New applications of Lactobacillus delbrueckii surface proteins

By preparing the surface protein of Lactobacillus delbrueckii, the quality and safety issues of probiotics in the prevention and treatment of intestinal inflammation were solved, and effective relief of intestinal inflammation, especially the treatment of ulcerative colitis, was achieved.

CN118530316BActive Publication Date: 2025-09-16CHINA AGRI UNIV
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Patent Information

Application Number
CN202410604258.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-05-15
Publication Date
2025-09-16
Estimated Expiration
2044-05-15

AI Technical Summary

Technical Problem

Currently, there are problems with the use of probiotics in the prevention and treatment of intestinal inflammation, such as difficulty in ensuring the quality of the agents, dependence of their effectiveness on the number of live bacteria, and potential for causing adverse reactions. The function of the surface protein of Lactobacillus delbrueckii has not yet been fully explored.

Method used

The surface protein of Lactobacillus delbrueckii is extracted and processed through fermentation, incubation with lithium chloride solution, dialysis and filtration to prepare a Lactobacillus delbrueckii surface protein solution for use in the preparation of products for improving intestinal inflammation.

Benefits of technology

The surface protein of Lactobacillus delbrueckii can alleviate DSS-induced ulcerative colitis in mice, improve weight loss, shortened colon length and colon mucosal damage, reduce the content of pro-inflammatory cytokines, increase the content of anti-inflammatory cytokines, regulate macrophage phenotype, and have a good anti-inflammatory effect.

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Abstract

The present invention belongs to the field of biomedicine technology, and specifically discloses the application of Lactobacillus delbrueckii surface protein in the preparation of products that improve intestinal inflammation. The new use of Lactobacillus delbrueckii surface protein provided by the present invention, including the application in the preparation of a medicine for preventing and / or treating ulcerative colitis. Cell and animal experimental results show that Lactobacillus delbrueckii surface protein can alleviate DSS-induced ulcerative colitis in mice, improve weight loss, shortened colon length and colon mucosal damage, reduce proinflammatory cytokine (such as IL-1β, IL-6) content in the colon, increase anti-inflammatory cytokine (such as IL-10) content, reduce proinflammatory macrophage ratio in spleen and colon, inhibit macrophage proinflammatory phenotype, can be used for the preparation of products that improve intestinal inflammation, and has good application prospects and potential clinical treatment value.
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