A composition having a breast enhancing effect

Abstract

The application discloses a composition with breast augmentation effect and a preparation process. The composition is an oral preparation prepared from the following raw materials in parts by weight: 25-35 parts of rhizoma polygonati, 7-13 parts of vigna radiata, 10-20 parts of coix seed, 2-8 parts of mentha, 12-18 parts of dioscorea, 3-7 parts of amomum tsao-ko, 10-15 parts of lily, 25-35 parts of carica papaya, 12-18 parts of platycodon grandiflorum, 2-7 parts of bergamot, and 2-7 parts of ganoderma. The composition has the breast augmentation effect, and has the excellent taste without adding the auxiliary materials, improves the compliance of the puerpera, and has the clinical application value.

Description

A composition with emulsifying effect Technical Field

[0001] This invention specifically relates to a composition having a milk-enhancing effect. Background Technology

[0002] Since ancient times, breast milk has been considered the ideal natural food for infants, its nutritional content unmatched by any processed food. If, more than a week after delivery, insufficient lactation or obstructed milk flow occurs, resulting in very little or no milk, this is called "insufficient lactation," also known as "postpartum milk insufficiency" or "lack of milk." The main causes of insufficient lactation in postpartum women include: psychological factors that inhibit the secretion of prolactin from the pituitary gland, thus affecting lactation; changes in diet, such as overnutrition, unbalanced diets, dieting, or excessive consumption of fruits and vegetables, leading to a deficiency of protein, fat, and other nutrients, thus reducing milk production; work stress, working during the day and breastfeeding at night, resulting in insufficient sleep and increased fatigue; and incorrect understanding of pregnancy and childbirth, such as concerns about breastfeeding affecting physical appearance, leading to reduced feeding frequency. These factors contribute to insufficient milk production in many postpartum women.

[0003] For postpartum women with insufficient breast milk, Traditional Chinese Medicine (TCM) offers various treatments, including: ① external application, such as applying a hot compress to the breasts with a towel or gauze soaked in orange peel extract; ② dietary therapy, such as decocting pig's trotters, octopus, angelica root, and wolfberry in water and consuming it; ③ acupuncture, such as applying vaccaria seeds to acupoints related to the endocrine system, breast, and pituitary gland; and ④ massage. These methods all have drawbacks. For example, external application, massage, and acupuncture can cause breast discomfort in postpartum women, and the addition of medicinal herbs to dietary therapy can result in poor taste and affect the mother's appetite. Currently, many traditional Chinese medicine formulas are being prepared into modern preparations. For example, patent CN200610046009.1 discloses a traditional Chinese medicine for treating postpartum hypogalactia, agalactia, and blocked milk ducts. It is an oral preparation made with traditional Chinese medicinal materials as the main ingredient and added excipients. It increases breast milk production after postpartum women take it and improves the taste, making it easier for them to accept. However, because the bitterness of the traditional Chinese medicine needs to be masked with excipients, the production cost is increased, making it difficult to promote and apply industrially. In addition, since it is a traditional Chinese medicine preparation, it is not easy for postpartum women to accept it due to concerns about the health of infants. Summary of the Invention

[0004] To address the above problems, the present invention provides a composition with a milk-enhancing effect, which is an oral preparation made from the following raw materials in parts by weight:

[0005] Polygonatum 25-35 parts, red adzuki bean 7-13 parts, coix seed 10-20 parts, mint 2-8 parts, yam 12-18 parts, cardamom 3-7 parts, lily 10-15 parts, papaya 25-35 parts, platycodon 12-18 parts, citron 2-7 parts, and ganoderma 2-7 parts.

[0006] Furthermore, it is an oral preparation made from the following raw materials in parts by weight:

[0007] 30 parts Polygonatum, 10 parts red adzuki bean, 15 parts coix seed, 5 parts mint, 15 parts yam, 10 parts cardamom, 15 parts lily, 30 parts papaya, 15 parts platycodon, 5 parts citron, and 5 parts Ganoderma lucidum.

[0008] Furthermore, the method for preparing the oral formulation is as follows:

[0009] 1) Take peppermint, cardamom, lily, papaya, platycodon, citron and lingzhi, add water to extract, concentrate the extract, dry to obtain dried powder A; dry the raw material residue, pulverize and sieve to obtain dried powder B;

[0010] 2) Take Polygonatum sibiricum, red adzuki bean, coix seed and yam, dry and grind them, sieve them to obtain dry powder C;

[0011] 3) Take the dried powder A and dried powder B from step 1) and mix them with the dried powder C from step 2) to obtain the final product.

[0012] Further, the extraction described in step 1) is a decoction extraction. Before decoction, the ingredients are soaked for 15 minutes and then decocted for 30 minutes. The decoction is repeated 3 times, and the amount of water added each time is 10 times that of the raw material, w / w.

[0013] Further, the concentration in step 1) is vacuum concentration at a temperature of 60°C and a vacuum degree of 0.08 MPa; the concentrate obtained by vacuum concentration is spray dried, with a feed temperature of 50-60°C, an air inlet temperature of 185-195°C, and an air outlet temperature of 95-105°C; the relative density of the concentrate is 1.08-1.10.

[0014] Further, in step 1), the raw material residue is first heated and dried at 110°C for 30 minutes, and then heated and dried at 80°C for 90 minutes; the sieving is done through a 100-mesh sieve.

[0015] Further, in step 2), the drying temperature is 110°C and the time is 2 hours, and the sieving is done through a 100-mesh sieve.

[0016] The present invention also provides the use of the aforementioned composition in the preparation of a medicament having a milk-enhancing effect.

[0017] Finally, this invention provides the use of the aforementioned composition in the preparation of food products that promote lactation.

[0018] Furthermore, the food is a health food; the health food is a food with health-preserving effects.

[0019] In the composition for promoting lactation of the present invention, polygonatum has the effects of tonifying the spleen and replenishing qi, moistening the lungs and promoting the production of body fluid; Chinese yam has the functions of replenishing qi in the middle-jiao, nourishing yin and calming the mind, and tonifying the kidney; lily has the effect of nourishing yin and moistening the lungs and promoting the production of body fluid; the combination of the three can reach the effect of invigorating the spleen, replenishing qi and nourishing yin, promoting the production of body fluid, replenishing the source of milk production, and increasing milk, thus being the monarch drug. Carica papaya can invigorate the spleen and promote digestion. It is recorded in "Modern Practical Chinese Medicine" that "the juice of unripe fruits can treat gastric indigestion, and is also a nutritional product and a lactagogue", and it has the effect of promoting milk secretion; adzuki bean can promote diuresis and alleviate edema; coix seed can invigorate the spleen, promote diuresis, and alleviate edema through dampness elimination; tsaoko fruit can dry dampness and dispel cold, invigorate the spleen and promote appetite, and alleviate edema; the combination of the four drugs can reach the effect of invigorating the spleen and promoting diuresis and promoting milk secretion, thus being the ministerial drug. Fructus Citri Sarcodactylis can soothe the liver and invigorate the spleen, regulate qi and resolve phlegm; Mentha haplocalyx can soothe the liver and invigorate the spleen, regulate qi and open the orifices; Ganoderma lucidum can replenish qi and calm the mind; the combination of the three can promote milk secretion and is the adjuvant drug. Platycodon grandiflorum can promote the lung qi and help all the drugs ascend to the breast to promote milk secretion and is the messenger drug. The combination of all the drugs can reach the effects of invigorating the spleen and soothe the liver, nourishing yin and promoting the production of body fluid, and achieve the effect of promoting milk secretion.

[0020] It has been proved by experiments that the composition of the present invention, through specific Chinese medicinal materials homologous to food and medicine, their dosages and preparation processes, not only has a significant effect on promoting lactation, but also obtains an excellent taste without adding excipients, improves the compliance of parturients, and has the value of clinical popularization and application.

[0021] Obviously, based on the above content of the present invention, according to the common technical knowledge and conventional means in the field, without departing from the above basic technical idea of the present invention, various other forms of modifications, substitutions or changes can be made.

[0022] The following is a further detailed description of the above content of the present invention through specific embodiments in the form of examples. However, this should not be construed as limiting the scope of the above subject matter of the present invention to the following examples. All technologies implemented based on the above content of the present invention fall within the scope of the present invention. Specific Embodiments

[0023] Example 1 Preparation of the Composition for Promoting Lactation of the Present Invention

[0024] Formula: 30 grams of polygonatum, 10 grams of adzuki bean, 15 grams of coix seed, 5 grams of Mentha haplocalyx, 15 grams of Chinese yam, 10 grams of tsaoko fruit, 15 grams of lily, 30 grams of Carica papaya, 15 grams of Platycodon grandiflorum, 5 grams of Fructus Citri Sarcodactylis, 5 grams of Ganoderma lucidum.

[0025] Preparation method:

[0026] 1) Take peppermint, cardamom, lily bulb, papaya, platycodon root, bergamot, and ganoderma, soak them in water for 15 minutes, then decoct for 30 minutes. Decoction is repeated 3 times, with the amount of water added each time being 10 times the total amount of raw materials. Combine the decoctions, filter, and concentrate the filtrate under reduced pressure at 60℃ and 0.08 MPa to a density of 1.08-1.10 (60℃). Spray dry the concentrate at a feed temperature of 50-60℃, an air inlet temperature of 185-195℃, and an air outlet temperature of 95-105℃ to obtain dried powder A. The raw material residue is first dried at 110℃ for 30 minutes, then dried at 80℃ for 90 minutes, pulverized, and passed through a 100-mesh sieve to obtain dried powder B.

[0027] 2) Take Polygonatum sibiricum, red adzuki bean, coix seed and yam, dry at 110℃ for 2 hours, pulverize, pass through a 100-mesh sieve to obtain dried powder C;

[0028] 3) Take the dried powder A and dried powder B from step 1) and mix them with the dried powder C from step 2) to obtain the final product.

[0029] Example 2: Preparation of the composition with emulsifying effect of the present invention

[0030] Formula: 25g Polygonatum sibiricum, 7g red adzuki bean, 10g coix seed, 2g mint, 12g yam, 3g cardamom, 10g lily bulb, 25g papaya, 12g platycodon grandiflorus, 2g citron, 3g Ganoderma lucidum.

[0031] Preparation method: Same as in Example 1.

[0032] Example 3: Preparation of the composition with emulsifying effect of the present invention

[0033] Formula: 35g Polygonatum sibiricum, 13g red adzuki bean, 20g coix seed, 8g mint, 18g yam, 7g cardamom, 15g lily bulb, 35g papaya, 18g platycodon grandiflorus, 7g citron, 7g Ganoderma lucidum.

[0034] Preparation method: Same as in Example 1.

[0035] The following experimental examples illustrate the beneficial effects of the present invention.

[0036] Experimental Example 1: Taste Study of the Composition of the Invention

[0037] 1. Experimental materials

[0038] Sample 1:

[0039] Formula: 30g Polygonatum sibiricum, 10g red adzuki bean, 15g coix seed, 5g mint, 15g yam, 10g cardamom, 15g lily bulb, 30g papaya, 15g platycodon grandiflorus, 5g citron, 5g Ganoderma lucidum.

[0040] Preparation process:

[0041] 1. Peppermint, cardamom, lily, papaya, platycodon, bergamot, and ganoderma were subjected to water extraction with polysaccharide content and extract as indicators. The material-to-liquid ratio was 1:10 (w / w). The raw materials were soaked for 15 minutes and extracted for 30 minutes. After extraction three times, the mixture was filtered, and the extract content reached 13.9%.

[0042] 2. The extract is concentrated under reduced pressure (60℃, 0.08 MPa) to a density of 1.08-1.10 (60℃), which facilitates drying into powder.

[0043] 3. The concentrate is spray-dried, with the feed temperature controlled at 50-60℃, the liquid density at 1.08-1.10 (60℃), the inlet air temperature at 185-195℃, and the outlet air temperature at 95-105℃, to obtain dried powder for later use.

[0044] 4. Place the raw material residue in an oven and heat it at 110℃ for 30 minutes, then heat it at 80℃ for 90 minutes. Crush the dried raw material residue and sieve it to 100 mesh for later use. The raw material residue obtained under these conditions has low moisture content and a suitable sensory taste.

[0045] 5. After drying the remaining ingredients in the formula, namely Polygonatum sibiricum, red adzuki bean, coix seed, and yam, at 110℃ for 2 hours, directly pulverize them to 100 mesh and set aside. The powder obtained under these conditions has a better taste and no fishy smell of raw medicinal materials.

[0046] 6. After mixing all the dried materials thoroughly, package them into portions to obtain the finished product.

[0047] Sample 2:

[0048] Weigh the raw materials according to the formula in Sample 1, and perform water extraction at a material-to-liquid ratio of 1:10 (w / w). The raw materials are soaked for 15 minutes and extracted for 30 minutes. After extraction three times, the mixture is filtered. The extract is concentrated under reduced pressure (temperature 60℃, vacuum degree 0.08Mpa) to a density of 1.08-1.10 (60℃), and then spray-dried (feed temperature 50-60℃, material-to-liquid density 1.08-1.10 (60℃), inlet air temperature 185-195℃, outlet air temperature 95-105℃) to obtain powder.

[0049] Sample 3:

[0050] Weigh the raw materials according to the formula in Sample 1, crush them directly, pass them through a 100-mesh sieve, and mix all the raw material powders to obtain the final product.

[0051] 2. Sensory evaluation of oral preparations

[0052] Ten participants were tested (five from Traditional Chinese Medicine and five from Food Science, all of whom had completed training according to GB / T16291.1). A double-blind method was used, and the participants directly consumed equal amounts (2g) of samples 1-3. The taste was scored according to the standards in Table 1, and the results are shown in Table 2.

[0053] Table 1. Taste Rating Criteria (out of 10)

[0054]

[0055] Table 2 Sensory evaluation results

[0056]

[0057] The results above demonstrate that sensory evaluation comparing samples prepared using the three processes reveals that directly extracting or pulverizing the prescription ingredients without separate processing and innovative techniques results in poor palatability, hindering the long-term effectiveness of traditional Chinese medicine and significantly diminishing the prescription's efficacy. In contrast, the lactation-promoting product obtained using the process of this invention exhibits excellent sensory qualities, is easily accepted by consumers, and its superior taste allows for long-term use, thus promoting certain therapeutic effects.

[0058] Experimental Example 2: Study on the Influence of Process Parameters on Taste

[0059] 1. Experimental materials

[0060] Sample 1:

[0061] Formula: 30g Polygonatum sibiricum, 10g red adzuki bean, 15g coix seed, 5g mint, 15g yam, 10g cardamom, 15g lily bulb, 30g papaya, 15g platycodon grandiflorus, 5g citron, 5g Ganoderma lucidum.

[0062] Preparation process:

[0063] 1. Peppermint, cardamom, lily, papaya, platycodon, bergamot, and ganoderma were extracted with water at a material-to-liquid ratio of 1:10 (w / w), using polysaccharide content and extract as indicators. The raw materials were soaked for 15 minutes and extracted for 30 minutes. After extraction three times, the mixture was filtered, and the extract content reached 13.9%.

[0064] 2. The extract is concentrated under reduced pressure (60℃, 0.08 MPa) to a density of 1.08-1.10 (60℃), which facilitates drying into powder.

[0065] 3. The concentrate is spray-dried, with the feed temperature controlled at 50-60℃, the liquid density at 1.08-1.10 (60℃), the inlet air temperature at 185-195℃, and the outlet air temperature at 95-105℃, to obtain dried powder for later use.

[0066] 4. Place the raw material residue in an oven and heat it at 110℃ for 30 minutes, then heat it at 80℃ for 90 minutes. Crush the dried raw material residue and sieve it to 100 mesh for later use. The raw material residue obtained under these conditions has low moisture content and a suitable sensory taste.

[0067] 5. After drying the remaining ingredients in the formula, namely Polygonatum sibiricum, red adzuki bean, coix seed, and yam, at 110℃ for 2 hours, directly pulverize them to 100 mesh and set aside. The powder obtained under these conditions has a better taste and no fishy smell of raw medicinal materials.

[0068] 6. After mixing all the dried materials thoroughly, package them into portions to obtain the finished product.

[0069] Sample 2:

[0070] Take all the raw materials according to the formula of Sample 1, and change step 2 to concentration under normal pressure according to the preparation process of Sample 1. Control the density of the concentrate at 1.08-1.10, and keep other operations unchanged to obtain Sample 2.

[0071] Sample 3:

[0072] Take all the raw materials according to the formula of Sample 1, and change step 3 according to the preparation process of Sample 1: control the feed temperature to room temperature of 25℃, the air inlet temperature to 170-185℃, and the air outlet temperature to 80-90℃, while keeping other operations unchanged, and thus obtain Sample 3.

[0073] Sample 4:

[0074] Take all the raw materials according to the formula of Sample 1, and change step 3 according to the preparation process of Sample 1: control the feed temperature to 60-80℃, the air inlet temperature to 150-160℃, and the air outlet temperature to 60-80℃, while keeping other operations unchanged, and thus obtain Sample 4.

[0075] Sample 5:

[0076] Take all the ingredients according to the formula of Sample 1, and follow the preparation process of Sample 1, except for step 4, while keeping other operations unchanged, to obtain Sample 5.

[0077] Sample 6:

[0078] Take all the raw materials according to the formula of Sample 1, and follow the preparation process of Sample 1, but change step 4 to: directly heat and dry at 110-120℃ for 90 minutes, crush the dried raw material residue, and sieve it to 100 mesh for later use. Keep other operations unchanged, and thus obtain Sample 6.

[0079] 2. Process observation under different process parameters and sensory evaluation of oral formulations

[0080] Ten participants were tested (five from Traditional Chinese Medicine and five from Food Science, all of whom had completed training according to GB / T 16291.1). A double-blind method was used, and the participants directly consumed equal amounts (2g) of samples 1 to 6. The taste was scored according to the standards in Table 1, and the results are shown in Table 3.

[0081] Table 3. Results of process observation and sensory evaluation under different process parameters.

[0082]

[0083]

[0084] By altering the process parameters in steps such as extract concentration, spray drying, and raw material residue powdering, the effects of each step on the process were observed and recorded. Sensory evaluations of the obtained samples were also conducted. Comprehensive comparisons revealed that changing the process conditions significantly altered the sensory properties and the powder yield after spray drying. Since sensory perception influences consumer acceptance of the final product, and powder yield is related to the economic costs of the production process, only under the process steps and parameters of this invention can a highly acceptable oral lactogenic preparation be obtained, thereby reducing the consumption costs for the target population.

Claims

1. A composition having a milk-enhancing effect, characterized in that: It is an oral preparation made from the following raw materials in parts by weight: 25-35 parts of Polygonatum sibiricum, 7-13 parts of red adzuki bean, 10-20 parts of coix seed, 2-8 parts of peppermint, 12-18 parts of yam, 3-7 parts of cardamom, 10-15 parts of lily bulb, 25-35 parts of papaya, 12-18 parts of platycodon grandiflorus, 2-7 parts of citronella, and 2-7 parts of Ganoderma lucidum; the preparation method of the oral preparation is as follows: 1) Take peppermint, cardamom, lily bulb, papaya, platycodon grandiflorus, citronella, and Ganoderma lucidum, add water to extract, concentrate the extract, dry to obtain dried powder A; dry and pulverize the raw material residue, sieve to obtain dried powder B; 2) Take Polygonatum sibiricum, red adzuki bean, coix seed, and yam, dry and pulverize, sieve to obtain dried powder C; 3) Take the raw material residue from step 1) Dry powder A and dry powder B are mixed with dry powder C from step 2) to obtain the product; the concentration in step 1) is vacuum concentration at a temperature of 60℃ and a vacuum degree of 0.08Mpa; the concentrated liquid obtained by vacuum concentration is spray dried at a feed temperature of 50-60℃, an air inlet temperature of 185-195℃, and an air outlet temperature of 95-105℃; the relative density of the concentrated liquid is 1.08-1.10; the raw material residue is first heated and dried at 110℃ for 30 minutes, and then heated and dried at 80℃ for 90 minutes; the sieving is done through a 100-mesh sieve; the drying temperature in step 2) is 110℃ for 2 hours, and the sieving is done through a 100-mesh sieve.

2. A composition having a milk-enhancing effect, characterized in that: It is an oral preparation made from the following raw materials in parts by weight: 30 parts Polygonatum sibiricum, 10 parts red adzuki bean, 15 parts coix seed, 5 parts peppermint, 15 parts yam, 10 parts cardamom, 15 parts lily bulb, 30 parts papaya, 15 parts platycodon grandiflorus, 5 parts citronella, and 5 parts Ganoderma lucidum. The preparation method of the oral preparation is as follows: 1) Take peppermint, cardamom, lily bulb, papaya, platycodon grandiflorus, citronella, and Ganoderma lucidum, add water to extract, concentrate the extract, and dry to obtain dried powder A; dry and pulverize the raw material residue, and sieve to obtain dried powder B; 2) Take Polygonatum sibiricum, red adzuki bean, coix seed, and yam, dry and pulverize, and sieve to obtain dried powder C; 3) Take dried powder A and dried powder B from step 1). Mix with the dried powder C from step 2) to obtain the product; the concentration in step 1) is vacuum concentration at a temperature of 60℃ and a vacuum degree of 0.08Mpa; the concentrated liquid obtained by vacuum concentration is spray dried, with a feed temperature of 50-60℃, an air inlet temperature of 185-195℃, and an air outlet temperature of 95-105℃; the relative density of the concentrated liquid is 1.08-1.10; the raw material residue is first heated and dried at 110℃ for 30 minutes, and then heated and dried at 80℃ for 90 minutes; the sieving is through a 100-mesh sieve; the drying temperature in step 2) is 110℃ for 2 hours, and the sieving is through a 100-mesh sieve.

3. The composition according to claim 1 or 2, characterized in that: Step 1) The extraction is a decoction extraction. Soak for 15 minutes before decoction, then decoct for 30 minutes. Decoction is performed 3 times. The amount of water added each time is 10 times that of the raw material, w / w.

4. Use of the composition according to any one of claims 1 to 3 in the preparation of a medicament having a milk-enhancing effect.

5. Use of the composition according to any one of claims 1 to 3 in the preparation of a health food product having a function of promoting lactation.

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