Medicine for treating herpes zoster and preparation method thereof

Abstract

The invention discloses a medicine for treating herpes zoster. The medicine is prepared from Viola yedoensis, chrysanthemum, honeysuckle, forsythia, Rehmannia root, pyrrosia, honeysuckle vine, white peony root, gentiana macrophylla, Chinese angelica, and Ligusticum chuanxiong. The medicine has the effects of clearing the liver and purging fire, clearing heat and detoxifying, promoting dampness and unblocking the meridians, and is used to treat herpes zoster with liver and gallbladder damp-heat syndrome. The medicine is suitable for people suffering from herpes zoster with liver and gallbladder damp-heat syndrome accompanied by bitter taste in the mouth, dry throat, irritability, yellow urine, dry stool, red tongue, thin yellow or thick yellow fur, and a stringy, slippery, and rapid pulse.

Description

Field of the Invention

[0001] The invention relates to a medicine for treating herpes zoster and a preparation method thereof, and belongs to the field of pharmaceutical technology. Background Art

[0002] Herpes zoster, also known as herpes zoster, is an acute inflammatory skin disease caused by the varicella-zoster virus. Its main characteristic is clustered blisters distributed in a band-like pattern along a peripheral nerve, accompanied by significant neuralgia. It occurs most frequently in spring and autumn, and is more common in adults. The virus enters the human body through the respiratory mucosa, spreads through the bloodstream, and causes chickenpox to appear on the skin. However, most people do not develop chickenpox after being infected. This is a latent infection and they become carriers of the virus. This virus is neurotropic. After invading the sensory nerve endings of the skin, it can move along the nerves to the ganglia of the posterior roots of the spinal cord and lurk there. When the host's cellular immune function is low, such as when suffering from a cold, fever, systemic lupus erythematosus, and malignant tumors, the virus is stimulated again, causing inflammation and necrosis of the ganglia. At the same time, the reactivated virus can move along the peripheral nerve fibers to the skin to cause herpes. In rare cases, the herpes virus can spread to the anterior horn cells of the spinal cord and visceral nerve fibers, causing motor nerve paralysis, such as facial nerve paralysis, as well as paralysis symptoms of the gastrointestinal tract and urinary tract.

[0003] Traditional Chinese Medicine believes that patients with herpes zoster experience both internal and external symptoms, with a mixture of deficiency and excess. Therefore, syndrome differentiation requires careful and rigorous analysis, not rigid adherence. It requires a combination of deficiency and excess, with flexible adjustments and adjustments tailored to the patient's specific symptoms. Herpes zoster can be divided into three main types based on the patient's presentation: liver-gallbladder damp-heat, spleen deficiency and dampness accumulation, and meridian stasis. In the liver-gallbladder damp-heat type, dampness and heat are present in the early stages of the disease, often with stagnation of fire toxins in the skin. This manifests primarily as erythema, often accompanied by palpable blisters with tense walls and a burning, stinging sensation. Some patients also experience restlessness and insomnia, as well as bitter taste in the mouth, dry throat, dark urine, and constipation. Treatment is with fire-clearing, liver-soothing, and heat-clearing and detoxifying drugs. In the spleen deficiency and dampness accumulation type, signs of fire toxins are less pronounced, but there are signs of severe spleen deficiency. Some patients experience pallor and clustered blisters with loose walls, erosion, and abundant exudate, but with less severe pain. Therefore, treatment for this type of patient requires alleviating spleen and stomach deficiency, adhering to the principle of clearing dampness and toxins. Detoxification and pain relief through spleen-strengthening and diuretic therapies are recommended. Patients with meridian stasis can present with two types of pain: pain due to qi stagnation and blood stasis, and pain due to qi deficiency and lack of vitality. Therefore, treatment should adhere to the principles of regulating qi, activating blood circulation, and removing stasis, promoting meridian dredging and pain relief.

[0004] Currently, Western medicine typically uses acyclovir tablets, valacyclovir hydrochloride dispersible tablets, and other medications for treatment after diagnosis. Although these medications are effective quickly, they are prone to recurring attacks. The present invention, based on Traditional Chinese Medicine (TCM), targets liver-gallbladder damp-heat syndrome. The invention's medication can clear the liver and purge fire, clear away heat and toxic substances, promote dampness and dredge the meridians, and relieve pain. It can completely eliminate herpes simplex virus from the human body, preventing the possibility of recurring attacks. The invention is suitable for people suffering from herpes simplex virus with liver-gallbladder damp-heat syndrome. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a drug for treating herpes zoster and a method for preparing the drug. The drug has the efficacy of clearing the liver and purging fire, clearing heat and detoxifying, and promoting dampness and dredging the meridians, and is used to treat herpes zoster. It is suitable for people suffering from herpes zoster caused by liver and gallbladder damp-heat syndrome.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] A medicine for treating herpes zoster. The medicinal active ingredients of the medicine are calculated by weight as follows: 200-400 parts of Viola yedoensis, 60-140 parts of chrysanthemum, 100-200 parts of honeysuckle, 100-200 parts of forsythia, 80-160 parts of rehmannia root, 60-140 parts of pyrrosia, 150-250 parts of honeysuckle vine, 60-140 parts of white peony root wine, 60-140 parts of gentiana macrophylla, 60-140 parts of angelica sinensis, and 40-80 parts of ligusticum chuanxiong.

[0008] The above-mentioned medicine for treating herpes zoster, whose medicinal active ingredients are calculated by weight: 250-350 parts of Viola yedoensis, 80-120 parts of chrysanthemum, 130-170 parts of honeysuckle, 130-170 parts of forsythia, 100-140 parts of Rehmannia root, 80-120 parts of Pyrola, 170-230 parts of Lonicera japonica, 80-120 parts of white peony root, 80-120 parts of Gentiana macrophylla, 80-120 parts of Chinese angelica, and 50-70 parts of Chuanxiong.

[0009] Specifically, the aforementioned medicine for treating herpes zoster, its medicinal active ingredients are calculated by weight: 300 parts of Viola yedoensis, 100 parts of chrysanthemum, 150 parts of honeysuckle, 150 parts of forsythia, 120 parts of Rehmannia root, 100 parts of Pyrola, 200 parts of Lonicera japonica, 100 parts of white peony root, 100 parts of Gentiana macrophylla, 100 parts of Angelica sinensis, and 60 parts of Chuanxiong.

[0010] The preparation method of the above-mentioned medicine for treating herpes zoster is to weigh all the medicinal materials in the prescription according to the proportion, and process them according to the conventional preparation method to prepare the corresponding pharmaceutical preparation.

[0011] Specifically, the preparation method of the above-mentioned medicine for treating herpes zoster is to weigh all the medicinal materials in the prescription according to the proportion, crush them and mix them evenly, add water and boil them to obtain a decoction, and process it according to the conventional preparation method to prepare the corresponding drug preparation.

[0012] The aforementioned pharmaceutical preparations include decoctions, hard capsules, tablets, granules, oral liquids or syrups.

[0013] The above-mentioned decoction is prepared as follows: weigh each medicinal material according to the prescription ratio, add 10 times the amount of water to soak for 0.5h, and then decoct three times, each time for 1h. The three decoctions are combined and mixed. When it is concentrated to 80% of the original medicinal solution, it is filtered while hot. The filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. Take 2000 grams of honey (refined honey) and slowly add it to the above extract. Stir evenly and continue to heat over low heat to collect the paste. When a small amount can be pulled into a thread or dropped on paper without leaving any water marks, stir evenly, put it into a sterile bottle and seal it.

[0014] The hard capsules are prepared as follows: the medicinal materials are weighed according to the prescribed ratio, soaked in 8 times the amount of water for 0.5 hours, and then decocted twice, each time for 1.5 hours. The two decoctions are combined and mixed, and concentrated to 80% of the original medicinal solution. The filtrate is filtered while hot, and the filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. The extract is stirred evenly, dried at 80-90°C to obtain a dry extract, pulverized into a fine powder, and 10% of the prepared amount of pregelatinized starch is added and mixed evenly. The extract is granulated with 75% ethanol, dried, sized, and filled into capsules.

[0015] The tablets are prepared as follows: weigh each medicinal material according to the prescription ratio, add 6 times the amount of water to soak for 0.5h, and then decoct three times, each time for 1.5h. The two decoctions are combined and mixed. When the decoctions are concentrated to 80% of the original medicinal solution, they are filtered while hot. The filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. The extract is stirred evenly, dried at 80-90°C, and crushed into fine powder to obtain a dry extract. The dry extract is taken and 10% of a mixed excipient is added. The mixed excipient is prepared by mixing a paste and sodium carboxymethyl cellulose in a ratio of 2:1. The granules are granulated with 75% ethanol as a wetting agent, dried, tableted, and film-coated to obtain the tablets.

[0016] The granules are prepared as follows: weigh each medicinal material according to the prescription ratio, soak it in 12 times the amount of water for 0.5 hours, and then decoct it twice, each time for 2 hours. The three decoctions are combined and mixed. When it is concentrated to 80% of the original medicinal solution, it is filtered while hot. The filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. The extract is stirred evenly, dried at 80-90°C, and crushed into a fine powder to obtain a dry extract. Take 1 part of the dry extract and 2 parts of sucrose, and use 75% ethanol as a wetting agent to prepare granules. After the granules are prepared, dry them at 80°C, pass them through a 16-mesh sieve once, and separate the fine powder through an 80-mesh sieve.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The drug for treating herpes zoster is prepared from Viola yedoensis, chrysanthemum, honeysuckle, forsythia, Rehmannia root, Pyrola, honeysuckle vine, white peony root, gentiana macrophylla, Chinese angelica, and Chuanxiong. The properties and efficacy of each component are as follows: Viola yedoensis is the dried whole herb of the Viola yedoensis plant (Violaceae family); it has a bitter and pungent taste and a cold nature; it enters the heart and liver meridians; it has the effects of clearing heat and detoxifying, cooling blood and reducing swelling; it is used for furuncles, carbuncles, back ulcers, erysipelas, and snake bites. Chrysanthemum is the dried inflorescence of Chrysanthemum morifolium Ramat. (Asteraceae family); it has a sweet and bitter taste and a slightly cold nature; it enters the lung and liver meridians; it has the effects of dispersing wind and heat, calming the liver and improving eyesight, and clearing heat and detoxifying; it is used for wind-heat colds, headaches and dizziness, red and swollen eyes, blurred vision, and sores, carbuncles, and swelling. Honeysuckle is the dried buds or early blooming flowers of Lonicera japonica Thunb., a plant of the Caprifoliaceae family. Harvested in early summer before the flowers open and dried, it has a sweet flavor and a cold nature. It enters the lung, heart, and stomach meridians, clearing away heat and detoxifying, and dispersing wind-heat. It is used to treat carbuncles, furuncles, sore throat, erysipelas, dysentery caused by heat toxins, wind-heat colds, and fevers due to febrile diseases. Pyrrosia lingua (Thunb.) Farw., a medium-sized epiphytic fern of the Polypodiaceae family and genus Pyrrosia, has a bitter and sweet flavor and a cool nature. It enters the lung and bladder meridians, promoting diuresis and relieving stranguria, clearing the lungs and relieving heat. It is used to treat painful stranguria, hematuria, urinary tract stones, nephritis, metrorrhagia, dysentery, lung-heat coughs, chronic tracheitis, wounds, and carbuncles. Cooked Rehmannia glutinosa is the fresh or dried root tuber of Rehmannia glutinosa Libosch., a plant of the Scrophulariaceae family. It is harvested in autumn, the rhizome and mud and sand removed, and slowly baked until it is about 80% dry. The former is commonly known as "fresh Rehmannia glutinosa" and the latter is commonly known as "raw Rehmannia glutinosa." This product is a processed product of raw Rehmannia glutinosa. It tastes sweet and is slightly warm in nature. It enters the liver and kidney meridians and has the effects of nourishing blood and yin, replenishing essence and filling marrow. It is used for blood deficiency and sallow complexion, palpitations, irregular menstruation, metrorrhagia, liver and kidney yin deficiency, soreness of the waist and knees, bone steaming and hot flashes, night sweats and spermatorrhea, internal heat and thirst, dizziness, tinnitus, and premature graying of hair. Forsythia suspensa (Thunb.) Vahl, a plant of the Oleaceae family, is a dried fruit. It tastes bitter and is slightly cold in nature. It enters the lung, heart, and small intestine meridians. It has the effects of clearing heat and detoxifying, reducing swelling and dispersing stagnation, and dispersing wind-heat. It is used for carbuncle, scrofula, mastitis, erysipelas, wind-heat cold, the initial stage of febrile disease, the invasion of warm heat into the Ying meridians, high fever, thirst, coma, rash, and painful stranguria caused by heat. Honeysuckle vine is the dried stems and branches of Lonicera japonica Thunb., a plant of the Caprifoliaceae family. It tastes sweet and is cold in nature. It enters the lung and stomach meridians. It has the effects of clearing heat and detoxifying, dispersing wind and unblocking the meridians. It is used for fever caused by febrile disease, dysentery caused by heat toxins, carbuncle, sores, rheumatic arthralgia due to heat, and red, swollen, hot, and painful joints.White peony root is the dried root of Paeonia lactiflora Pall., a plant of the Ranunculaceae family. To prepare white peony root with wine, clean white peony slices are stir-fried according to the wine-roasting method (General Rule 0213) until slightly yellow. It tastes bitter, sour, and has a slight wine aroma, and is slightly cold in nature. It enters the liver and spleen meridians and has the effects of nourishing blood and regulating menstruation, astringing yin and stopping sweating, softening the liver and relieving pain, and calming liver yang. It is used for sallow complexion caused by blood deficiency, irregular menstruation, spontaneous sweating, night sweats, flank pain, abdominal pain, cramps in the limbs, headache, and dizziness. Gentiana macrophylla is the dried root of Gentiana macrophylla Pall., Gentianastraminea Maxim., Gentiana crassicaulis Duthie ex Burk., or Gentiana dahurica Fisch., all plants of the Gentianaceae family. The first three are commonly known as "Qinjiao" and "Mahuajiao" according to their different properties, while the latter is commonly known as "Xiaoqinjiao." It tastes pungent and bitter and is neutral in nature. It enters the stomach, liver, and gallbladder meridians and has the effects of relieving rheumatism, clearing damp-heat, relieving pain, and relieving fever. It is used to treat rheumatic pain, hemiplegia caused by stroke, muscle spasms, joint pain, damp-heat jaundice, hot flashes due to bone steaming, and fever caused by malnutrition in children. Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a plant in the Umbelliferae family. It has a sweet and pungent taste and is warm in nature. It enters the liver, heart, and spleen meridians and has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements. It is used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic pain, injuries from falls, carbuncles, sores, and constipation caused by dry intestines. Angelica sinensis wine promotes blood circulation and regulates menstruation and is used for amenorrhea and dysmenorrhea, rheumatic pain, and injuries from falls. Chuanxiong is the dried rhizome of Ligusticum chuanxiong Hort., a plant in the Umbelliferae family. It has a pungent taste and is warm in nature. It enters the liver, gallbladder, and pericardium meridians and has the effects of promoting blood circulation and qi circulation, dispelling wind and relieving pain. It is used for chest pain, heart pain, stabbing pain in the chest and ribs, swelling and pain from falls, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to lumps, headaches, and rheumatic pain.

[0019] Explanation:

[0020] The monarch and ministerial herbs: Viola yedoensis and chrysanthemum clear the liver and purge fire, clearing heat and detoxifying, and are used to relieve the symptoms of liver heat stagnation in herpes zoster. Honeysuckle and forsythia suspensa, one cold and one cool, are paired together to clear heat and detoxify, and dispel wind-heat more effectively. They are the ministerial herbs. Together with the monarch herbs, they form the modified Wuwei Xiaodu Yin formula, which helps clear the liver and purge fire, clear heat and detoxify. The monarch and ministerial herbs treat the toxicity.

[0021] Adjuvants: Selaginella and Gentiana macrophylla are used to clear excess fire in the liver and lungs, clear heat, promote dampness, dredge the meridians, and relieve pain; this is treating dampness from the inside. Rehmannia root, white peony root, Chuanxiong, and Chinese angelica root in the formula form the Four Substances Decoction, which nourishes and activates blood circulation, moistens dryness and dispels wind. It clears heat, detoxifies, and disperses the bitter, dry, and yin-damaging toxins of the monarch and ministerial ingredients in the formula, removing the toxicity and retaining the beneficial effects. The Four Substances Decoction nourishes the blood to nourish the skin, removes rot, promotes toxins, and regenerates muscle tissue, activating blood circulation to dredge the tendons and meridians, alleviating pain; this is treating blood from the inside.

[0022] Assistant drug: Honeysuckle vine goes to the surface, uses the vine to open up the meridians, and guides all the drugs directly to the diseased area. This is treatment according to the meridians.

[0023] The whole prescription has the functions of clearing the liver and purging fire, clearing away heat and detoxifying, promoting dampness and unblocking meridians to relieve pain, so as to treat herpes zoster with damp-heat syndrome of liver and gallbladder. It is suitable for people suffering from herpes zoster with damp-heat syndrome of liver and gallbladder accompanied by bitter taste in the mouth, dry throat, irritability, yellow urine, dry stool, red tongue, thin yellow or thick yellow fur, and stringy, slippery and rapid pulse. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 :Typical case 1 outpatient case;

[0025] Figure 2 : Photos of typical case 1 before treatment;

[0026] Figure 3 : Photos of typical case 1 after treatment;

[0027] Figure 4 : Typical case 2 outpatient case;

[0028] Figure 5 : Photos of typical case 2 before treatment;

[0029] Figure 6 : Photos of typical case 2 after treatment;

[0030] Figure 7 : Typical case 3 outpatient case;

[0031] Figure 8 : Photos of typical case 3 before treatment;

[0032] Figure 9 : Photos of typical case 3 after treatment; DETAILED DESCRIPTION

[0033] The present invention will be further described below with reference to the examples, but they are not intended to limit the present invention.

[0034] Example 1.

[0035] Prescription: 300g of Viola yedoensis, 100g of chrysanthemum, 150g of honeysuckle, 150g of forsythia, 120g of Rehmannia root, 100g of Peltierella fragrans, 200g of Lonicera japonica, 100g of white peony root, 100g of Gentiana macrophylla, 100g of Chinese angelica, and 60g of Ligusticum chuanxiong.

[0036] Process: Weigh each medicinal material according to the prescription ratio, add 10 times the amount of water to soak for 0.5h, then decoct 3 times, each time for 1h, combine the three decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70℃. Take 2000g of honey (refined honey) and slowly add it to the above extract, stir evenly, continue to heat over low heat to collect the paste, wait until a small amount can be pulled into a thread, or when it is dropped on paper and no water marks are left, stir evenly, put it into a sterile bottle and seal it to obtain the decoction paste.

[0037] Dosage and Administration: Take with boiled water, three times a day, 20g each time, dissolve in hot water and take orally; can also be swallowed directly; 7 days is a course of treatment.

[0038] Example 2.

[0039] Prescription: 200g of Viola yedoensis, 60g of chrysanthemum, 100g of honeysuckle, 100g of forsythia, 80g of Rehmannia root, 60g of Peltierella fragrans, 150g of Lonicera japonica, 60g of white peony root, 60g of Gentiana macrophylla, 60g of Chinese angelica, and 40g of Ligusticum chuanxiong.

[0040] Process: Weigh each medicinal material according to the prescription ratio, add 8 times the amount of water to soak for 0.5h, and then decoct twice, each time for 1.5h. Combine the two decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70°C. Stir well, dry at 80-90°C to obtain a dry extract, grind into fine powder, add 10% of the preparation amount of pregelatinized starch and mix well. Granulate with 75% ethanol, dry, re-granulate, and fill into capsules to obtain hard capsules.

[0041] Dosage and Administration: Take with boiled water, 3 times a day, 3-5 tablets each time (0.4g / tablet); 7 days as a course of treatment.

[0042] Example 3.

[0043] Prescription: 400g of Viola yedoensis, 140g of Chrysanthemum, 200g of Honeysuckle, 200g of Forsythia, 160g of Rehmannia root, 140g of Peltierella fragrans, 250g of Lonicera japonica, 140g of White Peony Root, 140g of Gentiana macrophylla, 140g of Angelica sinensis, and 80g of Ligusticum chuanxiong.

[0044] Process: Weigh each medicinal material according to the prescription ratio, add 6 times the amount of water to soak for 0.5h, and then decoct 3 times, each time for 1.5h. Combine the two decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70℃. Stir evenly, dry the extract at 80-90℃, and grind it into fine powder to obtain dry extract. Take the dry extract, add 10% mixed excipients, the mixed excipients are made by mixing paste and sodium carboxymethyl cellulose in a ratio of 2:1, granulate with 75% ethanol as a wetting agent, dry, tablet, and film coat to obtain tablets.

[0045] Dosage and Administration: Oral administration, 3 times a day, 3-5 tablets each time (0.4g / tablet); 7 days as a course of treatment.

[0046] Example 4.

[0047] Prescription: Viola yedoensis 280g, chrysanthemum 60g, honeysuckle 200g, forsythia suspensa 120g, rehmannia root 110g, pyrrosia 70g, honeysuckle 230g, white peony root 140g, gentiana macrophylla 100g, angelica sinensis 80g, ligusticum 50g.

[0048] Process: Weigh each medicinal material according to the prescription ratio, add 12 times the amount of water to soak for 0.5h, and then decoct twice, each time for 2h. Combine the three decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70℃. Stir evenly, dry the extract at 80-90℃, and grind it into fine powder to obtain dry extract. Take 1 part of dry extract and 2 parts of sucrose, use 75% ethanol as a wetting agent to prepare granules, dry at 80℃ after the granules are prepared, pass through a 16-mesh sieve once, and use an 80-mesh sieve to separate the fine powder to obtain granules.

[0049] Dosage and administration: Oral administration, 15 grams at a time, 3 times a day; one course of treatment is 7 days.

[0050] Example 5.

[0051] Prescription: 350g of Viola yedoensis, 120g of chrysanthemum, 100g of honeysuckle, 180g of forsythia, 70g of Rehmannia root, 130g of Peltierella fragrans, 200g of Lonicera japonica, 70g of white peony root, 60g of Gentiana macrophylla, 140g of Chinese angelica, and 80g of Ligusticum chuanxiong.

[0052] Process: Weigh each medicinal material according to the prescription ratio, add 10 times the amount of water to soak for 0.5h, then decoct 3 times, each time for 1h, combine the three decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70℃. Take 2000g of honey (refined honey) and slowly add it to the above extract, stir evenly, continue to heat over low heat to collect the paste, wait until a small amount can be pulled into a thread, or when it is dropped on paper and no water marks are left, stir evenly, put it into a sterile bottle and seal it to obtain the decoction paste.

[0053] Dosage and Administration: Take with boiled water, three times a day, 20g each time, dissolve in hot water and take orally; can also be swallowed directly; 7 days is a course of treatment.

[0054] Example 6.

[0055] Prescription: Viola yedoensis 240g, chrysanthemum 120g, honeysuckle 180g, forsythia suspensa 170g, rehmannia root 90g, pyrrosia 140g, honeysuckle 150g, white peony root 80g, gentiana macrophylla 70g, angelica 130g, ligusticum 40g.

[0056] Process: Weigh each medicinal material according to the prescription ratio, add 8 times the amount of water to soak for 0.5h, and then decoct twice, each time for 1.5h. Combine the two decoctions, mix well, and concentrate to 80% of the original medicinal solution. Filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70°C. Stir well, dry at 80-90°C to obtain a dry extract, grind into fine powder, add 10% of the preparation amount of pregelatinized starch and mix well. Granulate with 75% ethanol, dry, re-granulate, and fill into capsules to obtain hard capsules.

[0057] Dosage and Administration: Take with boiled water, 3 times a day, 3-5 tablets each time (0.4g / tablet); 7 days as a course of treatment.

[0058] Typical Cases

[0059] Typical case 1:

[0060] The patient, Zhang, female, 41 years old, visited our outpatient clinic on January 11, 2024 because of "clustered skin lesions on the top of the head and neck, redness, swelling, heat and pain, deep red color, red tongue, slightly greasy yellow tongue coating, and stringy pulse."

[0061] TCM diagnosis: Herpes zoster (liver and gallbladder damp-heat syndrome).

[0062] Treatment prescription: Viola yedoensis 30g, chrysanthemum 10g, honeysuckle 15g, forsythia suspensa 15g, rehmannia root 12g, stonecrop 10g, honeysuckle 20g, white peony root 10g, gentiana macrophylla 10g, angelica 10g, ligusticum 6g.

[0063] 7 sets of Chinese medicine, one dose per day (divided into three times), for oral administration.

[0064] Before and after treatment comparison Figure 2 、 Figure 3 .

[0065] Typical case 2:

[0066] Patient Wang, male, 73 years old, visited our outpatient clinic on January 8, 2024 due to "clustered skin lesions in the area along the gallbladder meridian on the inner side of the right lower limb, redness, swelling, heat and pain, deep red color, red tongue, slightly greasy yellow tongue coating, and stringy pulse."

[0067] TCM diagnosis: Herpes zoster (liver and gallbladder damp-heat syndrome).

[0068] Western medicine diagnosis: Herpes zoster neuralgia.

[0069] Treatment prescription: Viola yedoensis 30g, chrysanthemum 10g, honeysuckle 15g, forsythia suspensa 15g, rehmannia root 12g, white peony root 10g, honeysuckle 20g, stonecrop 10g, gentiana macrophylla 10g, angelica 10g, ligusticum 6g.

[0070] 7 sets of Chinese medicine, one dose per day (divided into three times), for oral administration.

[0071] Before and after treatment comparison Figure 5 、 Figure 6 .

[0072] Typical case 3:

[0073] A 42-year-old female patient, surnamed Wang, presented to our outpatient clinic on December 26, 2023, with a one-week history of red, vesicular papules on the left side of her head, accompanied by stinging pain for another week, which worsened over the past two days. Her current medical history: A week prior, a red papule developed on the left side of her head, accompanied by burning pain, which was not relieved by self-administered analgesics. Two days prior, the pain worsened, with an increase in the number of papules and blisters on the left side of her head, intensified pain, and a stinging sensation that was untouchable.

[0074] Past history: good health

[0075] Epidemiological history: None

[0076] Allergy history: None

[0077] TCM diagnosis: Herpes zoster (liver and gallbladder damp-heat syndrome).

[0078] Western medicine diagnosis: Herpes zoster neuralgia.

[0079] Treatment prescription: Viola yedoensis 30g, chrysanthemum 10g, honeysuckle 15g, forsythia suspensa 15g, rehmannia root 12g, white peony root 10g, honeysuckle 20g, stonecrop 10g, gentiana macrophylla 10g, angelica 10g, ligusticum 6g.

[0080] 7 sets of Chinese medicine, one dose per day (divided into three times), for oral administration.

[0081] Before and after treatment comparison Figure 8 、 Figure 9 .

Claims

1. A medicine for treating herpes zoster, characterized in that: The medicinal active ingredients are calculated by weight as follows: 200-400 parts of Viola yedoensis, 60-140 parts of chrysanthemum, 100-200 parts of honeysuckle, 100-200 parts of forsythia, 80-160 parts of rehmannia root, 60-140 parts of pyrrosia, 150-250 parts of honeysuckle vine, 60-140 parts of white peony root, 60-140 parts of gentiana macrophylla, 60-140 parts of angelica sinensis and 40-80 parts of ligusticum chuanxiong.

2. The drug for treating herpes zoster as claimed in claim 1, wherein: The medicinal active ingredients are calculated by weight as follows: 250-350 parts of Viola yedoensis, 80-120 parts of chrysanthemum, 130-170 parts of honeysuckle, 130-170 parts of forsythia, 100-140 parts of rehmannia root, 80-120 parts of pyrrosia, 170-230 parts of honeysuckle vine, 80-120 parts of white peony root, 80-120 parts of gentiana macrophylla, 80-120 parts of angelica sinensis and 50-70 parts of ligusticum chuanxiong.

3. The drug for treating herpes zoster according to claim 1 or 2, characterized in that: The medicinal active ingredients are calculated by weight and are prepared from 300 parts of Viola yedoensis, 100 parts of chrysanthemum, 150 parts of honeysuckle, 150 parts of forsythia, 120 parts of rehmannia root, 100 parts of pyrrosia, 200 parts of honeysuckle vine, 100 parts of white peony root, 100 parts of gentiana macrophylla, 100 parts of angelica sinensis and 60 parts of ligusticum chuanxiong.

4. A method for preparing a medicament for treating herpes zoster as claimed in any one of claims 1 to 3, characterized in that: All medicinal materials in the prescription are weighed in proportion, and processed according to conventional preparation methods to prepare corresponding pharmaceutical preparations.

5. The method for preparing the medicine for treating herpes zoster as claimed in claim 4, characterized in that: All the medicinal materials in the prescription are weighed in proportion, crushed and mixed evenly, then added with water and boiled to obtain a decoction, which is then processed according to conventional preparation methods to prepare the corresponding pharmaceutical preparation.

6. The method for preparing the medicine for treating herpes zoster as claimed in claim 5, characterized in that: The pharmaceutical preparations include decoctions, hard capsules, tablets, granules, oral liquids or syrups.

7. The method for preparing the medicine for treating herpes zoster as claimed in claim 6, characterized in that: The decoction is prepared as follows: weigh each medicinal material according to the prescription ratio, add 10 times the amount of water to soak for 0.5h, and then decoct for 3 times, each time for 1h, combine the three decoctions, mix evenly, and concentrate to 80% of the original medicinal solution, filter while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70°C. Take 2000g of refined honey, slowly add it to the above extract, stir evenly, continue to heat with low heat to collect the paste, wait until a small amount can be pulled into a thread, or when it is dropped on paper and no water marks are left, stir evenly, put it into a sterile bottle and seal it.

8. The method for preparing the medicine for treating herpes zoster as claimed in claim 6, characterized in that: The hard capsule is prepared as follows: weigh each medicinal material according to the prescription ratio, add 8 times the amount of water to soak for 0.5 hours, and then decoct twice, each time for 1.5 hours. The two decoctions are combined and mixed, and concentrated to 80% of the original medicinal solution. The mixture is filtered while hot, and the filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. The extract is stirred evenly, dried at 80-90°C to obtain a dry extract, crushed into fine powder, added with 10% of the preparation amount of pregelatinized starch, mixed evenly, granulated with 75% ethanol, dried, granulated, and filled into capsules to obtain the hard capsule.

9. The method for preparing the medicine for treating herpes zoster as claimed in claim 6, characterized in that: The tablets are prepared as follows: weighing each medicinal material according to the prescription ratio, adding 6 times the amount of water to soak for 0.5h, and then decocting three times, each time for 1.5h, combining the two decoctions, mixing, and concentrating to 80% of the original medicinal solution, filtering while hot, and concentrating the filtrate to an extract with a relative density of 1.10-1.20 at 70°C, stirring evenly, drying the extract at 80-90°C, and crushing it into fine powder to obtain a dry extract, taking the dry extract, adding 10% of a mixed excipient, the mixed excipient being prepared by mixing a paste and sodium carboxymethyl cellulose in a ratio of 2:1, granulating with 75% ethanol as a wetting agent, drying, tableting, and film coating to obtain the tablets.

10. The method for preparing the medicine for treating herpes zoster as claimed in claim 6, characterized in that: The granules are prepared as follows: weighing each medicinal material according to the prescription ratio, adding 12 times the amount of water to soak for 0.5h, and then decocting twice, each time for 2h, combining the three decoctions, mixing, and concentrating to 80% of the original medicinal solution, filtering while hot, and concentrating the filtrate to an extract with a relative density of 1.10-1.20 at 70°C, stirring evenly, drying the extract at 80-90°C, and crushing it into fine powder to obtain a dry extract, taking 1 part of the dry extract and 2 parts of sucrose, using 75% ethanol as a wetting agent to prepare granules, drying at 80°C after the granules are prepared, passing through a 16-mesh sieve once, and separating the fine powder with an 80-mesh sieve to obtain the granules.

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