A traditional Chinese medicine composition for treating neurological symptoms of canine distemper and its preparation method

Abstract

The present invention provides a traditional Chinese medicine composition for treating neurological symptoms of canine distemper and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 5-10 parts of donkey-hide gelatin, 2-20 parts of tortoise shell glue, 2-10 parts of turtle shell glue, 2-10 parts of white atractylodes, 2-10 parts of ophiopogon, 5-15 parts of white peony root, 5-15 parts of poria, 5-15 parts of ginger, 5-15 parts of evodia, 5-15 parts of arisaema, 5-15 parts of calamus, 5-10 parts of wolfberry, 2-10 parts of dodder seed, and drynaria rhizome. The traditional Chinese medicine composition of the present invention has the functions of calming the liver and suppressing yang, calming wind, nourishing the liver and kidney, clearing away heat and calming convulsions, and treating epilepsy and convulsions. It has a good therapeutic effect on the neurological symptoms such as muscle twitching, circling, bumping, foaming at the mouth, clenched jaw, falling to the ground and convulsions caused by wind-heat internal movement caused by canine distemper, depletion of body fluids, heat toxins entering the blood, and liver-wind internal movement, which are manifested by convulsions.

Description

Technical Field

[0001] The invention belongs to the technical field of veterinary traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating canine distemper with neurological symptoms and a preparation method thereof. Background Art

[0002] Canine distemper is an acute, febrile, highly contagious disease caused by the canine distemper virus. Clinically, the disease is characterized by biphasic fever, acute rhinorrhoea, bronchitis, catarrhal pneumonia, gastroenteritis, and neurological symptoms. Common neurological symptoms of canine distemper include convulsions, tremors, unsteady gait, and neck stiffness. 1. Convulsions: A typical symptom of canine distemper. After a dog is infected with the virus, the virus attacks nerve cells and interferes with nerve conduction, leading to convulsions. 2. Tremors: Sick dogs will experience muscle tremors, especially in the head and limbs. 3. Unsteady gait: Because the viral infection interferes with the nerve signals for balance and coordination, the animal cannot walk normally. 4. Neck stiffness: Because the virus attacks the nerve cells in the brain and spinal cord, the muscles become stiff, making it impossible for the animal to move freely.

[0003] In recent years, the incidence and mortality of canine distemper have been on the rise, with both rates being even higher in non-immune animals. Currently, there is no specific treatment for the disease, and clinical treatment primarily involves antiviral drugs, antipyretic drugs, and antibiotics combined with interferon, but these treatments are not ideal and cannot completely cure the disease. Therefore, developing a traditional Chinese medicine composition specifically for treating neurological symptoms of canine distemper is of great practical significance.

[0004] In view of this, the present invention is proposed. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating neurological symptoms canine distemper and a preparation method thereof; the traditional Chinese medicine composition for treating neurological symptoms canine distemper solves the problem that neurological symptoms canine distemper is difficult to treat and cannot be cured.

[0006] In order to overcome the deficiencies of the prior art, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine composition for treating canine distemper with neurological symptoms, comprising the following raw medicinal materials in parts by weight:

[0008] 5-10 portions of donkey hide gelatin (such as 5 portions, 6 portions, 7 portions, 8 portions, 9 portions, 10 portions), 2-20 portions of tortoise glue (such as 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions, 8 portions, 9 portions, 10 portions, 11 portions, 12 portions, 13 portions, 14 portions, 15 portions, 16 portions, 17 portions, 18 portions, 19 portions, 20 portions), 2-10 portions of turtle shell glue (such as 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions, 8 portions, 9 portions, 10 portions), 2-10 portions of white atractylodes (such as 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions, 8 portions, 9 portions, 10 portions), 2-10 portions of ophiopogon (such as 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions, 8 portions, 9 portions, 10 portions), 5-15 parts (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-15 parts (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-15 parts (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-15 parts (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-15 parts (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-15 parts of calamus (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts), 5-10 parts of wolfberry (such as 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), 2-10 parts of dodder seed (such as 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), 2-10 parts of drynaria (such as 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), 2-10 parts of epimedium (such as 2 parts, 3 parts, 4 parts, 5 parts, , 6, 7, 8, 9, 10 parts), oyster powder 5-10 parts (such as 5, 6, 7, 8, 9, 10 parts), magnetite 5-15 parts (such as 5, 6, 7, 8, 9, 10 parts, 11, 12, 13, 14, 15 parts), scutellaria 1-10 parts (such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 parts), earthworm 2-10 parts (such as 2, 3, 4, 5, 6, 7, 8, 9, 10 parts) and roasted licorice root 2-10 parts (such as 2, 3, 4, 5, 6, 7, 8, 9, 10 parts).

[0009] Donkey hide gelatin, Ophiopogon japonicus, tortoise glue and turtle shell glue are the main drugs: nourishing yin and blood, replenishing blood, stopping bleeding, moistening dryness and promoting body fluid; Lycium barbarum, Cuscuta chinensis, Drynaria fortunei and Epimedium are the assistant drugs, which have the functions of replenishing kidney essence, kidney qi, replenishing blood, activating blood circulation and unblocking meridians; according to the principle of water generating wood, liver wind is the imbalance symptom caused by liver blood deficiency and inability of yin and yang to balance, so first replenish kidney essence and qi, then replenish blood and activate blood circulation, to achieve the purpose of nourishing liver blood, and thus achieve the purpose of stopping wind; Atractylodes macrocephala, Poria cocos, ginger, roasted liquorice, Evodia rutaecarpa, Arisaema consanguineum and Acorus calamus are the auxiliary drugs: drying dampness and promoting diuresis, replenishing qi and strengthening spleen, having the effects of dispelling cold and relieving pain, descending adverse qi and stopping vomiting, assisting yang and stopping diarrhea, detoxifying and reducing swelling, dispelling wind and calming the nerves, resolving phlegm and dispersing nodules, and mainly treating nerve paralysis, hemiplegia and convulsions; White peony root, oyster powder, magnet, Scutellaria baicalensis and earthworm are its guiding drugs: they have the effects of clearing away heat, detoxifying and stopping wind, calming the liver and suppressing yang, calming the mind, astringing and solidifying, promoting blood circulation and activating collaterals, and stopping epilepsy and convulsions; therefore, the Chinese medicine composition prepared by the present invention through the specific proportion of donkey-hide gelatin, turtle glue, turtle shell glue, Atractylodes macrocephala, Ophiopogon japonicus, Poria cocos, ginger, Evodia rutaecarpa, Arisaema confusa, Acorus calamus, Lycium barbarum, Cuscuta chinensis, Drynaria fortunei, Epimedium, oyster powder, magnetite, Scutellaria baicalensis, earthworm, white peony root, and roasted liquorice, under the synergistic effect of all components, can calm the liver and suppress yang, stop wind, nourish the liver and kidney, clear away heat and stop convulsions, and has a better therapeutic effect on the neurological symptoms such as muscle twitching, circling, collision, foaming at the mouth, clenched jaw, falling to the ground and convulsions caused by wind-heat internal movement caused by canine distemper, which consumes the body fluid and causes liver wind internal movement, which has better therapeutic effect.

[0010] The design optimization concept of the Chinese medicine composition formula of the present invention is:

[0011] Specifically, from the observation of the pathogenesis of canine distemper, the initial stage of the disease is a transient cold caused by wind and cold, followed by symptoms of wind and heat cold, such as yellow nasal discharge, yellow eye discharge, red papules on the groin skin, body temperature hovering around 40.5-41°C, and gradually the foot pads begin to harden, followed by neurological symptoms such as muscle twitching, tremors, severe opisthotonos, and falling to the ground and convulsions. However, after the neurological symptoms appear, the body temperature of many dogs returns to normal.

[0012] The Traditional Chinese Medicine (TCM) hypothesis states that high fever depletes body fluids, leading to liver blood deficiency and internalized liver wind. This wind initially affects the muscles, causing tremors. As liver blood continues to be depleted, the increasingly severe liver wind enters the marrow, causing opisthotonos and convulsions. Initial observations showed strong similarities between the neurological symptoms of Parkinson's disease in humans and those of canine distemper. The hypothesis was that the TCM pathogenesis in humans mirrors that in dogs, with constant muscle tremors and rhythmic contractions. Therefore, experimental treatments were conducted using herbs used to treat Parkinson's disease. However, the presence of centipedes in a Parkinson's formula was found to have side effects on dogs, so they were removed. Furthermore, multiple herbs, including Atractylodes macrocephala, Poria cocos, ginger, Evodia rutaecarpa, Arisaema consanguineum, and Acorus calamus, were added to the formula. After repeated testing, the resulting TCM combination reduced side effects and demonstrated improved therapeutic efficacy.

[0013] In terms of dosage, the dog should be fed according to a prescription of 150-200 catties body weight. The liquid medicine of a prescription should be boiled into 150-200 ml, and the dog should be orally administered at a rate of 1 ml of decoction per 1 catties body weight, once every 3 hours. The first course of treatment is four times of oral administration. Thereafter, the dog should be orally administered at a rate of 1 ml per 1 catties body weight, 2-3 times a day, for 5-10 days as a course of treatment. This method of administration innovates the intermittent dosing method, which has the advantage of alleviating the side effects of the drug. In addition, the blood concentration of the drug can be maintained at a sustained therapeutic concentration, reducing side effects and increasing the cure rate.

[0014] The conventional effects of the Chinese medicinal materials selected in the present invention are as follows:

[0015] Donkey-hide gelatin: It has a faint odor and a slightly sweet flavor. It nourishes blood and yin, moistens dryness, and stops bleeding. It is used for blood deficiency, sallow complexion, dizziness, palpitations, restlessness, insomnia, and dry cough.

[0016] Turtle glue: sweet; salty; cold, meridians entered: liver; spleen; heart; stomach. Functions and indications: nourishes yin and suppresses yang; nourishes blood and stops bleeding. Mainly used for chronic illness, physical weakness, emaciation, fatigue, night sweats, spontaneous sweating, hematemesis, epistaxis, metrorrhagia, and leukopenia.

[0017] Turtle Shell Glue: Cold in nature, salty in flavor, enters the Lung, Liver, and Kidney meridians, nourishes Yin, replenishes blood, reduces fever, and eliminates blood stasis. It is used to treat hot flashes due to Yin deficiency, persistent malaria, malaria-induced lumps, and swollen and painful hemorrhoids.

[0018] Atractylodes macrocephala: Nature and flavor: bitter, sweet, warm. Enters the spleen and stomach meridians. Functions and indications: Atractylodes macrocephala is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid retention, dizziness and palpitations, edema, spontaneous sweating, and fetal restlessness.

[0019] Ophiopogon japonicus: Sweet, slightly bitter, slightly cold. Enters the Heart, Lung, and Stomach meridians. Functions: Nourishes Yin and produces fluid, moistens the lungs and relieves cough. It is used for symptoms of lung and stomach Yin deficiency, such as thirst, dry cough, and hemoptysis; heart Yin deficiency, such as palpitations and fright, and late-stage fever, where heat damages body fluids.

[0020] Poria: Sweet, bland, neutral in nature. It enters the Heart, Lung, Spleen, and Kidney meridians, dispelling dampness, strengthening the spleen, and calming the mind. It is used for edema, oliguria, phlegm and fluid retention, dizziness and palpitations, spleen deficiency, poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0021] Ginger: Pungent and warm in nature. It enters the lung, stomach, and spleen meridians to dispel cold, warm the middle and stop vomiting, and warm the lungs to stop coughing. It is used for spleen and stomach deficiency and cold, loss of appetite, nausea and vomiting, or vomiting caused by phlegm and fluid, vomiting due to stomach disharmony, cough caused by wind-cold or cold phlegm, colds, aversion to wind and fever, and nasal congestion and headache.

[0022] Evodia rutaecarpa: Pungent, bitter, and warm in nature. It enters the liver, spleen, stomach, and kidney meridians. It dispels cold and relieves pain, calms nausea and vomiting, and boosts yang and stops diarrhea. It is primarily used for headaches associated with the Jueyin meridian, abdominal pain due to cold hernia, beriberi caused by cold and dampness, abdominal pain during menstruation, abdominal distension and pain, vomiting and acid reflux, and diarrhea at dawn.

[0023] Arisaema: Bitter and pungent in nature, warm, and toxic. Enters the Lung, Liver, and Spleen meridians. It dries dampness and resolves phlegm, dispels wind and stops spasms, and relieves swelling. It is used for coughs caused by stubborn phlegm, dizziness due to wind phlegm, phlegm accumulation caused by stroke, facial paralysis, hemiplegia, epilepsy, convulsions, and tetanus. It can be used externally raw to treat carbuncles and snake and insect bites.

[0024] Acorus calamus: Nature and flavor: pungent; warming meridians: heart and stomach. Functions and indications: invigorates the mind and resolves phlegm, invigorates the spleen and calms the mind. Used for coma due to febrile illness, epilepsy, tinnitus, deafness, chest tightness, abdominal distension, loss of appetite, and external treatment of carbuncles, sores, and ringworms.

[0025] White Peony Root: Bitter and sour in flavor, slightly cold in nature, enters the Liver and Spleen Meridians, nourishes blood and regulates menstruation, astringes Yin and stops sweating, softens the liver and relieves pain, and calms Liver Yang. It is used for sallow complexion due to blood deficiency, irregular menstruation, spontaneous sweating, night sweats, flank pain, abdominal pain, cramps in the limbs, headache and dizziness.

[0026] Wolfberry: Wolfberry: Sweet, neutral. Function: Wolfberry: Nourishes the liver, kidneys, and lungs. Wolfberry leaves: Tonifies the body, improves essence, clears heat, and improves eyesight.

[0027] Cuscuta: Spicy and sweet in flavor, neutral in nature, it enters the liver, kidney, and spleen meridians. It nourishes the liver and kidneys, strengthens essence and reduces urination, stabilizes the fetus, improves eyesight, and stops diarrhea. It can be used externally to dispel wind and remove freckles. It is commonly used for liver and kidney deficiency, soreness of the waist and knees, impotence and spermatorrhea, enuresis and frequent urination, kidney deficiency with fetal bleeding, restless fetuses, blurred vision and tinnitus, and diarrhea due to spleen and kidney deficiency. It can also be used externally to treat vitiligo.

[0028] Drynaria fortunei: Bitter, warm. Enters the Kidney and Liver meridians. Tonifies the kidneys and strengthens bones, heals wounds and relieves pain. Used for kidney deficiency, low back pain, tinnitus, deafness, loose teeth, falls, sprains, and fractures. Externally used for alopecia areata and vitiligo.

[0029] Epimedium: pungent, sweet, warm, enters the liver and kidney meridians, replenishes kidney yang, strengthens tendons and bones, and eliminates rheumatism. It is used for impotence and spermatorrhea, weakness of tendons and bones, rheumatic pain, numbness and cramps.

[0030] Oyster powder: Salty, neutral, slightly cold, non-toxic, enters the liver and kidney meridians; astringes yin, suppresses yang, stops sweating, astringes semen, resolves phlegm, and softens hard masses. It treats epilepsy, dizziness, spontaneous sweating, night sweats, spermatorrhea, stranguria, metrorrhagia, leukorrhea, scrofula, and goiters. It is used for palpitations, insomnia, dizziness, tinnitus, scrofula-induced phlegm nodules, masses, spontaneous sweating, night sweats, spermatorrhea, metrorrhagia, and stomachache and acid reflux. Calcined oyster shells are astringent and firming. They are used for spontaneous sweating, night sweats, spermatorrhea, metrorrhagia, and stomachache and acid reflux.

[0031] Magnetite: Salty and cold. Enters the Liver, Heart, and Kidney meridians. It calms the nerves, soothes the liver and suppresses yang, improves hearing and eyesight, and promotes qi circulation and relieves asthma. It is used for palpitations, insomnia, dizziness, blurred vision, tinnitus, deafness, and asthma due to kidney deficiency.

[0032] Scutellaria baicalensis: Bitter in flavor, cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It clears heat and dampness, purges fire and detoxifies, stops bleeding, and stabilizes the fetus. It is used for damp-heat syndrome, summer heat dampness, chest tightness and nausea, damp-heat fullness and distension, diarrhea, jaundice, lung-heat cough, high fever and thirst, vomiting and epistaxis due to blood heat, carbuncles, sores, and fetal restlessness.

[0033] Earthworm: salty in taste, cold in nature, enters the liver, spleen, and bladder meridians, has the effects of clearing heat and calming the nerves, unblocking meridians, relieving asthma, and promoting diuresis. It is mainly used to treat high fever and coma, epilepsy and convulsions, joint pain, limb numbness, edema and oliguria, etc.

[0034] Roasted Licorice: Sweet, neutral, soothing, moistening the lungs, detoxifying, and harmonizing various herbs. Roasted, it treats spleen and stomach deficiency, poor appetite, abdominal pain and loose stools, fatigue and fever, lung atrophy and cough, palpitations, and epilepsy. Raw, it treats sore throat, peptic ulcers, carbuncles, and ulcers, and detoxifies drug and food poisoning.

[0035] The weight parts described in the present invention mainly include the disclosed numerical ranges, any numerical value (including integers and decimals) or the interval between any two numerical values ​​within the disclosed range, or multiple discontinuous intervals, and also include numerical values ​​or numerical ranges close to the end values ​​of the numerical ranges whose effects can be expected to be similar, for example, 5-10 parts, not only include 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and the interval between any two parts, for other numerical ranges, not exemplified one by one, all are included in the present invention. Therefore, the present invention also includes subranges of any numerical range that has been directly disclosed or any specific numerical value therein.

[0036] In order to further optimize the efficacy of the traditional Chinese medicine composition, the present invention studies the influence of different proportions of various raw medicinal materials on the efficacy, and obtains respectively better and more optimal proportions of the traditional Chinese medicine composition, wherein the better proportion of the traditional Chinese medicine composition is: 6-9 parts of donkey-hide gelatin, 6-16 parts of tortoise glue, 4-8 parts of turtle shell glue, 4-8 parts of white atractylodes, 4-8 parts of ophiopogon, 8-12 parts of white peony root, 8-12 parts of poria, 8-12 parts of ginger, 8-12 parts of evodia rutaecarpa, 8-12 parts of arisaema, 8-12 parts of calamus, 6-9 parts of wolfberry, 4-8 parts of dodder seed, 4-8 parts of drynaria, 4-8 parts of epimedium, 6-9 parts of oyster powder, 8-12 parts of magnetite, 3-8 parts of scutellaria, 4-8 parts of earthworm and 4-8 parts of roasted liquorice.

[0037] A better ratio of the traditional Chinese medicine composition is: 7.5 parts of donkey-hide gelatin, 11 parts of tortoise glue, 6 parts of turtle shell glue, 6 parts of Atractylodes macrocephala, 6 parts of Ophiopogon japonicus, 10 parts of White Peony Root, 10 parts of Poria cocos, 10 parts of ginger, 10 parts of Evodia rutaecarpa, 10 parts of Arisaema, 10 parts of Acorus calamus, 7.5 parts of Lycium barbarum, 6 parts of Cuscuta australis, 6 parts of Drynaria fortunei, 6 parts of Epimedium, 7.5 parts of oyster powder, 10 parts of magnetite, 5.5 parts of Scutellaria baicalensis, 6 parts of earthworm and 6 parts of roasted licorice.

[0038] In addition, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0039] S1. Weigh all the raw medicinal materials by weight, except for donkey-hide gelatin, tortoise glue, and turtle shell glue, mix the remaining medicinal materials evenly, and soak them in water for 1 to 2 hours;

[0040] S2, boiling the raw medicinal materials and the soaking liquid soaked in step S1 for the first time, filtering to obtain the primary decoction and medicinal residue;

[0041] S3, adding water to the medicinal residue obtained in step S2 for a second decoction, and filtering to obtain a secondary decoction liquid;

[0042] S4. Combine the first decoction and the second decoction, add donkey-hide gelatin, tortoise glue and turtle shell glue and wait for them to melt to obtain a decoction of a Chinese medicinal composition for treating canine distemper with neurological symptoms.

[0043] In the above preparation method, as a preferred embodiment, in step S1, the amount of water is 8 to 10 times (including 8 times, 9 times, and 10 times) the weight of the raw medicinal material.

[0044] In the above preparation method, as a preferred embodiment, in step S2, the first decoction includes first boiling with high heat and then decocting with low heat for 1.5 to 2 hours (including 1.5 hours, 1.6 hours, 1.7 hours, 1.8 hours, 1.9 hours, and 2 hours).

[0045] In the above preparation method, as a preferred embodiment, in step S3, the amount of water is 8 to 10 times (including 8 times, 9 times, and 10 times) the weight of the medicinal residue.

[0046] In the above preparation method, as a preferred embodiment, in step S3, the second decoction includes first boiling with high heat and then decocting with low heat for 1.5 to 2 hours (including 1.5 hours, 1.6 hours, 1.7 hours, 1.8 hours, 1.9 hours, and 2 hours).

[0047] In addition, the present invention also provides the use of the above-mentioned traditional Chinese medicine composition in preparing a drug for treating neurological symptoms of canine distemper.

[0048] The present invention also includes combined medications that can be anticipated by those skilled in the art, for example, the Chinese medicine composition for treating neurological symptoms of canine distemper of the present invention is used while taking other drugs orally.

[0049] Clinical effect of the Chinese herbal composition of this decoction: Through more than 10 years of clinical treatment attempts, it was found that it has a clinical therapeutic effect on more than 80% of the mental symptoms caused by canine distemper. Some dogs will experience vomiting symptoms after taking this decoction, which is related to the taste of the medicine.

[0050] Compared with the prior art, the technical solution of the present invention has at least the following technical effects:

[0051] The traditional Chinese medicine composition for treating canine distemper with neurological symptoms can calm the liver and suppress yang, calm wind, nourish the liver and kidneys, clear away heat and calm convulsions, and has a better therapeutic effect on the neurological symptoms of canine distemper caused by internal movement of wind and heat, which consumes body fluid and causes internal movement of liver wind, such as muscle twitching, circling, colliding, foaming at the mouth, clenched jaws, falling to the ground and convulsions. DETAILED DESCRIPTION

[0052] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0053] Example 1

[0054] This embodiment provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0055] Donkey-hide gelatin 7.5g, tortoise glue 11g, turtle shell glue 6g, Atractylodes macrocephala 6g, Ophiopogon japonicus 6g, White Peony Root 10g, Poria 10g, Ginger 10g, Evodia rutaecarpa 10g, Arisaema 10g, Acorus calamus 10g, Lycium barbarum 7.5g, Cuscuta chinensis 6g, Drynaria fortunei 6g, Epimedium 6g, Oyster powder 7.5g, Magnetite 10g, Scutellaria baicalensis 5.5g, Earthworm 6g, Roasted Licorice Root 6g.

[0056] The preparation method of the Chinese medicine composition of this embodiment is as follows:

[0057] Weigh all the raw medicinal materials according to the above-mentioned parts by weight, and mix the remaining medicinal materials except donkey-hide gelatin, tortoise glue and turtle shell glue evenly, then add water to soak for 2 hours, and the amount of water added is 8 times the total weight of the medicinal materials; then perform the first decoction, first use high heat to decoct, and after the medicinal soup boils, use low heat to decoct for 1.5 hours, filter, retain the medicinal liquid, add the above-mentioned equal amount of water to the medicinal residue and perform the second decoction, the second decoction process is the same as the first decoction, then filter, decoct the medicinal liquid, combine the two medicinal liquids, add donkey-hide gelatin, tortoise glue and turtle shell glue and wait for them to melt to obtain a decoction of Chinese medicinal composition for treating neurological symptoms of canine distemper, wait for it to cool, and give it to the sick dog orally.

[0058] Example 2

[0059] This embodiment provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0060] Donkey-hide gelatin 5g, tortoise glue 2g, turtle shell glue 2g, Atractylodes macrocephala 2g, Ophiopogon japonicus 2g, White Peony Root 5g, Poria 5g, Ginger 5g, Evodia rutaecarpa 5g, Arisaema 5g, Acorus calamus 5g, Lycium barbarum 5g, Cuscuta chinensis 2g, Drynaria fortunei 2g, Epimedium 2g, Oyster powder 5g, Magnetite 5g, Scutellaria baicalensis 1g, Earthworm 2g, Roasted Licorice 2g.

[0061] The preparation method of the Chinese medicine composition of this embodiment is the same as that of Example 1.

[0062] Example 3

[0063] This embodiment provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0064] Donkey-hide gelatin 10g, tortoise glue 20g, turtle shell glue 10g, Atractylodes macrocephala 10g, Ophiopogon japonicus 10g, White Peony 15g, Poria 15g, Ginger 15g, Evodia rutaecarpa 15g, Arisaema 15g, Acorus calamus 15g, Lycium barbarum 10g, Cuscuta chinensis 10g, Drynaria fortunei 10g, Epimedium 10g, Oyster powder 10g, Magnetite 15g, Scutellaria baicalensis 10g, Earthworm 10g, Roasted Licorice root 10g.

[0065] The preparation method of the Chinese medicine composition of this embodiment is the same as that of Example 1.

[0066] Example 4

[0067] This embodiment provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0068] Donkey-hide gelatin 6g, tortoise glue 6g, turtle shell glue 4g, Atractylodes macrocephala 4g, Ophiopogon japonicus 4g, White Peony 8g, Poria 8g, Ginger 8g, Evodia rutaecarpa 8g, Arisaema 8g, Acorus calamus 8g, Lycium barbarum 6g, Cuscuta chinensis 4g, Drynaria fortunei 4g, Epimedium 4g, Oyster powder 6g, Magnetite 8g, Scutellaria baicalensis 3g, Earthworm 4g, Roasted Licorice root 4g.

[0069] The preparation method of the Chinese medicine composition of this embodiment is the same as that of Example 1.

[0070] Example 5

[0071] This embodiment provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0072] Donkey-hide gelatin 9g, tortoise glue 16g, turtle shell glue 8g, Atractylodes macrocephala 8g, Ophiopogon japonicus 8g, White Peony 12g, Poria 12g, Ginger 12g, Evodia rutaecarpa 12g, Arisaema 12g, Acorus calamus 12g, Lycium barbarum 9g, Cuscuta chinensis 8g, Drynaria fortunei 8g, Epimedium 8g, Oyster powder 9g, Magnetite 12g, Scutellaria baicalensis 8g, Earthworm 8g, Roasted Licorice root 8g.

[0073] The preparation method of the Chinese medicine composition of this embodiment is the same as that of Example 1.

[0074] Comparative Example 1

[0075] This comparative example provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0076] Atractylodes macrocephala 6g, Ophiopogon japonicus 6g, Poria cocos 10g, Ginger 10g, Evodia rutaecarpa 10g, Arisaema consanguineum 10g, Acorus calamus 10g, Lycium barbarum 7.5g, Cuscuta chinensis 6g, Drynaria fortunei 6g, Epimedium 6g, Scutellaria baicalensis 5.5g, Roasted Licorice root 6g.

[0077] The preparation method of the Chinese medicine composition of this comparative example is the same as that of Example 1.

[0078] Comparative Example 2

[0079] This comparative example provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0080] Donkey-hide gelatin 7.5g, tortoise glue 11g, turtle shell glue 6g, Ophiopogon japonicus 6g, White Peony 10g, Lycium barbarum 7.5g, Cuscuta chinensis 6g, Drynaria fortunei 6g, Epimedium 6g, oyster powder 7.5g, magnetite 10g, Scutellaria baicalensis 5.5g, earthworm 6g.

[0081] The preparation method of the Chinese medicine composition of this comparative example is the same as that of Example 1.

[0082] Comparative Example 3

[0083] This comparative example provides a traditional Chinese medicine composition for treating canine distemper with neurological symptoms, and the weight proportions of the raw medicinal materials are as follows:

[0084] Donkey-hide gelatin 7.5g, tortoise glue 11g, turtle shell glue 6g, Atractylodes macrocephala 6g, Ophiopogon japonicus 6g, White Peony Root 10g, Poria 10g, Ginger 10g, Evodia rutaecarpa 10g, Arisaema 10g, Acorus calamus 10g, Lycium barbarum 7.5g, Cuscuta chinensis 6g, Drynaria fortunei 6g, Epimedium 6g, Oyster powder 7.5g, Magnetite 10g, Scutellaria baicalensis 5.5g, Earthworm 6g, Roasted Licorice Root 6g, 4.5 parts of scorpion, 2 parts of centipede, and 4.5 parts of fleabane.

[0085] The preparation method of the Chinese medicine composition of this comparative example is the same as that of Example 1.

[0086] In order to demonstrate the effect of the Chinese medicine composition for treating neurological symptoms of canine distemper of the present invention, the following typical cases are selected for illustration: wherein the Chinese medicine composition taken is the decoction prepared in Example 1.

[0087] Case 1:

[0088] Golden Retriever, 80 days old, 40 catties in weight, coughed, had a runny nose, and had muscle tremors. The dog's limbs kept shaking up and down. The body temperature was 38.5 degrees at 9 o'clock in the morning. It came to the pet clinic for treatment. The Korean Anjie Canine Distemper Detection Card tested it as a weak positive for canine distemper. The tongue coating was white, and there were ecchymosis on the edge of the tongue tip. It ate and drank normally. It had been treated in other pet clinics a few days ago with fever, cough, and runny nose. After treatment, the above neurological symptoms appeared before coming to this clinic, 7-8 times a day. The dog's expression was very painful and it kept roaring.

[0089] Diagnosis: Neurological symptoms caused by canine distemper. Use the above scheme to orally administer 40ml at a time, once every 3 hours, and 4 times for a course of treatment. The first two doses of the liquid were orally administered in this clinic, and the next two doses were orally administered at home. The frequency and strength of the muscle twitching after medication were observed. The next day, the patient came back for a follow-up visit and described that after taking the medicine twice more at an interval of 3 hours after returning home, the muscle twitched 3 times, and the frequency of each time was much smaller than before. The patient came back for a follow-up visit at 10 am the next day, and no convulsions were found. The dosage of the medicine on the second day was 40ml, administered 4 times a day. Take enough medicine for three days and take it home for self-administration.

[0090] Three days later, the dog was referred for a follow-up visit. The dog had a convulsion on the second night, which disappeared within a few minutes. No convulsions were observed on the third day, nor on the fourth day. On the fifth day, the dog was in good spirits, with a pale tongue coating and no ecchymosis on the edge of the tongue. Its temperature was 38.5 degrees Celsius at 9 a.m. Considering that the clinical symptoms had disappeared, but to prevent recurrence, the dog was prescribed the drug twice a day for another five days, 40 ml at a time. Five days later, the dog was referred for a follow-up visit. No recurrence of convulsions was observed, and the drug was discontinued. Contact information was provided for future inquiries. Three months later, the dog was called again and found to be in good health, with no recurrence of convulsions. The dog had grown to a weight of about 60 kilograms and regularly went fishing with its owner. Its vital signs were normal. Six months later, the dog was referred for inquiries, and the results were the same as at three months.

[0091] Case 2:

[0092] A 5-year-old Pekingese dog weighing 12 catties came to the clinic and reported that he had suddenly fallen to the ground and convulsed for no reason a few days ago, with foaming at the mouth and opisthotonos, which lasted for about 5 minutes. He then regained consciousness and had the disease 4 times a day. The Korean Anjie Canine Distemper Detection Card tested positive for canine distemper. The dog owner originally came to the store for euthanasia, but after clinical analysis and introduction, he agreed to try the above-mentioned Chinese medicine formula for treating neurological canine distemper. The feeding dose for a 12-catties dog is 12 ml, and it should be administered orally once every three hours. A daily dose should be taken to observe the evolution of the disease. The dog was administered orally once in the store, and the owner administered the other three doses of medicine at home by himself. During the follow-up visit the next day, it was learned that it was already 5 pm when the dog went home to take the medicine. He had a convulsion during the administration of the medicine. After administering the medicine four times, he had an attack around 8 pm, which was shortened by 2 minutes. The symptoms of the disease were significantly relieved.

[0093] The second day's medication was the same as the first day's, and the dog was fed for two consecutive days to observe the situation. On the fourth day, the dog was found to have only one seizure on the second day, which lasted for one minute. On the third day, the dog had one seizure as well. The owner did not see how long it lasted, as the dog would get up again as soon as it lay down. The dog was in good spirits, so the dog was given the drug for another three days, three times a day, 15 ml each time. When the dog was re-evaluated, the seizure stopped on the second day of the medication, and the dog has not had a seizure for a day. Considering the prevention of recurrence, the dog was prescribed a 6-day dose, a total of 10 days of medication. After 6 days of follow-up, it was learned that no convulsion symptoms were found with the 6-day dose, and the dog's mental state and appetite had improved greatly. A course of treatment was 10 days, and it was decided to stop the medication and go home for observation. One month later, the dog owner came for a follow-up visit again, describing the mild convulsion symptoms found yesterday, which were not serious, and asked whether to feed the drug again. Considering the recurrence of the neurological symptoms of canine distemper, it was recommended that the dog owner take a 10-day dose and take another course of treatment. The dog owner agreed. After a follow-up visit 10 days later, the dog had no convulsion symptoms, and all vital signs were normal, so the medication was stopped for recuperation. Six months later, the dog was checked by phone and everything was normal, with no convulsion symptoms.

[0094] Case 3:

[0095] Teddy dog, male, weighing 10 catties, 5 years old, with a body temperature of 38.5 degrees, came to the clinic to tell the story that he forgot to take the canine distemper vaccine, which caused canine distemper pneumonia. After treatment, about 10 days after the pneumonia recovered, the dog developed neurological symptoms of muscle tremors and fell to the ground, became unconscious, foamed at the mouth, and had paddling convulsions of his limbs, each lasting for 2 minutes, twice a day. The duration has been longer in recent days. The dog is now listless, has a decreased appetite, is unable to walk, has a white tongue coating, and ecchymosis appears on the edge of the tongue. He came to the clinic to measure his body temperature at 38.5 degrees at 9 am. He heard that our clinic can treat neurological symptoms of canine distemper, so he came to try it.

[0096] Clinical analysis, from the clinical symptoms, muscle diagnosis and epilepsy occurred at the same time, liver wind in the muscles and brain, this situation is serious, get the dog owner's consent, 10 days of treatment to see how effective it is. On the first day, take 10 ml of the above-mentioned liquid orally each time, once every 3 hours, take it orally 5 times on the same day, and then go back for a follow-up visit on the second day to report that the muscle tremor symptoms disappeared, and the latter epilepsy symptoms were relieved. The dog's mental symptoms improved, appetite improved, and it ate something to see if its symptoms were relieved. It is recommended that the dosage for the second to fifth days should be the same as the dosage for the first day. When it came back for a follow-up visit on the sixth day, it was reported that the epilepsy symptoms had been relieved a lot, and the duration was shortened by about 1 minute. The dog's appetite and spirit returned to normal, and then the dosage for 6-10 days was changed to 3 times a day, 10 ml each time. After 10 days, the dog was re-examined. After the 8th day, the epilepsy symptoms disappeared, and the dog had a good appetite and spirit. Considering that the symptoms had basically disappeared, the bruises on the edge of the tongue disappeared, and the medication was stopped and the dog went home to recuperate. Two months later, the dog came back for a follow-up visit. Because the dog owner hit the dog, it was found that the dog had epileptic symptoms again the next day, which lasted for about 1 minute. Considering that the dog had another attack due to external stimulation, bruises appeared on the edge of the dog's tongue, and the liver wind entered the brain again, it was recommended that this course of treatment is also 10 days. The dosage for the first 4 days is 10ml / time orally every 3 hours, and the dosage for the next 7 days is 10ml / time orally 3 times a day. Take the dosage for three days first and observe the situation. After three days of taking it, the epilepsy of about 1 minute disappeared. After the follow-up visit, it was found that the bruises on the edge of the dog's tongue disappeared, and the remaining 7-day dosage was enough. After a follow-up examination at the clinic 10 days later, all the symptoms disappeared, and the dog went home to recuperate, and was advised not to over-stimulate the dog. After 3 months, a phone call was made to inquire, and the dog had no recurrence of symptoms and all vital signs were normal.

[0097] Observation on clinical feeding experiment of clinical control group

[0098] Control group 1:

[0099] The decoction of the Chinese medicine composition prepared in Comparative Example 1 was given to 8 dogs weighing 8 to 60 kilograms with neurological symptoms of canine distemper at different time periods. It was found that after drinking the decoction, the symptoms of 7 dogs did not improve, but worsened, and the number of convulsions and duration became longer. Although the convulsion symptoms of one dog improved a little, after a few days, the symptoms began to worsen again. As the dog's condition prolonged, the symptoms became more and more serious.

[0100] Control group 2:

[0101] The decoction of the Chinese medicine composition prepared in Comparative Example 2 was given to 8 dogs weighing 10-40 catties with neurological symptoms of canine distemper at different time periods. It was found that although the neurological symptoms of 5 dogs improved, the improvement of the symptoms was relatively slow. The symptoms stabilized only after taking the medicine for 4 weeks. The symptoms of the remaining 3 dogs showed clinical symptoms that were sometimes good and sometimes bad.

[0102] Control group 3:

[0103] Before obtaining the component formula of the present invention, the inventor initially tried the formula of the component ratio of Comparative Example 3. After the formula of Comparative Example 3 was decocted in the same way, 10 dogs with neurological symptoms and canine distemper symptoms at different stages were fed with the medicine at a dose of 1 ml per 1 catties of body weight and once every 3 hours. It was found that after taking the medicine, although the neurological symptoms of the 10 dogs disappeared, all of them had loss of appetite, low body temperature, and increased vomiting. Six dogs had diarrhea to varying degrees, weakness in the limbs, and obvious drowsiness, and suspected symptoms of poisoning appeared. After the three medicinal materials of 4.5 parts of scorpion, 2 parts of centipede, and 4.5 parts of fleawort were removed through prescription analysis, the above-mentioned suspected poisoning symptoms did not appear.

[0104] Control group 4:

[0105] A 3-month-old dachshund weighing 5 catties developed neurological muscle twitching symptoms after canine distemper pneumonia, with a body temperature of 38.8 degrees and a normal appetite. The dog had 3 attacks a day, each lasting about 4 minutes. There were ecchymosis on the edge of the tongue. It was recommended to use the above-mentioned Chinese medicine composition for treatment, but the dog owner insisted on taking Angong Niuhuang Pills. As the dog owner could not be persuaded, it was suggested that he divide Angong Niuhuang Pills into 10 portions and feed one portion at a time, once a day, for 10 days to see the effect. After 10 days, he called to inquire. After taking it for 5 days, the muscle twitching symptoms were relieved. After 8 days, the symptoms began to rebound. On the 9th day, the muscle twitching symptoms became serious and epilepsy symptoms appeared. The dog was not seen at night, but was found dead the next morning with opisthotonos. The dog owner regretted not using the clinic's Chinese medicine composition to treat neurological symptoms of canine distemper.

[0106] The above describes and evaluates the efficacy of some embodiments of the present invention. It should be understood that the present invention is not limited to the above-mentioned specific embodiments. Any person skilled in the art can use the above-mentioned disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments with equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solutions of the present invention are still within the scope of protection of the technical solutions of the present invention.

Claims

1. A Chinese medicine composition for treating neurological symptoms of canine distemper, characterized in that: Made from the following raw medicinal materials in parts by weight: 5-10 parts of donkey-hide gelatin, 2-20 parts of tortoise shell glue, 2-10 parts of turtle shell glue, 2-10 parts of Atractylodes macrocephala, 2-10 parts of Ophiopogon japonicus, 5-15 parts of white peony root, 5-15 parts of Poria cocos, 5-15 parts of ginger, 5-15 parts of Evodia rutaecarpa, 5-15 parts of Arisaema consanguineum, 5-15 parts of Acorus calamus, 5-10 parts of Lycium barbarum, 2-10 parts of Cuscuta australis, 2-10 parts of Drynaria fortunei, 2-10 parts of Epimedium, 5-10 parts of oyster powder, 5-15 parts of magnetite, 1-10 parts of Scutellaria baicalensis, 2-10 parts of earthworm and 2-10 parts of roasted liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that Made from the following raw medicinal materials in parts by weight: 6-9 parts of donkey-hide gelatin, 6-16 parts of tortoise shell glue, 4-8 parts of turtle shell glue, 4-8 parts of Atractylodes macrocephala, 4-8 parts of Ophiopogon japonicus, 8-12 parts of White Peony Root, 8-12 parts of Poria cocos, 8-12 parts of ginger, 8-12 parts of Evodia rutaecarpa, 8-12 parts of Arisaema, 8-12 parts of Acorus calamus, 6-9 parts of Lycium barbarum, 4-8 parts of Cuscuta australis, 4-8 parts of Drynaria fortunei, 4-8 parts of Epimedium, 6-9 parts of oyster powder, 8-12 parts of magnetite, 3-8 parts of Scutellaria baicalensis, 4-8 parts of earthworm, and 4-8 parts of roasted liquorice.

3. The Chinese medicine composition according to claim 1, characterized in that Made from the following raw medicinal materials in parts by weight: 7.5 parts of donkey-hide gelatin, 11 parts of tortoise shell glue, 6 parts of turtle shell glue, 6 parts of Atractylodes macrocephala, 6 parts of Ophiopogon japonicus, 10 parts of White Peony Root, 10 parts of Poria cocos, 10 parts of ginger, 10 parts of Evodia rutaecarpa, 10 parts of Arisaema, 10 parts of Acorus calamus, 7.5 parts of Lycium barbarum, 6 parts of Cuscuta australis, 6 parts of Drynaria fortunei, 6 parts of Epimedium, 7.5 parts of oyster powder, 10 parts of magnetite, 5.5 parts of Scutellaria baicalensis, 6 parts of earthworm and 6 parts of roasted liquorice.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Weigh all the raw medicinal materials by weight, except for donkey-hide gelatin, tortoise glue, and turtle shell glue, mix the remaining medicinal materials evenly, and soak them in water for 1-2 hours; S2, boiling the raw medicinal materials and the soaking liquid soaked in step S1 for the first time, filtering to obtain the primary decoction and medicinal residue; S3, adding water to the medicinal residue obtained in step S2 for a second decoction, and filtering to obtain a secondary decoction liquid; S4. Combine the first decoction and the second decoction, add donkey-hide gelatin, tortoise glue and turtle shell glue and wait for them to melt to obtain a decoction of a Chinese medicinal composition for treating canine distemper with neurological symptoms.

5. The preparation method according to claim 4, characterized in that In step S1, the amount of water is 8 to 10 times the weight of the raw medicinal material.

6. The preparation method according to claim 4, characterized in that In step S2, the first decoction includes first boiling with high heat and then decocting with low heat for 1.5 to 2 hours.

7. The preparation method according to claim 4, characterized in that In step S3, the amount of water is 8 to 10 times the weight of the medicinal residue.

8. The preparation method according to claim 4, characterized in that In step S3, the second decoction includes first boiling with high heat and then decocting with low heat for 1.5 to 2 hours.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in preparing a drug for treating neurological symptoms of canine distemper.