A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system

Abstract

The present invention discloses a hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system, which relates to the technical field of clinical efficacy monitoring, including a lead detection system outside the hyperbaric oxygen chamber, and an RPPG camera acquisition system inside the hyperbaric oxygen chamber. The probe patch type reflective oximeter of the lead detection system outside the hyperbaric oxygen chamber collects blood oxygen saturation information, and transmits it to a data acquisition and processing module for processing, and the processed blood oxygen saturation information is displayed on a first digital map display system; the RPPG signal acquisition and processing system of the RPPG camera acquisition system in the hyperbaric oxygen chamber receives the LED light reflected back through the skin tissue through a photosensitive sensor, and converts the optical signal into an electrical signal, and then converts it into a digital signal through AD to process and obtain the human body's blood oxygen saturation information, and displays it on a second digital map display system. The present invention can be used for state monitoring and effect evaluation during the treatment of patients in the hyperbaric oxygen chamber, which is convenient for operators to monitor the patient's condition in real time and adjust the treatment plan.

Description

Technical Field

[0001] The present invention relates to the technical field of clinical efficacy monitoring, and in particular to a whole body organ blood oxygen saturation monitoring system in a hyperbaric oxygen chamber. Background Art

[0002] Hyperbaric oxygen therapy is a medical method, also known as oxygen therapy. It allows patients to breathe oxygen in a high-pressure oxygen environment to promote more efficient dissolution of oxygen in the blood, thereby increasing the oxygen supply to body tissues. This treatment method is often used as an auxiliary treatment for some diseases, such as gas poisoning, burns, necrotic skin tissue infection, etc. Hyperbaric oxygen therapy is also used in the treatment of some brain diseases. For example, for diseases such as hypoxic brain damage, encephalitis, and stroke, hyperbaric oxygen therapy can increase the oxygen content in the blood and improve the oxygen supply to brain tissue, thereby reducing hypoxic damage to brain cells and promoting the repair and recovery of brain damage. In addition, hyperbaric oxygen therapy can also reduce cerebral edema, improve cerebral blood flow, etc., which is helpful for the rehabilitation of some brain diseases.

[0003] Blood oxygen saturation is simply the oxygen concentration in the blood. External oxygen enters the human blood through the respiratory system, combines with hemoglobin (HbR) in red blood cells to form oxygenated hemoglobin (HbO2), and is transported to various tissues and organs throughout the body. Blood oxygen saturation is the percentage of oxygenated hemoglobin in the blood that is bound by oxygen to the total hemoglobin capacity that can be bound. It is an important physiological parameter of the respiratory cycle, which reflects the ability of human tissues and organs to obtain sufficient oxygen. Therefore, monitoring arterial oxygen saturation (SaO2) can estimate the oxygenation of the lungs and the oxygen carrying capacity of hemoglobin. The normal human arterial blood oxygen saturation is 98%, and the venous blood is 75%.

[0004] Common oximeters on the market include transmission type and reflection type. The transmission oximeter measurement probe is equipped with two light-emitting diodes: one emits 660nm red light, and the other emits 915nm near-infrared light. When light passes through the body, oxygenated hemoglobin will absorb infrared light, while red light will pass through; deoxygenated hemoglobin will absorb red light, while infrared light will pass through. At the same time, the receiver on the opposite side can receive the penetrated light. By detecting the difference in the absorption of two different wavelengths of light, the measured data difference is the basic data of oxygenated hemoglobin and deoxygenated hemoglobin. Based on these data, blood oxygen saturation can be calculated.

[0005] Transmission oximeters are generally used on fingertips, earlobes, palms, nose wings, etc. The detection of these parts can reflect the changes in arterial blood oxygen saturation throughout the body, but cannot reflect the changes in tissue blood oxygen status due to circulatory disorders in local tissues (such as brain tissue) or large amounts of oxygen consumption in local tissues (such as muscle tissue).

[0006] The design of the reflective oximeter can avoid the disadvantage of the limited penetration depth of the transmission sensor, and is suitable for measuring the oxygen content of local tissues throughout the body. The detection principle of the reflective oximeter is basically the same as that of the transmission oximeter, and the only difference is the sensor. The reflective sensor is also composed of two wavelengths of light-emitting diodes and photosensors, but the photosensors receive the reflected light of the tissue.

[0007] Remote photoplethysmography (RPPG) is a contactless optical technology used to monitor human pulse signals and heart rate signals from a distance. Compared with traditional photoplethysmography (PPG), RPPG does not require direct contact with the skin. Instead, it uses a camera to capture video images of the face or other parts of the subject and extract signals from them. RPPG technology uses a camera to capture tiny color changes on the skin surface, which are caused by the filling and emptying of blood during the heartbeat. By analyzing these color changes in the video image, physiological parameters such as pulse waveform, blood oxygen saturation and heart rate can be obtained. Summary of the invention

[0008] The present invention provides a system for monitoring blood oxygen saturation of whole body organs in a hyperbaric oxygen chamber, which can detect changes in blood oxygen saturation of whole body organs of a patient who enters a hyperbaric oxygen chamber for treatment.

[0009] To achieve the above-mentioned object, the present invention provides a system for monitoring blood oxygen saturation of whole organs in a hyperbaric oxygen chamber, comprising a lead detection system outside the hyperbaric oxygen chamber, a RPPG camera acquisition system inside the hyperbaric oxygen chamber, and a digital map display system respectively connected to the lead detection system outside the hyperbaric oxygen chamber and the RPPG camera acquisition system inside the hyperbaric oxygen chamber;

[0010] The probe patch reflective oximeter of the lead detection system outside the hyperbaric oxygen chamber collects blood oxygen saturation information by directly contacting the human skin. The blood oxygen saturation information is transmitted to the data acquisition and processing module for processing. The processed blood oxygen saturation information is displayed on the digital map display system outside the hyperbaric oxygen chamber.

[0011] The RPPG signal acquisition and processing system of the RPPG camera acquisition system in the hyperbaric oxygen chamber receives the LED light reflected through the skin tissue through a photosensitive sensor, converts the optical signal into an electrical signal, and then converts it into a digital signal through AD to process the human body's blood oxygen saturation information, and displays it on the digital map display system in the hyperbaric oxygen chamber.

[0012] Preferably, the probe patch type reflective oximeter is composed of an LED patch, an integrated signal processing circuit and supporting software; the LED patch is composed of a dual-wavelength LED array and two photodetectors, and the integrated signal processing circuit conditions and outputs the extremely weak electrical signals detected, and after sampling, it is input into the supporting software to complete the final data processing and display.

[0013] Preferably, the LED array uses lasers with excitation wavelengths of 730nm and 850nm as light sources respectively; the LED array is provided with a black silicone surrounding layer.

[0014] Preferably, the integrated signal processing circuit includes a voltage-current conversion module, a signal amplification module, and a filtering module; the signal amplification module includes a pre-stage amplification module and a post-stage amplification module;

[0015] The photoelectric signal output by the photodetector is amplified by the pre-amplifier module and then filtered out by the filter module to remove high-frequency noise to obtain a pure low-frequency signal carrying blood oxygen saturation information. The low-frequency signal is further amplified by the post-amplifier module and then transmitted to the microcontroller for digital processing.

[0016] Preferably, the single chip microcomputer is responsible for AD sampling and converting into digital signals, and communicating with the supporting software system to realize the transmission of signal data.

[0017] Preferably, the supporting software system includes a communication module, a data processing module, and a waveform display module. The supporting software system communicates with the single-chip computer to complete data reception; the data processing module calculates the absorption coefficient of reduced hemoglobin and oxygenated hemoglobin according to the Lambert-Beer law to obtain the local hemoglobin oxygen saturation;

[0018] The hemoglobin oxygen saturation information is transmitted to a digital map display system outside the hyperbaric oxygen chamber, which displays the blood oxygen saturation information of the brain, kidneys, intestines, hands, and legs as well as the heart rate and blood pressure information.

[0019] Preferably, the RPPG signal acquisition and processing system comprises two light emitting diodes with different peak emission wavelengths and a photosensitive sensor, wherein the peak emission wavelengths of the two light emitting diodes are 660nm red and 940nm infrared, respectively;

[0020] The photosensor receives the reflected LED light intensity from oxygenated hemoglobin and reduced hemoglobin to extract the PPG signal of each wavelength. The corresponding blood oxygen saturation can be obtained according to the following formula:

[0021]

[0022] Among them, R and IR represent red light and infrared light respectively, and L and H represent the valley and peak value of the signal respectively.

[0023] Preferably, the blood oxygen saturation information is processed by a digital map display system in the hyperbaric oxygen chamber and displayed as blood oxygen saturation information including the brain, intestines, hands, and legs, as well as heart rate and blood pressure information.

[0024] When light passes through skin tissue and then reflects to the photosensor, the light will be attenuated to a certain extent. The absorption of light by muscles, bones, veins and other connecting tissues is basically unchanged, but blood is different. Since blood flows in the arteries, the absorption of light naturally changes. When light is converted into electrical signals, the signals obtained can be divided into direct current (DC) signals and alternating current (AC) signals, precisely because the absorption of light by arteries changes while the absorption of light by other tissues remains basically unchanged. Extracting the AC signal can reflect the characteristics of blood flow. This technology is called PPG.

[0025] Traditional PPG technology often requires close contact with the skin and has a narrow application range, so a large number of studies have begun to focus on remotely detecting human body information through cameras. The principle behind it is called RPPG. The blood flow caused by each heartbeat will form periodic changes in the microvessels of human skin tissue, which will also produce a periodic signal for the absorption or reflection of light. This periodic signal cannot be observed by the human eye, but it can be analyzed from the facial data collected by the high-definition camera, so it can be used to detect many physiological indicators of the human body, such as heart rate variability, respiratory rate, blood oxygen saturation, etc.

[0026] The present invention provides a system for monitoring blood oxygen saturation of whole body organs in a hyperbaric oxygen chamber, which has the following beneficial effects:

[0027] (1) It can realize instantaneous monitoring of the blood oxygen saturation of various organs of the patient's body when the patient starts hyperbaric oxygen chamber treatment and when the patient ends hyperbaric oxygen chamber treatment, or real-time monitoring of the blood oxygen saturation of various organs of the patient's body during hyperbaric oxygen chamber treatment;

[0028] (2) The relevant data of the patient's whole body organ blood oxygen saturation are collected and processed, output and displayed as a visual digital map, which can more clearly understand the impact of hyperbaric oxygen therapy on various parts of the patient's body and more specifically analyze and evaluate the effect of hyperbaric oxygen therapy.

[0029] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is an overall system design diagram of a system for monitoring blood oxygen saturation of whole body organs in a hyperbaric oxygen chamber according to the present invention;

[0031] Figure 2 It is a schematic diagram of the lead detection and digital map display system outside the hyperbaric oxygen chamber;

[0032] Figure 3 This is a schematic diagram of the RPPG video acquisition and digital map display system in the hyperbaric oxygen chamber;

[0033] Figure 4 This is a schematic diagram of the display content of the digital map display system outside the hyperbaric oxygen chamber;

[0034] Figure 5 This is a schematic diagram of the display content of the digital map display system in the hyperbaric oxygen chamber. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical scheme and advantages disclosed in the embodiments of the present invention clearer, the embodiments of the present invention are further described in detail in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the embodiments of the present invention and are not intended to limit the embodiments of the present invention. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application. Examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions.

[0036] It should be noted that the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or server that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units that are not explicitly listed or inherent to these processes, methods, products or devices.

[0037] Like reference numerals and letters denote similar items in the following drawings, and thus, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0038] Embodiment 1

[0039] A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system, the overall system design is as follows Figure 1 As shown, it mainly includes the lead detection and digital map display system outside the hyperbaric oxygen chamber ( Figure 2 ), RPPG video acquisition and digital map display system in the hyperbaric oxygen chamber ( Figure 3 ) two parts.

[0040] The lead detection and digital map display system outside the hyperbaric oxygen chamber includes a probe patch reflective oximeter, a data acquisition and processing module, and a digital map display system. The probe patch reflective oximeter collects blood oxygen saturation information by directly contacting the human skin, and then transmits the relevant data to the data acquisition and processing module for processing, and finally displays it on the digital map display system.

[0041] The RPPG video acquisition and digital map display system in the hyperbaric oxygen chamber includes the RPPG signal acquisition and processing system and the digital map display system. The RPPG signal acquisition and processing system is to emit LED light to the skin, and then use the photosensitive sensor to receive the light reflected through the skin tissue and convert it into an electrical signal, and then convert it into a digital signal through AD, and further process the human body's blood oxygen saturation information and display it on the digital map display system.

[0042] Embodiment 2

[0043] The lead detection and digital map display system outside the hyperbaric oxygen chamber includes a probe patch type reflective oximeter, a data acquisition and processing module, and a digital map display system.

[0044] The probe patch reflective oximeter consists of an LED patch, an integrated signal processing circuit and supporting software. The LED patch consists of a dual-wavelength LED array and two photodetectors. The integrated signal processing circuit conditions and outputs the extremely weak electrical signals detected, and after sampling, it is input into the supporting software to complete the final data processing and display.

[0045] The absorption coefficients of oxygenated hemoglobin and reduced hemoglobin in the blood for light of different wavelengths are different. For red light with a wavelength of 600-700nm, the absorption coefficient of reduced hemoglobin is larger than that of oxygenated hemoglobin; and for near-infrared light with a wavelength of 800-1000nm, the absorption coefficient of oxygenated hemoglobin is larger than that of reduced hemoglobin.

[0046] The probe patch reflective oximeter monitors blood oxygen saturation based on the different absorption characteristics of oxygenated hemoglobin and reduced hemoglobin in the red light and near-infrared light bands. According to the timing of LED light emission, the brain blood oxygen saturation information carried by each wavelength in each brain blood oxygen channel is separated, and the blood oxygen saturation is calculated in combination with the Lambert-Beer law.

[0047] The LED light-emitting diodes use lasers with excitation wavelengths of 730nm and 850nm as light sources. When the device is working, the probe needs to fit closely to the human skin, so a photodiode with good stability and strong impact resistance is required. Considering that the monitoring signal is extremely weak, a black silicone surrounding layer is provided to effectively isolate ambient light interference.

[0048] The integrated signal processing circuit consists of a voltage-current conversion module, a signal amplification module, and a filtering module. The photoelectric signal output by the photodetector is first amplified in the pre-stage, and then the high-frequency noise is filtered out to obtain a pure low-frequency signal carrying blood oxygen saturation information. After further amplification by the post-stage amplifier module, the signal is transmitted to the microcontroller for digital processing.

[0049] The single chip microcomputer is responsible for AD sampling and converting it into digital signals, and communicating with the supporting software system to realize the transmission of signal data.

[0050] The supporting software system consists of a communication module, a data processing module, and a waveform display module, which communicates with the single-chip microcomputer on the hardware circuit to complete the data reception. In order to ensure the stability of the data and remove the influence of singular values, multiple sets of data are collected and the maximum and minimum values ​​are removed to calculate the mean value. Finally, the absorption coefficients of reduced hemoglobin and oxygenated hemoglobin are calculated based on the Lambert-Beer law, and then the absorption spectrum ratio is calculated to obtain the local hemoglobin oxygen saturation.

[0051] Finally, the blood oxygen saturation information is processed by the digital map display system and displayed as follows: Figure 4 It includes blood oxygen saturation information of the brain, kidneys, intestines, hands, legs, as well as heart rate and blood pressure information.

[0052] Embodiment 3

[0053] The RPPG video acquisition and digital map display system in the hyperbaric oxygen chamber includes an RPPG signal acquisition and processing system and a digital map display system.

[0054] The RPPG signal acquisition and processing system is composed of two light-emitting diodes with different peak emission wavelengths (660nm red and 940nm infrared) and a photosensitive sensor. When the light from the light-emitting diode passes through the artery, the light intensity received by the photosensitive element is different due to the different absorption rates of oxygenated hemoglobin and reduced hemoglobin for light of different wavelengths. And the light intensity received by the photosensitive element contains PPG information at each wavelength, which is the absorption rate modulation caused by the peripheral arterial pressure wave form.

[0055] By extracting the PPG signal for each wavelength and comparing the ratio, peak and valley values ​​of each PPG and the logarithm of the corresponding pulse, a variable called ratio can be generated:

[0056]

[0057] Among them, R and IR represent red light and infrared light respectively, and L and H represent the valley value and peak value of the signal respectively. Therefore, the corresponding blood oxygen saturation can be calculated through this ratio.

[0058] Finally, the blood oxygen saturation information is processed by the digital map display system and displayed as follows: Figure 5 As shown, it includes blood oxygen saturation information of the brain, intestines, hands, and legs, as well as heart rate and blood pressure information.

[0059] The hyperbaric oxygen chamber whole-body organ blood oxygen saturation monitoring system proposed in the present invention can more accurately and extensively reflect the blood oxygen saturation of various parts and organs of the whole body of the patient during the hyperbaric oxygen chamber treatment. Compared with the current situation that traditional blood gas analysis equipment can only target a single part, the present invention provides data from multiple parts, which can reflect and compare the changes in blood oxygen saturation of various organs in the whole body from multiple aspects, and further reflect the effect of hyperbaric oxygen chamber treatment of diseases.

[0060] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solution of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the present invention.

Claims

1. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system, characterized by: It includes a lead detection system outside the hyperbaric oxygen chamber, an RPPG video acquisition system inside the hyperbaric oxygen chamber, and a digital map display system respectively connected to the lead detection system outside the hyperbaric oxygen chamber and the RPPG video acquisition system inside the hyperbaric oxygen chamber; The probe patch reflective oximeter of the lead detection system outside the hyperbaric oxygen chamber collects blood oxygen saturation information by directly contacting the human skin. The blood oxygen saturation information is transmitted to the data acquisition and processing module for processing. The processed blood oxygen saturation information is displayed on the digital map display system outside the hyperbaric oxygen chamber. The digital map display system outside the hyperbaric oxygen chamber displays the blood oxygen saturation information of the brain, kidneys, intestines, hands, and legs, as well as the heart rate and blood pressure information. The RPPG signal acquisition and processing system of the RPPG camera acquisition system in the hyperbaric oxygen chamber receives the LED light reflected back through the skin tissue through the photosensitive sensor, and converts the optical signal into an electrical signal, which is then converted into a digital signal through AD processing to obtain the blood oxygen saturation information of the human body, and is displayed on the digital map display system in the hyperbaric oxygen chamber; The RPPG signal acquisition and processing system includes two light-emitting diodes with different peak emission wavelengths and a photosensitive sensor. The peak emission wavelengths of the two light-emitting diodes are 660nm red and 940nm infrared respectively. The photosensor receives the LED light intensity reflected from oxygenated hemoglobin and reduced hemoglobin to extract the PPG signal of each wavelength. The corresponding blood oxygen saturation can be obtained according to the following formula: Among them, R and IR represent red light and infrared light respectively, L and H represent the valley and peak value of the signal respectively; The blood oxygen saturation information is processed by the digital map display system in the hyperbaric oxygen chamber and displayed as blood oxygen saturation information including the brain, intestines, hands, legs, heart rate, and blood pressure information.

2. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system according to claim 1, characterized in that: The probe patch type reflective oximeter consists of an LED patch, an integrated signal processing circuit and supporting software; the LED patch consists of a dual-wavelength LED array and two photodetectors, and the integrated signal processing circuit conditions and outputs the extremely weak electrical signals detected, and after sampling, it is input into the supporting software to complete the final data processing and display.

3. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system according to claim 2, characterized in that: The LED array uses lasers with excitation wavelengths of 730nm and 850nm as light sources respectively; the LED array is equipped with a black silicone surrounding layer.

4. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system according to claim 2, characterized in that: The integrated signal processing circuit includes a voltage-current conversion module, a signal amplification module, and a filtering module; the signal amplification module includes a pre-stage amplification module and a post-stage amplification module; The photoelectric signal output by the photodetector is amplified by the pre-amplifier module and then filtered out by the filter module to remove high-frequency noise to obtain a pure low-frequency signal carrying blood oxygen saturation information. The low-frequency signal is further amplified by the post-amplifier module and then transmitted to the microcontroller for digital processing.

5. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system according to claim 4, characterized in that: The single chip microcomputer is responsible for AD sampling and converting it into digital signals, and communicating with the supporting software system to realize the transmission of signal data.

6. A hyperbaric oxygen chamber whole body organ blood oxygen saturation monitoring system according to claim 2 or 4, characterized in that: The supporting software system includes a communication module, a data processing module, and a waveform display module. The supporting software system communicates with the single-chip microcomputer to complete data reception; the data processing module calculates the absorption coefficients of reduced hemoglobin and oxygenated hemoglobin according to the Lambert-Beer law to obtain the local hemoglobin oxygen saturation; Hemoglobin oxygen saturation information is transmitted to a digital map display system outside the hyperbaric oxygen chamber.

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