An Ankang medicinal decoction for treating ulcerative colitis

Abstract

The present invention relates to the technical field of traditional Chinese medicine, specifically a kind of Ankang medicine soup for treating ulcer, which includes the following raw materials by weight: 1-5 parts of ginseng, 10-20 parts of psoralea corylifolia, 3-8 parts of evodia rutaecarpa, 1-5 parts of nutmeg, 5-15 parts of gardenia, 5-15 parts of lophatherum gracile, 10-20 parts of talc, 10-15 parts of schisandra chinensis, 10-20 parts of patrinia scabra, 3-8 parts of chicken's gizzard lining, 5-15 parts of scutellaria baicalensis, 5-15 parts of capillaris, 1-5 parts of earthworm, and 1-5 parts of indigo. The present invention has a quick effect, and after taking the medicine, the symptoms of blood in the stool can be reduced; the number of daily stools returns to normal, the viscosity is normal, the cure is thorough, and no recurrence occurs; the side effect is small; after the cure, there are no other sequelae.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicines, in particular to a kind of Ankang medicinal soup for treating ulcer. Background Art

[0002] Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease with an unknown cause, which is caused by environmental and genetic factors. The disease mostly occurs in the rectum, left colon and entire colon. The disease is more common in young and middle-aged people. The prevalence of UC in my country is as high as 11.6 / 100,000, and the prevalence is increasing year by year. Its clinical symptoms mainly include abdominal pain, diarrhea, and mucus, pus and blood in the stool. It is a common and difficult disease among digestive system diseases. The clinical symptoms are also accompanied by fever, as well as lesions of organs such as eyes and joints. Severe cases are accompanied by intestinal perforation and malignant transformation, which have a serious impact on the patient's physical and mental health.

[0003] Currently, Western medicine treatment of UC mainly focuses on relieving clinical symptoms, anti-inflammation, protecting damaged mucosa, promoting ulcer healing and reducing complications. The main clinical treatment drugs and methods include antibiotics, immunosuppressants, glucocorticoids and fecal microbiota transplantation, but long-term drug treatment will produce great side effects, damage liver and kidney function, and patients have poor treatment compliance, which brings great challenges to clinical treatment.

[0004] At present, the clinical treatment for UC mainly focuses on relieving the patient's clinical symptoms, anti-inflammation, protecting damaged mucosa, promoting ulcer healing and preventing complications. Currently commonly used drugs can effectively relieve the symptoms of UC attacks, but they cause varying degrees of damage to the liver and kidneys.

[0005] Therefore, people have a strong demand for traditional Chinese medicine and Chinese patent medicine that can treat both the symptoms and the root cause, are easy to take, safe and have no toxic side effects. It is very meaningful and necessary to develop traditional Chinese medicine preparations for the treatment of this disease. Summary of the invention

[0006] The purpose of the present invention is to provide a kind of Ankang medicine soup for treating ulcer, so as to solve the problems of poor curative effect, slow ulcer healing and great side effects existing in the prior art.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] A kind of health medicine soup for treating ulcer, the Chinese medicine comprises the following raw materials by weight:

[0009] 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra fruit, 5 - 20 parts of patrinia herb, 3 - 8 parts of chicken gizzard-membrane, 5 - 15 parts of scutellaria root, 5 - 15 parts of virgate wormwood herb, 1 - 5 parts of earthworm, 1 - 10 parts of indigo naturalis.

[0010] Preferably, by weight parts, the traditional Chinese medicine comprises the following raw materials: 2 - 4 parts of ginseng, 12 - 18 parts of psoralea fruit, 4 - 6 parts of evodia fruit, 2 - 4 parts of nutmeg, 8 - 12 parts of gardenia fruit, 8 - 12 parts of lophatherum herb, 12 - 18 parts of talc, 12 - 18 parts of schisandra fruit, 12 - 18 parts of patrinia herb, 4 - 6 parts of chicken gizzard-membrane, 8 - 12 parts of scutellaria root, 8 - 12 parts of virgate wormwood herb, 2 - 4 parts of earthworm, 2 - 4 parts of indigo naturalis.

[0011] Preferably, by weight parts, the traditional Chinese medicine comprises the following raw materials: 3 parts of ginseng, 15 parts of psoralea fruit, 5 parts of evodia fruit, 3 parts of nutmeg, 10 parts of gardenia fruit, 10 parts of lophatherum herb, 15 parts of talc, 10 parts of schisandra fruit, 15 parts of patrinia herb, 5 parts of chicken gizzard-membrane, 10 parts of scutellaria root, 10 parts of virgate wormwood herb, 3 parts of earthworm, 3 parts of indigo naturalis.

[0012] Preferably, for patients with heavier mucus, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra fruit, 10 - 20 parts of patrinia herb, 3 - 8 parts of chicken gizzard-membrane, 5 - 15 parts of scutellaria root, 5 - 15 parts of virgate wormwood herb, 1 - 5 parts of earthworm, 1 - 5 parts of indigo naturalis, 3 - 8 parts of pulsatilla root.

[0013] Preferably, for patients with heavier abdominal pain, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra fruit, 10 - 20 parts of patrinia herb, 3 - 8 parts of chicken gizzard-membrane, 5 - 15 parts of scutellaria root, 5 - 15 parts of virgate wormwood herb, 1 - 5 parts of earthworm, 5 - 10 parts of indigo naturalis, 3 - 8 parts of coptis root.

[0014] Preferably, for patients with heavier diarrhea, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra fruit, 5 - 10 parts of patrinia herb, 3 - 8 parts of chicken gizzard-membrane, 5 - 15 parts of scutellaria root, 5 - 15 parts of virgate wormwood herb, 1 - 5 parts of earthworm, 1 - 5 parts of indigo naturalis, 8 - 15 parts of granatum peel.

[0015] Preferably, for patients with severe abdominal distension, the Chinese medicine includes the following raw materials, by weight: 1-5 parts of ginseng, 10-20 parts of psoralea corylifolia, 3-8 parts of Evodia rutaecarpa, 1-5 parts of nutmeg, 5-15 parts of Gardenia jasminoides, 5-15 parts of Lophatherum gracile, 10-20 parts of talc, 10-15 parts of Schisandra chinensis, 10-20 parts of Patrinia scabra, 3-8 parts of chicken gizzard lining, 5-15 parts of Scutellaria baicalensis, 5-15 parts of Artemisia capillaris, 1-5 parts of Pheretima wormwood, 1-5 parts of Indigo naturalis, and 3-8 parts of Citrus aurantium (use with caution in pregnant women).

[0016] The invention discloses a method for decocting a healthy medicinal soup for treating ulcer. The method comprises the following steps: dividing a portion of the medicine into three portions, placing one portion into a decocting container, adding clear water to submerge all the medicine, using high heat and then switching to low heat, decocting for 15-20 minutes, placing the poured medicinal soup in a container and letting it cool, repeating the process twice, and taking the medicinal soup orally three times within one day.

[0017] The pharmacological analysis of the present invention is as follows:

[0018] (1) Ginseng: Ginseng is a traditional Chinese medicine that is a tonic. It is the dried root and rhizome of the Araliaceae plant. It has the effects of replenishing vital energy, restoring the pulse and strengthening the body, nourishing the spleen and lungs, promoting the production of body fluids and nourishing blood, and calming the mind and improving intelligence. Ginseng juice, leaves, and powder can promote the rapid healing of wounds and ulcers. Ginseng can enhance the body's resistance to cancer cells, improve the patient's physical condition, prevent cancer cell metastasis, and delay tumor growth and the expansion of cancer lesions.

[0019] (2) Psoralea corylifolia: It is an annual herbaceous plant of the genus Psoraleae in the leguminous family. It warms the kidney and boosts yang, consolidates semen and reduces urination, promotes qi and relieves asthma, warms the spleen and stops diarrhea. It contains chemical ingredients such as flavonoids, coumarins, and monoterpene phenols, and has anti-implantation, immunity-enhancing, hemostatic, and anti-cancer effects.

[0020] (3) Evodia rutaecarpa: It is a plant of the Rutaceae family and the genus Evodia. It has the effects of dispelling cold and relieving pain, relieving adverse reactions and stopping vomiting, promoting yang and stopping diarrhea, and warming the interior. Evodia rutaecarpa has multiple pharmacological effects, such as inhibiting gastrointestinal motility, anti-ulcer, anti-diarrhea, anti-inflammatory, analgesic, anti-tumor, anti-platelet aggregation, anti-thrombotic, cardiotonic, anti-myocardial ischemia, and lowering blood pressure.

[0021] (4) Nutmeg: an evergreen tree of the genus Myristica in the family Myristicaceae. It is pungent in taste and warm in nature. It has the effects of astringing the intestines and stopping diarrhea, warming the middle and promoting the flow of qi. It is mainly used to treat chronic diarrhea, cold pain in the abdomen, etc. It warms the middle and promotes the flow of qi, astringes the intestines and stops diarrhea, and is an astringent drug. Nutmeg has multiple pharmacological effects such as antidiarrhea, anti-inflammatory, analgesic, antibacterial, appetite-promoting, sedative, and anti-tumor, and helps to astringe and warm the intestines.

[0022] (5)Gardenia Fruit: The dried ripe fruit of the plant Gardenia jasminoides Ellis, which can purge fire and remove vexation, clear heat and promote diuresis, cool blood and detoxify. Gardenia fruit has various pharmacological effects such as hypoglycemic, anti-atherosclerotic, antidepressant, hepatoprotective and cholagogic, anti-tumor, antibacterial, and neuroprotective effects. It has the effects of protecting the liver, promoting bile flow, lowering blood pressure, sedation, hemostasis, and detumescence. It is commonly used in traditional Chinese medicine clinics to treat jaundice hepatitis, contusions and strains, hypertension, diabetes, etc.

[0023] (6)Lophatherum gracile: A perennial herb of the family Poaceae and the genus Lophatherum. It can clear heat and purge fire, remove vexation and quench thirst, induce diuresis and relieve stranguria. It belongs to heat-clearing drugs and has various pharmacological effects such as antipyretic, diuretic, anti-tumor, antibacterial, and blood sugar-elevating effects. Bamboo leaves contain a large amount of flavonoid compounds, bioactive polysaccharides and other active ingredients, such as phenolic acid compounds, anthraquinone compounds, terpene lactones, special amino acids and active peptides, and trace elements such as manganese, zinc, and selenium. The functional factors contained in bamboo leaves are mainly flavonoid glycosides and coumarin lactones. The content and biological activity of its active ingredients are comparable to those of Ginkgo biloba leaves. Bamboo leaf extract has excellent anti-free radical, antioxidant, anti-aging, lipid-lowering and blood cholesterol-lowering effects.

[0024] (7)Talc: Antibacterial, protect skin and mucous membranes, diuretic. Talc is a hydrothermal alteration mineral and a common silicate mineral. Talc medicinal materials are in the shape of flat, rhomboid or irregular blocks, with different sizes. The whole body is white, egg blue or yellowish white, with a pearly luster on the surface, semi-transparent or opaque. It is soft and delicate, with a smooth feeling when touched by hand, and white powder can be scraped off with a finger. It is odorless, tasteless, and has a slightly cool feeling. It has the effects of antibacterial, protecting skin and mucous membranes, and diuretic. Antibacterial: Talc has a certain inhibitory effect on Salmonella typhi and Salmonella paratyphi. Therefore, when talc is added as an additive to drugs, it can also play a role in sterilization and anti-inflammatory. Protect skin and mucous membranes. Due to the small particle size and large total area of talc powder, it can adsorb a large amount of chemical irritants or poisons. Therefore, when sprinkled on the surface of inflamed or damaged tissues, it can have a protective effect. When taken orally, in addition to protecting the inflamed gastrointestinal mucosa and playing an antiemetic and antidiarrheal role, it can also prevent the absorption of poisons in the gastrointestinal tract. It has the effect of promoting diuresis and detumescence. For patients with dysuria or pain during urination, combining talc powder with Plantago asiatica and Akebia quinata has the effect of inducing diuresis and relieving stranguria.

[0025] (8)Schisandra chinensis: The dried ripe fruit of the plant Schisandra chinensis (Turcz.) Baill. of the family Magnoliaceae. The medicinal properties of Schisandra chinensis are sour, sweet, and warm, and it belongs to the lung, heart, and kidney meridians. Schisandra chinensis is sour, astringent, moistening, and warm-tonifying, combining astringency and supplementation, entering the lung, kidney, and heart meridians. It can astringe the lung to arrest cough and asthma, nourish the kidney to astringe essence and stop diarrhea, generate body fluid internally to soothe the mind and calm the nerves, and astringe the exterior to stop sweating. It has all five flavors, with sourness being the most prominent; although it is warm in nature, it is moistening in quality; combining astringency and supplementation, reducing expenditure and increasing supply. Its medicinal power is relatively strong, and it is an important medicine for tonifying deficiency, strengthening the body, and astringing. It contains lignan components, volatile oils, and also contains polysaccharides, amino acids and other components. It has the functions of astringing and consolidating, replenishing qi and generating body fluid, and tonifying the kidney and soothing the mind.

[0026] (9)Patrinia Scabiosaefolia: It belongs to the plants of the Valerianaceae family. Its medicinal properties are bitter and cold. It is an essential medicine for clinically treating abdominal pain due to intestinal abscess, with the functions of clearing heat and detoxifying, dispelling carbuncles and discharging pus, and is a kind of heat-clearing medicine. Modern pharmacological research has found that its chemical components are mainly Patrinia scabiosaefolia and various saponins. Patrinia Scabiosaefolia has a significant inhibitory effect on various types of bacteria; it also has a certain anti-tumor effect. It is the dried whole herb of the Patrinia villosa Juss. of the Valerianaceae family. It is cool in nature, pungent and bitter in taste. It has the effects of clearing heat and detoxifying, removing phlegm and discharging pus, and is commonly used for intestinal abscess, lung abscess, dysentery, postpartum blood stasis abdominal pain, carbuncles and furuncles.

[0027] (10)Endothelium Corneum Gigeriae Galli: Endothelium Corneum Gigeriae Galli tastes sweet and neutral, and enters the spleen, stomach, small intestine, and bladder meridians. Endothelium Corneum Gigeriae Galli is beneficial to the middle energizer with a neutral nature and no bias. It has the functions of grinding and astringing, and its medicinal power is relatively strong. Entering the spleen and stomach meridians, it is good at promoting the function of the spleen and strengthening the stomach, promoting digestion and resolving food stagnation, and is an essential medicine for promoting digestion and activating the spleen. Entering the small intestine and bladder meridians, it can not only resolve hard masses and promote digestion but also consolidate essence and stop involuntary ejaculation, and can be used to treat stones, enuresis, and spermatorrhea. The traditional Chinese medicine Endothelium Corneum Gigeriae Galli mainly contains gastric juice (gastrin), keratin, pepsin, amylase, various vitamins, lysine, serine and other 18 kinds of amino acids, as well as trace elements such as aluminum, calcium, chromium, cobalt, copper, and iron. It has the effects of promoting digestion and strengthening the stomach, astringing essence and stopping involuntary ejaculation, and removing calculi and promoting diuresis.

[0028] (11)Scutellaria baicalensis: Scutellaria baicalensis belongs to the leguminous plants and is a perennial tall herb. It has the functions of clearing heat and drying dampness, purging fire and detoxifying, and stopping bleeding. The medicinal properties of Scutellaria baicalensis are bitter and cold. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Scutellaria baicalensis is bitter, cold, clear, and drying. It mainly enters the lung and large intestine meridians, and also enters the gallbladder, spleen, and stomach meridians. It can not only clear heat and purge fire, cool the blood and stop bleeding, prevent miscarriage, and relieve heat toxin, but also dry dampness, remove dampness, and relieve damp-heat toxin. It is an essential medicine for treating damp-heat fire toxin and is widely used in the diseases of damp-heat fire toxin. Compared with Coptis chinensis, its ability to clear heat and dry dampness is weaker, and its action is biased towards the upper jiao lung and large intestine. It is good at clearing upper jiao damp-heat and removing the fire of the lung and large intestine. This product contains flavonoid components such as baicalin, baicalein (baicalin aglycone), wogonin, wogonoside, and baicalein new. In addition, it also contains volatile oil components such as acetophenone, palmitic acid, and oleic acid, sitosterol, baicalin enzyme and other components, and has the functions of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and preventing miscarriage. Scutellaria baicalensis contains components such as polysaccharides, saponins, flavonoids, and amino acids. Among them, the effective component for treating UC is mainly Scutellaria baicalensis polysaccharide, which has the effects of relieving inflammation, sterilizing, enhancing immunity, and antioxidant.

[0029] (12)Artemisia capillaris: Artemisia capillaris can clear and promote dampness, promote bile flow and reduce jaundice. The medicinal properties of Artemisia capillaris are bitter, pungent, and slightly cold. It enters the spleen, stomach, liver, and gallbladder meridians. Artemisia capillaris is bitter, slightly cold, clear and promoting, with a fragrant smell and dredging function. It enters the spleen, stomach, liver, and gallbladder meridians. It is good at clearing and promoting dampness and reducing jaundice, and is an essential medicine for treating jaundice, suitable for both yang jaundice and yin jaundice. It can also relieve itching and is used to treat wet sores and eczema itching.

[0030] (13)Earthworm: It can clear heat and calm endogenous wind, dredge collaterals, relieve asthma. Earthworm was first recorded in "Shennong Ben Cao Jing" and classified as a lower-grade herb. Earthworm tastes salty and is cold in nature, and belongs to the liver, spleen, and bladder meridians. Entering the liver meridian, it can clear heat and calm endogenous wind to stop convulsions; entering the lung meridian, it can clear the lung and drain heat to relieve asthma; entering the bladder meridian, it can promote diuresis and relieve stranguria; walking along the meridians, it can dredge collaterals and treat tinea. It has the effects of clearing heat and calming endogenous wind, dredging collaterals, relieving asthma, and promoting diuresis, and is commonly used for high fever with coma, infantile convulsions, arthralgia due to wind-dampness, limb numbness, hemiplegia, cough and asthma due to lung heat, and oliguria with edema. Earthworm has pharmacological effects such as antipyretic, sedative, anticonvulsant, antithrombotic, antihypertensive, anti-inflammatory, analgesic, anti-asthmatic, and enhancing immunity.

[0031] (14)Indigo Naturalis is the dry mass or powder obtained by processing the leaves or stems and leaves of Baphicacanthus cusia (Nees) Bremek., Polygonum tinctorium Lour., or Isatis indigotica Fort.. Indigo Naturalis can play a certain role in pharmacological effects such as anti-inflammatory, antibacterial, immunomodulatory, or analgesic. It can cool the blood and eliminate macules, purge fire and calm endogenous wind. Indigo Naturalis has a salty and cold nature. It belongs to the liver meridian. Salt enters the blood, cold clears and relieves, and also has astringent properties. Entering the liver and lung meridians, its medicinal power is relatively strong. Taken orally, it is good at clearing heat and detoxifying, cooling the blood and eliminating macules, purging fire and calming endogenous wind; applied externally, it can clear and relieve, disperse swelling, and astringe sores. It is not only the key herb for treating epidemic febrile disease with macules, hematemesis and epistaxis due to blood heat, infantile convulsions due to liver heat, and cough due to liver fire disturbing the lung, but also commonly used for mumps, sore throat, and sores and boils. It contains indole alkaloids such as indigo and indirubin, organic acids such as tryptanthrin, quinazolinedione, and salicylic acid, glycosides such as isatan B, and inorganic elements such as iron, manganese, and zinc. Indigo Naturalis has the effects of clearing heat and detoxifying, cooling the blood and eliminating macules, purging fire and calming endogenous wind. It is used for epidemic febrile disease with macules, hematemesis due to blood heat, chest pain with hemoptysis, mouth sores, mumps, sore throat, and infantile convulsions.

[0032] (15)Pulsatilla chinensis (Bunge) Regel: It is a perennial herb of the genus Pulsatilla in the family Ranunculaceae, with a rhizome, ovate leaves, and blue-violet sepals. Aliases include Nahecao, Fenrucao, Baitoucao, Laogucao, etc. Pulsatilla chinensis (Bunge) Regel is bitter, cold in nature, and belongs to the stomach and large intestine meridians, and has the effect of cooling the blood and stopping dysentery, and is used to treat damp-heat dysentery and toxic dysentery with bloody stools; for treating toxic dysentery, it is often used together with Coptis chinensis Franch. and Cortex Fraxini, which can clear heat and dry dampness and stop dysentery. Pulsatilla chinensis (Bunge) Regel can also clear heat and detoxify, and is used to treat heat-toxic syndromes such as sores and boils, swelling and pain of hemorrhoids, etc. Taking it orally or applying it topically can achieve effects, and it is often used together with Taraxacum mongolicum Hand.-Mazz. and Forsythia suspensa (Thunb.) Vahl. Pulsatilla chinensis (Bunge) Regel has the effect of clearing the liver and improving eyesight, and is used to treat red and swollen eyes, bitter taste in the mouth, restlessness, and constipation caused by the hyperactivity of liver-fire attacking upward along the meridians, resulting in the blockage of meridians, blood stasis, qi stagnation.

[0033] (16)Coptis chinensis: The Chinese medicinal material Coptis chinensis is a heat-clearing medicine. It is the dried rhizome of Coptis chinensis Franch., Coptis deltoidea C. Y. Cheng & Hsiao or Coptis teeta Wall. of the Ranunculaceae family. Coptis chinensis is bitter in taste and cold in nature. It belongs to the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. Coptis chinensis is extremely bitter and cold, clearing and drying, purging and descending pure yin. It mainly enters the heart meridian and the stomach and spleen meridians, and also enters the liver, gallbladder, and large intestine meridians. It can both clear heat and purge fire, and dry dampness and remove dampness-toxicity to relieve damp-heat toxicity. It is a key medicine for treating damp-heat fire-toxicity and is widely used in the syndromes of damp-heat fire-toxicity. Compared with Scutellaria baicalensis Georgi, its ability to clear heat and dry dampness is stronger, and its action is biased towards the heart and the middle-jiao spleen and stomach. It is best at clearing the fire of the heart and stomach and removing the dampness of the middle-jiao. This product contains isoquinoline alkaloids such as berberine, coptisine, jatrorrhizine, palmatine, columbamine, africanine, magnoflorine, epiberberine, etc. It also contains components such as obacunone, obaculactone, ferulic acid, chlorogenic acid, etc., and has the effects of clearing heat and drying dampness, purging fire and detoxifying.

[0034] (17)Pomegranate Peel: It is the dried pericarp of Punica granatum L. of the Punicaceae family. As a Chinese medicinal material, pomegranate peel belongs to the large intestine meridian, is warm in nature, sour and astringent in taste, and has the effects of astringing the intestine to stop diarrhea, stopping bleeding, and expelling worms. It is commonly used for chronic diarrhea, chronic dysentery, hematochezia, rectal prolapse, metrorrhagia and metrostaxis, leukorrhea, and abdominal pain due to worm accumulation.

[0035] (18)Fructus Aurantii Immaturus: The Chinese medicinal material Fructus Aurantii Immaturus is a qi-regulating medicine. It is the dried immature fruit of Citrus aurantium L. and its cultivated varieties of the Rutaceae family. Pregnant women should use it with caution. Fructus Aurantii Immaturus is bitter and purging, pungent and dispersing, slightly cold and not warm. It enters the spleen, stomach meridians and the large intestine meridian, and is good at regulating the ascending and descending of the qi of the gastrointestinal tract to regulate qi and relieve fullness, and remove distension. The nature, flavor, and meridian tropism of the Chinese medicinal material Fructus Aurantii Immaturus are the same as those of Fructus Aurantii, but its effect is relatively mild. Its function is to regulate qi and relieve fullness, promote qi movement and relieve distension.

[0036] Advantages of the present invention:

[0037] 1. Improve the clinical relevant inflammatory indexes of UC patients and to a certain extent improve the quality of life of patients.

[0038] 2. Have a quick effect. After taking the medicine, the symptom of hematochezia can be reduced.

[0039] 3. The daily frequency of defecation returns to normal, the viscosity is normal, the cure is complete, and there is no recurrence.

[0040] 4. Have small side effects. After cure, no other sequelae have been found for the time being. Specific Embodiments

[0041] To further elaborate on an Ankang medicated soup for treating ulcerative colitis of the present invention and the technical means adopted to achieve the predetermined invention purpose, the following takes a preferred embodiment to describe in detail the specific embodiments and their effects according to the application of the present invention. Example 1

[0042] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 part of ginseng, 10 parts of psoralea fruit, 3 parts of evodia fruit, 1 part of nutmeg, 5 parts of gardenia fruit, 5 parts of lophatherum herb, 10 parts of talc, 10 parts of schisandra fruit, 10 parts of patrinia herb, 3 parts of chicken gizzard-membrane, 5 parts of skullcap root, 5 parts of capillary artemisia, 1 part of earthworm, and 1 part of indigo naturalis. Example 2

[0043] In this embodiment, the composition of the medicament is as follows: by weight parts, the traditional Chinese medicine comprises the following raw materials: 3 parts of ginseng, 15 parts of psoralea fruit, 5 parts of evodia fruit, 3 parts of nutmeg, 10 parts of gardenia fruit, 10 parts of lophatherum herb, 15 parts of talc, 10 parts of schisandra fruit, 15 parts of patrinia herb, 5 parts of chicken gizzard-membrane, 10 parts of skullcap root, 10 parts of capillary artemisia, 3 parts of earthworm, and 3 parts of indigo naturalis. Example 3

[0044] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 5 parts of ginseng, 20 parts of psoralea fruit, 8 parts of evodia fruit, 5 parts of nutmeg, 15 parts of gardenia fruit, 15 parts of lophatherum herb, 20 parts of talc, 15 parts of schisandra fruit, 20 parts of patrinia herb, 8 parts of chicken gizzard-membrane, 15 parts of skullcap root, 15 parts of capillary artemisia, 5 parts of earthworm, and 5 parts of indigo naturalis. Example 4

[0045] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 2 parts of ginseng, 12 parts of psoralea fruit, 4 parts of evodia fruit, 2 parts of nutmeg, 7 parts of gardenia fruit, 7 parts of lophatherum herb, 12 parts of talc, 12 parts of schisandra fruit, 12 parts of patrinia herb, 4 parts of chicken gizzard-membrane, 7 parts of skullcap root, 7 parts of capillary artemisia, 2 parts of earthworm, and 2 parts of indigo naturalis. Example 5

[0046] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 3 parts of ginseng, 15 parts of psoralea fruit, 4 parts of evodia fruit, 3 parts of nutmeg, 9 parts of gardenia fruit, 9 parts of lophatherum herb, 15 parts of talc, 12 parts of schisandra fruit, 12 parts of patrinia herb, 5 parts of chicken gizzard-membrane, 9 parts of skullcap root, 9 parts of capillary artemisia, 4 parts of earthworm, and 4 parts of indigo naturalis. Example 6

[0047] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 5 parts of ginseng, 10 parts of psoralea fruit, 8 parts of evodia fruit, 5 parts of nutmeg, 15 parts of gardenia fruit, 15 parts of lophatherum herb, 10 parts of talc, 10 parts of schisandra fruit, 10 parts of patrinia herb, 8 parts of chicken gizzard-membrane, 15 parts of skullcap root, 15 parts of capillary artemisia, 5 parts of earthworm, and 5 parts of indigo naturalis. Example 7

[0048] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 parts of evodia fruit, 5 parts of nutmeg, 5 parts of gardenia fruit, 5 parts of lophatherum herb, 20 parts of talc, 15 parts of schisandra chinensis, 20 parts of patrinia scabiosaefolia, 8 parts of chicken's gizzard-membrane, 15 parts of scutellaria baicalensis, 15 parts of virgate wormwood, 5 parts of earthworm, 5 parts of indigo naturalis. Example 8

[0049] In this embodiment, by weight parts, the traditional Chinese medicine comprises the following raw materials: 5 parts of ginseng, 15 parts of psoralea fruit, 5 parts of evodia fruit, 5 parts of nutmeg, 10 parts of gardenia fruit, 10 parts of lophatherum herb, 15 parts of talc, 10 parts of schisandra chinensis, 15 parts of patrinia scabiosaefolia, 5 parts of chicken's gizzard-membrane, 8 parts of scutellaria baicalensis, 8 parts of virgate wormwood, 3 parts of earthworm, 3 parts of indigo naturalis. Example 9

[0050] For patients with severe mucus, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra chinensis, 10 - 20 parts of patrinia scabiosaefolia, 3 - 8 parts of chicken's gizzard-membrane, 5 - 15 parts of scutellaria baicalensis, 5 - 15 parts of virgate wormwood, 1 - 5 parts of earthworm, 1 - 5 parts of indigo naturalis, 3 - 8 parts of pulsatilla chinensis. Example 10

[0051] For patients with severe abdominal pain, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra chinensis, 10 - 20 parts of patrinia scabiosaefolia, 3 - 8 parts of chicken's gizzard-membrane, 5 - 15 parts of scutellaria baicalensis, 5 - 15 parts of virgate wormwood, 1 - 5 parts of earthworm, 5 - 10 parts of indigo naturalis, 3 - 8 parts of coptis chinensis. Example 11

[0052] For patients with severe diarrhea, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1 - 5 parts of ginseng, 10 - 20 parts of psoralea fruit, 3 - 8 parts of evodia fruit, 1 - 5 parts of nutmeg, 5 - 15 parts of gardenia fruit, 5 - 15 parts of lophatherum herb, 10 - 20 parts of talc, 10 - 15 parts of schisandra chinensis, 5 - 10 parts of patrinia scabiosaefolia, 3 - 8 parts of chicken's gizzard-membrane, 5 - 15 parts of scutellaria baicalensis, 5 - 15 parts of virgate wormwood, 1 - 5 parts of earthworm, 1 - 5 parts of indigo naturalis, 8 - 15 parts of granatum peel. Example 12

[0053] For patients with severe abdominal distension, by weight parts, the traditional Chinese medicine comprises the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia rutaecarpa, 1-5 parts of nutmeg, 5-15 parts of gardenia, 5-15 parts of lophatherum gracile, 10-20 parts of talc, 10-15 parts of schizandra chinensis, 10-20 parts of patrinia scabiosaefolia, 3-8 parts of endothelium corneum gigeriae galli, 5-15 parts of scutellaria baicalensis, 5-15 parts of artemisia capillaris, 1-5 parts of pheretima, 1-5 parts of indigo naturalis, 3-8 parts of fructus aurantii (to be used with caution by pregnant women).

[0054] In the above-mentioned embodiment, when in use, divide one portion of the medicine into three equal parts, put one part into a decocting container, add clear water to submerge all the medicines, use high heat and then turn to low heat, decoct for 15-20 minutes, ladle out the decocted medicinal soup and let it cool, repeat twice, and take the medicinal soup obtained from the three decoctions orally in three divided doses within one day.

[0055] During the period of taking the medicine, spicy and stimulating foods should be fasted; take 7 doses as one course of treatment. After one course of treatment, observe its curative effect and adverse reactions, and conduct auxiliary colonoscopy examination for individual patients.

[0056] Health status recovery indicators: daily defecation frequency, bloody stool, colonoscopy findings and doctor's evaluation.

[0057] Clinical example 1:

[0058] Patient Wang, male, a company employee, 43 years old, was admitted to the hospital with the main complaint of "recurrent mucopurulent bloody stools for 15 years, aggravated for 1 week". When admitted to the hospital, the symptoms were as follows: having bowel movements 4-5 times a day, the stool was loose in texture, mixed with a large amount of mucus and purulent blood, the color of the blood was bright red, there was dull pain in the lower abdomen, which was aggravated before defecation and relieved after defecation, accompanied by tenesmus, a feeling of incomplete defecation, soreness and weakness of the waist and knees, and cold limbs, without other discomfort symptoms, normal urination, good appetite, and sound sleep at night. There was no fever, dizziness, headache, chest tightness, shortness of breath, nausea, vomiting, and no obvious change in body weight recently. The tongue was light red, the coating was thin and white, and the pulse was weak. Colonoscopy showed segmental erosion and ulcers in the mucous membranes of the ascending colon, transverse colon, descending colon, sigmoid colon and rectum. After the patient took 5 doses of the above-mentioned decoction, the frequency of bowel movements decreased to 2 times a day, the mucus and purulent blood in the stool were significantly reduced compared with before, and the tenesmus basically disappeared. The symptoms such as cold limbs of the patient were improved compared with before.

[0059] Clinical example 2

[0060] Patient Zhao Qiang, male, a civil servant, 56 years old, was admitted to the hospital with the chief complaint of "recurrent mucopurulent bloody stools for more than 10 years, aggravated for 1 day". When admitted to the hospital, the symptoms were as follows: defecation 5-6 times a day, the stool was unformed, a large amount of mucus and purulent blood were mixed in the stool, the blood color was bright red, there was dull pain in the left lower abdomen, which was aggravated before defecation and relieved after defecation, accompanied by a sense of anal sagging and incomplete defecation, without other discomfort symptoms, normal urination, normal diet and sleep. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and no obvious change in weight recently. Past history: 11-year history of type 2 diabetes; half a year of hyperlipidemia, currently taking rosuvastatin calcium tablets 10mg / day; 3 years after minimally invasive surgery for pulmonary nodules, denying other surgical and trauma histories; having an allergic history to cephalosporin batch numbers. The tongue was pale red, the coating was white and greasy, and the pulse was weak. No obvious abnormalities were found in the specialist examination. The electronic colonoscopy on admission showed scattered erosions in the mucosa of the descending colon and sigmoid colon, and the rectal mucosa was congested, edematous, and the vascular texture was rough and disordered. Imaging opinion: ulcerative colitis (recovery period). After the patient took the above decoction for 5 doses, the number of stools decreased to 3 times a day, the purulent blood in the stool disappeared, and a small amount of mucus was occasionally seen. The abdominal pain was significantly relieved compared with before, and the sense of anal sagging and incomplete defecation basically disappeared.

[0061] Clinical Example 3

[0062] Patient Chen Hong, male, an unemployed person, 54 years old, was admitted to the hospital with the chief complaint of "intermittent mucopurulent bloody stools for 2 years, aggravated for 1 week". When admitted to the hospital, the symptoms were as follows: defecation 4-5 times a day, the stool was unformed, a large amount of mucus and a small amount of purulent blood were mixed in the stool, the blood color was dark red, there was dull pain around the umbilicus, which was aggravated before defecation and relieved after defecation, with an obvious sense of incomplete defecation and anal sagging. The tongue was red, the coating was yellow and greasy, and the pulse was stringy and slippery. Past history: 8 years ago, due to cerebral hemorrhage, rescue and minimally invasive treatment were performed, and postoperative wound scars could be seen on the head. Currently, the patient has poor language ability and no obvious limb movement disorders. Hypertension history for more than 10 years. The specialist examination showed mild tenderness around the umbilicus. The colonoscopy on admission showed: multiple polyps in the colon, ulcerative colitis (proctitis type), and polypectomy had been performed. After the patient took the above decoction for 7 doses, the number of stools decreased to 2 times a day, the stool was loose, and the mucus and purulent blood in the stool basically disappeared. The abdominal pain was significantly relieved compared with before, and the sense of anal sagging and incomplete defecation basically disappeared. After taking the decoction for another 5 doses, the patient's stool was basically formed. The tongue was red, the coating turned to thin yellow, and the pulse was slippery.

[0063] Clinical Case 4

[0064] Patient Zhang Muli, male, a property employee, 58 years old, was admitted to the hospital with the chief complaint of "recurrent mucopurulent bloody stools for four and a half years, aggravated for 2 days". When admitted to the hospital, the symptoms were as follows: having bowel movements more than 10 times a day, the stool was unformed, mixed with a large amount of mucus and purulent blood, the blood color was bright red, sometimes only mucus and purulent blood were discharged, there was distending pain around the umbilicus, which was aggravated before defecation and relieved after defecation, accompanied by tenesmus and a feeling of incomplete defecation, and a burning discomfort in the anus after defecation. There was dull pain in the epigastrium after meals, the urine was slightly frequent, and the diet and sleep were normal. Past history: had a history of chronic atrophic gastritis for 3 months; occasionally had slightly elevated blood sugar; had received blood transfusion treatment due to anemia after bloody stools. The tongue was red, the tongue coating was yellow and greasy, and the pulse was slippery. Special examination showed mild tenderness around the umbilicus. Electronic colonoscopy showed that the mucosa of the ascending colon was red and swollen. The mucosa of the transverse colon, descending colon, sigmoid colon and rectum was eroded, ulcerated with hyperplastic polyps formed. One piece of tissue was taken about 30 cm from the anus and sent for pathology. The examination showed: ulcerative colitis with hyperplastic polyps formed. Pathology showed: (colon) chronic inflammation. After the patient took the above decoction for 7 doses, the bowel movements decreased to 4 times a day, the mucus and purulent blood in the stool were significantly reduced, the abdominal distension basically disappeared, the urine was normal, the tongue was light red, the tongue coating turned to thin yellow, and the pulse was slippery.

[0065] Clinical Case 5

[0066] Patient Shi Zhen, female, a retiree, 62 years old, was admitted to the hospital with the chief complaint of "recurrent mucopurulent bloody stools for more than 10 years, aggravated for 2 days." When admitted to the hospital, the symptoms were as follows: having bowel movements 4 - 5 times a day, the stool was unformed, mixed with a large amount of mucus and purulent blood, there was dull pain in the left lower abdomen, which was aggravated before defecation and relieved after defecation, accompanied by a feeling of anal prolapse and incomplete defecation, occasionally had dry mouth, no other discomfort symptoms, the urine was normal, and the diet and sleep at night were normal. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and there has been no obvious change in body weight recently. Past history of hypertension for 4 years. The tongue was light red, the tongue coating was white and greasy, and the pulse was weak. Special examination showed mild tenderness in the left lower abdomen. Colonoscopy showed (2021 - 04 - 09): ulcerative colitis, multiple polyps in the colon (polyps have been removed). After the patient took the above decoction for 7 doses, the bowel movements decreased to 3 times a day, the stool was soft and formed, the mucus and purulent blood in the stool were significantly reduced, the abdominal distension basically disappeared, the urine was normal, the tongue was light red, the tongue coating turned to thin white, and the pulse was weak.

[0067] Clinical Case 6

[0068] Patient Yu Moubo, female, 53 years old, retired, was admitted to the hospital with the chief complaint of "recurrent mucopurulent bloody stools for 2 months and aggravated for 5 days". When admitted to the hospital, the symptoms were as follows: having bowel movements 3 - 4 times a day, the stool was unformed, mixed with a moderate amount of mucus and purulent blood, the blood color was bright red, there was a feeling of incomplete defecation and a sense of anal prolapse after defecation, there was dull pain and discomfort in the lower abdomen, which was aggravated before defecation and relieved after defecation, without other discomfort symptoms, normal urination, normal diet, but poor sleep. Since the onset of the disease, there has been no fever and no obvious change in body weight. Past history: having a history of hypertension for 3 years, the highest blood pressure reached 160 / 100 mmHg, and currently taking telmisartan to control blood pressure. Denied a history of diabetes, heart disease and other chronic diseases. Had a mixed hemorrhoid operation in this hospital 5 years ago, denied other surgical trauma history. Denied a history of hepatitis, tuberculosis and other infectious diseases, vaccinated as scheduled, denied a family history of genetic diseases, denied a history of drug and food allergies. The tongue was light red, the coating was white and greasy, and the pulse was weak. There was no obvious abnormality in the specialist examination. Colonoscopy showed: scattered punctate white ulcers in the cecal mucosa; hyperemia and edema in the ascending colon mucosa; scattered punctate white ulcers in the transverse colon and descending colon mucosa; erosion and ulcers in the sigmoid colon and rectal mucosa. After the patient took the above decoction for 5 doses, the bowel movements decreased to 2 times a day, the stool was soft and formed, the mucus and purulent blood in the stool were significantly reduced, the abdominal pain basically disappeared, the urination was normal, the tongue was light red, the coating turned to thin white, and the pulse was weak.

[0069] Clinical Case 7

[0070] Patient Tong Mouhe, male, 41 years old, self-employed, was admitted to the hospital with the chief complaint of "recurrent mucopurulent bloody stools for more than half a year and aggravated for 1 week". More than half a year ago, the patient had mucopurulent bloody stools after getting cold, the blood color was bright red. Colonoscopy was performed at Shengjing Hospital Affiliated to China Medical University: ulcerative proctosigmoiditis, colonic laterally spreading tumor (electrosection has been performed, postoperative pathology: tubular adenoma). Then, the patient was hospitalized in Shengjing Hospital of China Medical University for systematic treatment. During the hospitalization, mesalazine enteric-coated tablets and enema were used for treatment, and the patient was discharged after the condition improved. After that, the patient has been taking mesalazine preparations orally and by enema for a long time to control the condition. 1 month ago, when the patient monitored liver function, it was found that the transaminase increased, and then bicyclol tablets were taken orally for liver protection treatment. After taking this medicine, the patient developed a rash on the back of the neck, the rash was higher than the skin, and there was a feeling of itching, and the patient did not receive systematic diagnosis and treatment. 1 week ago, the patient's condition recurred and aggravated again without obvious incentive. In order to seek systematic traditional Chinese medicine treatment, the patient came to our hospital for treatment today, and then was admitted to our ward with the diagnosis of "ulcerative proctosigmoiditis, moderate". Symptoms on admission: having bowel movements 3 - 5 times a day, the stool was unformed, mixed with a moderate amount of mucus and purulent blood, the blood color was bright red, accompanied by dull pain in the lower abdomen, aggravated before defecation and relieved after defecation, accompanied by a feeling of incomplete defecation, slightly bloated, normal urination, normal diet and sleep. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and no obvious weight loss recently. After the patient took the above decoction for 5 doses, the bowel movements decreased to 2 times a day, the stool was soft and formed, the mucus and purulent blood in the stool were significantly reduced, the abdominal distension basically disappeared, the urination was normal, the tongue was light red with white coating, and the pulse was weak.

[0071] Clinical Case 8

[0072] The patient, Zhang Moumei, female, 47 years old, an employee, was admitted to the hospital with the main complaint of "recurrent mucus, pus and blood stools for 5 years, aggravated for 1 month". Symptoms at admission: 2-3 bowel movements a day, unformed stools, moderate amounts of mucus and pus and blood mixed in the stools, bright red blood, occasional dull pain in the lower abdomen, aggravated before defecation, relieved after defecation, feeling of incomplete defecation, self-reported prolapse of hemorrhoids in the anus during defecation, which can be returned by itself, dull pain and discomfort in the epigastric region, occasional acid reflux and heartburn, no other discomfort symptoms, normal urination, diet and sleep at night. There was no fever, no dizziness or headache, no chest tightness and shortness of breath, no nausea and vomiting, and no significant change in weight recently. Past history: 3 years of mixed hemorrhoids, surgical treatment at a local private clinic in 2023, and recurrence after surgery. The tongue is pale red, the tongue coating is thin and white, and the pulse is weak. There were no obvious abnormalities in the specialist examination. Auxiliary examination: Colonoscopy in our hospital showed: ulcerative pancolitis, cecal mucosal erosion and ulcers; partial ascending colon mucosal erosion and ulcers; rectal mucosal erosion. After taking 5 doses of the above decoction, the patient had bowel movements twice a day, the stools were soft and formed, there was no obvious mucus, pus or blood in the stools, the dull pain in the abdomen and epigastric area basically disappeared, urination was normal, the tongue was pale with white fur, and the pulse was weak.

[0073] Clinical Case 9

[0074] The patient, Qu Moufu, male, 60 years old, retired, was admitted to the hospital with the main complaint of "recurrent mucus, pus and blood stool for more than 1 year, aggravated for 1 week". Admission symptoms: 5-6 bowel movements per day, unformed stool, a large amount of mucus and pus and blood mixed in the stool, bright red blood, dull pain below the navel, aggravated before defecation and relieved after defecation, accompanied by a feeling of anal prolapse, a feeling of incomplete defecation, a feeling of tenesmus, conscious fear of cold, occasionally accompanied by acid reflux and heartburn, no other discomfort symptoms, normal urination, good diet, poor sleep at night. No fever, no dizziness and headache, no chest tightness and shortness of breath, no nausea and vomiting, and a weight loss of 10 pounds in the past year. Past history is healthy. Specialist examinations indicate mild tenderness around the navel. Auxiliary examinations: Colonoscopy (2023.11.16): ulcerative proctosigmoiditis. Gastroscopy (2023.11.16): chronic atrophic gastritis C1. After the patient took the above decoction orally for 5 doses, he had bowel movements twice a day, and his stools were soft and formed, without obvious mucus, pus and blood in the stools. The dull pain in the abdomen and epigastric region basically disappeared, and his urination was normal. His tongue was pale with white fur, and his pulse was weak. After the patient took the above decoction orally for 5 doses, he had bowel movements twice a day, and his stools were soft and formed, without obvious mucus, pus and blood in the stools. The pain in the abdomen basically disappeared, and the symptoms of yang deficiency such as fear of cold were significantly relieved compared with before. He gained 0.5kg, had a pale tongue with white fur, and his pulse was weak.

[0075] Clinical Case 10

[0076] Patient Liu Wei, male, 67 years old, retired. He was admitted to the hospital with the main complaint of "recurrent mucopurulent bloody stools for more than 1 month, aggravated for 3 days". More than 1 month ago, there was no obvious incentive for the appearance of mucopurulent bloody stools in the stool. Colonoscopy in our hospital showed: ulcerative colitis (extensive colon). Then he was admitted to the hospital for systematic treatment and was discharged after the condition improved. 3 days ago, due to emotional discomfort, the above symptoms reappeared and were aggravated. In order to seek systematic treatment, he came to our hospital today and was admitted to our department for inpatient systematic treatment through the outpatient department. Symptoms on admission: The stool is about 3-4 times a day, the stool quality is thin, mixed with a large amount of mucopurulent blood, the pus and blood are bright red, mixed in the feces, and it is aggravated after each emotional excitement. There is dull pain in the abdomen, mainly around the umbilicus. Diarrhea occurs immediately after abdominal pain, and the pain is relieved after diarrhea. There is a feeling of incomplete defecation, a sense of anal prolapse, and tenesmus. Since the onset of this disease, the patient's mental state has been okay, with anxiety, normal appetite, normal sleep at night, no fever or other discomforts, no nausea or vomiting, and the weight has decreased by about 10 catties in the recent more than 1 month. The tongue is light red, the coating is thin and white, and the pulse is stringy. After the patient took the above decoction for 5 doses, the stool was 2 times a day, the stool quality was soft and formed, there was no obvious mucopurulent blood in the stool, the dull pain in the abdomen basically disappeared, the urine was normal, the weight increased by 0.5 kg, the tongue was light, the coating was white, and the pulse was weak.

[0077] Clinical Case 11

[0078] Patient Wang Jiejie, female, 54 years old, retired. The patient was admitted to the hospital with the main complaint of "recurrent mucopurulent bloody stools for 3 years, aggravated for 3 days". The patient reported that there was no obvious incentive for the appearance of mucopurulent bloody stools in the stool 3 years ago, and the blood color was bright red or dark red. Colonoscopy was performed at Zhongtai Anorectal Hospital: ulcerative proctitis. Then, traditional Chinese medicine enema and other treatments were performed in that hospital, and the treatment was stopped after the condition improved. Since then, the mucopurulent bloody stools have occurred intermittently, and the specific diagnosis and treatment process is unknown. Half a year ago, the patient had mucopurulent bloody stools again. Colonoscopy was performed in our hospital: ulcerative proctitis, colorectal polyps (electrosection has been performed). Then, the condition improved after treatment in our hospital, but the treatment was not continued. Symptoms on admission: The stool is about 4-5 times a day, the stool is unformed, mixed with a large amount of mucus and pus and blood in the stool, the blood color is dark red, accompanied by dull pain and discomfort in the lower abdomen, a feeling of incomplete defecation and a sense of anal prolapse, and the patient reported more flatulence, accompanied by soreness and weakness in the waist and knees, and cold limbs. The appetite is normal, and the sleep is poor. Since the onset of the disease, there has been no fever, no nausea or vomiting, no obvious fatigue, and the weight has not changed significantly. The patient has had hypertension for more than 10 years. After the patient took the above decoction for 5 doses, the stool was 2 times a day, the stool quality was soft and formed, there was no obvious mucopurulent blood in the stool, the abdominal pain basically disappeared, and the yang deficiency symptoms such as fear of cold were significantly relieved compared with before. The weight increased by 0.5 kg, the tongue was light, the coating was white, and the pulse was weak.

[0079] Clinical Case 12

[0080] Patient Guo, male, 41 years old, employee. The patient was admitted to the hospital with the main complaint of "recurrent episodes of mucus, pus and blood in stool for 6 years, aggravated for 2 months". The patient reported that he had abdominal pain, diarrhea, mucus and blood in stool without obvious causes 6 years ago. On October 9, 2018, a colonoscopy in our hospital revealed ulcerative colitis and multiple polyps in the colon. The symptoms were mild and severe and recurrent. He usually took mesalazine suppositories to control the condition. He was hospitalized in our hospital and was discharged after his condition improved. 2 months ago, the patient's condition worsened without obvious causes, and the number of bowel movements increased significantly, accompanied by lower abdominal distension and stomach acid reflux. In order to seek systematic treatment, he sought treatment in our outpatient clinic and was admitted to our ward with the diagnosis of "ulcerative pancolitis, moderate" by the outpatient clinic. The tongue is pale red, the tongue coating is white and greasy, and the pulse is weak. Symptoms at admission: 4-6 bowel movements per day, unformed stools, occasional undigested food in the stools, moderate amounts of mucus and pus and blood mixed in the stools, bright red blood, lower abdominal distension and pain, tenesmus, feeling of incomplete bowel movements, discomfort and discomfort in the anus after bowel movements, acid reflux and pain in the stomach, normal urination, and normal diet and sleep. The patient was tired and listless when the disease came, without fever, chest tightness and shortness of breath, nausea and vomiting, and no significant changes in weight recently. Past history: In 2012, he underwent surgery for hemorrhoids at Shenyang Anorectal Hospital; on October 9, 2018, he underwent electroresection of intestinal polyps at our hospital. The tongue was pale red with tooth marks, thin white fur, and weak pulse. No obvious abnormalities were found in the specialist examination. Colonoscopy in our hospital revealed ulcerative colitis and multiple polyps in the colon. After the patient took 5 doses of the above decoction orally, he had bowel movements twice a day, the stools were soft and formed, there was no obvious mucus, pus or blood in the stools, the bloating and pain in the abdomen and epigastric area basically disappeared, the tongue was pale with white coating, and the pulse was weak.

[0081] Clinical Case 13

[0082] The patient, Mr. Pan, is a 52-year-old male employee. The patient was admitted to the hospital with the main complaint of "recurrent bloody stools for 7 years, aggravated for 1 month". The patient reported that he had mucus, pus and blood in his stools without obvious causes 7 years ago, accompanied by abdominal pain and diarrhea. He had a colonoscopy in our hospital and was diagnosed with ulcerative proctitis. He was hospitalized in our hospital for treatment and was discharged after recovery. Over the past 7 years, the disease has recurred, sometimes mild and sometimes severe. He has been hospitalized in our hospital many times and was discharged after his condition improved. One month ago, the patient's condition relapsed and worsened without obvious causes. In order to seek systematic traditional Chinese medicine treatment, the patient came to our hospital for treatment today. Later, he was admitted to our treatment area with the diagnosis of "ulcerative proctitis, moderate" by the outpatient department. Symptoms at admission: 1-2 bowel movements per day, loose stools, slightly labored stools, moderate amounts of mucus and pus and blood mixed in the stools, bright red pus and blood, dull pain in the lower abdomen, aggravated before defecation and relieved after defecation, feeling of incomplete defecation, no other discomfort symptoms, normal urination, diet and sleep. No fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, no significant weight changes recently. Previous history of hypertension; 2-year history of elevated blood sugar. Specialist examination showed mild tenderness around the umbilicus. After taking 5 doses of the above decoction, the patient had a bowel movement once a day, soft and formed stools, no obvious mucus, pus and blood in the stools, almost disappeared dull abdominal pain, pale tongue with white fur, and weak pulse.

[0083] Clinical Case 14

[0084] Patient Wang Mouxin, male, 33 years old, an art practitioner. More than 1 year ago, there was mucus, pus and blood in the stool without obvious incentive. Colonoscopy at the Fourth Affiliated Hospital of Harbin Medical University showed: ulcerative colitis (extensive colon type), colonic polyps. Later, following the doctor's advice, he took "Asacol" 4.0 g / day and probiotic drugs orally. The patient's condition improved, and the mucus, pus and blood in the stool disappeared. Later, due to busy work, mucus, bloody stools appeared again, and the amount of blood increased compared with before. In order to seek systematic treatment, the patient came to our hospital and was admitted to our department for inpatient systematic treatment through the outpatient department. Current symptoms: The stool is about 4 - 5 times a day, the stool quality is loose, mixed with a lot of mucus, pus and blood, the pus and blood are bright red, mixed in the feces, and it gets worse every time after emotional excitement. There is dull pain in the abdomen, mainly around the umbilicus. Diarrhea occurs immediately after the abdominal pain, and the pain is relieved after diarrhea, accompanied by borborygmus and passing of flatus. Since the onset of this disease, the patient's mental state has been okay, but he is anxious, has a good appetite, has poor sleep at night, has no fever or other discomforts, no nausea or vomiting, normal urination, and no obvious change in weight recently. The tongue is light red, with tooth marks, the tongue coating is thin and white, and the pulse is weak. After the patient took the above-mentioned decoction for 7 doses, the stool was 2 times a day, the stool quality was soft and formed, there was no obvious mucus, pus and blood in the stool, the abdominal pain basically disappeared, the tongue was light, the tooth marks became lighter, the tongue coating was white, and the pulse was weak.

[0085] Clinical Case 15

[0086] Patient Pei Mou, male, 30 years old, a civil servant. More than 10 years ago, there was mucus, bloody stools without obvious incentive. Colonoscopy was performed in our hospital and other hospitals for many times, showing: ulcerative colitis. During the illness, the patient intermittently used mesalazine preparations and traditional Chinese medicine for symptomatic treatment, and the condition was stable most of the time. 2 years ago, the condition aggravated without obvious incentive. He took hormones orally for half a month for symptomatic treatment. The patient's condition recovered well, and the dosage was gradually reduced until the drug was stopped and the condition was stable. 1 week ago, the condition recurred and aggravated again without obvious incentive. In order to seek systematic integrated traditional Chinese and Western medicine diagnosis and treatment, the patient came to our hospital today and was admitted to our ward with the diagnosis of "ulcerative colitis" through the outpatient department. Current symptoms: The stool is 4 - 5 times a day, the stool is loose, mixed with undigested food, mixed with a lot of mucus, pus and blood in the stool, the blood color is dark red, there is intermittent dull pain around the umbilicus, which can be relieved by itself, there is an obvious feeling of incomplete defecation, and there is pain and swelling in the anus after defecation. Since the onset of the disease, the patient has been tired, has a good appetite, has poor sleep at night, normal urination, no fever, no joint pain and other related symptoms, no nausea or vomiting, and no obvious change in weight recently. The tongue is light red, with tooth marks, the tongue coating is thin and white, and the pulse is weak. After the patient took the above-mentioned decoction for 7 doses, the stool was 2 times a day, the stool quality was soft and formed, there was no obvious mucus, pus and blood in the stool, the abdominal pain basically disappeared, the tongue was light, the tooth marks became lighter, the tongue coating was white, and the pulse was weak.

[0087] Clinical Case 16

[0088] Patient Wu Mouyi, male, 71 years old, retired. The patient reported that 2 years ago, he had abdominal pain, diarrhea, and mucus bloody stools without obvious inducement. Colonoscopy examination in an external hospital showed ulcerative colitis. In the past 2 years, the condition has relapsed repeatedly, sometimes mild and sometimes severe. He has been hospitalized in our hospital many times and was discharged after the condition improved. 3 days ago, the patient's condition relapsed and worsened again without obvious inducement. Today, in order to seek systematic treatment, he was admitted to our hospital. The outpatient diagnosis was "ulcerative proctosigmoiditis, moderate". When admitted to the hospital, the symptoms were as follows: defecation 3 - 5 times a day, the stool was unformed, mixed with a large amount of mucus and purulent blood, the blood color was bright red, dull pain in the left lower abdomen, aggravated before defecation and relieved after defecation, accompanied by a sense of anal prolapse and incomplete defecation. There were no other uncomfortable symptoms, urine was normal, diet and sleep at night were both normal. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and there has been no obvious change in weight recently. The patient has always been in good health. After the patient took the above decoction for 7 doses, the defecation was 2 times a day, the stool was soft and formed, only a small amount of mucus was mixed in the stool, and there was no purulent blood. The abdominal pain basically disappeared.

[0089] Clinical Case 17

[0090] Patient Zhao Mouyang, male, 32 years old, an employee of a state-owned enterprise. The patient reported that more than 9 years ago, he had an increase in the number of stools, unformed stools, and a large amount of mucus and purulent blood mixed in the stools without obvious inducement. He came to our hospital for treatment. Colonoscopy examination showed ulcerative colitis, and he was hospitalized in our hospital many times and was discharged after the condition improved. In the past 9 years, the condition has relapsed repeatedly, sometimes mild and sometimes severe. 2 days ago, the patient's condition relapsed and worsened again without obvious inducement. Today, in order to seek systematic diagnosis and treatment, the patient came to our hospital. The outpatient diagnosis was "ulcerative proctosigmoiditis, moderate" and was admitted to our department. The symptoms when admitted to the hospital were as follows: defecation 4 - 5 times a day, the stool was unformed, mixed with a large amount of mucus and purulent blood, the blood color was bright red, dull pain in the left lower abdomen, aggravated before defecation and relieved after defecation, accompanied by tenesmus and incomplete defecation, occasionally acid reflux and dull pain in the epigastrium. There were no other uncomfortable symptoms, urine was normal, diet was okay, and sleep at night was poor. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and there has been no obvious change in weight recently. After the patient took the above decoction for 7 doses, the defecation was 2 times a day, the stool was soft and formed, only a small amount of mucus was mixed in the stool, and there was no purulent blood. The abdominal pain basically disappeared.

[0091] Clinical Case 18

[0092] Patient Pang, female, 61 years old, retired, was admitted to the hospital with the chief complaint of "recurrent purulent and bloody stools for 9 years, aggravated for 1 week". The patient reported that 9 years ago, mucus, purulent and bloody stools occurred without obvious cause. In the past 9 years, the above symptoms have recurred with varying degrees of severity. She has visited our hospital many times. Colonoscopy in our hospital showed: ulcerative colitis (left colon), and she was hospitalized for treatment many times. After the condition was completely relieved, she was discharged. After discharge, the condition occasionally recurred without medication. 1 week ago, due to getting cold, the symptoms recurred and worsened. In order to seek systematic treatment, she came to our hospital today and was admitted to our department with the diagnosis of "ulcerative pancolitis, moderate" through the outpatient department. Symptoms on admission: having bowel movements 5-6 times a day, the stool is thin and loose, mixed with a large amount of mucus and a small amount of purulent blood, the blood color is bright red, there is paroxysmal dull pain in the left lower abdomen, which is aggravated during defecation and relieved after defecation, accompanied by a feeling of incomplete defecation, a burning discomfort in the anus after defecation, soreness in the waist and knees, and a relatively heavy feeling of fatigue, normal appetite, poor sleep at night, normal urination, no other discomfort, and no obvious change in recent body weight. After the patient took the above decoction for 7 doses, she had bowel movements 2 times a day, the stool was soft and formed, only a small amount of mucus was mixed in the stool, no purulent blood was seen, and the abdominal pain basically disappeared.

[0093] Clinical Case 19

[0094] Patient Qian, male, 36 years old, an office worker, was admitted to the hospital with the chief complaint of "recurrent mucus, purulent and bloody stools for 4.5 years, aggravated for 1 week". The patient reported that 4.5 years ago, the frequency of bowel movements increased without obvious cause, the stool was unformed, and mucus and purulent blood were mixed in the stool. He visited our hospital, and colonoscopy showed: ulcerative colitis. Then he was hospitalized in our hospital for treatment and discharged after the condition improved. In the past 4.5 years, the condition has recurred with varying degrees of severity. 1 week ago, the patient's condition relapsed and worsened without obvious cause. Now, in order to seek systematic treatment, he came to our hospital and was admitted to our department with the diagnosis of "ulcerative colitis" through the outpatient department. Symptoms on admission: having bowel movements 4-5 times a day, the stool is unformed, mixed with a large amount of mucus and purulent blood, the color is bright red, dull pain in the lower abdomen, aggravated before defecation and relieved after defecation, accompanied by a sense of tenesmus and incomplete defecation, and occasional dull pain and discomfort in the epigastrium after meals, no other discomfort symptoms, normal urination, normal diet and sleep. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and no obvious change in recent body weight. After the patient took the above decoction for 5 doses, he had bowel movements 2 times a day, the stool was soft and formed, only a small amount of mucus was mixed in the stool, no purulent blood was seen, the abdominal pain basically disappeared, and the sense of tenesmus was significantly relieved compared with before.

[0095] Clinical Case 20

[0096] Patient Lu Mouhui, male, 41 years old, was admitted to the hospital with the main complaint of "recurrent mucopurulent bloody stools for 5 and a half years, aggravated for 1 week". Five and a half years ago, there was no obvious cause for mucus and purulent blood in the stool, and the number of bowel movements increased. In 2018, electronic colonoscopy in our hospital showed ulcerative colitis. Subsequently, mesalazine preparations and traditional Chinese medicine enemas were used intermittently for symptomatic treatment, and the condition was sometimes mild and sometimes severe. Over the past 5 and a half years, the condition has recurred repeatedly, sometimes mild and sometimes severe, and the patient has been hospitalized in our hospital many times and discharged after the condition improved. One week ago, the patient's condition recurred and worsened again without obvious cause. Now, in order to seek systematic treatment, the patient came to our hospital and was admitted to our ward with the diagnosis of "ulcerative proctosigmoiditis, moderate". The symptoms on admission were as follows: 4-5 bowel movements per day, unformed stools, mixed with a large amount of mucus and purulent blood in the stools, bright red blood color, dull pain in the left lower abdomen, aggravated before defecation and relieved after defecation, accompanied by a feeling of incomplete defecation and a sense of anal sagging, occasionally dull pain and discomfort in the epigastric region, no other discomfort symptoms, normal urination, normal diet and sleep, and the patient was anxious. Since the onset of the disease, there has been no fever, no dizziness or headache, no chest tightness or shortness of breath, no nausea or vomiting, and there has been no obvious change in body weight recently. After the patient took 5 doses of the above-mentioned decoction, the bowel movements were 2 times a day, the stools were soft and formed, the mucus and purulent blood in the stools were significantly reduced, the dull pain in the abdomen basically disappeared, the feeling of incomplete defecation basically disappeared, and the patient's mood improved.

[0097] The modified Mayo score is used to evaluate the clinical treatment efficacy of UC patients, mainly from the number of bowel movements, endoscopic findings of bloody stools, and the overall evaluation of the physician, as shown in Table 6.

[0098]

[0099] Note: ① Each subject serves as his own control to evaluate the degree of abnormality of the number of bowel movements; ② The daily bleeding score represents the most severe bleeding situation in 1 day; ③ The overall evaluation of the physician includes 3 criteria: the subject's recall of abdominal discomfort, overall well-being, and other manifestations, such as physical examination findings and the subject's performance status. The total score ≤ 2 points and no single sub-item score > 1 point indicate clinical remission, 3-5 points indicate mild activity, 6-10 points indicate moderate activity, 11-12 points indicate severe activity, and effective is defined as a decrease in score relative to the baseline value ≥ 30% and ≥ 3 points, and a decrease in the sub-item score of bloody stools ≥ 1 point or the sub-item score is 0 or 1 point.

[0100] For the evaluation of the endoscopic mucosal morphology, refer to the Baron endoscopic score, as shown in Table 7.

[0101]

[0102] The above are only the preferred specific embodiments of the invention, but the protection scope of the invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the invention should cover within the protection scope of the invention any equivalent replacement or change made according to the technical solution and concept of the invention.

Claims

1. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, By weight parts, the traditional Chinese medicine is composed of the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia fruit, 1-5 parts of nutmeg, 5-15 parts of gardenia fruit, 5-15 parts of lophatherum herb, 10-20 parts of talc, 10-15 parts of schizandra fruit, 5-20 parts of patrinia herb, 3-8 parts of chicken gizzard-membrane, 5-15 parts of scutellaria root, 5-15 parts of capillary artemisia, 1-5 parts of earthworm, 1-10 parts of indigo naturalis.

2. An ankang medicinal soup for treating ulcerative colitis, characterized in that, By weight parts, the traditional Chinese medicine is composed of the following raw materials: 2-4 parts of ginseng, 12-18 parts of psoralea fruit, 4-6 parts of evodia fruit, 2-4 parts of nutmeg, 8-12 parts of gardenia fruit, 8-12 parts of lophatherum herb, 12-18 parts of talc, 12-18 parts of schizandra fruit, 12-18 parts of patrinia herb, 4-6 parts of chicken gizzard-membrane, 8-12 parts of scutellaria root, 8-12 parts of capillary artemisia, 2-4 parts of earthworm, 2-4 parts of indigo naturalis.

3. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, By weight parts, the traditional Chinese medicine is composed of the following raw materials: 3 parts of ginseng, 15 parts of psoralea fruit, 5 parts of evodia fruit, 3 parts of nutmeg, 10 parts of gardenia fruit, 10 parts of lophatherum herb, 15 parts of talc, 10 parts of schizandra fruit, 15 parts of patrinia herb, 5 parts of chicken gizzard-membrane, 10 parts of scutellaria root, 10 parts of capillary artemisia, 3 parts of earthworm, 3 parts of indigo naturalis.

4. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, For patients with severe mucus, by weight parts, the traditional Chinese medicine is composed of the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia fruit, 1-5 parts of nutmeg, 5-15 parts of gardenia fruit, 5-15 parts of lophatherum herb, 10-20 parts of talc, 10-15 parts of schizandra fruit, 10-20 parts of patrinia herb, 3-8 parts of chicken gizzard-membrane, 5-15 parts of scutellaria root, 5-15 parts of capillary artemisia, 1-5 parts of earthworm, 1-5 parts of indigo naturalis, 3-8 parts of Chinese pulsatilla root.

5. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, For patients with severe abdominal pain, by weight parts, the traditional Chinese medicine is composed of the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia fruit, 1-5 parts of nutmeg, 5-15 parts of gardenia fruit, 5-15 parts of lophatherum herb, 10-20 parts of talc, 10-15 parts of schizandra fruit, 10-20 parts of patrinia herb, 3-8 parts of chicken gizzard-membrane, 5-15 parts of scutellaria root, 5-15 parts of capillary artemisia, 1-5 parts of earthworm, 5-10 parts of indigo naturalis, 3-8 parts of coptis root.

6. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, For patients with severe diarrhea, by weight parts, the traditional Chinese medicine is composed of the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia fruit, 1-5 parts of nutmeg, 5-15 parts of gardenia fruit, 5-15 parts of lophatherum herb, 10-20 parts of talc, 10-15 parts of schizandra fruit, 5-10 parts of patrinia herb, 3-8 parts of chicken gizzard-membrane, 5-15 parts of scutellaria root, 5-15 parts of capillary artemisia, 1-5 parts of earthworm, 1-5 parts of indigo naturalis, 8-15 parts of granatum peel.

7. An Ankang medicinal soup for treating ulcerative colitis, characterized in that, For patients with severe abdominal distension, by weight parts, the traditional Chinese medicine is composed of the following raw materials: 1-5 parts of ginseng, 10-20 parts of psoralea fruit, 3-8 parts of evodia fruit, 1-5 parts of nutmeg, 5-15 parts of gardenia fruit, 5-15 parts of lophatherum herb, 10-20 parts of talc, 10-15 parts of schizandra fruit, 10-20 parts of patrinia herb, 3-8 parts of chicken gizzard-membrane, 5-15 parts of scutellaria root, 5-15 parts of capillary artemisia, 1-5 parts of earthworm, 1-5 parts of indigo naturalis, 3-8 parts of immature bitter orange.

8. The Ankang medicated soup for treating ulcerative colitis according to claim 1, wherein, Adopt the decocting method. Divide a portion of medicinal raw materials into three equal parts. Put one part into a decocting container, add clear water to submerge all the medicines, bring to a boil over high heat and then turn to low heat for decocting for 15 - 20 minutes. Strain out the decoction and let it cool. Repeat this process two more times. Take the decoctions obtained from the three times of decocting orally in three equal portions within one day.

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