Liquid Adjustable Intraocular Lens with Asymmetric Chambers

Abstract

An adjustable intraocular lens (IOL) is formed by: a front half or a rear half molded into a chamber-shaped polymer bag having a mouth opening smaller than its maximum width, which is paired with the other half molded into a flexible bowl, the edge of the flexible bowl being larger than the rest of the other half. The resulting housing has a seam parallel to and not crossing or contacting the equator, such that the IOL is asymmetric between its front and rear parts. Circular depressions around the optical axis can be made in the front half and / or the rear half, such that the surrounding capsular bag is sealed on the edges of the depressions and the interior of the one or more depressions does not contact the capsular bag.

Description

[0001] Cross - reference to related applications

[0002] This application claims the benefit of U.S. Provisional Application No. 63 / 545,255, filed on October 23, 2023, which is hereby incorporated by reference in its entirety for all purposes. Technical field

[0003] The present disclosure relates to the technical field of intraocular lenses implanted in the body. More specifically, it relates to a liquid - adjustable intraocular lens that has an adjustable focal length by changing its shape, which is facilitated by a front half having a shape different from its rear half. One - half of the front lens or the rear lens is molded into a wide - mouthed pouch, where the mouth is smaller than the widest periphery, and the other half is molded into a flexible bowl, and the two halves are joined such that the seam is away from the widest periphery. Background art

[0004] Cataract extraction combined with intraocular lens (IOL) implantation remains one of the only effective cataract treatment methods currently and for some time to come. Although implanting a traditional monofocal intraocular lens after cataract surgery can achieve good distance vision, monofocal intraocular lenses do not have the ability to adjust the focal length. After the surgery, patients generally have hyperopia and need to rely on glasses to meet the requirements of different near - distance work.

[0005] Multifocal intraocular lenses adopt a unique optical design and can form two or more foci simultaneously in the eye. After the surgery, patients can adjust the pupil size and select different foci to meet the needs of hyperopia and myopia, which reduces the ratio of cataract patients wearing glasses after the surgery. However, when there are multiple foci, they can cause drawbacks such as halos and glare to patients.

[0006] In recent years, some scholars have attempted to design adjustable intraocular lenses by changing the filling amount of the optical fluid medium (such as silicone oil) in the capsular bag or by changing the type of the optical fluid medium.

[0007] There is a need in the art for improved intraocular lenses that can be adjusted, preferably by the patient's own ciliary eye muscles. Summary of the invention

[0008] It generally describes an intraocular lens that can be filled with liquid, having a flexible bag with a wide mouth molded in its front half or rear half, and the opening of the flexible bag with a wide mouth is slightly curved inward to form a mouth slightly smaller than the widest part of the bag. The widest part is sometimes called the equator. The bag is connected to the other half, which is molded more like a flexible bowl in the shape of gummy candy, and its widest part is at its opening. These two halves are connected together to form a watertight flexible housing, and its seam is neither on nor crosses its equator. The housing that can be filled through a self-sealing valve is considered "asymmetric" between its front (front) part and rear (rear) part.

[0009] Depressions can be molded on one or both of the front half and the rear half, such that when filled and inserted into the patient's capsular bag, the capsular bag forms a tight seal all the way around the edge of the depression. That is to say, the edge of the depression is continuous without spikes, pits or other features that may interfere with the seal. The depth of the depression is sufficient so that its highest part (which is usually at the center) does not touch the top of the capsular bag.

[0010] Haptic arms can extend from the equator, or from areas on both sides of the equator but not on the equator. Pairs of haptic arms located on both sides of the equator or the seam can be connected at their ends.

[0011] Some embodiments of the present invention relate to: a first half formed by a polymer bag with a mouth smaller than the equator of the bag; a second half formed by a flexible bowl with an edge; a seam connecting the mouth of the first half to the edge of the second half to form a housing that can be filled with liquid, and the optical axis passes through the first half and the second half; and a sealable valve in the housing.

[0012] The seam can be parallel to the equator. The distance between the seam and the equator can be between 1.0 mm and 1.5 mm.

[0013] A depression can be formed in the housing, having a continuous edge disposed around the optical axis, and the continuous edge is configured to seal the capsular bag during implantation. When the housing is filled with liquid, the highest point in the depression can be lower than the continuous edge, and the depression is configured to keep the capsular bag away from the wall material in the depression. A second depression can be formed in the housing, having a continuous edge disposed around the optical axis, and the continuous edge of the second depression is configured to seal the capsular bag during implantation. When the housing is filled with liquid, the highest point in the second depression can be lower than the continuous edge of the second depression, and the second depression is configured to keep the capsular bag away from the wall material in the second depression.

[0014] The haptic can be connected to the equator. A first set of haptic arms can project from an area on the housing that is not on the equator. A second set of haptic arms can project from an area on the hemisphere of the equator on the housing that is opposite the first set of haptic arms. The ends of the first haptic arms and the second haptic arms can be joined together. The first set of haptic arms can be connected to the first half at half the thickness of the first half; and the second set of haptic arms can be connected to the second half at half the thickness of the second half.

[0015] The sealable valve can include a ring and a self-sealing polymer body surrounded by the ring, the polymer body being softer than the ring. The hardness of the ring can be between 80 Shore A and 90 Shore A, and the hardness of the polymer body is between 20 Shore A and 40 Shore A. A parylene layer can be laid above the sealable valve. The liquid can fill the liquid-fillable housing.

[0016] Some embodiments relate to a method of manufacturing and testing an adjustable intraocular lens, the method including: providing a first half formed from a polymer bag having a mouth smaller than the equator of the bag; providing a second half formed from a flexible bowl having an edge; joining the mouth of the first half to the edge of the second half to form a liquid-fillable housing, the optical axis passing through the first half and the second half; and filling the housing with liquid through a sealable valve.

[0017] The joining can include: adding uncured polymer to the first half and the second half to form a seam, wherein the seam is parallel to the equator. During testing or other processes, a person can squeeze or pull the equator, such squeezing or pulling being capable of increasing the wall curvature of one of the halves around the optical axis to be greater than the wall curvature of the other half around the optical axis. The method can also include: joining the ends of the first haptic arms projecting from a point on the housing that is not on the equator, with the ends of the second haptic arms projecting from a point on the hemisphere of the equator on the housing that is opposite the first haptic arms. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a perspective view of an adjustable intraocular lens device according to one embodiment.

[0019] Figure 2A is a perspective view of an adjustable intraocular lens device having a recess according to one embodiment.

[0020] Figure 2B is Figure 2A an axial cross-sectional view of the intraocular lens device.

[0021] Figure 3 is a perspective view of an adjustable intraocular lens device having a seam above the equator when looking downward toward the front side according to one embodiment.

[0022] Figure 4 is a perspective view of an adjustable intraocular lens device with a haptic portion according to one embodiment.

[0023] Figure 5 is a perspective view of an adjustable intraocular lens device with a haptic portion and a recessed portion according to one embodiment.

[0024] Figure 6A is an exploded perspective view of two halves (anterior capsule and posterior capsule) of an intraocular lens device having haptic arms on both sides of the equator according to one embodiment.

[0025] Figure 6B is Figure 6A a perspective view of the two halves of the device connected.

[0026] Figure 7 is a flowchart showing a process according to one embodiment. Detailed Description

[0027] Describes a fillable liquid adjustable intraocular lens (IOL) having different anterior and posterior halves. One of the halves is cavity - type or chamber - type in that its opening or mouth is smaller than the widest part inside. The other half is more like an open - mouthed bag with the mouth of the open - mouthed bag at its widest point. When these two halves are welded or otherwise connected together, the seam between the two halves does not fall on the maximum circumference (also called the equator) of the resulting housing.

[0028] Thus, the anterior and posterior halves or capsules in the adjustable intraocular lens are asymmetric with respect to each other. This design avoids their seams at the equator, which is beneficial for reducing stress concentration or deformation of the entire capsule housing and obtaining good mechanical properties, which can improve the refractive effect of the intraocular lens.

[0029] One or more sealable valves or designated areas for needles to pass through are provided on the front surface of the IOL so that a doctor can fill the housing after implanting it into the patient's eye (usually implanted into the capsular bag).

[0030] "Bisecting" includes dividing into two parts, or other forms known in the art. These two parts are not necessarily equal parts.

[0031] The "periphery" of a three - dimensional object includes a circular, elliptical or other closed - shaped periphery around a central axis as visible from a cross - sectional view of the object, or other forms known in the art. It does not necessarily mean the maximum periphery of the object.

[0032] The "equator" of a three-dimensional object includes the maximum perimeter of the object, or other forms known in the art.

[0033] A "half part" or "hemisphere" of a device refers to a part of the device when the device is divided into two parts or consists of two parts, or other forms known in the art. The half part is not necessarily anywhere near the exact half of the object, but is a substantial part of the device.

[0034] The "optical axis" of a device is a transparent region designed to allow visible light to pass through, usually but not necessarily used to define the radial symmetry of the device around it, or other forms known in the art.

[0035] A "sealable valve" includes an area designated for a needle to pass through and can be automatically sealed or sealed in other ways when the needle is withdrawn according to its material thickness, elasticity, or other characteristics, or other forms known in the art.

[0036] Figure 1 is a perspective view of the adjustable intraocular lens device 100. It consists of a liquid-filled housing 102 made of a flexible polymer such as silicone and filled with liquid silicone as shown. The housing or capsule is circular around the optical axis 106 and has an equator 104 defined by the outer peripheral edge farthest from the optical axis.

[0037] The housing can be made of silicone, siloxane, fluorosilane, or hydrophilic or hydrophobic acrylate. In some cases, silicone is preferred.

[0038] The anterior capsule (shown at the top in the figure) and the posterior capsule (shown at the bottom in the figure) can be bonded together to form a near-ellipsoidal structure simulating the human lens. The solid glass lens is sometimes plano-convex. The capsule housing is considered asymmetric ellipsoidal. The radial (distance) line continuously increases from front to back and starts to decrease if going backward when reaching the maximum value, and the maximum value in the middle is at the equator. Since stress concentration or slight deformation is likely to occur at the equator, affecting the refractive effect, the seam between the anterior capsule and the posterior capsule should avoid the equator to prevent capsule deformation. Therefore, the desired refractive effect can be better guaranteed.

[0039] A seam 136 is formed between the anterior half part and the posterior half part. The seam 136 is parallel to the equator 104 at a constant distance 105. In some embodiments, a distance between 1.0 millimeter (mm) and 1.5 millimeters has been found to work well. Among them, the connection between the anterior capsule and the posterior capsule in the capsule forms a seam line 136, and the seam line 136 forms an integral ring. Therefore, the seam line bears relatively uniform force during implantation.

[0040] A sealable valve 108, sometimes also referred to as a sealing valve, is provided on the mostly visible front half of the device. This enables an eye doctor to perform filling or adjustment.

[0041] Figures 2A to 2B An adjustable intraocular lens device 200 is shown. Visible from Figure 2A are large features in the front portion of the housing 202: depressions, depression regions.

[0042] From Figure 2B the cross-section, it can be seen that there are two such depressions, a front depression 241 in the front half 264 and a rear depression 240 in the rear half 268. Both the front depression 241 and the rear depression 240 have continuous edges 243 and 242 surrounding them and the optical axis 206. The continuous edges avoid having local pits, sharp protrusions or other features, such that when the housing 202 is implanted into an object's body, the edges can seal the surrounding capsular bag.

[0043] One technical advantage of this seal is that it helps prevent proliferation of foreign tissue, in which cells grow and migrate along the housing from the outer region to the middle over time, where they may block vision around the optical axis.

[0044] As shown in the figure, the continuous edge 243 is higher than the highest point 245 within the depression 241. That is, any line from edge to edge does not touch any part of the depression within the edge. Similarly, the continuous edge 242 is higher (i.e., further away from the interior) than the highest point 244 within the depression 240. This configuration keeps the surrounding capsular bag tissue away from the wall 218 of the housing 202.

[0045] One technical advantage of keeping the wall away from the capsular bag is that it allows a surgical laser to precisely cut parts of the capsular bag without localizing the heat energy of the laser beam on the capsular bag and melting one side of the housing.

[0046] During manufacturing, the housing 202 is composed of two halves (a front half 264 and a rear half 268). These two halves are joined at a seam 236. The seam 236 travels all the way around the housing 202 but is neither located at the equator 204 nor crosses the equator 104. Further, a polymer 238 added for sealing and helping to reinforce the seam has now cured, and it is neither located at the equator 204 nor crosses the equator 104.

[0047] One technical advantage of avoiding the equator from the seam is that the thickness of the seam is usually thicker or more uneven than the rest of the housing, allowing the equator to more consistently carry and transfer the stress that causes the lenses to move relative to each other.

[0048] The wall 218 of the housing 202 surrounds the entire device. The outer peripheral edge of the wall is located on the outer side of the device, and the largest outer peripheral edge 214 is marked as the device equator 204. At the same time, the inner peripheral edge is located on the inner side of the wall 218 facing the optical filling liquid 234.

[0049] The optical filling medium may include silicone oil, silane, ophthalmic sterile heavy water (perfluorodecalin C10F18), and HEALON sodium hyaluronate and the like.

[0050] The optical filling medium 234 is injected through the sealable valve 208. The sealable valve 208 includes a hard polymer ring 232 sometimes called an annulus body disposed within the front half 264. The ring 232 surrounds the self-sealing polymer body 230, and the Shore hardness of the body 230 is less than that of the ring 232. For example, the hardness of the ring may be between 80A Shore and 90A Shore, and the hardness of the polymer body may be between 20A Shore and 40A Shore.

[0051] The valve body is preferably circular, and the ring is preferably an annulus. When injecting the optical fluid medium from the sealable valve 208, due to the lower hardness of the body than the surrounding ring, it is locally adapted for the injection needle to enter the capsule housing 202. Additionally, with a soft body, it is easier to achieve sealing after removing the injection needle to prevent leakage of the optical fluid medium. The ring may be made of hard silicone, and the valve body may be made of soft silicone.

[0052] The parylene layer may cover the outer surface of the sealable valve 208 and also partially overlap with the outer surface of the capsule 202. This overlap increases the contact area of the parylene layer with the sealable valve 208 for adhesion and helps avoid potential stress concentration at the interface between the sealable valve 208 and the capsule housing 202.

[0053] The Young's modulus and hardness of the parylene layer are significantly higher than those of the sealable valve 208, and the adhesion between the parylene layer and the sealable valve 208 is better, which is equivalent to making a reinforcing baffle layer outside the seal valve. Therefore, when the injection needle is withdrawn, the optical fluid medium (such as silicone oil) in the seal valve can generate an outward pressure on the seal valve, and this outward pressure can cause the seal valve to self-close under the protection of the rigid parylene layer, so that it can play a role in sealing and leakage prevention for a long time.

[0054] In the exemplary embodiment in the figure, two sealable valves 208 are symmetrically arranged on the central axis 206 of the capsule 202. One of the sealable valves can be used for injection, while the other sealable valve can play a role in mechanical compensation and balance, and it can also be used as a spare valve. Other numbers of sealable valves can be used.

[0055] When the housing is filled with liquid, radially pulling or pushing on the equator changes the curvature of wall 218. In some embodiments, this force changes the curvature of the wall in the front half around the optical axis to be greater than the curvature of the wall in the rear half around the optical axis. This allows for an asymmetric curvature of the front and rear optical regions.

[0056] The wall thickness in the front half can be thinner than the wall thickness in the rear half, or vice versa, to facilitate the preferred bending and curvature.

[0057] Figure 3 is a perspective view of an adjustable intraocular lens device 300 having a seam above the equator. That is, the front half is molded as a flexible bowl with an edge, and the front half is molded as a polymer bag with a mouth that is smaller than the equator 304 of the bag.

[0058] These two halves are joined at the mouth of the first half and the edge of the second half to form a liquid-fillable housing 302, and the optical path 306 passes through both the front half and the rear half. As shown in the figure, the result is a housing that is rounder on the front hemisphere than on the rear hemisphere.

[0059] The front hemisphere is integrated with a sealable valve 308 and a recess 341 that is symmetric about the optical axis 306.

[0060] Figure 4 and Figure 5 respectively show adjustable intraocular lens devices 400 and 500 having haptics.

[0061] In Figure 4 the haptic 470 projects outward from point 471. Point 471 is located on the equator 404 and is clear of the thickened polymer 438 around the seam.

[0062] In some embodiments, the front half lacks a recess, but the rear half includes a groove or other recess. The bottom of the recess can be configured as an optical lens. A converging lens or a diverging lens can be employed.

[0063] In Figure 5 the haptic 570 projects outward from point 571. Point 571 is located on the equator 504 and does not contact or cross the thickened polymer 538 around the seam. The figure also shows a recess 541 in the front half. The bottom of the recess can be configured as a converging or diverging optical lens.

[0064] Figures 6A to 6Bis a perspective view of device 600 having haptics 670 and haptics 672, where haptics 770 and haptics 772 originate from the front half 664 and the rear half 668 respectively. Like the haptics in other eye devices, the haptics support the device associated with the action of the ciliary muscle in the lens capsule of the object, adjusting the shape of the capsule. The haptics can also be directly sutured into the eye wall where the ciliary body is located and can be used without a capsular bag or when the capsular bag is damaged. The haptics can be made of polyvinylidene fluoride (PVDF), polymethylmethacrylate (PMMA), polyimide, acrylate, or other elastic biocompatible materials.

[0065] Figure 6A Shows the front half before connection, where the front part 664 has a maximum-width perimeter, i.e., the equator 604. The mouth 680 of the bag in the front half 664 has a diameter smaller than the equator 604. At point 671 on the front part 664, the anterior haptic connecting arm is connected to its outer surface. The point is approximately between the seam and the pole of the hemispherical half 664, i.e., at half the thickness of the front half 664. The second connecting arm in the same set of haptic arms is provided on the opposite side of the same hemisphere.

[0066] Similarly, on the rear half 668, the anterior haptic connecting arm is connected to the outer surface of the rear half at point 674. The point 674 is approximately between the seam and the pole of the hemispherical half 668, i.e., at half the thickness of the rear half 668. The second connecting arm in the second set of haptic arms on the rear half 668 is provided on the opposite side of the same hemisphere.

[0067] At this time, the ends 676 of the haptics 670 and 672 are free. When the two hemispheres, the front half 664 and the rear half 668, are connected together, the haptics can remain free. Alternatively, each haptic can be paired with its corresponding arm on the opposite hemisphere.

[0068] Figure 6A Shows that the edge 682 of the flexible bowl of the rear half 668 is wider than any other part of the rear half 668. To connect these two halves together, the edge 682 of the bowl-shaped rear hemisphere 668 winds around and seals with the mouth 680 of the front hemisphere 664.

[0069] Figure 6B Shows the front half 664 and the rear half 668 connected together at the seam region 638. In this exemplary embodiment, the ends of the haptics are angled and connected together to form a Y-shaped structure with a connected end 678. They can be bonded with an adhesive such as silicone.

[0070] One technical advantage of this configuration where the front connecting arm is connected to the rear connecting arm at its end is that these arms avoid the seam 638 between the halves and the equator 604. Through mechanical simulation analysis and experiments, it has been demonstrated that an optimal force position for the connection location of the haptic portion can be found. The split Y design can facilitate the force balance of the capsule during accommodation. It can also achieve controllable deformation, thereby improving the accuracy and effectiveness of accommodation.

[0071] Figure 7 is a flowchart showing a process according to one embodiment. In operation 701, a first half is provided, which is formed from a polymer bag having a mouth that is smaller than the equator of the bag. In operation 702, a second half is provided, which is formed from a flexible bowl having an edge. In operation 703, the mouth of the first half is connected to the edge of the second half to form a liquid-fillable housing, and the optical axis passes through the first half and the second half. In operation 704, the end of a first haptic arm protruding from a point on the housing that is not on the equator is connected to the end of a second haptic arm protruding from a point on the hemisphere of the equator on the housing that is opposite the first haptic arm. In operation 705, the housing is filled with liquid through a sealable valve.

[0072] Although what has been described above are considered to be the best mode and / or other examples, it should be understood that various modifications can be made therein, the subject matter disclosed herein can be implemented in various forms and examples, and its teachings can be applied in many applications, only some of which are described herein. The following claims are intended to claim any and all applications, modifications, and variations that fall within the true scope of this teaching.

[0073] Unless otherwise stated, all measurements, values, ratings, positions, amplitudes, dimensions, and other specifications stated in this specification, including those in the appended claims, are approximate and not exact. They are intended to have a reasonable range consistent with the functions they relate to and the conventions in the field to which they belong. For temperature or other engineering units, "about" includes measurements or settings within ±1%, ±2%, ±5%, ±10% or other tolerance ranges for the specified engineering unit as known in the art.

[0074] The scope of protection is limited only by the claims appended hereto at this time. This scope is intended and should be construed to cover a scope consistent with the ordinary meaning of the language used in the claims when interpreted in accordance with this specification and the subsequent prosecution history, and to cover all structural and functional equivalents.

[0075] Unless otherwise stated previously, all that is stated or illustrated is not intended and should not be construed to cause any component, step, feature, object, benefit, advantage, or equivalent to be dedicated to the public, whether or not it is recited in the claims.

[0076] It should be understood that the terms and expressions used herein have the same ordinary meaning as is given to such terms and expressions by their respective fields of inquiry and study, except where a specific meaning is otherwise proposed herein. Relative terms such as first and second may be used solely to distinguish one entity or action from another entity or action, and do not necessarily require or imply any actual such relationship or order between such entities or actions. The terms "comprising," "including," or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element preceded by "a" or "an" does not exclude the presence of additional identical elements in the process, method, article, or apparatus that includes the element.

[0077] The abstract is provided to allow the reader to quickly ascertain the nature of the technical disclosure. It should be understood that it is not to be used to interpret or limit the scope or meaning of the claims. Additionally, in the foregoing detailed description, it can be seen that for purposes of streamlining the present disclosure, various features are grouped together in various embodiments. The method of the disclosure should not be construed to reflect an intention that the claimed embodiments require more features than are expressly recited in each claim. On the contrary, as reflected in the appended claims, the inventive subject matter lies in less than all the features of a single disclosed embodiment. Accordingly, the appended claims are hereby incorporated into the detailed description, where each claim stands on its own as a separate claimed embodiment.

Claims

1. An adjustable intraocular lens device, comprising: A first half formed from a polymer bag having a mouth that is smaller than the equator of the bag; A second half formed from a flexible bowl having an edge; A seam that joins the mouth of the first half to the edge of the second half to form a liquid-fillable housing, with the optical axis passing through the first half and the second half; A sealable valve within the housing; Haptic arms protruding from the first half; And Haptic arms protruding from the second half, Wherein the haptic arms are joined at their ends remote from the housing and the equator.

2. The device according to claim 1, wherein The seam is parallel to the equator.

3. The apparatus according to claim 2, wherein The distance between the seam and the equator is between 1.0 mm and 1.5 mm.

4. The device according to claim 1, further comprising: A recess formed in the housing, the recess having a continuous edge disposed around the optical axis, The continuous edge configured to seal the capsular bag during implantation.

5. The device according to claim 4, wherein When the housing is filled with liquid, the highest point within the recess is below the continuous edge, The recess configured to keep the capsular bag away from the wall material of the housing within the recess.

6. The device according to claim 4, further comprising: A second recess formed in the housing, the second recess having a continuous edge disposed around the optical axis, The continuous edge of the second recess configured to seal the capsular bag during implantation.

7. The apparatus according to claim 6, wherein When the housing is filled with liquid, the highest point within the second recess is below the continuous edge of the second recess, The second recess configured to keep the capsular bag away from the wall material of the housing within the second recess.

8. The device according to claim 1, further comprising a haptic portion connected to the equator.

9. The device according to claim 1, wherein The haptic arms protruding from the first half do not protrude from the equator.

10. The device according to claim 9, wherein, The haptic arms are located on both sides of the equator.

11. The device according to claim 1, wherein, The angle between the joined ends of the haptic arms and the haptic arms forms a Y-shaped structure.

12. The device according to claim 1, wherein, The haptic arms protruding from the first half are connected to the first half at half the thickness of the first half; and The haptic arms protruding from the second half are connected to the second half at half the thickness of the second half.

13. The device according to claim 1, wherein The sealable valve comprises: A ring; and A self-sealing polymer body surrounded by the ring, the polymer body being softer than the ring.

14. The apparatus according to claim 13, wherein, The hardness of the ring is between 80 Shore A and 90 Shore A, and the hardness of the polymer body is between 20 Shore A and 40 Shore A.

15. The device according to claim 1, further comprising: A parylene layer above the outer surface of the sealable valve.

16. The device according to claim 1, further comprising: A liquid filling the liquid-fillable housing.

17. A method of manufacturing and testing an adjustable intraocular lens device according to any one of claims 1-16, the method comprising: Providing a first half formed from a polymer bag having a mouth that is smaller than the equator of the bag; Provide a second half, the second half being formed by a flexible bowl having an edge; Connect the mouth of the first half to the edge of the second half to form a liquid-fillable housing, with the optical axis passing through the first half and the second half; Pair the ends of a first tactile arm protruding from the first half with the ends of a second tactile arm protruding from the second half, wherein the connected ends are remote from the housing and the equator; And Fill the housing with liquid through a sealable valve.

18. The method according to claim 17, wherein, The connection includes adding uncured polymer to the first half and the second half to form a seam, wherein the seam is parallel to the equator.

19. The method according to claim 17, further comprising: Squeezing the equator to increase the wall curvature of one of the halves around the optical axis to be greater than the wall curvature of the other half around the optical axis.

20. The method according to claim 17, wherein The tactile arm protruding from the first half does not protrude from the equator.

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