A composition for relieving allergies, stopping itching, and improving rough skin, its preparation method, and its application.

Abstract

This invention discloses a composition for relieving allergies, itching, and improving rough skin, its preparation method, and its application. The composition comprises the following active ingredients: asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. This invention prepares the composition using raw materials and proportions containing asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. The synergistic effect between these components results in excellent anti-allergic, anti-itch, and skin-roughening effects. After preparing the composition into a soothing and anti-itch cream, tests showed that it significantly reduced the a* value and lactic acid stinging score of sensitive skin. Doctor evaluation methods further confirmed its significant improvement effects on burning, erythema, swelling, peeling, stinging, and itching of sensitive skin, while also showing a significant effect on improving rough skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a composition for relieving allergies and itching and improving rough skin, as well as its preparation method and application. Background Technology

[0002] Sensitive skin is generally considered to be caused by the interaction of internal and external factors, leading to impaired skin barrier function, increased transdermal moisture loss, and easier penetration of external irritants. This results in enhanced sensory nerve signal transmission, a lowered tolerance threshold, and an overreaction to even mild external stimuli. It also activates the skin's immune response, increases vascular reactivity, causing vasodilation, inflammatory cell infiltration, and symptoms such as redness, swelling, telangiectasia, tightness, burning, itching, and other skin discomfort. These symptoms can severely impact quality of life. Fragrances, preservatives, and surfactants added to cosmetics are common skin allergens; therefore, research on sensitive skin has become a hot topic in the cosmetics industry. Summary of the Invention

[0003] In view of the shortcomings of the prior art, the purpose of this invention is to provide a composition for relieving allergies and itching and improving rough skin, as well as its preparation method and application.

[0004] The objective of this invention is achieved through the following technical solution:

[0005] In a first aspect, the present invention provides a composition for relieving allergies and itching and improving rough skin, comprising the following active ingredients: hydroxyascorbic acid, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate.

[0006] Preferably, the raw materials are composed of the following ingredients in the following weight ratios: hydroxyascorbic acid glycoside / centella asiatica extract, water / butanediol / pepper leaf / root / stem extract, lecithin / aescin / β-sitosterol, allantoin, and sodium hyaluronate in the weight ratio of 0.1-0.3:0.05-0.4:0.1-0.5:0.2-0.5:0.001-0.01.

[0007] Secondly, the present invention provides the application of an anti-allergic, antipruritic, and skin-roughening composition in the preparation of skin care products, wherein the dosage form of the skin care products includes any one of creams, lotions, liquids, serums, masks, gels, base makeup, sprays, and facial cleansers.

[0008] Thirdly, the present invention provides a soothing and antipruritic cream, comprising the aforementioned anti-allergic, antipruritic, and skin-roughening composition, and further comprising emollients, moisturizers, emulsifiers, co-emulsifiers, antioxidants, chelating agents, thickeners, fragrances, and water.

[0009] Preferably, the moisturizer is selected from at least one of glycerin, 1,3-propanediol, panthenol, and 1,2-hexanediol.

[0010] Preferably, the emollient is selected from at least one of caprylic / capric triglyceride, shea butter, dimethicone, squalane, and jojoba seed oil.

[0011] Preferably, the emulsifier is selected from at least one of arachidonic acid / behenol / arachidonic acid glucoside and cetearyl alcohol / cetearyl glucoside;

[0012] The emulsifier is selected from cetearyl alcohol.

[0013] Preferably, the thickener is selected from at least one of ammonium acryloyldimethyl taurate / VP copolymer and xanthan gum;

[0014] The antioxidant is selected from at least one of p-hydroxyacetophenone and tocopherol / sunflower seed oil;

[0015] The chelating agent is selected from disodium EDTA;

[0016] The fragrance is selected from bergamot fruit oil / cedarwood oil.

[0017] Preferably, the soothing and antipruritic cream comprises the following ingredients in parts by weight: 0.1-0.3 parts of asiaticoside / centella asiatica extract, 0.05-0.4 parts of water / butylene glycol / pepper leaf / root / stem extract, 0.1-0.5 parts of lecithin / aescin / β-sitosterol, 0.2-0.5 parts of allantoin, 0.001-0.01 parts of sodium hyaluronate, 5-10 parts of glycerin, 2-6 parts of 1,3-propanediol, 0.5-1 part of panthenol, 0.3-0.6 parts of 1,2-hexanediol, 5-10 parts of caprylic / capric triglycerides, 5-10 parts of shea butter, and poly… 1-5 parts dimethylsiloxane, 1-3 parts squalane, 0.1-0.3 parts jobaba seed oil, 1-3 parts arachidonic acid / behenol / arachidonic acid glucoside, 1-3 parts cetearyl alcohol / cetearyl glucoside, 3-6 parts cetearyl alcohol, 0.1-0.5 parts ammonium acryloyl dimethyl taurate / VP copolymer, 0.01-0.1 parts xanthan gum, 0.2-0.5 parts p-hydroxyacetophenone, 0.02-0.05 parts tocopherol / sunflower seed oil, 0.02-0.08 parts disodium EDTA, 0.1-0.3 parts bergamot fruit oil / cedarwood oil, water to a total of 100 parts.

[0018] Fourthly, the present invention provides a method for preparing the aforementioned soothing and antipruritic cream, comprising the following steps:

[0019] The anti-allergic, anti-itch, and skin-roughening composition is weighed together with moisturizers, emollients, emulsifiers, co-emulsifiers, thickeners, chelating agents, antioxidants, and fragrances in the specified weight proportions, then added to water and stirred until homogeneous to obtain the soothing and anti-itch cream.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] This invention utilizes a combination of active ingredients including asiaticoside, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate, formulated in specific proportions to achieve excellent anti-allergic, antipruritic, and skin-roughening effects through the synergistic interaction of these components. When this composition was formulated into a soothing and antipruritic cream, testing revealed a significant reduction in the a* value of the red zone of sensitive skin (a reduction rate of over 10% after 28 days of use compared to before use) and the lactic acid stinging score (a reduction rate of over 40% after 28 days of use compared to before use). Furthermore, physician evaluation methods confirmed its significant improvement effects on burning, erythema, swelling, peeling, stinging, and itching of sensitive skin (improvement rate reached 100%). Testing also showed a significant increase in the skin roughness (SEr) value (an increase rate of over 32% after 28 days of use compared to before use). Detailed Implementation

[0022] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0023] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0024] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0025] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0026] The following embodiments provide a composition for relieving allergies, itching, and improving rough skin, comprising the following raw materials in the following weight ratios: asiaticoside / centella asiatica extract, water / butylene glycol / pepper leaf / root / stem extract, lecithin / aescin / β-sitosterol, allantoin, and sodium hyaluronate in a weight ratio of 0.1-0.3:0.05-0.4:0.1-0.5:0.2-0.5:0.001-0.01. The active ingredients in this composition are asiaticoside, centella asiatica extract, pepper kava extract, aescin, allantoin, and sodium hyaluronate.

[0027] In one specific embodiment, the asiaticoside / centella asiatica extract is derived from commercial asiaticoside 90%, and its components are asiaticoside and centella asiatica extract.

[0028] In one specific embodiment, the water / butanediol / pepper methystucum leaf / root / stem extract is derived from the commercial AXIAFLUID KAVA EXTRACT UP (manufactured by AXIALYS INNOVATIONS), and its components are: water, butanediol, and pepper methystucum leaf / root / stem extract.

[0029] In one specific embodiment, the lecithin / aescin / β-sitosterol is derived from the commercial ESCIN B-SITOSTEROL PHYTOSOME (manufactured by Givaudan Fragrance & Flavor (Shanghai) Co., Ltd.), and its components are: lecithin, aescin, and β-sitosterol.

[0030] The following embodiments also provide a soothing and antipruritic cream, comprising the aforementioned anti-allergic, antipruritic, and skin-roughening composition, and further comprising a moisturizer, emollient, emulsifier, co-emulsifier, thickener, antioxidant, chelating agent, fragrance, and water.

[0031] In one specific embodiment, the soothing and antipruritic cream specifically comprises the following ingredients in parts by weight: 0.1-0.3 parts of asiaticoside / centella asiatica extract, 0.05-0.4 parts of water / butylene glycol / pepper leaf / root / stem extract, 0.1-0.5 parts of lecithin / aescin / β-sitosterol, 0.2-0.5 parts of allantoin, 0.001-0.01 parts of sodium hyaluronate, 5-10 parts of glycerin, 2-6 parts of 1,3-propanediol, 0.5-1 part of panthenol, 0.3-0.6 parts of 1,2-hexanediol, 5-10 parts of caprylic / capric triglycerides, and 5-1 parts of shea butter. 0 parts, polydimethylsiloxane 1-5 parts, squalane 1-3 parts, jobaba seed oil 0.1-0.3 parts, arachidonic acid / behenol / arachidonic acid glucoside 1-3 parts, cetearyl alcohol / cetearyl glucoside 1-3 parts, cetearyl alcohol 3-6 parts, ammonium acryloyl dimethyl taurate / VP copolymer 0.1-0.5 parts, xanthan gum 0.01-0.1 parts, p-hydroxyacetophenone 0.2-0.5 parts, tocopherol / sunflower seed oil 0.02-0.05 parts, disodium EDTA 0.02-0.08 parts, bergamot fruit oil / cedarwood oil 0.1-0.3 parts, water to 100 parts.

[0032] In the following examples, all the raw materials used, such as moisturizers, emulsifiers, co-emulsifiers, thickeners, chelating agents, antioxidants, skin conditioning agents, and fragrances, are commercially available.

[0033] The preparation of the soothing and anti-itch cream described below can be carried out using conventional methods, and this invention does not impose any particular limitations.

[0034] Example 1

[0035] This embodiment provides a soothing and anti-itch cream, comprising a composition for relieving allergies, itching, and improving rough skin, a moisturizer, a skin conditioner, an emulsifier, an emulsion stabilizer, an antioxidant, a thickener, a fragrance, a pH adjuster, and water. The composition for relieving allergies, itching, and improving rough skin includes the following components: hydroxyascorbic acid, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate. The composition and weight ratio of each ingredient (total weight parts: 100 parts) are shown in Table 1. The specific steps for preparing the soothing and anti-itch cream are as follows:

[0036] 1) After cleaning and disinfecting the emulsifying pot, add appropriate amounts of water, glycerin, panthenol, disodium EDTA, and allantoin to the emulsifying pot at room temperature and stir well.

[0037] 2) Mix 1,3-propanediol, xanthan gum, and sodium hyaluronate, disperse them evenly, and add them to the emulsification pot treated in step 1) at room temperature. Then heat to 78-80℃ and stir for 30 minutes until dissolved evenly to obtain mixture A.

[0038] 3) Add caprylic / capric triglycerides, Butyrospermum Parkii fruit oil, cetearyl alcohol, cetearyl alcohol / cetearyl glucoside, arachidonic acid / behenol / arachidonic acid glucoside, squalane, and jojoba seed oil to the oil phase pot and heat to 78-80°C. Stir for 15 minutes until well mixed. If it cannot be dissolved, heat to 85°C to dissolve, then cool to 75-80°C and stir until well mixed.

[0039] 4) Add polydimethylsiloxane and tocopherol / helianthus annuus seed oil to the oil phase pot after step 3), stir and dissolve evenly to obtain mixture B;

[0040] 5) Pump the mixture B in the oil phase pot into the emulsification pot where the temperature of the mixture A is maintained at 80°C, homogenize at 2500 rpm for 3 minutes, stir for 15 minutes, vacuum at -0.03 MPa, and emulsify evenly.

[0041] 6) Add the ammonium acryloyl dimethyl taurate / VP copolymer to the emulsifying pot after step 5), homogenize at 2500 rpm for 1-2 minutes, stir for 10 minutes, and emulsify under vacuum of -0.03 MPa until uniform.

[0042] 7) Disperse lecithin / aescin / β-sitosterol in an appropriate amount of water, then add it to the emulsifying pot treated in step 6), stir for 15 minutes, vacuum -0.03MPa, and emulsify evenly;

[0043] 8) Cool the emulsifying pot after step 7) to 65°C, then add a mixed solution of p-hydroxyacetophenone and 1,2-hexanediol (heat to dissolve), stir for 10 minutes, vacuum -0.03MPa, and stir until homogeneous;

[0044] 9) Cool the emulsifying pot after step 8) to 40-45℃, then add asiaticoside / centella asiatica extract (dissolved in an appropriate amount of water before adding), bergamot fruit oil / cedarwood oil, water / butanediol / tremella fuciformis polysaccharide, and water / butanediol / piper methystucum leaf / root / stem extract in sequence. Stir for 15 minutes under vacuum at -0.03MPa until homogeneous.

[0045] 10) After stirring, vacuum at -0.07MPa, cool to 38℃ and defoam, filter out of the pot to obtain the soothing cream.

[0046] Example 2

[0047] This embodiment provides a soothing and anti-itch cream, comprising a composition for relieving allergies, itching, and improving rough skin, a moisturizer, a skin conditioner, an emulsifier, an emulsion stabilizer, an antioxidant, a thickener, a fragrance, a pH adjuster, and water. The composition for relieving allergies, itching, and improving rough skin includes the following components: asiaticoside, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate. The composition and weight ratio of each ingredient (total weight parts = 100 parts) are shown in Table 1. The preparation steps of the soothing and anti-itch cream are the same as in Example 1.

[0048] Example 3

[0049] This embodiment provides a soothing and anti-itch cream, comprising a composition for relieving allergies, itching, and improving rough skin, a moisturizer, a skin conditioner, an emulsifier, an emulsion stabilizer, an antioxidant, a thickener, a fragrance, a pH adjuster, and water. The composition for relieving allergies, itching, and improving rough skin includes the following components: asiaticoside, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate. The composition and weight ratio of each ingredient (total weight parts = 100 parts) are shown in Table 1. The preparation steps of the soothing and anti-itch cream are the same as in Example 1.

[0050] Example 4

[0051] This embodiment provides a soothing and anti-itch cream, comprising a composition for relieving allergies, itching, and improving rough skin, a moisturizer, a skin conditioner, an emulsifier, an emulsion stabilizer, an antioxidant, a thickener, a fragrance, a pH adjuster, and water. The composition for relieving allergies, itching, and improving rough skin includes the following components: asiaticoside, centella asiatica extract, kava extract, aesculin, allantoin, and sodium hyaluronate. The composition and weight ratio of each ingredient (total weight parts = 100 parts) are shown in Table 1. The preparation steps of the soothing and anti-itch cream are the same as in Example 1.

[0052] Table 1

[0053]

[0054]

[0055] Comparative Example 1

[0056] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its raw materials (total weight parts of 100 parts) are shown in Table 2. Compared with Example 1, the only difference is that: hydroxyascorbic acid glycoside / centella asiatica extract is not added, and the weight parts of water / butylene glycol / piper methystucum leaf / root / stem extract are 0.25 parts. The preparation steps of the soothing and antipruritic cream are the same as in Example 1.

[0057] Comparative Example 2

[0058] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its ingredients (total weight parts of 100 parts) are shown in Table 2. Compared with Example 1, the only difference is that water / butylene glycol / piper methemystucum leaf / root / stem extract is not added, and the weight parts of lecithin / aescin / β-sitosterol are 0.2 parts. The preparation steps of the soothing and antipruritic cream are the same as those in Example 1.

[0059] Comparative Example 3

[0060] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its raw materials (total weight parts of 100 parts) are shown in Table 2. Compared with Example 1, the only difference is that lecithin / aescin / β-sitosterol are not added, and the weight parts of asiaticoside / Centella asiatica extract are 0.25 parts. The preparation steps of the soothing and antipruritic cream are the same as those in Example 1.

[0061] Comparative Example 4

[0062] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 2. Compared with Example 1, the only difference is that allantoin is not added. The preparation steps of the soothing and antipruritic cream are the same as those of Example 1.

[0063] Comparative Example 5

[0064] This comparative example provides a soothing and anti-itch cream, the composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared with Example 1, the only difference is that sodium hyaluronate is not added. The preparation steps of the soothing and anti-itch cream are the same as those in Example 1.

[0065] Comparative Example 6

[0066] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its raw materials (total weight parts of 100 parts) are shown in Table 2. Compared with Example 2, the only difference is that the weight parts of lecithin / aescin / β-sitosterol are 0.1 parts, and the weight parts of water / butylene glycol / piper methystium leaf / root / stem extract are 0.6 parts. The preparation steps of the soothing and antipruritic cream are the same as those in Example 1.

[0067] Comparative Example 7

[0068] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its raw materials (total weight parts of 100 parts) are shown in Table 2. Compared with Example 3, the only difference is that the weight parts of asiaticoside / centella asiatica extract are 0.5 parts, and the weight parts of lecithin / aescin / β-sitosterol are 0.3 parts. The preparation steps of the soothing and antipruritic cream are the same as those in Example 1.

[0069] Comparative Example 8

[0070] This comparative example provides a soothing and antipruritic cream, the composition and weight ratio of its raw materials (total weight parts of 100 parts) are shown in Table 2. Compared with Example 3, the only difference is that the weight parts of asiaticoside / centella asiatica extract are 0.1 parts, and the weight parts of lecithin / aescin / β-sitosterol are 0.7 parts. The preparation steps of the soothing and antipruritic cream are the same as those in Example 1.

[0071] Table 2

[0072]

[0073]

[0074] Efficacy verification:

[0075] The soothing and antipruritic creams prepared in Examples 1-4 and Comparative Examples 1-8 were used as test samples for efficacy testing.

[0076] 1) Test subjects

[0077] Subjects aged 20-55 years with sensitive skin (stinging score ≥3 points) as determined by a lactic acid stinging test were included. Subjects were then grouped according to the tested product, with 25-35 people in each group.

[0078] 2) How to use

[0079] After cleansing, apply an appropriate amount of the test product evenly to the face and massage until absorbed. Use twice daily, once in the morning and once in the evening. During the testing period, participants should not change their other lifestyle, dietary, or skincare habits, and should use the provided test product entirely instead of their own face cream.

[0080] 3) Testing methods

[0081] Tests were conducted on each subject before using the test product (baseline values) and 28 days after use. The procedure for each test was as follows: the subject cleansed their face with the specified facial cleanser sample, then sat quietly for 30 minutes in a laboratory at a temperature of 21±1℃ and a humidity of 50±10% RH, before the specific test was performed.

[0082] Facial imaging data was acquired using VISIA-CR images to obtain the a* value of the skin red area (the smaller the value, the less redness of the skin).

[0083] The skin roughness SEr value of the face was measured using the Visioscan VC20plus skin surface texture analysis system. The smaller the skin roughness SEr value, the rougher the skin.

[0084] The lactic acid stinging method was used to test the nasolabial folds. The specific steps were as follows: 50 μL of 5% lactic acid aqueous solution and 50 μL of distilled water (control group) were dropped onto a 0.8 cm diameter medical filter and applied to both sides of the nasolabial folds. The subjects were asked about their stinging sensation at 0.5 min, 2.5 min, 5 min, and 8 min, and scored using a 4-point scale (0 points for no stinging sensation, 1 point for mild stinging sensation, 2 points for moderate stinging sensation, and 3 points for severe stinging sensation). The subjects' scores were recorded. The lactic acid stinging score = the sum of the scores at the four time points on the lactic acid side + the sum of the scores at the four time points on the distilled water side. The lower the lactic acid stinging score, the stronger the skin's tolerance to lactic acid stinging.

[0085] In addition, a doctor assessment (four-point scale) method was used, in which doctors scored the subjects' facial burning, erythema, swelling, peeling, stinging and itching. Doctor assessment - safety scoring details: 0 points = none, 1 point = mild, 2 points = moderate, 3 points = severe.

[0086] Burning: 0 points, no burning sensation; 1 point, occasionally felt; 2 points, noticeable burning sensation, but tolerable; 3 points, noticeable burning sensation, requiring cool water for relief.

[0087] Erythema: 0 points, no erythema; 1 point, slightly red; 2 points, pale red; 3 points, very red;

[0088] Redness and swelling: 0 points, no redness and swelling; 1 point, slight swelling; 2 points, obvious redness and swelling; 3 points, very swollen;

[0089] Desquamation: 0 points, no desquamation; 1 point, can only be seen with careful observation; 2 points, scales can be seen immediately; 3 points, desquamation is very obvious;

[0090] Stinging: 0 points, no stinging sensation; 1 point, occasionally felt; 2 points, noticeable stinging, but tolerable; 3 points, very noticeable stinging.

[0091] Itching: 0 points, no itching sensation; 1 point, slight itching, can avoid scratching; 2 points, obvious itching, can't help but scratch; 3 points, severe itching, affects sleep and work, causes emotional distress.

[0092] 4) Test Results

[0093] 4.1 The soothing and antipruritic creams prepared in Examples 1-4 and Comparative Examples 1-8 were used as test samples. The average transepidermal water loss rate of the skin in each group of subjects is shown in Table 3. The reduction rate was calculated according to the following formula:

[0094] Reduction rate (%) = (Test value before use - Test value after use) / Test value before use * 100%

[0095] Table 3

[0096]

[0097]

[0098] As can be seen from the results in Table 3, the soothing and antipruritic creams prepared in Examples 1-4 have a very good effect on reducing the a* value of the skin red area. Compared with before use, the a* value of the skin red area was reduced by more than 10% after 28 days of use.

[0099] The results of comparing Example 1 with those of Comparative Examples 1-5 show that the absence of the addition of asiaticoside / centella asiatica extract, water / butanediol / piper methystucum leaf / root / stem extract, lecithin / aescin / β-sitosterol, allantoin or sodium hyaluronate resulted in a significantly lower reduction rate of a* value in the skin red zone compared to Example 1.

[0100] Further comparison of the results of Example 2 and Comparative Example 6, and the results of Example 3 and Comparative Examples 7-8, shows that changing the weight ratio of asiaticoside / Centella asiatica extract, water / butanediol / piper methemysticum leaf / root / stem extract, lecithin / aescin / β-sitosterol, and allantoin also resulted in a significantly lower a* value reduction rate in the skin red area compared to Examples 2 and 3.

[0101] 4.2 The soothing and antipruritic creams prepared in Examples 1-4 and Comparative Examples 1-5 were used as test samples. The average improvement rate of skin roughness SEr value measured in each group of subjects is shown in Table 4. The improvement rate was calculated according to the following formula:

[0102] Improvement rate (%) = (Test value after use - Test value before use) / Test value before use * 100%

[0103] Table 4

[0104] Test sample Skin roughness (SEr) improvement rate (%) Example 1 32.62％ Example 2 39.48％ Example 3 36.64％ Example 4 40.37％ Comparative Example 1 28.46％ Comparative Example 2 22.05％ Comparative Example 3 25.73％ Comparative Example 4 13.64％ Comparative Example 5 19.88％

[0105] As can be seen from the results in Table 4, the soothing and antipruritic creams prepared in Examples 1-4 have a very good effect on improving skin roughness. Compared with before use, the skin roughness SEr value improved by more than 32% after 28 days of use.

[0106] The results of comparing Example 1 with those of Comparative Examples 1-5 show that the absence of asiaticoside / centella asiatica extract, water / butylene glycol / piper methystucum leaf / root / stem extract, lecithin / aescin / β-sitosterol, allantoin or sodium hyaluronate resulted in a significantly lower rate of improvement in skin roughness SEr value compared to Example 1.

[0107] 4.3 The soothing and antipruritic creams prepared in Examples 1-4 and Comparative Examples 1-8 were used as test samples. The reduction rate (average) of lactic acid stinging score values ​​measured in each group of subjects is shown in Table 5. The reduction rate of lactic acid stinging score values ​​was calculated according to the following formula:

[0108] Lactic acid stinging score reduction rate (%) = (Score before use - Score after use) / Score before use * 100%

[0109] Table 5

[0110] Test sample Reduction rate of lactic acid stinging score (%) Example 1 45.63％ Example 2 40.68％ Example 3 42.42％ Example 4 50.38％ Comparative Example 1 29.74％ Comparative Example 2 23.48％ Comparative Example 3 27.85％ Comparative Example 4 35.91％ Comparative Example 5 38.66％ Comparative Example 6 21.57％ Comparative Example 7 30.49％ Comparative Example 8 25.20％

[0111] As can be seen from the results in Table 5, the soothing and antipruritic creams prepared in Examples 1-4 have a very good effect in reducing lactic acid irritation. Compared with before use, the lactic acid stinging score was reduced by more than 40% after 28 days of use.

[0112] The results of comparing Example 1 with those of Comparative Examples 1-5 show that the absence of asiaticoside / centella asiatica extract, water / butanediol / piper methystucum leaf / root / stem extract, lecithin / aescin / β-sitosterol, allantoin or sodium hyaluronate resulted in a significantly lower reduction rate of lactic acid stinging score compared to Example 1.

[0113] Further comparison of the results of Example 2 and Comparative Example 6, and the results of Example 3 and Comparative Examples 7-8, shows that changing the weight ratio of asiaticoside / Centella asiatica extract, water / butanediol / piper methemysticum leaf / root / stem extract, lecithin / aescin / β-sitosterol, and allantoin also resulted in a significantly lower reduction rate of lactic acid stinging score compared to Examples 2 and 3.

[0114] 4.4 The soothing and antipruritic creams prepared in Examples 1-4 were used as test samples. Subjects in each group underwent physician evaluation before and 28 days after use. The improvement rates for each evaluation item are shown in Table 6. The improvement rate was calculated as follows:

[0115] Improvement rate = (Evaluation score before use - Evaluation score after use) / Evaluation score before use * 100%

[0116] Table 6

[0117]

[0118] As can be seen from the results in Table 6, the soothing and antipruritic creams prepared in Examples 1-4 have very good effects in improving skin burning, erythema, swelling, peeling, stinging and itching. Compared with before use, the improvement rate after use reached 100%.

[0119] In summary, this invention, by combining raw materials containing specific active ingredients such as asiaticoside, centella asiatica extract, aescin, kava extract, allantoin, and sodium hyaluronate, and selecting a specific weight ratio range, allows the components to work synergistically. This significantly reduces the a* value and lactic acid stinging score of sensitive skin. Furthermore, physician evaluation methods have confirmed its significant improvement effects on burning, erythema, swelling, peeling, stinging, and itching of sensitive skin, while also demonstrating a significant effect on improving skin roughness. Therefore, this invention proves that the composition of this invention has excellent anti-allergic, antipruritic, and skin-roughening effects.

[0120] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A composition for relieving allergies, stopping itching, and improving rough skin, characterized in that, The composition comprises the following raw materials in the following weight ratios: hydroxyl asiaticoside / centella asiatica extract, water / butylene glycol / kava leaf / root / stem extract, lecithin / escolin / beta-sitosterol, allantoin, and sodium hyaluronate in a weight ratio of 0.1-0.3:0.05-0.4:0.1-0.5:0.2-0.5:0.001-0.01; The hydroxyl asiaticoside / centella asiatica extract has a trade name of hydroxyl asiaticoside 90%; The water / butylene glycol / kava leaf / root / stem extract has a trade name of AXIAFLUID KAVA EXTRACT UP; The lecithin / escolin / beta-sitosterol has a trade name of ESCIN B-SITOSTEROL PHYTOSOME.

2. Use of the antiallergic and skin-roughness-improving composition according to claim 1 in the production of a skin care product, characterized in that, The dosage form of the skin care product includes any one of cream, emulsion, water, essence, mask, jelly, foundation, spray, and cleansing product.

3. A soothing itch relief cream, characterized in that, The composition for anti-allergic itching and improving skin roughness according to claim 1, further comprises emollients, humectants, emulsifiers, co-emulsifiers, antioxidants, chelating agents, thickening agents, fragrances, and water.

4. The soothing itch relief cream of claim 3, wherein, The humectants are selected from at least one of glycerin, 1,3-propanediol, panthenol, and 1,2-hexanediol.

5. The soothing itch relief cream of claim 3, wherein, The emollients are selected from at least one of caprylic / capric triglyceride, shea butter, dimethicone, squalane, and jojoba seed oil.

6. The soothing itch relief cream of claim 3, wherein, The emulsifiers are selected from at least one of arachidyl / behrenyl / arachidyl glucoside and cetearyl alcohol / cetearyl glucoside; The co-emulsifiers are selected from cetearyl alcohol.

7. The soothing itch relief cream of claim 3, wherein, The thickening agents are selected from at least one of acryloyldimethyltaurine ammonium / VP copolymer and xanthan gum; The antioxidants are selected from at least one of p-hydroxyacetophenone and tocopherol / sunflower seed oil; The chelating agents are selected from disodium EDTA; The fragrances are selected from bergamot fruit oil / cedarwood oil.

8. The soothing itch relief cream of claim 3, wherein, The soothing itching cream comprises the following raw materials in the following amounts: hydroxyl asiaticoside / centella asiatica extract 0.1-0.3 parts, water / butylene glycol / kava leaf / root / stem extract 0.05-0.4, lecithin / escolin / beta-sitosterol 0.1-0.5 parts, allantoin 0.2-0.5 parts, sodium hyaluronate 0.001-0.01 parts, glycerin 5-10 parts, 1,3-propanediol 2-6 parts, panthenol 0.5-1 part, 1,2-hexanediol 0.3-0.6 parts, caprylic / capric triglyceride 5-10 parts, shea butter 5-10 parts, dimethicone 1-5 parts, squalane 1-3 parts, jojoba seed oil 0.1-0.3 parts, arachidyl / behrenyl / arachidyl glucoside 1-3 parts, cetearyl alcohol / cetearyl glucoside 1-3 parts, cetearyl alcohol 3-6 parts, acryloyldimethyltaurine ammonium / VP copolymer 0.1-0.5 parts, xanthan gum 0.01-0.1 parts, p-hydroxyacetophenone 0.2-0.5 parts, tocopherol / sunflower seed oil 0.02-0.05 parts, disodium EDTA 0.02-0.08 parts, bergamot fruit oil / cedarwood oil 0.1-0.3 parts, and water to 100 parts.

9. A process for the preparation of the soothing anti-itch cream according to any one of claims 3-8, characterized in that, It comprises the following steps: The soothing and antipruritic composition for rough skin is prepared by taking the soothing and antipruritic composition, moisturizer, emollient, emulsifier, co-emulsifier, thickening agent, chelating agent, antioxidant and fragrance by weight, adding them into water and stirring uniformly.

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