A plant extract antibacterial soothing wet wipes liquid and its preparation method and the wet wipes obtained

Abstract

The present application discloses a plant extract antibacterial soothing wet wipes liquid, a preparation method thereof and the wet wipes obtained, and belongs to the field of plant extract products. A plant extract antibacterial soothing wet wipes liquid, comprising the following raw materials in weight percentage: 0.1%~5% camellia alcohol extract; 0.005%~0.05% camellia essential oil; 0.05%~10.1% plant extract composition; 1.0%~3.0% skin care moisturizer; 0.03%~0.1% pH adjuster; 0.05%~0.5% biological antibacterial agent; 0~0.8% preservative; 0~0.5% antioxidant; the balance is water; the ingredients of the plant extract composition include one or more of Cnidium monnieri extract, Sophora flavescens extract, Stemona extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract. The wet wipes liquid of the present application has the effect of antibacterial, reducing skin irritation and maintaining long-term stability.

Description

Technical Field

[0001] The present application relates to the field of plant extract products, and in particular to a plant extract antibacterial soothing wet wipes liquid, a preparation method thereof, and the wet wipes obtained. Background Art

[0002] Wet wipes are non-woven fabrics with appropriate amount of wet wipes liquid added to moisten paper towels that have a cleaning effect on hands, skin, mucous membranes, surfaces of objects, etc. With the improvement of the quality of life, the role of wet wipes in people's daily lives has become increasingly important.

[0003] In addition to the cleaning function, wet wipes generally also have antibacterial effects to meet people's requirements for safety and protection. The wet wipes liquid allows wet wipes to have cleaning and antibacterial effects. However, in order to maintain the antibacterial effect, the wet wipes liquid on the market will add chemical fungicides that are irritating to the skin, which can easily cause skin allergic reactions. Long-term use will cause skin health problems. Adding plant extracts as the active ingredient for antibacterial is prone to instability of the active ingredient, especially the problem of poor antibacterial care effect on women's private parts. Summary of the invention

[0004] In order to be able to inhibit bacteria while reducing skin irritation and maintaining long-term stability, the present application provides a plant-extracted antibacterial soothing wet wipes liquid, a preparation method thereof, and the wet wipes produced.

[0005] In the first aspect, the present application provides a plant-based antibacterial soothing wet wipes liquid using the following technical solution:

[0006] A plant extract antibacterial soothing wet wipes liquid, comprising the following raw materials in percentage by weight:

[0007] Camellia ethanol extract 0.1% to 5%;

[0008] Camellia essential oil 0.005%~0.05%;

[0009] Plant extract composition 0.05% to 10.1%;

[0010] Skin care moisturizer 1.0% to 3.0%;

[0011] pH adjuster 0.03% to 0.1%;

[0012] Biological antibacterial agent 0.05%~0.5%;

[0013] Preservatives 0-0.8%;

[0014] Antioxidant 0-0.5%;

[0015] The balance is water;

[0016] The plant extract composition comprises one or more of Cnidium monnieri extract, Sophora flavescens extract, Stemona tuberosa extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract.

[0017] By adopting the above technical solution, camellia has good antioxidant and anti-inflammatory properties, can reduce oxidative stress, relieve skin discomfort, and is non-irritating.

[0018] Camellia has a variety of active ingredients, and there are also differences in properties between the active ingredients. Therefore, camellia alcohol extract and camellia essential oil are added to the wet wipes liquid respectively. Camellia alcohol extract is rich in saponins, flavonoids and polyphenol compounds, which can act on the skin and provide good soothing and antibacterial effects. Camellia essential oil is rich in natural oils and brings fragrance. At the same time, it cooperates with camellia alcohol extract to improve the cleansing effect on the skin. It is suitable for combination with wet wipes fabrics to achieve the purpose of efficient sterilization.

[0019] In addition, the ingredients of the plant extract composition can be selected from Cnidium monnieri extract, Sophora flavescens extract, Stemona bulbus extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract, so that the wet wipes can be used on the face, trunk and limbs, and have good antibacterial and soothing effects on female private parts. Moreover, due to the addition of camellia alcohol extract and camellia essential oil, the wet wipes have more prominent sustained antibacterial properties and long-lasting soothing performance on female private parts, and the overall effect is good.

[0020] Optionally, the plant extract composition comprises the following components in percentage by weight:

[0021] Sophora flavescens extract 0.05% to 5.0%;

[0022] Stemona extract 0.05%~5.0%;

[0023] Phellodendron amurense extract 0.05% to 5.0%;

[0024] The above weight percentages are all the proportions of each component in the wet wipes liquid.

[0025] By adopting the above technical scheme and compounding the above extracts, and through the combination of antibacterial ingredients such as osthole and matrine, the wet wipes have obvious antibacterial and anti-inflammatory effects, and can improve skin redness, swelling and itching, and also have a good soothing effect on women's private parts.

[0026] Optionally, the plant extract composition comprises the following components in percentage by weight:

[0027] Sophora flavescens extract 0.05% to 5.0%;

[0028] Stemona extract 0.05%~5.0%;

[0029] Perilla extract 0.05% to 5.0%;

[0030] Hops extract 0.05% to 5.0%;

[0031] The above weight percentages are all the proportions of each component in the wet wipes liquid.

[0032] By adopting the above technical scheme, the above extracts are compounded and used, and through the combination of soothing and anti-inflammatory ingredients such as stemonine, perillyl alcohol and perilline, a soothing effect on the skin is produced, while also playing a role in moisturizing and hydrating the skin.

[0033] Optionally, the plant extract composition comprises the following components in percentage by weight:

[0034] Cnidium monnieri extract 0.05% to 5.0%;

[0035] Phellodendron amurense extract 0.05% to 5.0%;

[0036] Perilla extract 0.05% to 5.0%;

[0037] Hops extract 0.05% to 5.0%;

[0038] The above weight percentages are all the proportions of each component in the wet wipes liquid.

[0039] By adopting the above technical scheme and compounding the above extracts, and through the combination of antibacterial ingredients such as osthole, hop oil and hop ketone, the wet wipes have good antibacterial and anti-inflammatory effects on the female private parts, and the long-term effect is improved. At the same time, the effect of repairing the tissue vitality of the female private parts is significantly improved.

[0040] Optionally, the preparation method of the camellia alcohol extract is: washing petals of fresh camellia with an alcohol washing solvent, then crushing the petals to obtain petal fragments, ultrasonically extracting the petal fragments with an alcohol extraction solvent at room temperature, separating to obtain an extract, and the extract is used as the camellia alcohol extract;

[0041] Optionally, the preparation method of the camellia essential oil is: fresh camellia petals are washed with an alcohol washing solvent, and then the petals are distilled with water vapor, and the organic phase is collected as the camellia essential oil.

[0042] By adopting the above technical solution, fresh camellia is used as the raw material for extraction, effectively avoiding the destruction of the active ingredients of camellia due to drying or baking, retaining heat-sensitive ingredients such as anthocyanins and volatile oils, so that such heat-sensitive ingredients can be extracted and act on the skin, and the alcohol washing solvent is first used to rinse the petals to remove dirt, bacteria and insect eggs on the surface of the petals, and the rinsing method reduces the loss of active ingredients in the petals. For active ingredients that cannot be extracted by alcohol extraction solvents, such as some oils, alkaloids and glycosides in camellia, the essential oil part is extracted and collected by steam distillation, so that the active ingredients in the camellia are compounded and applied in wet wipes.

[0043] Optionally, the alcohol washing solvent comprises 50-90 wt % ethanol solution, and the rinsing time of the fresh camellia petals and the alcohol washing solvent is 5s-60s;

[0044] Optionally, the alcohol extraction solvent contains 70-80wt% ethanol solution and C14-C18 glycol in a weight ratio of 1:(0.08-0.14), the weight ratio of petal fragments to the alcohol extraction solvent is 1:(3.5-5), and the ultrasonic frequency during the ultrasonic extraction process is 20-25KHz, the ultrasonic power is 80-120W, and the ultrasonic time is 20-40min.

[0045] By adopting the above technical scheme, a 70-80wt% ethanol solution is used, the concentration is moderate and the extraction effect is good, and the addition of C14-C18 alkyl glycol helps to bring out active ingredients such as volatile oils, thereby improving the extraction rate. The required amount of alcohol extraction solvent is small, so the extract does not need to be concentrated to be used as a camellia alcohol extract. In addition, C14-C18 alkyl glycol helps the active ingredients penetrate into the skin, enhances the soothing effect, and improves the skin repair effect.

[0046] Controlling the frequency, power and time of the ultrasonic extraction process can not only achieve a higher extraction rate but also reduce the impact on sensitive components.

[0047] Optionally, the skin care moisturizer comprises one or more of trehalose, glycerin, hyaluronic acid, fucus vesiculosus extract, lactobacillus lysate, 1,2-hexanediol, ethylhexylglycerin, betaine, biosaccharide gum, glyceryl glucoside, ceramide and amino acid conditioner.

[0048] By adopting the above technical scheme, the above ingredients have good hydrating and moisturizing functions, lock in skin moisture, and at the same time promote camellia alcohol extract, camellia essential oil and plant extract composition to penetrate the skin surface, exert antibacterial and anti-inflammatory effects, enhance the soothing effect, and are gentle and non-irritating to women's private parts, thereby improving the use experience.

[0049] Optionally, the skin care moisturizer comprises trehalose, glycerin, Fucus vesiculosus extract and betaine.

[0050] Optionally, the skin care moisturizer comprises glycerin, hyaluronic acid and glyceryl glucoside.

[0051] Optionally, the skin care moisturizer comprises 1,2-hexanediol, ethylhexylglycerin and betaine.

[0052] Optionally, the biological antibacterial agent is a yeast fermentation product extract.

[0053] By adopting the above technical solution, the yeast fermentation product extract can quickly kill various bacteria and fungi through the synergistic effect of multiple components, which is safe, gentle and non-irritating.

[0054] Optionally, the pH adjuster comprises one or both of citric acid and sodium citrate.

[0055] By adopting the above technical scheme, citric acid and sodium citrate have a good pH regulating effect, so that the wet wipes liquid maintains a suitable pH environment and exerts the efficacy of camellia alcohol extract, camellia essential oil and plant extract composition.

[0056] Optionally, the preservative comprises one or more of lauryl pyridinium chloride, chlorphenesin, phenoxyethanol, cymene-5-ol, sodium benzoate, potassium sorbate, and dichlorobenzyl alcohol;

[0057] Optionally, the antioxidant is p-hydroxyacetophenone.

[0058] By adopting the above technical solution, the preservatives and antioxidants composed of the above ingredients can extend the storage and use period of the wet wipes liquid and provide good antibacterial effect.

[0059] In the second aspect, the present application provides a method for preparing a plant-based antibacterial soothing wet wipes liquid, which adopts the following technical scheme: a method for preparing a plant-based antibacterial soothing wet wipes liquid, comprising the following steps:

[0060] Take part of the water, add camellia alcohol extract, camellia essential oil, plant extract composition, skin care moisturizer, biological antibacterial agent, preservative and antioxidant, add the remaining water and stir evenly, then add the pH adjuster, adjust the pH, and stir evenly to obtain wet wipes liquid.

[0061] In a third aspect, the present application provides a method for preparing wet wipes using the following technical solution:

[0062] A wet wipe comprising a cloth and a plant-extracted antibacterial soothing wet wipe liquid.

[0063] By adopting the above technical solution, the wet wipes liquid has antibacterial and soothing effects. Combined with the wiping action of the soft and skin-friendly wet wipes fabric, it can quickly and efficiently achieve the sterilization effect. At the same time, the wet wipes liquid is evenly dispersed on the skin surface, and the soothing effect is also improved.

[0064] Optionally, the weight ratio of the fabric to the plant-based antibacterial soothing wipes liquid is 1:(2-4)

[0065] In summary, this application has the following beneficial effects:

[0066] 1. The present application adds camellia alcohol extract and camellia essential oil to the wet wipes liquid respectively. Camellia alcohol extract is rich in saponins, flavonoids and polyphenol compounds, which can act on the skin and provide good soothing and antibacterial effects. Camellia essential oil is rich in natural oils and brings fragrance. At the same time, it cooperates with camellia alcohol extract to improve the cleansing effect on the skin. It is suitable for combination with wet wipes cloth to achieve the purpose of efficient sterilization.

[0067] 2. The wet wipes liquid is also formulated with the ingredients of the plant extract composition, which can be selected from Cnidium monnieri extract, Sophora flavescens extract, Stemona bulbus extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract, so that the wet wipes liquid can be used not only on the face, trunk and limbs, but also has good antibacterial and soothing effects on female private parts. In addition, due to the addition of camellia alcohol extract and camellia essential oil, the wet wipes liquid has more outstanding sustained antibacterial performance and long-lasting soothing performance on female private parts, and the overall effect is good.

[0068] 3. The liquid in the wet wipes is weakly acidic, which maintains a good weakly acidic environment in the private parts when used; no chemical disinfectant ingredients are added, and it is gentle and non-irritating.

[0069] It combines antibacterial, soothing and nourishing effects in one, gentle and safe. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] Figure 1 This is a record of the results of testing the soothing effect using the zebrafish larvae neutrophil inhibition rate method in Example 1 of the present application. DETAILED DESCRIPTION

[0071] The present application is described in further detail below.

[0072] The wet wipes of the present application can not only be used for disinfection and cleaning in daily life, but also can be used for hygienic cleaning of female private parts. Cleaning wet wipes for female private parts are relatively rare at present, mainly because female private parts are relatively sensitive and easily irritated. When wet wipes are used to wipe private parts, private parts will be exposed to a large amount of wet wipes liquid in a short time, so the composition of wet wipes liquid is demanding, and the composition of ordinary sanitary wet wipes liquid is easy to irritate vaginal skin and cause discomfort, and the flora species of female private parts are special, and the antibacterial effect of ordinary wet wipes liquid on these types of flora is not good, and the flora species of female private parts are numerous, and ordinary sanitary wet wipes liquid is easy to affect the flora balance of vagina, resulting in a significant reduction in the long-term effect of soothing and antibacterial. Therefore, it is necessary to apply wet wipes to female private parts in terms of efficacy.

[0073] Cnidium monnieri extract, Sophora flavescens extract, Stemona japonica extract, Phellodendron amurense extract, Perilla frutescens extract, Hops extract and Fucus vesiculosus extract are all commercially available water-soluble extracts.

[0074] Yeast fermentation product extract was purchased from Baikuirui Biotechnology Co., Ltd.

[0075] Preparation Example 1

[0076] The preparation method of camellia ethanol extract comprises the following steps:

[0077] Fresh camellia petals were taken and washed with an alcohol washing solvent, wherein the alcohol washing solvent was a 50 wt % ethanol solution. The washing process was that the alcohol washing solvent continuously washed the fresh camellia petals for 60 seconds.

[0078] The washed petals are broken into pieces, and the petal pieces are immersed in an alcohol extraction solvent at room temperature, wherein the alcohol extraction solvent is compounded by 70wt% ethanol solution and C14-C18 alkyl glycol according to a weight ratio of 1:0.08, and the weight ratio of the petal pieces to the alcohol extraction solvent is 1:3.5. Ultrasonic extraction is then performed, wherein the ultrasonic frequency is 20KHz, the ultrasonic power is 80W, the ultrasonic time is 40min, and the ultrasonic extraction is followed by filtration, and the obtained extract is used as camellia alcohol extract.

[0079] Preparation Example 2

[0080] The preparation method of camellia ethanol extract comprises the following steps:

[0081] Fresh camellia petals were taken and washed with an alcohol washing solvent, wherein the alcohol washing solvent was a 90 wt % ethanol solution. The washing process was that the alcohol washing solvent continuously washed the fresh camellia petals for 5 seconds.

[0082] The washed petals are broken into pieces, and the petal pieces are immersed in an alcohol extraction solvent at room temperature, wherein the alcohol extraction solvent is compounded by 80wt% ethanol solution and C14-C18 alkyl glycol according to a weight ratio of 1:0.14, and the weight ratio of the petal pieces to the alcohol extraction solvent is 1:5. Ultrasonic extraction is then performed, wherein the ultrasonic frequency is 25KHz, the ultrasonic power is 120W, the ultrasonic time is 20min, and the ultrasonic extraction is followed by filtration, and the obtained extract is used as camellia alcohol extract.

[0083] Preparation Example 3

[0084] The preparation method of camellia ethanol extract comprises the following steps:

[0085] Fresh camellia petals were taken and washed with an alcohol washing solvent, wherein the alcohol washing solvent was a 50 wt % ethanol solution. The washing process was that the alcohol washing solvent continuously washed the fresh camellia petals for 60 seconds.

[0086] The washed petals are broken into pieces, and the petal pieces are immersed in an alcohol extraction solvent at room temperature, wherein the alcohol extraction solvent is a 70wt% ethanol solution, and the weight ratio of the petal pieces to the alcohol extraction solvent is 1:3.5. Ultrasonic extraction is then performed, wherein the ultrasonic frequency is 20KHz, the ultrasonic power is 80W, and the ultrasonic time is 40min. After the ultrasonic extraction, the extract is filtered, and the obtained extract is used as the camellia alcohol extract.

[0087] Preparation Example 4

[0088] The preparation method of camellia ethanol extract comprises the following steps:

[0089] Fresh camellia petals were taken and washed with an alcohol washing solvent, wherein the alcohol washing solvent was a 50 wt % ethanol solution. The washing process was that the alcohol washing solvent continuously washed the fresh camellia petals for 60 seconds.

[0090] The washed petals are broken into pieces, and the petal pieces are soaked in an alcohol extraction solvent, wherein the alcohol extraction solvent is compounded by 70wt% ethanol solution and C14-C18 alkyl glycol according to a weight ratio of 1:0.08, and the weight ratio of the petal pieces to the alcohol extraction solvent is 1:15. Ultrasonic extraction is then carried out at 60°C, and the ultrasonic frequency, ultrasonic power and ultrasonic time are 20KHz, 80W and 40min during the ultrasonic extraction process. After the ultrasonic extraction, the extraction is filtered, and the obtained extract is concentrated under reduced pressure at 40°C to concentrate the volume of the extract to 30% of the original volume, so as to obtain a camellia alcohol extract.

[0091] Preparatory Example 1

[0092] The preparation method of camellia essential oil comprises the following steps:

[0093] Fresh camellia petals were taken and washed with an alcohol washing solvent, wherein the alcohol washing solvent was a 50 wt % ethanol solution. The washing process was that the alcohol washing solvent continuously washed the fresh camellia petals for 60 seconds.

[0094] The washed petals were soaked in water for 1 h, with the weight ratio of petals to water being 1:20, and then steam distilled for 4 h, and the organic phase was collected as camellia essential oil.

[0095] Example 1

[0096] The preparation method of plant-extracted antibacterial soothing wet wipes comprises the following steps:

[0097] Take 60% of the total weight of water, add camellia alcohol extract, camellia essential oil, plant extract composition, skin care moisturizer, biological antibacterial agent, preservative and antioxidant, stir well, then add pH adjuster, add the remaining water, adjust the pH to 3.5, stir well to obtain wet wipes liquid.

[0098] Among them, the camellia alcohol extract is selected from Preparation Example 1, and the camellia essential oil is selected from Preparation Example 1.

[0099] The plant extract composition consists of cnidium monnieri extract, sophora flavescens extract, stemonae extract and phellodendron amurense extract.

[0100] The skin care moisturizer is composed of trehalose, glycerin, fucus vesiculosus extract and betaine. In the skin care moisturizer, the weight ratio of trehalose, glycerin, fucus vesiculosus extract and betaine is 1:2:0.5:1.

[0101] The pH adjuster was citric acid.

[0102] The biological antibacterial agent is an extract of yeast fermentation products.

[0103] The preservative is phenoxyethanol.

[0104] The antioxidant is p-hydroxyacetophenone.

[0105] The weight percentage of each raw material in the wet wipes liquid:

[0106] Camellia ethanol extract 5%, camellia essential oil 0.05%, Cnidium monnieri extract 0.05%, Sophora flavescens extract 5%, Stemona japonica extract 0.05%, Phellodendron amurense extract 5%, skin care moisturizer 3%, pH adjuster 0.03%, bio-antibacterial agent 0.1%, preservative 0.2%, antioxidant 0.5%, and the balance is water.

[0107] Example 2

[0108] The preparation method of plant-extracted antibacterial soothing wet wipes comprises the following steps:

[0109] Take 70% of the total weight of water, add camellia alcohol extract, camellia essential oil, plant extract composition, skin care moisturizer, biological antibacterial agent and preservative, add the remaining water, stir evenly, then add pH adjuster, adjust pH to 3.5, stir evenly to obtain wet wipes liquid.

[0110] Among them, the camellia alcohol extract is selected from Preparation Example 2, and the camellia essential oil is selected from Preparation Example 1.

[0111] The plant extract composition is cnidium monnieri extract and perilla frutescens extract.

[0112] The skin care moisturizer consists of trehalose, glycerin, fucus vesiculosus extract and betaine, and the weight ratio of trehalose, glycerin, fucus vesiculosus extract and betaine is 1:2:0.5:1.

[0113] The pH adjuster was citric acid.

[0114] The biological antibacterial agent is an extract of yeast fermentation products.

[0115] The preservatives consist of phenoxyethanol and potassium sorbate, and the weight ratio of phenoxyethanol to potassium sorbate is 1:1.

[0116] The weight percentage of each raw material in the wet wipes liquid:

[0117] Camellia ethanol extract 0.1%, camellia essential oil 0.005%, cnidium monnieri extract 5%, perilla extract 5.0%, skin care moisturizer 1.0%, pH adjuster 0.03%, bio-antibacterial agent 0.05%, preservative 0.8%, and the balance is water.

[0118] Example 3

[0119] The preparation method of plant-extracted antibacterial soothing wet wipes comprises the following steps:

[0120] Take 60% of the total weight of water, add camellia alcohol extract, camellia essential oil, plant extract composition, biological antibacterial agent, antioxidant and skin care moisturizer, add the remaining water, stir evenly, then add pH adjuster, adjust pH to 3.5, stir evenly to obtain wet wipes liquid.

[0121] Among them, the camellia alcohol extract is selected from Preparation Example 1, and the camellia essential oil is selected from Preparation Example 1.

[0122] The plant extract composition consists of sophora flavescens extract, stemona radix extract and phellodendron amurense extract.

[0123] The skin care moisturizer consists of 1.2-hexanediol, glycerin, fucus vesiculosus extract and betaine. In the skin care moisturizer, the weight ratio of 1.2-hexanediol, glycerin, fucus vesiculosus extract and betaine is 1:2:0.5:1.

[0124] The biological antibacterial agent is an extract of yeast fermentation products.

[0125] The antioxidant is p-hydroxyacetophenone.

[0126] The pH adjuster was citric acid.

[0127] The weight percentage of each raw material in the wet wipes liquid:

[0128] Camellia ethanol extract 2%, camellia essential oil 0.005%, Sophora flavescens extract 0.05%, Stemona japonica extract 5%, Phellodendron amurense extract 0.05%, skin care moisturizer 2.25%, bio-antibacterial agent 0.5%, antioxidant 0.5%, pH adjuster 0.03%, and the balance is water.

[0129] Example 4

[0130] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0131] The difference between this embodiment and embodiment 1 is that the camellia ethanol extract is selected from preparation example 3.

[0132] Example 5

[0133] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0134] The difference between this embodiment and embodiment 1 is that the camellia ethanol extract is selected from preparation example 4.

[0135] Example 6

[0136] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0137] The difference between this embodiment and embodiment 1 is that the plant extract composition consists of perilla extract and hop extract.

[0138] The weight percentages of the above extracts in the wet wipes liquid are as follows: 0.05% perilla extract and 5% hop extract.

[0139] Example 7

[0140] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0141] The difference between this embodiment and embodiment 1 is that the plant extract composition consists of Sophora flavescens extract, Stemona japonica extract, Perilla frutescens extract and Hops extract.

[0142] Among them, the weight percentages of the above extracts in the wet wipes liquid are: 0.05% of Sophora flavescens extract, 5% of Stemona japonica extract, 0.05% of Perilla frutescens extract, and 5% of Hops extract.

[0143] Example 8

[0144] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0145] The difference between this embodiment and embodiment 1 is that the plant extract composition consists of Sophora flavescens extract, Stemona japonica extract, Perilla frutescens extract and Hops extract.

[0146] Among them, the weight percentages of the above extracts in the wet wipes liquid are: 5% of Sophora flavescens extract, 0.05% of Stemona japonica extract, 5% of Perilla frutescens extract, and 0.05% of Hops extract.

[0147] Example 9

[0148] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0149] The difference between this embodiment and embodiment 1 is that the plant extract composition consists of Cnidium monnieri extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract.

[0150] Among them, the weight percentages of the above extracts in the wet wipes liquid are: 5% of Cnidium monnieri extract, 0.05% of Phellodendron amurense extract, 0.05% of Perilla frutescens extract, and 5% of Hops extract.

[0151] Example 10

[0152] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0153] The difference between this embodiment and embodiment 1 is that the plant extract composition consists of Cnidium monnieri extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract.

[0154] Among them, the weight percentages of the above extracts in the wet wipes liquid are: 0.05% of Cnidium monnieri extract, 5% of Phellodendron amurense extract, 5% of Perilla frutescens extract, and 0.05% of Hops extract.

[0155] Embodiment 11

[0156] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0157] The difference between this embodiment and embodiment 1 is that the skin care moisturizer consists of glycerin, hyaluronic acid and glyceryl glucoside, and the weight ratio of glycerin, hyaluronic acid and glyceryl glucoside is 1:0.02:0.5.

[0158] Example 12

[0159] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0160] The difference between this embodiment and embodiment 1 is that the skin care moisturizer consists of 1,2-hexanediol, ethylhexylglycerin and betaine, and the weight ratio of 1,2-hexanediol, ethylhexylglycerin and betaine is 1:0.1:1.

[0161] Comparative Example 1

[0162] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0163] The difference between this comparative example and Example 1 is that the camellia essential oil is used twice as much as the camellia alcohol extract in the plant-based antibacterial soothing wet wipes, that is, the camellia alcohol extract is not added, and the weight percentage of the added camellia essential oil is 0.01%.

[0164] Comparative Example 2

[0165] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0166] The difference between this comparative example and Example 1 is that an equal amount of camellia seed oil is used to replace camellia essential oil in the plant-based antibacterial soothing wet wipes, that is, no camellia essential oil is added, and the weight percentage of the added camellia seed oil is 0.005%. The camellia seed oil is prepared by cold pressing camellia seeds after shelling.

[0167] Comparative Example 3

[0168] Preparation method of plant-extracted antibacterial soothing wet wipes:

[0169] The difference between this comparative example and Example 1 is that an equal amount of camellia alcohol extract plant extract composition is used in the plant extract antibacterial soothing wet wipes, that is, no plant extract composition is added, and the weight percentage of camellia alcohol extract added is 10.1%.

[0170] Application examples and comparative application examples

[0171] The plant-based antibacterial soothing wet wipes liquid is used to wet the fabric to obtain wet wipes. The weight ratio of the fabric to the plant-based antibacterial soothing wet wipes liquid is 1:4. The fabric can be viscose polyester composite spunlace fabric, pure cotton spunlace fabric, wood pulp spunlace fabric, or plant fiber spunlace fabric. This application example and the comparative application example specifically use plant fiber spunlace fabric.

[0172] The sources of the plant-based antibacterial soothing wipes in the application examples and comparative application examples are shown in Table 1.

[0173] Table 1

[0174]

[0175]

[0176] Comparative Application Example 4

[0177] This comparative application example is a commercially available plant-based wet wipe with antibacterial effect.

[0178] Effect detection antibacterial test: refer to GB 15979-2002, and the antibacterial performance of the wet wipes prepared by the corresponding use case and comparative application example is tested. Take 5 ml of the wet wipe sample extrusion liquid and the control sample liquid respectively in a test tube, add 100 μL of the prepared bacterial suspension to each and mix evenly to start timing. After 2 minutes of action, take 0.5 ml and put it into a test tube containing 5 ml of PBS solution, mix it thoroughly, make appropriate dilutions, and then take 2 to 3 dilutions, take 0.5 ml respectively, put it in two plates, and use the culture medium cooled to 40 to 45 ° C to count the average colony number of the sample B and the average colony number of the control sample A. Antibacterial rate % calculation formula: Antibacterial rate % = (AB) / A * 100%. According to the above method, the antibacterial rate of the samples against Escherichia coli, Staphylococcus aureus, Candida albicans, and Gardnerella was tested respectively. Another group of samples were placed in a constant temperature and humidity environment of 37±1℃, 70%RH for 12 weeks, and then the inhibition rate of the samples against Escherichia coli, Staphylococcus aureus, Candida albicans and Gardnerella was tested. The inhibition rate after 2 minutes of exposure to the bacterial solution was recorded and recorded as the continuous inhibition rate.

[0179] Wiping sterilization test: The following test method is used to perform a wiping sterilization test on the wet wipes prepared in the corresponding use case and the comparative application case. The plastic sheet carrier is soaked in 75% alcohol for 30 minutes before use and then dried for use; a bacterial suspension of 1 to 5*10 is prepared according to the conventional laboratory method. 9 cfu / ml, the bacterial species is Gardnerella, and the live bacterial plate count is performed on the bacterial suspension during the test; 0.2ml of bacterial liquid is taken respectively, and naturally dripped onto 6 carriers, and placed at room temperature for 30min; one of the carriers is taken, and the amount of bacteria on the carrier is recovered by elution counting, and the count is A; colony recovery method: put the carrier into 20ml sterile physiological saline, after sufficient elution, take 1ml of eluate for gradient dilution, select the appropriate dilution for plate counting, do 2 parallels, and multiply the result after culture counting by the dilution multiple and then multiply by 20 to obtain the amount of bacteria recovered on the carrier A. Take the other 5 carriers and wipe them with the sample to be tested. Wiping method: 5 carriers are wiped 1 time, 2 times, 3 times, 4 times and 5 times in the same direction respectively, and a new wet wipe is used for each wipe, and the wet wipe is folded in half once when wiping. Wiping force: simulate the wiping force of actual wet wipes; take the carrier after wiping and recover the number of colonies on the carrier through the colony recovery method, and the count is C; calculate the wiping sterilization rate, and keep 1 decimal place in the result, wiping sterilization rate % = (1-C / A) * 100%, and record the number of wiping times required for the wiping sterilization rate to be greater than 99%.

[0180] The above test results are shown in Table 2.

[0181] Table 2

[0182]

[0183]

[0184] From the test results in Table 2, it can be seen that the plant-based antibacterial soothing wipes can have an equally strong antibacterial effect on pathogenic bacteria and fungi, while the ordinary plant-based antibacterial wipes on the market have relatively weak antibacterial ability, and the antibacterial effect on Candida albicans fungi is significantly reduced. Candida albicans and Gardnerella are common pathogens that cause gynecological vaginal diseases. The results show that the plant-based antibacterial soothing wipes can play an antibacterial role in cleaning the female private parts.

[0185] From the results of the sustained antibacterial rate, it can be seen that the plant-based antibacterial soothing wipes have good stability, and long-term placement has little effect on its antibacterial ability. Among them, from the comparison between Application Example 1 and Comparative Application Examples 1-3, it can be seen that the combination of camellia alcohol extract, camellia essential oil and plant extract composition has a significant effect on the sustainability of the antibacterial effect; further comparing Application Example 1 with Application Examples 9-10, when the plant extract composition is compounded with Cnidium monnieri extract, Phellodendron chinense extract, Perilla frutescens extract and Hops extract, the sustained antibacterial effect on Gardnerella is further improved.

[0186] Judging from the results of the wiping sterilization test, wet wipes containing plant-based antibacterial soothing wipes can achieve a 99% sterilization rate for Gardnerella with fewer wipes. Camellia essential oil combined with camellia alcohol extract improves the cleansing effect on the skin and is suitable for combination with wet wipes fabrics to achieve the purpose of efficient sterilization.

[0187] Vaginal mucosa test: Referring to GB 15979-2002, the wet wipes prepared in the examples and comparative examples were subjected to multiple vaginal mucosal irritation tests to obtain irritation indexes, wherein an irritation index less than 1 represents no irritation intensity. Another wet wipes liquid of the comparative application example was tested.

[0188] Soothing effect test: Referring to the zebrafish neutrophil inhibition rate test, the wet wipes prepared in the embodiments and comparative examples were subjected to vaginal mucosal irritation tests. The inhibition rate of the sample group was calculated based on the number of neutrophils in the control group, model group, positive drug group and sample group. The inhibition rate of the positive drug group was 63.29%. The higher the inhibition rate, the better the soothing effect.

[0189] Tissue vitality test: 3D skin model stimulated by sodium dodecyl sulfate ( -Epi), wherein artificial simulated synthetic vaginal fluid (BZ181) is added to the culture medium of the 3D skin model to simulate the vaginal epidermis, and the wet wipes prepared in the embodiment and the comparative example are used as samples according to the following MTT tissue viability test.

[0190] The above test results are shown in Table 3.

[0191] Table 3

[0192]

[0193] From the test results of the vaginal mucosa test, it can be seen that compared with the wet wipes liquid of ordinary wet wipes, the plant-based antibacterial soothing wet wipes liquid has no irritation to the vaginal mucosa and is gentle and comfortable.

[0194] From the test results of the soothing efficacy test, it can be seen that the plant-based antibacterial soothing wipes have a high inhibition rate on skin inflammation and good soothing ability. At the same time, combined with Application Example 1 and Comparative Application Examples 1-3, it can be seen that the combination of camellia alcohol extract, camellia essential oil and plant extract composition has an effect on soothing ability. Further combined with Application Example 1 and Application Examples 4-5, it can be seen that the use of camellia alcohol extract at room temperature and a specific alcohol extraction solvent will also have an effect on soothing ability.

[0195] From the test results of tissue vitality test, it can be seen that plant-based antibacterial soothing wipes have an enhancing effect on the tissue vitality of genital skin. Improved tissue vitality means high skin repair ability and further improved comfort. At the same time, combined with Application Example 1 and Comparative Application Examples 1-3, it can be seen that the combination of camellia alcohol extract, camellia essential oil and plant extract composition has an effect on tissue vitality. Further combined with Application Example 1 and Application Examples 9-10, it can be seen that when the plant extract composition is compounded with Cnidium monnieri extract, Phellodendron chinense extract, Perilla frutescens extract and Hops extract, the improvement of tissue vitality is more obvious and the repair ability is further improved.

[0196] Wet wipes usage test: 64 female volunteers were recruited, all of whom had symptoms of redness, swelling and itching in their vulva. The volunteers were randomly divided into 16 groups, and used the wet wipes prepared in the application example and the comparative application example to wipe and clean the vulva for 5 consecutive days, once in the morning and once in the evening. On the 6th day, the volunteers scored the redness, swelling and itching of the vulva based on their feelings. The scoring range was 0-5 points. The higher the score, the better the efficacy. The score of each group of volunteers was averaged. In addition, starting from the 6th day, wet wipes were not used to clean the vulva for 7 consecutive days. On the 13th day, the volunteers scored the redness, swelling and itching of the vulva again.

[0197] The above test results are shown in Table 4.

[0198] Table 4

[0199]

[0200] It can be seen that in the short term, ordinary wet wipes can remove germs and excess secretions and improve the symptoms of redness, swelling and itching. However, the discomfort of redness, swelling and itching reappeared on the 8th day after cleaning stopped. The plant-based antibacterial soothing wet wipes have good sustained antibacterial ability, which can inhibit the reproduction of vulvar bacteria for a long time, thereby promoting the long-term soothing and repairing effects. After stopping using wet wipes to clean the vulva, you can still maintain a good feeling.

[0201] This specific implementation manner is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the specific implementation manner as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A plant extract antibacterial soothing wet wipes liquid, characterized by: Contains the following raw materials in weight percentage: Camellia ethanol extract 0.1%~5%; Camellia essential oil 0.005%~0.05%; Plant extract composition 0.05% to 10.1%; Skin care moisturizer 1.0%~3.0%; pH adjuster 0.03%~0.1%; Biological antibacterial agent 0.05%~0.5%; Preservatives 0~0.8%; Antioxidant 0-0.5%; The balance is water; The biological antibacterial agent is an extract of yeast fermentation product; The plant extract composition comprises one or more of Cnidium monnieri extract, Sophora flavescens extract, Stemona tuberosa extract, Phellodendron amurense extract, Perilla frutescens extract and Hops extract; The preparation method of the camellia alcohol extract comprises: washing petals of fresh camellia with an alcohol washing solvent, then crushing the petals to obtain petal fragments, ultrasonically extracting the petal fragments with an alcohol extraction solvent at room temperature, separating to obtain an extract, and using the extract as the camellia alcohol extract; The preparation method of the camellia essential oil is as follows: fresh camellia petals are washed with an alcohol washing solvent, the petals are then distilled with steam, and an organic phase is collected as the camellia essential oil; The alcohol washing solvent comprises 50-90 wt % ethanol solution, and the rinsing time of the petals of the fresh camellia and the alcohol washing solvent is 5 s to 60 s; The alcohol extraction solvent comprises 70-80wt% ethanol solution and C14-C18 glycol in a weight ratio of 1:(0.08-0.14), the weight ratio of petal fragments to the alcohol extraction solvent is 1:(3.5-5), and during the ultrasonic extraction process, the ultrasonic frequency is 20-25KHz, the ultrasonic power is 80-120W, and the ultrasonic time is 20-40min.

2. The plant-extracted antibacterial soothing wet wipes according to claim 1, characterized in that: The plant extract composition comprises the following components in percentage by weight: Sophora flavescens extract 0.05%~5.0%; Stemona extract 0.05%~5.0%; Phellodendron amurense extract 0.05%~5.0%; Or, the plant extract composition comprises the following components in percentage by weight: Sophora flavescens extract 0.05%~5.0%; Stemona extract 0.05%~5.0%; Perilla extract 0.05%~5.0%; Hops extract 0.05%~5.0%; Or, the plant extract composition comprises the following components in percentage by weight: Cnidium monnieri extract 0.05%~5.0%; Phellodendron amurense extract 0.05%~5.0%; Perilla extract 0.05%~5.0%; Hops extract 0.05%~5.0%; The above weight percentages are all the proportions of each component in the wet wipes liquid.

3. The plant-extracted antibacterial soothing wet wipes according to claim 1, characterized in that: The skin care moisturizer comprises one or more of trehalose, glycerin, hyaluronic acid, fucus vesiculosus extract, lactobacillus lysate, 1,2-hexanediol, ethylhexylglycerin, betaine, biosaccharide gum, glyceryl glucoside, ceramide and amino acid conditioning agent.

4. A plant-extracted antibacterial soothing wet wipes liquid according to any one of claims 1 to 3, characterized in that: The pH adjuster comprises one or both of citric acid and sodium citrate.

5. A plant-extracted antibacterial soothing wet wipes liquid according to any one of claims 1 to 3, characterized in that: The preservative comprises one or more of lauryl pyridinium chloride, chlorphenesin, phenoxyethanol, cymene-5-ol, sodium benzoate, potassium sorbate, and dichlorobenzyl alcohol; The antioxidant is p-hydroxyacetophenone.

6. A method for preparing the plant-extracted antibacterial soothing wet wipes liquid according to any one of claims 1 to 5, characterized in that: The following steps are involved: Take part of the water, add camellia alcohol extract, camellia essential oil, plant extract composition, skin care moisturizer, biological antibacterial agent, preservative and antioxidant, stir well, then add pH adjuster, add remaining water after adjusting pH, stir well to obtain wet wipes liquid.

7. A wet wipe, characterized in that: The invention comprises a cloth and the plant-extracted antibacterial soothing wet wipes liquid as described in any one of claims 1 to 5.

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