A traditional Chinese medicine exercise stick for preventing trismus and a preparation method thereof

Abstract

This invention relates to traditional Chinese medicine food, specifically to a traditional Chinese medicine exercise stick for preventing difficulty opening the mouth and its preparation method. The exercise stick comprises the following components: 10-30g of Codonopsis pilosula, 15-25g of Scrophularia ningpoensis, 10-25g of Ophiopogon japonicus, 10-20g of Rehmannia glutinosa, 10-20g of Schisandra chinensis, 15-25g of Astragalus membranaceus, 10-15g of Lilium brownii, 5-15g of Glycyrrhiza uralensis, and 60-120g of honey. The preparation method includes the following steps: decoct Codonopsis pilosula, Scrophularia ningpoensis, Ophiopogon japonicus, Rehmannia glutinosa, Schisandra chinensis, Astragalus membranaceus, Lilium brownii, and Glycyrrhiza uralensis twice with water according to the prescribed amounts, filter to obtain the liquid; add honey, mix evenly, and freeze to form the exercise stick. This invention's exercise stick, with its effects of invigorating qi, nourishing yin, and promoting body fluid production, prevents and alleviates tissue restriction, helps patients perform mouth-opening exercises, improves patient compliance, ensures smooth radiotherapy, and improves the quality of life for cancer patients.

Description

Technical Field

[0001] This invention relates to traditional Chinese medicine food products and their preparation methods, and more specifically, to a traditional Chinese medicine exercise stick for preventing difficulty opening the mouth. This invention also relates to a method for preparing this traditional Chinese medicine exercise stick. Background Technology

[0002] Nasopharyngeal carcinoma is one of the most common malignant tumors in my country, and radiotherapy is currently the main treatment for it. With the improvement of cure and survival rates for nasopharyngeal carcinoma, people are increasingly aware of the impact of radiotherapy side effects on patients' quality of life.

[0003] High-dose radiation to the temporomandibular joint can cause reactive exudation and soft tissue adhesions, which can then lead to fibrosis and contractures, restricting temporomandibular joint movement and ultimately causing difficulty opening the mouth, severely impacting the patient's quality of life. Moreover, once difficulty opening the mouth occurs, it is difficult to reverse, and there are no specific treatments available; prevention is the primary focus. Mouth-opening exercises are currently one of the important ways to prevent difficulty opening the mouth after radiotherapy in nasopharyngeal carcinoma patients. However, because nasopharyngeal carcinoma patients often do not pay enough attention to mouth-opening exercises, and the process is often monotonous and uninteresting, patient compliance is low, resulting in unsatisfactory clinical treatment outcomes. Numerous studies have demonstrated a negative correlation between mouth-opening exercises and the severity of difficulty opening the mouth, and these exercises can effectively prevent and treat radiotherapy-related difficulty opening the mouth.

[0004] Simple functional exercises have limited efficacy. Seeking to combine medication and mouth-opening exercise equipment with functional exercises to improve mouth-opening difficulties has become one of the important topics in the rehabilitation of nasopharyngeal carcinoma. At present, there are no effective drugs for treating limited mouth opening at home and abroad. Traditional Chinese medicine has a complete and effective system of diagnosis and treatment for enhancing the efficacy and reducing the toxicity of radiotherapy and chemotherapy, so it is worth exploring. Summary of the Invention

[0005] To address the aforementioned technical problems, the first objective of this invention is to provide a traditional Chinese medicine exercise stick for preventing difficulty in opening the mouth. This exercise stick, with its effects of invigorating qi, nourishing yin, and promoting body fluid production, prevents and reduces tissue restriction, thereby helping patients perform mouth-opening exercises, improving patient compliance, ensuring the smooth progress of radiotherapy, and improving the quality of life for cancer patients.

[0006] The second objective of this invention is to provide a method for preparing a traditional Chinese medicine exercise stick for preventing difficulty in opening the mouth. This method is simple to operate, and the exercise stick prepared is more effective.

[0007] The first objective of this invention is achieved through the following technical solution: a traditional Chinese medicine exercise stick for preventing difficulty in opening the mouth, comprising the following components: 10-30g of Codonopsis pilosula, 15-25g of Scrophularia ningpoensis, 10-25g of Ophiopogon japonicus, 10-20g of Rehmannia glutinosa, 10-20g of Schisandra chinensis, 15-25g of Astragalus membranaceus, 10-15g of Lilium brownii, 5-15g of Glycyrrhiza uralensis, and 60-120g of honey.

[0008] Furthermore, the herbal exercise stick for preventing mouth opening difficulties comprises the following components: 15-20g of Codonopsis pilosula, 20-25g of Scrophularia ningpoensis, 10-20g of Ophiopogon japonicus, 10-15g of Rehmannia glutinosa, 15-20g of Schisandra chinensis, 18-22g of Astragalus membranaceus, 12-15g of Lilium brownii, 5-10g of Glycyrrhiza uralensis, and 80-100g of honey.

[0009] Furthermore, the herbal exercise stick comprises the following components: 20g of Codonopsis pilosula, 20g of Scrophularia ningpoensis, 20g of Ophiopogon japonicus, 15g of Rehmannia glutinosa, 15g of Schisandra chinensis, 20g of Astragalus membranaceus, 15g of Lilium brownii, 10g of Glycyrrhiza uralensis, and 85g of honey.

[0010] The second objective of this invention is achieved through the following technical solution: the preparation method of the above-mentioned traditional Chinese medicine exercise stick includes the following steps:

[0011] (1) According to the prescription, decoct the following herbs twice with water: Codonopsis pilosula, Scrophularia ningpoensis, Ophiopogon japonicus, Rehmannia glutinosa, Schisandra chinensis, Astragalus membranaceus, Lilium brownii and Glycyrrhiza uralensis.

[0012] (2) Filter the two decoctions obtained in step (1), combine the filtrates and continue to boil and concentrate to 300 mL;

[0013] (3) Add honey to the liquid obtained in step (2), mix well and freeze to make a Chinese medicine exercise stick.

[0014] Furthermore, in step (1), the two decoction methods are as follows: the first decoction is made by adding 12 times the amount of water and decocting for 1.5 hours; the second decoction is made by adding 10 times the amount of water and decocting for 1 hour.

[0015] Furthermore, in step (3), honey is added when the liquid temperature drops to 40~50℃.

[0016] Furthermore, in step (3), the radius of the herbal exercise stick is 3.5cm and the height is 4cm.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] 1. The present invention provides a traditional Chinese medicine exercise stick for preventing difficulty in opening the mouth, which has the effects of invigorating qi, nourishing yin and promoting body fluid production, and can prevent and reduce tissue restriction and reduce the side effects caused by radiotherapy.

[0019] 2. The method for preparing the herbal exercise stick of the present invention involves making the herbal medicine into an exercise stick the size of the human mouth to help patients perform mouth-opening exercises, improve patient compliance, ensure the smooth progress of radiotherapy, and improve the quality of life of cancer patients.

[0020] 3. The preparation method of the traditional Chinese medicine exercise stick of the present invention, which involves decocting the raw materials at appropriate time, temperature and method, is more conducive to preserving the medicinal components in the raw materials and the resulting exercise stick has better therapeutic effect.

[0021] In the traditional Chinese medicine exercise stick of the present invention, Pseudostellaria heterophylla replenishes qi, nourishes yin and promotes fluid production, and Scrophularia ningpoensis nourishes yin, increases fluid and dissipates nodules, and they are the monarch drugs together; Schisandra chinensis replenishes qi and promotes fluid production, Ophiopogon japonicus nourishes yin and moistens dryness, and Rehmannia glutinosa nourishes yin and clears heat, and they are all ministerial drugs; Lilium brownii nourishes yin, clears heat and soothes the nerves, and Astragalus membranaceus replenishes qi and consolidates the superficies to expel toxins, and they are both adjuvant drugs; Glycyrrhiza uralensis调和各种药物 and is the guiding drug. At the same time, considering the bitterness of traditional Chinese medicine, honey is used as the excipient of this prescription. Honey has a sweet and neutral flavor and belongs to the lung, spleen, and large intestine meridians, and has the effects of replenishing the middle and moistening dryness, relieving pain and detoxifying. Its pharmacological effects are extensive, and it can promote tissue regeneration, treat wounds, moisten the lungs and relieve cough, antibacterial, antioxidant, laxative, protect the cardiovascular system, anti-tumor, enhance the body's immunity, detoxify, etc. The combination of various drugs has the effects of improving connective tissue hyperplasia and vascular sclerosis, increasing vascular elasticity, and increasing blood supply; reducing platelet aggregation rate and inhibiting thrombus formation; reducing the production of oxygen free radicals, increasing superoxide dismutase, and reducing the content of lipid peroxide, and protecting vascular endothelial cells. Therefore, the present invention has the effects of regulating vasomotor, anti-thrombotic and thrombolytic, anti-free radical damage and protecting vascular endothelial cells, etc., so as to protect against muscle fibrosis and joint sclerosis caused by vascular damage after radiotherapy. In order to better cooperate with the patient for mouth-opening training, the traditional Chinese medicine is made into an exercise stick using a mold of the size of the human oral cavity to assist the patient in opening the mouth. The ice cube can reduce the temperature in the oral cavity and also reduce the sensitivity of the pain nerves of the nerve endings, relieve pain, inhibit the growth and reproduction of bacteria in the oral cavity, and keep the oral cavity clean. Detailed implementation manners

[0022] The following combines with the detailed implementation manners to further elaborate on the technical solutions of the present invention, but does not constitute any limitation to the present invention. Example 1

[0023] Take 20 g of Pseudostellaria heterophylla, 20 g of Scrophularia ningpoensis, 20 g of Ophiopogon japonicus, 15 g of Rehmannia glutinosa, 15 g of Schisandra chinensis, 20 g of Astragalus membranaceus, 15 g of Lilium brownii, and 10 g of Glycyrrhiza uralensis, decoct twice with water. For the first time, add 12 times the amount of water and decoct for 1.5 hours; for the second time, add 10 times the amount of water and decoct for 1 hour. Filter the decoction liquid, combine the two filtrates and continue to decoct and concentrate to 300 mL. When the temperature drops to 40 - 50 °C, add 85 g of honey, stir evenly with a blender and pour it into the ice pop mold ice grid. Each ice grid contains 40 mL of the above-mentioned traditional Chinese medicine liquid, and place it in the freezer to freeze into a traditional Chinese medicine exercise stick with a radius of 3.5 cm and a height of 4 cm. It can also be designed according to the patient's mouth-opening degree and size to suit the patient's size. Example 2

[0024] 10 g of Pseudostellaria heterophylla, 25 g of Scrophularia ningpoensis, 10 g of Ophiopogon japonicus, 20 g of Rehmannia glutinosa, 20 g of Schisandra chinensis, 15 g of Astragalus membranaceus, 10 g of Lilium brownii, 15 g of Glycyrrhiza uralensis and 120 g of honey.

[0025] The preparation method is the same as that of Example 1. Example 3

[0026] 20g of Codonopsis pilosula, 20g of Scrophularia ningpoensis, 10g of Ophiopogon japonicus, 15g of Rehmannia glutinosa, 20g of Schisandra chinensis, 18g of Astragalus membranaceus, 12g of Lilium brownii, 10g of Glycyrrhiza uralensis, and 100g of honey.

[0027] The preparation method is the same as in Example 1.

[0028] Application examples

[0029] A total of 147 patients with head and neck tumors who underwent radiotherapy between February 2022 and February 2024 were selected and randomly divided into an experimental group (n=74) and a control group (n=73) using a random number table. The experimental group consisted of 48 males and 26 females. Both groups received conventional radical radiotherapy. The irradiation range was determined based on clinical signs and CT scan results. 6MV X-ray fractionation using an electron linear accelerator was administered for 7 consecutive weeks, 5 times per week, with a dose of 2 Gy per fraction, for a total dose of 70 Gy. All patients were evaluated before the start of radiotherapy and 3 months after the end of radiotherapy. Patients in the control group received simple mouth-opening exercises, while patients in the experimental group received the traditional Chinese medicine exercise stick prepared in Example 1.

[0030] Comparison of the degree of difficulty in opening the mouth between the two groups of patients after treatment:

[0031] After treatment, there was no statistically significant difference in the incidence of Grade I dysphagia between the two groups (P > 0.05). Grade II dysphagia occurred in 12 patients in the experimental group and 22 in the control group, showing a significant difference in incidence between the two groups (P < 0.05). Grade III dysphagia occurred in 7 patients in the experimental group and 16 in the control group, with the incidence in the experimental group significantly lower than that in the control group (P < 0.05). Only 2 patients in the experimental group developed Grade IV dysphagia, compared to 10 in the control group, showing a significant difference in the incidence of Grade IV dysphagia between the two groups (P < 0.01). Detailed data are shown in Table 1.

[0032]

[0033] Comparison of Head and Neck Tumor Specific Questionnaire (QLQ-H&N35) scores before and after treatment between the two groups of patients

[0034] Before treatment, there was no statistically significant difference in the head and neck tumor-specific questionnaire (QLQ-H&N35) scores between the experimental and control groups (P > 0.05). Although the QLQ-H&N35 scores of both groups were higher 3 months after treatment than before treatment, the experimental group showed significantly lower scores in pain, swallowing, and mouth opening limitation compared to the control group. The experimental group also showed better interpersonal relationships and sexual function compared to the control group. The QLQ-H&N35 scores of the experimental group were significantly lower than those of the control group (P < 0.01). Specific data are shown in Table 2.

[0035]

[0036] Comparison of serum CD62p, IL-6, and IL-8 levels between the two groups of patients before and after treatment

[0037] Before treatment, there were no statistically significant differences in serum CD62p, IL-6, and IL-8 levels between the experimental and control groups (P > 0.05). Three months after treatment, serum CD62p, IL-6, and IL-8 levels in the experimental group were significantly lower than those in the control group (P < 0.05). See Table 3 for specific data.

[0038]

Claims

1. A traditional Chinese medicine exercise stick for preventing difficulty opening the mouth, characterized in that, The medicinal ingredients are: 20g of Codonopsis pilosula, 20g of Scrophularia ningpoensis, 20g of Ophiopogon japonicus, 15g of Rehmannia glutinosa, 15g of Schisandra chinensis, 20g of Astragalus membranaceus, 15g of Lilium brownii, 10g of Glycyrrhiza uralensis, and 85g of honey.

2. The method for preparing the traditional Chinese medicine exercise stick for preventing difficulty opening the mouth as described in claim 1, characterized in that, Includes the following steps: (1) According to the prescription, decoct the following herbs twice with water: Codonopsis pilosula, Scrophularia ningpoensis, Ophiopogon japonicus, Rehmannia glutinosa, Schisandra chinensis, Astragalus membranaceus, Lilium brownii and Glycyrrhiza uralensis. (2) Filter the two decoctions obtained in step (1), combine the filtrates and continue to boil and concentrate to 300 mL; (3) Add honey to the liquid obtained in step (2), mix well and freeze to make a Chinese medicine exercise stick.

3. The method for preparing the traditional Chinese medicine exercise stick for preventing difficulty opening the mouth according to claim 2, characterized in that, In step (1), the two decoction methods are as follows: the first decoction is made by adding 12 times the amount of water and decocting for 1.5 hours; the second decoction is made by adding 10 times the amount of water and decocting for 1 hour.

4. The method for preparing the traditional Chinese medicine exercise stick for preventing difficulty opening the mouth according to claim 2 or 3, characterized in that, In step (3), honey is added when the liquid temperature drops to 40-50°C.

5. The method for preparing the traditional Chinese medicine exercise stick for preventing difficulty opening the mouth according to claim 4, characterized in that, In step (3), the radius of the herbal exercise stick is 3.5cm and the height is 4cm.

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