A radionuclide dispenser, dispensing system and method of dispensing

Abstract

A radionuclide dispenser, a dispensing system and a dispensing method, the radionuclide dispenser comprising a base, a stand arranged on one side of the base, a first limit switch and a second limit switch connected to the stand, a liquid injection and distribution pipe driving assembly connected to the stand, a sliding table in transmission connection with the liquid injection and distribution pipe driving assembly, a radionuclide bottle arranged on the base, a first pressurizing pipe and a liquid injection and distribution pipe in communication with the radionuclide bottle, and the liquid injection and distribution pipe being fixed on the sliding table and sliding up and down with the sliding table. The radionuclide dispenser, the dispensing system and the dispensing method provided by the application have high automation degree, simple structure, realize automatic quantitative and on-demand dispensing of radionuclides, and have high dispensing precision.

Description

Technical Field

[0001] This invention relates to the field of medical experimental equipment technology, specifically to a radionuclide dispenser, dispensing system, and dispensing method. Background Technology

[0002] In nuclear medicine technologies, such as PET (positron emission tomography) imaging, radiolabeled drugs are frequently used. With the development of technology, PET can detect more and more types of tumors, and the types of radiopharmaceuticals that need to be synthesized are constantly being innovated and developed. The demand for radionuclides and the demand for quantitative labeling are constantly increasing.

[0003] Typically, after radionuclides (also known as target water) are produced in medical cyclotrons, they need to be dispensed into different distribution terminals, such as hot chambers, collection bottles, synthesis modules, or synthesizers. Existing medical cyclotrons can produce several Curie (Ci) doses of radionuclides in a single operation. However, these radionuclides are radioactive and cannot be directly contacted by humans. Furthermore, the target water delivered from the cyclotron is only 1.5–3 ml in volume, a very small quantity, and needs to be directly transferred to the distribution terminals. Therefore, distributing the radionuclides produced in a single cyclotron operation in batches to produce different radiopharmaceuticals becomes a significant challenge. Summary of the Invention

[0004] To address the problem of on-demand distribution of radionuclides in existing technologies, this invention provides a radionuclide dispenser, a distribution system, and a distribution method to improve the distribution of radionuclides.

[0005] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is as follows: A radionuclide dispenser includes a base and a stand disposed on one side of the base; a first limit switch and a second limit switch connected to the stand; a liquid injection / dispensing pipe drive assembly connected to the stand; a slide table pulverizedly connected to the liquid injection / dispensing pipe drive assembly; a radionuclide bottle disposed on the base; a first pressurization pipe and a liquid injection / dispensing pipe connected to the radionuclide bottle; the liquid injection / dispensing pipe is fixed to the slide table and slides up and down with the slide table.

[0006] Preferably, the liquid injection and distribution pipe drive assembly includes a drive motor and a lead screw connected to the drive motor.

[0007] Preferably, the liquid injection and distribution tube passes through the slide.

[0008] Preferably, the slide table includes a slider and a positioning block connected to each other; the slider is connected to the liquid injection and dispensing pipe drive assembly; and the liquid injection and dispensing pipe passes through the positioning block.

[0009] Preferably, the positioning block includes a first positioning block and a second positioning block that are separately configured, and the liquid injection tube is clamped between the first positioning block and the second positioning block.

[0010] Preferably, the first positioning block is provided with a positioning groove, and the slider is fixed in the positioning groove.

[0011] Preferably, the right side wall of the first positioning block is recessed inward to form a first fixing groove, and the left side wall of the second positioning block is provided with a second fixing groove corresponding to the first fixing groove. The second fixing groove and the first fixing groove form a second through hole, and the liquid injection pipe is clamped in the second through hole.

[0012] Another object of the present invention is to provide a radionuclide distribution system, comprising a radionuclide dispenser; a first reversing valve connected to the radionuclide dispenser via a first pressurization tube; and a system connected to the first reversing valve. The first nitrogen end and the atmospheric end; connected to the first multi-way valve of the radionuclide distributor via the liquid injection and distribution pipe; connected to The target water input pipeline of the first multi-way valve; connected to at least one distribution terminal of the first multi-way valve via a branch pipeline; and electrically connected to the PLC controller of the first multi-way valve, the first reversing valve, and the radionuclide distributor.

[0013] Preferably, it further includes a dilution main pipeline, a second multi-way valve connected to the dilution main pipeline, a dilution bottle connected to the second multi-way valve via a dilution water pipeline, a syringe connected to the second multi-way valve via a syringe pipeline, and a dilution water slide connected to the syringe.

[0014] Another object of the present invention is to provide a method for distributing radionuclides, comprising the following steps: Step S1: Introduce a radioactive nuclide into the radioactive nuclide dispenser; Step S2: The user selects the first distribution terminal for the radionuclide and inputs the first distribution data. The PLC controller calculates the depth of the liquid injection tube inserted into the radionuclide bottle based on the user input data and controls the slide of the radionuclide dispenser to move. The slide drives the liquid injection tube to be inserted into the radionuclide bottle to a set depth below the liquid surface. Step S3: The PLC controller controls the first reversing valve to open, allowing nitrogen gas to be introduced into the upper part of the radionuclide bottle. Under the positive pressure of nitrogen gas, the radionuclide between the target water surface and the lower opening of the injection and distribution pipe will be transferred to the designated distribution terminal, completing the first distribution of the radionuclide. Step S4: The user selects the next distribution terminal for the radionuclide and enters the distribution amount. Repeat step S3 to complete the next distribution of the radionuclide, and so on, until the user stops inputting distribution information.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The radionuclide dispenser provided by this invention has a simple structure, a high degree of automation, and realizes automatic quantitative on-demand dispensing of radionuclides with high dispensing accuracy.

[0016] 2. The automatic dispensing system provided by the present invention uses a PLC controller to control a slide table to move the liquid injection and dispensing pipe to a designated position below the surface of the dilution target water. In conjunction with the pressurization pipe, nitrogen gas is introduced to push the dilution target water into different dispensing terminals, thereby completing the automatic dispensing of radionuclides, greatly improving the dispensing accuracy, and making the operation simple.

[0017] 3. The radionuclide allocation method provided by this invention has each allocation step working in concert, which greatly improves the allocation accuracy and efficiency. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the radionuclide dispenser in Embodiment 1 of the present invention; Figure 2 This is an exploded structural diagram of the slide table in Embodiment 1 of the present invention; Figure 3 This is a three-dimensional structural diagram of the slider in Embodiment 1 of the present invention; Figure 4 This is a three-dimensional structural diagram of the first positioning block in Embodiment 1 of the present invention; Figure 5 This is a three-dimensional structural diagram of the second positioning block in Embodiment 1 of the present invention; Figure 6 This is a three-dimensional structural schematic diagram of the liquid injection and distribution pipe driving assembly in Embodiment 1 of the present invention; Figure 7 This is a three-dimensional structural diagram of the radionuclide bottle in Embodiment 1 of the present invention; Figure 8 This is a schematic diagram of the radionuclide distribution system in Embodiment 2 of the present invention; Figure 9 This is a schematic diagram of the electrical control principle of the radionuclide distribution system in Embodiment 2 of the present invention; Figure 10 This is a flowchart of the radionuclide allocation method in Embodiment 3 of the present invention.

[0019] In the diagram: Base 1; Stand 2; First limit switch 3; Second limit switch 4; Liquid injection / dispensing pipe drive assembly 5; Drive motor 51; Lead screw 52; Slide table 6; Slider 61; Groove 611; Second fixing hole 612; First through hole 613; First positioning block 62; Positioning groove 621; First shoulder 622; Second shoulder 623; First fixing hole 624; First fixing groove 625; Second positioning block 63; Second Fixed groove 631; third through hole 632; fourth fixed hole 633; ​​radionuclide bottle 7; bottle cap 71; bottle stopper 72; bottle body 73; first pressurization tube 8; liquid injection and dispensing tube 9; limiting frame 10; fixing frame 11; vertical frame 111; horizontal frame 112; support guide column 12; limiting pressure plate 13; protective cover 14; dispensing terminal 15; first reversing valve 16; first nitrogen end 17; atmospheric end 18; first multi-way valve 19; target water input pipeline 20; PLC controller 21; dilution main pipeline 22; second multi-way valve 23; dilution water pipeline 24; dilution bottle 25; syringe pipeline 26; syringe 27; dilution water slide 28; second pressurization tube 29; control valve 30; second nitrogen end 31; power supply 32; host computer 33; radionuclide dispenser 100. Detailed Implementation

[0020] To provide a clearer understanding of the technical features, objectives, and beneficial effects of the present invention, the technical solution of the present invention will now be described in detail with reference to the following specific embodiments, but this should not be construed as limiting the scope of implementation of the present invention.

[0021] It should be noted that the term "comprising" and any variations thereof in the specification, claims, and accompanying drawings of this invention are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or devices.

[0022] In this invention, the terms "upper," "lower," "inner," "outer," "top," and "bottom," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for the purpose of better describing the invention and its embodiments, and are not intended to limit the indicated devices, elements, or components to having a specific orientation, or to require them to be constructed and operated in a specific orientation. Furthermore, some of the aforementioned terms may have other meanings besides indicating orientation or positional relationship; for example, the term "upper" may in some cases indicate a dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in this invention according to the specific circumstances.

[0023] Furthermore, the terms "setup" and "connection" should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be an internal connection between two devices, components, or parts. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances. Example

[0024] This embodiment 1 provides a radionuclide dispenser 100, which is designed as an independent unit and can be easily placed inside the activity meter measuring well.

[0025] like Figure 1 As shown, the radionuclide dispenser 100 provided in this embodiment 1 can automatically dispense radionuclide according to different demand amounts. It includes a base 1, a stand 2 disposed on one side of the base 1; a first limit switch 3 and a second limit switch 4 connected to the stand 2, and a liquid injection and dispensing pipe drive assembly 5, a slide 6 connected to the liquid injection and dispensing pipe drive assembly 5; a radionuclide bottle 7 disposed on the base 1; and a first pressurization pipe 8 and a liquid injection and dispensing pipe 9 connected to the radionuclide bottle 7.

[0026] like Figure 1 As shown, the upright frame 2 extends vertically upward from one side of the base 1. The upright frame 2 can be separately installed from the base 1 and then assembled together; or the upright frame 2 and the base 1 can form an integral structure.

[0027] The first limit switch 3 and the second limit switch 4 are arranged parallel to each other on the support frame 2 along its length. The first limit switch 3 and the second limit switch 4 are electrically connected to the PLC controller 21 and limit the displacement of the slide table 6 according to the control signals from the PLC controller 21. The second limit switch 4 can be a mechanical limit switch, an electromagnetic limit switch, a photoelectric limit switch, or a hydraulic limit switch. Guan, etc.

[0028] In one possible implementation, the first limit switch 3 and the second limit switch 4 are fixed to the upright frame 2 by a limiting bracket 10. The limiting bracket 10 is a cantilever structure, approximately L-shaped, with one end fixed to the outer wall of the upright frame 2 by fasteners, and the other end used to connect the first limit switch 3 or the second limit switch 4. Of course, the fixing position and method of the first limit switch 3 or the second limit switch 4 can also be designed according to actual needs and are not limited to this method. For example, the first limit switch 3 or the second limit switch 4 can be directly fixed to the upright frame 2 by fasteners without the need for a dedicated limiting bracket 10.

[0029] like Figure 1 and Figure 6 As shown, the liquid injection and dispensing pipe drive assembly 5 is fixed on the upright frame 2, providing the power for the slide table 6 to slide up and down. The liquid injection and dispensing pipe drive assembly 5 includes a drive motor 51 and a lead screw 52 connected to the drive motor 51.

[0030] The drive motor 51 is preferably a stepper motor, which is electrically connected to the PLC controller 21. When the drive motor 51 receives the control signal from the PLC controller 21 and starts, it drives the lead screw 52 to rotate. The lead screw 52 drives the slide table 6 to move up and down. The up and down movement of the slide table 6 drives the liquid injection and distribution pipe 9 to move up and down.

[0031] In one possible implementation, such as Figure 1 As shown, the liquid injection and dispensing pipe drive assembly 5 is fixed to the inner wall of the upright frame 2 by a fixing bracket 11. Figure 6 As shown, the fixing frame 11 consists of a vertical frame 111 and horizontal frames 112 vertically connected to both ends of the vertical frame 111. The vertical frame 111 is fixed to the inner wall of the upright frame 2 by fasteners. The lead screw 52 is fixed between the two horizontal frames 112. Two supporting guide columns 12 are also provided between the two horizontal frames 112, and the slide table 6 is movably mounted on the supporting guide columns 12.

[0032] The slide 6 is restricted to slide up and down between the first limit switch 3 and the second limit switch 4, and the liquid injection pipe 9 is fixed on the slide 6 and slides up and down with the slide 6.

[0033] There are multiple ways to fix the liquid injection and dispensing pipe 9 to the slide table 6. As long as the slide table 6 can slide up and down along the lead screw 52, ​​the liquid injection and dispensing pipe 9 can slide up and down with the slide table 6.

[0034] For example, the slide 6 is an integral structure, with a first through hole that mates with the lead screw 52 and a second through hole through which the liquid injection and distribution pipe 9 passes. A liquid phase connector can be fitted onto the liquid injection and distribution pipe 9, and the liquid phase connector is threadedly connected to the slide 6 to achieve a tight fixation of the liquid injection and distribution pipe 9 on the slide 6.

[0035] For example, appendix Figure 2 As shown in Figure 6, the slide table 6 is a modular assembly structure. It includes a slider 61 and a positioning block that are connected to each other; the lead screw 52 passes through the slider 61, and the liquid injection and dispensing pipe 9 passes through and is fixed to the positioning block.

[0036] The positioning block can also be designed as an integral or modular assembly structure. In this embodiment 1, the positioning block includes a first positioning block 62 and a second positioning block 63 that are separately configured, and the liquid injection tube 9 is clamped between the first positioning block 62 and the second positioning block 63.

[0037] The slider 61 is provided with a first positioning space to accommodate the supporting guide post 12. The first positioning space can be a groove or a through hole. In this embodiment 1, as shown... Figure 3 As shown, the first positioning space is a groove 611 formed by the outer side of the slider 61 recessed inward. The groove 611 has a door-shaped cross-section and an arc-shaped inner side.

[0038] The slider 61 can be made of either plastic or metal.

[0039] like Figure 3 As shown, the slider 61 is also provided with the first through hole 613 on one side of the groove 611, and the lead screw 52 cooperates with the first through hole 613.

[0040] like Figure 4 As shown, the first positioning block 62 is provided with a positioning groove 621, and the slider 61 is fixed in the positioning groove 621 by fasteners. In one possible embodiment, the left side wall of the first positioning block 62 is positioned near its middle position. The positioning groove 621 is formed by a recess. The positioning groove 621 has an opening on the left side, with a first shoulder 622 on its upper side and a second shoulder 622 on its lower side. Second shoulder 623.

[0041] Both the first shoulder 622 and the second shoulder 623 are provided with a first fixing hole 624; the slider 61 is provided with a second fixing hole 612 corresponding to the first fixing hole 624, the slider 61 is partially disposed in the positioning groove 621, and the fastener passes through the first fixing hole 624 and the second fixing hole 612 in sequence to fasten the slider 61 to the first positioning block 62.

[0042] The right side wall of the first positioning block 62 is recessed inward to form a first fixing groove 625, and the left side wall of the second positioning block 63 is provided with a second fixing groove 631 corresponding to the first fixing groove 625. The second fixing groove 631 and the first fixing groove 625 form a second through hole, and the liquid injection pipe 9 is interference-fitted into the second through hole.

[0043] If the positioning block is an integral structure, the second through hole can be directly opened on the positioning block, and other fixing structures can be used to interfer fit the liquid injection pipe 9 into the second through hole.

[0044] As shown in the figure Figure 2 , Figure 4 and Figure 5 As shown, in one possible implementation, the first positioning block 62 is provided with a third fixing hole (not shown), and the second positioning block 63 is also provided with a fourth fixing hole 633 at a position corresponding to the third fixing hole. The fastener passes through both the third fixing hole and the fourth fixing hole 633, thereby forming a tight connection between the first positioning block 62 and the second positioning block 63, realizing an interference fit between the liquid injection pipe 9 and the second through hole, so that the liquid injection pipe 9 is tightly fixed in the slide table 6, and the liquid injection pipe 9 can move up and down with the slide table 6.

[0045] In one possible implementation, the third fixing hole is a threaded hole, and the fourth fixing hole 633 is a through hole.

[0046] The second positioning block 63 is also provided with a third through hole 632, through which the first pressurizing pipe 8 passes. The first pressurizing pipe 8 is clearance-fitted with the third through hole 632, and the first pressurizing pipe 8 does not move up and down with the slide table 6. The first pressurizing pipe 8 passing through the second positioning block 63 not only makes the pipe layout neat but also makes the nitrogen pressurization flow smoother, improving the distribution accuracy. Of course, depending on different design requirements, the first pressurizing pipe 8 can also be directly connected to the radionuclide bottle 7 without passing through the second positioning block 63.

[0047] The fasteners described in this embodiment 1 can be bolts, screws, or studs, etc.

[0048] like Figure 1As shown, a limit plate 13 is also fixed on the first positioning block 62. When the slide table 6 moves to the upper limit position, the limit plate 13 triggers the spring on the first limit switch 3 to disconnect the power supply to the drive motor 51, ensuring that the slide table 6 will not continue to rise; when the slide table 6 moves to the lower limit position, the limit plate 13 triggers the spring on the second limit switch 4 to disconnect the power supply to the drive motor 51, ensuring that the slide table 6 will not continue to fall.

[0049] like Figure 1 As shown, in one possible implementation, the radionuclide dispenser further includes a protective cover 14 fixed to the stand 2. The protective cover 14 is disposed around the drive motor 51 to prevent the circuit of the drive motor 51 from being exposed and to avoid safety hazards.

[0050] like Figure 7 As shown, the radionuclide bottle 7 includes a cap 71, a stopper 72, and a bottle body 73, used to collect and dispense radionuclides to be dispensed. The stopper 72 is disposed between the cap 71 and the bottle body 73 to prevent leakage of the target water.

[0051] The bottle cap 71 has two layers: an inner soft silicone cap and an outer hard plastic cap. The liquid injection tube 9 is inserted into the center of the radionuclide bottle 7 through a hole punched in the hard plastic cap, with the soft silicone cap covering the tube. The soft silicone cap encloses the liquid injection tube 9 to form a seal, making the target water protection more rigorous.

[0052] The bottle body 73 is a container with a pointed cone shape at the lower part of its inner cavity. The slide 6 returns to zero, meaning it has moved to its upper limit position. When the liquid is in place, the lower opening of the liquid injection and distribution tube 9 is located above the target water surface; during the distribution process, the liquid injection and distribution tube 9 moves downward according to the control signal of the PLC controller 21; during the last distribution, the liquid injection and distribution tube 9 contacts the pointed end of the bottle body 73, so that all the target water can be extracted during the distribution.

[0053] During the distribution of radionuclides, the PLC controller 21 controls the start of the drive motor 51, which drives the lead screw 52 to rotate. The slide table 6 moves up and down with the rotation of the lead screw 52. At this time, the liquid injection tube 9 fixed on the slide table 6 also moves up and down with the slide table 6 and is pulled out or inserted into the radionuclide bottle 7. The PLC controller 21 controls the insertion depth / position of the liquid injection tube 9. Different amounts of radionuclides are extracted according to the different insertion depths / positions and delivered to different distribution terminals 15, thus realizing the distribution of radionuclides with different required doses. Example

[0054] like Figure 8 As shown, this embodiment 2 provides a radionuclide distribution system for collecting radionuclides transmitted from a medical cyclotron and then automatically distributing them to different distribution terminals 15 according to different demand amounts.

[0055] The radionuclide distribution system includes a radionuclide distributor 100; a first reversing valve 16 connected to the radionuclide distributor 100 via a first pressurization pipe 8; a first nitrogen end 17 and an atmospheric end 18 connected to the first reversing valve 16; a first multi-way valve 19 connected to the radionuclide distributor 100 via a liquid injection and distribution pipe 9; a target water input pipe 20 connected to the first multi-way valve 19; at least one distribution terminal 15 connected to the first multi-way valve 19 via a branch pipe; and a PLC controller 21 electrically connected to the first multi-way valve 19, the first reversing valve 16, and the radionuclide distributor 100.

[0056] The first reversing valve 16 is any one of a three-way valve, a four-way valve, a five-way valve, and a six-way valve.

[0057] like Figure 9 As shown, the radioactive fluoride ion distribution system also includes a host computer 33, which communicates with the PLC controller 21 for inputting and displaying distribution data. The distribution data includes the total target water volume or total radioactivity transmitted by the host computer 33, and the target water volume for each distribution. The host computer can be a computer main control board, a computer terminal, or a mobile phone terminal, etc.

[0058] The PLC controller 21 can be a Shanghai Chenzhu PLC controller, used to control the connection, cut-off, and reversal of the first reversing valve 16, the first multi-way valve 19, the second multi-way valve 23, and the control valve 30; control the sliding of the radioactive fluoride ion distributor 100 and the dilution water slide 28; and calculate the up-and-down sliding distance of the dilution water slide 28 and the radioactive fluoride ion distributor 100 driving the liquid injection pipe 9 according to the distribution data input by the host computer 33.

[0059] The radioactive fluoride ion distribution system also includes a power source 32, which provides electrical energy to the radioactive fluoride ion distribution system.

[0060] During distribution, firstly, under the control of the PLC controller 21, the radionuclide transmitted from the cyclotron passes sequentially through the target water input pipeline 20, the first multi-way valve 19, and the liquid injection and distribution pipe 9 into the radionuclide bottle 7. Simultaneously, the PLC controller 21 controls the first reversing valve 16 to open, connecting the atmospheric end 18 with the radionuclide bottle 7 via the first pressurization pipe 8, and simultaneously venting air from the radionuclide bottle 7 during the radionuclide input process. Next, after the user sets the distribution amount, the radionuclide distributor 100 starts according to the control signal of the PLC controller 21 and drives the liquid injection and distribution pipe 9 to insert below the set depth of the target water in the radionuclide bottle 7. The PLC controller 21 then controls the first reversing valve 16 to open, introducing nitrogen gas into the upper part of the radionuclide bottle 7. Under the positive pressure of nitrogen gas, the radionuclide between the target water surface and the lower opening of the liquid injection and distribution pipe 9 will be transmitted to the set distribution terminal 15, completing the distribution of the radionuclide.

[0061] When the total volume of target water is relatively small, the distribution error is large. To reduce the distribution error, the following... The radionuclide distribution system also includes dilution lines for diluting the radionuclides.

[0062] In one possible implementation, the dilution pipeline includes a main dilution pipeline 22, a second multi-way valve 23 connected to the main dilution pipeline 22, a dilution bottle 25 connected to the second multi-way valve 23 via a dilution water pipeline 24, a syringe 27 connected to the second multi-way valve 23 via a syringe pipeline 26, and a dilution water slide 28 connected to the syringe 27. The dilution water can be sterile injection water or purified water. The dilution water slide is prior art and will not be described in detail.

[0063] During distribution, after the radionuclide enters the radionuclide bottle 7, the PLC controller 21 controls the second multi-way valve 23 to connect the syringe 27 and the dilution bottle 25. The PLC controller 21 then controls the dilution water slide 28 to draw dilution water into the syringe 27 first. Then, the first multi-way valve 19 is rotated to connect the syringe 27, the second multi-way valve 23, the main dilution line 22, and the first multi-way valve 19. A dilution solution of the same volume as the target water passes through the second multi-way valve 23, the main dilution line 22, and the first multi-way valve 19 in sequence. The liquid injection and distribution pipe 9 is then input into the radionuclide bottle 7 to complete the dilution of the radionuclide and reduce distribution errors.

[0064] When the volume of the diluent is small and the diluent cannot be completely delivered into the radionuclide bottle 7 through the pipeline, this system also adds a dilution pressurization pipeline to blow all the diluent in the pipeline into the radionuclide bottle 7.

[0065] In one possible implementation, the dilution pressurization line includes a second pressurization pipe 29, which is connected to the control valve 30 and the second nitrogen end 31 of the second multi-way valve 23. The control valve 30 is any one of a two-way valve, a three-way valve, a four-way valve, a five-way valve, and a six-way valve.

[0066] When dilution requires pressurization, the first multi-way valve 19 switches to connect the second multi-way valve 23 with the second pressurization pipe 29. The PLC controller 21 controls the control valve 30 to open, and nitrogen gas enters the dilution main pipeline 22, the first multi-way valve 19, and the liquid injection and distribution pipe 9 sequentially from the second multi-way valve 23. Under the positive pressure of nitrogen gas, all the diluent in the pipeline is blown into the radionuclide bottle 7. Example

[0067] Meanwhile, the present invention also provides a method for distributing radionuclides.

[0068] The method for distributing radionuclides includes the following steps: Step S1: Introduce a radioactive nuclide into the radioactive nuclide dispenser 100; The radionuclides from the cyclotron are sequentially fed into the radionuclide distributor 100 via the target water input pipeline 20, the first multi-way valve 19, and the liquid injection and distribution pipeline 9.

[0069] Step S2: The user selects the first distribution terminal 15 for the radionuclide and inputs the first distribution data. The PLC controller 21 calculates the depth of the liquid injection tube 9 inserted into the radionuclide bottle 7 according to the user input distribution data, and controls the slide 6 of the radionuclide dispenser 100 to move. The slide 6 drives the liquid injection tube 9 to be inserted into the radionuclide bottle 7 to a set depth below the liquid surface. Step S3: The PLC controller 21 controls the first reversing valve 16 to open, and nitrogen gas is introduced into the upper part of the radionuclide bottle 7. Under the action of nitrogen positive pressure, the radionuclide between the target water surface and the lower opening of the injection and distribution pipe 9 will be transferred to the designated distribution terminal 15, completing the first distribution of the radionuclide. Step S4: The user selects the next distribution terminal 15 for the radionuclide and enters the distribution amount. Repeat step S3 to complete the next distribution of the radionuclide, and so on, until the user stops the distribution input.

[0070] In the accompanying drawings of this embodiment 3, only the exit points of the two radionuclide distributions are shown. The first distribution enters one distribution terminal 15, and the second distribution enters another distribution terminal 15. In practical applications, the distribution locations and number of distributions can be adjusted as needed. set up.

[0071] When the total volume of target water being distributed is relatively small, a dilution step is included before step S2 to ensure more accurate concentration distribution. Specifically, the PLC controller 21 sends a dilution control signal and controls the second multi-way valve 23 to switch according to the dilution control signal, connecting the syringe 27 to the dilution bottle 25. The slide 6 pulls the syringe 27, drawing the diluent from the dilution bottle 25 into the syringe 27. Simultaneously, the PLC controller 21 calculates the pushing amount of the dilution water slide 28 based on the dilution control signal and controls the dilution water slide 28 to push the syringe 27, injecting the diluent into the radionuclide dispenser 100.

[0072] During dilution, the PLC controller 21 controls the first multi-way valve 19 and the second multi-way valve 23 to connect the syringe 27 to the radionuclide dispenser 100. At this time, the first reversing valve 16 is not energized, and the radionuclide dispenser 100 is connected to the atmospheric end 18 for synchronous exhaust.

[0073] While the invention has been detailed and described in the accompanying drawings and foregoing description, these descriptions and descriptions should be considered illustrative or exemplary rather than restrictive; the invention is not limited to the disclosed embodiments. Other variations of the disclosed embodiments will be understood and practiced by those skilled in the art in practicing the claimed invention through study of the drawings, disclosure, and appended claims.

Claims

1. A radionuclide dispenser (100), comprising a base (1), a support frame (2) disposed on one side of the base (1); a first limit switch (3) and a second limit switch (4) connected to the support frame (2); characterized in that: It also includes a liquid injection and dispensing pipe drive assembly (5) connected to the stand (2); a slide (6) connected to the liquid injection and dispensing pipe drive assembly (5); a radionuclide bottle (7) disposed on the base (1); a first pressurization pipe (8) and a liquid injection and dispensing pipe (9) connected to the radionuclide bottle (7); the liquid injection and dispensing pipe (9) is fixed on the slide (6) and slides up and down with the slide (6).

2. The radionuclide dispenser (100) according to claim 1, characterized in that: The liquid injection and dispensing pipe drive assembly (5) includes a drive motor (51) and a lead screw (52) connected to the drive motor (51).

3. A radionuclide dispenser (100) according to claim 1, characterized in that: The liquid injection and distribution pipe (9) is installed on the slide (6).

4. A radionuclide dispenser (100) according to claim 1, characterized in that: The slide (6) includes a slider (61) and a positioning block connected to each other; the slider (61) is connected to the liquid injection and distribution pipe drive assembly (5); the liquid injection and distribution pipe (9) passes through the positioning block.

5. A radionuclide dispenser (100) according to claim 4, characterized in that: The positioning block includes a first positioning block (62) and a second positioning block (63) that are set separately, and the liquid injection pipe (9) is clamped between the first positioning block (62) and the second positioning block (63).

6. A radionuclide dispenser (100) according to claim 5, characterized in that: The first positioning block (62) is provided with a positioning groove (621), and the slider (61) is fixed in the positioning groove (621).

7. A radionuclide dispenser (100) according to claim 5, characterized in that: The right side wall of the first positioning block (62) is recessed into a first fixing groove (625), and the left side wall of the second positioning block (63) is provided with a second fixing groove (631) corresponding to the first fixing groove (625). The second fixing groove (631) and the first fixing groove (625) form a second through hole, and the liquid injection pipe (9) is clamped in the second through hole.

8. A radionuclide distribution system, characterized in that: The device includes a radionuclide dispenser (100) according to any one of claims 1-7; a first reversing valve (16) connected to the radionuclide dispenser (100) via a first pressurization pipe (8); a first nitrogen end (17) and an atmospheric end (18) connected to the first reversing valve (16); a first multi-way valve (19) connected to the radionuclide dispenser (100) via a liquid injection pipe (9); a target water input pipe (20) connected to the first multi-way valve (19); at least one distribution terminal (15) connected to the first multi-way valve (19) via a branch pipe; and a PLC controller (21) electrically connected to the first multi-way valve (19), the first reversing valve (16), and the radionuclide dispenser (100).

9. A radionuclide distribution system according to claim 8, characterized in that: It also includes a dilution main pipeline (22), a second multi-way valve (23) connected to the dilution main pipeline (22); a dilution bottle (25) connected to the second multi-way valve (23) via a dilution water pipeline (24); a syringe (27) connected to the second multi-way valve (23) via a syringe pipeline (26); and a dilution water slide (28) connected to the syringe (27).

10. A method for distributing radionuclides, characterized in that: The steps include the following: Step S1: Introduce a radionuclide into the radionuclide dispenser (100); Step S2: The user selects the first distribution terminal (15) for the radionuclide and inputs the first distribution data. The PLC controller (21) calculates the depth of the liquid injection tube (9) inserted into the radionuclide bottle (7) according to the user input data, and controls the slide (6) of the radionuclide dispenser (100) to move. The slide (6) drives the liquid injection tube (9) to be inserted into the radionuclide bottle (7) to a set depth below the liquid surface. Step S3: The PLC controller (21) controls the first reversing valve (16) to open, and nitrogen gas is introduced into the upper part of the radionuclide bottle (7). Under the action of nitrogen positive pressure, the radionuclide between the target water surface and the lower opening of the liquid injection pipe (9) will be transferred to the designated distribution terminal (15) to complete the first distribution of the radionuclide. Step S4: The user selects the next distribution terminal (15) for the radionuclide and enters the distribution amount. Step S3 is repeated to complete the next distribution of the radionuclide. This process continues until the user stops inputting the distribution information.

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