A scalp conditioning and repairing composition, its preparation method and application

Abstract

The present invention discloses a scalp conditioning and repairing composition, its preparation method and application, relating to the technical field of washing and care products. The present invention discloses a scalp conditioning and repairing composition, comprising the following components in parts by weight: 15-30 parts of sodium gluconate, 10-25 parts of sodium lactate, and 1-5 parts of zinc salt; the zinc salt is at least one of a water-soluble zinc salt and a fat-soluble zinc salt; the water-soluble zinc salt is at least one of zinc gluconate, zinc lactate, zinc chloride, and zinc acetate, and the fat-soluble zinc salt is at least one of zinc palmitate, zinc salicylate, zinc stearate, and zinc oxide. The present invention provides a scalp conditioning and repairing composition, which can reduce the degreasing power of the surfactant on the scalp, reduce the transepidermal water loss rate, reduce skin dryness and itching, and at the same time can repair scalp cells, control excessive sebum secretion, and maintain scalp health.

Description

Technical Field

[0001] The present invention relates to the technical field of washing and care products, in particular to a scalp conditioning and repairing composition, a preparation method thereof and an application thereof. Background Art

[0002] In the past, in people's consciousness and behavior, they often only paid attention to hair care, thus neglecting scalp care; little did they know that factors such as bad work and rest habits, external pressure, air pollution, surfactants and other chemical raw materials would cause scalp problems such as itching, dandruff, oiliness, peculiar smell, erythema, hair loss, aging and so on. In order to achieve the anti-dandruff effect, traditional shampoos often have strong detergency and are likely to damage the scalp, so scalp care is becoming more and more important.

[0003] While washing products remove dirt, they inevitably wash away skin lipids and natural moisturizing factor NMF (Nature Moisture Factor). The reduction of natural moisturizing factor (NMF) and lipid barrier in damaged skin leads to an increase in transepidermal water loss (TEWL), making the skin dry, red and itchy. In dry seasons, the excessive degreasing power of shampoo disrupts the normal renewal of the scalp cutin layer, and the retaliatory growth of the scalp cutin layer causes dry dandruff. Summary of the Invention

[0004] Based on this, the purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art and provide a scalp conditioning and repairing composition, a preparation method thereof and an application thereof.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is as follows: A scalp conditioning and repairing composition, comprising the following components in parts by weight: 15-30 parts of sodium gluconate, 10-25 parts of sodium lactate, 1-5 parts of zinc salt; the zinc salt is at least one of a water-soluble zinc salt and a fat-soluble zinc salt; the water-soluble zinc salt is at least one of zinc gluconate, zinc lactate, zinc chloride, zinc acetate, and the fat-soluble zinc salt is at least one of zinc palmitate, zinc salicylate, zinc stearate, zinc oxide.

[0006] The present invention provides a scalp conditioning and repairing composition, which can reduce the degreasing power of surfactants on the scalp, reduce the trans-epidermal water loss rate, reduce skin dryness and itching, and at the same time can repair scalp cells, control excessive oil secretion, reduce scalp inflammation and maintain scalp health. Sodium lactate, sodium gluconate and zinc salt in the scalp conditioning and repairing composition can further enlarge the original surfactant micelles, reduce the number of surfactants infiltrating into the cutin layer, reduce the degreasing property and control oil secretion. The scalp conditioning and repairing composition can cover the scalp surface to play a protective role, and at the same time helps to accelerate the growth and repair of scalp cells, play a role in repair and moisturization, and reduce TEWL (trans-epidermal water loss).

[0007] Preferably, the zinc salt is a mixture of a water-soluble zinc salt and a fat-soluble zinc salt, wherein the weight ratio of the water-soluble zinc salt to the fat-soluble zinc salt is (3 - 5):(1 - 2).

[0008] The inventors found in the actual experiment process that when the zinc salt is a mixture of a water-soluble zinc salt and a fat-soluble zinc salt, the effects of oil control, moisturizing, repair, and anti-dandruff are better. The reasons are as follows: (1) Sodium gluconate and sodium lactate can help regulate the pH value of the shampoo, making it closer to the natural acid-base balance of the scalp, reducing irritation and promoting scalp health, and helping to reduce dandruff production. At the same time, the water-soluble zinc salt and the fat-soluble zinc salt have anti-inflammatory ability and the effect of inhibiting fungal growth. The zinc salt synergizes with sodium gluconate and sodium lactate to more effectively maintain scalp health and reduce the formation of dandruff, and the anti-dandruff effect is better. (2) Sodium gluconate and sodium lactate synergize to better regulate the oil secretion of the scalp, keeping the scalp at an appropriate oil content. At the same time, the presence of the fat-soluble zinc salt forms a protective film on the surface of the hair and the scalp. On the one hand, it reduces the direct contact between the water-soluble zinc salt and the scalp and hair, thereby reducing irritation; on the other hand, it prevents the damage of oxygen and moisture in the air to the hair and scalp, keeping the hair and scalp healthy and improving hair luster. It can also further protect the scalp steady-state environment adjusted by the synergism of sodium gluconate and sodium lactate. Therefore, the zinc salt synergizes with sodium gluconate and lactic acid to more effectively regulate the oil secretion of the scalp and improve the oil control effect. (3) When the scalp conditioning and repair composition provided by the present invention is specifically applied in the shampoo, sodium lactate, sodium gluconate, and zinc salt in the scalp conditioning and repair composition can further enlarge the original surfactant micelles, reduce the number of surfactants infiltrating into the stratum corneum, reduce the degreasing property, and further control the oil secretion. Sodium lactate, sodium gluconate, and zinc salt in the scalp conditioning and repair composition also help to accelerate the growth and repair of scalp cells, play a role in repair and moisturizing, and reduce TEWL (transepidermal water loss). (4) The water-soluble zinc salt can penetrate well into the hair interior, while the fat-soluble zinc salt mainly acts on the hair surface. The synergistic effect of the two can make zinc ions penetrate into the inner and outer parts of the hair, exerting a comprehensive effect. (5) Sodium gluconate and sodium lactate have a certain moisturizing effect. And the zinc salt can also prevent water loss by forming a protective film. Therefore, the coexistence of the two can produce a dual moisturizing effect. (6) The zinc salt, sodium gluconate, and sodium lactate all have a certain antioxidant ability. Their synergistic effect can better scavenge free radicals and protect the hair and scalp.

[0009] Preferably, the water-soluble zinc salt is a mixture of zinc gluconate and zinc lactate; wherein, the weight ratio of zinc gluconate to zinc lactate is 1:(1 - 3).

[0010] Preferably, the fat-soluble zinc salt is a mixture of zinc palmitate and zinc salicylate; wherein, the weight ratio of zinc palmitate to zinc salicylate is 1:(1 - 3).

[0011] During the actual experiment, the inventors found that when the water-soluble zinc salt is a mixture of zinc gluconate and zinc lactate, and the fat-soluble zinc salt is a mixture of zinc palmitate and zinc salicylate, they can better exert a synergistic effect with sodium gluconate and sodium lactate. Sodium gluconate and sodium lactate can produce ionic interaction with zinc gluconate and zinc lactate and form hydrogen bonds, enhancing the moisturizing ability while controlling sebum secretion, inhibiting the reproduction of Malassezia, and soothing scalp inflammation. Zinc palmitate and zinc salicylate can adsorb on the scalp and continuously play a role. In short, the synergistic effect of water-soluble and fat-soluble zinc salts with sodium gluconate and sodium lactate can exert comprehensive effects such as multi-faceted moisturizing, oil control, repair, and anti-inflammation, thus making the efficacy of the shampoo more perfect.

[0012] Moreover, during the actual experiment, the inventors found that the weight ratio of zinc gluconate to zinc lactate in the water-soluble zinc salt and the weight ratio of zinc palmitate to zinc salicylate in the fat-soluble zinc salt will further affect the synergistic effect of the components. When the water-soluble zinc salt is a mixture of zinc gluconate and zinc lactate; wherein, the weight ratio of zinc gluconate to zinc lactate is 1:(1 - 3), and the fat-soluble zinc salt is a mixture of zinc palmitate and zinc salicylate; wherein, the weight ratio of zinc palmitate to zinc salicylate is 1:(1 - 3), when the scalp conditioning and repairing composition provided by the present invention is applied to shampoo, the effects in all aspects are better.

[0013] Preferably, the scalp conditioning and repairing composition further comprises 0.1 - 3.5 parts of a humectant and 1 - 5 parts of an emollient.

[0014] Preferably, the humectant is at least one of D, L-panthenol and sodium hyaluronate, and the emollient is at least one of caprylic / capric glycerides and hydrogenated polydecene.

[0015] Preferably, the emollient is PEG-8 caprylic / capric glyceride.

[0016] During the actual experiment, the inventors found that PEG-8 caprylic / capric glyceride has good emollient properties, which can enhance the conditioning ability of the composition, supplement the lipids removed by the surfactant, and prevent the scalp from being overly dry. It can better synergistically enhance the effects with sodium gluconate, sodium lactate, and zinc salt in the scalp conditioning and repairing composition, and relieve scalp problems.

[0017] In addition, the present invention provides the application of the scalp conditioning and repairing composition in hair care products.

[0018] Further, the present invention provides a washing and care product, which is a shampoo and comprises the following components in parts by weight, with a total of 100 parts by weight: disodium ethylenediaminetetraacetate 0.05 - 0.3 parts, ammonium lauryl ether sulfate 5 - 20 parts, ammonium lauryl sulfate 2 - 10 parts, coconut fatty acid monoethanolamide 1 - 3 parts, pearlescent flakes 0.5 - 1 part, alkyl phthalic amide 0.1 - 3 parts, guar gum 0.1 - 1 part, allantoin 0.1 - 1 part, cocamidopropyl betaine 1 - 10 parts, polyquaternium-22 0.1 - 1 part, preservative 0.02 - 1 part, dimethicone emulsion 2 - 5 parts, sodium chloride 0.1 - 1 part, the scalp conditioning and repair composition 1 - 15 parts, essence 0.05 - 0.5 part, deionized water in the balance.

[0019] Preferably, the present invention provides a washing and care product, which comprises the following components in parts by weight, with a total of 100 parts by weight: disodium ethylenediaminetetraacetate 0.1 part, ammonium lauryl ether sulfate 8 parts, ammonium lauryl sulfate 7 parts, coconut fatty acid monoethanolamide 1.4 parts, pearlescent flakes 0.6 part, alkyl phthalic amide 0.5 part, guar gum 0.25 part, allantoin 0.2 part, cocamidopropyl betaine 5 parts, polyquaternium-22 0.6 part, Esonal-OSM-510Plus (Meier Biology) 0.8 part, dimethicone emulsion 3.3 parts, sodium chloride 0.3 part, the scalp conditioning and repair composition 5 parts, essence 0.1 part, deionized water in the balance.

[0020] Preferably, in the actual shampoo formulation, the dimethicone emulsion comprises dimethicone emulsion DC-1785 and dimethicone emulsion DC-7137, wherein, the dimethicone emulsion comprises 1.8 parts of dimethicone emulsion DC-1785 and 1.5 parts of dimethicone emulsion DC-7137.

[0021] Preferably, in the actual shampoo formulation, the preservative is hexamidine di(2-hydroxyethylsulfonate) or Esonal-OSM-510Plus (Meier Biology).

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) Sodium gluconate and sodium lactate have certain acidity, which can soften the keratin on the scalp and help remove dandruff. At the same time, water-soluble zinc salt and fat-soluble zinc salt also have the effect of inhibiting the growth of fungi. The zinc salt synergizes with sodium gluconate and lactic acid to more effectively control the formation of dandruff and achieve better anti-dandruff effect. (2) Sodium gluconate and sodium lactate synergize to better regulate the oil secretion of the scalp and keep the scalp with an appropriate oil content. At the same time, the presence of fat-soluble zinc salt forms a protective film on the surface of the hair and scalp. On the one hand, it reduces the direct contact between water-soluble zinc salt and the scalp and hair, thus reducing irritation; on the other hand, it prevents the damage of oxygen and moisture in the air to the hair and scalp, keeps the hair and scalp healthy, improves the hair luster, and can further protect the scalp steady-state environment adjusted by the synergism of sodium gluconate and sodium lactate. Therefore, the zinc salt synergizes with sodium gluconate and lactic acid to more effectively regulate the oil secretion of the scalp and improve the oil control effect. (3) When the scalp conditioning and repairing composition provided by the present invention is specifically applied in shampoo, sodium lactate, sodium gluconate, and zinc salt in the scalp conditioning and repairing composition can further enlarge the original surfactant micelles, reduce the number of surfactants infiltrating into the stratum corneum, reduce the degreasing property, and further control the oil secretion. Sodium lactate, sodium gluconate, and zinc salt in the scalp conditioning and repairing composition also help to accelerate the growth and repair of scalp cells, play a role in repair and moisturization, and reduce TEWL (transepidermal water loss). (4) Water-soluble zinc salt can penetrate well into the hair interior, while fat-soluble zinc salt mainly acts on the hair surface. The synergistic effect of the two enables zinc ions to penetrate into the internal and external parts of the hair and exert comprehensive effects. (5) Sodium gluconate and sodium lactate have certain moisturizing effects. And zinc salt can also prevent water loss by forming a protective film. Therefore, the coexistence of the two can produce a dual moisturizing effect. (6) Zinc salt, sodium gluconate, and sodium lactate all have certain antioxidant abilities. Their synergistic effect can better scavenge free radicals and protect the hair and scalp. Detailed embodiments

[0023] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. In the embodiments, the experimental methods used are all conventional methods unless otherwise specified, and the materials, reagents, etc. used can be obtained from commercial channels unless otherwise specified.

[0024] Examples 1-12 and Comparative Examples 1-6

[0025] The present invention provides a scalp conditioning and repairing composition. The components and parts by weight of the scalp conditioning and repairing composition are shown in Table 1-2 below, and the total parts by weight in the scalp conditioning and repairing composition is 100 parts.

[0026] The preparation method of the scalp conditioning and repairing composition comprises the following steps:

[0027] Sodium gluconate and sodium lactate are dissolved in water. The zinc salt is first mixed with the esterifying agent and then added to water and heated and mixed, and then the humectant is added and mixed evenly.

[0028] Application examples

[0029] The present invention provides a washing and care product, and the washing and care product is a shampoo, which comprises the following components in parts by weight, and the total parts by weight is 100 parts: Phase A: 0.1 part of disodium ethylenediaminetetraacetate, 8 parts of ammonium lauryl ether sulfate, 7 parts of ammonium lauryl sulfate, 1.4 parts of coconut fatty acid monoethanolamide, 0.6 part of pearlescent flakes, 0.5 part of alkyl phthalic amide, 0.25 part of guar gum, 0.2 part of allantoin; Phase B: 5 parts of cocoamidopropyl betaine, 0.6 part of polyquaternium-22, 0.8 part of Esonal-OSM-510Plus (Meier Biology); Phase C: 1.8 parts of dimethicone emulsion DC-1785, 1.5 parts of dimethicone emulsion DC-7137, 0.3 part of sodium chloride, 5 parts of the scalp conditioning and repairing composition, 0.1 part of essence, and the balance of deionized water.

[0030] The preparation method of the shampoo comprises the following steps:

[0031] Phase A is heated and dissolved and cooled to 40 °C, Phase B is mixed evenly at room temperature and then added to Phase A, and Phase C is added to Phase A one by one and mixed evenly to obtain the shampoo.

[0032] Table 1

[0033]

[0034]

[0035] Table 2

[0036]

[0037]

[0038] Performance test 1

[0039] Test process and standards:

[0040] In the experiment, 90 healthy people were selected, with five people in each group, aged 20 - 50 years old, having a scalp condition of moderate dandruff and moderate scalp greasiness, and a current situation of sensitivity and itching. All the subjects voluntarily participated in the experiment and signed an informed consent form. The subjects could not wash their hair by themselves and could not use any other hair products during the test and the follow-up test period after the washing period.

[0041] Select 5 test points on the scalp at the top of the volunteers' heads, measure the initial transepidermal water loss rate and scalp sebum amount, and record the positions of the test points. Regularly use a skin moisture loss tester Tewameter TM300 to detect the transepidermal water loss rate (TEWL) of the test points in each group every week for 28 consecutive days, and take the average value. Use a sebum tester Sebumeter SM815 to measure the scalp sebum amount in a specific area. Measure the data 3 times (error ±10), and take the average value. And collect scalp Malassezia samples with a test card, stain them, count the number of Malassezia, and calculate the mean value.

[0042] Test results: As shown in Table 3.

[0043] Table 3

[0044]

[0045]

[0046] Conclusion: It can be seen from the above table that the transepidermal water loss rate of the scalp using the shampoo containing the example decreases significantly, and the skin water retention ability increases, indicating the repair of the skin barrier. The scalp conditioning and repair composition can repair the skin barrier and improve the skin water retention ability. The fluctuation of the scalp sebum growth rate is a stress response during the process of re-establishing balance. After reaching balance, an appropriate amount of scalp sebum is beneficial to maintaining the scalp barrier function and the healthy state of the scalp. Single cleansing shampoo over-cleanses, reducing scalp sebum secretion, which is instead not conducive to the health and stability of the scalp. The colonization and reproduction of microorganisms such as Malassezia can increase the accumulation of lipids in the stratum corneum, damage the lipid tissue structure between the surface cells, cause damage to the scalp barrier, and lead to an increase in dandruff and scalp inflammation. The example significantly reduces the number of Malassezia, indicating that using the shampoo containing the example is beneficial to reducing dandruff and alleviating scalp inflammation.

[0047] Performance Test 2 Chicken Embryo Chorioallantoic Membrane Test

[0048] Referring to the "Chicken Embryo Chorioallantoic Membrane Test Standard for Eye Irritation / Corrosion of Cosmetics" (national standard SN / T 2329-2009) issued by the industry standard of the People's Republic of China's entry-exit inspection and quarantine, the reaction time method is adopted. The chicken embryo chorioallantoic membrane test (HET-CAM) simulates the rabbit eye conjunctiva. Utilizing the characteristics of the intact, clear, and transparent vascular system of the chorioallantoic membrane in the middle stage of the hatched chicken embryo, directly contact 2% dilutions of different test shampoos with the chorioallantoic membrane of the chicken embryo respectively, observe the changes in the toxicity effect indicators of the chorioallantoic membrane (such as bleeding, blood vessel lysis, and blood coagulation) within 5 minutes, record the time when these changes occur, calculate the average value, and then obtain a score according to the calculation formula to evaluate the eye irritation of the test substance. The higher the score, the greater the irritation. See Table 4 for details.

[0049] In each group of this invention, 6 eggs are tested, and a total of 18 groups of tests are conducted.

[0050] Table 4 Result Evaluation of the Stimulation Scoring Method

[0051] Stimulation score Stimulation classification IS < 1 Non-irritating 1 ≤ IS < 5 Slightly irritating 5 ≤ IS < 9 Moderately irritating IS ≥ 9 Strongly irritating

[0052] Bleeding: It refers to the blood flowing out from the blood vessels or capillaries of the chorioallantoic membrane, showing various forms, such as cauliflower-shaped, smooth-shaped, diffuse gauze-shaped or punctate bleeding. Vessel lysis: It refers to the disappearance of blood vessels on the chorioallantoic membrane, which may be caused by multiple factors such as bleeding and changes in the vascular wall tension. Coagulation: It refers to the denaturation of proteins inside and outside blood vessels, usually only seen in large and medium-sized blood vessels, excluding the changes occurring in capillaries. Coagulation can be manifested as the interruption of blood flow inside blood vessels, the appearance of dark coagulation points inside and outside blood vessels, and the turbidity of the chorioallantoic membrane presenting a milky white gauze-like appearance.

[0053] For the test using the reaction time method, the stimulation score (IS) is calculated using Equation (1), and the result is retained to two decimal places:

[0054]

[0055] In the formula: sec H (hemorrhage time) - the average time when bleeding starts to occur observed on the CAM membrane, in seconds (s); sec L (vessel lysis time) - the average time when bleeding starts to occur observed on the CAM membrane, in seconds (s); sec C (coagulation time) - the average time when coagulation starts to appear observed on the CAM membrane, in seconds (s).

[0056] Test results: As shown in Table 5.

[0057] Table 5

[0058]

[0059]

[0060] Conclusion: The shampoo of the example is significantly less irritating than the shampoo of the comparative example, indicating that the scalp conditioning and repair composition can reduce the irritation of surfactants to the scalp.

[0061] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A scalp conditioning and repairing composition, characterized in that, It comprises components in the following parts by weight: 15 - 30 parts of sodium gluconate, 10 - 25 parts of sodium lactate, and 1 - 5 parts of zinc salt; the zinc salt is a mixture of water-soluble zinc salt and fat-soluble zinc salt; the water-soluble zinc salt is a mixture of zinc gluconate and zinc lactate, and the fat-soluble zinc salt is a mixture of zinc palmitate and zinc salicylate; the weight ratio of the water-soluble zinc salt to the fat-soluble zinc salt is (3 - 5):(1 - 2); the weight ratio of zinc gluconate to zinc lactate is 1:(1 - 3); the weight ratio of zinc palmitate to zinc salicylate is 1:(1 - 3).

2. The scalp conditioning and repairing composition according to claim 1, characterized in that The scalp conditioning and repairing composition further comprises 0.1 - 3.5 parts of humectant and 1 - 5 parts of emollient esterifying agent.

3. The scalp conditioning and repair composition according to claim 2, wherein The humectant is at least one of D, L-panthenol and sodium hyaluronate, and the emollient esterifying agent is at least one of caprylic / capric glycerides and hydrogenated polydecene.

4. Use of a scalp conditioning and repairing composition according to any one of claims 1 - 3 in the preparation of a hair care product.

5. A washing and care product, characterized in that, The hair care product is a shampoo, which comprises components in the following parts by weight, with the total parts by weight being 100 parts: 0.05 - 0.3 part of disodium ethylenediaminetetraacetate, 5 - 20 parts of ammonium lauryl ether sulfate, 2 - 10 parts of ammonium lauryl sulfate, 1 - 3 parts of coconut fatty acid monoethanolamide, 0.5 - 1 part of pearlescent flakes, 0.1 - 3 parts of alkyl phthalic amide, 0.1 - 1 part of guar gum, 0.1 - 1 part of allantoin, 1 - 10 parts of cocamidopropyl betaine, 0.1 - 1 part of polyquaternium-22, 0.02 - 1 part of preservative, 2 - 5 parts of dimethicone emulsion, 0.1 - 1 part of sodium chloride, 1 - 15 parts of the scalp conditioning and repairing composition according to claim 2, 0.05 - 0.5 part of essence, and the balance being deionized water.

6. The washing and care product according to claim 5, characterized in that, It comprises components in the following parts by weight, with the total parts by weight being 100 parts: 0.1 part of disodium ethylenediaminetetraacetate, 8 parts of ammonium lauryl ether sulfate, 7 parts of ammonium lauryl sulfate, 1.4 parts of coconut fatty acid monoethanolamide, 0.6 part of pearlescent flakes, 0.5 part of alkyl phthalic amide, 0.25 part of guar gum, 0.2 part of allantoin, 5 parts of cocamidopropyl betaine, 0.6 part of polyquaternium-22, 0.8 part of preservative, 3.3 parts of dimethicone emulsion, 0.3 part of sodium chloride, 5 parts of the scalp conditioning and repairing composition according to claim 2, 0.1 part of essence, and the balance being deionized water.

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