A composition containing esprosulanc and flonicamid

Abstract

The present application provides a composition containing esprosulanc and flonicamid, wherein the weight ratio of esprosulanc to flonicamid is 20:1 to 1:80. The present application also relates to the use of the composition for controlling agricultural insects, and has a synergistic effect.

Description

Technical Field

[0001] The present invention belongs to the field of agriculture, and in particular relates to a composition containing essolana and flonicamid and an application thereof. Background Art

[0002] Esafoxolaner is an isoxazoline substance that is known to be used in the veterinary medicine field as an external anthelmintic. It kills both ticks and fleas and has the characteristics of rapid onset of action and high safety.

[0003] Fluniciamide (dinotefuran) is a neonicotinoid insecticide that mainly acts on the posterior membrane of the insect's nerve junction, blocking the insect's normal nerve transmission. By binding to acetylcholine receptors, it causes the insect to become abnormally excited, suffer convulsions, paralyzed and die. It has excellent preventive effects on piercing-sucking mouthpart pests, and has contact, stomach poison and systemic activity. It has a long lasting effect and a broad insecticide spectrum. It is mainly used to control aphids, leafhoppers, planthoppers, thrips, whiteflies and their resistant strains on various crops such as wheat, rice, cotton, vegetables, fruit trees, and tobacco leaves. It is also highly effective against pests of the orders Coleoptera, Diptera, Lepidoptera and Homoptera, and is also highly effective against sanitary pests such as cockroaches, fleas, termites, and houseflies.

[0004] CN109068651A discloses a composition comprising an isoxazoline compound and at least one additional active agent, wherein the isoxazoline compound may be a compound of structure (S-Ia) (i.e., essolana), and the additional active agent may be abamectin, etc. The composition is used in the field of veterinary medicine.

[0005] No reports related to the combination of essolana and flonicamid were found in the prior art. SUMMARY OF THE INVENTION

[0006] The present inventors have discovered through research that essolana and flonicamid have a synergistic effect in insect control. Based on this, the present invention was completed.

[0007] The present invention relates to a composition containing essolana and flonicamid, wherein the weight ratio of essolana to flonicamid is 20:1 to 1:80.

[0008] The composition according to the present invention is characterized in that the weight ratio of essolana to flonicamid is preferably 10:1 to 1:40.

[0009] The composition according to the present invention is characterized in that it further comprises an agriculturally acceptable adjuvant and / or carrier.

[0010] The composition according to the present invention is characterized in that the pesticide composition is prepared into a suspension concentrate, an aqueous emulsion, a wettable powder, a water-dispersible granule, an emulsifiable concentrate, or a microemulsion.

[0011] The composition according to the present invention is characterized in that the weight percentage of the active ingredient in the composition is 1-90%.

[0012] The composition of the present invention is used for preventing and controlling agricultural insects.

[0013] The use according to the present invention is characterized in that the agricultural insects are preferably Hemiptera insects.

[0014] The method for using the composition of the present invention for controlling agricultural insects is characterized in that the composition is brought into contact with the agricultural insects; or the composition is applied to the living environment of the agricultural insects. Detailed Description of the Invention

[0016] In one aspect, the present invention provides a composition containing essolana and flonicamid, wherein the weight ratio of essolana to flonicamid in the composition is 20:1 to 1:80.

[0017] Preferably, the weight ratio of essolana to flonicamid is 10:1 to 1:40, more preferably 1:1-20, for example 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 11:8, 1:19, 1:20, and most preferably 1:5 to 1:10.

[0018] In one embodiment of the present invention, the composition further comprises an agriculturally acceptable adjuvant and / or carrier, and the pesticide composition is prepared into a suspension concentrate, emulsion in water, wettable powder, water-dispersible granules, emulsifiable concentrate, or microemulsion. Preferably, the composition is prepared into a suspension concentrate, emulsion in water, water-dispersible granules, or wettable powder.

[0019] In the preparation, the total amount of active ingredients is 1-90%, preferably 5-60%, more preferably 5-50%.

[0020] Agriculturally acceptable adjuvants and / or carriers include, but are not limited to, dispersants, wetting agents, emulsifiers, solvents, thickeners, antifreeze agents, adhesives, disintegrants, defoaming agents, carriers, etc.

[0021] The dispersant can be selected from one or more of nonylphenol polyoxyethylene ether, glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, alkyl naphthalene sulfonate, naphthalene sulfonate formaldehyde condensate, naphthalenesulfonic acid formaldehyde condensate sodium salt, lignin sulfonate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, dodecyltrimethylammonium salt, alkyldimethylbenzylammonium salt, p-methoxy fatty acid amide benzene sulfonic acid, p-methoxy fatty acid amide benzene sulfonate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, and polyoxyethylene sorbitan fatty acid ester.

[0022] The wetting agent can be selected from one or more of sodium lauroyl sarcosinate, sodium N-lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium lauryl sulfate, calcium dodecylbenzenesulfonate, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, triphenethyl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, polyoxyethylene fatty acid ester, higher fatty acid glyceride, sorbitan fatty acid ester, fatty alcohol polyoxyethylene ether, and alkylphenol polyoxyethylene ether phosphate.

[0023] The emulsifier can be selected from one or more of lignin sulfonate, naphthalene sulfonate formaldehyde condensate, benzyl dimethylphenol polyoxyethyl ether, styrylphenyl polyoxyethylene ether, phenylethylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, alkylphenol formaldehyde resin polyoxyethylene ether, polyoxyethylene sorbitol fatty acid ester, sodium lauryl sulfate, sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, nonylphenol polyoxyethylene ether phosphate, phenylphenol polyoxyethyl ether phosphate, styrene polyoxyethylene ether sulfate ammonium salt, sorbitan monostearate, anhydrous sorbitan monostearate polyoxyethylene ether, and anhydrous sorbitan fatty acid ester polyoxyethylene ether.

[0024] The solvent can be selected from one or more of acetone, dimethylformamide, dimethyl sulfoxide, xylene, chloroform, dichloromethane, ethyl acetate, cyclohexane, ethyl glycol ether, cyclohexanone, N-methylpyrrolidone, coconut fatty acid methyl ester, cyclohexanol, methyl glycol ether, acetonitrile, paraffin, tetralin, isophorone, soybean oil, cottonseed oil, methylated vegetable oil, and dimethyl phthalate.

[0025] The thickener can be selected from one or more of gum arabic, carboxymethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, gelatin, polyvinyl alcohol, magnesium aluminum silicate, and sodium alginate.

[0026] The antifreeze agent can be selected from one or more of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, and sorbitol.

[0027] The binder can be selected from one or more of starch, dextrin, sucrose, carboxymethyl cellulose, carboxyethyl cellulose, gelatin, gum arabic, and xanthan gum.

[0028] The disintegrant can be selected from one or more of sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate, magnesium chloride, sodium carboxymethyl starch, and urea.

[0029] The defoaming agent can be selected from one or more of silicone, butyl phosphate, isobutyl phosphate, and n-octanol.

[0030] The carrier can be selected from one or more of diatomaceous earth, kaolin, bentonite, attapulgite, montmorillonite, calcium carbonate, zeolite, acidic clay, water, castor oil, soybean oil, corn oil, turpentine, rapeseed oil, methyl oleate, coconut oil, and mineral oil.

[0031] Another aspect of the present invention relates to the use of the composition for controlling agricultural insects, wherein:

[0032] Applicable agricultural plants include:

[0033] Crops: rice, wheat, barley, sorghum, corn, cotton, soybeans, beans, peanuts, buckwheat, sugar beets, rapeseed, sunflowers, sugarcane, tobacco, etc.

[0034] Vegetables: cucumber, eggplant, tomato, winter melon, potato, radish, mustard greens, kohlrabi, cabbage, kale, broccoli, etc.

[0035] Fruit trees: apple, peach, cherry, apricot, citrus, lemon, blueberry, grape, banana, etc.

[0036] Agricultural insects that can be controlled include:

[0037] Lepidoptera: Diamondback moth ( Plutellaxylostella ),cabbage caterpillar( PierisrapaeLinnaeus )、Fall armyworm( Spodopterafugiperda )、Farmworm( Spodopterafrugiperda ), Looper( Rachiplusianu ), soybean armyworm ( Pseudoplusiaincludens ), Noctuidae ( Sesamiainferens ), Rice leaf roller ( CnaphalocrocismedinalisGuenee ), stem borer ( Chilo suppressalis ), tomato leafminer ( Tutaabsoluta ), Spodoptera littoralis ( Trichoplusiani )、Powdery stem borer( Sesamianonagrioides ), Trichoplusia ni ( Trichoplusiani ) 、Spodoptera brassicae ( Mamestrabrassicae ), Citrus leafminer ( Phyllocnistiscitrella )、Pear borer ( Grapholithamolesta ), American armyworm ( PseudaletiaunipunctaHaworth )、Cotton moth ( EariasvittellaFabricius )、Cotton brown banded moth ( Adoxophyesorana ), pink bollworm ( PectinophoragossypiellaSaunders ), cotton bollworm ( HelicoverpaarmigeraHübner ), cotton bollworm ( Heliothisarmigera )、Cuttail borer( Scirpophagaincertulas ), beet armyworm ( SpodopteraexiguaHübner )、Plutella xylostella( Plutellaxylostella )、small cutworm( Agrotisypsilon ), Spodoptera litura ( Spodopteralitura ), corn borer ( OstrinianubilalisHübner ).

[0038] Diptera: Aedes aegypti ( Aedesaegypti ), Rapeseed leafminer ( Liriomyzabrassicae )、Onion Fly( Phorbiaantiqua ), Mediterranean fruit fly ( Ceratitiscapitata ), cabbage fly ( Deliaradicum )、Melon fruit fly ( Bactroceracucurbitae ), carrot stem fly ( Psilarosae )、housefly( MuscadomesticaLinnaeus )、Oriental fruit fly ( Bactroceradorsalis ), wheat field flies ( Deliacoarctata )、Red wheat midge ( Sitodiplosismosellana ), wheat gall midge ( Mayetioladestructor ), Aedes mosquito ( Culextarsalis ), American leafminer ( Liriomyzatrifolii ), Sheep Lice Fly ( Melophagusovinus ), Apple fruit fly ( Rhagoletispomonella ), cherry fruit fly ( Rhagoletiscerasi ), rapeseed leaf gall midge ( Dasineurabrassicae ), olive fruit fly ( Dacusoleae ), purple lucerne leafminer ( Agromyzafrontella ).

[0039] Hemiptera: White-backed Planthopper ( SogatellafurciferaHorvath )、Whitefly( Trialeurodesvaporariorum ), broad bean aphid ( AphisfabaeScopoli ), strawberry root aphids ( Aphisforbesi ), large rice stink bug ( Leptocorisaoratorius ), soybean aphid ( Aphisglycines ), Euphorbia longituba ( Macrosiphumeuphorbiae )、Nipponia lugens( Nilaparvatalugens )、Green stink bug ( NezaraviridulaLinnaeus )、Cabbage aphids( Brassica oleracea ), sweet potato whitefly ( Bemisia tabaci ), citrus psyllid ( Diaphorin citrus )、Black-spotted Shield Scale ( Parlatoriaziziphi ), black-tailed leafhopper ( Nephotettix nigropictus )、Red wax scale ( Red waxy wax ), Red Round Scale ( Aonidiella aurantii )、Small brown planthopper( Laodelphax striatellus), Cowpea aphid ( AphiscraccivoraKoch ), Schizaphis citrinum ( Toxoptera aurantiiand ), pear psylla ( Psyllapiri ), Aphididae SitobionavenaeFabricius ), wheat aphid ( Schizaphis gramineum ), wheat aphid ( Diuraphisnoxia ), wheat aphid ( Metopolophium dirhodum )、Red cotton bug ( Dysdercus cingulatus ), Cotton red-belled stink bug ( Leptoglossus phyllopus )、Aphids spp.( Aphisgossypii Glover ), apple aphid ( Aphids ), apple psyllid ( Psyllamal ), grape phylloxera ( Viteus vitifolii ), grape phylloxera ( Phylloxera avitifolia )、Myzus persicae( Myzus persicae Sulzer ), greenhouse whitefly ( Trialeurodesvaporariorum )、small brown rice hopper ( LaodelphaxstriatellusFallen ), Bemisia tabaci ( Bemisia tabaci Gennadius )、Leafhopper( Empoascaspp .), corn wax cicada ( Pilgrim maids Ashmead ), corn aphid ( Rhopalosiphummaidis ).

[0040] Thysanoptera: rice thrips ( Baliothrips biformis ), Thrips tabaci ( Frankliniella fusca ), western flower thrips ( Frankliniella occidentalis ), Thrips citriodora ( Scirtothripscitri ), Ochrothrips truncatula ( Scirtothrips dorsalis ), yellow-breasted thrips ( Thripshawiensis ), Thrips leucoderma Black-haired thrips ), Oriental thrips ( Thrips orientalis );

[0041] Hymenoptera: Argentine ant ( Iridomyrmex humilis ), black fire ants ( Solenopsisrichteri ), Red Imported Fire Ant ( Solenopsis invicta ), Red Ants( Pogonomyrmex barbatus ),wasp( Polistes rubiginosa )、Yellow-edged Wasp ( Wasp spider )、Ichthyophthirius ( Dolichovespulamaculata ), Cleometheus ( Crematogaster ), Southern Fire Ant ( Solenopsis xyloni ), leaf-cutter ants ( Attacephalotes ), tropical fire ants ( Solenopsis geminata ), Velvet Ant( Dasymutilla occidentalis )、Small Black Ant( Monomoriumminimum ), Xinjiang sawfly ( Athaliaroses ).

[0042] Coleoptera: Egyptian cloverleaf weevil ( Hyperabrunneipennis ), dark-colored click beetle ( Dark Agriotes )、Cabbage Seed Turtle Elephant( Ceutorhynchussimilis), Phaseolus vulgaris ( Acanthoscelides obtectus ), broad bean weevil ( Bruchus rufimanus ), Strawberry root weevil ( Otiorrhynchus ovatus ), cotton boll weevil ( AnthonomusgrandisBoheman ), cotton boll weevil ( Anthonomusgrandis ), Mexican bean beetle ( Epilachnavarivestis ), South American leaf beetle ( Diabrotica speciosa )、Four-striped bean weevil( Callosobruchus maculatus ), pea weevils ( Bruchuspisorum ), corn root beetle ( Diabrotica virgifera ), corn root beetle ( Diabroticavirgif eravirgiferaLeConte ), corn beetle ( Common grebe ), corn weevil( Sitophiluszeamais ), bluegrass weevil ( Listronotus maculicollisDietz ), Cloverleaf Weevil ( Hyperapostle ).

[0043] Orthoptera: East Asian migratory locust ( Locusts ), African mole cricket ( Gryllotalpa africana ), mole crickets ( Scapteriscus vicinus Scudder ), American Desert Locust ( Schistocerca americana ), American grasshopper ( Schistocerca americana Drury ), migratory black locust ( Melanoplussanguinipes ), migratory locusts ( Locustsmigratory Linnaeus ), migratory grasshoppers ( Melanoplussanguinipes Fabricius 、Desert Locust( SchistocercagregariaForskal ), Stone-dwelling Black Locust( Melanoplusspret ), two-striped black locust ( Melanoplus bivittatus ), Striped Red Locust ( Nomadacris septemfasciata ), Brown Migratoria ( Locust pardalina ).

[0044] In a preferred embodiment of the present invention, the agricultural insects are selected from Hemiptera insects, including cotton aphids ( Aphisgossypii Glover )、Myzus persicae( Myzus persicae Sulzer ), Schizaphis citrinum ( Toxoptera aurantiiand ), Aphididae SitobionavenaeFabricius ), wheat aphid ( Schizaphis gramineum ), apple aphid ( Aphids ), corn aphid ( Rhopalosiphummaidis )、Whitefly( Trialeurodesvaporariorum )、Nipponia lugens( Nilaparvatalugens )、Small brown planthopper( Laodelphax striatellus ), pear psylla ( Psyllapiri ). Preferably, it is cotton aphid ( Aphisgossypii Glover )、Myzus persicae( Myzus persicae Sulzer ), Aphididae SitobionavenaeFabricius ).

[0045] Another aspect of the present invention relates to a method for controlling agricultural insects using the composition of the present invention, characterized in that the composition is contacted with the agricultural insects, or the composition is applied to the living environment of the agricultural insects. DETAILED DESCRIPTION

[0046] The present invention will be further described below in conjunction with the embodiments, but the present invention is not limited thereto. In addition, unless otherwise specified, the percentages described in the following embodiments are all weight percentages.

[0047] 1. Combined toxicity test

[0048] Test subjects: cotton aphid ( Aphisgossypii Glover ), select healthy and uniform-sized 4-5th instar nymphs.

[0049] Test agents: essolana technical and flonicamid technical; both were purchased commercially.

[0050] The test method refers to the "Insecticide Indoor Bioassay Test Guidelines NY / T 1154.6-2006" Insecticide Part 6 "Insecticide Immersion Method" and the "Insecticide Indoor Bioassay Test Guidelines NY / T 1154.7-2006" Insecticide Part 7 "Determination of Combined Action of Mixtures" to test the indoor biological activities of A, B and their combinations in different proportions against cotton aphids.

[0051] Dissolve the treatment agent in acetone according to the ratios specified in Table 1 below, then prepare a series of concentrations (calculated based on the active ingredient) using a 1% Tween 80 aqueous solution. Inoculate 20 aphids per cotton seedling. Then, immerse the seedlings and test insects in the prepared agent. After 5 seconds, remove the seedlings, remove the excess solution, and insert them into an absorbent sponge. Cover the seedlings with a glass cover. After 48 hours, examine the number of live and dead insects. Repeat the experiment three times, average the results, calculate the adjusted mortality rate, and calculate the LC for each treatment. 50 The co-toxicity coefficient (CTC) of each treatment was then calculated according to the Sun Yun-Sun Yunpei method to evaluate synergistic effects. A CTC value of < 80 indicates antagonism, 80 ≤ CTC ≤ 120 indicates additive effects, and CTC > 120 indicates synergistic effects.

[0052] Toxicity index (TI) = standard agent LC 50 / Test reagent LC 50 ×100

[0053] Measured mixed toxicity index (ATI) = standard agent LC 50 / Mixed Pharmacy LC 50 ×100

[0054] Theoretical Toxicity Index (TTI) = TI A ×PA +TI B ×P B

[0055] Co-toxicity coefficient (CTC) = measured toxicity index (ATI) / theoretical toxicity index (TTI) × 100

[0056] in:

[0057] TI A represents the toxicity index of agent A;

[0058] TI B represents the toxicity index of agent B;

[0059] P A Represents the percentage of agent A in the mixture;

[0060] P B Represents the percentage of agent B in the mixture;

[0061] Table 1 Combined toxicity results of each treatment

[0062]

[0063] The table above shows that essolana and flonicamid have a synergistic effect in the range of 10:1 to 1:40, with the synergistic effect being more pronounced in the range of 1:1 to 1:20.

[0064] 2. Preparation Examples

[0065] Example 1 Water dispersible granules

[0066] Essolana 5%, flonicamid 25%, sodium sulfate of fatty alcohol polyoxyethylene ether 12%, polyoxyethylene trisiloxane ether 7%, magnesium aluminum silicate 8%, sodium sulfate 7%, attapulgite balance.

[0067] The preparation method comprises the following steps: uniformly mixing and crushing the components except the binder, then adding the binder aqueous solution to granulate the mixture, and drying the mixture to obtain water-dispersible granules.

[0068] Example 2 Water Dispersible Granules

[0069] Essolana 1%, flonicamid 10%, naphthalenesulfonic acid formaldehyde condensate sodium salt 5%, triphenyl phenol polyoxyethylene ether 5%, magnesium aluminum silicate 4%, sodium sulfate 4%, attapulgite balance.

[0070] The preparation method is the same as that of Example 1.

[0071] Example 3: Wettable powder

[0072] Essolana 8%, flonicamid 8%, nonylphenol polyoxyethylene ether 6%, calcium dodecylbenzenesulfonate 5%, diatomaceous earth balance.

[0073] The preparation method comprises the following steps: mixing the components, grinding and pulverizing the components to obtain a wettable powder.

[0074] Example 4: Wettable powder

[0075] Essolana 1%, flonicamid 20%, naphthalenesulfonic acid formaldehyde condensate sodium salt 4%, sorbitan fatty acid ester 7%, diatomaceous earth balance.

[0076] The preparation method is the same as Example 3.

[0077] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition containing essolana and flonicamid, characterized in that: The weight ratio of essolana to flonicamid is 10:1 to 1:

40.

2. The composition according to claim 1, characterized in that The composition may further comprise an agriculturally acceptable adjuvant and / or carrier.

3. The composition according to claim 2, characterized in that The composition can be prepared into suspension, aqueous emulsion, wettable powder, water-dispersible granule, emulsifiable concentrate and microemulsion.

4. The composition according to claim 3, characterized in that The weight percentage of the active ingredient in the composition is 1-90%.

5. Use of the composition according to any one of claims 1 to 4 for controlling agricultural insects, characterized in that: The agricultural insect is cotton aphid.

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