A sampling and detection device for extracting liquid and a detection method for pharmaceutical liquid

Abstract

The present invention belongs to the technical field of extract sampling and detection, and specifically relates to a sampling and detection device for extracts and a method for detecting pharmaceutical liquids, including a support frame and a detection mechanism, wherein the detection mechanism is fixedly arranged on the support frame, and includes an infrared spectrometer and a liquid chromatograph; the sampling mechanism also includes a lifting component, a rotating component and a sampling component; the transmission mechanism includes a driving component, an adjusting component and a transmission plate, which are used to drive the sampling mechanism to move and transmit; the control device ensures the efficiency and accuracy of the sampling and detection process by accurately coordinating the work of each component. The present invention can realize accurate extraction of liquid medicine through the transmission mechanism and the sampling mechanism, and the sampling time can be set through the control device, and samples with different reaction times or different depths can be extracted. The detection mechanism detects the composition of the liquid medicine, and the detected data can be analyzed, and the data of multiple detection results can be compared and recorded.

Description

Technical Field

[0001] The invention belongs to the technical field of extract sampling and detection, and in particular relates to an extract sampling and detection device and a method for detecting pharmaceutical liquid. Background Art

[0002] An extract is a solution used to extract a substance. Common plant protein extracts generally contain components that lyse cells and inhibit proteases, as well as a certain pH value. Plant and animal extracts are often used in biopharmaceuticals. Drug extracts usually refer to liquids containing active ingredients obtained through the extraction process from raw materials such as plants, animals or minerals. After the extraction is completed, the extract needs to be sampled and tested to analyze the drug components in the extract. It can be used to prepare drugs, food supplements or other health products.

[0003] Testing is an activity that is performed to address a specific problem or goal, using specialized testing equipment, tools, or techniques. Testing can be preventive maintenance performed regularly, or it can be troubleshooting or troubleshooting after a specific event. The goal is to find possible defects or problems through detailed testing, analysis, and evaluation of equipment or products, and to take appropriate solutions.

[0004] In the process of sampling the extract, the existing extract sampling and detection device has different extract compositions, which leads to inconsistent fusion degrees of the extract at different times. Since the existing sampling method mainly uses manual multiple sampling during sampling, the sampling time cannot be controlled, resulting in deviations in the test results. When sampling at the same time, generally only one sample can be collected at a time, which cannot reflect the accurate situation of the extract. In order to determine the degree of fusion of the extract at different times, it is necessary to sample and test the liquid in the extract multiple times. When multiple sampling at different depths or different positions is required, it is necessary to repeat it multiple times, which is complicated to operate, time-consuming and labor-intensive, and has low sampling efficiency, affecting the progress of the test. Summary of the invention

[0005] The purpose of the present invention is to provide a sampling and detection device for extracts and a method for detecting pharmaceutical liquids, which can effectively and accurately extract extracts, and can be set according to time to extract different depths in different time periods. After extraction, the sample is driven by a transmission mechanism to be transmitted to a detection mechanism, and the components of the extract can be detected. At the same time, the detected data can be recorded and analyzed by a data processing device, and the extracts at different times can be compared.

[0006] The technical solution adopted by the present invention is as follows:

[0007] A sampling and detection device for extracting liquid, comprising a support frame and a detection mechanism, wherein the detection mechanism is fixedly connected to the support frame, and the detection mechanism comprises an infrared spectrometer and a liquid chromatograph fixedly arranged on the support frame;

[0008] It also includes a sampling mechanism, which includes a sampling component, and the sampling component is fixedly arranged at the output end of the lifting component;

[0009] A transmission mechanism, the transmission mechanism comprising a transmission plate slidably connected to the support frame, the sampling mechanism being fixedly connected to the transmission plate via an adjustment component;

[0010] A control device, the control device is fixedly mounted on the support frame and is electrically connected to the detection mechanism, the sampling mechanism and the transmission mechanism respectively;

[0011] Among them, the control device can set the operating time of the sampling mechanism to perform sampling at different times and depths. After the sampling is completed, the sample can be driven into the detection mechanism through the transmission mechanism, and the infrared spectrometer and the liquid chromatograph can be used for detection and analysis.

[0012] Furthermore, the infrared spectrometer comprises a shell, a detection area is provided on the shell, and a light source, a control system and a detection system are provided inside the shell.

[0013] Furthermore, the liquid chromatograph comprises an equipment housing, a sample injection area is arranged on the equipment housing, and a chromatographic column and a detector are arranged inside the equipment housing.

[0014] Furthermore, the support frame is provided with sliding grooves on both sides, and the sliding grooves are provided with driving components, the driving components include a driving motor fixedly arranged in the sliding grooves and a driving guide rod, the output end of the driving motor is fixedly connected to a driving screw, and the other end of the driving screw is rotatably connected to the sliding groove;

[0015] There are two transmission plates, and a driving hole and a guide hole are respectively opened at the bottom of the two transmission plates. The driving hole is threadedly connected to the driving screw rod, and the guide hole is slidably connected to the driving guide rod.

[0016] Further, the adjustment assembly includes an adjustment screw rotatably arranged on the two transmission plates, and an adjustment guide rod fixedly arranged between the transmission plates, the adjustment screw is fixedly arranged at the output end of the adjustment motor, and the adjustment motor is fixedly arranged on the outside of any one of the transmission plates;

[0017] Wherein, the adjustment component also includes an adjustment plate, and the adjustment plate is provided with an adjustment hole and a sliding hole, the adjustment hole is threadedly connected to the adjustment screw, and the sliding hole is slidably connected to the adjustment guide rod.

[0018] Furthermore, the lifting assembly also includes a lifting motor fixedly mounted on the adjustment plate, and a lifting guide rod fixedly mounted in the adjustment plate, a lifting screw is fixedly mounted on the output end of the lifting motor, and the lifting screw is rotatably connected to the adjustment plate;

[0019] The lifting assembly further comprises a lifting plate rotatably arranged on the lifting screw, a rotating hole and a connecting hole are provided on the lifting plate, the rotating hole is threadedly connected to the lifting screw, and the connecting hole is slidably connected to the lifting guide rod.

[0020] Furthermore, the sampling mechanism also includes a rotating component fixedly arranged at the bottom of the lifting plate, the rotating component includes a rotating motor fixedly arranged at the bottom of the lifting plate, the output end of the rotating motor is fixedly connected to a rotating plate, a plurality of mounting holes are opened on the rotating plate along the center array of the rotating plate, and the sampling component is fixedly arranged in the mounting hole.

[0021] Furthermore, the sampling assembly includes an electric push rod fixed in the mounting hole, the output end of the electric push rod is fixedly connected to a sampler via a support plate, the sampler includes a sampling tube fixed at the bottom of the support plate, and the sampling tube is slidably provided with an extractor.

[0022] Furthermore, the control device includes a data processor, which is electrically connected to the sampling component, the lifting motor, the adjustment motor and the driving motor respectively. The operation time is set by the data processor, thereby controlling the movement of the above-mentioned devices.

[0023] Furthermore, a method for detecting a pharmaceutical liquid is provided, which is applied to the above-mentioned sampling and detection device for extracting liquid.

[0024] Step 1: setting the sampling and detection time by the control device so that the two groups of driving components respectively arranged in the sliding slot work simultaneously;

[0025] Step 2: Start the driving assembly and drive the transmission plate slidingly arranged in the sliding groove at the same time, and drive the regulating assembly arranged above it and the sampling mechanism located at the output end of the regulating assembly to move to the top of the extraction liquid through the transmission plate;

[0026] Step 3: The lifting component drives the rotating component, and the sampling component at the output end of the rotating component is lifted and moved, so that the sampling component moves into the extraction liquid for sampling, and at the same time, the rotating component is controlled to drive the sampling component to rotate, and sampling can be performed at different times according to time settings;

[0027] Step 4: The lifting component, the adjusting component and the driving component work in sequence to drive the sample in the sampling component to move to the top of the detection mechanism, and the sampling component is controlled to sequentially add the sample to the infrared spectrometer and the liquid chromatograph for detection.

[0028] The technical effects achieved by the present invention are:

[0029] The present invention discloses a sampling and testing device for extracting liquid, which can accurately extract the liquid medicine through the cooperation of the transmission mechanism and the sampling mechanism. The sampling mechanism can be quickly and accurately moved between different positions for sampling, thereby improving the flexibility and efficiency of the device. At the same time, the working efficiency of sampling and sample transportation can be significantly improved. The transmission mechanism and the sampling mechanism can also reduce the workload of the operator, reduce human errors, and ensure the consistency and reliability of the detection process. By accurately controlling the position of the sampling point, it can be ensured that each sampling can efficiently and accurately obtain a representative sample, thereby improving the reliability and reproducibility of the entire analysis and detection process.

[0030] The present invention provides a sampling and detection device for extracting liquid, which can detect the liquid medicine through the detection mechanism, facilitates the identification and quantitative analysis of the chemical components in the sample, and ensures the safe use of the pharmaceutical liquid medicine. At the same time, the transmission mechanism drives the sampling mechanism to transport the sample to the detection mechanism for detection, which can enhance the accuracy and repeatability, and ensure the accuracy and consistency of the sample detection. The operating efficiency and accuracy of the detection device are improved, and the adaptability and safety are also enhanced.

[0031] The present invention provides a sampling and detection device for extracting liquid, which can coordinate and control various actions of the sampling and detection device through a control device. By being electrically connected with a detection mechanism, a sampling mechanism and a transmission mechanism, the efficiency of the entire process from sampling to detection is improved, and at the same time, the sample processing speed and data quality can be significantly improved, human errors can be reduced, and overall efficiency and safety can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0033] Figure 2 It is an exploded schematic diagram of the overall structure of the present invention;

[0034] Figure 3It is a schematic diagram of the structure of the sampling mechanism and the transmission mechanism of the present invention;

[0035] Figure 4 It is a schematic diagram of the structure of the sampling mechanism of the present invention;

[0036] Figure 5 It is a partial structural cross-sectional view of the present invention;

[0037] Figure 6 It is a schematic diagram of the structure of the rotating assembly and the sampling assembly of the invention;

[0038] Figure 7 is a cross-sectional view of a rotating assembly and a sampling assembly of the present invention;

[0039] Figure 8 It is a partial cross-sectional view of the detection mechanism and the control device of the present invention;

[0040] Fig. 9 It is a schematic diagram of the transmission mechanism structure of the present invention;

[0041] Fig.10 It is a partial cross-sectional view of the detection mechanism of the present invention.

[0042] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0043] 10. Support frame; 11. Sliding slot;

[0044] 20. Detection mechanism; 21. Infrared spectrometer; 211. Shell; 212. Detection area; 22. Liquid chromatograph; 221. Equipment shell; 222. Sample injection area;

[0045] 30. Sampling mechanism; 31. Sampling assembly; 311. Electric push rod; 312. Support plate; 313. Sampler; 32. Lifting assembly; 321. Lifting motor; 322. Lifting guide rod; 323. Lifting screw; 324. Lifting plate; 33. Rotating assembly; 331. Rotating motor; 332. Rotating plate; 333. Mounting hole;

[0046] 40. Transmission mechanism; 41. Transmission plate; 411. Drive hole; 412. Guide hole; 42. Adjustment assembly; 421. Adjustment screw; 422. Adjustment guide rod; 423. Adjustment motor; 424. Adjustment plate; 425. Adjustment hole; 426. Sliding hole; 43. Drive assembly; 431. Drive motor; 432. Drive screw; 433. Drive guide rod;

[0047] 50. Control device; 51. Data processor. DETAILED DESCRIPTION

[0048] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is specifically described below in conjunction with embodiments. It should be understood that the following text is only used to describe one or several specific embodiments of the present invention, and does not strictly limit the scope of protection of the specific claims of the present invention.

[0049] like Figure 1-Figure 10 As shown, a sampling and detection device for extracting liquid includes a support frame 10 and a detection mechanism 20. The support frame 10 is fixedly connected with the detection mechanism 20. The detection mechanism 20 includes an infrared spectrometer 21 and a liquid chromatograph 22 fixedly arranged on the support frame 10.

[0050] It also includes a sampling mechanism 30, which includes a sampling assembly 31, and the sampling assembly 31 is fixedly arranged at the output end of the lifting assembly 32;

[0051] The transmission mechanism 40 includes a transmission plate 41 slidably connected to the support frame 10, and the sampling mechanism 30 is fixedly connected to the transmission plate 41 through an adjustment component 42;

[0052] A control device 50, which is fixed on the support frame 10 and is electrically connected to the detection mechanism 20, the sampling mechanism 30 and the transmission mechanism 40 respectively;

[0053] Among them, the operating time of the sampling mechanism 30 can be set by the control device 50, and sampling can be performed at different times and different depths. After the sampling is completed, the sample can be driven into the detection mechanism 20 through the transmission mechanism 40, and detection and analysis can be carried out through the infrared spectrometer 21 and the liquid chromatograph 22.

[0054] It should be noted that the detection mechanism 20 also includes a display screen (not shown in the figure), which is electrically connected to the infrared spectrometer 21 and the liquid chromatograph 22, respectively. The infrared spectrometer 21 and the liquid chromatograph 22 have their own data processing systems, which can compare and analyze the results of multiple tests, and then send them to the display screen for display and recording, so that the experimenter can observe and control the data more intuitively. Among them, the working principle of the data processor 51 is mainly based on control theory and microcontroller technology. It is responsible for receiving the time signal set by the control device 50, processing these signals through the data processor 51 and calculating the control amount according to the set control algorithm, and finally realizing the precise control of the detection mechanism 20, the sampling mechanism 30 and the transmission mechanism 40.

[0055] In this embodiment, the support frame 10 is used to fix and support the various components of the device, which can ensure that all components are kept in the correct position for accurate sampling and detection. The detection mechanism 20 is used to detect the liquid medicine, which is convenient for identifying and quantitatively analyzing the chemical components in the sample, and ensuring the safe use of the pharmaceutical liquid medicine. Among them, the detection mechanism 20 is composed of an infrared spectrometer 21 and a liquid chromatograph 22. The infrared spectrometer 21 obtains information about the sample by measuring the infrared radiation absorbed, emitted, reflected or transmitted by the sample, and can provide information about the structure and composition of the sample. The liquid chromatograph 22 separates the sample into various components through high-pressure liquid, and performs quantitative analysis through a detector to obtain information about the composition of the sample. The sampling mechanism 30 is used to quantitatively extract the liquid medicine to ensure quantitative and stable detection. Among them, a sampling component 31 is included for absorbing the liquid medicine, which is convenient for temporary storage of samples so that the samples can be transported to the detection mechanism 20. By arranging the lifting assembly 32 above the sampling assembly 31, the sampling assembly 31 can be effectively driven in the vertical direction, so that it can sample from different depths or positions as needed, and can adapt to sample containers of different sizes and shapes, and can perform sampling at multiple levels. The transmission mechanism 40 is used to ensure that the sample after sampling can be accurately transmitted to the detection mechanism 20. It includes a transmission plate 41 slidably arranged on the support frame 10, and the transmission plate 41 can provide a stable platform for sample transmission to ensure stable use during sampling and transmission. The transmission plate 41 can slide on the support frame 10 to adapt to sampling points at different positions and the entrance of the detection mechanism 20. By fixing the adjustment assembly 42 on the transmission plate 41, the sampling mechanism 30 and the transmission plate 41 can be fixedly connected, and the position of the sampling mechanism 30 can be accurately adjusted to ensure the accuracy and repeatability of sampling. The control device 50 can coordinate and control all actions. By being electrically connected to the detection mechanism 20, the sampling mechanism 30 and the transmission mechanism 40, the efficiency of the entire process from sampling to detection is improved. At the same time, the sample processing speed and data quality can be significantly improved, human errors can be reduced, and overall efficiency and safety can be improved. Specifically, the control device 50 can send instructions to control the time, position and depth of sampling, and can start and stop the movement of the sampling mechanism 30 and the transmission mechanism 40. The sampling component 31 is adjusted to the specified position by controlling the lifting component 32, and then the sampling component 31 collects the required sample for transmission. After the sampling is completed, the lifting component 32 can lift the sampling component 31 to an appropriate position so that the sample can be transferred to the detection mechanism 20, and the sample may also be automatically transmitted to the detection mechanism 20 through the transmission mechanism 40. After the sample is sent to the detection mechanism 20, it is analyzed by the infrared spectrometer 21 and the liquid chromatograph 22 successively or simultaneously, and the detection data is transmitted to the display, which can be compared, analyzed and displayed through the display.

[0056] like Figure 2 , Figure 8 , Fig.10 As shown, the infrared spectrometer 21 includes a housing 211, which is used to carry samples for detection and protect internal components. By providing a detection area 212 on the housing 211, the sampled liquid can be effectively placed. Among them, by providing a light source in the housing 211, it is ensured that the light can be smoothly irradiated onto the sample. The light source can emit light in the range of infrared to visible light, and the light will be absorbed to varying degrees when passing through the sample. Among them, through the control system provided inside the housing 211, it is possible to ensure that the various components work together to obtain accurate spectral data. At the same time, it controls and manages the intensity of the light source, the collection of the spectrum, and data processing. Among them, the detection system is responsible for capturing the spectral information after passing through the sample, and can convert the optical signal into an electrical signal, and can transmit the detection results and analysis results to the display screen for subsequent data processing and analysis.

[0057] like Figure 2 , Figure 8 , Fig.10 As shown, the liquid chromatograph 22 includes an equipment housing 221, which can protect the internal precision components, ensure that the instrument operates in a safer environment, and prevent dust and pollutants from affecting the experimental results. By setting an injection area 222 on the equipment housing 221, it is ensured that a small amount of sample can be accurately and repeatedly introduced into the chromatographic column, and an efficient and accurate injection process can be provided. A chromatographic column is also provided in the equipment housing 221, wherein the chromatographic column comprises a stationary phase and a mobile phase. The stationary phase is usually chemically modified silica gel particles, and the mobile phase is a liquid solvent. The distribution coefficients of the various components in the sample in these phases are different, causing them to move at different rates when passing through the chromatographic column, thereby achieving separation. Among them, a detector is also provided at the bottom of the chromatographic column for measuring and recording the separated components eluted from the chromatographic column. At the same time, it is electrically connected to the display to transmit the measured results to the display for comparative display.

[0058] like Figure 3 , Figure 5 , Fig. 9As shown, by providing the sliding grooves 11 on both sides of the support frame 10, it can be used in conjunction with the transmission plate 41, so that the transmission plate 41 can slide accurately on the support frame 10, thereby adapting to different sampling and detection requirements. At the same time, providing the sliding grooves 11 on both sides helps to balance the movement of the transmission plate 41 and avoid failures caused by unbalanced force caused by unilateral drive. By arranging the driving assembly 43 in the sliding groove 11, the transmission plate 41 can be effectively driven to move. Among them, the driving motor 431, as the core power source of the driving assembly 43, can provide the necessary power to drive the entire transmission mechanism 40. A driving screw 432 is fixedly arranged at the output end of the driving motor 431. When the motor is running, its power is transmitted to the driving screw 432 through the output shaft. Among them, by using the driving screw 432 in conjunction with the driving hole 411 provided at the bottom of the transmission plate 41, the rotation of the driving screw 432 will be converted into a linear motion of the transmission plate 41 along the screw axis direction. The driving assembly 43 further includes a driving guide rod 433 fixed in the sliding groove 11, and the driving guide rod 433 provides a stable path for the movement of the transmission plate 41. By slidingly connecting with the guide hole 412 at the bottom of the transmission plate 41, it can ensure that the transmission plate 41 remains stable during the sliding process, and prevents swinging or vibration caused by the movement of the driving screw 432.

[0059] like Figure 3 , Figure 4 , Figure 5 As shown, the adjustment component 42 includes an adjustment screw 421 that is rotatably arranged on two transmission plates 41, which is used to transmit power and then move the adjustment plate 424 arranged on the outside thereof. By fixing the adjustment screw 421 at the output end of the adjustment motor 423, it is ensured that it can be stably driven by the adjustment motor 423 to perform power transmission. Among them, the adjustment motor 423 is fixed on the outside of the transmission plate 41. When the adjustment motor 423 is started, its power output end drives the adjustment screw 421 to rotate, and the rotation speed and direction of the screw can be adjusted through the precise control of the motor, thereby driving the adjustment plate 424 to achieve fine position adjustment. By fixing the adjustment guide rod 422 between the transmission plates 41, it is used to support and guide the movement of the adjustment plate 424. Among them, the adjustment plate 424 is used to fix and support the lifting component 32, ensuring that the lifting component 32 drives the sampling component 31 to perform horizontal movement adjustment. By providing an adjustment hole 425 on the adjustment plate 424 that matches the thread of the adjustment screw 421, the adjustment plate 424 can be driven to move along the axis of the screw when the screw rotates. At the same time, a sliding hole 426 that matches the adjustment guide rod 422 is provided to ensure the stability and smoothness of the adjustment plate 424 during movement, thereby enhancing the stability during adjustment.

[0060] like Figure 2 , Figure 4 , Fig. 9As shown, the lifting motor 321 is the power source of the lifting assembly 32, which is used to provide driving force, and can provide precise position control and speed adjustment, thereby ensuring the accuracy and repeatability of the lifting action. By fixing the lifting motor 321 above the adjustment plate 424, stable support can be achieved to ensure the safety of the lifting motor 321 when in use. By setting the lifting screw 323 at the output end of the lifting motor 321, the power generated by the lifting motor 321 can be effectively transmitted. By fixing the lifting guide rod 322 between the adjustment plates 424, the stability during the lifting process can be increased to prevent shaking during the lifting process. Among them, the lifting plate 324 is used to carry the rotating assembly 33 and the sampling assembly 31, ensuring that the sampling assembly 31 can be lifted and lowered smoothly to complete the sampling smoothly. By opening a rotating hole threadedly connected to the lifting screw 323 on the lifting plate 324, the power generated by the lifting motor 321 can be effectively transmitted through the lifting screw 323 to drive the lifting plate 324 to move up and down. A connection hole is also provided for sliding connection with the lifting guide rod 322 to ensure smooth and accurate lifting movement, while preventing the lifting plate 324 from rotating or swinging during movement.

[0061] like Figure 5 , Figure 6 , Figure 7 As shown, by fixing the rotating assembly 33 at the bottom of the lifting plate 324, the sampling of the sampling assembly 31 can be provided with flexibility and accuracy, ensuring that the sampling assembly 31 can be driven to perform differentiated sampling at different times and different heights, and can efficiently collect samples, while improving the applicability of the sampling assembly 31. The rotating motor 331 fixedly arranged at the bottom of the lifting plate 324 can provide power to drive the rotating plate 332 located at its output end to rotate, and can accurately control the angle and speed of rotation, thereby ensuring the accuracy and repeatability of sampling. By fixing the rotating plate 332 at the output end of the rotating motor 331, the sampling assembly 31 can be carried to ensure the stability and safety of the sampling assembly 31 when in use. By providing a plurality of mounting holes 333 in an array on the rotating plate 332, the sampling assembly 31 is fixed to ensure the stability of the sampling assembly 31. At the same time, the setting of multiple sampling assemblies 31 can make the sampling mechanism 30 perform sampling diversity, while ensuring the accuracy of sample detection.

[0062] like Figure 4 , Figure 6 , Figure 7As shown, the electric push rod 311 is the main driving force for the sampling action of the sampling assembly 31. By fixing the electric push rod 311 in the mounting hole 333, the sampler 313 fixed at its output end can be driven to advance and recover. At the same time, by controlling the stroke distance and the advancement speed, it can adapt to different sampling depths and conditions. By setting the support plate 312 at the output end of the electric push rod 311, the sampler 313 can be effectively supported and fixed, and the shaking and deviation of the sampler 313 during the sampling process can be avoided. The sampler 313 can effectively extract and store samples from the liquid sampling point. Among them, the sampler 313 includes a sampling barrel fixed at the bottom of the support plate 312, and the sampling barrel is a container that can accommodate samples. By sliding an extractor on the sampling barrel, the sampling accuracy and efficiency can be improved. Through the precise control of the electric push rod 311, the sampler 313 can be inserted and withdrawn quickly and accurately, which can improve the efficiency and accuracy of sampling.

[0063] Preferably, the control device 50 serves as the brain of the entire sampling and detection device, and ensures the efficiency and accuracy of the sampling and detection process by accurately coordinating the work of each component. It includes a data processor 51, which is used to process and send signals and can issue corresponding control instructions. By being electrically connected to the sampling component 31, the lifting motor 321, the adjustment motor 423 and the drive motor 431, centralized control is conveniently achieved, making the operation of the equipment more coordinated and consistent, and improving the flexibility of operation and the response speed of the system. Among them, by setting the control device 50, control signals can be sent to each component through the data processor 51 to control the operating time and action sequence of each component, thereby realizing automated and programmed control.

[0064] A method for detecting a pharmaceutical liquid, applied to the above-mentioned sampling and detection device for an extract;

[0065] Step 1: The sampling and detection time are set by the control device 50 so that the two sets of driving components 43 respectively arranged in the sliding slot 11 work simultaneously;

[0066] Step 2: Start the driving assembly 43 and drive the transmission plate 41 slidingly disposed in the sliding groove 11 at the same time, and drive the regulating assembly 42 disposed above it and the sampling mechanism 30 located at the output end of the regulating assembly 42 to move to the top of the extraction liquid through the transmission plate 41;

[0067] Step 3: The lifting component 32 drives the rotating component 33, and the sampling component 31 at the output end of the rotating component 33 is lifted and moved, so that the sampling component 31 moves into the extraction liquid for sampling. At the same time, the sampling component 31 is driven to rotate by controlling the rotating component 33, and sampling can be performed at different times according to the time setting;

[0068] Step 4: The lifting component 32, the adjusting component 42 and the driving component 43 work in sequence to drive the sample in the sampling component 31 to move to the top of the detection mechanism 20, and the sampling component 31 is controlled to sequentially add the sample to the infrared spectrometer 21 and the liquid chromatograph 22 for detection.

[0069] The working principle of the present invention is as follows: when it is necessary to detect the pharmaceutical liquid, the pharmaceutical liquid is placed on the support frame 10, and the sampling and detection time is set by the control device 50, so that the data processor 51 processes the control signal and transmits it to each mechanism at the same time. Then, the two groups of driving components 43 respectively arranged in the sliding groove 11 are controlled to work simultaneously, so that the driving motor 431 drives the driving screw 432 located at its output end to rotate, and then drives the transmission plate 41 threadedly connected with the driving screw 432 to move. At the same time, it can drive the adjustment component 42 arranged above the transmission plate 41 and the sampling mechanism 30 arranged at the output end of the adjustment component 42 to move and transmit. Then, by starting the adjustment motor 423, the adjustment screw 421 drives the adjustment plate 424 to slide and adjust on the adjustment guide rod 422, and drives the sampling mechanism 30 to move above the liquid medicine, completing the horizontal transmission and horizontal adjustment of the sampling mechanism 30. Then, the lifting motor 321 in the lifting assembly 32 is controlled to drive the lifting screw 323 at its output end, and then the lifting plate 324 provided on the lifting screw 323 and the lifting guide rod 322 is driven to move up and down, and the sampling assembly 31 is driven to move into the liquid medicine. By controlling the rotating motor 331 provided at the bottom of the lifting plate 324, the rotating plate 332 at its output end and the sampling assembly 31 fixed in the mounting hole 333 can be driven to rotate, so that different sampling assemblies 31 can be rotated above the sampling point. The electric push rod 311 in the sampling assembly 31 can drive the support plate 312 and the sampler 313 at its output end to move. By controlling the extractor in the sampler 313 to slide in the sampling tube, the liquid medicine can be sampled. When the sampling is completed, the lifting assembly 32, the adjustment assembly 42 and the drive assembly 43 are operated in sequence, and the sample in the sampling assembly 31 is driven to move above the detection mechanism 20. Then, the liquid medicine is squeezed out by controlling the sampler 313, so that the liquid medicine drips into the detection area 212 on the infrared spectrometer 21. The light source, control system and detection system inside the housing 211 work simultaneously, which can be used to identify and quantify various components in the liquid medicine extract. By comparing the infrared spectrum of the standard sample, the content and proportion of each component in the sample can be determined. At the same time, the liquid medicine is dripped into the injection area 222 on the liquid chromatograph 22 by the sampling component 31. The concentration of the drug in the liquid medicine can be detected by the chromatographic column and detector in the device housing 221, and the absorption, distribution, metabolism and excretion process of the drug in the body can be analyzed. Then, the display in the detection mechanism 20 can effectively display and record the results detected by the infrared spectrometer 21 and the liquid chromatograph 22, and the analysis and comparison results of multiple detections by the detection mechanism 20 can be displayed, which is convenient for subsequent processing.

[0070] The above is only a preferred embodiment of the present invention. It should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the principles of the present invention, and these improvements and modifications should also be considered as the protection scope of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention shall be implemented according to the conventional means in the art unless otherwise specified and limited.

Claims

1. A sampling and detection device for extract, characterized in that: The invention comprises a support frame (10) and a detection mechanism (20), wherein the detection mechanism (20) is fixedly connected to the support frame (10), and the detection mechanism (20) comprises an infrared spectrometer (21) and a liquid chromatograph (22) fixedly arranged on the support frame (10); a sampling mechanism (30), wherein the sampling mechanism (30) comprises a sampling assembly (31), and the sampling assembly (31) is fixedly arranged at the output end of the lifting assembly (32); and a transmission mechanism (40), wherein the transmission mechanism (40) comprises a transmission plate (41) slidably connected to the support frame (10), and the transmission plate (41) is ... 2) the sampling mechanism (30) is fixedly connected; a control device (50), the control device (50) is fixedly arranged on the support frame (10), and is electrically connected to the detection mechanism (20), the sampling mechanism (30), and the transmission mechanism (40) respectively; the operation time of the sampling mechanism (30) can be set by the control device (50), and sampling at different times and depths can be performed; after the sampling is completed, the sample can be driven into the detection mechanism (20) by the transmission mechanism (40), and detection and analysis can be performed by the infrared spectrometer (21) and the liquid chromatograph (22); The support frame (10) is provided with sliding grooves (11) on both sides, and the sliding grooves (11) are provided with driving components (43), the driving components (43) comprising a driving motor (431) fixedly arranged in the sliding grooves (11) and a driving guide rod (433), the output end of the driving motor (431) is fixedly connected to a driving screw rod (432), and the other end of the driving screw rod (432) is rotatably connected to the sliding groove (11); there are two transmission plates (41), and the bottom of the two transmission plates (41) A driving hole (411) and a guide hole (412) are respectively provided, the driving hole (411) is threadedly connected to the driving screw (432), and the guide hole (412) is slidably connected to the driving guide rod (433); the adjusting assembly (42) comprises an adjusting screw (421) rotatably arranged on the two transmission plates (41), and an adjusting guide rod (422) fixedly arranged between the transmission plates (41), the adjusting screw (421) is fixedly arranged at the output end of the adjusting motor (423), and the adjusting motor (423) is fixedly arranged on the outside of any one of the transmission plates (41); the adjustment assembly (42) further includes an adjustment plate (424), the adjustment plate (424) is provided with an adjustment hole (425) and a sliding hole (426), the adjustment hole (425) is threadedly connected to the adjustment screw (421), and the sliding hole (426) is slidably connected to the adjustment guide rod (422); the lifting assembly (32) includes a lifting motor (321) fixedly arranged on the adjustment plate (424), and a lifting motor (321) fixedly arranged on the adjustment plate (424). A lifting guide rod (322) is disposed inside the adjustment plate (424); a lifting screw (323) is fixedly disposed at the output end of the lifting motor (321); the lifting screw (323) is rotatably connected to the adjustment plate (424); the lifting assembly (32) further comprises a lifting plate (324) rotatably disposed on the lifting screw (323); a rotating hole and a connecting hole are formed on the lifting plate (324); the rotating hole is threadedly connected to the lifting screw (323); and the connecting hole is slidably connected to the lifting guide rod (322).

2. The sampling and detection device for extract according to claim 1, characterized in that: The infrared spectrometer (21) comprises a housing (211), a detection area (212) is provided on the housing (211), and a light source, a control system and a detection system are provided inside the housing (211).

3. The sampling and detection device for extract according to claim 2, characterized in that: The liquid chromatograph (22) comprises a device housing (221), a sample injection area (222) is provided on the device housing (221), and a chromatographic column and a detector are provided inside the device housing (221).

4. The sampling and detection device for extract according to claim 3, characterized in that: The sampling mechanism (30) further comprises a rotating assembly (33) fixedly arranged at the bottom of the lifting plate (324), the rotating assembly (33) comprising a rotating motor (331) fixedly arranged at the bottom of the lifting plate (324), the output end of the rotating motor (331) being fixedly connected to a rotating plate (332), a plurality of mounting holes (333) being formed on the rotating plate (332) along a central array of the rotating plate (332), and the sampling assembly (31) being fixedly arranged in the mounting holes (333).

5. The sampling and detection device for extracting liquid according to claim 4, characterized in that: The sampling assembly (31) comprises an electric push rod (311) fixedly arranged in the mounting hole (333); an output end of the electric push rod (311) is fixedly connected to a sampler (313) via a support plate (312); the sampler (313) comprises a sampling barrel fixedly arranged at the bottom of the support plate (312); and an extractor is slidably arranged on the sampling barrel.

6. The sampling and detection device for extract according to claim 5, characterized in that: The control device (50) comprises a data processor (51), and the data processor (51) is electrically connected to the sampling component (31), the lifting motor (321), the adjustment motor (423), and the driving motor (431) respectively. The operation time is set by the data processor (51), thereby controlling the movement of the above-mentioned devices.

7. A method for detecting pharmaceutical liquid, applied to the sampling and detection device for extracting liquid according to claim 6, characterized in that: Step 1: setting the sampling and detection time by the control device (50) so that the two groups of driving components (43) respectively arranged in the sliding slot (11) work simultaneously; Step 2: starting the driving component (43) and driving the transmission plate (41) slidingly disposed in the sliding groove (11), and driving the regulating component (42) disposed above the regulating component (42) and the sampling mechanism (30) located at the output end of the regulating component (42) to move to above the extraction liquid through the transmission plate (41); Step 3: The lifting component (32) drives the rotating component (33), and the sampling component (31) at the output end of the rotating component (33) is lifted and moved, so that the sampling component (31) moves into the extraction liquid for sampling. At the same time, the rotating component (33) is controlled to drive the sampling component (31) to rotate, so that sampling can be performed at different times according to time settings; Step 4: The lifting component (32), the adjusting component (42) and the driving component (43) operate in sequence to drive the sample in the sampling component (31) to move above the detection mechanism (20), and the sampling component (31) is controlled to sequentially add the sample to the infrared spectrometer (21) and the liquid chromatograph (22) for detection.

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