 and these pipette connectors 13 face the same direction, as shown below. Figure 1 and Figure 2 Both shown face the heating module 2. In some embodiments, these power supply terminals 14 include a positive contact and a negative contact.

[0101] The first joint 2121 is located on one side of the heat-resistant housing 21. The first joint 2121 and the plurality of heating rods 22 are disposed on different sides of the heat-resistant housing 21, preferably facing each other. Furthermore, a plurality of first connecting ends 23 are embedded in the heat-resistant housing 21. These first connecting ends 23 correspond to a plurality of power supply terminals 14 and are electrically connected to the plurality of heating rods 22. The first connecting ends 23 and the first joint 2121 face the same direction.

[0102] Here, the heating rods 22 are respectively aligned with the first recesses 211. Specifically, the central axis of each heating rod 22 passes through the center point of the corresponding first recess 211. In some embodiments, the number of heating rods 22 may be the same as or less than the number of straw connectors 13.

[0103] It should be clear that, Figure 1 , Figure 2 and Figure 4 Although it is presented with eight first recesses 211 and eight heating rods 22, the number of first recesses 211 and the number of heating rods 22 can be adapted to other numbers according to actual needs, such as 1, 2, 3, 4, 5, 6, 7 or more.

[0104] The heat-resistant housing 21 also includes a fixed base 212 and at least two extension arms 213. The fixed base 212 includes a first joint 2121, a second surface 2122, a third surface 2123, and a fourth surface 2124. Specifically, the first joint 2121 and the second surface 2122 are arranged opposite to each other, and the third surface 2123 and the fourth surface 2124 are respectively connected between the first joint 2121 and the second surface 2122. A plurality of heating rods 22 pass through the second surface 2122. In some embodiments, there are two extension arms 213, one end of which is connected to the third surface 2123, and the other end of which is connected to the fourth surface 2124. The other end of each extension arm 213 faces the same direction as the first joint 2121, such as... Figure 1 and Figure 2 Both shown face the pipette module 1. Each first connection end 23 is located on the end face of the other end of the extension arm 213. In some embodiments, the three-dimensional shape of the extension arm 213 is substantially L-shaped.

[0105] In some embodiments, the heat-resistant housing 21 has a withstand temperature (i.e., a temperature at which the material of the heat-resistant housing 21 will not change) that is greater than the heating temperature of the heating rod 22.

[0106] Therefore, when the heating module 2 is removably assembled onto the pipette module 1 via the first recess 211 and the pipette connector 13, the plurality of first connection ends 23 are electrically connected to the plurality of power supply ends 14 (e.g., ...). Figure 3 (As shown).

[0107] Each pipette connector 13 is inserted into and engaged with the corresponding first recess 211, allowing the heating module 2 to be assembled onto the pipette module 1. Simultaneously, the electrical contacts of each power supply terminal 14 are electrically connected to the electrical contacts of the corresponding first connection terminal 23. Therefore, in the first application state, the pipette module 1 can drive the heating rod 22 on the heating module 2 via the electrical connection between the power supply terminal 14 and the first connection terminal 23, causing the heating rod 22 to heat up.

[0108] When pipetting is required, the pipette connector 13 of the pipette module 1 is fitted with the micropipette tip 5, allowing liquid to be drawn into or expelled from the micropipette tip 5 via the piston assembly 12. When heating is required, the micropipette tip 5 fitted on the pipette connector 13 can be detached and replaced with a fitting that connects to the first recess 211 to assemble the heating module 2 onto the pipette module 1. Similarly, when pipetting is required again, the heating module 2 fitted on the pipette connector 13 can be detached and replaced with a fitting that connects to a micropipette tip 5 of the required size.

[0109] This section describes the second application state. The pipette module 1, with the magnetic module 3 mounted on it, is shown in an exploded view (e.g., ...). Figures 5 to 8 Please see ). Figure 5 The magnetic module 3 includes a second engagement 311, through which the magnetic module 3 is removably connected to the pipette module 1 by coupling with eight pipette connectors 13. The structure and function of the pipette module 1 are generally the same as in any of the aforementioned embodiments, and will not be described again. The magnetic module 3 includes eight connecting sleeves 31 and eight permanent magnet rods 32. These connecting sleeves 31 include the second engagement 311. This second engagement 311 is composed of eight sleeve recesses 3111, each located at one end of one of the connecting sleeves 31. The eight pipette connectors 13 define eight sleeve recesses 3111 relative to each pipette connector 13. Each of the eight sleeve recesses 3111 matches a corresponding pipette connector 13. The central axis of each connecting sleeve 31 coincides with the central axis of any pipette connector 13, such that when the pipette module 1 and the magnetic module 3 are brought close together, the pipette connector 13 can be inserted one-to-one into the corresponding sleeve recess 3111. The sleeve recess 3111 is used to accommodate the pipette connector 13. In addition, eight permanent magnet rods 32 are respectively provided on the other end of the eight corresponding connecting sleeves 31.

[0110] In some embodiments, the number of connecting sleeves 31 may be the same as or less than the number of straw connectors 13.

[0111] In some embodiments, please refer to Figure 6The magnetic module 3 includes a fixed base 33 and eight permanent magnet rods 34. The fixed base 33 includes a second engagement portion 331 and a second surface 332 opposite to each other. The eight straw connectors 13 define eight second recesses 3311 relative to the eight straw connectors 13. The second engagement portion 331 has eight second recesses 3311, which match and fit onto the corresponding straw connectors 13. The eight permanent magnet rods 34 pass through the second surface 332, and the eight permanent magnet rods 34 are respectively aligned with the eight second recesses 3311. The central axis of each of the eight straw connectors 13 coincides with the central axis of any of the second recesses 3311. Specifically, the second recesses 3311 on the fixing base 33 are positioned in the same way as the corresponding pipette connectors 13 on the pipette housing 11, so that when the pipette module 1 and the magnetic module 3 approach each other, the pipette connectors 13 can be inserted one-to-one into the corresponding second recesses 3311. The second recesses 3311 are used to accommodate the pipette connectors 13. In some embodiments, the number of second recesses 3311 may be the same as or less than the number of pipette connectors 13.

[0112] In some embodiments, please refer to Figure 7 and Figure 9 The magnetic module 3 includes: eight second recesses 351 located at the second joint 3521, two power supply terminals 14 disposed on the pipette housing 11, eight electromagnets 36 disposed opposite the second joint 3521, and two second connection terminals 37. Eight pipette connectors 13 define eight second recesses 351 relative to the eight pipette connectors 13. These second connection terminals 37 correspond to the power supply terminals 14 respectively and are electrically connected to the electromagnets 36, wherein the electrical contacts of the second connection terminals 37 are abutted against the corresponding electrical contacts of the power supply terminals 14 for electrical connection. Thus, when the magnetic module 3 is removably assembled onto the pipette module 1 by fitting the eight pipette connectors 13 through the eight second recesses 351, the two second connection terminals 37 are electrically connected to the two power supply terminals 14 respectively. These second connection terminals 37 face the same direction as the second joint 3521. Furthermore, the second recesses 351 on the connecting housing 35 are positioned in the same way as the corresponding pipette connectors 13 on the pipette housing 11, so that when the pipette module 1 and the magnetic module 3 are close to each other, the pipette connectors 13 can be inserted one-to-one into the corresponding second recesses 351. The second recesses 351 are used to accommodate the pipette connectors 13.

[0113] The second recesses 3311 and 351 (and the sleeve recess 3111) are configured with a limiting structure design for the pipette connector 13. For example, the inner surfaces of the second recesses 3311 and 351 (and the sleeve recess 3111) are concave. This is to prevent the magnetic module 3 from shifting when assembled on the pipette module 1, that is, when the magnetic module 3 is assembled on the pipette module 1, the central axis of each of the second recesses 3311 and 351 (and the sleeve recess 3111) coincides with the central axis of any pipette connector 13.

[0114] In some embodiments, the number of second recesses 3311, 351 (and sleeve recess 3111) and / or the number of electromagnet rods 36 may be the same as or less than the number of straw connectors 13. Although the figures show eight second recesses 3311, 351 (and sleeve recess 3111) and eight electromagnet rods 36, the number of second recesses 3311, 351 (and sleeve recess 3111) and the number of electromagnet rods 36 can be adaptively modified to other numbers according to actual needs, such as 1, 2, 3, 4, 5, 6, 7, or more than 8.

[0115] The magnetic module 3 also includes a connecting housing 35. Eight electromagnet rods 36 are disposed on the other side of the connecting housing 35 and are respectively aligned with eight second recesses 351. Two second connecting ends 37 are embedded in the connecting housing 35 and are electrically connected to the eight electromagnet rods 36 respectively.

[0116] In some embodiments, please refer to Figure 9 The connecting housing 35 includes a fixed base 352 and two extension arms 353. The fixed base 352 includes a second joint portion 3521 and a second surface 3522 opposite to each other, and a third surface 3523 and a fourth surface 3524 connecting the second joint portion 3521 and the second surface 3522. Eight second recesses 351 are provided on the second joint portion 3521, and eight electromagnet rods 36 pass through the second surface 3522. One end of one extension arm 353 is connected to the third surface 3523, and one end of the other extension arm 353 is connected to the fourth surface 3524. The other end of each extension arm 353 faces the same direction as the second joint portion 3521. Each second connecting end 37 is located on the end face of the other end of the extension arm 353. In some embodiments, the three-dimensional shape of the extension arm 353 is substantially L-shaped.

[0117] Therefore, in the second application state, the magnetic module 3 is removably connected to the pipette module 1 via the second joints 311, 331, and 3521 and coupled to at least one or more pipette connectors 13, so that the multifunctional pipette 42 has the functions of providing magnetic force and stirring. In one embodiment, by setting a permanent magnet rod 32 on the other end of the corresponding connecting sleeve 31, the pipette module 1 connected to the magnetic module 3 has the functions of providing the required magnetic force and stirring (e.g., Figure 5 (As shown). In another embodiment, a permanent magnet rod 34 is disposed on a fixed base 33 and coupled to a pipette connector 13 via a second joint 331 of the fixed base 33, so that the pipette module 1 connected to the magnetic module 3 has the necessary magnetic force, stirring, and other functions (e.g., as shown). Figure 6 (As shown). In another embodiment, the pipette module 1 can be electrically connected to the second connection terminal 37 via the power supply terminal 14 to drive the electromagnet rod 36 on the magnetic module 3, thereby causing the electromagnet rod 36 to generate a magnetic field (as shown). Figure 7 and Figure 8 (As shown).

[0118] When pipetting is required, the pipette connector 13 of the pipette module 1 is fitted with the micropipette tip 5, allowing liquid to be drawn into or expelled from the micropipette tip 5 via the piston assembly 12. When a magnetic field is required during operation, the micropipette tip 5 fitted on the pipette connector 13 can be detached and replaced with a fitting for the second recess 351 (or a fitting for the second recess 3311, or a fitting for the sleeve recess 3111) to assemble the magnetic module 3 onto the pipette module 1. Similarly, when pipetting is required again, the magnetic module 3 fitted on the pipette connector 13 can be detached and replaced with a fitting for a micropipette tip 5 of the required size.

[0119] In some embodiments, the power supply terminal 14 and the first connection terminal 23 (and the power supply terminal 14 and the second connection terminal 37) can be implemented using mutually matched spring probes (or pogo pins) and guide plates. For example, when the power supply terminal 14 is a spring probe, the corresponding first connection terminal 23 (and the corresponding second connection terminal 37) is a guide plate. Conversely, when the power supply terminal 14 is a guide plate, the corresponding first connection terminal 23 (and the corresponding second connection terminal 37) is a spring probe.

[0120] In some embodiments, please refer to Figures 10 to 12The pipette module 1 also includes a linear guide 15 and a linkage 16. The linkage 16 connects the linear guide 15 to each piston assembly 12. Here, the linkage 16 is used to drive each piston assembly 12 to reciprocate along the linear guide 15. Specifically, the linkage 16 is coupled to the piston rods 123 of all piston assemblies 12. When pipetting is required, the linkage 16 can simultaneously pull out the piston rods 123 of all piston assemblies 12 from the air channel 122, so that the multi-functional pipette 42 can draw liquid into the micropipette tip 5 mounted thereon; or, the linkage 16 can simultaneously push the piston rods 123 of all piston assemblies 12 into the air channel 122, so that the multi-functional pipette 42 can expel liquid from the micropipette tip 5 mounted thereon.

[0121] In some embodiments, please also refer to Figures 10 to 12 The pipette module 1 also includes a limiting component 17, which is connected to the linkage 16. Here, the limiting component 17 limits the movement distance of the linkage 16. Therefore, the multi-functional pipette 42 can precisely control the volume of liquid aspirated or discharged.

[0122] In some embodiments, the limiting component 17 further includes an upper limiting member 171 and a lower limiting member 172, such as Figure 11 As shown. The upper limit member 171 is located at the upper limit of the movement range of the linkage member 16, and the lower limit member 172 is located at the lower limit of the movement range of the linkage member 16.

[0123] In some embodiments, the multi-functional pipette 42 may be of an automated type. Please also refer to... Figure 10 and Figure 11 The pipette module 1 also includes a motor 18, which is located on one side of the pipette housing 11. The motor 18 is used to drive the various piston assemblies 12.

[0124] For example, motor 18 is coupled to linkage 16. When motor 18 pulls linkage 16 away from straw connector 13, linkage 16 can move from upper limit member 171 along linear guide 15 to lower limit member 172, thus pulling the piston rods 123 of all piston assemblies 12 out of air passage 122. When motor 18 pushes linkage 16 towards straw connector 13, linkage 16 can move from lower limit member 172 along linear guide 15 to upper limit member 171, thus pushing the piston rods 123 of all piston assemblies 12 into air passage 122.

[0125] In this way, users can perform pipetting operations by controlling the start of motor 18.

[0126] In some embodiments, please refer to Figure 12The pipette module 1 also includes an exit structure 19, a connecting piece 112, two screws 113, two elastic elements 114, and two abutting elements 115.

[0127] The exit structure 19 is located next to the straw connector 13. The exit structure 19 has multiple perforations 191, and the number of perforations 191 is the same as the number of straw connectors 13. The following description uses eight perforations 191 as an example.

[0128] Eight perforations 191 are formed on the withdrawal structure 19, each perforation 191 surrounding each suction tube connector 13. A connecting piece 112 is disposed above the cylinder 111. One end of the connecting piece 112 is connected to one of the screws 113, and the other end of the connecting piece 112 is connected to the other screw 113. The cylinder 111 is disposed between each screw 113. Two abutting members 115 are positioned at the same horizontal position as each screw 113. A connecting piece 112 is disposed between each abutting member 115 and each screw 113. The two screws 113 are respectively connected to the withdrawal structure 19. Two elastic members 114 are respectively spring-loaded on the screws 113. The connecting piece 112 is disposed at the reciprocating position of the piston assembly 12, and each piston assembly 12 passes through the connecting piece 112, with a portion of each piston assembly 12 located inside the cylinder 111.

[0129] The linkage 16 drives the eight piston assemblies 12 to reciprocate along the linear guide 15. When the linkage 16 moves along the linear guide 15 to the lower limit member 172 and abuts against the linkage plate 112, the linkage plate 112 drives the screw 113, causing the screw 113 to displace in the direction of the withdrawal structure 19. At this time, since the withdrawal structure 19 is coupled to one end of the screw 113, the withdrawal structure 19 will be displaced by the screw 113 and separate from the pipette housing 11, thereby pushing the object (e.g., micropipette tip 5, heating module 2, or magnetic module 3) that is engaged with the pipette connector 13 away from the pipette connector 13. At this time, the elastic member 114 is squeezed due to the displacement of the screw 113, so that the elastic member 114 stores elastic potential energy.

[0130] When the linkage 16 moves away from the lower limit member 172 along the linear guide 15 and no longer abuts against the linkage piece 112, the elastic potential energy stored in the elastic member 114 is converted into the kinetic energy of the object, causing the screw 113 to displace towards the abutment member 115 and abut against the abutment member 115. At this time, the withdrawal structure 19 connected to the screw 113 is displaced towards the pipette housing 11 due to the displacement of the screw 113 and abuts against the pipette housing 11. At this time, the withdrawal structure 19 is located next to each pipette connector 13.

[0131] In some embodiments, the automated multi-functional pipette 42 may be applied to the automated testing machine 4.

[0132] In some embodiments, please refer to Figure 13 The automated testing machine 4 includes a testing platform 41, a multi-functional pipette 42, a moving mechanism 43, and a receiving base 44. The testing platform 41 has multiple working areas 411. The moving mechanism 43 is connected to the multi-functional pipette 42 and is used to move the multi-functional pipette 42 between these working areas 411. In some embodiments, the moving mechanism 43 moves the multi-functional pipette 42 in the X-axis direction, the Y-axis direction, and / or the Z-axis direction. The structure and function of the multi-functional pipette 42 are generally the same as in any of the aforementioned embodiments, and will not be described again. Additionally, the automated testing machine 4 is also equipped with a computer device.

[0133] In some embodiments, the automated testing machine 4 further includes a receiving base 44. The following description uses 10 working areas 411 as an example. This receiving base 44 is located in one of the 10 working areas 411. The receiving base 44 can receive the heating module 2 and / or the magnetic module 3, such as... Figure 14 As shown.

[0134] It should be understood that the number of work areas 411 is not a limitation of this invention, and can be adapted to other numbers according to actual needs.

[0135] For example, in an experiment involving the purification of DNA (Deoxyribonucleic acid) using the automated detection machine 4, when the well plate is placed in one of the working areas 411 of the detection platform 41, the detection platform 41 rotates to move the well plate below the multifunctional pipette 42 equipped with the heating module 2, meaning the axial direction (X-axis) of the multifunctional pipette 42 equipped with the heating module 2 is perpendicular to this working area 411. The heating module 2 is used to heat the sample in the well plate to a target temperature. The heating of the sample by the heating module 2 causes the double-stranded DNA to denature and generate single-stranded DNA, which is then used for subsequent experimental analysis. Furthermore, the heating module 2 is used to maintain the sample in the well plate at a target temperature so that the sample is kept at that target temperature for subsequent experiments.

[0136] When the well plate is placed in one of the working areas 411 of the detection platform 41, the detection platform 41 rotates to move the well plate below the multifunctional pipette 42 equipped with the magnetic module 3. When magnetic beads are added to the sample in the well plate and the magnetic beads adsorb the target DNA, the magnetic module 3 provides magnetic force to attract the magnetic beads with the target DNA, so as to retain the target DNA in the purification step. In addition, while the magnetic module 3 provides magnetic force to attract the magnetic beads with the target DNA, the moving mechanism 43 moves the multifunctional pipette 42 equipped with the magnetic module 3 to another working area 411, so that the magnetic beads with the target DNA attracted by the magnetic module 3 are moved to the other working area 411.

[0137] When the well plate is placed in one of the working areas 411 of the detection platform 41, the detection platform 41 rotates to displace this working area 411 below the multifunctional pipette 42 equipped with the magnetic module 3. The magnetic module 3 provides magnetic force to vibrate or stir the sample and analytical solution in the well plate, causing the sample and analytical solution to agitate and mix.

[0138] In one embodiment, during the optimization evaluation of the overall machine volume, compared to the volume of a conventional machine (86×75×60cm³), the automated testing machine 4 of the aforementioned embodiment reduces its volume to 73×75×50cm³ by removably assembling the heating module 2 and magnetic module 3 onto the pipette module 1 as needed. In other words, compared to the volume of a conventional machine, the automated testing machine 4 of the aforementioned embodiment reduces its volume by 29%.

[0139] In some embodiments, the multi-functional pipette 42 may be in manual form. See also Figure 15 A grip portion 6 is coupled to the side of the pipette housing 11 opposite to the side where the pipette connector 13 is located. The grip portion 6 is for the user to hold and control the piston action of the piston assembly 12 and regulate the drive of the heating module 2 (and magnetic module 3), so as to facilitate the hand-held use of the multifunctional pipette 42 in the external environment.

[0140] This describes the third application state. The pipette connector 13 on the pipette module 1 is designed for removable assembly of various sizes of micropipettes 5, such as... Figure 16As shown. When the micropipette tip 5 is fitted onto the pipette connector 13, the piston kinetic energy of the piston assembly 12 can draw liquid outside the micropipette tip 5 into the micropipette tip 5, or discharge liquid inside the micropipette tip 5 from its interior. As understood by those skilled in the art, the micropipette tip 5 is commercially available. Specifically, the linkage 16 can simultaneously pull the piston rods 123 of all piston assemblies 12 out of the air channel 122, so that the multifunctional pipette 42 draws liquid into the micropipette tip 5 mounted thereon; or, the linkage 16 can simultaneously push the piston rods 123 of all piston assemblies 12 into the air channel 122, so that the multifunctional pipette 42 discharges liquid from the micropipette tip 5 mounted thereon.

[0141] In summary, according to some embodiments, the multifunctional pipette 42, in addition to its functions of aspiration and dispensing, can be equipped with a heating module 2 to heat the sample, or a magnetic module 3 to provide a magnetic field, agitation, or stirring to the sample. Therefore, a single tool can provide multiple processing functions, simplifying the tools and / or instruments required for laboratory analysis, and even simplifying operating procedures and space requirements. According to some embodiments, the multifunctional pipette 42 can be used in automated testing machines 4, and the moving mechanism 43 enables the automatic assembly and replacement of the multifunctional pipette 42 between various functions, providing convenient and rapid automated operation for laboratory analysis while saving operating space.

Claims

1. A multifunctional pipette, comprising: The pipette module has multiple pipette connectors; A heating module having a first joint, the heating module being removably connected to the pipette module via the first joint and coupled to at least one of the plurality of pipette connectors; as well as A magnetic module having a second engagement portion, the magnetic module being removably connected to the pipette module by coupling to at least one of the plurality of pipette connectors via the second engagement portion; The pipette module further includes: a pipette housing, the plurality of pipette connectors being fixed to the pipette housing, wherein the plurality of pipette connectors define a plurality of first recesses relative to the plurality of pipette connectors, the first joint of the heating module having the plurality of first recesses, and each of the plurality of first recesses respectively matching the corresponding plurality of pipette connectors.

2. The multifunctional pipette as described in claim 1, wherein the pipette module further comprises: Multiple piston assemblies include multiple air passages and multiple piston rods, wherein one end of each of the multiple air passages has an opening, and each of the multiple piston rods is axially reciprocatingly inserted into each of the multiple air passages from the other end of each of the multiple air passages; Each of the plurality of piston assemblies is coupled to the corresponding plurality of suction tube connectors via the opening.

3. The multifunctional pipette of claim 2, wherein the plurality of piston assemblies are located within the pipette housing, and the openings of the plurality of piston assemblies are disposed near one side of the pipette housing.

4. The multifunctional pipette as described in claim 3, wherein the heating module further comprises: Multiple power supply terminals are located on the pipette housing; Multiple heating rods; as well as Multiple first connection terminals correspond to the multiple power supply terminals and are electrically connected to the multiple heating rods.

5. The multifunctional pipette of claim 4, wherein when the heating module receives one of the plurality of pipette connectors via at least one of the plurality of first recesses, the plurality of first connection ends are respectively electrically connected to the plurality of power supply ends.

6. The multifunctional pipette of claim 5, wherein the heating module further includes a heat-resistant housing, wherein the first joint is located on one side of the heat-resistant housing, the plurality of heating rods are disposed opposite to the first joint, wherein the plurality of first connecting ends are embedded in the heat-resistant housing, and the plurality of first connecting ends and the first joint face the same direction.

7. The multifunctional pipette of claim 6, wherein the heat-resistant housing comprises: A heat-resistant housing fixing base includes a first joint portion and a second surface of the heat-resistant housing that are opposite to each other, and a third surface and a fourth surface of the heat-resistant housing that are connected between the first joint portion and the second surface of the heat-resistant housing, wherein a plurality of heating rods are inserted through the second surface and the plurality of heating rods are respectively aligned with the plurality of first recesses; and At least two heat-resistant housing extension arms, wherein at least one of the plurality of heat-resistant housing extension arms is connected at one end to the third surface of the heat-resistant housing, and at least another of the plurality of heat-resistant housing extension arms is connected at one end to the fourth surface of the heat-resistant housing, and the other end of each plurality of heat-resistant housing extension arms faces the direction in which the first joint faces, wherein the plurality of first connecting ends are respectively located on the end face of the other end of the plurality of heat-resistant housing extension arms.

8. The multifunctional pipette of claim 1, wherein the magnetic module comprises: Multiple connecting sleeves, having the second joint portion, wherein the second joint portion is composed of multiple sleeve recesses, each of the multiple sleeve recesses being located at one end of each of the multiple connecting sleeves, wherein the multiple straw connectors define the multiple sleeve recesses relative to the multiple straw connectors, and the multiple sleeve recesses respectively match the corresponding multiple straw connectors. as well as Multiple permanent magnet rods are respectively set on the other end of the corresponding multiple connecting sleeves.

9. The multifunctional pipette of claim 1, wherein the magnetic module comprises: A magnetic module fixing base includes a second joint portion and a second surface of a magnetic module that are opposite to each other, wherein the second joint portion has a plurality of second recesses of the magnetic module, wherein the plurality of straw connectors define the plurality of second recesses of the magnetic module relative to the plurality of straw connectors, and the plurality of second recesses of the magnetic module respectively match the plurality of straw connectors. as well as Multiple permanent magnet rods are inserted through the second surface of the magnetic module, wherein the multiple permanent magnet rods are respectively aligned with the multiple second recesses of the magnetic module.

10. The multifunctional pipette of claim 3, wherein the magnetic module comprises: Multiple magnetic module second recesses, wherein the multiple magnetic module second recesses are located at the second joint, wherein the multiple straw connectors define the multiple magnetic module second recesses relative to the multiple straw connectors, and the multiple magnetic module second recesses respectively match the corresponding multiple straw connectors. Multiple power supply terminals are located on the pipette housing; Multiple electromagnet rods are disposed relative to the second joint portion, wherein the multiple electromagnet rods are respectively aligned with the second recesses of the multiple magnetic modules. and Multiple second connection terminals are respectively corresponding to the multiple power supply terminals and electrically connected to the multiple electromagnet rods, wherein the multiple second connection terminals and the second joint face the same direction.

11. The multifunctional pipette of claim 10, wherein when the magnetic module receives one of the plurality of pipette connectors via at least one of the plurality of magnetic module second recesses, the plurality of second connection ends are respectively electrically connected to the plurality of power supply ends.

12. The multifunctional pipette of claim 10, wherein the magnetic module further comprises a connecting housing, the connecting housing comprising: A connecting housing fixing base includes a second joint portion and a second surface of the connecting housing that are opposite to each other, and a third surface and a fourth surface of the connecting housing that are connected between the second joint portion and the second surface of the connecting housing, wherein the plurality of electromagnet rods pass through the second surface of the connecting housing; and At least two connecting housing extension arms, at least one of the plurality of connecting housing extension arms is connected at one end to the third surface of the connecting housing, and at least another of the plurality of connecting housing extension arms is connected at one end to the fourth surface of the connecting housing, and the other end of each plurality of connecting housing extension arms faces the direction in which the second joint portion faces, wherein the plurality of second connecting ends are respectively located on the end face of the other end of the plurality of connecting housing extension arms.

13. The multifunctional pipette of claim 2, wherein the pipette module further comprises: Linear guide rail; and The linkage connects the linear guide rail and the plurality of piston assemblies, thereby driving the plurality of piston assemblies to reciprocate along the linear guide rail.

14. The multifunctional pipette of claim 13, wherein the pipette module further comprises: A limiting component, connected to the linkage, is used to limit the movement distance of the linkage.

15. The multifunctional pipette of claim 3, wherein the pipette module further comprises: A motor, located on one side of the pipette housing, is used to drive the plurality of piston assemblies.

16. The multifunctional pipette of claim 1, wherein the pipette module further comprises: The exit structure is located next to the multiple straw connectors.

17. The multifunctional pipette of claim 16, wherein the withdrawal structure comprises: Multiple perforations are formed on the exit structure, wherein each of the multiple perforations surrounds each of the multiple straw connectors.

18. An automated inspection machine, comprising: The testing platform has multiple work areas; Multifunctional pipette, including: The pipette module has multiple pipette connectors; A heating module having a first engagement portion, the heating module being removably connected to the pipette module via the first engagement portion and coupled to at least one of the plurality of pipette connectors; and A magnetic module having a second engagement portion, the magnetic module being removably connected to the pipette module via the second engagement portion and coupled to at least one of the plurality of pipette connectors; and A moving mechanism, connected to the multi-functional pipette, is used to move the multi-functional pipette between the multiple work areas. The pipette module further includes: a pipette housing, the plurality of pipette connectors being fixedly disposed in the pipette housing, wherein the plurality of pipette connectors define a plurality of first recesses relative to the plurality of pipette connectors, the first joint having the plurality of first recesses, and each of the plurality of first recesses respectively matching the corresponding plurality of pipette connectors.

19. The automated inspection machine as described in claim 18, further comprising: A storage base, located in one of the multiple working areas, is used to store the heating module or the magnetic module.

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